CN103736071B - A kind of composition with auxiliary hyperglycemic effect and application thereof, preparation method - Google Patents
A kind of composition with auxiliary hyperglycemic effect and application thereof, preparation method Download PDFInfo
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Abstract
The present invention uses for reference the Qinghai-xizang Plateau Region common people and tackles the experience in unique dietary that unfavorable geographic climate forms, and discloses a kind of composition with auxiliary hyperglycemic effect. Present composition raw material consists of 100 parts～300 parts, highland barley, 100 parts～300 parts of emblics, 100 parts～300 parts, turmeric, 50 parts～150 parts of rhizoma zingiberis, 50 parts～150 parts of sea-buckthorn parts, 50 parts～150 parts, bent letter. The present invention also provides composition in the application of preparing in health food and/or functional food and/or medicine, specifically for health food and/or functional food and/or the medicine of diabetes-alleviating hyperglycaemia symptom. The present invention also provides the health food and/or functional food and/or the medicine that contain the present composition, and the preparation method of product.
Description
Technical field
The present invention relates to a kind of composition, particularly relate to a kind of group with auxiliary hyperglycemic effectCompound and preparation method thereof.
Background technology
Blood sugar refers to the glucose being present in blood, mainly from food. Blood sugar will pass through pancreas islet BThe insulin action of the secretion of cell, just can enter and in cell, carry out metabolism, produce power. Work as pancreasGland deterioration, hypoinsulinism, there will be high-level blood sugar in blood to inhale in timeReceive, on an empty stomach or still high after having a meal two hours, form hyperglycemia state, blood because ofAnd become sticky, and be easy to solidify, cause life danger. Modern medicine study confirms, causes bodyThe many factors that blood sugar raises, for example emotional factors imbalance stimulates adrenaline secretion increase, dietUncomfortable, various physical stresses, some drugs factor, concurrent various infection, body produce insulinThe factors such as opposing all can cause blood sugar to raise. Although hyperglycaemia symptom is not inevitable relevant with diabetes,But most hyperglycemias are relevant with diabetes, and because diabetes are as a kind of endocrine generationThanking to disease, is because insulin in body is absolute or relative deficiency causes taking carbohydrate metabolism disturbance as main eggA kind of syndrome of white matter, fat, dielectric, acid-base balance metabolic disorder, thereby diabetes areCardinal symptom is hyperglycemia. Because diabetes cannot be cured, therefore diabetes patient needs longPhase is adhered to specification treatment, as medicine treatment, dietary therapy and the physical training of specification. Also can simultaneouslyWith the more matched food with auxiliary hyperglycemic effect, in order to control glucostasis, prevention alsoSend out the generation of disease, improve quality of life.
The bad climate environment such as height above sea level, the air of China Qinghai-xizang Plateau Region is dried, oxygen is thinCondition, dietary structure is simple, and taking beef and mutton as main. Qinghai-Tibet Platean resident is reply altitude environmentUnfavorable conditions, in daily life diet, accumulated a large amount of with regulate personal functional activity, maintainThe experience that health physiological health state is relevant.
Summary of the invention
Object of the present invention utilizes traditional Qinghai-Tibet diet experience to provide one to have auxiliary falling exactlyThe composition of blood sugar effect and application thereof, preparation method.
For achieving the above object, technical scheme of the present invention is as follows:
A composition with auxiliary hyperglycemic effect, is characterized in that: raw material components is highland barley100 parts～300 parts, 100 parts～300 parts of emblics, 100 parts～300 parts, turmeric, rhizoma zingiberis 50Part～150 parts, 50 parts～150 parts of sea-buckthorn parts, 50 parts～150 parts, bent letter.
In above-mentioned composition, each component is:
Highland barley, (HordeumvulgareL.var.nudumhook.f.) is China Qinghai-xizang Plateau RegionTo the general designation of the naked grain of many ribs barley, also cry highland barley, Huaihe River wheat, meter great Mai or hull-less barley in other producing regions,Be a kind of specific type of barley, in Plant Taxonomy, belong to the mutation of grass family Hordeum barleyOne of. Modern food analysis and research confirm, highland barley have high protein, high fiber, homovitamin,Low sugar and low-fat feature. Be rich in several amino acids, dietary fiber, vitamin, mineral matter andBeta glucan, is reducing blood fat, is reducing blood sugar, is increasing stomach power, is preventing altitude sickness and diabetesEtc. aspect there is good efficacy, be a kind of healthy food and health care with wide application and development prospectFood. Wherein, beta glucan is a kind of SNSP of cereal endosperm and gluten cell wall,Be a kind of compound glucose polymerisation sugar, its molecular weight is less than cellulose. The sixties in 20th century,Research finds that beta glucan has the effect of reducing blood lipid, norcholesterol and angiocardiopathy preventing gradually,The adjusting blood sugar of beta glucan, raising immunity, antineoplastic action are also found successively subsequently.More and more many medical research have confirmed that beta glucan to difficult disease such as tumour, hepatitis, diabetes allThere is good result for the treatment of. At present, biomedical boundary generally believes that beta glucan has gut purge, tuneThe four large physiological actions such as joint blood sugar, reduction cholesterol, raising immunity. As beta glucan contentThe highest wheat class plant, the value of highland barley food exploitation is high.
Emblic, is Euphorbiaceae phyllanthus emblica platymiscium emblic (PhyllanthusemblicaL.),A lot of places, south are the common common wild fruits often eaten of people, can eat raw, after can processing againMake the pickles of going with rice or bread, also can be processed into senior preserved fruit, or be processed into multiple special local food.Traditional medicine viewpoint thinks that the dry mature fruit nature and flavor of emblic are sweet, sour, puckery, cool; Return lung,Stomach warp, main effect is clearing heat and cooling blood, food digesting stomach fortifying, the cough-relieving of promoting the production of body fluid, for blood-head blood stasis,Liver and bladder disease, indigestion, stomachache, cough, laryngalgia, dry. Modern chemistry composition Study showsEmblic nutritive value is abundant, containing 12 kinds of vitamins, 18 seed amino acids, 16 kinds of magnanimities and traceElement, is rich in tannin, organic acid, phenols etc., also contains unrighted acid in kernel. EspeciallyVitamin C content extra-high-speed, fresh fruit can reach 400-500mg/100g, and contained vitamin in fruitC is very stable under the high heat of high temperature.
Turmeric is the dry rhizome of zingiberaceous plant turmeric (CurcumalongaL.). Its rhizome instituteThe buff powder of wearing into is one of main spices in cooking. Traditional medicine think turmeric nature and flavor pungent,Bitter, warm; Return spleen, Liver Channel. Broken blood gas, inducing meastruation to relieve menalgia. Twinge amenorrhoea ， wei for the chest side of bodyLump in the abdomen, rheumatism shoulder arm pain, tumbling and swelling. Modern chemistry composition Study shows that turmeric is to hepatitis viruseThere is inhibitory action, be improved the effect of liver essence disease damage, its main component curcumin (curcumin)There is the effect of health care.
Rhizoma zingiberis, is the dry rhizome of zingiber (ZingiberofficinaleRosc.), isConventional medicine-food two-purpose food materials have very important effect in diet, health care. TraditionMedical science thinks that dry nature and flavor are pungent, hot; Return spleen, stomach, kidney, cardiopulmonary warp. Modern chemistry composition StudyShow that rhizoma zingiberis is mainly containing Rhizoma Zingiberis oil volatile ingredient, also containing the peppery sulfonic acid of 6-ginger(6-gingesulfonicacid), 5-outer-hydroxyl borneol-2-O-β-D-glucopyanoside(angelicoidenol-2-O-β-D-glucopyranoside) and ginger glycolipid (gingerglycolipid) A, B,C. Confirm through pharmacology test, this product has protection gastric mucosal cell, suppresses gastric acidity and secretion,Reduce blood pressure, stimulate circulation, suppress the effects such as central nervous system.
Sea-buckthorn is the mellow fruit of Elaeangnaceae hippophae plant sea-buckthorn (Hippophaethibetana)Real. Sea buckthorn fruit contains abundant nutriment and bioactivator is China's plateau food developmentIn conventional raw material. Traditional view is thought sea-buckthorn nature and flavor acid, puckery, warm. Cough-relieving apophlegmatic, digestion-promotingStagnant, promoting blood circulation to remove blood stasis. For coughing with a lot of sputum, indigestion, dyspeptic abdominalgia, hemostasis, through closing, falls and fluttersThe stasis of blood is swollen. Modern chemistry composition Study shows that sea-buckthorn is containing Isorhamnetin, Isorhamnetin-3-B-D-glucoseThe low glucoside of glucoside, Isorhamnetin-3-B-rutinoside, Mongolian oak chitin and Kaempferol. Through pharmacology testConfirm, this product has can reduce cholesterol, cures the effects such as angina pectoris, prevents and treats in addition coronary arteryThe effect of atherosclerotic heart disease; Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the work of chronic bronchitisWith; Can treat gastric duodenal ulcer and indigestion etc., to chronic superficial gastritis, witherThe illnesss such as contracting gastritis, colitis are evident in efficacy; Have fine to burn, scald, cutter burning, frostbiteTherapeutic action; Cervical erosion is had to good result for the treatment of.
Bent letter, another name Indian rhubarb, franzenbach rhubarb root and rhizome, oxtail seven, large rock seven, be that polygonaceae plant is hidden limitThe dry root and rhizome of rheum officinale (RheumemodiWall.). Bent letter nature and flavor hardship, cold; Return spleen,Stomach, large intestine, liver the heart channel of Hang-Shaoyin. The logical intestines that purge heat, removing pattogenic heat from the blood and toxic material from the body, stimulates the menstrual flow by the stasis of blood. Modern chemistry composition grindsStudy carefully demonstration, rheum officinale mainly contains anthraquinone glycoside and dianthracene ketone glucoside. Confirm through pharmacology test, this product hasHemostasis, reducing blood lipid, anti-infective, under rushing down, sharp liver, protects the effects such as courage.
In the present composition, hypoglycemic, adjusting that highland barley, emblic, turmeric Main Function areBlood fat is to play the component of main effect, sea-buckthorn, rhizoma zingiberis, bent letter for cardinal symptom in componentPlay auxiliary antilipemic, hypoglycemic activity, and balanced action.
Under optimum condition, combinations thereof raw material consist of 200 parts, highland barley, 200 parts of emblics,200 parts, turmeric, rhizoma zingiberis 100, sea-buckthorn 100, bent letter 100.
The present invention also provides the purposes of above-mentioned composition: the present invention has the group of auxiliary hyperglycemic effectCompound is in the application of preparing in health food and/or functional food and/or medicine. Specifically for alleviatingThe health food of diabetic hyperglycemia shape and/or functional food and/or medicine.
The present invention also provides the health food and/or functional food and/or the medicine that contain above-mentioned composition.These health foods and/or functional food and/or medicine are taking oral type as main.
The present invention also provides the method for the above-mentioned health food of preparation and/or functional food and/or medicine, itsTechnical scheme is: each raw material components is configured in proportion, according to traditional patent medicine processing method, necessityTime add acceptable auxiliary material in pharmacy to be prepared into different dosage form. Oral type can comprise solutionAgent, tablet, capsule, granule, powder etc.
Compared with prior art, the invention has the beneficial effects as follows: the present composition is tested animal and facedBed medication evidence can be assisted and be reduced animal blood glucose level, is that one has auxiliary hyperglycemic meritThe new compositions of effect; (2) present composition can be applied to health food and/or functional food and/ or medicine; (3) present composition is for the preparation of health food and/or functional food and/or medicine,Preparation method is simple and easy to control; (4) present composition raw material is common in Tibet region, conventional, peaceComplete reliable.
Detailed description of the invention
Below in conjunction with embodiment, technical scheme of the present invention is further described.
Embodiment mono-
The present invention has the method for preparing tablet thereof of the composition of auxiliary hyperglycemic effect.
1, raw material preparation
Present composition raw material is the material of integration of drinking and medicinal herbs, preparing in embodiment for avoidingRaw material is subject to seasonal restriction, thereby each raw material all gets the medicinal material after clean system, and consumption is as shown in table 1 below:
Table 1 has the composition raw materials of effect of weight reducing
2, processing method
Highland barley, frying, pulverized 100 mesh sieves, made highland barley flour stand-by.
Except highland barley, all the other raw materials add 10 times of water gagings of weight, soak 1h, 98 DEG C～100 DEG C decoctions2h, filters, and collects the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C～100 DEG C decoct 1h,Filter, merge twice filtrate, spraying is dry; Add highland barley flour, mix, obtain composition powder.
Resulting composition powder, wet granulation, dry, whole grain, compressing tablet, dressing, every heavy 0.6～1.0g,Obtain.
Embodiment bis-
The present invention has the capsule preparation method thereof of the composition of auxiliary hyperglycemic effect.
Embodiment mono-resulting composition powder, dry, pulverizing, sieves, filled capsules, every dress0.4～0.6g, to obtain final product.
Embodiment tri-
The present invention has the oral liquor of the composition of effect of weight reducing.
Raw material adds 10 times of water gagings of weight, soaks 1h, and 98 DEG C～100 DEG C decoct 2h, filter, and collectThe another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C～100 DEG C decoct 1h, filter, and merge twiceFiltrate, filtrate is concentrated into 1:10(and medicinal material ratio), concentrate add honey, white granulated sugar, citric acid,Potassium sorbate, purified water, filter, filling, hot pressing steam sterilizing, packaging, to obtain final product.
Test example one
Safe toxicology test.
Test specimen: embodiment mono-resulting composition tablet grinding flour.
Adopt present composition test specimen to carry out respectively acute oral toxicity test, genetoxicTest and rat 30d feeding trial.
1, acute oral toxicity test
Get 80 of ICR mouse, be divided at random 4 groups by body weight, be divided into test group and (be divided into example oneThe 1st group, the 2nd group, the 3rd group) and control group each, 20 every group, male and female half and half. Before testICR mouse fasting 12h experimental group gavage gives the test sample solution of Cmax 16.7%, everyInferior 0.30ml/10g, interval 4h is administered once, and every day, 3 control group gavages gave equal-volume physiologySalt solution. After administration, normal granules material is raised, freely drink water, and natural lighting 12h/12h, room temperature20～24 DEG C, humidity 60%. Reaction of animals in Continuous Observation one week, puts to death mouse and carries out after 1 weekAutopsy examination.
After administration, there is diarrhoea in experimental mice, and 15 animals occur yellow just rare. Different without cryOften, tremble, convulsions, ataxia, salivate, shed tears, have a running nose, shed tears, have difficulty in breathing,The phenomenon such as constipation, intestinal tympanites occurs. Animal skin is compared with gloss, none death of mouse in administration one week,Administration the 3rd, 8d weigh respectively, and changes of weight obviously alleviates compared with control group, after 8d weighs by onlyPut to death and dissect, visually observe the heart, liver, spleen, lung, kidney, adrenal gland, thymus gland, ovary, uterus,Seminal vesicle, prostate, testis, stomach, intestines and thoracic cavity, abdominal cavity, each organ is all without abnormal.
2, genetic toxicity test
2.1Ames test
Adopt through identifying satisfactory TA97, TA98, TA100 and TA102 bacterial strain, carry outAdd with the dressing plate that does not add rats'liver S9 and mix method test (S9mix consumption is 0.5ml/ plate).If five dosage of present composition test specimen: 8 μ g/ plates, 40 μ g/ plates, 200 μ g/ plates, 1000 μ g/Plate, 5000 μ g/ plates (accurately take present composition test specimen 1.0g in vial, add steamingHeat up in a steamer water 20ml, after fully mixing, be high workload concentration 50mg/ml, all the other concentration distilled water5 times down dilution obtain, the high workload concentration 100 μ l of configuration add flat board to be the highest final concentration5000 μ g/ plates, all the other concentration application of sample amounts are 100 μ l. Solution after all preparations adopts 8 pounds15min high pressure mode is carried out sterilizing), establish spontaneous contrast, solvent control (sterile purified water simultaneously100 μ l/ plates) and positive control. The positive control that does not add S9 test is 2,4 of 0.2 μ g/ plate, 7-tri-nitreBase-9-Fluorenone (TA97, TA98), the sodium azide (TA100) of 1.5 μ g/ plates, the silk of 0.5 μ g/ plateRimocidin C(TA102); The positive control that adds S9 test be the 2-aminofluorene of 10 μ g/ plates (TA97,TA98, TA100) and 50 μ g/ plates 1,8-dihydroxy anthraquinone (TA102). Each test dose is doneThree parallel-plates, repeat test once.
Result: no matter add and the test that does not add S9, every plate of spontaneous control group on average returns change clump countAll in range of normal value, and every plate that positive controls is brought out on average returns and becomes clump count and be spontaneousControl group more than two times, is obvious positive reaction. The each dosage group of present composition test specimenAverage returning becomes clump count and all do not exceed a times of spontaneous control group, the reaction that is negative, of the present invention groupCompound test specimen is without the effect of induction experiment bacterial strain back mutation.
2.2 PCEMNR micronucleus tests
Kunming mouse (body weight 25g～30g) is divided into 5 groups at random, and 10 every group, male and female are eachHalf, establish 2.5g/kg.bw, 5.0g/kg.bw and 10.0g/kg.bw present composition test group, anotherIf negative control group (distilled water), positive control (endoxan 40mg/kg.bw) group. AnimalPress 0.2ml/10gbw per os gavage respectively at 0h and 24h, after last contamination, 6h puts to deathAnimal, follow procedure film-making. Every animal 1000 polychromatic erythrocytes of counting (PCE), observeThe polychromatic erythrocyte number that contains micronucleus, calculates micronuclear rates (‰), observes 200 red blood cells simultaneouslyMiddle PCE and just incarnadining the shared number of cell (NCE), and calculate PCE/NCE ratio.
Result: positive controls is female, the micronuclear rates of tom is all significantly higher than control group (P < 0.05),The micronuclear rates of the each group of the extract of the present composition and negative control group comparison there are no significant difference(P > 0.05). Prompting, present composition test specimen is in mouse marrow cell micro nuclear testNegative findings.
2.3 mouse sperm deformity tests
Male Kunming strain mice (body weight 25g～35g) is divided into 5 groups at random, 5 every group. TestPacket design is with 2.2, every day per os gastric infusion once, 5d continuously. With 35d after gavage firstPut to death animal, get bilateral epididymis, film-making in accordance with regulations, every animal is observed 1000 complete sperms,Record all kinds of defective sperm numbers.
Result: positive controls rate of teratosperm is all significantly higher than control group (P < 0.05), the present inventionThe rate of teratosperm of the each group of the extract of composition and negative control group comparison there are no significant difference(P > 0.05), prompting, present composition test specimen is negative in mouse sperm deformity testResult.
Salmonella reversion test, PCEMNR micronucleus test and mouse sperm deformity test etc.Three genetic toxicity test results are all negative, show that the extract of the present composition is without mutagenesisEffect.
3, rat 30d feeding trial
Get 200 of the Wistar rats of firm weaning weight 60g～90g, after laboratory observation 3d,Be divided at random 10 groups by body weight, be respectively Normal group, present composition test specimen (pointFor the 1st group of example 1, the 2nd group, the 3rd group) basic, normal, high dosage group, 20 every group,Male and female half and half. Normal group per os gavage gives distilled water, basic, normal, high dosage group warp respectivelyMouth gavage gives extract 1.5g/kg.bw, 3.0g/kg.bw and 6.0g/kg.bw(is equivalent to respectively people25,50 and 100 times of body recommended intake), administration volume is 10ml/kg.bw, gives continuouslyMedicine 30d, result shows that body weight, the food (feed) of the present composition to animal used as test utilizesRate, hematological examination (red blood cell count(RBC), hemoglobin, white blood cell count(WBC) and classification), blood lifeThe inspection of chemistry indices (AST, ALT, Glu, BUN, TP, Alb, TC, TG,CRE) result all with negative control group (intact animal) without significant difference. The present composition pairThe liver,spleen,kidney of animal used as test, testis, stomach and intestine, ovary all do not detect from macroscopical anatomyWith the notable difference of negative control group, also do not find that the Histopathology relevant with empirical factor changes.30d feeding trial has no it has overt toxicity detrimental effect to animal subject.
Test example two
Function assessment test: hypoglycemic activity and mechanism test thereof
Animal used as test: 50 of kunming mices, male, body weight 20 ± 2g(is purchased from Chinese medicine sectionInstitute's animal center).
Test specimen is with test example one.
Test method: be divided at random 5 groups. L group is Normal group, administration group fasting 12hAfter, the modeling of lumbar injection 200mg/kg alloxan. After 24h, start administration. The 2nd group gavagesDrinking water 0.3ml/10g, the 3rd group gavages the 1st group of present composition 0.3ml/10g of example 1,The 4th group gavages the 2nd group of present composition 0.3ml/10g of example 1, and the 5th group gavages exampleOne the 3rd group of present composition 0.3ml/10g. Successive administration l0d, gets blood in 11d, surveys bloodSugar concentration.
Result of the test
Blood sugar determination GOD-PAP method (being provided by kit)
The comparison of the each group of table 2 mouse blood sugar concentration
Note: the 2nd group and the 1st group is compared P < 0.01, the 3rd group is compared P < 0.01 with the 2nd group, and the 4th group is compared P < 0.01 with the 2nd group,The 5th group is compared P < 0.01 with the 2nd group.
Conclusion: result statistics from showing, modeling group and the contrast of normal group blood sugar concentration, tool is remarkableProperty difference (P < 0.01), illustrate with alloxan modeling success. After modeling, give the present composition,Blood sugar concentration is all starkly lower than modeling group (P < 0.01), illustrates that the present composition has the definite blood that fallsSugar effect. Body is taken in after the present composition can pass through anticoagulation, preventing thrombosis form to block because ofFibrinolytic is resisted after reducing the insulin receptor causing, and blocks acceptor by correcting metabolic disorderWith insulin resistance after acceptor. Can be by suppressing short coagulating and the promoting blood thickness series factor in liver cellRelease block and control insulin resistance after acceptor.
Test example three
To diabetic's clinical observation on the therapeutic effect.
1, clinical data
All cases is all from the attached Yinchuan of traditional chinese medical science clinic of Ningxia Medical University and Ningxia Medical UniversityThe diabetes section outpatient service of the hospital of traditional Chinese hospital of city and inpatient department, totally 50 examples, all meet WHO diabetologistThe committee propose diagnostic criteria (1999): diabetic symptom add random time plasma glucose >=11.1mmol/L(200mg/dl), or FPG >=7.0mmol/L(126mg/dl), or OGTT2hPG >=11.1mmol/L(200mg/dl). Need repeat once to confirm, diagnosis could be set up. All troublePerson's serum triglyceride (TG) > l.70mmol/L(normal value be 0.57～l.70mmol/L) or bloodClearing gallbladder sterol (TC) > 5.69mmol/L(normal value is 2.33～5.69mmol/L).
Be divided at random two groups. wherein treatment group 30 examples, male 16 examples, female's 14 examples: 40 years old age～70 years old, average 60.56 years old; The course of disease 3 years～20 years, average 8.5 years; Complicated hypertension disease 12Example, merges cerebrovascular disease 3 examples, merges eyeground pathological changes 5 examples, merges ephrosis 7 examples, merges tipDPN 8 examples, merge lower limb gangrene 1 example. Control group 20 examples, male 11 examples, female's 9 examples:42 years old～70 years old age, average 58.65 years old; The course of disease 3 years～25 years, average 7.9 years; MergeHigh blood pressure 7 examples, merge cerebrovascular disease 2 examples, merge eyeground pathological changes 4 examples, merge ephrosis 5 examples,Merge Peripheral neuropathy 6 examples. Two groups of patients' sex, age, the course of disease, complication etc. are through systemMeter processing (P > 0.05), no significant difference, illustrates that two groups of patients have comparativity.
2, methods for the treatment of
All cases is all taked to keep on a diet, appropriate exercise, conventional oral sulfonylureas add biguanide drugThing.
Treatment group gives the embodiment of the present invention one composition of medicine: oral, 2 times on the one, one time 3.
The oral blood fat recovery capsule of control group, once two, every day 2 times. The accurate word Z10950029 of traditional Chinese medicines,0.3g*12 grain, reform bio tech ltd of Beijing Beijing University produces.
The course for the treatment of: 1 month be the l course for the treatment of, observe altogether 2 courses for the treatment of.
3, observation index
Fasting blood-glucose (FPG), 2h-plasma glucose (PBG) and the blood red egg of saccharification (HbAlc).Two groups are all detected FPG, PBG, HbAlc before and after treatment.
Blood fat indices: comprise T-CHOL (TC), triglycerides (TG), high density lipoprotein level(HDL-C), low-density lipoprotein (LDL-C) in vain. Two groups all in treatment before and after detect TC, TG,HDL-C、LDL-C。
Observation of curative effect: with reference to " the new Chinese medicine guideline of clinical investigations " of Ministry of Public Health's formulation in 2000The criterion of therapeutical effect of middle hyperlipemia: clinic control: the every inspection in laboratory recovers normal. Effective:Lipids detection reaches following any one person: TC decline >=20%, TG decline >=40%, HDL-CRising >=0.26mmol/L(10mg/dl). Effective: lipids detection reaches following any one person: TCDecline >=10% but < 20%, TG declines >=20% but < 40%, and HDL-C rises >=0.104Mmol/L(4mg/dl) but < 0.26mmol/L(10mg/dl). Invalid: lipids detection fails to reachTo above standard person.
4, statistical procedures
Every detection data represent with mean ± standard deviation, t inspection and single factor side for measurement dataDifference analysis, enumeration data χ2Inspection.
5, treatment results
Two groups of Clinical efficacy comparison treatment group 30 examples, clinic control 2 examples, effective 14 examples, effectively10 examples, invalid 4 examples, total effective rate 86.67%; Control group 20 examples, clinic control 1 example, aobviousImitate 4 examples, effective 8 examples, invalid 7 examples, total effective rate 65%. Two groups of Different therapeutical effects have conspicuousness（P<0.05）。
After two groups of treatments, lipids indexes is all improved, but treatment group improvement degree is better than control group(P < 0.01), in table 3.
Blood fat indices comparison before and after table 3 liang group treatment
Note: with relatively P < 0.01 for the treatment of group,★P < 0.05, relatively front with treatment▲▲P<0.01，▲P<0.05
Two groups of FPG, PBG and HbAlc all have decline, but improve more obvious with treatment group(P < 0.05). In table 4.
Blood glucose value comparison before and after table 4 liang group treatment
Note: with treatment group comparison★★P<0.01，★P < 0.05, relatively front with treatment▲▲P<0.01，▲P<0.05
Conclusion, the present composition has a better role to diabetes B hyperlipidemia, energyEffectively reduce serum total cholesterol, triglycerides, increasing high density lipoprotein, improves diabetesFat metabolic disturbance state, and have certain auxiliary hyperglycemic effect.
Claims (9)
1. a composition with auxiliary hyperglycemic effect, is characterized in that: raw material components is 100 parts～300 parts, highland barley, 100～300 parts of emblics, 100 parts～300 parts, turmeric, 50 parts～150 parts of rhizoma zingiberis, 50 parts～150 parts of sea-buckthorns, 50 parts～150 parts, bent letter.
2. composition according to claim 1, is characterized in that: described raw material consists of 200 parts, highland barley, 200 parts of emblics, 200 parts, turmeric, 100 parts of rhizoma zingiberis, 100 parts of sea-buckthorns, 100 parts, bent letter.
3. the composition described in claim 1 or 2 is in the application of preparing in health food and/or functional food and/or medicine.
4. application according to claim 3, is characterized in that: described health food and/or functional food and/or medicine are for the health food of diabetes-alleviating hyperglycaemia symptom and/or functional food and/or medicine.
5. contain health food and/or functional food and/or the medicine of the composition described in claim 1 or 2.
6. health food according to claim 5 and/or functional food and/or medicine, is characterized in that: be oral class.
7. the method for preparation health food claimed in claim 5 and/or functional food and/or medicine, it is characterized in that: each raw material components is prepared in proportion, according to traditional patent medicine processing method, add if desired acceptable auxiliary material in pharmacy to be prepared into different dosage form.
8. method according to claim 7, is characterized in that: be one of following method:
Method one: choose raw material and prepare to scale; Highland barley frying, pulverized 100 mesh sieves, made highland barley flour stand-by; Except highland barley, all the other raw materials add 10 times of water gagings of weight, soak 1h, and 98 DEG C～100 DEG C decoct 2h, filter, and collect the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C～100 DEG C decoct 1h, filter, and merge twice filtrate, and spraying is dry; Add highland barley flour, mix, obtain composition powder; Resulting composition powder, wet granulation, dry, whole grain, compressing tablet, dressing, to obtain final product;
Method two: choose raw material and prepare to scale; Highland barley frying, pulverized 100 mesh sieves, made highland barley flour stand-by; Except highland barley, all the other raw materials add 10 times of water gagings of weight, soak 1h, and 98 DEG C～100 DEG C decoct 2h, filter, and collect the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C～100 DEG C decoct 1h, filter, and merge twice filtrate, and spraying is dry; Add highland barley flour, mix, obtain composition powder; Resulting composition powder, dry, pulverizing, sieves, and filled capsules, to obtain final product;
Method three: choose raw material and prepare to scale; Raw material adds 10 times of water gagings of weight, soaks 1h, and 98 DEG C～100 DEG C decoct 2h, filter, and collects the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C～100 DEG C decoct 1h, filter, and merge twice filtrate, and filtrate is concentrated into medicinal material than for 1:10, and concentrate seasoning, adds purified water, and filtration, filling, hot pressing steam sterilizing, packaging, to obtain final product.
9. method according to claim 8, is characterized in that: in described method three, concentrate adds honey, white granulated sugar, citric acid, potassium sorbate, purified water, filters, filling, hot pressing steam sterilizing, packaging, to obtain final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3978005A4 (en) * | 2019-05-30 | 2023-03-15 | HLscience Co., Ltd | Composition for preventing, alleviating or treating metabolic syndrome accompanied by obesity and/or diabetes, containing, as active ingredient, complex (ib complex) of indian gooseberry extract and sprout barley extract |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770715A (en) * | 2014-12-19 | 2016-07-20 | 北京宝德润生医药科技发展有限公司 | Composition with blood sugar lowering function, and preparation method thereof |
| CN108619483B (en) * | 2018-05-22 | 2020-01-14 | 广州人为峰生物科技有限公司 | A biological protein extracted from pupa Bombycis for lowering blood sugar and balancing dietary nutrition |
| CN110419726A (en) * | 2019-08-28 | 2019-11-08 | 宇妥藏药股份有限公司 | A kind of highland barley meal replacement powder and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899472A (en) * | 2006-07-04 | 2007-01-24 | 洛嘎 | Night oral administration Tibet medicine for treating diabetes and its preparing method |
| CN101700397A (en) * | 2009-11-10 | 2010-05-05 | 尼玛次仁 | Tibetan medicine composite for treating diabetes and preparation method of preparation thereof |
| CN102872334A (en) * | 2012-10-29 | 2013-01-16 | 山东阿如拉药物研究开发有限公司 | Application of medicinal composition for treating diabetes mellitus |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899472A (en) * | 2006-07-04 | 2007-01-24 | 洛嘎 | Night oral administration Tibet medicine for treating diabetes and its preparing method |
| CN101700397A (en) * | 2009-11-10 | 2010-05-05 | 尼玛次仁 | Tibetan medicine composite for treating diabetes and preparation method of preparation thereof |
| CN102872334A (en) * | 2012-10-29 | 2013-01-16 | 山东阿如拉药物研究开发有限公司 | Application of medicinal composition for treating diabetes mellitus |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3978005A4 (en) * | 2019-05-30 | 2023-03-15 | HLscience Co., Ltd | Composition for preventing, alleviating or treating metabolic syndrome accompanied by obesity and/or diabetes, containing, as active ingredient, complex (ib complex) of indian gooseberry extract and sprout barley extract |
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