CN108310212A - A kind of drug and its preparation method and application for anti-aging - Google Patents
A kind of drug and its preparation method and application for anti-aging Download PDFInfo
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Abstract
The drug and its preparation method and application that the invention discloses a kind of for anti-aging, the drug, including following components by weight:100 150 parts of 100 200 parts of Radix Codonopsis, 100 150 parts of Radix Astragali, 100 150 parts of dogwood fruit, 100 150 parts of radix rehmanniae preparata, 100 150 parts of matrimony vine, 100 150 parts of mulberries, 100 150 parts of raspberry, 100 150 parts of the fleece-flower root and radix polygonati officinalis;Further, further include 100 120 parts of 80 120 parts of red ginseng, 100 150 parts of Semen Cuscutae, 100 150 parts of sealwort, 100 150 parts of RHIIZOMA DIOSCOREAE from Henan of China, 100 150 parts of fructus schisandrae, 100 150 parts of spina date seed and ganoderma lucidum;Further, further include 100 150 parts of 100 150 parts of Radix Angelicae Sinensis, 100 150 parts of Radix Paeoniae Alba, 100 150 parts of the root bark of tree peony, 100 150 parts of rhizoma alismatis, 100 150 parts of Poria cocos and honey-fried licorice root.The present invention has the equilibrium between yin and yang for maintaining human body, the three dirty people having the same aspiration and interest of lung spleen kidney, improve the effect that sub-health state improves the anti-senility anti-fatigue of function of human body, there is the remarkable result for improving asthenic symptoms, can be acted on from reaching health care in the whole aspect of the stabilization of the metabolism of whole body and interior environment.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of drug and preparation method thereof for anti-aging and answer
With.
Background technology
The aging fatigue of human body is a natural process, but slows down aging to improve the quality of living and have become one now
Real to need, the appearance of senile symptom is mostly the internal organs underactivity since yin-Yang is unbalance, and vigour is weak or excessive loss makes
At series reaction.Then people is healthy for human body yin-yang balancing, has god;Yin and yang imbalance people will illness, early ageing, or even it is dead.Especially
It is prematurely senile crowd, nothing more than 2 points, first, native endowment is insufficient, second is that lacking of proper care after one's birth.According to the World Health Organization one
Item is global, and the survey showed that, and the people of whole world true health only accounts for 5%, and illness also only accounts for 20%, and at 75% people
Accelerate in sub-health state, that is, aging.
Invention content
The drug and its preparation method and application that the object of the present invention is to provide a kind of for anti-aging, which can
From reaching health care effect in the whole aspect of the stabilization of the metabolism of whole body and interior environment, fundamentally conditioning and enhancing immunity of organism
The characteristic pharmacological property of power is mild, and pharmacological property is mild, easy to use, and curative effect is stablized.
In order to solve the above technical problems, the technical solution adopted in the present invention is:A kind of drug for anti-aging, packet
Include following components by weight:100-200 parts of Radix Codonopsis, 100-150 parts of Radix Astragali, 100-150 parts of dogwood fruit, radix rehmanniae preparata 100-
150 parts, 100-150 parts of matrimony vine, 100-150 parts of mulberries, 100-150 parts of raspberry, 100-150 parts of the fleece-flower root and radix polygonati officinalis 100-
150 parts.
Further, further include following components by weight:80-120 parts of red ginseng, 100-150 parts of Semen Cuscutae, sealwort
100-120 parts of 100-150 parts, 100-150 parts of RHIIZOMA DIOSCOREAE from Henan of China, 100-150 parts of fructus schisandrae, 100-150 parts of spina date seed and ganoderma lucidum.
Further, further include following components by weight:100-150 parts of Radix Angelicae Sinensis, 100-150 parts of Radix Paeoniae Alba, pellet
100-150 parts of 100-150 parts of skin, 100-150 parts of rhizoma alismatis, 100-150 parts of Poria cocos and honey-fried licorice root.
Preferably, the fleece-flower root is the fleece-flower root after processing.
Preferably, the Chinese yam is RHIIZOMA DIOSCOREAE from Henan of China, and Schisandra chinensis specifically uses fructus schisandrae.
Preferably, the Radix Glycyrrhizae is honey-fried licorice root.
Further, which is made liquid, particle, plaster or pharmaceutically acceptable after extracting working substance to raw material components
Other dosage forms.
The invention further relates to the methods for preparing the drug, include the following steps:
1) bulk pharmaceutical chemicals are respectively washed, dried and smashed spare;
2) each bulk pharmaceutical chemicals powder is sieved, carries out mixing of weighing according to the ratio, obtains mixed powder;
3) mixed powder is placed in machine for decocting Chinese traditional herb medicines, using distillation, is stewed in clear soup, decocted three kinds of methods and carry out extraction conjunction successively
And juice is taken to stay slag, the dregs of a decoction are decocted again, are boiled for the first time half an hour, filters, adds water to cook 20 minutes for the second time, third
It is secondary to add water to cook 20 minutes, merge juice, is filtered with liquid pass filter spare;
4) filtrate that step 3) obtains is purified, and stands 2h, and filter again;
5) filtrate that step 3) obtains is concentrated, and cocnentration factor is 1.041-1.125, and water accounts in the liquid medicine after concentration
50%~51.1wt%, medicament account for 48.9~50wt%, then simple syrup mixing is added with the ratio of sugared content 68%, is concentrated
Afterwards to obtain the final product, it is used for the drug of anti-aging.
Medicine of the drug in anti-aging made from method the invention further relates to the drug or using claim 8
Application in object or treatment senile disease drug.
Further, the senile disease is Spleen-Qi Deficiency, insufficiency of the spleen-yang, kidney-yang deficiency, the insufficiency of both the spleen and the kindey, kidney-yin deficiency, liver kidney yin
Void, the insufficiency of heart and spleen, insufficiency of lung-QI,deficiency of lung-QI, lung-kidney deficiency is hypofunction of both the spleen and the lung, and the tired body of god is weary caused by kidney essence deficiency, has a dizzy spell, waist and knee acid
It is soft, aversion to cold and cold limbs, night pollakiuria or the heeltap not to the utmost, failure of memory, insomnia and dreamful sleep, alopecia or poliosis, easy catching a cold, micro- cough
Shortness of breath, anorexia, the aging phenomenon of sexual hypoesthesia.
The recipe principle of drug of the present invention and suit the medicine to the illness as shown in table 1.
Table 1
Prescription feature and pharmacology analysis are as follows:
The present invention is associated with using a large amount of enriching yin strengthening the essence drug with the drug that replenishes qi to invigorate the spleen, it is intended to based on kidney tonifying lean temper,
Tonifying both YIN and YANG, the three dirty people having the same aspiration and interest of spleen kidney lung.The mechanism of aging fatigue be yin and yang imbalance, the three dirty imbalance of spleen and lung kidney, and generate asthenic symptoms,
So the thinking of the present invention is:Using qi-restoratives as core, tonifying kidney and benefiting sperm, it is sun to change cloudy, is replenished qi to invigorate the spleen, enriching yin is astringed the lung, and is mended with kidney tonifying
Based on spleen, assistant educates sun in the moon, the medicine of appropriate inducing diuresis with bland drug, is mended without stagnant in addition with yang-tonifying drug.
《The Yellow Emperor's Canon of Internal Medicine》Cope with the record of asthenic symptoms:" treatment of deficiency-syndrome by reinforcement ", " damage person's benefit ", " diseases caused by over-strain should be treated by warming ", " shape deficiency person,
Warming with drugs of thick nature;Insufficiency of essence person, tonifying with drugs of thick flavor ";《The empty member mirror of reason》Described in:" controlling void has three, and lung, spleen, kidney are lungs five
Dirty day, spleen are the mother of bones of the body collectively, and kidney is the root of life, control lung and control kidney and control spleen, the roads Zhi Xuzhi are finished.”
We cure mainly asthenic symptoms, and three dirty vital essence of spleen kidney lung is insufficient, yin and yang imbalance, internal organs underactivity, and vigour is weak, or excessively
The senile symptom for being lost and arriving.The insufficiency of the kidney yang, raw in cold sensation of the genitalia, yang-energy decline, Lock-in aversion to cold and cold limbs, kidney qi disturbance in qi transformation,
Lead to bladder mistake department, the heeltap not to the utmost, nightfall yin excess Yang Zang, so night pollakiuria.The insufficiency of both the spleen and the kindey, lucid yang failing to raise, temper must be empty, god
Tired body is weary, has a dizzy spell, anorexia, involves the mind, the insufficiency of heart and spleen, insomnia and dreamful sleep, failure of memory;Spleen soil is insufficient, can not
Biochemical lung gold, hypofunction of both the spleen and the lung, lung qi does not fill, the unsaturated vapor that lung is defended, easy catching a cold, under to involve kidney metal generating water unfavorable, must lung-kidney deficiency,
Micro- cough shortness of breath.Involve kidney yin, kidney yin is deficient, and water files to nourish wood, the deficiency of liver-yin and kidney-yin, therefore soreness and weakness of waist and knees, night pollakiuria, and alopecia or beard and hair are early
In vain, failure of memory, kidney qi negative and positive are deficient must to involve that the congenital essence is deficient, cause the appearance of the early ageing symptom such as sexual hypoesthesia.Spleen
Kidney lung three dirty vital essence deficiency, yin and yang imbalance, internal organs underactivity, vigour weakness or excessive loss are the interpretation of the cause, onset and process of an illness places of assertive evidence, this
Side control using qi-restoratives as core, tonifying kidney and benefiting sperm is changed cloudy for sun, replenishes qi to invigorate the spleen, enriching yin is astringed the lung, honor《Interior warp》、《The empty member mirror of reason》It
The main points for controlling void, based on kidney tonifying lean temper, kidney tonifying both YIN and YANG, the three dirty people having the same aspiration and interest of spleen kidney lung is qi-blood tonifying.
Radix Codonopsis, Radix Astragali, radix rehmanniae preparata, dogwood fruit, matrimony vine, raspberry, the fleece-flower root, mulberries, radix polygonati officinalis in side:Tonifying spleen soil is with QI invigorating liter
Sun, strengthening spleen and tonifying lung, nourishes blood and promotes the production of body fluid, kidney tonifying water is with replenishing the vital essence and the blood, astringent method vital essence, kidney-nourishing nourishing the liver, UFA eyesight, then is given birth to earthing up
Gold, mutual generation between metal and water therapy, invigorating the lung and benefiting vital QI, fluid dryness, it is for monarch drug in a prescription to facilitate the work(of lung spleen kidney three's biochemistry jointly.
Red ginseng, Semen Cuscutae, sealwort, Chinese yam, Schisandra chinensis, spina date seed, ganoderma lucidum in side:Kind yang-tonifying person, must treating YANG within YIN, obtain positive
Person's the moon helps it, and to help the machine of biochemistry, principal drug assistance reinforces the spleen to benefit the lung nourishing liver kidney, and Semen Cuscutae aid yang qi, and red ginseng, which reinforces vital energy, can help monarch
Medicine is biochemical, and energy tranquilizing the mind, cooperation sealwort, Chinese yam, Schisandra chinensis, spina date seed, ganoderma lucidum kidney calming, restrains astringent method, QI invigorating life
The puckery essence in Tianjin thinks ministerial drug.
Radix Angelicae Sinensis, Radix Paeoniae Alba in side, replenishing and activating blood, nourishing blood and liver, with Radix Codonopsis, Radix Astragali, radix rehmanniae preparata, mulberries, sealwort, promoting the production of body fluid blood,
Blood being the material foundation of QI, qi being the governor of blood, qi-blood-body fluid biochemistry are infinite.It helps the monarch and his subjects to be harmonious, equilibrium between yin and yang, the vim and vigour of metaplasia is adjusted to carry row spleen
The vital essence of kidney lung biochemistry, it is turbid that the root bark of tree peony, Poria cocos, rhizoma alismatis, three medicines share excreting dampness, clearind deficient heat, puts down its and wins partially, and dampness removing lets out turbid, and anti-benefit
The moon taste is greasy, and the temperature of the puckery smart medicine of yang-tonifying processed is puckery, and the light spleen that oozes is wet, helps the strong fortune of drugs strengthening spleen;Honey-fried licorice root coordinating the drug actions of a prescription.Common is we's
Adjutant.
Radix Codonopsis:It is sweet in flavor, mild-natured, returns spleen, lung channel.Function:Tonifying middle-Jiao and Qi is quenched the thirst, strengthening spleen and tonifying lung, and nourishes blood and promotes the production of body fluid, the modern times grind
Study carefully and shows:Radix Codonopsis has anti-containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, saponin and Alkaloid
Cancer, decompression, expansion blood vessel, improve microcirculation, anti anoxia, enhancing hematopoiesis function, anti-aging, endurance, antiulcer, enhancing people
Body immunity, Gastrointestinal motility adjustment, gastric acid secretion inhibiting, the effect for reducing pepsin activity.It is held back with Schisandra chinensis, Radix Astragali tonifying Qi
Lung can handle deficiency of vital energy cough and asthma, and anaemia, Neuroleptic Leukocytopenia, blood platelet can be handled with Radix Astragali, prepared rehmannia root, Radix Angelicae Sinensis, Radix Paeoniae Alba qi-supplementing, blood-engendering
It reduces, coordinate the unsaturated vapor of Radix Astragali, Poria cocos, honey-fried licorice root, Chinese yam, tonifying spleen and stomach, enhance spleen and stomach function, our transporting is helped to absorb.
Radix Astragali:It is sweet in flavor, tepor, return lung, spleen, liver and kidney channel.Function:Invigorating qi for consolidating superficies, arrest sweating admittedly take off, modern research shows that:It is yellow
Stilbene has enhancing immunity of organism work(containing the various trace elements such as saponin, sucrose, polysaccharide, a variety of amino acid, folic acid and selenium, zinc, copper
Energy;With the ability for promoting virus induction and itself inducement interferon, and Radix Astragali can make spleen entoplasm hyperplasia, promote antibody
Synthesis;Liver protecting promotees haemocyte and generates, and increases the level of CAMP, IGM, IGE in blood, enhancing phagocytosis and sterilizing ability;Radix Astragali
The selenium being rich in is the constituent of glutathione peroxidase (GSH-Px), contains 4 gram atom selenium in every mole of GSH-Px, this
The effect of enzyme is the redox reaction of catalysed reductive glutathione (GSH) and peroxide, is turned into so antioxygen can be played
With being important free radical scavenger (being 50--500 times of vitamin E) has very strong anti-aging anti-stress effect, is equipped with
Radix Codonopsis, red ginseng, Chinese yam, Poria cocos agitate QI of the spleen and stomach, and under upper defeated lung and kidney, operating are infinite.
Sealwort:It is sweet in flavor, mild-natured, returns spleen, lung, kidney channel.Function:Boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.Modern study table
Bright, sealwort contains a large amount of steroid saponins, can enhance cardiac contractile force, increases coronary blood flow, reduces blood pressure and blood glucose, carries
High body immunity can be improved the fecundity of male, promote essence to delay the aging of body, and the amino acid containing there are many
Protonatomic mass improves Semen non-liquefaction etc.;It can also be used for the tune of sex dysfunction such as impotence, premature ejaculation caused by cloudy smart virtual loss
Reason.Sealwort invigorating spleen and kidney, benefiting essence-blood, be equipped with Radix Angelicae Sinensis, Radix Paeoniae Alba assist sealwort enrich blood, be equipped with Poria cocos, Chinese yam mend without hindering taste.Match
With Radix Astragali, red ginseng, Radix Codonopsis, the power of bowl spares coke increases, and is equipped with radix rehmanniae preparata, Semen Cuscutae, matrimony vine, dogwood fruit, raspberry, mulberries, He Shou
The power that crow specializes in lower coke is male, supplements essence and blood, the liver kidney people having the same aspiration and interest, tonifying both YIN and YANG.
Dogwood fruit:Sour, puckery, tepor enters liver and kidney channel, function:It tonifies the liver and kidney, puckery final minification is urinated, consolidating channel for hemostasis, and arrest sweating is solid
It is de-, modern research shows that:With increasing leukocyte, diuretic antihypertensive effect has enhancing to make the non-specific immune function of body
With the phagocytic function and increasing leukocyte of macrophage can be promoted;Promote lymphocyte transformation, improve immune function, adjustment is exempted from
Epidemic disease balances, and has apparent hypoglycemic effect;It can inhibit platelet aggregation, antithrombus formation;Myocardial contractive power can be enhanced, expand periphery
Blood vessel, and blood pressure can be adjusted;Cardiac pumping function is remarkably reinforced, and has Antishock function;Also there is antibacterial, antiviral, anti-
The effects that scorching, antitumor, diuresis, antifatigue, anti-aging, enhancing memory.It is equipped with Radix Codonopsis, Radix Astragali, red ginseng, matrimony vine, radix rehmanniae preparata, Huang
The power of essence, Yin-nourishing and Qi-supplementing, adjusting and reinforcing liver and kidney, nourishing liver and kidney, metaplasia is male.
Red ginseng:Sweet in flavor, slight bitter, it is warm-natured, flat.Returns spleen, lung channel, the heart channel of Hang-Shaoyin, function:It reinforces vital energy, recuperating depleted yang, QI invigorating are taken the photograph
Blood.Modern research shows that red ginseng has brain healthy, analgesia, cancer-resisting, strengthen immunity, hypoglycemic, liver protecting, resists
Tired, anti-oxidant and anti-aging improves the content of ferroheme in blood, adjusts the effects that effect of central nervous system.
Radix rehmanniae preparata:It is sweet in flavor, tepor.Return liver and kidney channel, function:It enriches blood yin-nourishing, life essence-filling, marrow-benefitting.Prepared rehmannia root containing mannitol, Catalpol,
Stigmasterol, alkaloid, aliphatic acid, glucose, stachyose, arginine, rehmanin, vitamin A and irony etc..Have cardiac stimulant diuresis and
The effect for promoting the functions such as interrenall gland and sexual gland also prevents aging and improves the effect of neural reflex function.It is equipped with
Sealwort, Semen Cuscutae, matrimony vine, dogwood fruit, raspberry, mulberries, the fleece-flower root, Schisandra chinensis supplying vital essence and marrow, nourishing the blood and yin, the liver kidney people having the same aspiration and interest,
Fill up negative and positive.
The root bark of tree peony:Acrid flavour is bitter, cool.Enter the heart, liver and kidney channel.Function:Clearing heat and cooling blood, it is promoting blood circulation and removing blood stasis, modern research shows that tree peony
Skin has antibacterial, anti-inflammatory, antiallergy, antitumor, hemostasis, dissolving stasis blood, clearing heat and detoxicating, calm, analgesia, spasmolysis isoreactivity, moreover it is possible to promote
Into monocyte phagocytic function, body specific immune function is improved, increases immune organ weight.It is equipped with Poria cocos, rhizoma alismatis excreting dampness
Turbid, clearind deficient heat is put down its and is won partially, and dampness removing is let out turbid, and anti-tonifying yin is grown greasy, and the temperature of the puckery smart medicine of yang-tonifying processed is puckery, and the light spleen that oozes is wet, helps drugs strengthening spleen
Strong fortune.
Spina date seed:Taste sweet and neutral, thoughts of returning home warp, the spleen channel, Liver Channel, gallbladder channel, function:Antitoxic heart-soothing and sedative;Nourishing the liver;Arrest sweating.Modern study
Show the spina date seed i.e. seed of wild jujube, can make after processing medicinal, it contains alkaloid, a variety of amino acid and metallic element etc.
, there are the illnesss such as restlessness of asrhenia type and insomnia, palpitation with fear palpitation, physically weak spontaneous perspiration in ingredient, the effects that capable of playing antitoxic heart-soothing and sedative, bowl spares nourishing the liver, arrest sweating
Preferable therapeutic effect.Spina date seed has anticonvulsion, calm, syngignoscism.With spina date seed decoction to big white mouse is oral or abdominal cavity
Injection, shows calm and syngignoscism, and no matter daytime or night, spina date seed can show above-mentioned effect.For people
For body, spina date seed is also beneficial to patient and falls asleep as early as possible, and sleep is deepened, and sleeping time extends.Be equipped with Radix Codonopsis, ganoderma lucidum, red ginseng,
Poria cocos replenishing and restoring lung qi, relieving mental strain and helping sleep.
Ganoderma lucidum:Taste sweet, warm;It is mild-natured, the thoughts of returning home, liver, spleen, lung, kidney channel, function:Strengthening the essence protects god, and hard muscle moistens face, and ear is filled in kidney tonifying.
Modern medicine research has shown that, Absorption of Ganoderma lucidum ganoderma lucidum polysaccharide containing organic polymer, triterpenes ganoderic acid, a variety of amino acid, adenosine, biology
The active ingredients such as alkali, vitamin, natural organic germanium and various trace elements, strengthen immunity, organic germanium contained by ganoderma lucidum can lure
It leads human body and generates and activate NK cells and macrophage activity, participate in immunological regulation;Ganoderma lucidum can be by promoting interleukins-
2 generation, the finger of the hematopoietic potential especially leucocyte by promoting the phagocytic function of mononuclear macrophage, by promoting human body
Mark is horizontal, and becomes antitumor, anti-cancer and cancer auxiliary to the inhibiting effect of cancer cell by some of which active ingredient
The preferred agents for the treatment of.Ganoderma lucidum is to human body almost without any toxic side effect.;Liver protection is detoxified, and ganoderma lucidum can promote liver pair
The metabolism of drug, poisonous substance has toxic hepatitis definite curative effect;Promote and adjust immune function.For adult and always
For year people, this promotion and adjustment can obviously slow down aging;Metabolic balance is adjusted, the synthesis of nucleic acid and protein is promoted.It grinds
Study carefully the biosynthesis for showing serum, the nucleic acid of liver and marrow and protein when ganoderma lucidum can promote, therefore can be effectively disease-resistant anti-
Aging;Anti-radical action, ganoderma lucidum polysaccharide have significantly quasi- SOD activity, the free radical of body generation can be significantly removed, to hinder
Only damage of the free radical to body, it is therefore prevented that the peroxidating of fat body protects cell, has delayed cell ageing, ganoderma lucidum polysaccharide energy
Aobvious chopsticks promotes cell nuclear dna synthesis capability, and can increase the division algebraically of cell, to delay the aging of body.;It improves
The effects that immune function, antibacterial;Neurasthenia acts on, and ganoderma lucidum plays the role of maincenter good.Energy exciting motion inhibits,
So that motility is reduced, makes coordinated movement of various economic factors imbalance, dose-dependent town disease effect is presented, ganoderma lucidum has central nervous system relatively strong
Adjustment effect.Be equipped with Radix Codonopsis, spina date seed, red ginseng, Schisandra chinensis, Chinese yam, Poria cocos, the fleece-flower root can mental-tranquilization replenishing and restoring lung qi, peace
Refreshing sleeping, nourishing liver and spleen, supplementing qi and nourishing yin, tonifying spleen lung kidney, and can big tonifying five zang organs vital essence, production of sperm blood, skin table of moistening.
Rhizoma alismatis:It is sweet in flavor cold in nature, return kidney, bladder warp, function:Clearing damp and promoting diuresis expels the heat-evil, and changes turbid lipid-loweringing.《Sheng Nong's herbal classic》It says
It " can support the five internal organs, benefiting energy, fertilizer is strong, long term usage normal hearing and eyesight, not hungry macrobiosis ".Modern research shows that rhizoma alismatis contain be triterpene and
Sesquiterpenoids ingredient also contains diterpene, phytosterol, volatile oil, alkaloid, asparagine, steroline, aliphatic acid, protein
And starch etc., have antithrombotic, reducing blood lipid, reduce blood viscosity, antiatherosclerosis, anti-aging, diuresis, spasmolysis, liver protection,
Anti-inflammatory, immunological regulation, hypoglycemic and other effects.It is turbid to be equipped with Poria cocos, root bark of tree peony excreting dampness, clearind deficient heat is put down its and won partially, and dampness removing is let out turbid, and prevents
Tonifying yin taste is greasy, and the temperature of the puckery smart medicine of yang-tonifying processed is puckery, and the light spleen that oozes is wet, helps the strong fortune of drugs strengthening spleen.
RHIIZOMA DIOSCOREAE from Henan of China:It is sweet in flavor, flat, nontoxic, returns spleen, lung, kidney channel, function:Invigorating spleen and reinforcing stomach, nourishing kidney and replenishing pneuma, benefit lung and restrain cough are modern
Research shows that there is Chinese yam induction to generate interferon, T lymphocytes in human body can be increased, enhance immune function, delaying cell aging,
Enhance the effect of immune function of human body.Its contained choline and lecithin help to improve man memory power, often feeding can body-building it is strong
Body, anti-aging improve digestive function, hypoglycemic, reducing blood lipid, anti-oxidant, anti-aging, antitumor, anti-mutation, promote kidney
Regeneration and Repair adjusts the pharmacological actions such as acid-base balance.It is equipped with Radix Codonopsis, red ginseng, Radix Astragali, Schisandra chinensis, radix polygonati officinalis, Poria cocos, radix rehmanniae preparata, mountain cornel
Meat, Radix Paeoniae Alba, Radix Angelicae Sinensis, spina date seed, Qi-benefiting and heart-nourishing, invigorating the spleen astringent method, enriching yin are quenched the thirst, invigorating spleen to remove dampness, and lung kidney is simultaneously mended, and gas is received in yin-nourishing.
Poria cocos:It is sweet in flavor, light, mild-natured, the thoughts of returning home, lung, spleen, kidney channel, function:Clearing damp and promoting diuresis, invigorating the spleen, calming heart.Modern study table
Bright, Poria cocos has diuresis, calm, antitumor, hypoglycemic, resists myocardial ischemia, and increases myocardial contractive power, promotes immune function, protects
The effects that liver, reduction transaminase, antiulcer.Radix Codonopsis, red ginseng, Radix Astragali, honey-fried licorice root, spina date seed, Chinese yam are equipped with tonifying lung spleen, is calmed the nerves
Surely throb with fear;It is turbid to be equipped with rhizoma alismatis, root bark of tree peony excreting dampness, clearind deficient heat is put down its and is won partially, dampness removing let out it is turbid, and anti-tonifying yin grow it is greasy, the puckery smart medicine of yang-tonifying processed it
Temperature is puckery, and the light spleen that oozes is wet, helps the strong fortune of drugs strengthening spleen.
Fructus schisandrae:Acid, sweet, warm.Return lung, kidney channel, function:Nourishing generate fluid, kidney tonifying nourishing heart restrain astringent method.Modern study
Show:Fructus schisandrae contains schizandrin, malic acid, citric acid, tartaric acid, succinic acid, fat oil, volatile oil, carbohydrate, tree
Fat, vitamin C etc. also contain the trace elements such as tungsten, iron, manganese, zinc, phosphorus, have the excitement of enhancing central nervous system and inhibit
Journey, and be allowed to tend to be balanced mitigates and relieving fatigue to improve body activities function, improves the quality of living and working efficiency;
By reinforcing the contraction power function of heart, adjusts cardiovascular system and reduce blood pressure so as to improve blood circulation;Schisandra chinensis has
Excited respiration improves lung function, and has apparent cough-suppressing phlegm-dispelling functions;Gastric secretion is adjusted, stress ulcer can be inhibited
Generation, so that ulcer index is reduced, and gastric secretion can be inhibited, and excited uterus.Schisandra chinensis has liver-protective effect, can
GPT drops in significant effective, can promote the synthesis of hepatic glycogen, glycometabolism is made to reinforce, and can increase the synthesis of Hepatocyte matter;It can drop
Low serum cholesterol increases protein content in brain and liver, has anti-aging effects.It is equipped with radix polygonati officinalis, Radix Astragali, Chinese yam, sealwort, is grown
Dry pool is withered, nourishing generate fluid, nourishing Yin and promoting production of body fluid, relieving restlessness that clears away heart-fire;It is equipped with dogwood fruit, radix rehmanniae preparata, Chinese yam, matrimony vine, Radix Codonopsis, sealwort, nourishes lung
Kidney, benefiting qi and nourishing yin.
Radix Angelicae Sinensis:It is sweet in flavor, pungent, warm-natured, Return liver, the heart, the spleen channel.Function:Replenishing and activating blood, menstruction regulating and pain relieving relax bowel.Modern times grind
Study carefully and shows:Radix Angelicae Sinensis contains volatile oil and a variety of the essential trace elements of the human bodys, vitamin A, vitamin B12, vitamin E, cobalt amine
7 kinds of amino acid that are plain including needed by human but cannot synthesizing;Contain 23 kinds of inorganic elements simultaneously, wherein 16 kinds are human body institute
It is required, such as calcium, copper, zinc, phosphorus, potassium, iron.Human metabolism can be enhanced;Improve endocrine, it is anti-to treat constipation, enhance stomach
Absorbability;With antiarrhythmic effect, reducing blood lipid and anti-experimental character Atherosclerosis, Radix Angelicae Sinensis polysaccharide can increase outer
All erythrocytes, leucocyte, hemoglobin and bonemarrow nucleated cells number, this effect is especially in peripheral blood cells reduction and bone
It is particularly evident when marrow is suppressed, there is extremely significant hematosis;Effect that is anti-oxidant and removing free radical, Radix Angelicae Sinensis lack brain
Oxygen, Neurons Against Cerebral Ischemia tissue lipid peroxide increases apparent inhibiting effect, and contained ferulic acid, which has, directly to be reduced H2O2 and contain
Amount, and combined with membrane phospholipid acyl ethanol amine, by directly eliminating free radical, inhibit the antagonisms such as oxidation reaction and radical reaction certainly
Damage by base to tissue, to delaying senility certain effect.;Radix Angelicae Sinensis can expand scalp capillary, promote blood circulation, and prevent
Control alopecia and white hair.It is equipped with Radix Codonopsis, red ginseng, Radix Astragali, Schisandra chinensis, radix polygonati officinalis, Poria cocos, radix rehmanniae preparata, dogwood fruit, Radix Paeoniae Alba, Chinese yam, wild jujube
Benevolence, Qi-benefiting and heart-nourishing is qi-blood tonifying, and invigorating the spleen astringent method, enriching yin is quenched the thirst, invigorating spleen to remove dampness, and lung kidney is simultaneously mended, and gas is received in yin-nourishing.
Semen Cuscutae:Acrid flavour, sweet, mild-natured, Return liver, kidney, the spleen channel.Function:It tonifies the liver and kidney, astringent sperm contracting urine, tocolysis, improving eyesight, only
It rushes down.Modern research shows that:Semen Cuscutae more contains containing alkaloid, anthraquinone, cumarin, flavones, glucoside, sterol, tannic acid, carbohydrate etc.
A large amount of trace element such as strontium, molybdenum, calcium, magnesium, iron, manganese, zinc, copper and a variety of amino acid, can promote human lymphocyte
Breeder reaction effectively improves the immunity of body, and the ability for resisting virus greatly enhances.In addition, the vitamin A that Semen Cuscutae is rich in
It is also beneficial to enhancing human body constitution.Semen Cuscutae has the fecundity of enhancing adult men and women's property, this is because institute in Semen Cuscutae
The effect of Flavonoid substances contained can play the role of similar estrogen, and women can play maintenance uterus and ovary after taking.
In addition, activity and survival rate that male takes sperm after Semen Cuscutae can be greatly improved;Semen Cuscutae has certain suppression
The ability of cancer cell processed can reduce the lesion of cancer cell;It can be effectively reduced blood fat and blood glucose, Semen Cuscutae flavonoid is to freedom
The clearance rate of base is very high, and oxidation activity is better than vitamin C, is a kind of natural effective free radical scavenger, has anti-oxidant, resists
Apoptosis, anti-aging effects;It is equipped with sealwort, Chinese yam, radix rehmanniae preparata, matrimony vine, dogwood fruit, raspberry, mulberries, the fleece-flower root, Schisandra chinensis, kidney tonifying
Establishing-Yang, kidney tonifying gas, establishing-Yang road help spirit, light waist foot, supplying vital essence and marrow, nourishing the blood and yin, and the liver kidney people having the same aspiration and interest fills up negative and positive.
Matrimony vine:Sweet and neutral.Return liver and kidney channel, function:Tonifying kidney and benefiting sperm nourishes the liver to improve visual acuity, and blood-enriching tranquillizing promotes the production of body fluid to quench thirst, and moistening lung stops
Cough.Modern research shows that:The fruit of Chinese wolfberry is rich in matrimony vine proteoglycan, carrotene, glycine betaine, vitamin A, vitamin B1, vitamin
C, the multiple nutritional components such as calcium, phosphorus, iron have and increase leukocyte activity, promote the pharmacological action of liver cell new life, can also drop
The effects that blood pressure, hypoglycemic, reducing blood lipid, strengthen immunity, tool liver protection, antifatigue, anti-aging.Be equipped with sealwort, Radix Astragali, radix polygonati officinalis,
Ganoderma lucidum, Radix Angelicae Sinensis, Radix Paeoniae Alba, Chinese yam, radix rehmanniae preparata, Semen Cuscutae, matrimony vine, dogwood fruit, raspberry, mulberries, the fleece-flower root, Schisandra chinensis clear liver bright
Mesh raises qi and blood, warm human body, nourshing kidney benefit essence, nourishing blood and liver, tonifying kidney and strengthening yang, and strengthening the spleen and stomach helps spirit, light waist foot to mend essence and fill out
Marrow, nourishing the blood and yin, the liver kidney people having the same aspiration and interest fill up negative and positive, tonify the liver and kidney, improving eyesight is preserved youthful looks.
Mulberries:It is sweet in flavor sour, cold in nature, enter lung, liver, kidney, large intestine channel, function:Liver-kidney tonifying, UFA eyesight, stops ease constipation of promoting the production of body fluid
Thirsty removing toxic substances, beauty treatment.Modern research shows that:It is more that mulberries contain 16 kinds of amino acid such as Lys, Glu, His and B1, B2, B3, C, E etc.
Kind of vitamin and a variety of organic acids, also contain the mineral elements such as iron, zinc, calcium, phosphorus and carrotene, cellulose, pectin, glucose,
The ingredients such as sucrose, fructose have and adjust immune, promotion hematopoietic growth, anti-mutagenesis, anti-aging, hypoglycemic, reducing blood lipid, shield
Liver, improve reproduction inferior health, etc. health-care effects, be equipped with sealwort, Radix Astragali, radix polygonati officinalis, ganoderma lucidum, Radix Angelicae Sinensis, Radix Paeoniae Alba, Chinese yam, radix rehmanniae preparata, Tu thread
Son, matrimony vine, dogwood fruit, raspberry, the fleece-flower root, Schisandra chinensis clear liver and improve vision, raise qi and blood, warm human body, nourshing kidney benefit essence, blood-nourishing
Soft liver, tonifying kidney and strengthening yang, strengthening the spleen and stomach help spirit, light waist foot, supplying vital essence and marrow, nourishing the blood and yin, and the liver kidney people having the same aspiration and interest fills up negative and positive, help liver
Kidney, improving eyesight are preserved youthful looks, and are nourished cloudy blood, black hair of reinforcing the kidney, are relaxed bowel.
Raspberry:It is sweet in flavor, sour, it is warm-natured.Return liver, kidney, bladder warp, function:Supplementing the kidney to control the nocturnal contracting urine, nourishes the liver to improve visual acuity.Modern times doctor
It learns studies have shown that containing citric acid, salicylic acid, malic acid, vitamin C, vitamin A, glucose, volatile oil etc. in raspberry.
With memory, anti-aging, antineoplastic action is reinforced, the water of the LHRL of hypothalamus, hypophysis LH, FSH and sexual gland E2 can be reduced
It is flat, increase testosterone levels, its regulating and controlling effect to gonad axis, be equipped with sealwort, Radix Astragali, radix polygonati officinalis, ganoderma lucidum, Radix Angelicae Sinensis, Radix Paeoniae Alba, Chinese yam,
Radix rehmanniae preparata, mulberries, Semen Cuscutae, matrimony vine, dogwood fruit, the fleece-flower root, Schisandra chinensis clear liver and improve vision, raise qi and blood, warm human body, nourshing kidney benefit
Essence tonifies the liver and kidney, and improving eyesight is preserved youthful looks, and nourishes cloudy blood, black hair of reinforcing the kidney, adds smart mends marrow, dredges profit kidney qi.
Prepared fleece flower root:Bitter sweet is puckery, tepor, Return liver, kidney, large intestine channel, function:Help essence and blood, black beard and hair, strengthening the bones and muscles, tonifying liver
Kidney, modern research shows that:Fleece-flower root main active has Anthraquinones, diphenylethylene, phospholipid, flavonoids and phenols, can
For reducing blood lipid, anti-aging, immunity, intelligence development, anti-aging, antiatherosclerosis, raising body's immunity are improved, is matched
With sealwort, Radix Astragali, radix polygonati officinalis, ganoderma lucidum, Radix Angelicae Sinensis, Radix Paeoniae Alba, Chinese yam, radix rehmanniae preparata, mulberries, Semen Cuscutae, matrimony vine, dogwood fruit, Schisandra chinensis, nourshing kidney
Mend essence, tonify the liver and kidney, improving eyesight is preserved youthful looks, and nourishes cloudy blood, the moon essence of nourishing the liver and kidney, but residence helps sun among enriching yin, it is cloudy obtain it is positive help, then
Cloudy blood must support, and blood vessels must be transported, the disadvantage of absolutely not greasy stagnant lingering diarrhea.Though there is the greasy stagnant product of enriching yin, after steaming nine solarizations through nine, pharmacological property is able to
Transformation, function have changed, and sun of residing in cloudy obtains the property of hair tonic.
Radix Paeoniae Alba:Bitter, acid, cold nature, function:Nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver analgesic, suppressing liver-YANG, modern study
Show:There is anti-inflammatory, analgesia, liver protection, adjusting to exempt from for principle active component Paeoniflorin, albiflorin and total glucoside in Radix Paeoniae Alba
The effects that epidemic disease, antidepression, has antioxidant activity, adjusts immune system, the physiological activity such as protection cardiovascular system, Radix Paeoniae Alba is to liver
Macrophage has protective effect, and the phagocytosis of chamber macrophage can be made to increase by 30%.Be equipped with sealwort, Radix Astragali, radix polygonati officinalis, ganoderma lucidum,
Radix Angelicae Sinensis, RADIX POLYGONI MULTIFLORI PREPARATA, Chinese yam, radix rehmanniae preparata, mulberries, Semen Cuscutae, matrimony vine, dogwood fruit, Schisandra chinensis, honey-fried licorice root, sour-sweet herbs nourishing yin are enriched blood soft
Liver delays soft liver with invigorating the spleen, and during emergency is to adjust, nourshing kidney mends essence, tonifies the liver and kidney, and nourishes cloudy blood, and the moon of nourishing the liver and kidney is smart, but enriching yin it
Middle residence helps sun, cloudy positive to help, then cloudy blood must support, and blood vessels must be transported, the disadvantage of absolutely not greasy stagnant lingering diarrhea.
Radix polygonati officinalis:It is mild-natured, it is sweet in flavor, enter the warp of lung stomach two, function:Nourishing yin to moisten dryness promotes the production of body fluid to quench thirst.Modern research shows that:Radix polygonati officinalis carries
Flavonoid substances are taken to be combined to form a kind of novel substance with mulberry-leaf extract 1-Deoxynojirimycin --- wash the clear sugar element (cics) of pancreas, tool
There is the effects that hypoglycemic, blood fat, blood pressure;Radix polygonati officinalis methanolic extract has the blood glucose value of adrenaline induced hyperglycemia mice bright
Aobvious reduction effect, and show the tendency for improving resistance to sugared function;Polysaccharide, Alphalin in radix polygonati officinalis and niacin, Wheat Protein
Human disease resistance can be enhanced, body immunity is adjusted, inhibit the growth of tumour, delay aging.Containing cardiac glycoside, alkaloid and
Retinoid substance and glue polysaccharide --- radix polygonati officinalis mucopolysaccharide, radix polygonati officinalis levulan etc., having improves myocardial anoxia and adrenal gland skin
Matter hormone-like effect.It is equipped with can grow dry pool withered, nourishing generate fluid, the yin-nourishing life of Schisandra chinensis, Radix Astragali, Chinese yam, sealwort, dogwood fruit, mulberries
Tianjin, relieving restlessness that clears away heart-fire;Help the five internal organs nourish qi and blood, put down and mend and moisten, and remove wind-heat.
Honey-fried licorice root:Sweet and neutral.The thoughts of returning home, spleen, lung, stomach, function:Tonifying spleen and stomach, Yiqi and vein recovery, modern research shows that:Radix Glycyrrhizae
Containing a variety of chemical compositions such as glycyrrhizin, enoxolone, licorice polysaccharide, there is anti-inflammatory and anti-allergy action, be adjusted
Body's immunity, antitumor and analgesic effect, Radix Glycyrrhizae have similar adrenocortical hormones fuction.To hydrochloric acid in gastric juice caused by histamine
Hypersecretion has inhibiting effect;And there is antiacid and alleviation gastrointestinal smooth muscle spasm effect honey-fried licorice root to contain glycyrrhizin, Radix Glycyrrhizae time
A variety of chemical compositions such as acid, licorice polysaccharide have anti-inflammatory and anti-allergy action, and body's immunity is adjusted, antitumor
And analgesic effect.It is equipped with entire formula, coordinating the drug actions of a prescription is closed with the medicine phases of tonifying spleen and stomach, and the power of metaplasia is infinite.
The present invention is based on Traditional Chinese medical theories, provide a kind of equilibrium between yin and yang improvement sub-health state raising people maintaining human body
Anti- organism fatigue drug of anti-aging of body function and preparation method thereof.No matter formula men and women can be used, formula is all adopted
With Chinese traditional medicine composition, scientific and reasonable preparation method, directly acts on body, pharmacological property is mild, uses by rear drug effect for oral administration in addition
Convenient, curative effect is stablized.With the remarkable result for improving asthenic symptoms, it is weary to be effectively improved the tired body of god, has a dizzy spell, soreness and weakness of waist and knees, chilly
Limb is cold, and not to the utmost, failure of memory, insomnia and dreamful sleep, alopecia or poliosis, easy catching a cold, micro- cough shortness of breath are eaten for night pollakiuria or the heeltap
It is intended to decline, the early ageing such as sexual hypoesthesia, aging phenomenon, this product can slow down aging, and there is kidney tonifying, essence replenishing, nourishing liver and kidney, QI invigorating to be good for
Spleen, strengthen immunity, antifatigue, enhancing taste dampness elimination function and human temperature function inhibit internal peroxide generation, improve
SOD is horizontal, controls injury response in free radical body, improves caused by each organ-tissue function reduction " hypercoagulative state ";From basic
Upper conditioning and enhancing immunity of organisms.This product can improve and enhance body to greatest extent while adjusting tonifying lung spleen kidney yin sun
Function, integrated regulation improve constitution, improve immunity of organisms, enhance a surname's hair of taste dampness elimination function, kidney yang temperature function, lung qi
Respectful drop function fundamentally improves and enhances body function, maintains the equilibrium between yin and yang of human body and improves sub-health state, to reach
Slow down aging antifatigue purpose.
There is following significant advantage compared with existing similar technique:
One, treating both manifestation and root cause of disease.Lung is the day of the five internal organs, and spleen is the mother of bones of the body collectively, and kidney is the root of life, so processing aging fatigue
Key is that the coordination of lung spleen kidney yin sun.This product can improve and enhance to greatest extent while adjusting tonifying lung spleen kidney yin sun
Body function, integrated regulation improve constitution, improve immunity of organisms, enhancing taste dampness elimination function, kidney yang temperature function, lung qi
Function drops in Xuan Fasu, fundamentally improves and enhance body function, maintains the equilibrium between yin and yang of human body and improves sub-health state, to
Achieve the purpose that slow down aging antifatigue.
Two, the spleen kidney people having the same aspiration and interest, Yin Yang balancing.This product breaks the function of traditional a certain internal organs of simple help or a few internal organs,
With " treatment of deficiency-syndrome by reinforcement ", " damage person's benefit ", " diseases caused by over-strain should be treated by warming ", " shape deficiency person, warming with drugs of thick nature;Insufficiency of essence person, tonifying with drugs of thick flavor " is base
This conditioning principle, it is key to adjust tonifying spleen kidney, its energy integrated regulation improves body constitution, improves immunity of organisms, and adjustment negative and positive are flat
Weighing apparatus improves sub-health state and slows down aging.
Three, many medicine comprehensive improvements are broken the normal procedure tactics, it is to use a variety of drugs, is launched an attack comprehensively, and constitution, raising immunity of organism are improved
Power is corrected, and sub-health state is improved, antifatigue to achieve the purpose that slow down aging.
Four, from the spleen kidney people having the same aspiration and interest, the root of yin and yang imbalance is started with, and is developed for essence and complication, with numerous medicines
Digestion, immune system and internal system are improved comprehensively, from improving and enhancing body function, changed to integrated regulation
Kind constitution, improves immunity of organisms, is finally reached the equilibrium between yin and yang for maintaining human body, improves sub-health state, slows down aging anti-tired
The purpose of labor.
Five, inhibit internal peroxide to generate, improve SOD levels, control injury response in free radical body, improve each organ
Caused by function of organization declines " hypercoagulative state ".This product can from the stabilization of the metabolism of whole body and interior environment it is whole in terms of on reach
It is acted on to health care.
Six, this product is entirely traditional Chinese medicine, and pharmacological property is mild, easy to use, and curative effect is stablized.This formula is verified can be fine
Ground improves human body sub-health status, adjusts function of human body, slows down aging antifatigue.
Specific implementation mode
With reference to embodiment, the present invention is furture elucidated.These embodiments be interpreted as being merely to illustrate the present invention and
It is not intended to limit the scope of the invention.After having read the content of the invention recorded, those skilled in the art can be with
The present invention is made various changes or modifications, these equivalence changes and modification equally fall into model defined by claims of the present invention
It encloses.
Embodiment 1:A kind of drug for anti-aging, including following components:Radix Codonopsis 100g, Radix Astragali 100g, dogwood fruit
100g, radix rehmanniae preparata 100g, matrimony vine 100g, mulberries 100g, raspberry 100g, fleece-flower root 100g and radix polygonati officinalis 100g.
Embodiment 2:A kind of drug for anti-aging, including following components:Radix Codonopsis 150g, Radix Astragali 120g, dogwood fruit
120g, radix rehmanniae preparata 120g, matrimony vine 120g, mulberries 120g, raspberry 120g, fleece-flower root 120g and radix polygonati officinalis 120g.
Embodiment 3:A kind of drug for anti-aging, including following components:Radix Codonopsis 200g, Radix Astragali 150g, dogwood fruit
150g, radix rehmanniae preparata 150g, matrimony vine 150g, mulberries 150g, raspberry 150g, fleece-flower root 150g and radix polygonati officinalis 150g.
Embodiment 4:A kind of drug for anti-aging, including following components:Radix Codonopsis 100g, Radix Astragali 100g, dogwood fruit
100g, radix rehmanniae preparata 100g, matrimony vine 100g, mulberries 100g, raspberry 100g, fleece-flower root 100g, radix polygonati officinalis 100g, red ginseng 80g, Semen Cuscutae
100g, sealwort 100g, RHIIZOMA DIOSCOREAE from Henan of China 100g, fructus schisandrae 100g, spina date seed 100g and ganoderma lucidum 100g.
Embodiment 5:A kind of drug for anti-aging, including following components:Radix Codonopsis 150g, Radix Astragali 120g, dogwood fruit
120g, radix rehmanniae preparata 120g, matrimony vine 120g, mulberries 120g, raspberry 120g, fleece-flower root 120g, radix polygonati officinalis 120g, red ginseng 100g, Tu
Sub- 120g, sealwort 120g, RHIIZOMA DIOSCOREAE from Henan of China 120g, fructus schisandrae 120g, spina date seed 120g and ganoderma lucidum 110g.
Embodiment 6:A kind of drug for anti-aging, including following components:Radix Codonopsis 200g, Radix Astragali 150g, dogwood fruit
150g, radix rehmanniae preparata 150g, matrimony vine 150g, mulberries 150g, raspberry 150g, fleece-flower root 150g, radix polygonati officinalis 150g, red ginseng 120g, Tu
Sub- 150g, sealwort 150g, RHIIZOMA DIOSCOREAE from Henan of China 150g, fructus schisandrae 150g, spina date seed 150g and ganoderma lucidum 120g.
Embodiment 7:A kind of drug for anti-aging, including following components:Radix Codonopsis 150g, red ginseng 150g, Radix Astragali
150g, sealwort 150g, dogwood fruit 150g, radix rehmanniae preparata 150g, root bark of tree peony 150g, spina date seed 150g, rhizoma alismatis 150g, Chinese yam 150g, Poria cocos
150g, matrimony vine 150g, fructus schisandrae 150g, mulberries 150g, Semen Cuscutae 150g, raspberry 150g, prepared fleece flower root 150g, Radix Angelicae Sinensis
150g, Radix Paeoniae Alba 150g, ganoderma lucidum 120g, honey-fried licorice root 100g and radix polygonati officinalis 120g.
Embodiment 8:A kind of drug for anti-aging, including following components:Radix Codonopsis 120g, red ginseng 100g, Radix Astragali
120g, sealwort 120g, dogwood fruit 120g, radix rehmanniae preparata 120g, root bark of tree peony 120g, spina date seed 120g, rhizoma alismatis 120g, Chinese yam 120g, Poria cocos
120g, matrimony vine 120g, fructus schisandrae 120g, mulberries 120g, Semen Cuscutae 120g, raspberry 120g, prepared fleece flower root 120g, Radix Angelicae Sinensis
120g, ganoderma lucidum 110g, Radix Paeoniae Alba 120g, honey-fried licorice root 100g and radix polygonati officinalis 100g.
Embodiment 9:A kind of drug for anti-aging, including following components:Radix Codonopsis 100g, red ginseng 80g, Radix Astragali
100g, sealwort 100g, dogwood fruit 100g, radix rehmanniae preparata 100g, root bark of tree peony 100g, spina date seed 100g, rhizoma alismatis 100g, Chinese yam 100g, Poria cocos
100g, matrimony vine 100g, fructus schisandrae 100g, mulberries 100g, Semen Cuscutae 100g, raspberry 100g, prepared fleece flower root 100g, Radix Angelicae Sinensis
100g, ganoderma lucidum 100g, Radix Paeoniae Alba 100g, honey-fried licorice root 100g and radix polygonati officinalis 100g.
When prepared by said medicine, the specific steps are:
Respectively through over cleaning, the techniques such as drying are ground into thin respectively under conditions of sterile, dustless for step 1, all raw materials
It is last for use;
Step 2 is sieved with l20 mesh and sieves medicinal powder respectively, and is mixed into mixed powder by the blending of weighing of formula dosage
For use;
Mixed powder is placed in machine for decocting Chinese traditional herb medicines by step 3, using distillation, is stewed in clear soup, is decocted three kinds of methods and is soaked successively
Merging is proposed, juice is taken to stay slag, the dregs of a decoction are decocted again, are boiled for the first time half an hour, filters, adds water to cook for the second time 20 minutes,
Third time adds water to cook 20 minutes, merges juice, is filtered with liquid pass filter spare;
Step 4, purification extracting solution need to use purified treatment to reduce the precipitation in liquid, stand 2h purifications, and again
Secondary filtering;
Extracting solution after step 5, thickening-purification technology:With concentration in extracting solution injection economic benefits and social benefits vacuum energy-saving inspissator after filtration
Degree, cocnentration factor are 1.041-1.125, and in concentration, water accounts for 50%~51.1% in the liquid medicine after concentration, and medicament accounts for 48.9%
~50%, then be added after simple syrup mixing, progress suitably concentration up to the medicine for anti-aging with the ratio of sugared content 68%
Object.
The drug daily measures 30-80ml, can also continue dry chemical conversion granule or continue heating concentration be boiled into lotion,
The either dosage forms such as pharmaceutically acceptable tablet, capsule.
Substantive distinguishing features, validity and safety in order to better illustrate the present invention pass through the above-mentioned formula of the present invention
The experiment for many years of the present inventor and periphery friends and family, experiment disease example up to the present have 262, male 142, women
120, the age is between 21 years old to 80 years old, wherein there is within 21 years old to 50 years old 45, has 98 within 50 years old to 60 years old, has 84 within 60 years old to 70 years old
Example, there is 35 for 70 years old or more.The course of disease is 80 within 1 year, 1-5 131,5-8 44,8 years or more 7.There is hypertension 33
Example, Treating 30 Cases of Coronary Heart Disease, slow branch 18, apoplexy sequelae 9, alopecia areata and alopecia 5, sex dysfunction 15, neurasthenia and
Insomnia 8, test effect is as follows:
Invalid 5:Account for the 1.91% of case.5 patients, wherein 3, after taking medicine 5 days, feels and be difficult to endure this formula
Taste is stopped using, when rear half a month follow-up, inquiry, which is learnt, have been deactivated 10 days, and is reluctant to use again;Other 2 all because old complaint is prominent
Hair is stopped using.
Effective 256, account for the 97.7% of case.239 are wherein cured, the 91.2% of case is accounted for.
Above-mentioned data is particularly directed to due to Spleen-Qi Deficiency, insufficiency of the spleen-yang, kidney-yang deficiency, the insufficiency of both the spleen and the kindey, kidney-yin deficiency, the deficiency of liver-yin and kidney-yin,
The insufficiency of heart and spleen, insufficiency of lung-QI,deficiency of lung-QI is hypofunction of both the spleen and the lung, kidney essence deficiency, wherein the tired body of god caused by a card or more cards is weary, has a dizzy spell, waist
Knees soreness, aversion to cold and cold limbs, night pollakiuria or the heeltap not to the utmost, failure of memory, insomnia and dreamful sleep, alopecia or poliosis, easy catching a cold,
Micro- cough shortness of breath, anorexia, the symptoms of aging such as sexual hypoesthesia.
Diagnostic criteria:According to national combination of Chinese tradiational and Western medicine asthenic symptoms with disease of old people research Professional Committee on May 13rd, 1986
The dialectical reference standard of traditional Chinese medicine deficiency-syndrome that formulation was held in Zhengzhou, henan to 17 days, referring to 10 phases in 1986《The combination of Chinese tradiational and Western medicine is miscellaneous
The dialectical reference standard of will traditional Chinese medicine deficiency-syndrome》
Judge healing, effective and invalid standard:Treat time limit limitation longest 6 months;Recovery from illness:Cardinal symptom, sign disappear
It loses, related experiment detection is normal.It is effective:Cardinal symptom disappears, and minor symptom improves, and sign improves apparent, related laboratory inspection
It surveys normal or improves;It improves:Cardinal symptom, sign improve, and related experimental check improves or stablizes constant;In vain:Be not achieved with
Upper standard person.
The model case of following numerical example is now lifted to prove:
Case one:Liu, man, 24 years old, university student.
Main suit:Often feel that body is tired, receives difference, study is tired, without spirit, failure of memory, usually insomnia and when feel four
Myasthenia of limbs, soreness and weakness of waist and knees, and have 5 years as long as masturbation histories, frequency is very high.Sallow complexion, no god, pale tongue is micro- fat, slow and sunken pulse.
Diagnosis:Speen-kidney dificiency, deficiency of kidney-essence.Then it is replenished qi to invigorate the spleen with we, kidney tonifying, essence replenishing gives birth to marrow.
Usage and dosage:It takes orally each 30-50ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.With this
After being formulated January, sleep quality greatly improves, and memory improves, and tired out sense gradually subsides, and soreness and weakness of waist and knees is eliminated, and feels that spirit is relaxed
Freely, it is in a cheerful frame of mind, it is advised to continue to take January, all cards are eliminated, recovery from illness.
Case two:Mr. Wang, female, 21 years old, office worker.
Main suit:It stays up late, has a dizzy spell for a long time, aversion to cold and cold limbs, without spirit, insomnia and dreamful sleep, soreness and weakness of waist and knees, alopecia, menstruation
The few color of amount is light, and menstrual period usually postpone delay pain.Complexion is whitened, and pale tongue tongue is few, deep-slow pulse.
Diagnosis:The insufficiency of both the spleen and the kindey, asthenia of essence and blood
Usage and dosage:It takes orally each 30-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.With this
After being formulated January, complexion turns red, and sleep quality greatly improves, and tired out sense subsides, and soreness and weakness of waist and knees is eliminated, creeping chill decline, menstrual flow color
Increase, carry out dysmenorrhoea and subtract, alopecia is reduced, and menstrual period are delayed as usual.It is advised to continue to take the 2-3 months, all cards are eliminated, recovery from illness.
Case three:Lee, female, 45 years old, teacher.
Main suit:Patient is weak for many years, and for many years, palpitation and short breath, alopecia is serious for no appetite, and nearly 1 week white hair increases, and normal shape is trembled with fear limb
Cold, soreness and weakness of waist and knees and crymodynia or the cold pendant of lower abdomen are keenly felt, and irregular eating, with constipation.
Diagnosis:It is weakness of the spleen and the stomach, it is yin-yang deficiency
Usage and dosage:It takes orally each 30-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.With this
After being formulated January, symptom is relieved, and alopecia stops, and appetite increases, and diet is gradually normal, feels that functions of intestines and stomach restores, constipation is slow
Solution, shape is trembled with fear, and limb is cold, and soreness and weakness of waist and knees symptom takes a turn for the better, and the cold pendant pain of lower abdomen is as usual.It is advised to continue to take the 2-3 months, all cards are eliminated, and are fullyed recover from an illness
More.
Case four:Poplar, man, 50 years old, civil servant.
Main suit:It is long-term dizzy, with hypopsia, often feel soreness of waist and ache in legs, work is tired, sexual hypoesthesia, easy catching a cold.
Diagnosis:The deficiency of liver-yin and kidney-yin defends unsaturated vapor
Usage and dosage:It takes orally each 30-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.It takes
After this formula 2 months, physical condition significantly improves, and especially soreness of waist and ache in legs is eliminated, and eyesight is obviously restored, and feels lighter than before upstairs
Pine understands that mostly sexual life has clear improvement than before, also no longer as so tired before before reading newspaper ratio.Advise its after
Continuous to take 2 months, all cards are eliminated, recovery from illness.
Case five:Week certain, man, 49 years old, office worker.
Main suit:The long-term tired body of god is weary, soreness and weakness of waist and knees, night pollakiuria, often feels tired, has a dizzy spell, diet is not fragrant, Fu Qisheng
Unable to do what one wishes, premature ejaculation living.
Diagnosis:Kidney insufficiency, transporting and transforming function of the spleen and stomach are powerless
Usage and dosage:It takes orally each 30-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.It takes
Physical condition significantly improves this formula 1 after half a month, and especially refreshing tired body is weary, and the symptom of soreness and weakness of waist and knees substantially eliminates, and feels ratio
Before easily, sexual life has clear improvement, time lengthening.It is advised to continue to take 2 months, all cards are eliminated, recovery from illness.
Points for attention:
1. taking the pungent raw food of we's taboo grows greasy product, diet low sugar, low fat, less salt.
2. this product avoids solarization and high temperatures and humidity, shady and cool drying is answered to be sealed.
Case six:
Syndrome of deficiency of spleen qi example:
Money, female, 15 years old, student.
Main suit:Its mother of patient state its from infancy when develop bad, up to now, the short flesh of body is thin, and slightly action is felt tired
Shortness of breath is disinclined to play, reading and writing slightly mistake, that is, feels that eyes take out pain, can not continue to learn.Feeble pulse is soft, pale tongue, and Mian Se Koushi are white,
Mesh white of the eye is excessive, and when stool is shapeless, receives difference.
Diagnosis:It is weakness of the spleen and the stomach, damage of spleen-QI
Usage and dosage:It takes orally each 30-50ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.With this
Formula is after 20 days, and symptom is obviously eliminated, and appetite increases, and after January, often meal can eat 2 bowls, and complexion is gradually ruddy, in high spirits,
It likes to play dynamic, eyesight improves, and can continue reading and writing.It is advised to continue to take the 2-3 months, all cards are eliminated, recovery from illness.
Case seven:
Syndrome of deficiency of spleen yang example:
Lee, man, 35 years old, civil servant.
Main suit:It feels, is short of physical strength in this year, have a dizzy spell, often low fever, aversion to cold and cold limbs, spontaneous perspiration, back sweat is more,
It changes one's clothes for several times daily, often sense is tired, drowsiness, loses the appetite, and has bearing down in abdomen, is often desire to defecate, but measures few unsmooth, enuresis nocturna
Frequency is more, clear long, and pulse condition floats big and soft, and tongue nature is light, and tongue is thin in vain.
Diagnosis:Weakness of spleen-YANG, the sinking of qi of middle-jiao
Usage and dosage:It takes orally each 30-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.With this
After 10 days, low-heat disappears formula, and spontaneous perspiration stops, falling inflation sense mitigation in dizzy and abdomen.After January, aversion to cold and cold limbs substantially eliminates, tired
Labor sense mitigation, drowsiness mitigation, appetite are restored.It is advised to continue to take the 3-4 months, all cards are eliminated, recovery from illness.
Case eight:
Syndrome of deficiency of kidney yang example:
Lee, man, 53 years old, worker.
Main suit:Readme pain in the back is abnormal, often shiver all overs with cold, and four limbs are not warm, and sexual intercourse is not good for many years, dare not big-movement walk,
It dare not bend over to pick up thing, slightly mishap is just in great pain, suffers untold misery, slow and sunken pulse, and tongue is thin white.
Diagnosis:The insufficiency of the kidney yang, it is raw in cold sensation of the genitalia
Usage and dosage:It takes orally each 50-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.With this
Formula is after 25 days, pain relief, can slightly bend over that thing, paces on foot is taken also to accelerate many, one after half a month, chilly limb
Cold to substantially eliminate, pain subtracts greatly.It is advised to continue to take the 3-4 months, all cards are eliminated, recovery from illness.
Case nine:
Syndrome of yang deficiency of spleen and kidney example:
Mr. Wang, female, 33 years old, office worker
Main suit:Mian Se Koushi are white, and it is cold often to feel shape limb of trembling with fear, soreness and weakness of waist and knees, occasionally there is crymodynia in abdomen, diarrhea with undigested food in the stool, and pale tongue is fat or side
There are indentation, white and slippery fur.Deep,thready and forceless pulse.
Diagnosis:The insufficiency of both the spleen and the kindey, it is raw in cold sensation of the genitalia
Usage and dosage:It takes orally each 30-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.With this
After 20 days, creeping chill mitigates formula, and soreness and weakness of waist and knees substantially eliminates, and crymodynia subtracts greatly in abdomen.It is advised to continue to take 2 months, all cards are eliminated, and are fullyed recover from an illness
More.
Case ten:
Syndrome of deficiency of kidney yin example:
Tang, man, 38 years old, individual.
Main suit:Headache and dizzy and weigh, soreness and weakness of waist and knees, dysphoria in chestpalms-soles, hectic fever night sweat, it is apathetic, sleep it is not good enough, food intake is still
It can.Pulse condition is heavy thin, and tongue nature is normally without tongue.
Diagnosis:Kidney-yin deficiency, kidney-KIN being deficient
Usage and dosage:It takes orally each 30-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.With this
After 10 days, headache and dizzy gradually stops formula, soreness and weakness of waist and knees substantially eliminates, and night sweat is eliminated, and dysphoria with smothery sensation mitigates.It is advised to continue to take January,
All cards are eliminated, recovery from illness.
Case 11:
Syndrome of deficiency of lung qi example:
Peng, 18 years old, female, student.
Main suit:Cough and asthma is left after flu, it is touching refractory, look into depauperation.After admission, one meets fatigue, must fall ill.Chang Yi little
Green Dragon soup, erchen tang etc. control it, control send out repeatly repeatly.
Diagnosis:Insufficiency of lung-QI, prolonged illness chronic ill, consumption are hindered healthy tendency, are subtracted resistance day.
Usage and dosage:It takes orally each 30-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.With this
Be formulated half a year after, physically fit, blastoprolepsis, therewith chronic ill also remove, fully recover.
Case 12:
Syndrome of deficiency of both heart and spleen example:
Mr. Wang, female, 33 years old, accounting
Main suit:It had a sleepless night for more than 10 years, it is serious recently.Nearly March carrys out administered before bed time hypnotic, falls asleep and woke up less than 3 hours, the heart after waking up
Throb with fear not peaceful, it is irritated, it cannot fall asleep again.The morning is dizzy, and afternoon, distending pain in the head, had a headache more so at night, and head tendon and vessel is nervous, and neck board is tight
It does not relax, belch is indigestion and loss of appetite, forgetful, and thinking is not easy to concentrate, and is in a very depressed state, and metal fatigue is cold, under soreness of waist band.Small and wiry pulse, tongue nature
It is light greenish blue, greasy and thin fur.
Diagnosis:The insufficiency of heart and spleen, transformation coming from spleen is not prosperous, deficiency of qi and blood, blood not nourishing heart, thus it is confused and worried, on liver-yang
It disturbs, dizzy distending pain is caused by insomnia palpitaition.
Usage and dosage:It takes orally each 30-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.With this
After 10 days, diet increases formula, but still has flatulence after eating, and sleeps about three, four hours, and headache at night has mitigation.After 30 days, diet
Incrementss are big, and stool is normal, and nutrient absorption is preferable, and qi and blood gradually fills, ataraxia, it is advised to continue to take 2 months, and all cards are eliminated, and are fullyed recover from an illness
More.
Case 13:
Syndrome of yin deficiency of liver and kidney example:
Poplar, man, 50 years old, civil servant.
Main suit:It is long-term dizzy, with hypopsia, often feel soreness of waist and ache in legs, work is tired, sexual hypoesthesia, easy catching a cold.
Diagnosis:The deficiency of liver-yin and kidney-yin defends unsaturated vapor
Usage and dosage:It takes orally each 30-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.It takes
After this formula 2 months, physical condition significantly improves, and especially soreness of waist and ache in legs is eliminated, and eyesight is obviously restored, and feels lighter than before upstairs
Pine understands that mostly sexual life has clear improvement than before, also no longer as so tired before before reading newspaper ratio.Advise its after
Continuous to take 2 months, all cards are eliminated, recovery from illness.
Case 14:
Syndrome of yin deficiency of lung and kidney example:
Main suit:Once hectic for many years, was cured.Lung damages Tianjin void, deficiency of the kidney consumption.The nearly several months, involuntary emission, the red tongue of tongue is few, face
White cheekbone is red, and dry cough lacks phlegm, and dry throat and mouth, waist soreness, insomnia and dreamful sleep, dizziness is without god, and impotence and premature ejaculation, arteries and veins is thin and counts.Hospital is multiple
Look into no tuberculosis breaking-out.
Diagnosis:Lung kidney yin liquid virtual loss, disturbance of deficiency-heat inside the body
Usage and dosage:It takes orally each 30-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.It takes
After this formula 20 days, physical condition significantly improves, and colourless cheekbone is red, and dry cough lacks phlegm, dry throat and mouth, and symptom mitigates, and waist soreness loses
Dormancy dreaminess disappears.It is advised to continue to take March, all cards are eliminated, recovery from illness.
Case 15:
The hypofunction of both the spleen and the lung card example:
Chen, man, 28 years old, office worker.
Main suit:Usually brothers are chilly, lassitude hypodynamia, anorexia, loose stool, and micro- cough shortness of breath, the tender tongue of pale tongue is white, feeble pulse.
Diagnosis:It is hypofunction of both the spleen and the lung, it is defeated on the precise and tiny gas of spleen deficiency inability transporting and transforming nutrients from foodstuff, lead to insufficiency of lung-QI
Usage and dosage:It takes orally each 30-80ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.It takes
After half a month, physical condition significantly improves this formula, and especially tired out sense mitigates, and appetite increases, and stool starts forming.Advise its after
Continuous to take 2 months, all cards are eliminated, recovery from illness.
Case 16:
Kidney essence deficiency demonstrate,proves example:
Liu, man, 24 years old, university student.
Main suit:Often feel that body is tired, receives difference, study is tired, and without spirit, failure of memory, the normal empty pain of head is usually had a sleepless night
And when feel weakness of limbs, soreness and weakness of waist and knees, and have 5 years as long as masturbation histories, frequency is very high.Sallow complexion, no god, pale tongue is micro- fat,
Slow and sunken pulse.
Diagnosis:Kidney essence deficiency, speen-kidney dificiency, kidney essense are weak.Then it is replenished qi to invigorate the spleen with we, kidney tonifying, essence replenishing gives birth to marrow.
Usage and dosage:It takes orally each 30-50ML to be taken in morning fasting 2 times a day, sleeps first 1 hour and take at night.With this
After being formulated January, sleep quality greatly improves, and memory improves, and tired out sense gradually subsides, and soreness and weakness of waist and knees is eliminated, and feels that spirit is relaxed
Freely, it is in a cheerful frame of mind, it is advised to continue to take January, all cards are eliminated, recovery from illness.
The above embodiments are only the preferred technical solution of the present invention, and are not construed as the limitation for the present invention, this hair
Technical characteristic in the technical solution that bright protection domain should be recorded with claim, including the technical solution of claim record
Equivalents are protection domain.Equivalent replacement i.e. within this range is improved, also within protection scope of the present invention.
Claims (10)
1. a kind of drug for anti-aging, which is characterized in that including following components by weight:Radix Codonopsis 100-200
Part, 100-150 parts of matrimony vine, 100-150 parts of mulberries, is covered 100-150 parts of Radix Astragali, 100-150 parts of dogwood fruit, 100-150 parts of radix rehmanniae preparata
100-150 parts of 100-150 parts of basin, 100-150 parts of the fleece-flower root and radix polygonati officinalis.
2. drug according to claim 1, which is characterized in that further include following components by weight:Red ginseng 80-
120 parts, 100-150 parts of Semen Cuscutae, 100-150 parts of sealwort, 100-150 parts of RHIIZOMA DIOSCOREAE from Henan of China, 100-150 parts of fructus schisandrae, spina date seed
100-150 parts and 100-120 parts of ganoderma lucidum.
3. drug according to claim 2, which is characterized in that further include following components by weight:Radix Angelicae Sinensis 100-
150 parts, 100-150 parts of Radix Paeoniae Alba, 100-150 parts of the root bark of tree peony, 100-150 parts of rhizoma alismatis, 100-150 parts of Poria cocos and honey-fried licorice root 100-150
Part.
4. drug according to claim 1, it is characterised in that:The fleece-flower root is the fleece-flower root after processing.
5. drug according to claim 2, it is characterised in that:The Chinese yam is RHIIZOMA DIOSCOREAE from Henan of China, and Schisandra chinensis specifically uses north five
Taste.
6. drug according to claim 3, it is characterised in that:The Radix Glycyrrhizae is honey-fried licorice root.
7. drug according to claim 3, it is characterised in that:Medicine is made after extracting working substance to raw material components in the drug
Liquid, particle, plaster or other pharmaceutically acceptable dosage forms.
8. the method for preparing drug described in claim 1-6 any one, which is characterized in that include the following steps:
1)Bulk pharmaceutical chemicals are respectively washed, are dried and are smashed spare;
2)Each bulk pharmaceutical chemicals powder is sieved, mixing of weighing is carried out according to the ratio, obtains mixed powder;
3)Mixed powder is placed in machine for decocting Chinese traditional herb medicines, using distillation, is stewed in clear soup, three kinds of methods is decocted and carries out extraction merging successively,
It takes juice to stay slag, the dregs of a decoction is decocted again, are boiled for the first time half an hour, filter, add water to cook for the second time 20 minutes, third time adds
Water decocts 20 minutes, merges juice, is filtered with liquid pass filter spare;
4)Step 3)Obtained filtrate is purified, and stands 2h, and filter again;
5)Step 3)Obtained filtrate is concentrated, and cocnentration factor is 1.041-1.125, in the liquid medicine after concentration water account for 50%~
51.1wt%, medicament account for 48.9~50wt%, then simple syrup mixing is added with the ratio of sugared content 68%, concentrated after to obtain the final product, use
In the drug of anti-aging.
9. drug is delaying to decline made from the drug described in claim 1-7 any one or the method using claim 8
Application in old drug or treatment senile disease drug.
10. application according to claim 9, it is characterised in that:Senile disease is Spleen-Qi Deficiency, insufficiency of the spleen-yang, kidney-yang deficiency, spleen
Kidney-yang deficiency, kidney-yin deficiency, the deficiency of liver-yin and kidney-yin, the insufficiency of heart and spleen, insufficiency of lung-QI,deficiency of lung-QI, lung-kidney deficiency is hypofunction of both the spleen and the lung, and god is tired caused by kidney essence deficiency
Body is weary, has a dizzy spell, soreness and weakness of waist and knees, aversion to cold and cold limbs, night pollakiuria or the heeltap not to the utmost, failure of memory, insomnia and dreamful sleep, alopecia or
Poliosis, easy catching a cold, micro- cough shortness of breath, anorexia, the aging phenomenon of sexual hypoesthesia.
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