CN110050816A - The dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients and preparation method - Google Patents
The dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients and preparation method Download PDFInfo
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- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D13/00—Finished or partly finished bakery products
- A21D13/06—Products with modified nutritive value, e.g. with modified starch content
- A21D13/062—Products with modified nutritive value, e.g. with modified starch content with modified sugar content; Sugar-free products
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- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/14—Organic oxygen compounds
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- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/14—Organic oxygen compounds
- A21D2/18—Carbohydrates
- A21D2/181—Sugars or sugar alcohols
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- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/14—Organic oxygen compounds
- A21D2/18—Carbohydrates
- A21D2/186—Starches; Derivatives thereof
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- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/36—Vegetable material
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Abstract
The invention belongs to food processing technology fields, and in particular to a kind of high-resistance starch rhizoma polygonati biscuit that suitable Diabetic Nephropathy patients are edible.The dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients provided by the present invention, the biscuit includes the primary raw material of following parts by weight: 80~120 parts of weak strength flour, 24~30 parts of resistant starch, 34~40 parts of peanut oil, 12~18 parts of xylitol, 3.5~5 parts of baking powder, 22~28 parts of rhizoma polygonati, 9~12 parts of egg.The rhizoma polygonati that the present invention selects is polygonatum cyrtonema, and Jing Gufa technique nine is steamed nine solarizations (yellow rice wine boiling) and processed, and is not necessarily to drying and crushing, simple and easy, rhizoma polygonati is from a wealth of sources, at low cost.Nine RHIZOMA POLYGONATI PREPARATA colors are shiny black, and matter profit is mellow, and such as maltosemalt sugar sweet in flavor, sweet tea is glutinous palatable, is broken into fourth and is added in biscuit, not only reduce nutriment loss to greatest extent, also improve the color and mouthfeel of biscuit.
Description
Technical field
The invention belongs to food processing technology fields, and in particular to a kind of edible resistance of suitable Diabetic Nephropathy patients
Starch rhizoma polygonati biscuit, further relates to the preparation method of above-mentioned biscuit.
Background technique
Diabetic nephropathy (DN) is that diabetes are most common and one of the microvascular complication of most serious and terminal phase kidney
The Main Etiological Factors of dirty disease (ESRD) have very high lethality, disability rate.DN institute in western countries' dialysis patient at present
It causes the number of ESRD to occupy first place, also rises to second in China.Based on the pathogenesis of DN complexity, patient relies solely on medicine
Object treatment can not control progression of the disease well, therefore the clinically multipair method that it uses complex treatment.And nutrition treatment
It is the Primary Care of each subject disease, alimentotheray plays in the treatment of DN as one for the treatment of diabetes " five drive carriage "
Very important effect.The nutrition treatment purpose of DN mainly controls blood glucose, protects renal function, principle of reatment is with high-quality low albumen
Based on diet.
Rhizoma polygonati is the common help class Chinese medicine of Chinese medicine, belongs to liliaceous plant, sweet in flavor, mild-natured, enters spleen, lung, kidney channel, according to
Compendium of Material Medica is recorded, and rhizoma polygonati is with " tonifying Qi kidney-nourishing, curing rheumatism, five viscera settling mend general debility, help muscles and bones, and resistance to cold and heat moistens the heart
Lung, nontoxic, long term usage macrobiosis of making light of one's life by commiting suicide is not hungry " effect.Principle active component is Siberian solomonseal rhizome polysaccharide, modern pharmacological studies have shown that it has
The effects of hypoglycemic, anti-oxidant feature.
Resistant starch (RS) is used as a kind of New Dietary Fiber, is defined as " the starch not absorbed by Healthy People small intestine
And its general name of catabolite ".Because its own is practically free of heat, in the characteristic that small enteral only has fraction to be digested, can rise
To reducing postprandial blood sugar, increasing satiety, to alleviate starvation, the work of DN patient blood glucose, improvement insulin resistance are effectively controlled
With.It is particularly suitable for patients with diabetes mellitus.
Biscuit is a kind of baked cake common in the modern life, because it is in good taste, price is low, convenient, battalion
The features such as supporting value height, easy long term storage is favored by people.Biscuit is many kinds of on the market, but belongs to high heat, high glycoform more
Conventional cookies, it is edible not to be suitable for Diabetic Nephropathy patients.
ZL201510738488.2 discloses a kind of rhizoma polygonati biscuit and its manufacture craft, and formula is flour 100~110
Part, 20~25 parts of rhizoma polygonati powder, 0.8~1 part of white sugar, 0.2~0.5 part of sodium bicarbonate, 0.1~0.3 part of edible salt, egg 10~15
Part, 1~2 part of matcha powder.Its preparation step is that 1~2min is mixed in rhizoma polygonati powder and flour, then sequentially adds bicarbonate
Sodium, egg, matcha powder, white sugar, edible salt stir 1~2min, are subsequently added into warm water and are stirred 1~2min, finally will stirring
Good dough is sent into mold, is subsequently placed into oven and is toasted, and baking temperature is 100~120 DEG C, and baking time is 1~
2min。
ZL 201810417706.6 discloses a kind of rhizoma polygonati cookie formulation and preparation method thereof, by the original of following parts by weight
Material component is made: 80~120 parts of Icing Sugar, 70~90 parts of honey, 10~30 parts of butter, 50~100 parts of egg liquid, Siberian solomonseal rhizome polysaccharide 5
~15 parts, 10~30 parts of skimmed milk power, 80~120 parts of quinoa flour, 350~450 parts of Self- raising flour.The invention meets popular
Edible, for often staying up late, Working Life is irregular that people of weak constitution's group energy is caused to play a role in health care.
In existing related rhizoma polygonati biscuit manufacture craft, biscuit is added into as raw material using rhizoma polygonati powder or Siberian solomonseal rhizome polysaccharide
In.This kind of technique the main problems are as follows: (1) honey, butter, Icing Sugar etc. are not suitable for the food of Diabetic Nephropathy patients
The addition of product auxiliary material is more, and obtained product heat is higher；(2) pulverization process need to be dried to rhizoma polygonati when making rhizoma polygonati biscuit,
Not only energy consumption improves, and during drying and crushing, generates certain influence to polysaccharide isoreactivity substance in rhizoma polygonati；(3) itself rhizoma polygonati
Color is bad, and brownish black is presented and easily leads to smashed rhizoma polygonati powder after high-temperature process and aoxidizes, color burn is produced
Biscuit sensory evaluation scores reduce；(4) raw sealwort has numb feeling in the tongue, stimulates throat, and palatability is poor.Therefore how effect is kept, changed
Kind mouthfeel is active material Siberian solomonseal rhizome polysaccharide in problem (5) the directly addition rhizoma polygonati of many years, and not only production cost increases, and is lost
Other preciousness ingredients in rhizoma polygonati original local flavor and rhizoma polygonati.
Also, rhizoma polygonati is only relied on to control DN patient blood glucose, improve insulin resistance, effect is limited, if will
It is in conjunction with resistant starch, if can reach superior effect, effect is not significant after alternatively the two combines, not
There is relevant document to disclose.Therefore, it is necessary to conduct further research for above-mentioned background.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of rhizoma polygonati biscuit suitable for Diabetic Nephropathy patients,
The present invention solve rhizoma polygonati itself to biscuit bring numb feeling in the tongue, stimulation throat, palatability is poor, nutritive loss is serious, biscuit at
The problems such as product color is bad, provided rhizoma polygonati biscuit is with cost is relatively low, nutritive loss is lower, biscuit finished product color is good, mouth
The feature felt.
The invention thinking of the present inventor is: in view of being previously mentioned in background technique, the present invention is in traditional Chinese medicine and pharmacy, nutrition
Under theoretical direction, using prevention and treatment in traditional Chinese and western DN as point of penetration, it is thinking that Chinese medicine conditioning, which combines nutrition treatment, can be had using RS
Effect control DN patient blood glucose, the action character for improving insulin resistance, are further introduced into the Chinese medicine rhizoma polygonati of integration of drinking and medicinal herbs classification,
Produce a kind of dedicated high-resistance starch rhizoma polygonati biscuit of DN patient.
Diabetic Nephropathy patients dedicated high-resistance starch rhizoma polygonati biscuit contains resistant starch and rhizoma polygonati in the biscuit, resists
Property starch accounts for the 4.8~8.9% of biscuit total weight, and rhizoma polygonati accounts for the 7.8~13% of biscuit total weight.
The biscuit is mainly to be prepared by the raw material of following parts by weight:
Weak strength flour 80~120, starch 24~30, peanut oil 34~40, xylitol 12~18, baking powder 3.5~5, rhizoma polygonati
22~28, egg liquid 9~12, water 25~35；
Wherein in starch containing 58~62% resistant starch.
Preferably, the proportion of each raw material are as follows: 100 parts of weak strength flour, 28 parts of starch, 36 parts of peanut oil, 15 parts of xylitol, bubble is beaten
4 parts of powder, 25 parts of rhizoma polygonati, 10 parts of egg liquid, 30 parts of water；
Wherein in starch containing 58~62% resistant starch.
Rhizoma polygonati is that wild polygonatum cyrtonema is prepared by nine steamings, nine solarization techniques, limited purchased from the in good health hall biotechnology in Jinan
Company.
Starch is preferably amylomaize.
Rhizoma polygonati is to be cut into the fritter that volume is 0.25~0.8cm3.
The preparation method of the dedicated high-resistance starch rhizoma polygonati biscuit of above-mentioned Diabetic Nephropathy patients, including following steps
It is rapid:
1) pretreatment of raw material: the wild polygonatum cyrtonema that nine steam nine solarization techniques is smashed, egg is dispersed as egg liquid, spare；
2) raw material mixes: taking xylitol to be added in peanut oil, sufficiently dismisses dissolution, is then added to egg liquid above-mentioned
In peanut oil, sufficiently dismiss to butyrous, then plus weak strength flour, starch, baking powder, rhizoma polygonati block sequentially add and stir evenly, then
Water is added, pinches into dough；
3) dough microwave ferments: the dough pinched being sealed with preservative film, is handled through microwave small fire, is then stood；
4) Biscuit mold forms: 3) the dough roll marks in is formed；
5) it toasts: preheating in advance, toast, bake to the golden yellow taking-up in biscuit surface；Obtain finished product biscuit.
Specifically, the preparation method of the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients, including following steps
It is rapid:
1) pretreatment of raw material: it is 0.25~0.8cm that the wild polygonatum cyrtonema that nine steam nine solarization techniques, which is broken into volume,3It is small
Block, egg is dispersed as egg liquid, spare；
2) raw material mixes: taking 12~18 parts of xylitols to be added in 34~40 portions of peanut oil, dissolution is sufficiently dismissed, then by 9
~12 parts of egg liquids are added three times in above-mentioned peanut oil, are sufficiently dismissed to butyrous, and 80~120 parts of weak strength flours, 24 are added
~30 parts of starch, 3.5~5 parts of baking powders, 22~28 parts of rhizoma polygonati blocks are sequentially added and are stirred evenly, and add 25~35 parts of water,
Pinch into dough；
3) dough microwave ferments: the dough pinched being sealed with preservative film, 15~20s is handled through microwave small fire, then in 3
10~15min is stood at~5 DEG C；
4) Biscuit mold forms: 3) the dough roll marks in is formed；
5) toast: oven face fire is adjusted to 160~180 DEG C, and the fire in a stove before fuel is added is adjusted to 140~160 DEG C, preheats 9~12min in advance, dries
Roasting 20~25min of time, is baked to the golden yellow taking-up in biscuit surface；Obtain finished product biscuit.
Preferably, the preparation method of the dedicated high-resistance starch rhizoma polygonati biscuit of above-mentioned Diabetic Nephropathy patients, including under
The step of stating:
1) pretreatment of raw material: it is 0.6cm that the wild polygonatum cyrtonema that nine steam nine solarization techniques, which is broken into volume,3Fritter, chicken
Egg beaten is spare at egg liquid；
2) raw material mixes: taking 15 parts of xylitols to be added in 36 portions of peanut oil, dissolution is sufficiently dismissed, then by 10 parts of egg liquids
It is added three times in above-mentioned peanut oil, sufficiently dismisses to butyrous, add 100 parts of weak strength flours, 28 parts of starch, 4 parts of bubbles and beat
Powder, 25 parts of rhizoma polygonati blocks are sequentially added and are stirred evenly, and are added 30 parts of water, are pinched into dough；
3) dough microwave ferments: the dough pinched being sealed with preservative film, 15~20s is handled through microwave small fire, then in 4
12min is stood at DEG C；
4) Biscuit mold forms: 3) the dough roll marks in is formed；
5) toast: oven face fire is adjusted to 170 DEG C, and the fire in a stove before fuel is added is adjusted to 150 DEG C, preheats 10min, baking time 23min in advance, bakes
To the golden yellow taking-up in biscuit surface；Obtain finished product biscuit.
Compared with existing inventive technique, the invention has the following advantages:
(1) there is apparent prevention and treatment to make diabetes after resistant starch of the present invention, with rhizoma polygonati synergistic effect
With better than single resistant starch either preventive and therapeutic effect of the rhizoma polygonati to diabetes；
(2) rhizoma polygonati of the present invention, be polygonatum cyrtonema, Jing Gufa technique nine steam nine shine (yellow rice wine boiling) process and
At, be not necessarily to drying and crushing, simple and easy, rhizoma polygonati is from a wealth of sources, and at low cost, nine RHIZOMA POLYGONATI PREPARATA colors are shiny black, matter profit it is mellow, it is sweet in flavor such as
Maltosemalt sugar, sweet tea is glutinous palatable, is broken into fourth and is added in biscuit, not only reduces nutriment loss to greatest extent, also improves
The color and mouthfeel of biscuit；Avoid the given offending numb feeling in the tongue of people's bring of rhizoma polygonati itself；
(3) present invention selected raw material such as xylitol, peanut oil not only guarantees the mouthfeel of biscuit, can also reduce biscuit
The intake of heat and trans-fatty acid, xylitol does not need insulin adjusting in human body metabolism, therefore can't increase blood
Sugar also has having certain effect for prevention and treatment diabetes；
(4) various preservatives are avoided and additive brings human body without any preservative and additive in the present invention
Side effect, and product of the invention meets state food safety standard, highly-safe, of great advantage to human health.
Detailed description of the invention
Fig. 1 is high-resistance starch rhizoma polygonati biscuit production flow diagram of the invention；
Fig. 2 is the photo of the biscuit of the embodiment of the present invention 1.
Specific embodiment
In order to make those skilled in the art better understand the present invention, the present invention is carried out now in conjunction with specific embodiment
It is further to illustrate.
Rhizoma polygonati: it is purchased from producer: the in good health hall Bioisystech Co., Ltd in Jinan.
Embodiment 1
The preparation method of the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients, includes the following steps:
1) pretreatment of raw material: it is 0.25~0.8cm that the wild polygonatum cyrtonema that nine steam nine solarization techniques, which is broken into volume,3It is small
Block, egg is dispersed as egg liquid, spare；
2) raw material mixes: taking 15 parts of xylitols to be added in 36 portions of peanut oil, dissolution is sufficiently dismissed, then by 10 parts of egg liquids
It is added three times in above-mentioned peanut oil, sufficiently dismisses to butyrous, add 100 parts of weak strength flours, 28 parts of starch, 4 parts of bubbles and beat
Powder, 25 parts of rhizoma polygonati blocks are sequentially added and are stirred evenly, and are added 30 parts of water, are pinched into dough；
3) dough microwave ferments: the dough pinched being sealed with preservative film, 15~20s is handled through microwave small fire, then in 4
12min is stood at DEG C；
4) Biscuit mold forms: 3) the dough roll marks in is formed；
5) toast: oven face fire is adjusted to 170 DEG C, and the fire in a stove before fuel is added is adjusted to 150 DEG C, preheats 10min, baking time 23min in advance, bakes
To the golden yellow taking-up in biscuit surface；Obtain finished product biscuit.
Embodiment 2
The preparation method of the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients, includes the following steps:
1) pretreatment of raw material: it is 0.25cm that the wild polygonatum cyrtonema that nine steam nine solarization techniques, which is broken into volume,3Fritter, chicken
Egg beaten is spare at egg liquid；
2) raw material mixes: taking 12 parts of xylitols to be added in 34 portions of peanut oil, sufficiently dismisses dissolution, then by 9 parts of egg liquids point 3
It is secondary to be added in above-mentioned peanut oil, it sufficiently dismisses to butyrous, adds 80 parts of weak strength flours, 24 parts of starch, 3.5 parts of bubbles and beat
Powder, 22 parts of rhizoma polygonati blocks are sequentially added and are stirred evenly, and are added 25 parts of water, are pinched into dough；
3) dough microwave ferments: the dough pinched being sealed with preservative film, 15s is handled through microwave small fire, then at 3 DEG C
Stand 10~15min；
4) Biscuit mold forms: 3) the dough roll marks in is formed；
5) toast: oven face fire is adjusted to 160 DEG C, and the fire in a stove before fuel is added is adjusted to 140 DEG C, preheats 9min, baking time 20min in advance, bakes
To the golden yellow taking-up in biscuit surface；Obtain finished product biscuit.
Embodiment 3
The preparation method of the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients, includes the following steps:
1) pretreatment of raw material: it is 0.8cm that the wild polygonatum cyrtonema that nine steam nine solarization techniques, which is broken into volume,3Fritter, chicken
Egg beaten is spare at egg liquid；
2) raw material mixes: taking 18 parts of xylitols to be added in 40 portions of peanut oil, sufficiently dismisses dissolution, then by 12 parts of egg liquids point
It is added in above-mentioned peanut oil for 3 times, sufficiently dismisses to butyrous, add 120 parts of weak strength flours, 30 parts of starch, 5 parts of bubbles and beat
Powder, 28 parts of rhizoma polygonati blocks are sequentially added and are stirred evenly, and are added 35 parts of water, are pinched into dough；
3) dough microwave ferments: the dough pinched being sealed with preservative film, 20s is handled through microwave small fire, then at 5 DEG C
Stand 15min；
4) Biscuit mold forms: 3) the dough roll marks in is formed；
5) toast: oven face fire is adjusted to 180 DEG C, and the fire in a stove before fuel is added is adjusted to 160 DEG C, preheats 12min, baking time 25min in advance, bakes
To the golden yellow taking-up in biscuit surface；Obtain finished product biscuit.
Embodiment 4
The preparation method of the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients, includes the following steps:
1) pretreatment of raw material: it is 0.4cm that the wild polygonatum cyrtonema that nine steam nine solarization techniques, which is broken into volume,3Fritter, chicken
Egg beaten is spare at egg liquid；
2) raw material mixes: taking 16 parts of xylitols to be added in 38 portions of peanut oil, sufficiently dismisses dissolution, then by 10 parts of egg liquids point
Be added in above-mentioned peanut oil for 3 times, sufficiently dismiss to butyrous, add 90 parts of weak strength flours, 27 parts of starch, 4 parts of baking powders,
25 parts of rhizoma polygonati blocks are sequentially added and are stirred evenly, and are added 32 parts of water, are pinched into dough；
3) dough microwave ferments: the dough pinched being sealed with preservative film, 18s is handled through microwave small fire, then at 4 DEG C
Stand 12min；
4) Biscuit mold forms: 3) the dough roll marks in is formed；
5) toast: oven face fire is adjusted to 175 DEG C, and the fire in a stove before fuel is added is adjusted to 155 DEG C, preheats 12min, baking time 20min in advance, bakes
To the golden yellow taking-up in biscuit surface；Obtain finished product biscuit.
Comparative example 1
It is with the difference of embodiment 1, resistant starch is replaced with to the common starch of identical weight number, remaining and implementation
Example 1 is identical.
Comparative example 2
It is with the difference of embodiment 1, does not use rhizoma polygonati, it is same as Example 1 that remaining raw material enters step.
Embodiment 5
In order to verify rhizoma polygonati biscuit provided by the present invention, present inventor has performed compliance test result tests below:
One, the sensory evaluation of high RS rhizoma polygonati biscuit
High RS rhizoma polygonati biscuit, that is, high-resistance starch rhizoma polygonati biscuit；
It is preferred that going out 10 there are the personnel (men and women is fifty-fifty) for experience of judging to set up scoring group, it is yellow to high RS using blind mark method
Smart biscuit carries out sensory evaluation.Comprehensive score is carried out according to 5 appearance of biscuit, color, smell, mouthfeel, form indexs, is investigated
The quality of high RS rhizoma polygonati biscuit.Evaluation criterion is shown in Table 1.
The sensory evaluation criteria of the RS high rhizoma polygonati biscuit of table 1
Specific evaluation result is shown in Table 2.
The RS high rhizoma polygonati biscuit sensory evaluation scores of table 2
Can be seen that in comparative example 1 from the data in above table uses common starch to make with the inventive method
Biscuit, appearance, color and smell are suitable with the product in the embodiment of the present invention 1~4, but its mouthfeel and institutional framework are wanted
The biscuit being slightly inferior in the embodiment of the present invention 1~4.
Unsuitable with Examples 1 to 4 using its score of biscuit made by rhizoma polygonati in comparative example 2, this explanation is added without Huang
The biscuit of essence is very nearly the same with the biscuit in Examples 1 to 4 in terms of appearance, mouthfeel, smell.
Two, nutritional ingredient and RS content are carried out to the high-resistance starch rhizoma polygonati biscuit using the method production in embodiment 1
It is detected, the specific detection method is as follows:
(1) it is detected according to 21922~2008 food nutrient composition basic terms method of GB/Z total in high RS rhizoma polygonati biscuit
Energy and carbohydrate content；
(2) high RS is detected according to the measuring method of 5009.5~2016 national food safety standard Protein in Food of GB
Protein content in rhizoma polygonati biscuit；
(3) high RS Huang is detected according to measuring method fatty in 5009.6~2016 national food safety standard food of GB
Fat content in smart biscuit；
(4) according to the high RS of measuring method detection of potassium, sodium in 5009.91~2017 national food safety standard food of GB
Sodium content in rhizoma polygonati biscuit；
(5) content of RS in high RS rhizoma polygonati biscuit original powder is measured referring to AOAC2002.02 method.
Detection concrete outcome is shown in Table 3.
The RS high rhizoma polygonati biscuit nutrient component meter of table 3
| Project | Every 100g | NRV% |
| Energy | 2084KJ | 25% |
| Protein | 6.2g | 10% |
| Fat | 21.5g | 36% |
| Carbohydrate | 69.6g | 23% |
| Sodium | 267mg | 13% |
Measuring RS content in high RS rhizoma polygonati biscuit original powder is 12.9 ± 0.6g/100g.
Three, glycemic index (GI) detection is carried out to high RS rhizoma polygonati biscuit made by embodiment 1, use is in-vitro simulated
Dietary fiber method carries out external GI value Forecast and Estimate to high RS rhizoma polygonati biscuit using white bread as control；And it is with glucose
Control carries out internal digestic property measurement to high RS rhizoma polygonati biscuit.Specific testing result is shown in Table 4 to table 7.As the result is shown: high RS is yellow
The digestion rate of smart biscuit has the function of slowing down starch digestion rate, high RS rhizoma polygonati cake significantly lower than control fine flour package
Solid carbon dioxide solution index is about 46.45, and estimation glycemic index is 65.21, belongs to middle GI food.
The RS high rhizoma polygonati biscuit of table 4 is horizontal with white bread 2h difference time point percent hydrolysis
Note: a P < 0.05 compared with fine flour package
The RS high rhizoma polygonati biscuit of table 5 hydrolyzes index and estimation glycemic index
| Group | HI | EGI |
| White bread | 100 | 94.61 |
| High RS rhizoma polygonati biscuit | 46.45±0.32 | 65.21 |
6 oral glucose of table and 2h difference time point blood glucose level after high RS rhizoma polygonati biscuit
| Tested material | 0min | 15min | 30min | 45min | 60min | 90min | 120min |
| Glucose | 4.99±0.43 | 7.55±0.74 | 8.50±1.29 | 7.68±1.34 | 7.01±0.82 | 6.13±0.63 | 4.98±1.13 |
| High RS rhizoma polygonati biscuit | 4.88±0.34 | 5.79±0.59a | 6.34±0.57a | 6.47±0.87a | 6.18±0.72a | 5.48±0.34a | 5.46±0.33 |
Note: a P < 0.05 compared with glucose
The RS high rhizoma polygonati biscuit GI value of table 7 and GL
| Food name | GI value | GL value |
| Glucose | 100 | - |
| High RS rhizoma polygonati biscuit | 53.56±16.03 | 6.71 |
Clinical verification is carried out using the high RS rhizoma polygonati biscuit of the method production in embodiment 1.It is vertical to obtain attached province, Shandong University
After Hospital Ethical Committee's written instructions, screen during in July, 2018~2018 year November in the outpatient service of Shandong Prov. Hospital division of endocrinology
And the early diabetic nephropathy patient that inpatient department is treated is as research object.35 people of case, specifying information are included in screening altogether
It is shown in Table 8.Using simple randomizing method, patient is divided into experimental group and control group.Wherein 19 people of experimental group, 16 people of control group.It is real
Testing group is high RS rhizoma polygonati biscuit intervention group, and control group is low albumen biscuit intervention group.Intervention time be 12 weeks, experimental group with compare
Group patient is all made of the eating method of equal energy substitution, during test in daily lunch and dinner use respectively 30g biscuit (by
Shandong Prov. Hospital Nutriology Dept. dining room production) carry out staple food substitution.It is dry to the diet of early diabetic nephropathy patient to inquire into it
Pre- effect, and further inquire into the feasibility for carrying out diet intervention to diabetic using biscuit as staple food.Test result tool
Body is shown in Table 8 to table 11.
It is weary about DN patient's glycosylated hemoglobin, inflammatory factor and patient's dry mouth and throat, burnout respectively in table 8~11
The data of the symptoms such as power, polyorexia, palpitation and insomnia, limb tingling pain.
8 crowd's Basic Information Table of table
9 patients before and after intervention blood glucose index of correlation of table compares
| Group | 0 week | 12 weeks | 0-12 weeks difference |
| FBG(mmol/L) | |||
| Experimental group | 7.8±3.6 | 7.7±3.3 | -0.1±2.8 |
| Control group | 8.1±1.9 | 7.4±2.2 | -0.6±2.9 |
| HbA1c (%) | |||
| Experimental group | 8.1±1.6 | 7.6±1.4 | -0.5±0.7a |
| Control group | 7.8±1.5 | 7.6±1.6 | -0.25±0.7 |
Note: patients before and after intervention compares P < 0.05 in a group
10 patients before and after intervention blood lipid of table compares
Note: patients before and after intervention compares P < 0.05 in a group；Compare P < 0.05 between b group
11 patients before and after intervention renal function index of table compares
| Group | 0 week | 12 weeks | 0-12 weeks difference |
| Blood uric acid (μm ol/L) | |||
| Experimental group | 329.5±80.8 | 328.5±82.7 | -1.0±39.0 |
| Control group | 311.8±86.6 | 316.0±58.4 | 4.2±70.7 |
| Serum creatinine (μm ol/L) | |||
| Experimental group | 57.2±16.9 | 71.3±16.7 | 14.2±4.5a |
| Control group | 87.8±87.0 | 93.7±110.0 | 6.1±24.2 |
| Plasma wrea (mmol/L) | |||
| Experimental group | 6.3±1.5 | 6.5±1.6 | 0.2±1.6 |
| Control group | 6.4±4.6 | 8.0±8.5 | 1.6±4.0 |
Note: patients before and after intervention compares P < 0.05 in a group
12 patients before and after intervention albumen index of correlation situation of change of table
Note: compare P < 0.05 between a group
13 patients before and after intervention blood plasma oxidative stress of table compares
| Group | 0 week | 12 weeks | 0-12 weeks difference |
| SOD(U/mL) | |||
| Experimental group | 33.0±7.7 | 54.8±9.3 | 21.9±11.9a |
| Control group | 29.7±3.7 | 55.1±3.9 | 25.3±5.7a |
| MDA(mmol/L) | |||
| Experimental group | 6.9±2.4 | 7.7±2.0 | 0.8±2.4 |
| Control group | 5.3±1.03 | 7.2±1.9 | 2.0±1.2a |
Note: patients before and after intervention compares P < 0.05 in a group
14 patients before and after intervention blood plasma inflammatory factor level of table compares
Note: patients before and after intervention compares P < 0.05 in a group
15 patients before and after intervention tcm syndrome scale score of table compares
Note: patients before and after intervention compares P < 0.05 in a group；Compare P < 0.05 between b group
Can be seen that high RS rhizoma polygonati biscuit from above clinical trial can significantly reduce early stage DN patient's HbAle egg
It is white, have effects that in terms of controlling blood glucose certain.It is remarkably improved early stage DN patients serum T-SOD level, significantly reduces IL-6
The level of inflammatory factor prompts high RS rhizoma polygonati biscuit can be by enhancing body antioxidant levels and reduction body inflammatory reaction water
It is flat to play the role of centainly protecting kidney.Early stage DN patient's dry mouth and throat, fatigue and weakness, polyorexia, palpitaition can also be improved
The symptoms such as insomnia, limb tingling pain.
Resistant starch and rhizoma polygonati are verified to the function influence of diabetic nephropathy by zoopery.DN rat model is constructed,
RS, rhizoma polygonati and synergy are observed to the function influence of early stage DN rat.
SPF grades of 8 week old male health Wistar rat 132 is selected, after giving normal diet adaptable fed 1 week, with
Machine is divided into two groups: Glycemia Decline group 120, control group 12, fasting 6h, surveys blood glucose.Diabetic nephropathy rats modeling: it gives
High sugar, high lipid food are fed 6 weeks.After 6 weeks, all animal fasting 12h, second day disposable empty stomach abdomen of Glycemia Decline group rat
Chamber injects 50mg/kg streptozotocin (STZ), and blood glucose >=16.7mmol/L is considered as Glycemia Decline success.Hereafter it extracts weekly
Partial rat is put into the urine for 24 hours that diabetes rat is collected in metabolic cage, rat quantity of proteinuria and blank control group difference for 24 hours
Significantly it is considered as DN rat modeling success.
The successful rat of modeling is randomly divided into model control group, Irbesartan group, rhizoma polygonati low dose group, rhizoma polygonati high dose
Group, RS low dose group, RS high dose group, rhizoma polygonati joint RS low dose group and rhizoma polygonati joint RS high dose group and 3 groups of comparative example,
4 groups of comparative example, every group each 12.
Comparative example 3 and 4 group is 12 respectively；Compare 3 groups of 0.25g/kgRS, 1.5g/kg rhizoma polygonati stomach-fillings；In 4 groups of comparative example,
1.5g/kgRS, 0.5g/kg rhizoma polygonati stomach-filling；
Blank control group and model control group give equal dosage physiological saline stomach-filling；
Irbesartan group rat gives 15mg/kg Irbesartan daily；
Rhizoma polygonati low dosage, high dose group are administered by weight of people's mouse dosage 1:20, give 1g/kg, 1.5g/kg respectively daily
Rhizoma polygonati, RS low dosage, high dose group carry out stomach-filling using commercially available amylomaize (Hi-maize 260) suspension, often
Day gives 0.5g/kg, 1g/kg respectively.
Rhizoma polygonati combines RS group on the basis of using the stomach-filling of 1g/kg, 1.5g/kg rhizoma polygonati daily, while use 0.5g/kg,
The RS stomach-filling of 1g/kg, once a day, continuous 4 weeks.Rat is put to death after 4 weeks, collect specimen is tested.Specific experiment result is shown in
Table 16 is to table -21.
From results of animal as can be seen that the fructosamine of experimental early stage DN rat can be significantly reduced in rhizoma polygonati joint RS
(GSP) horizontal, prompt it to have the function of significantly controlling blood glucose.It can be seen that from the data of above table and only contain rhizoma polygonati
Either only contain resistant starch, and the proportion of adjustment rhizoma polygonati and resistant starch with common starch, for hypoglycemic
It acts on much smaller relative to product of the invention.The blood of early stage DN rat is observed in rhizoma polygonati, RS and synergy group
A degree of decline is presented in clear TC and LDL-C level, wherein the effect for reducing fat with rhizoma polygonati is the most significant.Rhizoma polygonati combines RS to morning
The renal function of phase DN rat and tissue damage play certain protective effect, and body inflammatory reaction can be significantly reduced
Level plays anti-inflammatory effect.The combination of both rhizoma polygonati and RS can give full play to respective advantage, and performance is more comprehensively made
With.
As can be seen from Table 16, single rhizoma polygonati group either single resistant starch group all has certain hypoglycemic
Effect, when the two joint, hypoglycemic effect is preferable, but by experiment the inventors discovered that, only matching as rhizoma polygonati and RS
When than within the scope of certain, the rat fructose amine level surveyed is preferable, and compares fasting blood-glucose, and fructosamine can be good
Reflect nearly 2-3 weeks blood glucose level of rat, as a result more stable, more reference significance.As it can be seen that the combination of rhizoma polygonati and RS, the two
It is acted synergistically, so that hypoglycemic effect is more excellent.
The different group experimental rat fructosamines of table 16
| Group | Number of animals (only) | GSP(mmol/L) |
| Blank control group | 12 | 1.16±0.22b |
| Model control group | 12 | 1.92±0.31a |
| Irbesartan group | 12 | 1.77±0.43a |
| Rhizoma polygonati (low) group | 9 | 1.75±0.39a |
| Rhizoma polygonati (height) group | 10 | 1.68±0.39a |
| RS (low) group | 12 | 1.75±0.35a |
| RS (height) group | 11 | 1.97±0.29a |
| Combine (low) group | 11 | 1.72±0.42a |
| Combine (height) group | 12 | 1.52±0.33ab |
| 3 groups of comparative example | 12 | 1.66±0.34ab |
| 4 groups of comparative example | 12 | 1.63±0.34ab |
Note: a P < 0.05 compared with blank control group；B P < 0.05 compared with model control group
Different group experimental rat TC, the TG of table 17
Note: a P < 0.05 compared with blank control group；B P < 0.05 compared with model control group
Different group experimental rat HDL-C, the LDL-C of table 18
| Group | Number of animals (only) | HDL-C(mmol/L) | LDL-C(mmol/L) |
| Blank control group | 12 | 0.73±0.06b | 0.58±0.08 |
| Model control group | 12 | 1.04±0.20a | 0.53±0.12 |
| Irbesartan group | 12 | 0.98±0.12a | 0.50±0.07a |
| Rhizoma polygonati (low) group | 9 | 0.66±0.20b | 0.45±0.08ab |
| Rhizoma polygonati (height) group | 10 | 0.72±0.20b | 0.39±0.07ab |
| RS (low) group | 12 | 1.05±0.08a | 0.46±0.07ab |
| RS (height) group | 11 | 1.06±0.12a | 0.50±0.09a |
| Combine (low) group | 11 | 0.95±0.11a | 0.49±0.10a |
| Combine (height) group | 12 | 0.92±0.22 | 0.53±0.10 |
| 3 groups of comparative example | 12 | 0.94±0.23 | 0.48±0.11a |
| 4 groups of comparative example | 12 | 0.98±0.17a | 0.51±0.09 |
Note: a P < 0.05 compared with blank control group；B P < 0.05 compared with model control group
The different group experimental rat renal function indexs of correlation of table 19
Note: a P < 0.05 compared with blank control group；B P < 0.05 compared with model control group
The different group experimental rats of table 20 quantity of proteinuria index for 24 hours
| Group | Number of animals (only) | Quantity of proteinuria (mg/24h) for 24 hours |
| Blank control group | 4 | 3.05±1.36 |
| Model control group | 4 | 19.52±13.38a |
| Irbesartan group | 4 | 18.48±7.45a |
| Rhizoma polygonati group | 4 | 16.94±12.16a |
| RS group | 4 | 22.31±6.10a |
| Joint group | 4 | 19.04±9.47a |
| 3 groups of comparative example | 4 | 20.12±9.54a |
| 4 groups of comparative example | 4 | 21.85±7.74a |
Note: a P < 0.05 compared with blank control group
The different group experimental rat inflammatory factor indexs of correlation of table 21
Note: a P < 0.05 compared with blank control group；B P < 0.05 compared with model control group
After the intragastric administration on mice that the data in table 16~21 can be seen that in 3 groups and 4 groups of comparative example of the invention, drop
Sugar is nothing like the mouse renal function index in embodiment 1 than, TC, TG value these indexs relevant to renal function；This explanation one
Surely the resistant starch and rhizoma polygonati matched acts synergistically, and can play the role of reducing blood glucose to a certain extent.
Above-described embodiment is only present pre-ferred embodiments, and it is not intended to limit the concept and scope of the present invention, it is all according to
Modification, modification, supplement, substitution, recombination, simplification that scope of the present invention patent is made etc. should all fall into protection model of the invention
It encloses.
Claims (9)
1. the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients, which is characterized in that contain resistant starch in the biscuit
And rhizoma polygonati, resistant starch account for the 4.8~8.9% of biscuit total weight, rhizoma polygonati accounts for the 7.8~13% of biscuit total weight.
2. the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients as described in claim 1, which is characterized in that the cake
Dry is mainly to be prepared by the raw material of following parts by weight:
Weak strength flour 80~120, starch 24~30, peanut oil 34~40, xylitol 12~18, baking powder 3.5~5, rhizoma polygonati 22~
28, egg liquid 9~12, water 25~35；
Wherein in starch containing 58~62% resistant starch.
3. the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients as described in claim 1, which is characterized in that the cake
Primary raw material in dry is as follows:
100 parts of weak strength flour, 28 parts of starch, 36 parts of peanut oil, 15 parts of xylitol, 4 parts of baking powder, 25 parts of rhizoma polygonati, 10 parts of egg liquid,
30 parts of water；
Wherein in starch containing 58~62% resistant starch.
4. the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients as described in claim 1, which is characterized in that rhizoma polygonati
Nine solarization techniques are steamed by nine for wild polygonatum cyrtonema to be prepared, and are purchased from the in good health hall Bioisystech Co., Ltd in Jinan.
5. the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients as claimed in claim 2, which is characterized in that starch
For amylomaize.
6. the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients as claimed in claim 2, which is characterized in that rhizoma polygonati
It is to be cut into volume as 0.25~0.8 cm3Fritter.
7. the preparation method of the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients as claimed in claim 2, including
Following steps:
1) pretreatment of raw material: the wild polygonatum cyrtonema that nine steam nine solarization techniques is broken into block, egg is dispersed as egg liquid, spare；
2) raw material mixes: taking xylitol to be added in peanut oil, sufficiently dismisses dissolution, egg liquid is then added to above-mentioned peanut
In oil, sufficiently dismiss to butyrous, then plus weak strength flour, starch, baking powder, rhizoma polygonati block sequentially add and stir evenly, add
Water pinches into dough；
3) dough microwave ferments: the dough pinched being sealed with preservative film, is handled through microwave small fire, is then stood；
4) Biscuit mold forms: 3) the dough roll marks in is formed；
5) it toasts: preheating in advance, toast, bake to the golden yellow taking-up in biscuit surface；Obtain finished product biscuit.
8. the preparation method of the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients as claimed in claim 7, including
Following steps:
1) pretreatment of raw material: it is 0.25~0.8 cm that the wild polygonatum cyrtonema that nine steam nine solarization techniques, which is broken into volume,3Fritter,
Egg is dispersed as egg liquid, spare；
2) raw material mixes: taking 12~18 parts of xylitols to be added in 34~40 portions of peanut oil, dissolution is sufficiently dismissed, then by 9~12
Part egg liquid is added three times in above-mentioned peanut oil, is sufficiently dismissed to butyrous, is added 80~120 parts of weak strength flours, 24~30
Part starch, 3.5~5 parts of baking powders, 22~28 parts of rhizoma polygonati blocks are sequentially added and are stirred evenly, and are added 25~35 parts of water, are pinched into
Dough；
3) dough microwave ferments: the dough pinched being sealed with preservative film, 15~20s is handled through microwave small fire, then in 3~5
10~15min is stood at DEG C；
4) Biscuit mold forms: 3) the dough roll marks in is formed；
5) toast: oven face fire is adjusted to 160~180 DEG C, and the fire in a stove before fuel is added is adjusted to 140~160 DEG C, 9~12min is preheated in advance, when baking
Between 20~25min, bake to the golden yellow taking-up in biscuit surface；Obtain finished product biscuit.
9. the preparation method of the dedicated high-resistance starch rhizoma polygonati biscuit of Diabetic Nephropathy patients as claimed in claim 8, including
Following steps:
1) pretreatment of raw material: it is 0.25~0.8 cm that the wild polygonatum cyrtonema that nine steam nine solarization techniques, which is broken into volume,3Fritter,
Egg is dispersed as egg liquid, spare；
2) raw material mixes: taking 15 parts of xylitols to be added in 36 portions of peanut oil, sufficiently dismisses dissolution, then by 10 parts of egg liquids point 3
It is secondary to be added in above-mentioned peanut oil, sufficiently dismiss to butyrous, add 100 parts of weak strength flours, 28 parts of starch, 4 parts of baking powders,
25 parts of rhizoma polygonati blocks are sequentially added and are stirred evenly, and are added 30 parts of water, are pinched into dough；
3) dough microwave ferments: the dough pinched being sealed with preservative film, 15~20s is handled through microwave small fire, then at 4 DEG C
Stand 12min；
4) Biscuit mold forms: 3) the dough roll marks in is formed；
5) toast: oven face fire is adjusted to 170 DEG C, and the fire in a stove before fuel is added is adjusted to 150 DEG C, preheats 10min, baking time 23min in advance, bake to
The golden yellow taking-up in biscuit surface；Obtain finished product biscuit.
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