CN109771578A - The composition for preventing and treating diabetes and complication - Google Patents

Abstract

The present invention relates to the compositions of a kind of prevention and treatment diabetes and complication comprising 2~9 parts of component of 3~30 parts of corn stigma, 2~6 parts of American Ginseng, 3~30 parts of Radix Astragali, 2~15 parts of radix rehmanniae recen, 3~15 parts of pueraria lobata, 3~30 parts of Radix Codonopsis, 2~10 parts of mulberry leaf, 1~10 part of radix bupleuri, 0.00002~0.0002 part of trivalent chromium, 1~3 part of water-soluble dietary fiber, 1~15 part of insoluble diedairy fiber, 1~20 part of edible insects component, 2~6 parts of nourishing kidney yin component, 1~5 part of dredging vascellum component and hemostasis；The composition of prevention and treatment diabetes and complication of the invention is mainly by synergistic between above-mentioned each functional component, achieve the purpose that reduce blood glucose, and cost of material is low, is easily obtained, it can also fundamentally adjust nerve, dredging vascellum, bleeding is reduced, body is improved, finally plays the effect of preventing and alleviate various diabetes and its complication.

Description

The composition for preventing and treating diabetes and complication

Technical field

The invention belongs to technical field of traditional Chinese medicine, in particular to the composition of a kind of prevention and treatment diabetes and complication.

Background technique

Diabetes be it is a kind of because of insulin absolutely or it is opposite lack caused by metabolic disease characterized by hyperglycemia, The metabolic disorder etc. of persistent high blood sugar and for a long time fat, protein, Water-Electrolyte etc. can lead to body tissue's organ, especially Eye, kidney, the damage of angiocarpy and nervous system and its dysfunction and failure, serious person can cause dehydration, electrolyte disturbance and The acute complications such as acid-base imbalance ketoacidosis and Hyperosmotic coma.

China's report on Epidemiological in 2010 shows that diabetes mellitus in China illness rate is up to 9.7%, remote high In the average illness rate 6.4% in the whole world, it is even more than the U.S..On the basis of this data, Shanghai Ruijin Hospital and Chinese disease The research team of prevention and control center composition has further tracked diabetes mellitus in China incidence trend in recent years, finds China 18 The disease incidence of year and the above maturity-onset diabetes is up to 11.6%, about 1.139 hundred million people, and 50.1% adult be in diabetes before Phase.This data more illustrates that diabetes have become the great public health problem in China.

With the extension of diabetic duration, according to the data in " Type 2 Diabetes In China guideline of prevention and treatment ", all kinds of concurrent Nervous system lesion disease incidence highest among disease, has reached 46%, and wherein pathogenesis of diabetic retinopathy rate is up to 30%. Therefore, in the treatment method of diabetes, it cannot only focus on hypoglycemic, more to prevent and treat diabetic complication.

Theory of traditional Chinese medical science thinks: the characteristic of disease feature of diabetes is asthenia in origin and asthenia in superficiality, this void is the internal organs such as spleen, lung, the heart, kidney, liver void Based on weak and negative and positive of qi and blood body fluid loss；The domination of pathogen is then built up with the pathological products such as phlegm wet, scorching, extravasated blood internal.It is weakened body resistance it In, and with spleen deficiency for this.In general, be mostly disease sheet with the dysfunction of the spleen in transport, the deficiency of vital energy in diabetes mellitus, and dryness-heat being excessive in the interior, disappear Burn mark of the body fluid with trough for disease；It is scorching not remove if the state of an illness further develops, saliva hurt with the passing of time, gas is consumed with saliva, spleen deficiency more very, then Form deficiency of both qi and yin disease；Deficiency of both qi and yin further develops, until the diabetes later period, then saliva stops blood resistance, raw, phlegm in phlegm blood to the deficiency of vital energy The pathological products such as wet, extravasated blood become in succession cures the disease originally.

Currently, the drug for the treatment of diabetes can be divided into Chinese medicine and two kinds of Western medicine.Western medicine mainly passes through stimulation islet secretion Insulin, to supplement the deficiency of own insulin；Or by preventing enteron aisle from reducing blood glucose to the absorption of sugar.Common drug There are biguanides, sulfamido, meglitinide and insuline pro injection, these Western medicine are to reach control and temporarily working The purpose of blood glucose needs lifelong medication, and has the side effects such as certain digestive tract reaction and damage liver, kidney after taking.And it is normal Some Chinese materia medica preparations, such as ginseng-astragalus blood-sugar lowering, hypoglycemic are promoted blood circulation, disappear sugared spirit, although reducing the side effect of Western medicine, by Simple in compatibility, in terms of hypoglycemic the effect of, is not strong, and cannot effectively prevent the generation of complication and further deteriorate.

Summary of the invention

In order to overcome, existing antihypelipidemic product side effect is big, dependence is strong, hypoglycemic effect is bad and does not focus on to complication The problems such as prevention and treatment, the present invention provides the compositions of a kind of prevention and treatment diabetes and complication, can inhibit blood glucose plain from the root Secretion, increases blood vessel elasticity at the infiltration rate for reducing glucose, improves blood circulation, diabetes are effectively relieved in recuperating qi-blood And its complication.

The technical scheme adopted by the invention is that:

A kind of composition for preventing and treating diabetes and complication, including 3~30 parts of corn stigma, 2~6 parts of American Ginseng, Huang 3~30 parts of stilbene, 2~15 parts of radix rehmanniae recen, 3~15 parts of pueraria lobata, 3~30 parts of Radix Codonopsis, 2~10 parts of mulberry leaf, 1~10 part of radix bupleuri, trivalent 0.00002~0.0002 part of chromium, 1~3 part of water-soluble dietary fiber, 1~15 part of insoluble diedairy fiber, edible insects group 2~9 parts of component of point 1~20 part, 2~6 parts of nourishing kidney yin component, 1~5 part of dredging vascellum component and hemostasis.

It further limits, the composition also includes to increase by 1~3 part of blood vessel elasticity component, can be by increasing blood vessel bullet Property, improve blood circulation, keep blood smooth, improve sugar and utilize transformation efficiency, to reduce blood glucose, and is effectively prevented glycosuria The occurrence and development of sick complication.

It further limits, the increase blood vessel elasticity group is divided into lecithin, deep sea fish oil, black fungus, garlic, onion, west It is red persimmon, apple, nut, hawthorn, green tea, Semen sesami nigrum, kelp, eggplant, corn, jujube, carrot, grape wine, any in vinegar A kind of or any combination.

It further limits, further includes neurotrophy component: 0.1~0.5 part, can prevent and alleviate caused by diabetes Various nervous system lesions；The neurotrophy component includes phosphatidylserine, arachidonic acid oil, fish oil and extraction Object, γ-aminobutyric acid (GABA), any one or any combination in phosphatide.

It further limits, the trivalent chromium includes any one in Organic Chromium and inorganic chromium or any combination, described organic Chromium includes animal's liver, Cr-enriched yeast, nicotinate chromium, and the inorganic chromium includes chromium sulfate and/or chromium trichloride.

Further limit, the water-soluble dietary fiber include resistant dextrin, konjaku flour, xylo-oligosaccharide, oligofructose, Inulin, polydextrose, stachyose, oligoisomaltose, isomaltoketose, any one in chitosan or any combination；It is described Insoluble diedairy fiber includes Cillium, Herba bromi japonici dietary fiber, quinoa dietary fiber, wheat bran dietary fiber, buckwheat meals It eats fiber, barley seedling powder, mushroom powder, celery powder, spinach powder, broccoli powder, hedgehog hydnum mushroom powder, any one in apple powder or appoints Meaning combination.

Further limit, edible insects group be selected from bamboo worm, sandworm, ant egg, locust, bavin worm, willow worm, chrysalis, Chrysalis, bee pupa, ant, honeybee, greenish brown hawk moth, yellow meal worm, any one in Asiatic migrotory locust adult or any combination.

It further limits, the nourishing kidney yin group is selected from tortoise meat, pigeon meat, perch, dog meats, dried scallop, cicada, animal kidney Dirty, Rehmannia glutinosa, mulberries, tortoiseshell, fructus lycii, Schisandra chinensis, Chinese yam, Semen Cuscutae, oyster, Gorgon fruit, any one in the fleece-flower root are appointed Meaning combination.

The dredging vascellum component includes Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Gastrodiae, Radix Notoginseng, hawthorn, peach kernel, safflower, Radix Angelicae Sinensis, radix paeoniae rubra, Pu Huang, olibanum, myrrh, rhizoma corydalis, curcuma zedoary, any one or any combination in Herba Lycopi；

The hemostasis component include crinis trachycarpi, charred NODUS NELUMBINIS RHIZOMATIS, charred RADIX ANGELICAE SINENSIS, charred RADIX RUBIAE, charred HERBA CIRSII JAPONICI, charred RHIZOMA OSMUNDAE SEU DRYOPTERIS CRASSIRHICOMAE, rhizoma imperatae charcoal, Red crowned crane turf, bletilla, carbonized hair, folium callicarpae pedunculatae, Loropetalum wood, clinopodium polycephalum, any one in cockscomb or any combination.

The composition of above-mentioned prevention and treatment diabetes and complication treat and alleviate the drugs of diabetes, health food or Application in terms of functional food.

The composition of above-mentioned prevention and treatment diabetes and complication is alleviating diabetes complicated disease drug, health food or function Application in terms of energy food.The composition of prevention and treatment diabetes and complication of the invention, mainly includes following functions ingredient:

Corn stigma: sweet and neutral, it is sweet in flavor；Return bladder, liver, gallbladder channel.Diuresis expels the heat-evil, calming the liver, cholagogue, can reduce blood glucose, is applicable in It is assisted in the treatment of in diabetic.Saponin is the main component for reducing diabetes patient blood sugar in corn stigma；In addition in corn stigma Also contain chromium, the function of insulin can be reinforced；Flavonoid substances have good oxidation resistance in corn stigma, can be pre- Anti- diabetic complication.

American Ginseng: sweet, slight bitter, it is cool；Return heart, lung, kidney channel.Boosting qi and nourishing yin, clearing heat and promoting fluid.American Ginseng by protection and it is extensive Multiple beta Cell of islet, increases the various ways such as insulin sensitivity, promotes the secretion of insulin, achievees the purpose that reduce blood glucose.

Radix Astragali: sweet, tepor；Return lung, the spleen channel.Tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, shengjin nourishing, move stagnation and palsy, Pus draining and toxin expelling, expelling pus and promoting granulation.Radix Astragali can increase insulin sensitivity, improve insulin resistance；Beta Cell of islet is protected, pancreas is promoted The release of island element；The purpose for reducing blood glucose is played by the effect that immunological regulation increases pancreas beta cell new life etc.；Another party Face can also prevent and treat the complication such as diabetic retina, cardiovascular and cerebrovascular and renal lesions.

Radix rehmanniae recen: it is sweet, it trembles with fear；Return heart, liver and kidney channel.The hot cool blood of Cheongju, nourishing Yin and promoting production of body fluid.Modern pharmacological studies have shown that radix rehmanniae recen With islet beta cell function is improved, reduces blood insulin and resist level, adjust grape cell sugar Equilibrium, reduce liver grape Sugar -6- phosphatase activity, improve disorders of lipid metabolism, improve renal function the effects of, can effectively prevent and treat diabetes and its Complication.

Pueraria lobata: it is sweet, pungent, it is cool；Returns spleen, stomach, lung channel.Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid to quench thirst, promoting eruption, Shengyang Zhixie, clearing and activating the channels and collaterals, Relieving alcoholism.Modern pharmacological studies have shown that pueraria lobata can improve insulin resistance, increase the sensibility of insulin, passes through the anti-of pueraria lobata Oxidative stress can play the role of protecting cardiac muscle, kidney, avoid diabetic complication.

Radix Codonopsis: sweet and neutral；Returns spleen, lung channel；Strengthening spleen and tonifying lung, nourishes blood and promotes the production of body fluid.Modern pharmacological studies have shown that Radix Codonopsis can be significant Blood glucose in diabetic mice is reduced, adjusts diabetic mice blood lipid metabolism, always gluconeogenesis, promotes Glycogen synthesis, improves insulin It resists.

Mulberry leaf: it is sweet, bitter, it trembles with fear；Return lung, Liver Channel.Dispelling wind and heat from the body, clearing away the lungheat and moisturizing are clear liver and improved vision.Contain a kind of spy in mulberry leaf Different blood sugar reducing component --- 1-DNJ is potent alpha-glucosidase inhibitor, can prevent polysaccharide conversion in food For the monosaccharide easily absorbed, the producing level of sugar is reduced；Polysaccharose substance in mulberry leaf may act on beta Cell of islet, improve Insulin secretion promotes body to utilize the metabolism of glucose, and both the above functional component plays hypoglycemic, control after the meal jointly The purpose of blood glucose.

Radix bupleuri: it is pungent, bitter, it is slightly cold；Return liver, gallbladder, lung channel.Evacuation is brought down a fever, soothing liver-qi stagnation, lifting disease.Radix bupleuri can discongest Liver depression, evacuation are scorching, have preferable adjuvant treatment effect to diabetes caused by depressed liver and heat transmission.

Trivalent chromium: chromium is the constituent of glucose tolerance factor (GTF), is that a kind of water-soluble low molecule is matched containing chromium Position object, is made of chromium and niacin, and physiological activity and chromium content have parallel relation.It can make glucose tolerance after chromium deficiency It reduces, leads to the generation of hyperglycemia.

Dietary fiber component: water-soluble dietary fiber can delay gastric emptying, and a kind of mucous membrane is formed in stomach and intestine, can extend Food residence time in the intestine, the infiltration rate for reducing glucose, makes to steeply rise into postprandial blood sugar, be conducive to sugar Urinate the improvement of the sick state of an illness；Water-soluble dietary fiber also has the function of inhibiting the secretion of blood glucose element simultaneously.Insoluble diedairy fiber Gastric emptying can be slowed down, so that body is delayed and reduces to the absorption of glucose, to play balance and stabilizing blood sugar level Effect.

Nourishing kidney yin component: the kidney being the origin of congenital constitution, main store essential substances and nephroyin and nephroyang of residing, and kidney-yin deficiency is the origin of YIN fluid deficiency, Insufficiency of natural endowment is the Basic disease cause of diabetes.

Edible insects component: contain protein (such as fibroin albumen, sericin, Ant Protein) and proteolysis Afterwards component polypeptides, polysaccharide (such as glycogen, chitin, glycosaminoglycan, acid mucopolysaccharide), unsaturated fatty acid (such as linolenic acid, Linoleic acid), alkaloid (such as 1- deoxidation nojirimycin), flavones, hormone (ecdysterone, thyroid hormone analogs triiodo first gland Former propylhomoserin, sbombycin), nucleosides material (such as cordycepin), microelement (chromium, manganese, zinc, calcium, iron, copper, selenium) and vitamin Blood-sugar decreasing actives such as (vitamin Ds).

Dredging vascellum component: it becomes silted up through in diabetes and complication morbidity whole process, the defeated cloth of the unobstructed body fluid of blood is then Scorching to solve, the stasis of blood is stagnant, and must to change the unobstructed then yin-fluid of mechanism of qi spontaneous.

Hemostasis component: the clotting time can be shortened, and increase platelet count, diabetic complication is can be widely used for and such as disappear Change gastrointestinal hemorrhage, hemorrhage in respiratory tract, fundus hemorrhage, diabetes, wound face healing difficulty etc..

The composition of prevention and treatment diabetes and complication of the invention is mainly increased by cooperateing between above-mentioned each functional component Effect is equipped with heat-clearing except dry mulberry leaf, radix bupleuri, radix rehmanniae recen using civil common corn stigma as main component, boosting qi and nourishing yin Radix Astragali, American Ginseng, tonifying spleen and stopping diarrhea, the Radix Codonopsis to promote the production of body fluid to quench thirst, pueraria lobata, while being aided with activating microcirculation and removing stasis medicinal, nourishing kidney yin ingredient and new Functional food raw material trivalent chromium, dietary fiber etc. achieve the purpose that reduce blood glucose, and cost of material is low, is easily obtained, furthermore It is additionally added edible insects, hemostasis, increases the novel substances such as blood vessel elasticity, neurotrophy, nutritional support is provided, is fundamentally adjusted Section nerve, dredging vascellum reduce bleeding, improve body, and finally playing prevents and alleviate various diabetes and its complication Effect.

Specific embodiment

Technical solution of the present invention is further described now in conjunction with embodiment and experiment, but the present invention not only limits In following implementation situations.

The composition of prevention and treatment diabetes and complication of the invention mainly includes 3~30 parts of corn stigma, the West Join 2~6 parts, 3~30 parts of Radix Astragali, 2~15 parts of radix rehmanniae recen, 3~15 parts of pueraria lobata, 3~30 parts of Radix Codonopsis, 2~10 parts of mulberry leaf, radix bupleuri 1 ~10 parts, 0.00002~0.0002 part of trivalent chromium, 1~3 part of water-soluble dietary fiber, 1~15 part of insoluble diedairy fiber, mind Through nutrition composition: 0.1~0.5 part, 1~20 part of edible insects component, 2~6 parts of nourishing kidney yin component, dredging vascellum component 1 ~5 parts, 1~3 part of blood vessel elasticity component of increase, 2~9 parts of component of hemostasis.

Trivalent chromium can in Organic Chromium or inorganic chromium any one or a few, Organic Chromium can selected from animal's liver, Cr-enriched yeast, nicotinate chromium etc.；Inorganic chromium can be selected from chromium sulfate, chromium trichloride etc..

Water-soluble dietary fiber can be selected from resistant dextrin, konjaku flour, xylo-oligosaccharide, oligofructose, inulin, poly- grape Any one or any combination such as sugar, stachyose, oligoisomaltose, isomaltoketose and chitosan；Insoluble diet is fine Dimension can selected from Cillium, Herba bromi japonici dietary fiber, quinoa dietary fiber, wheat bran dietary fiber, buckwheat dietary fibers, Any one or any group such as barley seedling powder, mushroom powder, celery powder, spinach powder, broccoli powder, hedgehog hydnum mushroom powder and apple powder It closes.

Neurotrophy component can be selected from phosphatidylserine, arachidonic acid oil, fish oil and extract, gamma-amino Butyric acid (GABA), phosphatide etc..

Edible insects component can be selected from bamboo worm, sandworm, ant egg, locust, bavin worm, willow worm, chrysalis, chrysalis, bee Pupa, ant, honeybee, greenish brown hawk moth, yellow meal worm, Asiatic migrotory locust adult etc..

Nourishing kidney yin component can be selected from tortoise meat, pigeon meat, perch, dog meats, dried scallop, cicada, animal kidney, Rehmannia glutinosa, mulberry Shen, tortoiseshell, fructus lycii, Schisandra chinensis, Chinese yam, Semen Cuscutae, oyster, Gorgon fruit, fleece-flower root etc., in addition to traditional Chinese medicine, other animals The raw material in the sources such as insect is added in dry powder form.

Dredging vascellum component can be selected from Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Gastrodiae, Radix Notoginseng, hawthorn, peach kernel, safflower, Radix Angelicae Sinensis, radix paeoniae rubra, Pu Huang, olibanum, myrrh, rhizoma corydalis, curcuma zedoary, Herba Lycopi etc..

Lecithin, deep sea fish oil, black fungus, garlic, onion, tomato, apple can be selected from by increasing blood vessel elasticity component Fruit, nut, hawthorn, green tea, Semen sesami nigrum, kelp, eggplant, corn, jujube, carrot, grape wine, vinegar etc..

Stop blooding component can selected from crinis trachycarpi, charred NODUS NELUMBINIS RHIZOMATIS, charred RADIX ANGELICAE SINENSIS, charred RADIX RUBIAE, charred HERBA CIRSII JAPONICI, charred RHIZOMA OSMUNDAE SEU DRYOPTERIS CRASSIRHICOMAE, rhizoma imperatae charcoal, Red crowned crane turf, bletilla, carbonized hair, folium callicarpae pedunculatae, Loropetalum wood, clinopodium polycephalum, cockscomb etc..

Capsule, tablet, particle can be made in the composition of prevention and treatment diabetes and complication of the invention according to common process Agent, tea beverage and biscuit etc..

Embodiment one

(1) corn stigma 7g, American Ginseng 2g, Radix Astragali 5g, radix rehmanniae recen 6g, pueraria lobata 5g, Radix Codonopsis 3g, mulberry leaf 6g, radix bupleuri 3g, five Taste 5g, crinis trachycarpi 3g, Radix Salviae Miltiorrhizae 5g add 12 times of water to impregnate 1.5 hours, decoct 2 times, extract 2 hours every time, decoct every time After separate medical fluid, filter, merging decocts filtrate twice, point takes supernatant after static；

(2) relative density is when (- 0.06MPa, temperature be 55 DEG C) is concentrated under reduced pressure to 50 DEG C in obtained supernatant 1.22, the ethyl alcohol that 2.5 times of volumetric concentrations of relative enhancement liquid quality are 95% is added into concentrate, is sufficiently stirred, stands 48h Filtration obtains filtrate, the ethanol washing that dregs of a decoction volumetric concentration is 60%, and washing lotion merges with filtrate, be concentrated under reduced pressure (- 0.06MPa, Temperature is 55 DEG C) to 50 DEG C when relative density be 1.35 clear cream；Clear cream is dried under reduced pressure (- 0.085Mpa, 60 DEG C), is crushed to Dried cream powder.Be added bamboo worm dry powder 2g, chrysalis dry powder 1g, perch dry powder 1g, Cr-enriched yeast 0.1g, resistant dextrin 1g, lecithin 1g, Phosphatidylserine 0.4g, Cillium 1g are mixed, and cross 80 meshes, and 60% (w/w) alcohol granulation is added；It is wet by what is made 55 DEG C of dryings of particle are to moisture 5% hereinafter, whole grain, obtains dry particl, loading capsule (1g/) is to get finished product.

Embodiment two

(1) corn stigma 8g, American Ginseng 3g, Radix Astragali 3g, radix rehmanniae recen 3g, pueraria lobata 3g, Radix Codonopsis 5g, mulberry leaf 3g, radix bupleuri 3g, Chinese holly Matrimony vine 3g, Schisandra chinensis 3g, red crowned crane turf 3g, bletilla 2g, Rhizoma Chuanxiong 3g add 12 times of water to impregnate 2 hours, decoct 2 times, mention every time It takes 2 hours, separates medical fluid after decocting every time, filter, merging decocts filtrate twice, and static rear point takes supernatant；

(2) relative density is when (- 0.07MPa, temperature be 60 DEG C) is concentrated under reduced pressure to 50 DEG C in obtained supernatant 1.22, the ethyl alcohol that 3 times of volumetric concentrations of relative enhancement liquid quality are 95% is added into concentrate, is sufficiently stirred, it is (quiet after standing Set time 48h) filtration, filtrate, the ethanol washing that dregs of a decoction volumetric concentration is 60% are obtained, washing lotion merges with filtrate, is concentrated under reduced pressure The clear cream that relative density is 1.35 when (- 0.07MPa, temperature are 60 DEG C) is to 50 DEG C；Clear cream be dried under reduced pressure (- 0.085Mpa, 60 DEG C), it is crushed to dried cream powder.Ant egg dry powder 4g, chromium trichloride 0.0001g, xylo-oligosaccharide 1g, apple powder 2g, fish oil is added And extract 0.5g, it mixes, crosses 80 meshes, the sodium carboxymethylcellulose of total silty amount 1% and 2% carboxymethyl starch is added Sodium is uniformly mixed, and 60% (w/w) alcohol granulation is added；By the 55 DEG C of dryings of wet granular made to moisture 5% hereinafter, whole grain, Obtain dry particl；Be added dry particl total amount 1% magnesium stearate, mixing, obtain total mixture through tabletting be made tablet (1g/ piece, daily 3 It is secondary, one time 4).

Embodiment three

(1) corn stigma 6g, American Ginseng 3g, Radix Astragali 4g, radix rehmanniae recen 5g, pueraria lobata 6g, Radix Codonopsis 3g, mulberry leaf 6g, radix bupleuri 3g, Tu The sub- 3g of silk, clinopodium polycephalum 5g, safflower 3g, Radix Angelicae Sinensis 2g, add 12 times of water to impregnate 2 hours, decoct 2 times, every time extraction 2 hours, every time Medical fluid is separated after decoction, is filtered, and merging decocts filtrate twice, divides after static and takes supernatant；

(2) relative density is when (- 0.06MPa, temperature be 55 DEG C) is concentrated under reduced pressure to 50 DEG C in obtained supernatant 1.22, the ethyl alcohol that 3 times of volumetric concentrations of relative enhancement liquid quality are 95% is added into concentrate, is sufficiently stirred, it is (quiet after standing Set time 36h) filtration, filtrate, the ethanol washing that dregs of a decoction volumetric concentration is 60% are obtained, washing lotion merges with filtrate, is concentrated under reduced pressure (- 0.06MPa, temperature are 55 DEG C) removes ethyl alcohol, grape wine 15g is added, uniform medical fluid is made in stirring, homogeneous.

(3) the uniform medical fluid that will be obtained, relative density is when (- 0.06MPa, temperature be 55 DEG C) is concentrated under reduced pressure to 50 DEG C 1.35 clear cream；Clear cream is dried under reduced pressure (- 0.085Mpa, 55~70 DEG C), is crushed to dried cream powder, and chromium sulfate 0.004g, phosphorus is added Acyl serine 0.5g, bavin worm dry powder 3g, dry ant powder 3g, animal kidney dry powder 3g, quinoa dietary fiber 1g are uniformly mixed, 80 meshes are crossed, it is spare.Dry powder, resistant dextrin 3g after mixing are uniformly mixed, pelletized with 14 meshes, 55-60 DEG C of drying, 12,20 The double screening grains of mesh, dispense, examine, and packaging is to get finished product (every bag of 6g, 3 times a day, 1 bag every time).

Example IV

Step (1): following raw material: corn stigma 6g, American Ginseng 4g, Radix Astragali 5g, radix rehmanniae recen is weighed respectively by quality proportioning 3g, pueraria lobata 5g, Radix Codonopsis 3g, mulberry leaf 8g, radix bupleuri 5g, resistant dextrin 2g, isapgol husk 3g, yellow meal worm 12g, Asiatic migrotory locust adult 5g, tortoiseshell 2g, curcuma zedoary 3g, hawthorn 2.5g, carbonized hair 2g.

Step (2): 12 times of total mass of raw material of water being added into step (1) weighed raw material, filters after decocting 2 hours, 8 times of total mass of raw material of water is added into filter residue, is filtered after decocting 2 hours, merges the filtrate decocted twice；

Step (3): the liquid pectin of filtrate gross mass 0.03% is added in the filtrate decocted twice to step (2) Enzyme digests heat boiling 10min enzyme deactivation after 6h, and liquid to be filtered is cooled to room temperature, clarifying agent is added and stirs evenly, clarifying agent ZTC1+1 Natural clarifying agent, component A, B component additional amount are the 1.5% of filtrate gross mass, are filtered to remove precipitating after standing 40min, Clarification medical fluid after being digested；

Step (4): (- 0.06MPa, temperature are 55 DEG C) is concentrated under reduced pressure extremely in the clarification medical fluid that step (3) is obtained 500ml is added nicotinate chromium 0.0015g, chitosan 3g, arachidonic acid oil 0.5g etc., stirs evenly, refined filtration is up to tea-drinking Material.

Embodiment five

Step (1): corn stigma 25g, American Ginseng 3g, Radix Astragali 3g, radix rehmanniae recen 10g, pueraria lobata 5g, Radix Codonopsis 4g, mulberry leaf are weighed 12 times of total mass of raw material of water is added into above-mentioned raw materials, it is small to decoct 2 by 5g, radix bupleuri 5g, Gorgon fruit 3g, charred RHIZOMA OSMUNDAE SEU DRYOPTERIS CRASSIRHICOMAE 5g, curcuma zedoary 3g When after filter, 8 times of total mass of raw material of water is added into filter residue, is filtered after decocting 2 hours, merges the filter decocted twice Liquid is concentrated under reduced pressure into every milliliter of medical fluid 1g containing crude drug to get medical fluid extract.

Step (2): Semen sesami nigrum 2g, ant 3g, honeybee 2g, corn 1g are crushed respectively, are sieved with 100 mesh sieve；

Step (3): by the extract and black sesame powder, corn flour, ant powder, honeybee powder and tri-chlorination in step (1) Chromium 0.0006g, polydextrose 3g, quinoa dietary fiber 5g, wheat bran dietary fiber 5g, buckwheat dietary fibers 5g, phosphatide The mixing such as 0.3g, wholewheat flour 100g, stirs evenly, and 5~10% water and face is added, stands 10 minutes, after compression moulding, 20~22 minutes are toasted at 150~180 DEG C of temperature to get glucose-lowering biscuit.

Embodiment six

It is with the raw material proportioning of the present embodiment is in place of the difference of above-described embodiment one:

Corn stigma 6g, American Ginseng 3g, Radix Astragali 6g, radix rehmanniae recen 3g, pueraria lobata 4g, Radix Codonopsis 3g, mulberry leaf 6g, radix bupleuri 1g, chromium sulfate 80 μ g, oligoisomaltose 2g, xylo-oligosaccharide 1g, mushroom powder 5g, broccoli powder 1g, arachidonic acid oil 0.3g, locust powder 1g, bavin worm powder 0.5g, tortoise digested tankage 1g, pigeon meat powder 1g, peach kernel 1g, safflower 1g, Radix Angelicae Sinensis 2g, olibanum 1g and charred RADIX RUBIAE 2g, cockscomb Flower 1g.

Embodiment seven

It is with the raw material proportioning of the present embodiment is in place of the difference of above-described embodiment five:

Corn stigma 5g, American Ginseng 2g, Radix Astragali 5g, radix rehmanniae recen 4g, pueraria lobata 5g, Radix Codonopsis 4g, mulberry leaf 7g, radix bupleuri 1g, chromium sulfate 200 μ g, konjaku flour 1g, stachyose 2g, celery powder 1g, spinach powder 1g, γ-aminobutyric acid 0.4g, willow worm powder 2g, chrysalis powder 3g, honeybee powder 2g, dog meats powder 1g, dried scallop powder 1g, cicada powder 2g, fleece-flower root 1g, Semen Cuscutae 1g, radix paeoniae rubra 2g, cattail pollen 3g, black wood Ear 1g, garlic 1g, onion 1g, Loropetalum wood 2g, charred NODUS NELUMBINIS RHIZOMATIS 3g, charred RADIX ANGELICAE SINENSIS 3g.

Embodiment eight

It is with the raw material proportioning of the present embodiment is in place of the difference of above-described embodiment three:

Corn stigma 20g, American Ginseng 6g, Radix Astragali 15g, radix rehmanniae recen 15g, pueraria lobata 15g, Radix Codonopsis 6g, mulberry leaf 2g, radix bupleuri 10g, 100 μ g of nicotinate chromium, oligofructose 1g, inulin 2g, barley seedling powder 3g, phosphatidase 0 .2g, sandworm powder 1g, ant powder 0.5g, greenish brown hawk moth Powder 0.5g, yellow meal worm powder 0.2g, chrysalis powder 1g, Asiatic migrotory locust adult powder 4g, sheep kidney powder 0.5g, fructus lycii 2g, oyster 0.5g, Green tea 1g, charred HERBA CIRSII JAPONICI 3g, charred RHIZOMA OSMUNDAE SEU DRYOPTERIS CRASSIRHICOMAE 3g, rhizoma imperatae charcoal 3g, myrrh 2g.

Embodiment nine

It is with the raw material proportioning of the present embodiment is in place of the difference of above-described embodiment two:

Corn stigma 20g, American Ginseng 6g, Radix Astragali 15g, radix rehmanniae recen 15g, pueraria lobata 15g, Radix Codonopsis 6g, mulberry leaf 2g, radix bupleuri 10g, 20 μ g of foie gras powder (presses Cr³⁺Quality meter), stachyose 1g, isomaltoketose 0.3g, Herba bromi japonici dietary fiber 2g, broccoli powder 1g, Cillium 1g, γ-aminobutyric acid (GABA) 0.1g, bee pupa powder 3g, Chinese yam 2g, Rehmannia glutinosa 1g, Semen Cuscutae 1g, Gorgon fruit 1g, Rhizoma corydalis 0.5g, curcuma zedoary 0.5g, Herba Lycopi 1g, carbonized hair 1g, folium callicarpae pedunculatae 2g, hawthorn 1g, green tea 2g.

Embodiment ten

It is with the raw material proportioning of the present embodiment is in place of the difference of above-described embodiment four:

Corn stigma 15g, American Ginseng 4g, Radix Astragali 12g, radix rehmanniae recen 9g, pueraria lobata 9g, Radix Codonopsis 20g, mulberry leaf 2g, radix bupleuri 5g, richness 200 μ g of chromium yeast, chitosan 1g, hedgehog hydnum mushroom powder 1g, fish oil and extract 0.5g, locust powder 3g, mulberries 4g, Semen Cuscutae 1g, when Return 1g, Rhizoma Chuanxiong 1g, vinegar 1g, cockscomb 3g.

In order to verify prevention and treatment diabetes and complication of the invention composition hypoglycemic effect, now with it is following experiment be Example is illustrated.

Test example one

1, case selection: selection 80 carry out clinical sight through the more stable adult type 2 diabetic patient of the diet control state of an illness Test is examined, clinical symptoms are polydipsia, mostly food gluttony, and body is thin, and urinary micturition, the dizzy soreness of waist, two legs are out of strength, on an empty stomach Blood glucose >=8.3mmol/L or 2h-plasma glucose >=11.1mmol/L.

2, treatment method: it is for oral administration using the product of the embodiment of the present invention one, three times a day, daily four, take before the meal, 4 weeks It is as a treatment course.During treatment phase and treatment, blood glucose, body temperature, blood pressure, pulse, cardiac function are detected.Other drugs are not taken, It is careful in one's diet, appropriate exercise.

3, observation of curative effect: therapeutic evaluation mark is formulated by " guideline of clinical investigations of new Chinese medicine treatment diabetes " It is quasi-.It is effective to disappear for symptom, fasting blood-glucose < 7.0mmol/L, 2h-plasma glucose < 8.3mmol/L；Effectively obviously change for symptom It is kind, fasting blood-glucose < 8.3mmol/L, 2h-plasma glucose < 10.0mmol/L；Symptom is not improved before and after futile treatment, blood Sugar does not reach above-mentioned standard.

The results are shown in Table 1 for observation:

Table 1 is hypoglycemic effect of the composition in clinical trial of prevention and treatment diabetes and complication of the invention

4, conclusion: this clinical test results shows that Jiangtang capsule of the present invention controls type 2 diabetic patient Treating total effective rate is 92.50%.Before and after treatment, every physical signs such as the enquirement of patient, blood pressure, heart has no adverse reaction, It can illustrate that this product has no toxic side effect, capsule dosage form facilitates patient to take, and can be widely applied to clinical treatment.

Test example two

Health food is made in the composition of prevention and treatment diabetes and complication of the invention, and has carried out human experiment and moved Object experiment.

(1) human feeding trial is reported

Tested material: the composition of prevention and treatment diabetes and complication of the invention.

Study subject:

The state of an illness is more stable after diet control or oral hypoglycemic agents treatment, does not need replacement types of drugs and dosage, only takes With the adult diabetes B patient of maintenance dose, empty stomach >=7.8mmol/L (140mg/dl) and 2h-plasma glucose >=11.1mmol/ L(200mg/dl)；Also can choose 7.8mmol/L >=fasting blood-glucose >=6.7mmol/L (120mg/dl) and 11.1mmol/L >= 2h-plasma glucose >=7.8mmol/L hyperglycemia population.

Eliminator's standard:

Age is in under-18s or over-65s person, pregnant or breast feeding women.

There are the complication such as severe cardiac, liver, kidney, or is associated with other severe primary diseases, mental patient.

Loner, data do not judge effect person completely without method.

Experimental design and test-meal method: 114 subjects are randomly divided into test-meal group and control group, using own control with Control design between two groups.Examination trencherman's original takes hypoglycemic medicine kind and believes that dosage is constant, and test-meal group adds the food embodiment of the present invention three Granule, control group take placebo granulation, are 1 bag every time, 3 times a day.It is required that examination trencherman adheres to diet control for a long time, It is fed by different labor intensity and figure.

Instrument and reagent: F-20 type blood counting instrument, MIDIRON urinate ten analyzers (Germany produces), and RA1000 is full-automatic Biochemical Analyzer (U.S.'s production), biochemical reagents box is all provided by Zhong Sheng company.

1, observation index: indices in test-meal test start and at the end of respectively test it is primary, test-meal the 15th day plus survey empty Abdomen blood glucose is primary.

2, efficiency observation:

Detailed medical history-taking, understanding subject's diet situation, activity observe main clinic symptoms: more foods are drunk more, are weary Power etc..Integrated value is counted before and after test-meal by symptom weight (severe 3 is divided, and moderate 2 is divided, and mild 1 is divided), and its symptom is improved (each 2 points of symptom improvement effective, and it is effective for improving 1 point), calculates improvement rate.

Fasting blood-glucose and postprandial 2 hours blood sugar tests

The detection of glucose in urine urine ketone bodies

Blood lipid (total cholesterol TC, triglycerides TG, high-density lipoprotein cholesterol HDL-C) detects 3, safety indexes:

General status: spirit, appetite, sleep, stool and urine, heart rate, blood pressure etc..

Urine, routine urinalysis, just routine inspection

Red blood cell count(RBC), hemoglobin, white blood cell count(WBC), routine urinalysis, just routine inspection.

Biochemical Indexes

Seralbumin ALB, total protein TP, darling renal function (glutamic-oxalacetic transaminease AST, glutamic-pyruvic transaminase ALT, urea UREA, creatinine CRE)

Abdominal B-scan ultrasonography, electrocardiogram, x-ray fluoroscopy of chest

Adverse reaction observation

Data processing: calculating analysis data with statistical software STATE6.0, and all own control data use paired t-test, Two groups of means compare using independent samples t-test, behind need carry out homogeneity test of variance, to the number of Non-Gaussian Distribution or heterogeneity of variance T inspection is carried out with the data of conversion after meeting normal state homogeneity of variance according to variable conversion appropriate is carried out；If change data is still It is not able to satisfy normal state homogeneity of variance requirement, uses t ' inspection or rank sum test instead；But the coefficient of variation is too as large as the money of (CV > 50%) Material applies rank sum test.Efficacy measures X²It examines.

4, effect criterion

Effective: empty stomach or postprandial 2 hours blood glucose are compared with decline >=10% before test-meal, test-meal front and back itself after test-meal group test-meal Comparing difference has conspicuousness.Test-meal group and control group blood glucose value and blood glucose decline two group difference of percentage have conspicuousness.

Invalid: blood glucose decline is not up to above-mentioned standard

5, test result

Ordinary circumstance compares before 5.1 two groups of observations

Ordinary circumstance compares before table 1 is observed

100 are observed altogether, and ordinary circumstance is normal.

Table 2 tries trencherman and takes hypoglycemic medicine situation

By table 1, table 2 as it can be seen that each index no significant difference before two groups of test-meals, is comparable.

5.2 safety observations indexs

Changes in heart rate before and after 3 test-meal of table

Blood pressure before and after 4 test-meal of table

The variation of 5 safety indexes of table is compared

After two groups of test-meals, blood pressure, heart rate, blood, urine (except glucose in urine), just conventional, blood biochemistry detects indices without obvious Variation.

The inspections such as the electrocardiogram, fluoroscopy of chest of two groups of subjects and abdominal B-scan ultrasonography are showed no exception before test-meal.

5.3 efficiency observation indexs

6 cardinal symptom of table improves situation

In terms of each cardinal symptom improvement, granule group of the present invention is better than control group.

7 effect of table compares

Before and after 8 two groups of test-meals of table fasting blood-glucoses compare (mmol/L,)

* P < 0.05 is compareed between 0.01 group of < of own control * * P

After one month, test-meal group fasting blood-glucose declines 0.92mmol/L, and control group fasting blood-glucose declines 0.07mmol/L, Two groups relatively have notable difference.

Before and after 9 two groups of test-meals of table 2 hours blood glucose of postprandial blood sugar compare (mmol/L,)

* P < 0.05 is compareed between 0.01 group of < of own control * * P

After one month, the postprandial 2 hours blood glucose of test-meal group declines 1.77mmol/L, own control significant difference, control group meal Blood glucose decline in 2 hours is unobvious afterwards, and two groups relatively have notable difference.

The variation of glucose in urine urine ketone bodies is compared before and after 10 test-meal of table(integrated value)

Blood Lipid compares before and after 11 test-meal of table

Case depigmentation rate: test-meal group and control group selected case are respectively 50, wherein have 2 at the end of test-meal group test-meal Tested material is not taken by regulation, 5 are not checked in the stipulated time；Control group has 4 not check in the stipulated time, and 3 midways are moved back Out.Test-meal group and control group respectively have 7 to meet subject's discharge standard, and case depigmentation rate is 14.00%.

It can be seen that prevention and treatment diabetes and complication composition of the invention as health food one from above-mentioned experiment Fasting blood-glucose declines 0.921.11mmol/L after a month, declines percentage 10.24%；Postprandial blood sugar decline 1.77 ± 1.55mmol/L, decline percentage are 13.16%.Wherein effective 32, total effective rate 64.00%；Control group blood glucose declines not Obviously, wherein effective 5, total effective rate 10.00%, two groups relatively have significant difference, and the present invention prevents and treats diabetic composition There is good function of blood sugar reduction.

The present invention, which prevents and treats diabetes and complication composition, has improvement to the examination trencherman mostly cardinal symptoms such as food, more drinks, out of strength Effect, after the test-meal present composition, hemoglobin, Lactoferrin, albumin, total serum protein, albumin, glutamic-pyruvic transaminase, Glutamic-oxalacetic transaminease, inosine, urea, routine urinalysis (except glucose in urine), just the indices such as conventional are substantially in normal range (NR), cholesterol, Triglycerides, high-density lipoprotein cholesterol variation are unobvious, illustrate the present composition to examination trencherman's health without bad It influences.

(2) animal experiment is reported

Experimental animal: The Fourth Military Medical University animal testing center provides cleaning grade Kunming mouse (24~28g).Cleaning Grade animal house raising, 25 DEG C of feeding environment temperature, humidity 60%RH.

Key instrument and reagent

Reagent: alloxan is provided by Sigma Co., USA.

Instrument: Luo Kangquan blood glucose meter (TM) is provided by Roche Shanghai Co., Ltd.

Dosage grouping and given the test agent give the time

Present composition human body recommended intake is 18g/60KgBW/ days i.e. 0.3g/KgBW/ days, is extrapolated small Mouse daily intake are as follows: low dose group 3g/KgBW/ days；Middle dose group 6g/KgBW/ days；High dose group 12g/KgBW/ Day；It is respectively equivalent to 10,20,30 times of daily intake.Given the test agent is configured to 15%, 30% and 60% with pure water Solution, reference substance gives isometric distilled water, and daily stomach-filling is primary, and stomach-filling amount is calculated by 0.2ml/10g weight, continuous 30 It.Animal ad lib, drinking-water.

Test method

(1) to the influence of normal mouse blood glucose

Select 26 ± 2g Healthy female mouse, according to 4 hours blood glucose levels of fasting be randomly divided into a Normal group and One normal high dose group, every group of 11 mouse.Normal group gives distilled water stomach-filling, and high dose group gives of the present invention group Object high dose stomach-filling concentration is closed, stomach-filling amount and stomach-filling time are the same.

(2) to the influence of hyperglycemia model mouse fasting blood-glucose

The foundation of hyperglycemia model mouse: after above-mentioned Kunming mouse fasting 24 hours, with the alloxan newly configured By 150mg/KgBW/d, after 7 days fasting 4 hours, tail vein blood, measure blood glucose value with blood glucose meter, select blood glucose value The mouse of 10mmol/L~25mmol/L is hyperglycemia model success animal.Divide at random according to blood glucose value a model control group and Three dosage groups give distilled water and present composition stomach-filling liquid respectively, and stomach-filling amount and stomach-filling time are the same.It is examined after 30 days Fasting blood sugar after surveying fasting 4 hours, and be compared.

(3) carbohydrate tolerance test

After groups of animals gives tested material 30 days, fasting 4 hours, each dosage group mouse gave the tested of former dosage respectively Object, control group give isometric distilled water stomach-filling.Every group of animal in stomach-filling after twenty minutes, give 20% medical starch it is molten Liquid stomach-filling, stomach-filling amount are 10.2ml/10gBW, measure 0h, 1h, 2h blood glucose value, compare each group experimental animal and give medical shallow lake The variation of each time point Area under the curve of blood glucose after powder.

Statistical method: one-way analysis of variance, the fasting blood glucose level of more each dosage group mouse and carbohydrate tolerance test with Difference between high sugar control.

Interpretation of result:

(1) to the influence of mouse weight

Influence of the table 12 to mouse weight

Influence of the table 13 to diabetic mice weight

(2) to the influence of mouse fasting blood-glucose

Influence of the table 14 to normal mouse fasting blood-glucose

Influence of the table 15 to diabetic mice fasting blood-glucose

* the P < 0.05 compared with model group response；* P < 0.01 compared with model group response.

(3) to the influence of diabetic mice sugar tolerance

Influence of the table 16 to diabetic mice sugar tolerance

* indicate there be significant difference (p < 0.05) compared with high sugared model control group

Using the present composition submitted sample of 3g/KgBW, 6g/kgBW, 12g/kgBW dosage, four are given Hyperglycemia model mouse continuous gavage 30 days of oxygen pyrimidine induction.

As the result is shown: can be substantially reduced diabetic mice after the basic, normal, high three dosage groups treatment of particle of the present invention Fasting blood sugar；High dose group can be substantially reduced compared with high sugared model control group give medical starch after 0,1,2 hour blood glucose Area under the curve, carbohydrate tolerance test result are positive.It can determine that, the present composition has the function of to be substantially reduced blood glucose.

Test example three

To the observation of curative effect of diabetic retinopathy

The patient that 60 meet diabetic retinopathy is randomly divided into two groups, treatment group 30, control group 30. Control group is treated using simple western medicine, controls blood glucose and diet, and treatment group adds on the basis of Western medicine controls blood glucose and diet The tablet of the embodiment of the present invention two, as a result in treatment group 30, effective 15, effective 12, invalid 3, total effective rate is 90.0%.Effective 4 in control group 30, effective 8, invalid 18, total effective rate 40.0%, two groups of curative effects relatively have Significant difference (P < 0.05).

Test example four

To the observation of curative effect of diabetic nephropathy

80 patients are randomly divided into treatment group and control group.Two groups are given identical Diabetes Foundation treatment, treatment group Using the tea beverage joint enalapril treatment of the embodiment of the present invention four, control group is applied alone enalapril to treat, and the course for the treatment of is 2 The two groups of pretherapy and post-treatment symptoms of observation in a month, sign, blood glucose, blood pressure, UAER and for 24 hours quantity of proteinuria situations such as.As a result: treatment The pretherapy and post-treatment symptom of group and somatic feature score compare, and difference has significant (P < 0.05)；Treatment group treatment after UAER and Quantity of proteinuria has decline for 24 hours, and before and after treatment relatively, difference has significant (P < 0.05).Treatment group in UAER and Control group is superior in terms of the improvement of quantity of proteinuria for 24 hours.Total effective rate treatment group is 82.50%, and control group is 37.50%, two groups of curative effects compare, and difference has significant (P < 0.05).Show that product of the present invention has diabetic nephropathy There is higher adjuvant treatment effect.

Test example five

To the observation of curative effect of diabete peripheral herve pathology

60 diabetics have different degrees of nerve conduction velocity to slow down through electromyography, and exclude other originals The peripheral neuropathy because caused by.Clinical manifestation: except there is different degrees of more drinks, diuresis eat more, thin, the diabetes such as out of strength Main symptom outside, have different degrees of symmetry limb end numbness, the sense of ant row, pain, daytime light night weight, limb end is symmetrical Property in various degree " gloves ", " ankle socks " sample sensory disturbance, tendon reflex can be normal, can also weaken or disappear.It keeps on a diet, blood glucose Antidiabetic drug can be given by declining undesirable person, while take sample made of the embodiment of the present invention five.

Criterion of therapeutical effect: effective: pain all disappears, and nerve conduction velocity improves 5m/s；

Effective: pain is substantially reduced, and nerve conduction velocity improves 5m/s；

Invalid: pain is unchanged, and nerve conduction velocity is without improvement.

Treatment results: effective 18, effective 36, invalid 6, total effective rate 90.0%.

Claims (10)

1. the composition of a kind of prevention and treatment diabetes and complication, which is characterized in that including 3~30 parts of corn stigma, American Ginseng 2~6 Part, 3~30 parts of Radix Astragali, 2~15 parts of radix rehmanniae recen, 3~15 parts of pueraria lobata, 3~30 parts of Radix Codonopsis, 2~10 parts of mulberry leaf, 1~10 part of radix bupleuri, 0.00002~0.0002 part of trivalent chromium, 1~3 part of water-soluble dietary fiber, 1~15 part of insoluble diedairy fiber, edible insects 2~9 parts of component of 1~20 part of component, 2~6 parts of nourishing kidney yin component, 1~5 part of dredging vascellum component and hemostasis.

2. the composition of prevention and treatment diabetes according to claim 1 and complication, which is characterized in that the composition also wraps Containing 1~3 part of blood vessel elasticity component of increase.

3. the composition of prevention and treatment diabetes according to claim 2 and complication, which is characterized in that the increase blood vessel bullet Property group is divided into lecithin, deep sea fish oil, black fungus, garlic, onion, tomato, apple, nut, hawthorn, green tea, Semen sesami nigrum, sea Band, eggplant, corn, jujube, carrot, grape wine, any one or any combination in vinegar.

4. the composition of described in any item prevention and treatment diabetes and complication according to claim 1~3, which is characterized in that also wrap Include neurotrophy component: 0.1~0.5 part；The neurotrophy component includes phosphatidylserine, arachidonic acid oil, fish Oil and extract, γ-aminobutyric acid (GABA), any one or any combination in phosphatide.

5. the composition of prevention and treatment diabetes according to claim 4 and complication, which is characterized in that the trivalent chromium includes Any one in Organic Chromium and inorganic chromium or any combination, the Organic Chromium include animal's liver, Cr-enriched yeast, nicotinate chromium, institute Stating inorganic chromium includes chromium sulfate and/or chromium trichloride.

6. the composition of prevention and treatment diabetes according to claim 5 and complication, which is characterized in that the aqueous soluble dietary Fiber include resistant dextrin, konjaku flour, xylo-oligosaccharide, oligofructose, inulin, polydextrose, stachyose, oligoisomaltose, Any one in isomaltoketose, chitosan or any combination；The insoluble diedairy fiber includes Cillium, oat meals Eat fiber, quinoa dietary fiber, wheat bran dietary fiber, buckwheat dietary fibers, barley seedling powder, mushroom powder, celery powder, spinach Powder, broccoli powder, hedgehog hydnum mushroom powder, any one in apple powder or any combination.

7. the composition of prevention and treatment diabetes according to claim 5 and complication, which is characterized in that edible insects component Selected from bamboo worm, sandworm, ant egg, locust, bavin worm, willow worm, chrysalis, chrysalis, bee pupa, ant, honeybee, greenish brown hawk moth, yellow meal worm, Any one in Asiatic migrotory locust adult or any combination.

8. the composition of prevention and treatment diabetes according to claim 5 and complication, which is characterized in that the nourishing kidney yin group Be selected from tortoise meat, pigeon meat, perch, dog meats, dried scallop, cicada, animal kidney, Rehmannia glutinosa, mulberries, tortoiseshell, fructus lycii, Schisandra chinensis, Chinese yam, Semen Cuscutae, oyster, Gorgon fruit, any one in the fleece-flower root or any combination；

The dredging vascellum component includes Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Gastrodiae, Radix Notoginseng, hawthorn, peach kernel, safflower, Radix Angelicae Sinensis, radix paeoniae rubra, cattail pollen, cream Perfume, myrrh, rhizoma corydalis, curcuma zedoary, any one or any combination in Herba Lycopi；

The hemostasis component includes crinis trachycarpi, charred NODUS NELUMBINIS RHIZOMATIS, charred RADIX ANGELICAE SINENSIS, charred RADIX RUBIAE, charred HERBA CIRSII JAPONICI, charred RHIZOMA OSMUNDAE SEU DRYOPTERIS CRASSIRHICOMAE, rhizoma imperatae charcoal, hairyvein agrimony Charcoal, bletilla, carbonized hair, folium callicarpae pedunculatae, Loropetalum wood, clinopodium polycephalum, any one in cockscomb or any combination.

9. the drug of diabetes, health care are being treated and alleviated to the composition of prevention and treatment diabetes described in claim 1 and complication Application in terms of food or functional food.

10. the composition of prevention and treatment diabetes described in claim 1 and complication is alleviating diabetes complicated disease drug, health care food Application in terms of product or functional food.