CN103627604A - Health-care wine with function of tonifying kidney and preparation method thereof - Google Patents
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- CN103627604A CN103627604A CN201310645480.2A CN201310645480A CN103627604A CN 103627604 A CN103627604 A CN 103627604A CN 201310645480 A CN201310645480 A CN 201310645480A CN 103627604 A CN103627604 A CN 103627604A
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a health-care wine with a function of tonifying kidney and a preparation method thereof. The health-care wine is prepared by the following traditional Chinese medicinal materials soaked with a wine: kudzuvine roots, rhizoma polygonati, lalang grass rhizome, lycium barbarum L., red dates, peach kernel, poria cocos, polygonatum odoratum, Chinese yam, and fructus alpiniae oxyphyllae. The health-care wine has the functions of nourishing and tonifying kidney, invigorating spleen and supplementing qi, enhancing human body immunity, resisting fatigue, improving human body heart and cerebral vessels, and resisting aging.
Description
Technical field
The present invention relates to alcoholic drink field, be specifically related to a kind of kidney-nourishing health promoting wine and preparation method thereof.
Background technology
Along with the raising of modern society's living standards of the people, the enhancing of health care's consciousness, people also constantly increase the demand of healthcare product.While is along with the quickening of social life rhythm, the aggravation of people's life, operating pressure, there is the sub-health status that the different kidney deficiency syndrome of Traditional Chinese Medicine of degree is waited in some people particularly middle-aging male, as lusterless complexion, myasthenia of the limbs, pain in low back and legs, lassitude, the deficiency of qi in middle-jiao, insomnia and dreamful sleep, hyposexuality or sexual dysfunction etc.Kidney deficiency syndrome of Traditional Chinese Medicine and Kidney-supplementing establishing-Yang prescription are to face very wide, the far-reaching branch of utilization in the health care of demonstrate,proving application and people's daily life in traditional chinese medicine, and kidney deficiency syndrome of Traditional Chinese Medicine much face card performance ubiquitous some subhealth state syndrome of crowd suitable for modern society and subhealth state physique has homogeneity significantly, as related to tired class and the weak class physique of subhealth state in " international statistical classification of diseases and related health problems (ICD.10) ".
Kidney plays an important role with reproduction to growing of human body, is the basic of Whole Body negative and positive.Kidney yang is called as " Yuanyang ", " kidney-yang ", insufficiency of kidney-YANG, and whole body metabolism reduces, and each function reduces, and reproductive function is also influenced.It " sun " of Kidney-supplementing establishing-Yang is real be kidney yang this " Yuanyang ", is not the sexual function it " sun " of narrow sense, and sexual function it " sun " is to be included under the attribute of kidney yang this " Yuanyang ".Establishing-Yang is also for insufficiency of kidney-YANG and diagnosis and treatment based on an overall analysis of the illness and the patient's condition, solves " kidney yang " weak assertive evidence problem, and not more the recovery of narrow sense or sexual function improving executes and reuse the dry medicine of temperature with biased acts such as supporing yang, Wen Yang, Xing Yang, establishing-Yangs.The subhealth state colony that application traditional Chinese medicine and pharmacy health care's kidney invigorating and YANG supporting prescription prevented, improved suffer from a deficiency of the kidney physique or syndrome is a kind of useful selection, is also the concrete behave of developing motherland's medical treasure-house, by numerous doctors and enterprise, is put into practice.
Alcoholic strength temperature and taste is pungent, Wen Zheneng dispelling cold, Xin Zheneng disperses, so wine can dredge the channels, promoting the circulation of qi and blood, exempt from numbness dissipating bind, warming YANG to expel cold, can dispersing the stagnated live-QI to relieve the stagnation of QI, a surname's feelings freely anticipate.Again because wine is the elite that cereal is brewageed, therefore can also help stomach.< < natural science will > > carries: king is respectful, Zhang Heng, equal three people of horse emit mist row in morning.One people drinks, a human diet, and a people is on an empty stomach.Empty stomach person is dead, and full trencherman is sick, and alcohol user is strong.This shows, and " wine gesture is warded off evil, is better than and makes the effect of eating also." combination of wine and medicine is the much progress of health of drinking.In the successive dynasties medicine works of China, almost there is bar none medicinal liquor to control the record of disease body-building.Although the initial drinking behavior of the mankind can't be referred to as the health of drinking, and has close contacting with health care.Initial wine is that wild fruit that the mankind gather obtains suitable condition spontaneous fermentation and forms remaining time; because many wild fruits itself just have pharmaceutical use; so initial wine can deserve to be called natural " health promoting wine ", it has certain protection and promoter action to HUMAN HEALTH.Today is along with scientific and technical progress, from the basis of the traditional technology of Chinese medicine infusing drugs in wine, developed into modernization meanses such as utilizing extraction, lixiviate and biotechnology, extracts the functional medicinal-liquor that effective ingredient in Chinese medicine is made high-content.
Summary of the invention
The object of this invention is to provide a kind of kidney-nourishing health promoting wine;
Another object of the present invention is to provide a kind of preparation method of kidney-nourishing health promoting wine.
The object of the invention is to realize by following technical scheme:
Kidney-nourishing health promoting wine of the present invention is to be prepared from by the raw material that comprises following weight part:
Root of kudzu vine 25-35 part, sealwort 15-25 part, Rhizome of Lalang Grass 20-30 part, matrimony vine 10-20 part, red date 10-20 part, peach kernel 7-15 part, Poria cocos 15-25 part, radix polygonati officinalis 15-25 part, Chinese yam 15-25 part, Sharpleaf Galangal Fruit 7-15 part, 60-80% wine base 400-600 part.
Preferably, be that raw material by following weight part is prepared from:
30 parts of the roots of kudzu vine, 20 parts of sealworts, 25 parts of Rhizome of Lalang Grass, 15 parts of matrimony vines, 15 parts of red dates, 12 parts, peach kernel, 20 parts, Poria cocos, 20 parts of radix polygonati officinalis, 20 parts of Chinese yams, 10 parts of Sharpleaf Galangal Fruits, 500 parts, 70% wine base.
Below the crude drug source of kidney-nourishing health promoting wine of the present invention:
The root of kudzu vine is the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi or sweet kudzu Pueraria thomsonii Benth..Taste is sweet, pungent, cool in nature.Return spleen, stomach warp.The root of kudzu vine has relieving muscles diaphoresis, treating measles, and antipyretic promoting the production of body fluid, rises the effect of positive antidiarrheal.For fever caused by exogenous pathogens headache, Xiang Qiang, thirsty, measles without adequate eruption, have loose bowels, the disease such as hypertension neck pain.
The modern study root of kudzu vine contains more than 20 kind of isoflavones components, root of kudzu vine glucoside, triterpenes, alkaloid and other activeconstituentss, has multiple pharmacological effect.Total ketone in the root of kudzu vine can increase brain and volume of blood flow coronarius.The root of kudzu vine has obvious promoter action to the cerebral circulation of animal and human's body.
Sealwort is liliaceous plant Yunnan sealwort Polygonatum kingianum Coll. et Hemsl., sealwort Polygonatum sibiricum Red. or the David's-harp (dry rhizome of Polygonatum cyrtonema Hua..Taste is sweet, and property is flat.Return spleen; Lung; Kidney channel.Boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.Have hypotensive, hypoglycemic, reducing blood-fat, atherosclerosis, delays senility and antibacterially waits effect, polygonatum polysaccharide has Immunestimulatory effect.For lung-dryness syndrome due to deficiency of YIN, the few phlegm of dry cough, and the labor of the YIN-deficiency of the lung and kidney chronic cough etc. of coughing.For weakness of the spleen and the stomach.Both tonifying spleen-yin, beneficial temper again, for deficiency of kidney essence, obtain dizzy, soreness of the waist and knees, early whitening of beard and hair and quenching one's thirst etc.
Rhizome of Lalang Grass is the dry rhizome of grass cogongrass Imperata cylindrica Beauv. var. major (Nees) C. E. Hubb..Sweet, cold.Return lung, stomach, urinary bladder channel.Cool blood, hemostasis, heat-clearing, diuresis.Control pyreticosis polydipsia, spit blood, bleeding from five sense organs or subcutaneous tissue, lung heat is breathed heavily urgency, stomach energy hiccup, gonorrhoea, dysuria, oedema, jaundice.
Matrimony vine is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Taste is sweet, and property is flat.Return liver, kidney channel.Nourishing liver and kidney, replenishing vital essence to improve eyesight.For consumptive disease essence, lose, soreness of waist and knee joint, dizzy tinnitus, interior heat is quenched one's thirst, and the deficiency of blood is sallow, and blurred vision is not clear.The traditional Chinese medical science conventional it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, the illness such as seminal emission.The essential nutritive substance that wolfberry fruit contains the healthy eye such as abundant carotene, multivitamin and calcium, iron.Ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN cause looks thing duskization and nyctalopia, usually uses wolfberry fruit.
Modern pharmacology studies confirm that the adjustable body's immunity of wolfberry fruit, can effectively suppress tumor growth and cell mutation, have delay senility, the effect of the aspect such as anti-fatty liveranti-fatty liver, adjusting blood fat and blood sugar energy, and be applied to clinical.
Red date is the dry mature fruit of Rhamnaceae jujube jujube Ziziphus jujuba Mill. var. inermis (Bunge) Rehd..The nutritive ingredients such as red date rich in proteins, fat, carbohydrate, carotene, vitamin B group, vitamins C, vitamin P and calcium, phosphorus, iron and cyclic monophosphate.Wherein ascorbic content comes out at the top in fruit, has VITAMIN king's laudatory title.The cyclic monophosphate that red date is contained, is the essential composition of human body cell energy metabolism, can muscle strength reinforcing, Ginseng Extract, vasodilation, increase myocardial contraction, improve myocardial nutrition, to preventing and treating cardiovascular system diseases, there is good effect; Traditional Chinese medicine theory thinks, red date has the effects such as qi-restoratives benefit gas, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach, and red date has good therapeutic effect to illnesss such as chronic hepatitis, liver cirrhosis, anaemia, anaphylactoid purpuras; Red date contains triterpene compound and cyclic monophosphate, has stronger anticancer, anti-allergic effects.Date can moisten cardiopulmonary, cough-relieving, tonifying the five internal organs, it is deficient to control, except stomach addiction gas, in can also pacifying, support spleen, flat stomach Qi, logical nine orifices, help 12 through etc.
Modern study shows, red date has prevention transfusion reaction, reduces serum glutamic pyruvic transminase, antitumor, anti-oxidant, hypotensive, decreasing cholesterol, liver protecting, raising immunizing power, control cerebral blood supply insufficiency, antianaphylaxis, anti-angiocardiopathy, prevent and treat the effects such as osteoporosis and anaemia.
Peach kernel is the dry mature seed of rosaceous plant peach Prunus persica (L.) Batsch or mountain peach Prunus davidiana (Carr.) Franch..Bitter, sweet, flat.The thoughts of returning home, liver, large intestine channel.Energy promoting blood circulation to remove blood stasis, relaxes bowel, relieving cough and asthma.Containing amygdaloside, synaptase, volatile oil, fatty oil, in oil, mainly contain olein and a small amount of glyceryl linoleate.Peach kernel extracting solution can obviously increase cerebral blood flow (CBF), increases the volume of blood flow of dog femoral artery, reduces vascular resistance, improves hemodynamic situation.
Poria cocos is the dry sclerotia of On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf.Sweet, light, flat.The thoughts of returning home, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, the peaceful heart of invigorating the spleen.For oedema oliguria, phlegm and retained fluid is dizzy throbs with fear, and insufficiency of the spleen food is few, and have loose bowels in loose stool, confused and worried, palpitation with fear insomnia.Main component in Poria cocos is pachyman, and content is very high.Various bacteria is had to restraining effect; Can fall hydrochloric acid in gastric juice, digestive tract ulcer is had to preventive effect; Liver injury is had to significant protective effect; There is antineoplastic action; Can many-sided immunologic function be regulated; Can make oligoleukocythemia due to chemotherapy accelerate; And there is a calm effect.
Radix polygonati officinalis is the dry rhizome of liliaceous plant radix polygonati officinalis Polygonatum odoratum (Mill.) Druce.Taste is sweet, is slightly cold, and property is flat.Return lung; Stomach warp.Nourishing YIN to relieve dryness, promotes the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior heat is quenched one's thirst.
Chinese yam is the dry rhizome of Dioscoreaceae plant Chinese yam Dioscorea opposita Thumb..Sweet, flat.Return spleen, lung, kidney channel.Tonifying spleen nourishing the stomach, the beneficial lung that promotes the production of body fluid, the puckery essence of kidney tonifying.Few for insufficiency of the spleen food, chronic diarrhea, the deficiency syndrome of the lung is breathed with cough, emission due to deficiency of the kidney, under band, frequent micturition, abnormal heat is quenched one's thirst.
In Chinese yam, be rich in a large amount of protein, vitamin B group, vitamins C, vitamin-E, glucose, crude protein amino acid, bile alkaline, wallantoin etc., Human Lipid Metabolism can be prevented and treated abnormal, and arteriosclerosis, to safeguarding that Regular Insulin normal function also has certain effect, there is enhancing body immunity, benefit heart and tranquilizing mind, rather coughs Dingchuan, and the health-care effect such as delay senility.Wherein important nutritive ingredient Chinese yam soap is the precursor materials of synthetic estrogen, nourishing YIN and invigorating YANG, strengthens metabolic effect; And phlegmatic temperament of the polysaccharide protein composition containing in fresh tuber, zymigen etc. can be prevented cardiovascular fatty deposits, contribute to digestion and the absorption of stomach and intestine.
Sharpleaf Galangal Fruit is the dry mature fruit of zingiberaceous plant intelligence development Alpinia oxyphylla Miq..Taste is pungent, warm in nature.Enter the heart, spleen; Kidney channel.Temperature kidney controlling nocturnal emission with astringent drugs contracting urine, phlegm is taken the photograph in warm spleen appetizing.Cure mainly insufficiency of spleen-YANG; Vomiting; Have loose bowels; Cold educating in abdomen; The many salivas of mouth; Enuresis due to deficiency of the kidney; Frequent micturition; Seminal emission; Gonorrhoea, the diseases such as many salivas.Sharpleaf Galangal Fruit is containing volatile oil, Sharpleaf Galangal Fruit ketone, VITMAIN B1, Lin Suanna Vitamin B2 Sodium Phosphate, vitamins C, vitamin-E and multiple amino acids, lipid acid etc.Sharpleaf Galangal Fruit decoction has the effect of stomach invigorating, antidiuresis, minimizing salivation.Its water extract has the ascitogenous sarcoma of inhibition S180.The effect of cell enlargement.Its water extract and ethanol extraction have the effect that suppresses ileum contraction.In addition, its methanol extract has enhancing left atrium convergent force, suppresses the effects such as activity of exempting from aorta contraction and inhibition prostaglandin synthetase that Repone K causes.
Wine, warm in nature and taste is pungent, Wen Zheneng dispelling cold, Xin Zheneng disperses, so wine can dredge the channels, promoting the circulation of qi and blood, exempt from numbness dissipating bind, warming YANG to expel cold, can dispersing the stagnated live-QI to relieve the stagnation of QI, a surname's feelings freely anticipate.
Again because wine is the elite that cereal is brewageed, therefore can also help stomach.
Another aspect of the present invention has been to provide the preparation method of kidney-nourishing health promoting wine of the present invention:
(1) get whole 10 taste medicinal materials, clean, sterilizing, dry, chopping;
(2) medicinal material after chopping soaks 30-40 days with wine base;
(3) will soak gained medicated liquor and filter, obtain filtrate;
(4) filtrate adds water and rice wine is deployed into 800-1500 part, and wine degree is 25-45%;
(5) deployed medicated liquor filters after naturally clarifying;
(6) the wine liquid after filtration stores 7 days, obtains described health promoting wine.
The preparation method of kidney-nourishing health promoting wine of the present invention is preferably as follows:
(1) get whole 10 taste medicinal materials, clean, sterilizing, dry, chopping;
(2) medicinal material after chopping adds rock sugar and wine base to soak 35 days;
(3) will soak gained medicated liquor and filter, obtain filtrate;
(4) filtrate adds water and rice wine is deployed into 1000 parts, and wine degree is 32%;
(5) deployed medicated liquor filters after naturally clarifying;
(6) the wine liquid after filtration stores 7 days, obtains described health promoting wine.
Kidney is bases of internal organs, the root of 12 warps, and the congenital foundation is kidney.Suffer from a deficiency of the kidney how weak by plain body, or old deficiency of the kidney, or prolonged illness is impairment of the kidney, or the factor such as excess of sexual intercourse causes.The present invention adopts multiple kidney and spleen invigorating, the Chinese medicine of the strong body of invigorating blood circulation carries out reasonable preparation, and the various symptom effects that treating suffers from a deficiency of the kidney causes are remarkable.
In side, the root of kudzu vine rises sun, promotes brain and circulation of blood coronarius; The sealwort tonifying yin of fostering the spirit of nobility, tonifying speen and tonifying kidney; The main internal lesion caused by overexertion void of Rhizome of Lalang Grass is thin; Matrimony vine is controlled hepatic and renal YIN deficiency, improving eyesight, adjusting immunity of human body, anti-ageing; Red date tonifying the five internal organs, control deficient, blood-enriching tranquillizing, improve cardiovascular function; Peach kernel is improved effect to blood flow retardance, blood obstacle, can make each internal organs respectively organize functional recovery normal; The peaceful heart of Poria cocos invigorating the spleen, adjusting immunizing power; Radix polygonati officinalis nourishing YIN to relieve dryness; Chinese yam tonifying spleen kidney tonifying, strengthens body immunity, and beneficial heart and tranquilizing mind, delays senility; The stomach invigorating of Sharpleaf Galangal Fruit temperature kidney; Each taste soaks and can make activeconstituents in medicinal material produce good synergy with rice wine above.There is invigrating kidney, invigorating the spleen and benefiting QI, enhancing body immunity, antifatigue, improve human body cardio and vascular function, the anti-ageing function of waiting for a long time.
A kind of kidney-nourishing health promoting wine provided by the invention has following advantage:
1, kidney-nourishing health promoting wine provided by the invention can significantly raise kidney-yang deficiency model mouse temperature, increase its autonomic activities number and extend low temperature swimming time.
2, clinical observation shows, the symptoms such as kidney-nourishing health promoting wine of the present invention is cold to chilly, the limb due to insufficiency of kidney-YANG, soreness of the waist and knees, clear urine in large amounts, frequent urination at night have utmost point significant curative effect, efficient more than 94.8%; To cardinal symptom effects of being significantly improved such as impotence, premature ejaculation, seminal emissions, efficient more than 80%.The dizziness and tinnitus of middle-older patient, memory are weakened also to have and more than 48.1% have result for the treatment of.Clinical trial proves that kidney-nourishing health promoting wine of the present invention can effectively alleviate or disappearance insufficiency of kidney-YANG causes aversion to cold and cold limbs, soreness of the waist and knees are obvious, and enuresis nocturna improves the sexual dysfunctions such as impotence that insufficiency of kidney-YANG causes, seminal emission, premature ejaculation.
Embodiment
Below by embodiment, further illustrate the present invention.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.
embodiment 1
Root of kudzu vine 25kg, sealwort 15kg, Rhizome of Lalang Grass 20kg, matrimony vine 10kg, red date 10kg, peach kernel 7kg, Poria cocos 15kg, radix polygonati officinalis 15g, Chinese yam 15kg, Sharpleaf Galangal Fruit 7kg, rock sugar 40kg.Get whole 10 taste medicinal materials, clean, sterilizing, dry, chopping, with alcoholic strength, be that 60% wine base 400kg soaks 30 days, soak gained medicated liquor and filter, get that filtrate adds water and rice wine is deployed into 800kg, rectification degree is 25%, deployed medicated liquor is squeezed into work in-process cylinder, naturally after clarification, filters, and the wine liquid after filtration stores 5 days, obtain described health promoting wine, filling after check.
embodiment 2
Root of kudzu vine 30kg, sealwort 20kg, Rhizome of Lalang Grass 25kg, matrimony vine 15kg, red date 15kg, peach kernel 12kg, Poria cocos 20kg, radix polygonati officinalis 20g, Chinese yam 20kg, Sharpleaf Galangal Fruit 10kg.Get whole 10 taste medicinal materials, clean, sterilizing, dry, chopping, add rock sugar 40kg, with alcoholic strength, be 70% wine base 500kg immersion 35 days, soaking gained medicated liquor filters, get that filtrate adds water and rice wine is deployed into 1000kg, rectification degree is 32%, and deployed medicated liquor is squeezed into work in-process cylinder, naturally after clarification, filter, wine liquid after filtration stores 7 days, obtains described health promoting wine, filling after check.
embodiment 3
Root of kudzu vine 35kg, sealwort 25kg, Rhizome of Lalang Grass 30kg, matrimony vine 20kg, red date 20kg, peach kernel 15kg, Poria cocos 25kg, radix polygonati officinalis 25g, Chinese yam 25kg, Sharpleaf Galangal Fruit 15kg.Get whole 10 taste medicinal materials, selected, cleaning, sterilizing, dry, chopping, with alcoholic strength, be that 80% wine base 600kg soaks 40 days, soak gained medicated liquor and filter, get that filtrate adds water and rice wine is deployed into 1500kg, rectification degree is 45%, deployed medicated liquor is squeezed into work in-process cylinder, naturally after clarification, filters, and the wine liquid after filtration stores 10 days, obtain described health promoting wine, after check, carry out filling.
embodiment 4
Root of kudzu vine 25kg, sealwort 25kg, Rhizome of Lalang Grass 25kg, matrimony vine 10kg, red date 20kg, peach kernel 15kg, Poria cocos 15kg, radix polygonati officinalis 25g, Chinese yam 20kg, Sharpleaf Galangal Fruit 7kg.Get whole 10 taste medicinal materials, selected, cleaning, sterilizing, dry, chopping, add rock sugar 60kg, with alcoholic strength, is 80% wine base 450kg immersion 32 days, soaking gained medicated liquor filters, get that filtrate adds water and rice wine is deployed into 900kg, rectification degree is 28%, and deployed medicated liquor is squeezed into work in-process cylinder, naturally after clarification, filter, wine liquid after filtration stores 8 days, obtains described health promoting wine, filling after check.
embodiment 5
Root of kudzu vine 30kg, sealwort 20kg, Rhizome of Lalang Grass 25kg, matrimony vine 10kg, red date 10kg, peach kernel 7kg, Poria cocos 25kg, radix polygonati officinalis 25g, Chinese yam 10kg, Sharpleaf Galangal Fruit 10kg.Get whole 10 taste medicinal materials, selected, cleaning, sterilizing, dry, chopping, add rock sugar 50kg, with alcoholic strength, is 65% wine base 550kg immersion 37 days, soaking gained medicated liquor filters, get that filtrate adds water and rice wine is deployed into 900kg, rectification degree is 40%, and deployed medicated liquor is squeezed into work in-process cylinder, naturally after clarification, filter, wine liquid after filtration stores 6 days, obtains described health promoting wine, filling after check.
pharmacodynamics test
The impact of the present invention on YANG asthenia disease model mice due to hydrocortisone
1 experiment material
1.1 medicines and reagent
The embodiment of the present invention 2 health promoting wine, 32 °;
Hydrocortisone injection: 10mg:2mL, Nanning Pharmaceutical Engerprise (Group) Corp., Guangxi, lot number 01040011.
1.2 laboratory animal
Kunming mouse, male, body weight 20±2g, Guangxi traditional Chinese medicine university Experimental Animal Center provides.
1.3 instrument
1/10000 electronic balance (LIBROR AEU 1, Japanese Shimadzu); ZH-LUO/8D mouse autonomic activities registering instrument (Anhui Zheng Hua biological Instrument and equipments company limited).
2 experimental techniques
2.1 animal groupings
The Kunming kind male white mouse that 5O body weight is 20 ± 2g is divided into 5 groups at random, every group of 1O only:
Experimental example 1: embodiment 2 health promoting wine high dose group, 9.2g/kg/d;
Dosage group in experimental example 2: embodiment 2 health promoting wine, 5.6g/kg/d;
Experimental example 3: embodiment 2 health promoting wine low dose group, 2.8g/kg/d;
Yang deficiency syndrome model group: equal-volume distilled water;
Normal group: equal-volume distilled water;
The modeling of 2.2 syndrome of deficiency of kidney-YANG models
Except Normal group, all the other respectively organize equal intramuscular injection every day hydrocortisone 25mg/kg, continuous 7 days.
2.3 administration
Modeling starts gastric infusion simultaneously, by grouping, gives respectively corresponding medicine.
2.4 body weight
The Mouse Weight of administration group and the variation difference of model group and control group mice body weight after investigation modeling.First record the body weight of the first five group mouse of modeling, after last administration 1h, the body weight of mouse respectively organized in record again, and data are carried out to statistical procedures.
2.5 body temperature
A performance of yang deficiency syndrome is temperature decline, and mouse, after injection hydrocortisone, just there will be the symptom of temperature decline, after last administration 1h, records the body temperature of mouse, at this, measures mouse anus temperature, and data are carried out to statistical procedures.
2.6 autonomic activities
The autonomic activities of yang deficiency syndrome mouse can reduce, and utilizes mouse autonomic activities registering instrument, and the autonomic activities number to mouse in 5min carries out record, and data are carried out to statistical procedures.
2.7 low temperature swimming times
The decline of anti-fatigue ability is another performance of yang deficiency syndrome, at this, adopts low temperature swimming test to test the anti-fatigue ability of mouse.
The method of swimming test is: at 1/3 place of mouse tail, be the weight of its body weight 1O%, and depth of water 30cm, water temperature (25 ± 1) ℃, measures mouse from putting into water to the unable swimming time floating, and data are carried out to statistical procedures.
2.8 Data Processing in Experiment
Data acquisition use (
± s) represent experimental result, relatively adopt t check between group, P<0.05 is for there being statistical significance difference.
3 experimental results are in Table 1.
Table 1 respectively organize mouse temperature, body weight, autonomic activities, swimming time comparison (
± s, n=10)
Note: with the comparison of yang deficiency syndrome model group, * P < 0.05, * * P < 0.01.
Test shows: kidney-nourishing health promoting wine of the present invention can significantly raise kidney-yang deficiency model mouse temperature, increase its autonomic activities number and extend low temperature swimming time.Prompting, clinical use can effectively improve the various illnesss that insufficiency of kidney-YANG causes.
clinical trial
1 basic document
This group case is totally 83 examples, the male sex's 75 examples wherein, women's 8 examples.20 years old~68 years old age, with old patient Nian Weizhu in 40 years old~60 years old.Wherein, 20 years old~39 years old age person's 13 examples, 40 years old~49 years old person's 29 examples, 50 years old~59 years old person's 30 examples, 60 years old above person's 11 example, the shortest person of the course of disease 1 year, elder 4 years, generally at 1 year~l0.
2 cases are selected
Belong to the case of < < tcm syndrome standard > > syndrome of deficiency of kidney-YANG Case definition regulation, include this clinical trial scope in:
Primary symptom:
First group: spinal column shin knee crymodynia or cold, sexual disorder, impotence, involuntary emission, premature ejaculation, cold sperm is sterile;
Second group: fertility, aversion to cold and cold limbs, One's spirits are drooping, complexion white or dark.
Or see disease:
First group: orbit is dark, tinnitus is as cicada, dysacusis, and tendency to fall asleep, forgetful, hypophrenia, soreness of the waist and knees, lower limb are weak, talalgia; Man's cold sensation of the genitalia, lower abdominal contraction, seminal emission; Woman's Hypomenorrhea look light is rare clearly, and profuse leukorrhea is rare clearly; Cold and pain in the lower abdomen, night pollakiuria is long clearly, the enuresis, dysuria, women's head-ornaments limbs or anasarca, diarrhea before dawn etc.;
Second group: pale white complexion is simple and unadorned, spiritlessness and weakness, the empty susceptible of body, the low lazy speech of sound, tastelessness and no thirst or like hot drinks, four limbs are not warm, clear urine in large amounts, loose watery stool.
Or see tongue: there is indentation on the light fat limit of tongue, and tongue is fat pale purple, tongue is purple dark, white and slippery fur or greasy etc.;
Or see arteries and veins: feeble pulse, deep and weak pulse, deep-thready pulse, deep-slow pulse, deep-thready pulse and a little less than chi, faint pulse being about to disappear etc.
Case definition:
1) meet typical shower;
2) first group, second group each two symptoms of primary symptom, and see main tongue and master pulse person;
3) first group of symptom of primary symptom, second group of two symptom, and or see first group of symptom of disease, and see any tongue picture of assertive evidence and master pulse person;
4) second group of two symptom of primary symptom, and or see first group of three symptom of disease, and see any tongue picture of assertive evidence and pulse condition person;
5) first group of two symptom of primary symptom, in second group " aversion to cold and cold limbs ", and or see two symptoms in second group of disease, and see any tongue picture of assertive evidence and pulse condition person;
6) first group of symptom of primary symptom, in second group " aversion to cold and cold limbs ", and or see each two symptoms in first group, second group of disease, and see any tongue picture of assertive evidence and pulse condition person;
7) in second group of primary symptom " aversion to cold and cold limbs ", and or see three symptoms, second group of two symptom in first group of disease, and see any tongue picture of assertive evidence and pulse condition person.
3 methods of suiting the medicine to the illness
Take the embodiment of the present invention 2 kidney-nourishing health promoting wine, each 50ml, 1 time every night, two weeks is a course for the treatment of.
4 curative effect judging standards
Effective: the 2/3 above symptom person of being improved;
Take a turn for the better: the 1/3 above symptom person of being improved;
Invalid: symptom is without improvement. or symptom is improved individually, but improve symptom deficiency.
5 the results are shown in Table 2
Table 2 is taken rear efficacy result
Clinical effectiveness shows: the symptoms such as kidney-nourishing health promoting wine of the present invention is cold to chilly, the limb due to insufficiency of kidney-YANG, soreness of the waist and knees, clear urine in large amounts, frequent urination at night have utmost point significant curative effect, efficient more than 94.8%; To cardinal symptom effects of being significantly improved such as impotence, premature ejaculation, seminal emissions, efficient more than 80%.The dizziness and tinnitus of middle-older patient, memory are weakened also to have and more than 48.1% have result for the treatment of.Clinical trial proves that kidney-nourishing health promoting wine of the present invention can effectively alleviate or disappearance insufficiency of kidney-YANG causes aversion to cold and cold limbs, soreness of the waist and knees are obvious, and enuresis nocturna improves the sexual dysfunctions such as impotence that insufficiency of kidney-YANG causes, seminal emission, premature ejaculation.
Model case:
Case 1: patient women, 52 years old, peasant.Private prosecution: plain body is weak, with the passing of time disease, shows anasarca, the depression of pressing, pale complexion, waist knee crymodynia, hands and feet being not warm, spiritlessness and weakness, oliguria, tongue is light fat, white,slippery and moist fur, deep-slow pulse.Take the embodiment of the present invention 3 kidney-nourishing health promoting wine, 50ml every night, takes and swollenly after first quarter moon disappears most, and trick is warm, and the mental status is better.Continue to take after three courses for the treatment of, all diseases disappear, and are judged to recovery from illness
Case 2: the patient male sex, 32 years old.Private prosecution is passed out semen the several months, now feels dizzy tinnitus, dreaming often and waking easily, and pain in the back, aversion to cold and cold limbs, enuresis nocturna two, three times, not to the utmost, tongue is light for dribbling of urine, deep,thready and forceless pulse.Take the embodiment of the present invention 5 kidney-nourishing health promoting wine, 50ml, after taking more than the moon, does not pass out semen again every night, and all cards take a turn for the better.Continue to take after two courses for the treatment of, all diseases disappear, and are judged to recovery from illness.
Although, above used general explanation, embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (4)
1. a kidney-nourishing health promoting wine, it is characterized in that being prepared from by the raw material of following weight part: root of kudzu vine 25-35 part, sealwort 15-25 part, Rhizome of Lalang Grass 20-30 part, matrimony vine 10-20 part, red date 10-20 part, peach kernel 7-15 part, Poria cocos 15-25 part, radix polygonati officinalis 15-25 part, Chinese yam 15-25 part, Sharpleaf Galangal Fruit 7-15 part, 60-80% wine base 400-600 part.
2. kidney-nourishing health promoting wine as claimed in claim 1, it is characterized in that being prepared from by the raw material of following weight part: 30 parts of the roots of kudzu vine, 20 parts of sealworts, 25 parts of Rhizome of Lalang Grass, 15 parts of matrimony vines, 15 parts of red dates, 12 parts, peach kernel, 20 parts, Poria cocos, 20 parts of radix polygonati officinalis, 20 parts of Chinese yams, 10 parts of Sharpleaf Galangal Fruits, 500 parts, 70% wine base.
3. kidney-nourishing health promoting wine as claimed in claim 1 or 2, is characterized in that it is prepared from by the following method:
(1) get whole 10 taste medicinal materials, clean, sterilizing, dry, chopping;
(2) medicinal material after chopping soaks 30-40 days with wine base;
(3) will soak gained medicated liquor and filter, obtain filtrate;
(4) filtrate adds water and rice wine is deployed into 800-1500 part, and wine degree is 25-45%;
(5) deployed medicated liquor filters after naturally clarifying;
(6) the wine liquid after filtration stores 5-10 days, obtains described health promoting wine.
4. kidney-nourishing health promoting wine as claimed in claim 1 or 2, is characterized in that it is prepared from by the following method:
(1) get whole 10 taste medicinal materials, clean, sterilizing, dry, chopping;
(2) medicinal material after chopping adds rock sugar and wine base to soak 35 days;
(3) will soak gained medicated liquor and filter, obtain filtrate;
(4) filtrate adds water and rice wine is deployed into 1000 parts, and wine degree is 32%;
(5) deployed medicated liquor filters after naturally clarifying;
(6) the wine liquid after filtration stores 7 days, obtains described health promoting wine.
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