CN102526479B - Health-care medicine formula with functions of enhancing immunity and lowering blood sugar - Google Patents

Health-care medicine formula with functions of enhancing immunity and lowering blood sugar Download PDF

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CN102526479B
CN102526479B CN2011103543716A CN201110354371A CN102526479B CN 102526479 B CN102526479 B CN 102526479B CN 2011103543716 A CN2011103543716 A CN 2011103543716A CN 201110354371 A CN201110354371 A CN 201110354371A CN 102526479 B CN102526479 B CN 102526479B
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mice
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CN102526479A (en
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李�杰
施建耀
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NINGBO HAIYI BIOTECHNOLOGY CO Ltd
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Abstract

The invention discloses a health-care medicine with functions of enhancing immunity and lowering blood sugar, which is characterized by comprising the following ingredients: 11g of broccoli extract, 7g of bitter gourd extract, 9g of rhizoma polygonati, 8g of folium mori extract, 4.1g of the fruit of Chinese wolfberry, 7.8g of the root of kudzu vine, 8.5g of microcrystalline cellulose, 8.5g of xylitol, 4.2g of mannite and 0.68g of Sucralose. The effective ingredients are distributed as below: 100g medicine contains effective ingredients, namely 375mg of thioglycol, 15g of polysaccharide, 5g of total saponins, and 6g of flavones. The health-care medicine formula with the functions of enhancing immunity and lowering blood sugar can help people to enhance the immunity, lower blood sugar, improve the immunity of the human body and improve the quality of life of patients with high sugar blood and does not have side effect or adverse reaction. Because of adopting the modern preparation technology and an advanced quality control method, the product is safe and stable and has controllable quality.

Description

The health medicine of a kind of enhancing immunity, function of blood sugar reduction
Technical field:
The present invention relates to the health medicine of a kind of enhancing immunity, function of blood sugar reduction.
Background technology:
Over more than 50 year, diabetes have developed into the global problem of harm humans health, social and economic development.Total number of persons every year of diabetics, the speed with more than 700 ten thousand increased progressively.If do not take any measure, 3.5 hundred million populations that surpass that will affect in a generation are wreaked havoc in the whole world of diabetes so.If diabetes are treated in passiveness, it may threaten the Health Care Services of many countries so, and engulfs the economic development achievement of developing country." according to the report of World Health Organization (WHO), l998 whole world diabetics adds up to 1.43 hundred million people, expects 2025 and will rise to 300,000,000 people, wherein developed country will increase by 45%, and developing country will increase by 200%.
Along with China's expanding economy, the improvement of people's lives, the people of Overweight and obesity increases, and the middle-aged and elderly people diabetes more than 40~50 years old also increase year by year.China's diabetics at present surpasses more than 3,000 ten thousand, and the trend increased is year by year arranged, and the people that the blood glucose toleration is low in addition nearly 2,000 ten thousand.For developing country, cure the disease and can bring heavier burden, so diseases prevention just seems and is even more important.
Many people can not note nutritious food, often ignore the food that those cholesterol are higher, and cause that blood glucose is high.Under normal circumstances, human body can guarantee that the source of blood glucose and outlet keep balance, make blood glucose maintain certain level by hormonal regulation and this two large regulating system of neuroregulation.But, under the combined effect of inherited genetic factors (as the diabetes family history) and environmental factors (as irrational meals, obesity etc.), two large regulatory functions get muddled, and just there will be the rising of blood sugar level.Long-term hyperglycemia can make each histoorgan generation pathological changes of whole body, causes the generation of acute and chronic complication.As pancreatic function exhaustion, dehydration, electrolyte disturbance, malnutrition, resistance decline, impaired renal function, neuropathy, retinopathy etc.The control hyperglycemia is imperative.The mankind's healthy living, closely related with stablizing of external environment (as air, water source) and interior environment (as blood, tissue fluid).The too high interior environment that has destroyed just human body of blood glucose, cause a series of biochemical pathological changes, affected the function of each internal organs.As can be seen here, sugared friend should be under doctor's guidance, positively by glucostasis at normal level, prevent or delay the generation of complication.Diabetes are a kind of syndromes due to the caused glucose of cellular metabolism effect defect, protein and the lipid metabolic disorder of insufficient insulin or insulin.It is characterized in that in blood glucose content abnormal raise and urine in glucose appears.Typical three-many-one-little symptom can appear when blood glucose is too high, that is: polyuria, polydipsia, polyphagia and lose weight, and with fatigue and weak.Ketoacidosis and hyperosmolar coma can occur in severe patient, and merge multi-infection, and with the prolongation of the course of disease, metabolism disorder can cause the chronic complicating diseases of the histoorgans such as eye, kidney, the heart, blood vessel, nerve.
Chinese medicine was through the development of more than 2000 years, and extensive knowledge and profound scholarship, in recent years, take Chinese medical theory as guidance, adopted modern science and technology, the Chinese medicine preparation of a large amount for the treatment of of development diabetes.The Chinese medicine preparation of the treatment type 2 diabetes mellitus recorded in the Pharmacopoeia of the People's Republic of China and " mark promulgated by the ministries or commissions of the Central Government is difficult ".New Chinese medicine preparation is all obtained certain achievement in pharmacodynamics, clinical research in recent years.
China is engaged in research and the production of natural drug, advantageous condition is arranged, the rarity of Traditional Chinese Medicine, it has the clinical experience of several thousand, from current pharmaceutical research trend, find new drug or find that the guide is combined to thing and it is carried out to the important content that structural modification is drug development from natural product, along with the people that day by day seriously make of social environmental pollution more and more like pure natural, pollution-free, the food that do not add synthetics.Adding growth in the living standard also makes people, to the quality of life, higher pursuit arranged.Under this background, this formula uses the hypoglycemia healthcare food that high-tech means the free of contamination pure natural animals and plants of take are raw material to arise at the historic moment, and develop rapidly.
Summary of the invention:
The formula of health-care medicine that the purpose of this invention is to provide a kind of enhancing immunity, function of blood sugar reduction, it can strengthen people's immunity, auxiliary people's auxiliary hyperglycemic, improve people's living standard, have no side effect and untoward reaction, and use modern preparation technique, advanced method of quality control, make product accomplish safety, stable, quality controllable.
In order to solve the existing problem of background technology, the present invention is by the following technical solutions: its recipe ratio is: Caulis et Folium Brassicae capitatae 4.5-15g, Fructus Momordicae charantiae extract 3-9g, Rhizoma Polygonati 4.5-12g, Folium Mori extract 4.5-12g, Fructus Lycii 3-5g, Radix Puerariae 4.5-12g, microcrystalline Cellulose 3-10g, xylitol 3-10g, mannitol 3-5g, sucralose 0.4-1g; First Rhizoma Polygonati, Fructus Lycii, Radix Puerariae medicine are pulverized respectively, cross the 80-100 sieve, get respectively the weighing by a certain percentage of its powder and Caulis et Folium Brassicae capitatae, Fructus Momordicae charantiae extract, Folium Mori extract, microcrystalline Cellulose, xylitol, mannitol, sucralose, mixed again, mixed 45 minutes (guaranteeing mix homogeneously), then carried out tabletting (sheet is heavily controlled by inner quality standard), screened again, polishing, carry out again inner packing, then carry out outer package, finally the check warehouse-in; Within whole course of processing environment is controlled 25 ℃ of left and right of temperature, humidity 35%.
The present invention has following beneficial effect: immunity, the assisting in reducing blood sugar symptom that can strengthen the people, improve people's health level, have no side effect and untoward reaction, and use modern preparation technique, advanced method of quality control, make product accomplish safety, stable, quality controllable.
The specific embodiment:
This specific embodiment is by the following technical solutions: its recipe ratio is: Caulis et Folium Brassicae capitatae 4.5-15g, Fructus Momordicae charantiae extract 3-9g, Rhizoma Polygonati 4.5-12g, Folium Mori extract 4.5-12g, Fructus Lycii 3-5g, Radix Puerariae 4.5-12g, microcrystalline Cellulose 3-10g, xylitol 3-10g, mannitol 3-5g, sucralose 0.4-1g.
Preferred implementation is that recipe ratio is: Caulis et Folium Brassicae capitatae 4.5g, Fructus Momordicae charantiae extract 3g, Rhizoma Polygonati 4.5g, Folium Mori extract 4.5g, Fructus Lycii 3g, Radix Puerariae 4.5g, microcrystalline Cellulose 3g, xylitol 3g, mannitol 3g, sucralose 0.4g;
Another preferably embodiment be that recipe ratio is: Caulis et Folium Brassicae capitatae 15g, Fructus Momordicae charantiae extract 9g, Rhizoma Polygonati 12g, Folium Mori extract 12g, Fructus Lycii 5g, Radix Puerariae 12g, microcrystalline Cellulose 10g, xylitol 10g, mannitol 5g, sucralose 1g;
Best a kind of embodiment is: Caulis et Folium Brassicae capitatae 11g, Fructus Momordicae charantiae extract 7g, Rhizoma Polygonati 9g, Folium Mori extract 8g, Fructus Lycii 4.1g, Radix Puerariae 7.8g, microcrystalline Cellulose 8.5g, xylitol 8.5g, mannitol 4.2g, sucralose 0.68g;
Effective ingredient distributes as follows: the 100g medicine is containing the sweet 375mg of effective composition sulfur, polysaccharide 15g, total saponins 5g, flavone 6g.
In addition, a kind of method that configures said medicine also is provided, first Rhizoma Polygonati, Fructus Lycii, Radix Puerariae medicine are pulverized respectively, cross the 80-100 sieve, get respectively the weighing by a certain percentage of its powder and Caulis et Folium Brassicae capitatae, Fructus Momordicae charantiae extract, Folium Mori extract, microcrystalline Cellulose, xylitol, mannitol, sucralose, mixed again, mix 45 minutes (guaranteeing mix homogeneously), then carry out tabletting (sheet is heavily controlled by inner quality standard), screened again, polishing, carry out again inner packing, then carry out outer package, finally the check warehouse-in; Within whole course of processing environment is controlled 25 ℃ of left and right of temperature, humidity 35%.
The present invention has following beneficial effect: immunity, the assisting in reducing blood sugar symptom that can strengthen the people, improve people's health level, have no side effect and untoward reaction, and use modern preparation technique, advanced method of quality control, make product accomplish safety, stable, quality controllable.
Caulis et Folium Brassicae capitatae:
Caulis et Folium Brassicae capitatae has another name called broccoli, blue and white Lay, sprouting broccoli etc., belongs to the mutation that the Cruciferae Caulis et Folium Brassicae campestris belongs to brassica specie, is one, the biennial herb plant, originates in Italy.Have and experimental results show that Caulis et Folium Brassicae capitatae contains abundant cancer-resisting substance and can lower the formation to the mouse breast tumor, stop the activity [5] of carcinogen.Scientist finds that the anti-cancer material in the brassicaceous vegetables such as Caulis et Folium Brassicae capitatae is enzymatic hydrolysate or the derivant of thioglycoside, wherein isothiocyanate class most importantly.
Glucorphanin is a kind of of thioglycoside, extensively is present in Caulis et Folium Brassicae capitatae, and glucorphanin produces isothiocyanate through myrosinase enzymolysis or acid hydrolysis: sulforaphen.Sulforaphen is the strongest anti-cancer active matter of finding in vegetable up to now, because it finds to gain the name in Radix Raphani [6].The foreign son professor of Japan nutritionist good fortune man waits and passes through verification experimental verification: in the crucifers such as Brassica oleracea L.var.capitata and Caulis et Folium Brassicae capitatae, contained isothiocyanic acid ester derivant sulforaphen has treatment cancer and the effectiveness of killing leukocyte, and this is to confirm that for the first time it has the effect of killing the leukaemia [6].Show according to the study in the fresh Caulis et Folium Brassicae capitatae of freshly harvested that glucorphanin (3-methylsulfinyl acrylic thioglycoside) and Glucoraphanin account for 78% of total glucosinolate content.Under common content, glucorphanin and its catabolite have important benefits to health, although glucorphanin is not direct beneficial organism active substance, its hydrolyzate sulforaphen has the defencive function that strengthens human body.
The relation of sulforaphen and immunocompetence is mainly [7]: external having studies have shown that sulforaphen has the function that improves immunity.Experiment shows: within continuous 9 days, give BALB/c (4-6 age in week) mouse every day (every of 500ug/) feed sulforaphen, within the 9th day, the total leukocyte counting is strengthened one times of amount, the quantity of medullary cell and esterase A positive cell has also increased by one times, the hemolysis plaque number obviously raises, the synthetic antibody number obviously increases, and sulforaphen has also improved the activate the phagocytic capacity of peritoneal macrophage.Radix Raphani sulfur greatly reduces the higher leveled TNF-a produced by LPS (endotoxin) stimulating expression of macrophage in addition.These results show, sulforaphen improves immunity and auxiliary obesity is improved microenvironment successful in body.
Through zoopery, show in addition: sulforaphen is remarkable in the effect of anti-tumor aspect.Sulforaphen after taking food to mouse high dose (μ mol/kg every days 100) continuously in 4-5 days, and in mouse liver, lung, mammary gland, pancreas, stomach, small intestinal and colon, the activity of II phase detoxication enzyme all is improved [8].Munday etc. [9]compared the ability that six kinds of ITCs induce the Phase II detoxication enzymes such as QR (quinone reductase), GST (glutathione transferase) in the mouse Different Organs.Test dose is μ mol/kg every days 40, and feeding is 5 days continuously.Result shows that all ITCs have shown the activity of inducing QR and GST in duodenum, stomach, bladder, and wherein sulforaphen induces the activity of GST the strongest in duodenum and bladder, and in all organs, the effect with bladder is the most remarkable again.Jackson etc. [10]the research discovery, the F311 breast cancer cell to the BALB/c mouse when sulforaphen reaches 15nmol/L concentration has inhibitory action, within continuous 13 days, gives BALB/c mouse injection 15nmol/d, the sulforaphen of concentration, the F311 breast cancer cell of mouse reduces about 60%.
Above experimental data proof sulforaphen has significant raising immunity and antitumor efficacy, but because sulforaphen itself is very unstable, this product adopts its prerequisite glucorphanin as main component, take glucorphanin through the zoopery proof, become sulforaphen through enzymolysis in animal body, can reach and directly take the effect that sulforaphen is identical, and product is more stable.
This product, through acute toxicology, nursing experiment in 30 days, any side effect and untoward reaction all do not occur.This product adopts ethanol and water to extract from the vegetable Caulis et Folium Brassicae capitatae in addition, there is no other pollution.The dosage adopted, in usual Caulis et Folium Brassicae capitatae vegetable edible range.Show that this prescription is feasible, there is good using value.
Fructus Momordicae charantiae
The fruit of the annual herbaceous plant Fructus Momordicae charantiae of overgrowing of Fructus Momordicae charantiae section Momordica, the history of being used as medicine of Fructus Momordicae charantiae is very long, and in Asia, all there is the record of being used as medicine many countries and regions.Compendium of Material Medica is listed in dish section dish class, day: the “Ku Qu Junyou record of being used as medicine.Compendium of Material Medica is listed in dish section dish class, day: " bitter cold is nontoxic, except pathogenic heat, separates tiredly, and improving eyesight clears away heart-fire." a large amount of modern studies are cold nontoxic, except pathogenic heat, separate tiredly, improving eyesight clears away heart-fire." a large amount of modern study results show; Fructus Momordicae charantiae contain the number of chemical composition and there is blood sugar lowering, resistive connection really shows, Fructus Momordicae charantiae contains the number of chemical composition and has blood sugar lowering, antioxidation, raising immunity, reduces cholesterol, anti AIDS virus and anti-swollen oxidation, improves immunity, reduces the multiple significant physiologically actives such as cholesterol, anti AIDS virus and antitumor.Fructus Momordicae charantiae extract the multiple significant physiologically actives such as angioma fall.The hypoglycemic activity of Fructus Momordicae charantiae extract, more and more be subject to people's attention.Pharmacology is in recent years ground the sugar effect, more and more is subject to people's attention.Pharmacological research in recent years shows, the balsam pear hypoglycemic effect is that the coefficient knot of Multiple components is studied carefully and shown, the balsam pear hypoglycemic effect is the coefficient result of Multiple components.
1, bitter gourd polypeptide to P2 the blood sugar reducing function to normal mouse and diabetic mice
Fructus Momordicae charantiae is rich in bitter gourd polypeptide, bitter gourd polypeptide P2 proves in Table 1. results the blood sugar reducing function of normal mouse and diabetic mice, bitter gourd polypeptide can reduce the blood glucose of normal mouse and alloxan diabetes model mice, and type 2 diabetes mellitus is had to certain function of blood sugar reduction.
The blood sugar reducing function of table 1 bitter gourd polypeptide P2 to normal mouse and diabetic mice
2, the impact of CPS on normal mouse oral glucose tolerance (OTGG)
Result shows, CPS can significantly improve the normal mouse glucose tolerance, the area under curve experimental group significantly is less than matched group, matched group 0.5h, 1h blood glucose after the glucose gavage 167% and that raises respectively, and experimental group only raises 120% and 46%, two groups of comparison difference have significant (P<0.05), and after administration 2h, two treated animal blood glucose reach quite level.
The impact of table 2CPS on normal glucose tolerance in mice
Figure GSB0000113276770000071
Annotate: with matched group, compare * P<0.05, * * P<0.01
3, the impact of CPS on random feed type 1 diabetes mouse blood sugar
CPS is on the impact of random feed type 1 diabetes mouse blood sugar from table 3, and CPS has remarkable reducing effect to random feed type 1 diabetes mouse blood sugar, and its hypoglycemic activity is gone back highly significant after administration after 4h.Matched group 2h, 4h blood glucose after administration descend respectively 3% and 19%, and experimental group descends respectively 21% and 42%.
The effect of table 3CPS to random feed type 1 diabetes mouse blood sugar
Figure GSB0000113276770000072
Annotate: with matched group, compare * P<0.05, * * P<0.01
4, the impact of CPS on random feed type 2 diabetes mellitus mouse blood sugar
CPS is on the impact of random feed type 2 diabetes mellitus mouse blood sugar in Table 4 demonstrations, and matched group 2h, 4h blood glucose after administration descend respectively 4% and 14%, and experimental group blood glucose 25% and 38%, the two group of comparison difference that descends respectively has significant.
The effect of table 4 pair random feed type 2 diabetes mellitus mouse blood sugar
Figure GSB0000113276770000073
Figure GSB0000113276770000081
Annotate: with matched group, compare * P<0.05
5, the effect of CPS to each type 1 diabetes mice fasting glucose
CPS is to the effect of each type 1 diabetes mice fasting glucose in Table 5, and result shows, GPS has remarkable reducing effect to type 1 diabetes mice fasting glucose.Matched group 2h, 4h blood glucose after administration descend respectively 11% and 31%, and experimental group blood glucose descends respectively 46% and 62%.
The effect of table 5 pair random feed type 1 diabetes mouse blood sugar
Figure GSB0000113276770000082
Annotate: with matched group, compare * P<0.05, * * P<0.01
6, the effect of CPS to type 2 diabetes mellitus mice fasting glucose
The effect of CPS to type 2 diabetes mellitus mice fasting glucose in Table 6, shows that CPS can significantly reduce, type diabetic mice fasting glucose.Matched group 2h, 4h blood glucose after administration descend respectively 7% and 19%, and experimental group blood glucose 24% and 38%, the two group of fall comparison difference that descends respectively has significant.
The impact of table 6CPS on type 2 diabetes mellitus mice fasting glucose
Figure GSB0000113276770000083
Annotate: compare * P<0.05 with matched group,
This research shows the carbohydrate tolerance experimental result of normal mouse, and after disposable per os gives CPS0g/kg bw, the experimental group blood sugar level is at 0.5h, 1h all significantly lower than matched group, and prompting CPS has the effect that reduces Postprandial peak glucose.While giving type 1 diabetes and type 2 diabetes mellitus mice Fructus Momordicae charantiae CPS1g/kg bw dosage, no matter be fasting glucose or random blood sugar, significant decline is arranged, show that CPS can reduce, plant fasting glucose and the random blood sugar of diabetic mice.Have multiple sugar-lowering components in Fructus Momordicae charantiae, except glycoside, also have alkaloid and a kind of similar insulinoid polypeptide compound, the mechanism of action mainly contains the para-insulin effect, stimulates β emiocytosis insulin and the effect of protection pancreas.Former studies shows that polysaccharide also has rheological characteristic and the Platelet that improves blood, reduces whole blood viscosity, improves systemic microcirculation and tissue metabolism's level, indirectly plays the effect that improves pancreatic beta cell type function.Bitter melon polysaccharide has antioxidation, immunoregulation effect, can repair impaired pancreas, reduces the oxidative stress level that the diabetes hyperglycemia causes.Originally studies show that CPS has significant blood sugar reducing function to normal mouse and 2 kinds of diabetes models.
Rhizoma Polygonati
The rhizome that Rhizoma Polygonati is liliaceous plant Rhizoma Polygonati, Polygonatum cyrtonema Hua, for " Chinese pharmacopoeia is recorded kind, begins to be stated from that " Mingyi Bielu press medical material shape difference, practises respectively and is called " polygonatum sibiricum Redoute ", " RHIZOMA POLYGONATI ZINGIBERIFORME ", " Rhizoma Polygonati greatly ".Rhizoma Polygonati sweet in the mouth, property are flat, return spleen, lung, kidney channel, the function such as have spleen invigorating, the kidney invigorating, lung moistening, promote the production of body fluid." Mingyi Bielu " classified it as top grade, claim Rhizoma Polygonati " invigorating the spleen and replenishing QI, for a long time clothes make light of one's life by commiting suicide prolong life not hungry." research show, Rhizoma Polygonati and effective ingredient thereof have pharmacological action widely.Polygonatum polysaccharide has no significant effect normal mouse blood sugar level, but can significantly reduce the blood glucose value that kidney is foretold the hyperglycemia mice that parathyrine brings out, and reduces the content of cyclic adenosine monophosphate in the adrenaline model mice liver (cAMP) simultaneously.Li Youyuan etc. study discovery, and polygonatum polysaccharide can show artificial diabetes Mus blood glucose and serum glycolated hemoglobin concentration, and obviously raise plasma insulin and c peptide level.Polygonatum polysaccharide may be the inhibitor of glycosylation damage, can reduce blood sugar level by the secretion that promotes insulin and C peptide, therefore has higher development and utilization and is worth.Zhang Hong etc. treat type ii diabetes with the single medicinal material Rhizoma Polygonati, can better control diabetes patient's blood glucose.The impact of the emphasis polygonatum polysaccharide on tentative hyperglycemia model mouse blood sugar, and its mechanism has been done to preliminary analysis.
1, the impact of PSP on normal mouse blood sugar
From table 7, the large, medium and small dosage group of PSP is not obvious on normal mouse blood sugar impact, with Normal group, compares, and is P>0.05.But positive controls can significantly reduce the normal mouse blood sugar level, with Normal group, compare P<0.01.
The impact of table 7PSP on normal mouse blood sugar
Figure GSB0000113276770000101
Figure GSB0000113276770000102
Annotate: with the Normal group ratio, annotate: * P<0.01,
2, the impact of PSP on AD model mice blood glucose
From table 8, PSP model mice blood glucose obviously raises, and compares P<0.01 with Normal group.Positive controls can be resisted the pathoglycemia caused by Ad, with the model group mice, compares, and hypoglycemic activity is (P<0.01) significantly.The heavy dose of group of PSP mouse blood sugar level obviously reduces, and with model group, compares, and P<0.05, significantly reduce with dosage group mouse blood sugar level in PSP, with model group, compares, and compare with the heavy dose of group of PSP P<0.01, and there were significant differences (P<0.05); The PSP small dose group has the trend (P>0.05) that reduces blood sugar level.
The impact of table 8 on PSP model mice blood glucose
Figure GSB0000113276770000103
Figure GSB0000113276770000104
Figure GSB0000113276770000111
Annotate: with Normal group ratio, * P<0.01; With model group ratio, △ P<0.05,
△ △ p<0.01; With the heavy dose of group of PSP ratio, * * P<0.05
3, the impact of PSP on cAMP content in liver
From table 9, in Ad model mice liver, the content of cAMP significantly increases, and compares P<0.01 with Normal group.Positive drug glyburide can reduce the content (P<0.01) of cAMP in the model mice liver.
The heavy dose of group of PSP can reduce the content (P<0.05) of cAMP in the model mice liver, in PSP, the dosage group can significantly reduce the content (P<0.01) of cAMP in the model mice liver, but relatively there is no difference (P<0.05) between two groups, the content not impact (P>0.05) of PSP small dose group on cAMP in the model mice liver.
The impact of table 9PSP on cAMP content in Ad model mice liver
Figure GSB0000113276770000112
Annotate: with Normal group ratio, △ P<0.01; With model group ratio, * P<0.05, * * P<0.01
In a word, cAMP is the important active substances of body, participates in multiple metabolic process, plays a part " second message,second messenger " in Neuroendocrine regulation, is controlling the composition and decomposition of hepatic glycogen, is to maintain a constant key factor of body blood glucose.Therefore, this experimental selection normal mouse and Ad model mice are object of study, inquire into the relation of polygonatum polysaccharide hypoglycemic activity and cAMP.The experimental result prompting: 1. polygonatum polysaccharide has no obvious effect to normal mouse blood sugar level.This point shows, polygonatum polysaccharide is natural drug, is different from general chemical synthetic drug, and when organismic internal environment is stablized, its impact is often not remarkable, and polygonatum polysaccharide does not disturb normal carbohydrate metabolism process.2. polygonatum polysaccharide can significantly reduce the blood glucose value of the hyperglycemia mice that epinephrine brings out.Epinephrine, by excited α, beta receptor, promotes that hepatic glycogen decomposes, lipid mobilization, thus rising blood glucose.This experiment shows, polygonatum polysaccharide has sure reducing effect to abnormal blood glucose, and with dosage, does not strengthen, and dosage is that the 500mg/kg hypoglycemic activity is the most obvious, can promote the use of clinically.3. polygonatum polysaccharide obviously reduces the content of cAMP in Ad model mice liver, thereby infer that its hypoglycemic activity mechanism is to have reduced the content of cAMP in hepatocyte, activate and the glycogen synthetase inactivation thereby hinder acidifying enzyme, cause the synthetic acceleration of glycogen, glycogenolysis to slow down.The mechanism that polygonatum polysaccharide reduces cAMP may affect the expression of adrenoceptor or cause that the conformational change of receptor is relevant with it.
Folium Mori
Folium Mori are leaves of moraceae plants Mulberry, according to Compendium of Material Medica, put down in writing: " Folium Mori are the medicine of brothers Yang Ming. juice is decocted Dai Ming.Can only quench one's thirst. the item long hair." China's successive dynasties all useful Folium Mori control the record of diabetes.Recent study is bright, Folium Mori are rich in polysaccharide, flavone, alkaloid, protein, aminoacid, the rope of supporting one's family, trace element isoreactivity composition, there is the effects such as blood sugar lowering, blood fat reducing, anti-stress, defying age, anticoagulation, and flavones in mulberry leaves claims that FM is one of main composition of its hypoglycemic activity.For this reason, flavones in mulberry leaves research to effects such as alloxan diabetes mice adjusting blood glucose, carbohydrate tolerance test, body weight, liver body compare by it.To inquire into the FM hypoglycemic activity.For clinical practice and the development of resources of Folium Mori provides foundation.Contain the various active compositions such as flavonoid compound, volatile oil, aminoacid and polysaccharides of Folium Mori in Folium Mori; Pharmacology is ground the effect that the proof Folium Mori have inhibition blood glucose Bu Sheng now, can prevent to treat diabetes.
1, the affect result of flavones in mulberry leaves on the blood glucose in diabetic mice value.
The body experimental session.Model control group mice fasting blood sugar continue to raise. with significant differences (p<0.01) is more all arranged before administration, and reach peak at experiment 4th week end.Experimental result according to dosage classification: 1. high dose group mice, along with the experiment process, its blood glucose value reduces gradually, level before experiment is starkly lower than administration 6 weekends; At administration 2,4 and 6 weekends. with model control group, significant difference (p<0.05 or P<0.01) is more all arranged; And.Testing for 6 weekends. blood glucose value and Normal group be there was no significant difference relatively.2. middle dosage group mice, at administration 2 and 4 weekends, blood glucose value slightly raises. but with administration before relatively all without significant difference is arranged; At experiment blood glucose value at 6 weekend, obviously reduce.And, testing for 4 and 6 weekends, with model control group, significant differences is more all arranged.3. low dose group mice, at administration 2 and 4 weekends, blood glucose value continues to raise, and significant difference is more all arranged before administration; Obviously fall after rise at experiment blood glucose value at 6 weekend, and testing for 4 and 6 weekends.With model control group, significant difference is more all arranged.The contrast experiment shows flavones in mulberry leaves control diabetic mice fasting blood sugar rising successful, has the effect that reduces its blood glucose value.There is certain dosage one reaction relation.In Table 10
The impact of table 10 flavones in mulberry leaves on the blood glucose in diabetic mice value
Figure GSB0000113276770000131
Figure GSB0000113276770000132
Annotate: with model control group ratio, * P<0.01, * * P<0.01; Compare △ △ P<0.01 before administration
2, the affect result of flavones in mulberry leaves on the experiment of diabetic mice carbohydrate tolerance
In Table 11,3 dosage group mouse blood sugar area under curve, all lower than model control group, and middle and high dosage group and model control group are relatively, and its difference all has significant (P<0.05 or P<0.01).Show that flavones in mulberry leaves has the effect of obvious reduction blood glucose in diabetic mice area under curve.
The impact of table 11 flavones in mulberry leaves on the experiment of diabetic mice carbohydrate tolerance
Annotate: with model control group ratio, * P<0.05, * * P<0.01
3, flavones in mulberry leaves on the diabetic mice body weight affect model control group and 3 dosage group Mouse Weights all obviously alleviate after modeling, with before modeling relatively, be very significant (P<0.01).At experimental session. each organizes the Mice Body weight average certain rise.But the model control group Mouse Weight is starkly lower than Normal group always.In 3 dosage groups. along with the increase of dosage, body weight gain is obvious, and high dose group rises in 2 weeks after administration, low, middle dosage group after administration 3 Zhou Qijun apparently higher than level before modeling; And the most obvious with the high dose group body weight gain, after administration, 2 Zhou Qijun are apparently higher than model control group.Significant difference is all arranged.And compare difference that there are no significant with Normal group.Show that flavones in mulberry leaves has the effect that promotes the diabetic mice weight recovery.And have certain dosage one reaction relation, in Table 12.
The impact of table 12 flavones in mulberry leaves on the diabetic mice body weight
Figure GSB0000113276770000143
Figure GSB0000113276770000144
Annotate: with model control group, compare .*P<0.05, * * P<0.01; With comparison before modeling, △ P<0.05, △ △ P<0.01; Compare ☆ P<0.05, ☆ ☆ P<0.01 with Normal group
4, the impact of flavones in mulberry leaves on diabetic mice internal organs weight and dirty body ratio, in Table 13
The impact of table 13 flavones in mulberry leaves on diabetic mice internal organs weight and dirty body ratio
Figure GSB0000113276770000152
Figure GSB0000113276770000153
Annotate: model control group is .*P<0.05 relatively, * * P<0.01; Compare ☆ P<0.05, ☆ ☆ P<0.01 with Normal group;
4.1 liver: model control group and 3 dosage group mouse liver weight averages are higher than Normal group, but there are no significant difference.3 dosage group Mouse Liver bodies are than all lower than model control group, and low, its difference of high dose group all has significant (P<0.05 or P<0.01); And model control group and 3 dosage group Mouse Liver bodies compare all apparently higher than Normal group, its difference all has significant.
4.2 kidney: the heavy and kidney body of model control group and 3 dosage group mouse kidneys compares all apparently higher than Normal group, and its difference is very significant (P<0.01); 3 dosage group Mouse Kidney bodies compare all lower than model control group, and high dose group and model control group comparison, and its difference is very significant.Each organizes the heavy and spleen body of the mouse spleen difference that compares that there are no significant.Experiment shows diabetic mice liver body ratio, kidney is heavy and the kidney body increases than all, and flavones in mulberry leaves has the effect that makes its reduction.
Alloxan is a kind of B cytotoxic agent, optionally damages the beta Cell of islet of many animals, causes artificial diabetes.This research be take the alloxan diabetes model mice as object, if flavones in mulberry leaves 0.25,0.50,3 dosage groups of 1.00gkg-1 body weight, separately establish a diabetes model matched group and a Normal group is intervened test, result shows that alloxan diabetes mice " three-many-one-little " symptom is fairly obvious; Liver body ratio, kidney weight and kidney body are than all increasing.Along with increasing of flavones in mulberry leaves dosage. alloxan diabetes mice symptom is alleviated gradually; Fasting blood sugar and Area under the curve of blood glucose obviously reduce; Body weight gain is obvious. and liver body ratio, kidney weight and kidney body are than all having certain reduction, above indices all to have certain dosage one reaction relation.This experimental result shows that flavones in mulberry leaves has obvious reduction blood glucose.Improve the effect of diabetic symptom.
Fructus Lycii
Fructus Lycii is the rare Chinese medicine of the traditional dietotherapeutic of China, and its sweet in the mouth, property are put down, and have the function of invigorating the liver and kidney, benefiting essence-blood and improving eyesight, in recent years, are subject to Medical Technologist and dietetic therapy expert's great attention always.The pharmacology of Fructus Lycii and health-care effect and the bioactive substance lycium barbarum polysaccharide wherein contained have much relations.Modern scientific research shows, lycium barbarum polysaccharide has the immunity of adjusting, removes free radical, suppresses tumor, slow down aging, blood fat reducing, blood sugar lowering and fatigue-resisting function, has wide development prospect.
1, antifatigue effect Lee state jasmine etc. be take oxidative Ability of Sport Training Mouse as animal model, has investigated the impact of lycium barbarum polysaccharide on activities of antioxidant enzymes in Endurance and body.Result shows.LBP can obviously extend mice and exhaust swimming time, improve the endurance of exercised rats, can obviously improve the activity of mice plasma, muscular tissue, hepatic tissue SOD and GSH.Px, thereby be conducive to the removing of active oxygen, the generation of delayed motion fatigue and athletic injury simultaneously.Luo Qiong etc. by the lycium barbarum polysaccharide of purification (LBP-X) by 5,10,20,50 and 100mg/ (kgd) fills with respectively hello mice, carry out anti-fatigue test, this research finds that 1. LBP.X can significantly increase Mouse Muscle glycogen, hepatic glycogen storage level, by increasing the energy matter deposit, for providing multipotency more, body reaches the purpose of resisting fatigue; 2. LBP can improve the forward and backward blood lactic acid dehydrogenase total activity of motion, and the lactic acid of piling up in muscle due to motion is transformed into to acetone acid, by removing the metabolite of body after strenuous exercise, carrys out delay fatigue; 3. LBP can reduce the recruitment of blood urea nitrogen after mice strenuous exercise, accelerates its clearance rate; 4. all, with LBP.X ms/ (kgd) dosage group best results, this test has disclosed the dose,optimum of its existence to above 3 kinds of effects, and dose is larger, and effect is better.
Radix Puerariae
The dried root that Radix Puerariae is legume pueraria lobata or Radix Puerariae rattan, the Radix Puerariae rattan is practised again and is called Pachyrhizua angulatus.Be stated from<Sheng Nong's herbal classic of Radix Puerariae beginning>, classify middle product as, the successive dynasties book on Chinese herbal medicine is all on the books.Put down in writing its sweet in the mouth, flat, micro-cool.Enter spleen, stomach warp.The effects such as expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal are arranged.In recent years, going deep into along with Chinese crude drug research.The clinical scope of Radix Puerariae has had further expansion. and clinical practice and Utilization Prospect are expected already. now its pharmacology and clinical application research overview be summarized as follows.Diabetics, along with the prolongation of the course of disease, blood viscosity increases, Impairment of Red Cell Deformability, slow blood flow.The experiment of Jing Yuan etc. shows, the blood viscosity of STZ rat, all indexs of packed cell volume all have rising, shows mankind's feature that hemorheology sexually revises while suffering from diabetes.Radix Puerariae extract can obviously reduce high viscosity, low viscosity and plasma viscosity, the packed cell volume cut cut of STZ rat whole blood.Because height is cut blood viscosity and is mainly reflected erythrocyte deformability, low cut blood viscosity and mainly reflect erythrocytic ability of aggregation, show that Radix Puerariae extract has the pharmacological action that reduces blood viscosity, improves local blood circulation, can be used for prevention and treatment diabetes and chronic complicating diseases, the quality of life of improving diabetics.Pueraria lobata is oral to rabbit, starts 2 hours blood glucoses risings and descends immediately, within the 3rd, 4 hours, descends minimum.To the rabbit adrenal gland without hesitation hyperglycemia not only without the antagonism effect, make it on the contrary to increase, but can promote blood glucose to recover ahead of time normal.Radix Puerariae rope (500rag) has remarkable blood sugar reducing function to four oxygen pyridine hyperglycemia mouse gavagings, and 250mg approaches its inefficient amount.But the compound recipe that 250mg/kg/d puerarin 50IIlg/kg/d aspirin forms falls obviously, and can maintain more than 24 hours. also can obviously improve the carbohydrate tolerance of alloxan mice, obviously to adrenolytic, rise the effect of blood eaves.
1, the impact of Radix Puerariae flavone on diabetic mice body weight, amount of drinking water and blood glucose
Experimental result shows, the body weight of diabetic groups mice obviously descends, average amount of drinking water and blood glucose value all obviously increase, with normal group comparing difference highly significant (P<0.001). this diabetic mice model " three-many-one-little " phenomenon is obvious, and the modeling success is described. and relatively, body weight is all gone up to some extent for Radix Puerariae flavone group and diabetic groups, amount of drinking water obviously reduces, blood glucose descends to some extent, illustrates that Radix Puerariae flavone has certain hypoglycemic activity, the state of an illness of energy diabetes-alleviating mice. in Table 7.
The impact (n=10) of each group of table 7 experiment on Mouse Weight, amount of drinking water and blood glucose
Figure GSB0000113276770000181
Annotate: * P<0.001 υ s normal group; * P<0.01, P<0.01 υ s diabetic groups
2, the impact of Radix Puerariae flavone on glucose tolerance in mice
Experiment finishes the previous day and detects the glucose tolerance in mice situation of respectively organizing, experimental result shows: the normal group glucose tolerance in mice is normal, and the carbohydrate tolerance of diabetic groups mice is obviously undesired, and the carbohydrate tolerance of Radix Puerariae flavone group has than diabetic groups and obviously take a favorable turn, significant difference (P<O.01), in Table 8.
The impact (n=10) of each group of table 8 experiment on glucose tolerance in mice
Annotate: * P<0.001 υ s normal group; , P<0.01 υ s diabetic groups
3, the impact of Radix Puerariae flavone on mice fructosamine and AGEs
The fructosamine of diabetic groups mice serum, AGEs level are compared obvious rising with normal group, and difference highly significant (P<0.001), and the Radix Puerariae flavone group can make mice serum fructosamine and AGEs content obviously descend, with diabetic groups mice comparing difference remarkable (P<0.01), in Table 9.
The impact (n=10) of each group of table 9 experiment on mice fructosamine and AGEs
Figure GSB0000113276770000191
Annotate: * P<0.001 υ s normal group; P<0.01 υ s diabetic groups
4, the impact of Radix Puerariae flavone on sorbitol, sorbito dehy drogenase and aldose reductase in mice serum
Due to sorbitol, sorbito dehy drogenase, aldose reductase is the important enzyme system of polyhydric alcohol path, aldose reductase catalysis glucose changes sorbitol into, and the effect of sorbito dehy drogenase is that sorbitol is converted into to fructose, therefore sorbitol and aldose reductase content raise, while sorbito dehy drogenase content reduces the very close relationship that has with diabetic complication. and experimental result shows: the sorbitol of diabetic groups and aldose reductase content all significantly raise, the content of sorbito dehy drogenase obviously reduces, with normal group, there were significant differences (P<O.01), two kinds of medicine groups obviously take a favorable turn than the diabetic groups comparable situation. and illustrate that Radix Puerariae flavone can cause the content generation significant change of polyhydric alcohol path (PP) approach relevant enzyme, certain preventive and therapeutic effect to having of diabetic complication, in Table 10..
The impact (n=10) of each group of table 10 experiment on sorbitol, sorbito dehy drogenase and aldose reductase in mice serum
Annotate: * P<0.001, P<0.001 υ s normal group; P<0.01 υ s diabetic groups
5, the impact of Radix Puerariae flavone on AGEs in the Organs of Mice tissue
Increase along with diabetic duration, can can affect the normal physiological function of each internal organs by increasing of a certain amount of AGEs.AGEs of accumulation in each organs and tissues of diabetic mice, causing the generation of chronic complicating diseases. experimental result shows: the content compared with normal group showed increased of AGEs in the diabetic groups Organs of Mice, than diabetic groups, all decreasing in varying degrees, in Table 11.
The impact (=10) of each group of table 11 experiment on AGEs in the Organs of Mice tissue
Figure GSB0000113276770000201
Annotate: * P<0.05, * * P<0.01 normal group; P<0.01 υ s diabetic groups
6, the impact of Radix Puerariae flavone on sorbitol content in the mice organs tissue
In each internal organs of diabetic mice, the increase of sorbitol content is also closely related with the generation of diabetic complication. and experiment shows that each internal organs sorbitol content compared with normal group of diabetic groups obviously increases, and there were significant differences (P<0.05), than diabetic groups, the sorbitol content at each internal organs all decreases in varying degrees, experimental result shows that Radix Puerariae flavone group effect is more obvious, the effect that Radix Puerariae flavone has obvious prevent diabetes complication to occur is described, in Table 12.
The impact (n=10) of table 12 Radix Puerariae flavone on sorbitol content in the mice organs tissue
Figure GSB0000113276770000202
Annotate: * P<0.05 normal group; * P<0.01 υ s diabetic groups
Sorbitol, mannitol, sucralose, magnesium stearate, microcrystalline Cellulose:
Consider Caulis et Folium Brassicae capitatae, Fructus Momordicae charantiae extract, Rhizoma Polygonati, Folium Mori, Fructus Lycii, higher and the taste medicine of the sugary and vitamin of Radix Puerariae does not meet the characteristics of modern's custom, and the operability of the course of processing we selected the food additive Sorbitol, mannitol, sucralose, magnesium stearate, microcrystalline Cellulose, according to the Zhu Yu of Guangzhou Inst of Chemistry, Chinese Academy of Sciences qin, Tang Liegui, in " one one kinds of multi-functional macromolecular materials of microcrystalline Cellulose " literary composition that Pan Songhan delivers on the 3rd phase at " Chemical Industry in Guangzhou " the 21st volume in 1993, show: microcrystalline Cellulose can be used as antiplastering aid.The microcrystalline Cellulose addition, for 15% of formula, meets GB2760 " food additive use sanitary standard ", and microcrystalline Cellulose toxicity ADI does not do particular provisions (FAO/WHO, 1994); Sorbitol, mannitol, sucralose, magnesium stearate, as sweetener, are corrected mouthfeel, and addition meets GB2760 " food additive use sanitary standard " makes its whole formula have more reasonability and science like this.
Pharmacology and drug effect according to above-mentioned various raw materials, consider, a kind of medicine is provided, and its recipe ratio is: Caulis et Folium Brassicae capitatae 4.5-15g, Fructus Momordicae charantiae extract 3-9g, Rhizoma Polygonati 4.5-12g, Folium Mori extract 4.5-12g, Fructus Lycii 3-5g, Radix Puerariae 4.5-12g, microcrystalline Cellulose 3-10g, xylitol 3-10g, mannitol 3-5g, sucralose 0.4-1g.
Preferred implementation is that recipe ratio is: Caulis et Folium Brassicae capitatae 4.5g, Fructus Momordicae charantiae extract 3g, Rhizoma Polygonati 4.5g, Folium Mori extract 4.5g, Fructus Lycii 3g, Radix Puerariae 4.5g, microcrystalline Cellulose 3g, xylitol 3g, mannitol 3g, sucralose 0.4g;
Another preferably embodiment be that recipe ratio is: Caulis et Folium Brassicae capitatae 15g, Fructus Momordicae charantiae extract 9g, Rhizoma Polygonati 12g, Folium Mori extract 12g, Fructus Lycii 5g, Radix Puerariae 12g, microcrystalline Cellulose 10g, xylitol 10g, mannitol 5g, sucralose 1g;
Best a kind of embodiment is: Caulis et Folium Brassicae capitatae 11g, Fructus Momordicae charantiae extract 7g, Rhizoma Polygonati 9g, Folium Mori extract 8g, Fructus Lycii 4.1g, Radix Puerariae 7.8g, microcrystalline Cellulose 8.5g, xylitol 8.5g, mannitol 4.2g, sucralose 0.68g;
The effective ingredient of medicine distributes as follows: the 100g medicine is containing the sweet 375mg of effective composition sulfur, polysaccharide 15g, total saponins 5g, flavone 6g.
In addition, a kind of method that configures said medicine also is provided, first Rhizoma Polygonati, Fructus Lycii, Radix Puerariae medicine are pulverized respectively, cross the 80-100 sieve, get respectively the weighing by a certain percentage of its powder and Caulis et Folium Brassicae capitatae, Fructus Momordicae charantiae extract, Folium Mori extract, microcrystalline Cellulose, xylitol, mannitol, sucralose, mixed again, mix 45 minutes (guaranteeing mix homogeneously), then carry out tabletting (sheet is heavily controlled by inner quality standard), screened again, polishing, carry out again inner packing, then carry out outer package, finally the check warehouse-in; Within whole course of processing environment is controlled 25 ℃ of left and right of temperature, humidity 35%.
The present invention has following beneficial effect: immunity, the assisting in reducing blood sugar symptom that can strengthen the people, improve people's health level, have no side effect and untoward reaction, and use modern preparation technique, advanced method of quality control, make product accomplish safety, stable, quality controllable.
More than this specific embodiment, several raw materials are mutually auxiliary in whole formula deposits mutually, bring out the best in each other, make full side present effect preferably, meet the composite reason of Chinese medicine, product has obvious enhancing immunity and obvious function of blood sugar reduction through function test proof this product.
More than this specific embodiment, several raw materials are mutually auxiliary in whole formula deposits mutually, brings out the best in each other, and makes full side present effect preferably, and product has obvious enhancing immunity and auxiliary hyperglycemic effect through function test proof this product.

Claims (1)

1. the health medicine of an enhancing immunity, function of blood sugar reduction, it is characterized in that, it consists of following component: Caulis et Folium Brassicae capitatae 11g, Fructus Momordicae charantiae extract 7g, Rhizoma Polygonati 9g, Folium Mori extract 8g, Fructus Lycii 4.1g, Radix Puerariae 7.8g, microcrystalline Cellulose 8.5g, xylitol 8.5g, mannitol 4.2g, sucralose 0.68g, its effective ingredient distributes as follows: the 100g medicine is containing the sweet 375mg of effective composition sulfur, polysaccharide 15g, total saponins 5g, flavone 6g.
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