CN105343808A - Traditional Chinese medicine composition with weight reducing effect and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition with weight reducing effect and preparation method of traditional Chinese medicine composition Download PDF

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CN105343808A
CN105343808A CN201510966269.XA CN201510966269A CN105343808A CN 105343808 A CN105343808 A CN 105343808A CN 201510966269 A CN201510966269 A CN 201510966269A CN 105343808 A CN105343808 A CN 105343808A
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樊利平
关美玲
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
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    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger

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Abstract

The invention belongs to the technical field of traditional Chinese medicines and discloses traditional Chinese medicine composition with a weight reducing effect and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicines in parts by weight as follows: 10-20 parts of vitex, 12-20 parts of oriental waterplantain rhizomes, 10-20 parts of lotus leaves, 8-22 parts of turmeric root tuber, 8-14 parts of officinal magnolia bark, 8-12 parts of poria cocos, 6-12 parts of Chinese angelica, 6-16 parts of endothelium corneum gigeriae galli, 10-12 parts of hawthorn fruits, 8-12 parts of peach kernels, 6-12 parts of dried tangerine peels and 2-10 parts of liquorice. Natural traditional Chinese medicines are adopted, and the traditional Chinese medicine composition adopts simple components and reasonable proportion, has low toxic and side effects, is convenient to use, has the efficacy of clearing summer-heat, loosening bowel to relieve constipation, removing stagnation, relieving distention, promoting digestion, invigorating the stomach and the like and can safely and effectively treat obesity.

Description

A kind of Chinese medicine composition with fat-reducing effect and preparation method thereof
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition with fat-reducing effect and preparation method thereof.
Background technology
Obesity is one group of common, ancient metabolism disease group.When human body feed heat is more than consumption of calorie, waste heat is with storage as fat in body, and its amount exceedes normal physiological requirement, then develops into obesity when reaching certain value.Its cause of disease mainly contains endogenous cause of ill and exopathogenic factor, and exopathogenic factor is Lack of Movement based on hyperphagia.Energy intake, more than heat exhaustion, makes lipogenesis increase be fat material base, and it is fat that endogenous cause of ill is that human body intrinsic factor make fat metabolic disturbance cause fat.Generally speaking, the Excess free enthalpy of energy is greater than consumption is the fat origin cause of formation.Obesity can cause various diseases, and as hypertension, coronary heart diseases and angina pectoris, cerebrovascular disease, diabetes, hyperlipemia, hyperuricemia, female irregular menstruation etc., can also increase the prevalence of malignant tumor.
The method for the treatment of of obesity conventional at present has behavior therapy, diet control, surgical intervention and Drug therapy, its drug treatment is main mainly with Western medicine, common Western medicine mainly contains two classes: a kind of is the appetite suppressant acting on maincenter, also known as anorexic medicine, it is the activity by the mediator that affects the nerves, and reduces 5-hydroxy tryptamine and norepinephrine reuptake, thus reduces food intake dose, appetite-suppressing and raising basal metabolic rate carry out loss of weight, as sibutramine; Another kind is the lipase inhibitor acting on periphery, and the absorption namely by blocking partial fat in diet reaches fat-reducing object, as orlistat.But both there is obvious untoward reaction, limit these medicines for long term maintenance therapy.According to the organic conception of theory of Chinese medical science, analyze the fat main function dirty with kidney,spleen,liver three from the differentiation of disease according to pathological changes of the viscera and their relevant.Conditioning viscera can be reached by Chinese medicine reasonable compatibility, make the functional rehabilitation of liver,spleen,kidney normal, by regulating dietary structure, preventing extraneous fat intake surplus, improving health environment, allow health itself possess the ability consuming superabundant fats, this is only the fundamental way for the treatment of of obesity.
Chinese invention patent application 201410007923.X relates to a kind of Chinese medicine composition for the treatment of of obesity, and this Chinese medicine composition comprises following raw materials: Poria, the Rhizoma Pinelliae, Rhizoma Atractylodis, Rhizoma Cyperi, Pericarpium Citri Reticulatae, Massa Medicata Fermentata, Rhizoma Chuanxiong and Semen Pharbitidis.Rapid-action to the treatment of obesity, side effect is little, but obesity itself is only considered in medication, and do not fully take into account the association disease of obesity, such as hypertension, hyperlipidemia etc., therefore not easily eradicate disease.
Summary of the invention
The association diseases such as hypertension, hyperlipidemia, hyperglycemia should be fully taken into account while treatment of obesity.Therefore.Object of the present invention is comprehensive medication, and fully take into account the association disease of obesity, Coryza Treated by Syndrome Differentiation, As the medicine took effect, the symptoms lessened.
For realizing object of the present invention, technical solution of the present invention is as follows:
The prescription of Chinese medicine composition of the present invention is formed by the Chinese drug preparation of following weight parts:
6-16 part, Fructus Crataegi 10-12 part, Semen Persicae 8-12 part, Pericarpium Citri Reticulatae 6-12 part and Radix Glycyrrhizae 2-10 part in Herba Viticis Cannabifoliae 10-20 part, Rhizoma Alismatis 12-20 part, Folium Nelumbinis 10-20 part, Radix Curcumae 8-22 part, Cortex Magnoliae Officinalis 8-14 part, Poria 8-12 part, Radix Angelicae Sinensis 6-12 part, chicken gold.
In the scope of this weight portion, the comparatively significant formula of preferred 3 curative effects:
Formula 1: in Herba Viticis Cannabifoliae 10 parts, Rhizoma Alismatis 12 parts, 10 parts, Folium Nelumbinis, Radix Curcumae 8 parts, Cortex Magnoliae Officinalis 8 parts, 8 parts, Poria, Radix Angelicae Sinensis 6 parts, chicken gold 6 parts, Fructus Crataegi 10 parts, 8 parts, Semen Persicae, Pericarpium Citri Reticulatae 6 parts and 2 parts, Radix Glycyrrhizae.
Formula 2: in Herba Viticis Cannabifoliae 20 parts, Rhizoma Alismatis 20 parts, 20 parts, Folium Nelumbinis, Radix Curcumae 22 parts, Cortex Magnoliae Officinalis 14 parts, 12 parts, Poria, Radix Angelicae Sinensis 12 parts, chicken gold 16 parts, Fructus Crataegi 12 parts, 12 parts, Semen Persicae, Pericarpium Citri Reticulatae 12 parts and 10 parts, Radix Glycyrrhizae.
Formula 3: in Herba Viticis Cannabifoliae 15 parts, Rhizoma Alismatis 16 parts, 14 parts, Folium Nelumbinis, Radix Curcumae 14 parts, Cortex Magnoliae Officinalis 10 parts, 10 parts, Poria, Radix Angelicae Sinensis 10 parts, chicken gold 12 parts, Fructus Crataegi 10 parts, 10 parts, Semen Persicae, Pericarpium Citri Reticulatae 8 parts and 6 parts, Radix Glycyrrhizae.
Correspondingly, the present invention also provides the preparation method of described Chinese medicine composition, comprises the following steps:
Step 1: get Herba Viticis Cannabifoliae and wash away impurity, crushed after being dried, crosses 60-80 mesh sieve, obtains coarse powder, coarse powder is placed in supercritical carbon dioxide extraction apparatus, the 30-45% volume fraction adding coarse powder weight is the ethanol of 60-85%, and regulation and control carbon dioxide flow is 15 ~ 20L/h, and extracting pressure is 15 ~ 20MPa, extraction temperature is 40 ~ 60 DEG C, extraction time is 1.5 ~ 2h, and decompression separation obtains Herba Viticis Cannabifoliae extract, retains Herba Viticis Cannabifoliae residue;
Step 2: take Rhizoma Alismatis, Radix Curcumae, Cortex Magnoliae Officinalis, Poria and Radix Angelicae Sinensis respectively in proportion, pulverize after cleaning, drying, merge coarse powder, add Herba Viticis Cannabifoliae residue, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, and microwave power is 400-600W, Extracting temperature is 40-60 DEG C, filter and retain filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract A;
Step 3: take Folium Nelumbinis in proportion respectively, in chicken gold, Fructus Crataegi, Semen Persicae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, pulverize after cleaning, drying, merge coarse powder, and merge with the filtering residue of step 2, add the water of medical material gross weight 8-12 times amount, reflux, extract, 2-3 time, each 3-6 hour, filter, merging filtrate, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract B;
Step 4: merge Herba Viticis Cannabifoliae extract, extract A and extract B, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.
Source, the nature and flavor of Chinese prescription of the present invention Chinese crude drug used, return through and effect:
Herba Viticis Cannabifoliae: this product is Verenaceae deciduous plant Herba Viticis Cannabifoliae dried leaves; Bitter in the mouth, property is put down; Return lung meridian; To induce sweat removing dampness, eliminating phlegm and relieving asthma; Removing toxic substances, expelling pathogenic wind from the body surface, dehumidifying, parasite killing, pain relieving.
Rhizoma Alismatis: this product is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis; Sweet in the mouth, cold in nature; Return kidney, urinary bladder channel; Diuresis, clearing away damp-heat.
Folium Nelumbinis: this product is the dried leaves of nymphaeaceae plant lotus; Bitter in the mouth, property is put down; Return liver, spleen, stomach warp; Clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis.
Radix Curcumae: this product is the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae; Acrid in the mouth, hardship, cold in nature; Return liver, the heart, lung meridian; Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.
Cortex Magnoliae Officinalis: this product is the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils., root bark and branch skin; Bitter in the mouth, pungent, warm in nature; Return spleen, stomach, lung, large intestine channel; Dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.
Poria: this product is the dry sclerotia of On Polyporaceae Poria; Sweet in the mouth, light, property is put down; GUIXIN, lung, spleen, kidney channel; Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica; Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
In chicken gold: this product is the dry inner wall of sandbag of Phasianidae animal man chicken; Sweet in the mouth, property is put down; Return spleen, stomach, small intestinal, urinary bladder channel; Invigorating the stomach and promoting digestion, arresting seminal emission.
Fructus Crataegi: this product is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi; Sour in the mouth, sweet, slightly warm in nature; Return spleen, stomach, Liver Channel; Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.
Semen Persicae: this product is the dry mature seed of rosaceous plant Fructus Persicae or Prunus davidiana; Bitter in the mouth, sweet, property is put down; GUIXIN, liver, large intestine channel; Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.
Pericarpium Citri Reticulatae: this product is the dry mature skin of rutaceae orange and variety thereof; Bitter in the mouth, pungent, warm in nature; Return lung, spleen channel; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The compatibility analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention with Rhizoma Alismatis and Folium Nelumbinis for monarch drug, clearing away summer-heat, diuresis, clearing away damp-heat; With in Herba Viticis Cannabifoliae, Radix Curcumae, Cortex Magnoliae Officinalis, chicken gold and Fructus Crataegi for ministerial drug, regulating qi to disperse stagnation, the therapeutic method to keep the adverse QI flowing downwards are except full, invigorating the stomach and promoting digestion, circulation of qi promoting dissipating blood stasis; With Poria, Radix Angelicae Sinensis, Semen Persicae and Pericarpium Citri Reticulatae for adjuvant drug, loosening bowel to relieve constipation, the stagnant relieving distension of row, regulating qi-flowing for strengthening spleen, regulating the flow of QI to ease the stomach; With Radix Glycyrrhizae for making medicine, the coordinating the actions of various ingredients in a prescription property of medicine, all medicines coordinate, and complement each other, synergism, have the effect such as clearing away summer-heat, loosening bowel to relieve constipation, row stagnant relieving distension, promoting digestion and invigorating the stomach, have very significant curative effect to obesity.
Compared with prior art, beneficial effect of the present invention is summarized as follows:
(1) Chinese medicine composition of the present invention has good fat-reducing effect, can clearing away summer-heat, loosening bowel to relieve constipation, row stagnant relieving distension, promoting digestion and invigorating the stomach.Animal data shows, Chinese medicine composition of the present invention can effectively reduce triglyceride, cholesterol and blood glucose, suppresses body weight to increase; Clinical data shows, Chinese medicine composition of the present invention has good curative effect to obese patient.
(2) Chinese medicine composition prescription reasonable ， Fill of the present invention and oiliness, disappears and does not just hinder, mild in medicine property and, compatibility rigorous ， Xiao Fill is double to be executed.In a word, it is low that Chinese medicine composition of the present invention is used for the treatment of obesity cost, and preparation method is simple, safe and effective, and toxic and side effects is little, stable curative effect, definite.
Detailed description of the invention
Below will the present invention is described further by specific embodiment, it will be understood by those skilled in the art that the present invention also can make other similar changes and obtains similar result and do not depart from content of the present invention and scope except following examples.
embodiment 1
The embodiment of the present invention 1 Chinese medicine composition is formed by the Chinese drug preparation of following weight portion:
In Herba Viticis Cannabifoliae 10 parts, Rhizoma Alismatis 12 parts, 10 parts, Folium Nelumbinis, Radix Curcumae 8 parts, Cortex Magnoliae Officinalis 8 parts, 8 parts, Poria, Radix Angelicae Sinensis 6 parts, chicken gold 6 parts, Fructus Crataegi 10 parts, 8 parts, Semen Persicae, Pericarpium Citri Reticulatae 6 parts and 2 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Step 1: get Herba Viticis Cannabifoliae and wash away impurity, crushed after being dried, crosses 60 mesh sieves, obtains coarse powder, coarse powder is placed in supercritical carbon dioxide extraction apparatus, 45% volume fraction adding coarse powder weight is the ethanol of 75%, and regulation and control carbon dioxide flow is 15L/h, and extracting pressure is 15MPa, extraction temperature is 50 DEG C, extraction time is 2h, and decompression separation obtains Herba Viticis Cannabifoliae extract, retains Herba Viticis Cannabifoliae residue;
Step 2: take Rhizoma Alismatis, Radix Curcumae, Cortex Magnoliae Officinalis, Poria and Radix Angelicae Sinensis respectively in proportion, pulverize after cleaning, drying, merge coarse powder, add Herba Viticis Cannabifoliae residue, adding medical material gross weight 8 times amount volume fraction is the ethanol of 70%, microwave extraction 12 minutes, and microwave power is 500W, Extracting temperature is 50 DEG C, filter and retain filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtained extract A;
Step 3: take Folium Nelumbinis in proportion respectively, in chicken gold, Fructus Crataegi, Semen Persicae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, pulverize after cleaning, drying, merge coarse powder, and merge with the filtering residue of step 2, add the water of medical material gross weight 8 times amount, reflux, extract, 3 times, each 5 hours, filter, merging filtrate, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtained extract B;
Step 4: merge Herba Viticis Cannabifoliae extract, extract A and extract B, drying under reduced pressure, pulverizes, and crosses 80 mesh sieves, obtains traditional Chinese medicine fine powder;
Step 5: add suitable adjuvant toward above-mentioned traditional Chinese medicine fine powder, make tablet with modern times conventional process of Chinese medicine preparation.
embodiment 2
The embodiment of the present invention 2 Chinese medicine composition is formed by the Chinese drug preparation of following weight portion:
In Herba Viticis Cannabifoliae 20 parts, Rhizoma Alismatis 20 parts, 20 parts, Folium Nelumbinis, Radix Curcumae 22 parts, Cortex Magnoliae Officinalis 14 parts, 12 parts, Poria, Radix Angelicae Sinensis 12 parts, chicken gold 16 parts, Fructus Crataegi 12 parts, 12 parts, Semen Persicae, Pericarpium Citri Reticulatae 12 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
embodiment 3
The embodiment of the present invention 3 Chinese medicine composition is formed by the Chinese drug preparation of following weight portion:
In Herba Viticis Cannabifoliae 15 parts, Rhizoma Alismatis 16 parts, 14 parts, Folium Nelumbinis, Radix Curcumae 14 parts, Cortex Magnoliae Officinalis 10 parts, 10 parts, Poria, Radix Angelicae Sinensis 10 parts, chicken gold 12 parts, Fructus Crataegi 10 parts, 10 parts, Semen Persicae, Pericarpium Citri Reticulatae 8 parts and 6 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 2.
pharmacodynamic study:
test example one: Chinese medicine composition of the present invention is to the influence research of Obesity of Rats disease
1, experimental technique
Getting 72 body weight is 80-100gSPF level SD rat, 6-8 week age, wherein 60 give the feedstuff of the self-control containing higher fatty acid high heat, give standard animal feedstuff, be set to Normal group under other 12 equal conditions.All rats all freely drink water, take food, and measure on every Mondays and record body weight.After 14 weeks, give body weight in the rat of high energy feed and exceed and give 120% of standard animal feedstuff rat average weight, then reach obesity standard, high fat diet obese model is successfully established.
The high fat diet obese model Mus 60 established is divided into 5 groups at random, often organizes 12, be respectively the basic, normal, high dosage group of Chinese medicinal tablet, positive controls and model group that the embodiment of the present invention 1 is obtained.The given low of basic, normal, high dosage group is respectively: 1g/Kg, 2g/Kg, 4g/Kg, positive controls gavage to 4g/Kg orlistat (Zhongmei Huadong Pharmaceutical Co., Ltd. Hangzhou), every day gavage 2 times, continuous use 30 days; Model group and Normal group all adopt the process of isometric(al) normal saline, and administering mode is with administration group.Rat, after 30 days, breaks end with special chopper rapidly by medication, and every rat extracting blood 2ml adds in the centrifuge tube having added 40U heparin in advance, 4 DEG C, centrifugal 20 minutes of 3000r.p.m rotating speed, gets supernatant and measures plasma cholesterol, triglyceride and blood sugar concentration.Collection of specimens, at duration of test, is weighed in weekly once.During administration, each group mice all gives standard animal feedstuff.
2, date processing
Data all adopt mean ± standard deviation to represent, adopt SPSS19.0 statistical software to carry out variance analysis, p< 0.05 is for there being significant difference; p< 0.01 is for there being pole significant difference.
3, experimental result
Table 1 respectively organizes rat body weight, cholesterol, triglyceride and blood sugar level
Note: "+" represents weightening finish; "-" represents loss of weight; Compare with Normal group, △ △ p< 0.01, △ △ △ p< 0.001; Compare with model group, * p< 0.05, * p< 0.01, * * p< 0.001; Compare with positive controls, # p< 0.05, ## p< 0.01.
From upper table 1, compare with Normal group, the body weight of model group rats, cholesterol, triglyceride and blood sugar level extremely significantly increase ( p< 0.01), illustrate that high fat diet obese model successfully constructs.After administration, the rat body weight of the high, medium and low dosage group of Chinese medicinal tablet that the embodiment of the present invention 1 of the present invention is obtained and positive controls alleviates all greatly, respectively organizes the cholesterol of rat, triglyceride with blood sugar level compared with model group, significantly reduction ( p< 0.05), wherein Chinese medicinal tablet high dose group therapeutic effect of the present invention be significantly better than positive controls ( p< 0.05 or p< 0.01).It can thus be appreciated that three dosage groups of Chinese medicinal tablet of the present invention all can significantly reduce rat body weight, cholesterol, triglyceride and blood sugar level, have the effect of good treatment of obesity.
test two: Chinese medicine composition of the present invention is to the clinical observation on the therapeutic effect of obesity volunteer patient
One, case and diagnostic criteria
1, Western medicine diagnose standard:
Draft according to " redefining of the fat and treatment in the Asian-Pacific area " regarding obesity disease diagnostic criteria:
(1) be above standard 20%-30% or BMI of body weight of body weight is Mild Obesity at 26-30;
(2) be above standard 30%-50% or BMI of body weight of body weight is central obesity at 30-40;
(3) be above standard body weight more than 50% or BMI of body weight is greater than 40 for severe simple obesity.
2, tcm diagnosis standard:
Be spleen asthenia and dampness retention, gastric heat dampness, stagnation of QI due to depression of the liver, deficiency of spleen-YANG and kidneyYANG, yin asthenia generating intrinsic heat totally five types according to simple obesity Syndrome Differentiation of Traditional Chinese Medicine, concrete manifestation is as follows:
(1) spleen asthenia and dampness retention---obesity, muscle pine he, companion's spiritlessness and weakness, limbs are tired heavy, indigestion and loss of appetite loose stool, and urine amount is few, and enlarged tongue is beaten with a stick greasy, deep,thready and forceless pulse.
(2) gastric heat dampness---obesity, rapid digestion of food and polyorexia, halitosis is unpleasant, thirst and desire for cold drink, and companion's feeling of fullness in the head is dizzy, and limbs are heavy, is disinclined to action, yellow urine, constipation with dry stool, red tongue with yellowish and greasy fur, slippery and rapid pulse.
(3) stagnation of QI due to depression of the liver---obesity is too fat to move, feeling of fullness and disecomfort in the chest and hypochondrium, being irritable and getting angry easily, insomnia and dreamful sleep, polydipsia polyphagia, bitter taste pharynx thousand, the visible distending pain of the breast of women or lower abdominal distention pain, and menoxenia or amenorrhea, red tongue with thin fur is white, stringy pulse.
(4) deficiency of spleen-YANG and kidneyYANG---obesity, spiritlessness and weakness, coldness of the body with chills, waist soreness, impotence and premature ejaculation, cold womb is infertile, soft stool, clear urine in large amounts, deep,thready and forceless pulse, and tongue is white, and body of the tongue is light red.
(5) yin asthenia generating intrinsic heat---obesity, feels dizzy, and feeling of fullness in the head is had a headache, and dysphoria with feverish sensation in the chest palms and soles, lumbago is aching and limp, thready and rapid pulse slightly stringy pulse, thin lingual fur, red tip of the tongue.
Two, clinical trial
1, physical data
Screen the clinical volunteer patients of obesity that 480 examples meet above-mentioned diagnostic criteria, the age is 10 years old-60 years old, and 33 years old mean age, men and women half and half.Be divided into matched group, treatment A group, treatment B group and treatment C group at random, often organize 120 people, four groups of influence factors such as patient age, symptom, through statistical procedures, there was no significant difference, meets a point set condition.
2, Therapeutic Method
Matched group: take orlistat (Chongqing Dinglian Pharmaceutical Co., Ltd.'s production), each 2, every day 2 times, be used in conjunction 30 days.
Treatment A, B, component C do not take the made tablet of the embodiment of the present invention 1,2,3, each 2, every day 2 times, are used in conjunction 30 days.
3, evaluation of clinical curative effect standard
The criterion of therapeutical effect for the treatment of Simple Obesity, that is:
(1) clinical cure: Body Mass Index drops to less than 26, related symptoms disappears;
(2) effective: Body Mass Index declines and is more than or equal to 4, and related symptoms disappears substantially;
(3) effective: Body Mass Index declines and is more than or equal to 2, and related symptoms alleviates;
(4) invalid: Body Mass Index drop-out value is less than 2, and related symptoms does not alleviate.
4, therapeutic outcome
Table 2 therapeutic effect
Group Number of cases Clinical recovery (rate) Effective Effectively Invalid Total effective rate
Treatment A group 120 75（62.5%） 20 16 9 92.5%
Treatment B group 120 73（60.8%） 19 18 10 91.7%
Treatment C group 120 70（58.3%） 20 18 12 90.0%
Matched group 120 66（（55%） 18 16 20 83.3%
5, conclusion
From clinical cure rate and total effective rate, embodiment of the present invention Chinese medicine composition clinical cure rate is all greater than 55%, and total effective rate is greater than 90%, higher than clinical recovery rate and the total effective rate of matched group, wherein with treatment group A and embodiment 1 best results.As can be seen here, Chinese medicine composition of the present invention is relative to Western medicine, and treatment of obesity has significant curative effect.All experimenters are through physical examination, and the security inspections such as blood, routine urinalysis, electrocardiogram, hepatic and renal function, it is safe and effective that further proved invention is used for the treatment of obesity, has the value applied.

Claims (7)

1. have a Chinese medicine composition for fat-reducing effect, it is characterized in that, the prescription of described Chinese medicine composition is formed by the Chinese drug preparation of following weight parts:
6-16 part, Fructus Crataegi 10-12 part, Semen Persicae 8-12 part, Pericarpium Citri Reticulatae 6-12 part and Radix Glycyrrhizae 2-10 part in Herba Viticis Cannabifoliae 10-20 part, Rhizoma Alismatis 12-20 part, Folium Nelumbinis 10-20 part, Radix Curcumae 8-22 part, Cortex Magnoliae Officinalis 8-14 part, Poria 8-12 part, Radix Angelicae Sinensis 6-12 part, chicken gold.
2. the Chinese medicine composition with fat-reducing effect according to claim 1, is characterized in that, in the prescription of described Chinese medicine composition, each medical material weight portion is:
In Herba Viticis Cannabifoliae 10-20 part, Rhizoma Alismatis 12 parts, 10 parts, Folium Nelumbinis, Radix Curcumae 8 parts, Cortex Magnoliae Officinalis 8 parts, 8 parts, Poria, Radix Angelicae Sinensis 6 parts, chicken gold 6 parts, Fructus Crataegi 10 parts, 8 parts, Semen Persicae, Pericarpium Citri Reticulatae 6 parts and 2 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition with fat-reducing effect according to claim 1, is characterized in that, in the prescription of described Chinese medicine composition, each medical material weight portion is:
In Herba Viticis Cannabifoliae 10-20 part, Rhizoma Alismatis 20 parts, 20 parts, Folium Nelumbinis, Radix Curcumae 22 parts, Cortex Magnoliae Officinalis 14 parts, 12 parts, Poria, Radix Angelicae Sinensis 12 parts, chicken gold 16 parts, Fructus Crataegi 12 parts, 12 parts, Semen Persicae, Pericarpium Citri Reticulatae 12 parts and 10 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition with fat-reducing effect according to claim 1, is characterized in that, in the prescription of described Chinese medicine composition, each medical material weight portion is:
In Herba Viticis Cannabifoliae 10-20 part, Rhizoma Alismatis 16 parts, 14 parts, Folium Nelumbinis, Radix Curcumae 14 parts, Cortex Magnoliae Officinalis 10 parts, 10 parts, Poria, Radix Angelicae Sinensis 10 parts, chicken gold 12 parts, Fructus Crataegi 10 parts, 10 parts, Semen Persicae, Pericarpium Citri Reticulatae 8 parts and 6 parts, Radix Glycyrrhizae.
5., according to the arbitrary described Chinese medicine composition with fat-reducing effect of claim 1-4, it is characterized in that, the preparation method of described Chinese medicine composition comprises the following steps:
Step 1: get Herba Viticis Cannabifoliae and wash away impurity, crushed after being dried, crosses 60-80 mesh sieve, obtains coarse powder, coarse powder is placed in supercritical carbon dioxide extraction apparatus, the 30-45% volume fraction adding coarse powder weight is the ethanol of 60-85%, and regulation and control carbon dioxide flow is 15 ~ 20L/h, and extracting pressure is 15 ~ 20MPa, extraction temperature is 40 ~ 60 DEG C, extraction time is 1.5 ~ 2h, and decompression separation obtains Herba Viticis Cannabifoliae extract, retains Herba Viticis Cannabifoliae residue;
Step 2: take Rhizoma Alismatis, Radix Curcumae, Cortex Magnoliae Officinalis, Poria and Radix Angelicae Sinensis respectively in proportion, pulverize after cleaning, drying, merge coarse powder, add Herba Viticis Cannabifoliae residue, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, and microwave power is 400-600W, Extracting temperature is 40-60 DEG C, filter and retain filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract A;
Step 3: take Folium Nelumbinis in proportion respectively, in chicken gold, Fructus Crataegi, Semen Persicae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, pulverize after cleaning, drying, merge coarse powder, and merge with the filtering residue of step 2, add the water of medical material gross weight 8-12 times amount, reflux, extract, 2-3 time, each 3-6 hour, filter, merging filtrate, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract B;
Step 4: merge Herba Viticis Cannabifoliae extract, extract A and extract B, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.
6., according to the arbitrary described Chinese medicine composition with fat-reducing effect of claim 1-4, it is characterized in that, described Chinese medicine composition is made into granule, tablet, capsule, pill, oral liquid and powder.
7., according to the arbitrary described preparation method with the Chinese medicine composition of fat-reducing effect of claim 1-4, it is characterized in that, comprise the following steps:
Step 1: get Herba Viticis Cannabifoliae and wash away impurity, crushed after being dried, crosses 60-80 mesh sieve, obtains coarse powder, coarse powder is placed in supercritical carbon dioxide extraction apparatus, the 30-45% volume fraction adding coarse powder weight is the ethanol of 60-85%, and regulation and control carbon dioxide flow is 15 ~ 20L/h, and extracting pressure is 15 ~ 20MPa, extraction temperature is 40 ~ 60 DEG C, extraction time is 1.5 ~ 2h, and decompression separation obtains Herba Viticis Cannabifoliae extract, retains Herba Viticis Cannabifoliae residue;
Step 2: take Rhizoma Alismatis, Radix Curcumae, Cortex Magnoliae Officinalis, Poria and Radix Angelicae Sinensis respectively in proportion, pulverize after cleaning, drying, merge coarse powder, add Herba Viticis Cannabifoliae residue, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, and microwave power is 400-600W, Extracting temperature is 40-60 DEG C, filter and retain filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract A;
Step 3: take Folium Nelumbinis in proportion respectively, in chicken gold, Fructus Crataegi, Semen Persicae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, pulverize after cleaning, drying, merge coarse powder, and merge with the filtering residue of step 2, add the water of medical material gross weight 8-12 times amount, reflux, extract, 2-3 time, each 3-6 hour, filter, merging filtrate, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract B;
Step 4: merge Herba Viticis Cannabifoliae extract, extract A and extract B, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.
CN201510966269.XA 2015-12-22 2015-12-22 Traditional Chinese medicine composition with weight reducing effect and preparation method of traditional Chinese medicine composition Withdrawn CN105343808A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106376664A (en) * 2016-08-26 2017-02-08 陈德忠 Pathogenic fire lowering tea
CN109893643A (en) * 2019-03-19 2019-06-18 南京星银药业集团有限公司 A kind of composition and preparation method thereof for treating obesity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106376664A (en) * 2016-08-26 2017-02-08 陈德忠 Pathogenic fire lowering tea
CN109893643A (en) * 2019-03-19 2019-06-18 南京星银药业集团有限公司 A kind of composition and preparation method thereof for treating obesity

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Application publication date: 20160224