CN114425066A - Composition, medicine, food or health-care product for relieving physical fatigue and preparation method thereof - Google Patents
Composition, medicine, food or health-care product for relieving physical fatigue and preparation method thereof Download PDFInfo
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- CN114425066A CN114425066A CN202011179748.4A CN202011179748A CN114425066A CN 114425066 A CN114425066 A CN 114425066A CN 202011179748 A CN202011179748 A CN 202011179748A CN 114425066 A CN114425066 A CN 114425066A
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Abstract
The invention provides a composition, a medicine, a food or a health-care product for relieving physical fatigue and a preparation method thereof. The composition comprises the following components in parts by weight: 1-24 parts of common turnip, 1-12 parts of Chinese yam, 1-10 parts of tuckahoe, 1-10 parts of kudzu root, 0.5-4 parts of polygonatum and 0.25-2 parts of dried orange peel. Experiments show that the composition can inhibit the accumulation of lactic acid after exercise, slow down the accumulation of blood lactic acid, reduce the content of serum urea nitrogen, improve the reserve of glycogen, improve endurance capacity and relieve physical fatigue.
Description
Technical Field
The invention belongs to the technical field of medicines, foods or health-care products, and particularly relates to a composition for relieving physical fatigue, a medicine, a food or a health-care product and a preparation method thereof.
Background
With the increasing pace of modern life and the increasing work pressure, more and more people exhibit symptoms of tiredness, weakness, lack of energy, inattention, reduced physical strength and work ability, etc., which are caused by fatigue. Fatigue includes physical and mental fatigue, and can lead to decreased muscle strength and endurance, decreased motor skills, decreased physical and mental functions, and the like. Physical fatigue is also called physical fatigue because a large amount of metabolites are generated in the body during the process of lasting long-time and strong physical activity, such as lactic acid, carbon dioxide, serum urea nitrogen and other substances are accumulated in the body to stimulate the tissue cells and the nervous system of the human body, so that people feel fatigue. If the fatigue is not recovered in time after the occurrence of the fatigue for a long time, the body can be further damaged or overstrain, the chronic fatigue syndrome appears, the endocrine disturbance of the body is caused, the resistance is reduced, the health and the life quality of people are greatly influenced, and the health of human beings is seriously threatened. Therefore, fatigue has become a prominent problem in today's society.
According to the survey of the world health organization: the world is only 5% of truly healthy people, 20% of people with disease, and 75% of people in sub-health. Chronic fatigue syndrome is a special manifestation of sub-health state, and if people do not pay attention to the chronic fatigue syndrome, the chronic fatigue syndrome is gradually aggravated along with the increase of working strength, so that health crisis is caused, and finally, the chronic fatigue syndrome is converted into diseases. The sub-health people are suitable for taking some health care products for relieving physical fatigue, and the health recovery is facilitated. Therefore, health-preserving and health-care products for relieving and improving fatigue states are urgently needed in the market to improve the health and life level of people. In recent years, with the increasing health consciousness of consumers, products which have small side effect and health-care function on human bodies are developed from natural plants, especially from traditional edible resources and are easier to be recognized by people. Therefore, the development of a safe and directly edible product which is composed of traditional medicine and food homologous products or active ingredients derived from natural plants and can effectively relieve physical fatigue is of great significance.
Disclosure of Invention
The invention aims to provide a composition, a medicine, a food or a health-care product which has the effects of nourishing liver and kidney and tonifying internal organs and can effectively relieve physical fatigue and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme.
A composition with the functions of nourishing liver and kidney, tonifying viscera and effectively relieving physical fatigue comprises the following components in parts by weight: 1-24 parts of common turnip; 1-12 parts of Chinese yam; 1-10 parts of poria cocos; 1-10 parts of kudzu roots; 0.5-4 parts of polygonatum; 0.25-2 parts of dried orange peel.
Optionally, the composition comprises the following components in parts by weight: 3-20 parts of common turnip; 2-10 parts of Chinese yam; 1.5-8 parts of poria cocos; 1.5-8 parts of kudzu root; 0.6-3 parts of polygonatum; 0.3-1.5 parts of dried orange peel.
Optionally, the composition comprises the following components in parts by weight: 5-20 parts of common turnip; 3-10 parts of Chinese yam; 2-8 parts of poria cocos; 2-8 parts of kudzu roots; 0.8-3 parts of polygonatum; 0.4-1.5 parts of dried orange peel.
Optionally, the composition comprises the following components in parts by weight: 8-20 parts of common turnip; 4-10 parts of Chinese yam; 3-8 parts of poria cocos; 3-8 parts of kudzu roots; 1-3 parts of polygonatum; 0.5-1.5 parts of dried orange peel.
For example, the composition comprises the following components in parts by weight: 20 parts of common turnip; 10 parts of Chinese yam; 8 parts of poria cocos; 8 parts of kudzu roots; 3 parts of polygonatum; 1.5 parts of dried orange peel.
For example, the composition comprises the following components in parts by weight: 15 parts of common turnip; 8 parts of Chinese yam; 6 parts of poria cocos; 6 parts of kudzu roots; 2 parts of polygonatum; 1 part of dried orange peel.
For example, the composition comprises the following components in parts by weight: 12 parts of common turnip; 6 parts of Chinese yam; 4 parts of poria cocos; 4 parts of kudzu roots; 1 part of polygonatum; 0.5 part of dried orange peel.
The invention also provides a preparation method of the composition for relieving physical fatigue, which comprises the following steps: the components are subjected to impurity removal, cleaning, drying or frying, the formula amounts are respectively weighed and evenly mixed to obtain the composition. The invention has no special requirement on the mixing mode of the raw materials, and the mixing method known in the field can be used. The mixing mode can be selected as follows: mixing the above materials, grinding into powder or mixing the above materials, and steaming. For example, the mixed milling method is as follows: the components are mixed and then crushed into coarse powder, and then the coarse powder is crushed into superfine powder by a superfine crusher; wherein, the particle size of the coarse powder can be 40-60 meshes; the ultrafine powder may have a particle size of 200 meshes or more.
The invention also aims to provide application of the composition in preparing medicines, foods or health products for relieving physical fatigue.
The invention also aims to provide a medicine, food or health-care product for relieving physical fatigue, which is prepared by taking the composition as an effective component or a main effective component and pharmaceutically, food or health-care product acceptable auxiliary materials. The composition for relieving physical fatigue is prepared into medicines, foods or health-care products, is more suitable for being taken and carried by eaters, is convenient to eat for a long time, and achieves the effect of relieving physical fatigue.
Optionally, the dosage form of the medicine, food or health-care product for relieving physical fatigue comprises capsules, tablets, granules, powder, pills or oral liquid.
The auxiliary materials include but are not limited to maltodextrin, microcrystalline cellulose, xylitol, sorbitol, erythritol, strawberry fruit powder, stevioside and magnesium stearate.
The physical fatigue relieving tablet comprises the composition for relieving physical fatigue and auxiliary materials; wherein optionally, the dosage of xylitol, erythritol, sorbitol, microcrystalline cellulose, maltodextrin, strawberry fruit powder, magnesium stearate and stevioside is 30-150%, 40-200%, 50-250%, 5-40%, 10-40%, 5-20%, 2-5% and 0-0.5% of the weight of the composition for relieving physical fatigue.
The invention also provides a preparation method of the tablet for relieving physical fatigue, which comprises the following steps:
(1) preparation of the composition: 1-24 parts of common turnip root are respectively taken; 1-12 parts of Chinese yam; 1-10 parts of poria cocos; 1-10 parts of kudzu roots; 0.5-4 parts of polygonatum; 0.25-2 parts of dried orange peel, removing impurities, cleaning, placing in a drying oven, and drying at 50-70 ℃; mixing the dried raw materials, and firstly crushing into coarse powder; pulverizing into superfine powder with superfine pulverizer to obtain composition; wherein the granularity of the coarse powder is 40-60 meshes; the granularity of the superfine powder is more than 200 meshes;
(2) auxiliary material pretreatment: respectively crushing xylitol, erythritol and/or sorbitol by a high-speed multifunctional crusher, and sieving by a 80-mesh sieve; respectively sieving microcrystalline cellulose, maltodextrin, strawberry fruit powder and/or stevioside with 80 mesh sieve;
(3) granulating and tabletting: weighing one or more of the composition, the pretreated xylitol, erythritol, sorbitol, microcrystalline cellulose, maltodextrin, strawberry fruit powder and stevioside according to a ratio, fully and uniformly mixing, and granulating, drying and finishing to prepare a finished granule; adding magnesium stearate, mixing well, selecting a proper punch die for tabletting, and obtaining the physical fatigue relieving tablet.
Wherein, the granulating mode can be wet granulating. Specifically, the granulating, drying and finishing method comprises the following steps: adding 80-95% ethanol (percentage concentration) as wetting agent into the mixed materials, stirring continuously while adding to obtain suitable soft material (the hardness of the soft material is generally held by hand to form a mass, and the soft material is dispersed when pushed), and granulating the prepared soft material by passing through a 16-20 mesh screen; spreading the wet granules on a baking pan, placing in an oven, drying at 60 + -5 deg.C until the water content of the granules is not more than 5.0%, taking out, naturally cooling to room temperature, and grading with 16-20 mesh sieve to obtain the final granules.
The composition provided by the invention can increase the body energy source substance reserve by increasing the content of substances such as glycogen, cAMP and the like of the body, and provides a material basis for the large consumption of energy substances during fatigue; or by improving the levels of superoxide dismutase (SOD), Glutathione (GSH), etc., regulating the activity of Lactate Dehydrogenase (LDH), and reducing the contents of Malondialdehyde (MDA), Blood Urea Nitrogen (BUN), etc., thereby enhancing the oxidation resistance of the organism, scavenging free radicals, and reducing the accumulation of metabolites caused by fatigue; or has antifatigue effect by improving ultrastructure change of skeletal muscle cells caused by fatigue, abnormal function of nervous system, regulating immunity, etc. Wherein the content of the first and second substances,
the roots of the lilac daphne are herbaceous plants of Brassicaceae Brassica genus, also named as the lilac daphne roots and the rutabaga, and the Tibetan language is named as the Newma, which is a commonly used plant used as both medicine and food by residents in Tibetan and Xinjiang areas, and are recorded in ancient books Ben Cao gang mu, Taiping Shenghui Fang and Tibetan medical books mannan materia Medica, New Tibetan medicine and four medical classics, and the lilac daphne has sweet taste and warm property, enters stomach and liver meridians, and has the effects of strengthening stomach, helping digestion, removing dampness and detoxifying, benefiting viscera, dredging meridians, relieving epigastric distention and fullness, and the like.
The yam is a dry rhizome of dioscorea opposita of the family dioscoreaceae, is also called yam, dioscorea opposita and dioscorea opposita, is a traditional nourishing food material used as both medicine and food in China, is listed as the superior product in the Shen nong Ben Cao Jing, and records that the yam is capable of tonifying middle-jiao, invigorating qi, growing muscle … for long-term taking, improving hearing and eyesight, reducing weight, not hungry and prolonging life. The yam is light in taste, slightly sour and neutral in nature, has the functions of tonifying spleen, nourishing stomach, promoting the production of body fluid, benefiting lung, tonifying kidney, arresting seminal emission and the like, and belongs to the field of Chinese yam.
Poria is the dry sclerotium of Poria cocos (a fungus in Polyporaceae), is one of the Chinese medicines "four monarch eight delicacies", recorded in Shennong Ben Cao Jing (Shennong's herbal Jing), is listed as the top grade, has sweet and light taste, mild nature, and has the functions of invigorating spleen and stomach, calming heart and tranquilizing mind, inducing diuresis and excreting dampness, and the like, and enters heart, lung, spleen and kidney meridians. Poria contains chemical components such as polysaccharides, triterpenes, sterols, amino acids, and fatty acids, wherein triterpenes and polysaccharides are the main active components, and have effects of inducing diuresis for removing edema, regulating immunity, protecting liver, resisting tumor, and resisting oxidation.
The kudzu root is the dry root of the leguminous plant kudzu or kudzu vine, is recorded in Shennong Bencao Jing of the Han Dynasty of China, has the reputation of Asian ginseng, is sweet and pungent in taste and cool in nature, enters spleen, stomach and lung meridians, and has the effects of promoting the production of body fluid to quench thirst, relieving exterior syndrome to reduce fever, invigorating yang to promote eruption, clearing and activating the channels and collaterals, relieving alcoholism and the like.
Yu Zhu is the dried rhizome of Yu Zhu of Polygonatum of Liliaceae, named as Shen and Yu Shen, which was recorded in Shen nong Ben Cao Jing, listed as the top grade, has sweet and slightly cold flavor, enters lung and stomach meridians, and has the effects of nourishing yin, moistening lung, nourishing stomach and promoting fluid production. Modern researches show that the polygonatum contains rich amino acids, flavones, cardiac glycosides, proteins, polysaccharides, starch and other substances, and has the pharmacological effects of tonifying heart, reducing blood pressure, reducing blood sugar, reducing blood fat, resisting fatigue, delaying senility and the like.
The dried orange peel is dry mature peel of citrus reticulata blanco of Rutaceae and cultivated varieties thereof, is also called orange peel and Guangchenpi, is a natural medicine-food homologous product, has fragrant smell and warm property, enters spleen, stomach and lung channels, and has the effects of regulating qi, strengthening spleen, eliminating dampness and reducing phlegm.
Compared with the prior art, the invention has the beneficial effects that:
the composition is prepared by scientifically mixing highly safe medicinal and edible products, namely yuenkanin, Chinese yam, tuckahoe, kudzu root, polygonatum and dried orange peel, has the effects of tonifying liver, heart, spleen, lung and kidney, and relieving physical or mental fatigue, lassitude and other deficiency symptoms caused by deficiency of heart, lung, liver and kidney yin, has the effects of nourishing yin and tonifying viscera in accordance with the principle of deficiency and tonifying in the traditional Chinese medicine, accords with the food therapy advocated by the traditional Chinese medicine, namely, the loss of essence, qi, blood and body fluid is supplemented by directly edible natural plants or the traditional medicinal and edible product nutrition food therapy, and achieves the purposes of obviously improving the symptoms of fatigue crowds and eliminating fatigue. Experiments show that the composition can inhibit the accumulation of lactic acid after exercise, slow down the accumulation of blood lactic acid, reduce the content of serum urea nitrogen, improve the reserve of glycogen, improve endurance capacity and relieve physical fatigue. The composition has the advantages of simple preparation process, convenient use, no toxic or side effect and good practical application value.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Detailed Description
The following detailed description of the embodiments of the present invention will be given in conjunction with examples to better understand the aspects of the present invention and the advantages of its various aspects. However, the specific embodiments and examples described below are for illustrative purposes only and are not intended to limit the present invention.
The drug effect experiment part adopts the 'physical fatigue relieving function' in the 'health food inspection and evaluation technical specification' (2003 edition) issued by the ministry of health to study.
The components used in the invention, such as yuenkan, Chinese yam, tuckahoe, kudzu root, polygonatum and dried orange peel, are all commercially available traditional Chinese medicinal materials. It should be noted that, if the specific conditions are not specified, the procedures are carried out according to the conventional conditions or the conditions recommended by the manufacturer, and the raw materials or auxiliary materials used, and the reagents or equipment used are not specified by the manufacturer, and are conventional products commercially available. All percentages, ratios, proportions, or parts are by weight unless otherwise specified.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. In addition, any methods and materials similar or equivalent to those described herein can be used in the practice of the present invention.
The present invention will be described below with reference to specific examples. The values of the process conditions taken in the following examples are exemplary and ranges of values are provided as indicated in the foregoing summary, and reference may be made to conventional techniques for process parameters not specifically noted. The detection methods used in the following examples are all conventional in the industry.
Example 1
1. The physical fatigue relieving tablet produced by the formula is prepared from the following raw materials and auxiliary materials in parts by weight: 12 parts of common turnip; 6 parts of Chinese yam; 4 parts of poria cocos; 4 parts of kudzu roots; 1 part of polygonatum; 0.5 part of tangerine peel; 40 parts of xylitol; 10 parts of microcrystalline cellulose; 7.5 parts of maltodextrin; and 1 part of magnesium stearate.
2. The preparation method specifically comprises the following steps:
(1) preparation of the composition: respectively taking radix Genkwa, rhizoma Dioscoreae, Poria, radix Puerariae, rhizoma Polygonati Odorati, and pericarpium Citri Tangerinae, removing impurities, cleaning, placing in oven, and oven drying at 50-70 deg.C; mixing the dried raw materials according to the proportion, and firstly crushing the mixture into coarse powder (sieving the coarse powder by a 40-mesh sieve); pulverizing into superfine powder (200 mesh sieve) with superfine pulverizer to obtain composition;
(2) auxiliary material pretreatment: crushing xylitol by a high-speed multifunctional crusher, and sieving the crushed xylitol by a 80-mesh sieve; then sieving microcrystalline cellulose and maltodextrin with a 80-mesh sieve respectively;
(3) and (3) granulating: weighing the composition, xylitol, microcrystalline cellulose and maltodextrin according to the proportion, and fully and uniformly mixing; adding 95% ethanol as wetting agent, stirring while adding, making into suitable soft material (the softness of soft material is generally held by hand to form into mass, and pushed to disperse), and granulating with 20 mesh sieve; spreading the wet granules on a baking pan, placing in an oven, drying at 60 + -5 deg.C until the water content of the granules is not more than 5.0%, taking out, naturally cooling to room temperature, and grading with a 20 mesh sieve to obtain granules;
(4) tabletting: adding magnesium stearate as release agent into the whole granule, mixing to obtain total mixed granule, and tabletting with proper punch die to obtain tablet (tablet weight 0.25g, administration method is twice per day, 2 tablets per time) for relieving physical fatigue.
Example 2
1. The physical fatigue relieving tablet produced by the formula is prepared from the following raw materials and auxiliary materials in parts by weight: 15 parts of common turnip; 8 parts of Chinese yam; 6 parts of poria cocos; 6 parts of kudzu roots; 2 parts of polygonatum; 1 part of dried orange peel; 50 parts of erythritol; 10 parts of microcrystalline cellulose; 7.5 parts of strawberry fruit powder; and 1 part of magnesium stearate.
2. The preparation method specifically comprises the following steps:
(1) preparation of the composition: respectively taking radix Genkwa, rhizoma Dioscoreae, Poria, radix Puerariae, rhizoma Polygonati Odorati, and pericarpium Citri Tangerinae, removing impurities, cleaning, placing in oven, and oven drying at 50-70 deg.C; mixing the dried raw materials according to the proportion, and firstly crushing the mixture into coarse powder (sieving the coarse powder by a 40-mesh sieve); pulverizing into superfine powder (200 mesh sieve) with superfine pulverizer to obtain composition;
(2) auxiliary material pretreatment: crushing erythritol by a high-speed multifunctional crusher, and sieving by a 80-mesh sieve; then sieving microcrystalline cellulose and strawberry fruit powder with 80 mesh sieve respectively;
(3) and (3) granulating: respectively weighing the composition, erythritol, microcrystalline cellulose and strawberry fruit powder according to the proportion, and fully and uniformly mixing; adding 80% ethanol as wetting agent, stirring while adding, making into suitable soft material (the softness of soft material is generally held by hand to form into mass, and pushed to disperse), and granulating with 20 mesh screen; spreading the wet granules on a baking pan, placing in an oven, drying at 60 + -5 deg.C until the water content of the granules is not more than 5.0%, taking out, naturally cooling to room temperature, and grading with 16 mesh sieve to obtain granules;
(4) tabletting: adding magnesium stearate as release agent into the whole granule, mixing to obtain total mixed granule, and tabletting with proper punch die to obtain tablet (tablet weight 0.25g, administration method is twice per day, 2 tablets per time) for relieving physical fatigue.
Example 3
1. The physical fatigue relieving tablet produced by the formula is prepared from the following raw materials and auxiliary materials in parts by weight: 20 parts of common turnip; 10 parts of Chinese yam; 8 parts of poria cocos; 8 parts of kudzu roots; 3 parts of polygonatum; 1.5 parts of dried orange peel; 55 parts of sorbitol; 15 parts of microcrystalline cellulose; 10 parts of strawberry fruit powder; and 1 part of magnesium stearate.
2. The preparation method specifically comprises the following steps:
(1) preparation of the composition: respectively taking radix Genkwa, rhizoma Dioscoreae, Poria, radix Puerariae, rhizoma Polygonati Odorati, and pericarpium Citri Tangerinae, removing impurities, cleaning, placing in oven, and oven drying at 50-70 deg.C; mixing the dried raw materials according to the proportion, and firstly crushing the mixture into coarse powder (sieving the coarse powder by a 60-mesh sieve); pulverizing into superfine powder (200 mesh sieve) with superfine pulverizer to obtain composition;
(2) auxiliary material pretreatment: crushing sorbitol by a high-speed multifunctional crusher, and sieving by a 80-mesh sieve; then sieving microcrystalline cellulose and strawberry fruit powder with 80 mesh sieve respectively;
(3) and (3) granulating: weighing the composition, sorbitol, microcrystalline cellulose and strawberry fruit powder according to the proportion, and fully and uniformly mixing; adding 95% ethanol as wetting agent, stirring while adding, making into suitable soft material (the softness of soft material is generally held by hand to form into mass, and pushed to disperse), and granulating with 20 mesh screen; spreading the wet granules on a baking pan, placing in an oven, drying at 60 + -5 deg.C until the water content of the granules is not more than 5.0%, taking out, naturally cooling to room temperature, and grading with a 20 mesh sieve to obtain granules;
(4) tabletting: adding magnesium stearate as release agent into the whole granule, mixing to obtain total mixed granule, and tabletting with proper punch die to obtain tablet (tablet weight 0.25g, administration method is twice per day, 2 tablets per time) for relieving physical fatigue.
Comparative example 1
The comparative example provides a physical fatigue relieving tablet which is prepared from the following raw materials and auxiliary materials in parts by weight: 2 parts of common turnip; 10 parts of Chinese yam; 8 parts of poria cocos; 8 parts of kudzu roots; 3 parts of polygonatum; 1.5 parts of dried orange peel; 55 parts of sorbitol; 15 parts of microcrystalline cellulose; 10 parts of strawberry fruit powder; and 1 part of magnesium stearate.
Comparative example 2
The comparative example provides a physical fatigue relieving tablet which is prepared from the following raw materials and auxiliary materials in parts by weight: 10 parts of Chinese yam; 8 parts of poria cocos; 8 parts of kudzu roots; 3 parts of polygonatum; 1.5 parts of dried orange peel; 55 parts of sorbitol; 15 parts of microcrystalline cellulose; 10 parts of strawberry fruit powder; and 1 part of magnesium stearate.
The preparation method of the tablets for relieving physical fatigue in the comparative examples 1 to 2 is the same as that in the example 3, and the details are not repeated.
Example 4
The efficacy of the physical fatigue-relieving functional test of the invention is evaluated as follows.
1. Test materials
1.1 test subjects
And (3) mouse: kunming healthy male mice, body mass 19 + -4 g, SPF grade.
1.2 materials and reagents
0.50g, 0.33g and 0.17g (respectively equivalent to 0.19g, 0.13g and 0.07g of crude drugs) of the physical fatigue relieving tablet prepared in example 3 are respectively weighed, and distilled water is respectively added to 20mL and uniformly mixed to respectively design three dosage groups of 0.50g/Kg & BW, 0.33g/Kg & BW and 0.17g/Kg & BW (the dosages respectively correspond to 30 times, 20 times and 10 times of the recommended dosage of a human body), and the other blank control group (distilled water) is reserved.
0.33g of each physical fatigue-relieving tablet prepared in examples 1-3 and comparative examples 1-2 is weighed to 20mL, dissolved and mixed uniformly, and both are designed into a 0.33g/Kg & BW dosage group (the dosage is equal to 20 times of the recommended dosage of a human body), and the other blank control group (distilled water) is reserved.
0.9% physiological saline; a lactic acid assay kit; a urea nitrogen determination kit; glycogen determination reagent kit.
2. Test method
2.1 physical fatigue-relieving tablet prepared in example 3
After 80 mice are adaptively fed for 3 weeks, randomly dividing the mice into 2 test groups, wherein one test group is a negative weight swimming test, a serum urea test and a blood lactic acid test, and the other test group is a glycogen test; each group was divided into 4 groups by using 40 mice randomly, a blank control group (distilled water), a low dose group (0.17g/Kg · BW), a medium dose group (0.33g/Kg · BW), a high dose group (0.50g/Kg · BW), 10 mice each; each group is continuously irrigated with stomach for 30d at the dosage of 20mL/Kg & BW for 1 time/d; raising temperature is 18-22 ℃, humidity: 50 to 60 percent.
2.1.1 measurement of mouse body Mass
Weighing and recording the mass of each group of mice before first intragastric administration, weighing and recording the mass of each group of mice after last intragastric administration (one group of experiments needs to be before swimming), and calculating the mass increment of each group of mice.
2.1.2 weight bearing swimming test of mice
30min after the last intragastric administration, a 5% mass lead skin was loaded on the tail, the mouse was swim in a swimming box with water depth of 30cm and water temperature of 25 ℃, and the time from swimming to exhaustion of the mouse was recorded by a stopwatch. The mice were considered to be exhausted when their heads fell on the water surface for 10s and could not emerge.
2.1.3 measurement of mouse serum Urea Nitrogen (BUN) and Blood Lactic Acid (BLA)
The mice swim under load until exhaustion, after resting for 15min, the eyeballs are picked up for blood collection, and the contents of urea nitrogen (BUN) and Blood Lactic Acid (BLA) in the serum of the mice are measured by using corresponding measuring reagent boxes.
2.1.4 determination of hepatic glycogen in liver tissue of mice
30min after the last administration of the sample of example 3, the mice of the two experimental groups were sacrificed, the liver was dissected out and liver glycogen was measured as required by the kit.
2.2 physical fatigue-relieving tablets prepared in examples 1 to 3 and comparative examples 1 to 2
According to the test method of physical fatigue test for alleviating physical fatigue described in example 3 above, the mice given the physical fatigue-alleviating tablets of examples 1 to 3 and comparative examples 1 to 2 and distilled water (i.e., blank control group) were tested for swimming time under load, serum urea nitrogen and liver glycogen according to the test method of the above-described medium-dose group.
3. Test results
3.1 test results for the sample of example 3
3.1.1 Effect on mouse body weight
And recording the body mass of each group of mice before the first intragastric lavage and 30min after the last intragastric lavage, and counting the body mass increment of each group of mice during the intragastric lavage. The results are shown in Table 1.
TABLE 1 Effect of samples on mouse body Mass
It can be seen that each dose group of the example samples had no significant effect on the mouse body mass gain compared to the blank control group (P > 0.05).
3.1.2 Effect on mice exhaustive swimming time
The weight-bearing swimming time of each group of mice is recorded and counted. The results are shown in Table 2. The elongation is (swimming time of dose group-swimming time of blank control group)/swimming time of blank control group × 100%.
TABLE 2 exhaustion of samples against mouse loadInfluence of swimming time
Denotes P <0.01
It can be seen that the negative gravity swimming exhaustion time of the mice in the high and medium dose groups is obviously prolonged compared with the blank control group.
3.1.3 Effect on serum urinary Nitrogen after mice exercise
And (3) carrying out load swimming on each group of mice to exhaustion, taking blood from eyeballs after resting for 15min, and measuring and counting the content of urea nitrogen in the blood serum of each group of mice after movement. The results are shown in Table 3. Clearance ═ urea nitrogen content (placebo-dose urea nitrogen content)/placebo urea nitrogen content x 100%.
TABLE 3 Effect of samples on serum Urea Nitrogen after mouse exercise
Denotes P <0.01
Therefore, compared with a blank control group, the serum urea nitrogen content of the mice in the high and medium dose groups is obviously reduced. The samples of the examples are shown to have the effect of reducing urea production in fatigue mice.
3.1.4 Effect on blood lactate after exercise in mice
The weight-bearing swimming of each group of mice is exhausted, the eyeballs are picked after the mice are rested for 15min, and the blood content of the lactic acid in the blood serum of each group of mice after exercise is measured and counted. The results are shown in Table 4. Clearance ═ blood lactic acid content (blank-dose group) per blood lactic acid content of blank x 100%.
TABLE 4 shadow of sample on blood lactate after mouse exerciseSound box
Denotes P <0.05
Therefore, compared with a blank control group, the blood lactic acid content of the mice in the high and medium dose groups is obviously reduced. The samples of the examples are shown to inhibit the accumulation of lactic acid after exercise and slow down the accumulation of blood lactic acid.
3.1.5 Effect on hepatic glycogen content in mice
The mice are killed 30min after the samples of the examples are given for the last time, the liver is taken and rinsed by physiological saline, then the liver is sucked dry by filter paper, the liver is accurately weighed, and then the content of glycogen of each group of mice is measured and counted according to a kit method. The results are shown in Table 5. The increase rate is (glycogen content in dose group-glycogen content in blank control group)/glycogen content in blank control group x 100%.
TABLE 5 Effect of samples on mouse glycogen content
Denotes P <0.05, denotes P <0.01
As can be seen, compared with the blank control group, the glycogen content of the mice in the high and medium dose groups is obviously increased. The experiment shows that the sample can improve the hepatic glycogen storage quantity of the mouse, improve the endurance of the mouse and relieve physical fatigue.
3.2 test results of samples of examples 1 to 3 and comparative examples 1 to 2
TABLE 6 test results of samples of examples 1 to 3 and comparative examples 1 to 2
Denotes P <0.05, denotes P <0.01
It can be seen that, compared with the blank control group, the samples of the groups of examples 1, 2 and 3 have significant effects on the mouse weight-bearing power exhaustion swimming time, the mouse serum urea nitrogen content and the mouse hepatic glycogen content, and are superior to the group of comparative example 1.
It should be understood that the above examples are only for clearly illustrating the present invention and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications of the invention may be made without departing from the scope of the invention.
Claims (10)
1. The composition for relieving physical fatigue is characterized by comprising the following components in parts by weight: 1-24 parts of common turnip, 1-12 parts of Chinese yam, 1-10 parts of tuckahoe, 1-10 parts of kudzu root, 0.5-4 parts of polygonatum and 0.25-2 parts of dried orange peel.
2. The composition according to claim 1, characterized by comprising the following components in parts by weight: 3-20 parts of common turnip, 2-10 parts of Chinese yam, 1.5-8 parts of tuckahoe, 1.5-8 parts of kudzu root, 0.6-3 parts of polygonatum and 0.3-1.5 parts of dried orange peel; 5-20 parts of common turnip, 3-10 parts of Chinese yam, 2-8 parts of tuckahoe, 2-8 parts of kudzu root, 0.8-3 parts of polygonatum and 0.4-1.5 parts of dried orange peel; or 8-20 parts of common turnip, 4-10 parts of Chinese yam, 3-8 parts of tuckahoe, 3-8 parts of kudzuvine root, 1-3 parts of fragrant solomonseal rhizome and 0.5-1.5 parts of tangerine peel.
3. The composition according to claim 1, characterized by comprising the following components in parts by weight: 20 parts of common turnip, 10 parts of Chinese yam, 8 parts of poria cocos, 8 parts of kudzu root, 3 parts of polygonatum odoratum and 1.5 parts of dried orange peel; 15 parts of common turnip, 8 parts of Chinese yam, 6 parts of poria cocos, 6 parts of kudzu root, 2 parts of polygonatum odoratum and 1 part of dried orange peel; or 12 parts of common turnip, 6 parts of Chinese yam, 4 parts of tuckahoe, 4 parts of kudzu root, 1 part of polygonatum and 0.5 part of dried orange peel.
4. Use of the composition of any one of claims 1 to 3 for the preparation of a medicament, food or health product for relieving physical fatigue.
5. A pharmaceutical, food or health product for relieving physical fatigue, which is characterized by comprising the composition of any one of claims 1 to 3 and pharmaceutically, food or health product acceptable auxiliary materials.
6. The drug, food or health product of claim 5, wherein the excipient comprises maltodextrin, microcrystalline cellulose, xylitol, sorbitol, erythritol, strawberry fruit powder, stevioside, magnesium stearate.
7. The pharmaceutical, food or health product of claim 6,
the dosage of the xylitol is 30-150% of the weight of the composition;
the using amount of the erythritol is 40-200% of the weight of the composition;
the sorbitol is used in an amount of 50-250% by weight of the composition;
the dosage of the microcrystalline cellulose is 5-40% of the weight of the composition;
the amount of the maltodextrin is 10-40% of the weight of the composition;
the dosage of the strawberry fruit powder is 5-20% of the weight of the composition;
the amount of the magnesium stearate is 2-5% of the weight of the composition;
the steviol glycoside is present in an amount of 0 to 0.5% by weight of the composition.
8. The drug, food or health product of claim 6, wherein the drug, food or health product is in the form of capsule, tablet, granule, powder, pill or oral liquid.
9. The preparation method of the physical fatigue relieving tablet is characterized by comprising the following steps:
preparation of the composition: mixing 1-24 parts of common turnip; 1-12 parts of Chinese yam; 1-10 parts of poria cocos; 1-10 parts of kudzu roots; 0.5-4 parts of polygonatum; 0.25-2 parts of dried orange peel, which is firstly crushed into coarse powder; pulverizing into superfine powder to obtain composition, wherein the particle size of the coarse powder is 40-60 mesh; the granularity of the superfine powder is more than 200 meshes;
auxiliary material pretreatment: pretreating auxiliary material raw materials to obtain an auxiliary material with the granularity of more than 80 meshes, wherein the auxiliary material raw materials comprise maltodextrin, microcrystalline cellulose, xylitol, sorbitol, erythritol, strawberry fruit powder and stevioside;
and (3) granulating: mixing the composition and the auxiliary materials, and granulating, drying and finishing to prepare a finished granule;
tabletting: and adding magnesium stearate into the whole granular material, uniformly mixing, and tabletting to obtain the physical fatigue relieving tablet.
10. The method of claim 9, wherein the granulating, drying and finishing process comprises: adding 80-95% ethanol into the uniformly mixed composition and the auxiliary materials to prepare a proper soft material, and sieving the soft material with a 16-20 mesh sieve to prepare wet granules; drying the wet granules at 60 +/-5 ℃ until the moisture content of the granules is not more than 5.0 percent, naturally cooling to room temperature, and finishing the granules by using a 16-20-mesh sieve to obtain finished granules.
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