CN109893643A - A kind of composition and preparation method thereof for treating obesity - Google Patents
A kind of composition and preparation method thereof for treating obesity Download PDFInfo
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- CN109893643A CN109893643A CN201910209433.0A CN201910209433A CN109893643A CN 109893643 A CN109893643 A CN 109893643A CN 201910209433 A CN201910209433 A CN 201910209433A CN 109893643 A CN109893643 A CN 109893643A
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Abstract
The invention discloses a kind of compositions and preparation method thereof for treating obesity, include following each component: Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis, lotus leaf, glycerol, plants essential oil and eptifibatide, preparation method are as follows: Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis uniformly mix, add water, after cooking, filtering, obtain brew water, it is cooling, eptifibatide, glycerol, plants essential oil is added, after being mixed evenly, homogeneous, immerse non-woven fabric plate, after immersion low temperature drying to get.The present composition has apparent antiobesity action and auxiliary lipid-lowering function, and effect is obvious.
Description
Technical field
The present invention relates to field of medicaments, and in particular to a kind of composition and preparation method thereof for treating obesity.
Background technique
Obesity is a kind of chronic metabolic disease, can cause to secrete metabolic system disease, cardiovascular disease, respiratory system
The multiple complications such as disease, genital system diseases, usually as caused by the interaction of many factors such as heredity, environment, usual table
It is now weight gain caused by body fat abnormal distribution or accumulation excessively.Obesity group grows rapidly in world wide, about
After starting from World War II.There is becoming for the obvious obesity of population due to economically developed and overnutrition in western countries
Gesture becomes increasingly severe health problem.Developing country is unreasonable due to dietary structure, and incidence of obesity is also year by year
It is soaring.Chinese obese patient's dramatically increases, then appear in the 1980s reform and opening-up after.Clinically diagnosis it is fat with
Body mass index (BMI) i.e. square (m of weight (kg) and height2) ratio be standard, specific standards are formulated by WHO, with regard to Asia
The constitution of regional crowd and its and the characteristics of obesity-related disease for, the BMI index of normal person be between 18.5-24.9,
Be between 25-27.4 it is overweight, 27.5 or more be obesity.It is fat not only to influence beauty, but also bring the health problem of patient very
It is more, such as the diseases such as diabetes, hypertension, hyperlipidemia, coronary heart disease, sleep Apnea Syndrome syndrome, polycystic ovary syndrome, it makes
At the various problems such as the daily life puzzlement of patient, infertile, serious puzzlement is brought for patient and its family.There is research aobvious
Show, obesity makes patient's life expectancy averagely reduce 6-7, and wherein serious fatness makes male's life expectancy reduce 20 years, female
Property reduce 5 years, in the U.S., obesity is the common cause of death of second for being only second to smoke.The obese people of current China is
Reach 90,000,000, wherein about 12,000,000 severe simple obesities, have ranked the first in the world, also seriously puzzlement Chinese residents are normal for problem of obesity
Life.
With keep on a diet, keep fit through sport, compared with gastrointestinal surgery, gene therapy method, drug therapy obesity is a kind of most square
Just, most popular supplementary means.Currently, slimming drugs are potentially certain although the trend grown is presented in the market of slimming drugs
The side effect and adverse reaction of degree are that current research is unavoidable, and for example, a big chunk slimming drugs have after
Increased heart rate, anorexia, blood pressure increase, are nervous, insomnia, increasing the adverse reactions such as depressed and suicide risk.Part as a result,
Oneself slimming medicine through listing oneself through being withdrawn market.Therefore, obviously oneself becomes mesh the problem of security risk existing for slimming drugs
The preceding widely used huge challenge of slimming drugs.Therefore, it is badly in need of one kind safely and effectively, and the drug of Small side effects occurs.
Summary of the invention
A kind of composition for treating obesity that can be solved the above problems the object of the present invention is to provide one kind and its preparation
Method.
The present invention is achieved through the following technical solutions:
A kind of composition for treating obesity, which is characterized in that the composition specifically include that Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis, lotus leaf,
Glycerol, plants essential oil and eptifibatide.
A kind of composition for treating obesity, which is characterized in that the composition of each component in the composition are as follows:
2 ~ 15g of Radix Angelicae Sinensis；
2 ~ 15g of rheum officinale；
2 ~ 15g of rhizoma alismatis；
0.2 ~ 1.5ml of glycerol；
0.2 ~ 1.5ml of plants essential oil；
0.02 ~ 0.15g of eptifibatide.
A kind of preparation method of composition that treating obesity comprising following steps:
Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis are successively weighed first uniformly to mix, adds water, and after cooking, filtering obtains brew water；
After the cooling of above-mentioned brew water, eptifibatide, glycerol, plants essential oil is added, after being mixed evenly, homogeneous must be mixed
Liquid；
Non-woven fabric plate will be immersed in above-mentioned mixed liquor, after immersion low temperature drying to get.
The preparation method, which is characterized in that the non-woven fabric plate size is 10 × 10 ~ 20cm2。
The preparation method, which is characterized in that the brew time is 20~40min.
The preparation method, which is characterized in that the revolving speed of the homogeneous be 3000~5000rpm, the time be 3~
5min。
The preparation method, which is characterized in that the low temperature drying temperature is 60~80 DEG C, and the time is 3~5h.
The composition is preparing the application in obesity treating medicine.
Compared with prior art, the beneficial effects of the present invention are: the present invention is with Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis, lotus leaf, glycerol
It is primary raw material with eptifibatide, safety is without side-effects.Experimental result shows that the present composition has and mitigates obese rat
Weight reduces the effect of triglyceride in serum and low density lipoprotein cholesterol, and effect is obvious, shows the present composition
With apparent antiobesity action and auxiliary lipid-lowering function.
Specific embodiment
The present invention is described in further details in order to which those skilled in the art is into one combined with specific embodiments below
Step ground understands the present invention.Embodiment should not limit as limiting of its scope.
Embodiment 1
A kind of composition for treating obesity, the weight of each component is constituted in the composition are as follows:
Radix Angelicae Sinensis 2g；
Rheum officinale 2g；
Rhizoma alismatis 2g；
Glycerol 0.2ml；
Plants essential oil 0.2ml；
Eptifibatide 0.02g.
Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis are successively weighed first uniformly to mix, adds water, and after cooking 30min, filtering obtains brew water；
After the cooling of above-mentioned brew water, eptifibatide, glycerol, plants essential oil, after being mixed evenly, 3000rpm homogeneous is added
30min obtains mixed liquor；
10 × 10cm will be immersed in above-mentioned mixed liquor2Non-woven fabric plate, after immersion, 60 DEG C of low temperature drying 3h to get.
Embodiment 2
A kind of composition for treating obesity, the weight of each component is constituted in the composition are as follows:
Radix Angelicae Sinensis 4g；
Rheum officinale 4g；
Rhizoma alismatis 4g；
Glycerol 0.4ml；
Plants essential oil 0.4ml；
Eptifibatide 0.04g.
Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis are successively weighed first uniformly to mix, adds water, and after cooking 30min, filtering obtains brew water；
After the cooling of above-mentioned brew water, eptifibatide, glycerol, plants essential oil, after being mixed evenly, 4000rpm homogeneous is added
30min obtains mixed liquor；
10 × 10cm will be immersed in above-mentioned mixed liquor2Non-woven fabric plate, after immersion, 80 DEG C of low temperature drying 5h to get.
Embodiment 3
A kind of composition for treating obesity, the weight of each component is constituted in the composition are as follows:
Radix Angelicae Sinensis 6g；
Rheum officinale 6g；
Rhizoma alismatis 6g；
Glycerol 0.6ml；
Plants essential oil 0.6ml；
Eptifibatide 0.06g.
Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis are successively weighed first uniformly to mix, adds water, and after cooking 30min, filtering obtains brew water；
After the cooling of above-mentioned brew water, eptifibatide, glycerol, plants essential oil, after being mixed evenly, 3000rpm homogeneous is added
30min obtains mixed liquor；
10 × 10cm will be immersed in above-mentioned mixed liquor2Non-woven fabric plate, after immersion, 60 DEG C of low temperature drying 3h to get.
Embodiment 4
A kind of composition for treating obesity, the weight of each component is constituted in the composition are as follows:
Radix Angelicae Sinensis 15g；
Rheum officinale 15g；
Rhizoma alismatis 15g；
Glycerol 1.5ml；
Plants essential oil 1.5ml；
Eptifibatide 0.15g.
Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis are successively weighed first uniformly to mix, adds water, and after cooking 30min, filtering obtains brew water；
After the cooling of above-mentioned brew water, eptifibatide, glycerol, plants essential oil, after being mixed evenly, 3000rpm homogeneous is added
30min obtains mixed liquor；
10 × 10cm will be immersed in above-mentioned mixed liquor2Non-woven fabric plate, after immersion, 60 DEG C of low temperature drying 3h to get.
Embodiment 5
A kind of composition for treating obesity, the weight of each component is constituted in the composition are as follows:
Radix Angelicae Sinensis 4g；
Rheum officinale 2g；
Rhizoma alismatis 6g；
Glycerol 1.0ml；
Plants essential oil 1.1ml；
Eptifibatide 0.08g.
Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis are successively weighed first uniformly to mix, adds water, and after cooking 30min, filtering obtains brew water；
After the cooling of above-mentioned brew water, eptifibatide, glycerol, plants essential oil, after being mixed evenly, 5000rpm homogeneous is added
30min obtains mixed liquor；
10 × 10cm will be immersed in above-mentioned mixed liquor2Non-woven fabric plate, after immersion, 80 DEG C of low temperature drying 3h to get.
Embodiment 6
A kind of composition for treating obesity, the weight of each component is constituted in the composition are as follows:
Radix Angelicae Sinensis 7g；
Rheum officinale 5g；
Rhizoma alismatis 3g；
Glycerol 0.9ml；
Plants essential oil 1.1ml；
Eptifibatide 0.07g.
Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis are successively weighed first uniformly to mix, adds water, and after cooking 30min, filtering obtains brew water；
After the cooling of above-mentioned brew water, eptifibatide, glycerol, plants essential oil, after being mixed evenly, 5000rpm homogeneous is added
30min obtains mixed liquor；
10 × 10cm will be immersed in above-mentioned mixed liquor2Non-woven fabric plate, after immersion, 80 DEG C of low temperature drying 3h to get.
Embodiment 7
A kind of composition for treating obesity, the weight of each component is constituted in the composition are as follows:
Radix Angelicae Sinensis 4g；
Rheum officinale 9g；
Rhizoma alismatis 7g；
Glycerol 0.8ml；
Plants essential oil 1.3ml；
Eptifibatide 0.06g.
Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis are successively weighed first uniformly to mix, adds water, and after cooking 30min, filtering obtains brew water；
After the cooling of above-mentioned brew water, eptifibatide, glycerol, plants essential oil, after being mixed evenly, 5000rpm homogeneous is added
30min obtains mixed liquor；
10 × 10cm will be immersed in above-mentioned mixed liquor2Non-woven fabric plate, after immersion, 80 DEG C of low temperature drying 3h to get.
Embodiment 8
SD male rat, 200 ± 20g of weight, cleaning grade.During raising, rat freely ingests and drinks water, and the light and shade period is 12 small
When, 20 ~ 25 DEG C of room temperature, relative humidity 40% ~ 60%, well-ventilated.Modeling, i.e., rat feeding maintains feed to see under barrier system
It examines 5 ~ 7 days, after the laundering period, blank rat gives maintenance forage feed, is set as blank group；Remaining gives for modeling rat
High-calorie feed is fed.It records weekly to appetite, surplus appetite, weighs in 1 time.After feeding 2 weeks, the big of high-calorie feed is given
Mouse is sorted by weight gain, eliminates the lower Diet resistant rat of weight gain.Data statistics, significant difference rat are successfully to make
Mould rat, screening weight are randomly divided into 4 groups positioned at preceding 40 successful modeling rat, every group 10, are set to model group, implement
1 group of example, 2 groups of embodiment and 3 groups of embodiment.Blank group still gives maintenance feed, remaining each group rat gives high-calorie feed
It feeds.The depilation of each group rat back.3 groups of example 1 group, 2 groups of embodiment, embodiment rats give embodiment 1 respectively, implement
Composition made from example 2, embodiment 3, is cut to 3 × 3cm2, it is affixed at rat depilation, daily 1 patch, continuous 6 weeks.It records weekly
To appetite, surplus appetite, weigh in 1 time.
Obesity index: Lee ' s index: Lee ' s index=weight (g) is surveyed after administration experiment1/3 ×103/ body is long (cm), and body is long
For the length from nose to anus；Serum Indexes measurement: fasting 24 hours after medication six weeks, anesthesia are cut open the belly and are taken from abdominal aorta
Blood, 3000rpm are centrifuged 10min, separate serum.Automatic clinical chemistry analyzer measure TG(triglycerides), LDL-C(low density lipoprotein
Protein cholesterol).
In research, using the feed formula of weight-reducing sexual function product evaluation method, filters out successfully modeling rat and carry out in fact
It tests.The results show that compared to the blank group, Lee ' s index, TG and the LDL-C of model group dramatically increase (P<0.05)；With model
Group is compared, embodiment each group rat Lee ' s index, TG and LDL-C significantly reduce (P<0.05).
1 each group Obesity of Rats index situation of table
Note: P < 0.05* compared with the control group, P < 0.05# compared with model group.
To sum up, experimental result show the present composition have mitigate obese rat weight, reduce triglyceride in serum with
The effect of low density lipoprotein cholesterol, and effect is obvious, shows that the present composition has apparent antiobesity action and auxiliary
Hypolipemic function.
The above description of the embodiment is only used to help understand the method for the present invention and its core ideas, should not be construed as to this hair
Bright limitation.
Claims (8)
1. a kind of composition for treating obesity, which is characterized in that the composition specifically includes that Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis, lotus
Leaf, glycerol, plants essential oil and eptifibatide.
2. a kind of composition for treating obesity as described in claim 1, which is characterized in that the weight of each component in the composition
Amount is constituted are as follows:
2 ~ 15g of Radix Angelicae Sinensis；
2 ~ 15g of rheum officinale；
2 ~ 15g of rhizoma alismatis；
0.2 ~ 1.5ml of glycerol；
0.2 ~ 1.5ml of plants essential oil；
0.02 ~ 0.15g of eptifibatide.
3. a kind of preparation method of composition described in claim 1 comprising following steps:
Radix Angelicae Sinensis, rheum officinale, rhizoma alismatis are successively weighed first uniformly to mix, adds water, and after cooking, filtering obtains brew water；
After the cooling of above-mentioned brew water, eptifibatide, glycerol, plants essential oil is added, after being mixed evenly, homogeneous must be mixed
Liquid；
Non-woven fabric plate will be immersed in above-mentioned mixed liquor, after immersion low temperature drying to get.
4. the preparation method as claimed in claim 3, which is characterized in that the non-woven fabric plate size is 10 × 10 ~ 20cm2。
5. preparation method as claimed in claim 3, which is characterized in that the brew time is 20~40min.
6. preparation method as claimed in claim 3, which is characterized in that the revolving speed of the homogeneous is 3000~5000rpm, time
For 3~5min.
7. preparation method as claimed in claim 3, which is characterized in that the low temperature drying temperature is 60~80 DEG C, the time 3
~5h.
8. composition described in claim 1 is preparing the application in obesity treating medicine.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111053829A (en) * | 2020-01-20 | 2020-04-24 | 广东药科大学 | Traditional Chinese medicine composition for treating abdominal obesity and preparation and external preparation thereof |
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2019
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| CN101167906A (en) * | 2007-11-14 | 2008-04-30 | 北京中科雍和医药技术有限公司 | Medicinal composition for reducing blood lipid and reducing weight and preparation process thereof |
| CN105343675A (en) * | 2015-12-09 | 2016-02-24 | 广东聚智诚科技有限公司 | Traditional Chinese medicine preparation for treating adiposis and preparation method thereof |
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| CN111053829A (en) * | 2020-01-20 | 2020-04-24 | 广东药科大学 | Traditional Chinese medicine composition for treating abdominal obesity and preparation and external preparation thereof |
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