CN101253903B - Health food with fat-reducing function and its preparation - Google Patents

Health food with fat-reducing function and its preparation Download PDF

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CN101253903B
CN101253903B CN2008101035074A CN200810103507A CN101253903B CN 101253903 B CN101253903 B CN 101253903B CN 2008101035074 A CN2008101035074 A CN 2008101035074A CN 200810103507 A CN200810103507 A CN 200810103507A CN 101253903 B CN101253903 B CN 101253903B
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extract
health food
dry extract
fat
weight
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CN101253903A (en
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王利明
隋丽梅
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BEIJING HUIZHONG MINGJIE BIOLOGICAL TECHNOLOGY Co Ltd
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BEIJING HUIZHONG MINGJIE BIOLOGICAL TECHNOLOGY Co Ltd
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Abstract

The invention relates to healthy food with weight-losing function as well as the preparation method thereof, which belongs to the healthy food field. The healthy food with weight-losing function comprises active ingredients which are prepared from the following bulk drugs by the weight proportion as follows: gen-seng 1-6, acanthopanax sessiflorus tea 1-8, oolong tea 1-5, notoginseng 1-5, tuckahoe 1-5, and alisma orientale 1-3. Experiments on animals and human bodies show that the inventive healthy food has remarkable weight-losing function and is applicable to people with adiposis caused by various reasons except children.

Description

A kind of health food and preparation method thereof with weight losing function
Technical field
The present invention relates to a kind of health food and preparation method thereof, belong to field of health care food with weight losing function.
Background technology
Obesity is a kind of common chronic disease, and especially in some economically developed countries, the obesity patient increases severely.France's " science and life " periodical reported once that present global obesity patient surpasses 300,000,000, and still is being on the increase, and was the most serious with the America and Europe especially.In developing country, along with the improvement gradually of eating condition, the obesity patient is also increasing gradually.In nearest 10 years world's obesity incidence of disease ranking list statistical graphs that the pharmacology professor GerethWillams of Britain Liverpool An Shu hospital announces, China is listed in the 10th impressively.The nutrition survey report of China shows that also over 20 years, 4 overweight rates of adults in areas group such as Beijing, Shanghai have surpassed 30%.There is very big regional disparity in overweight and obesity rates in China, and the north is higher than south; The developed area surpasses backward areas; The women surpasses the male sex.In addition, children's the simple obesity incidence of disease is also improving constantly, and according to investigations, Beijing child's obesity incidence has had growth at double than the report before 10 years.One studies show that, still suffers from obesity after 40% 7 years old Obese children and 70% puberty, fat teenager grew up.Therefore, children obesity must be treated as early as possible.
Obesity can cause metabolism and endocrine disturbance, and can increase the initiation potential of diseases such as type ii diabetes, atherosclerotic, high fat of blood, hypertension, coronary heart disease.Thereby obesity has become current comparatively general Social Medicine problem.
Up to now, the method for comparatively common prevention and treatment of obesity has four kinds of medicinal treatment, dietetic treatment, kinesiatrics and behavior therapies.Medicine with fat-reducing effect is mainly the appetite inhibitor, quickens the hormone of metabolism, influence is digested and assimilated with the medicine of lipid mobilization etc.Appetite inhibitor is to regulate by the effect of catecholamine and serotonin mediator to ingest and the diet maincenter mostly, reduces appetite, thereby body weight is descended.This class medicine mainly contains amphetamine and derivative Fenfluramine thereof etc.The hormone and the medicine that quicken metabolism mostly rise metabolic rate by increasing living heat, thereby reach the fat-reducing purpose.They mainly contain thyroid hormone, growth hormone and intend beta-adrenergic medicine etc.If the drug main that influence is digested and assimilated increases satiety by prolonging the emptying time of stomach, the factors such as energy and nutraceutical absorption that reduce descend body weight.These medicines comprise dietary fibre, SPE etc.And mobilize fat-splitting medicine is by stimulating beta receptor or suppressing a 2Acceptor impels the fat oxidation heat production to reach the fat-reducing purpose.As norepinephrine, Yohimbine etc.
Though these medicines all have antiobesity action, certain side effect is arranged mostly, cause nausea easily, bad reaction such as abdominal distension, diarrhoea and functional lesion, after drug withdrawal, also be easy to cause bounce-back.And drug therapy the time, generally still needing cooperates low caloric diet to increase fat-reducing effect.In fact, be not only medicinal treatment, even kinesiatrics and behavior therapy also need in conjunction with hyposite.This shows that dietetic treatment is the most basic, safest method of weight-reducing.Therefore the food that screens the pure natural with antiobesity action has become an important topic in the research process of losing weight.People exist a large amount of demands to better effects if, that have no side effect and have the health food of weight losing function.
Summary of the invention
The present invention is directed to the defective in the above-mentioned field, a kind of more efficiently, health food with weight losing function is provided, it is formed all is medicines that can be used for health food production of ratifying through the Ministry of Public Health, state food and Drug Administration, the theory standard that meets integration of drinking and medicinal herbs fully is a kind of green health care food.
Another object of the present invention has provided the preparation method of this health food.
A kind of health food with weight losing function, its active component is mainly made by following bulk drugs: American Ginseng 1-6 part, Sessileflower Acanthopanax Bark tea 1-8 part, oolong tea 1-5 part, pseudo-ginseng 1-5 part, Poria cocos 1-5 part, rhizoma alismatis 1-3 part.
Preferably: 1 part of American Ginseng, 2 parts of Sessileflower Acanthopanax Bark tea, 2 parts in oolong tea, 1 part of pseudo-ginseng, 1 part in Poria cocos, 1 part of rhizoma alismatis.
Also contain garlic 1-3 part, matrimony vine 1-3 part, lotus leaf 1-6 part, hawthorn 1-8 part, chrysanthemum 1-6 part in the wherein said bulk drug.
Preferably: 1 part in garlic, 1 part of matrimony vine, 3 parts on lotus leaf, 2 parts of hawthorn, 1 part of chrysanthemum.
Wherein also contain hydroxycitric acid 0.1-0.5 part, konjaku powder 0.1-0.7 part, l-cn 0.1-0.3 part in the active component.
Preferably: 0.2 part of hydroxycitric acid, 0.3 part of konjaku powder, 0.1 part of l-cn.
The formulation of described health food is a soft capsule.
Its preparation method:
1) take by weighing American Ginseng, pseudo-ginseng 2 flavor bulk drugs in proportion, with 60% alcohol extract twice, it is concentrated as to catch up with not dry extract 1 to merge the extract vacuum;
2) take by weighing Poria cocos, rhizoma alismatis 2 flavor bulk drugs in proportion, with 70% alcohol extract twice, it is concentrated as to catch up with not dry extract 2 to merge the extract vacuum;
3) take by weighing Sessileflower Acanthopanax Bark tea, oolong tea in proportion and extract 1 time with aquae destillata, with the extract vacuum concentrate dry extract 3;
4) take by weighing garlic, matrimony vine, lotus leaf, hawthorn, chrysanthemum in proportion, extract 1 time with aquae destillata, with the extract vacuum concentrate dry extract 4;
5) merge dry extract 1, dry extract 2, dry extract 3 and dry extract 4, it be ground into 200 order powder, take by weighing hydroxycitric acid, konjaku powder, l-cn blending in proportion after, make soft capsule according to a conventional method.
The dry extract that obtains after described the concentrating also need is following dry 3 hours at 50-60 ℃.
Health food with weight losing function disclosed by the invention, it mainly is to be prepared from according to a certain weight ratio by American Ginseng, Sessileflower Acanthopanax Bark tea, oolong tea, matrimony vine, pseudo-ginseng, lotus leaf, Poria cocos, rhizoma alismatis, hawthorn, chrysanthemum, garlic, hydroxycitric acid, konjaku powder, l-cn etc.
Above-mentioned several raw material is made the health food of all kinds of formulations through the active component that ethanol or extraction with aqueous solution obtain.
American Ginseng is the root of Araliaceae American Ginseng Panax quinquefolium L..Also name American ginseng (" property of medicine is examined "), American ginseng (" middle traditional Chinese medicines are planted will ") etc.Found during American Ginseng is wanted 17 kinds of ginsenosides (ginseno)-R0 ,-Rb1 ,-Rb2 ,-Rb3 ,-Rc ,-Rd ,-Re ,-Rf ,-Rg1 ,-Rg2 ,-Rg3 ,-Rh1 ,-Ra0, quinquenosiid R1, gypenoside X1, F3, F11.By proving with experiment in vitro in the body, total saponin(e of stem and leaves of American ginseng and ginsenoside Re, Rb1, Rb can suppress the pancreatic lipase activity, and the anti-obesic action of the total saponin(e of stem and leaves of American ginseng may be because the Ginsenoside Rc, Rb1, Rb in the American ginseng total saponins suppresses the assimilate food result of fat of small intestine.
Sessileflower Acanthopanax Bark tea is the tea that Araliaceae machaka Sessileflower Acanthopanax Bark leaf is made, and Sessileflower Acanthopanax Bark and wilsonii are equal to be belonged to together.Thorn on Sessileflower Acanthopanax Bark stem, the branch seldom is bordering on stinglessly, is distributed in each mountain area on the south the Xiaoxinanlin Mountains, Heilongjiang Province.The Sessileflower Acanthopanax Bark branches and leaves are luxuriant, and flowers and fruits are unusual, except that being a kind of viewing and admiring the tree, still are a kind of wild vegetable and important medicinal plant of keeping healthy.The tea that the Sessileflower Acanthopanax Bark leaf is made contains micro-alkaloid, cardiac stimulant worker glucoside and 0.2% volatile oil and nicotinic acid, contains 0.23% cardiac glycoside, 0.1% volatile oil and a small amount of saponin.The pharmacological action of Sessileflower Acanthopanax Bark tea is multifarious, has strengthening by means of tonics, adjusts effects such as blood pressure, nerve, blood sugar and cholesterol.
Oolong tea is described as " tea of weight reducing " seventies and enters Japan, and spreads in the young woman who pays close attention to fat-reducing very soon, and the research of health efficacy begins to launch.In these more than 30 years,, various effects have been disclosed through numerous researcher's researchs.Include: anti-fat, suppress increased blood pressure, improve medium-sized fat, reduce cholesterol value, suppress that blood sugar rises, anticancer, skin makeup, beauty treatment, improve allergic reaction, various effects such as the rhythm of making the life better, prevention decayed tooth.Fujian Institute of Traditional Chinese Medicine has carried out following experiment: with simple obesity person is the object of observation, drinks continuously after the oolong tea, carries out clinical observation at the effect that suppresses obesity and the regulatory function of phat fat metabolism.Experimental session stops all regimen that has fat-reducing effect and kinesiatrics, requires their normal diet in the time in 6 weeks.Experimental result: simple obesity patient 75 examples, body weight descends, and what remarkable result occurs accounts for 15%, and what effective effect occurs accounts for 52%, and total effective rate reaches 67%.Oolong tea has aliphatic acid effect of combustion in the blood of promotion, the function in the intensive aspect, the consumption that improves heat.
Matrimony vine is the fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Contain carrotene 3.39% in the matrimony vine, thiamines is mutual 0.23%, and nuclear is yellow mutual 0.33%, Yan acid 1.7%, ascorbic acid 3%.The fruit water-soluble portion contains LBP-X, and about 6%~8%.Studies have shown that the normal mouse of the Acc mRNA content in the injury of hypothalamus obesity mice adipose tissue obviously reduces, and after taking in LBP-X-4, the Acc mRNA level in its adipose tissue significantly improves.Therefore, its functions of lowering blood-fat and reducing weight may be realized by the metabolism of control agent self-energy.
Pseudo-ginseng is the dry root of Araliaceae Panax notoginseng (Burk.) F.H.Chen.Ground such as main product Yunnan mountain of papers, Yanshan County, Guangnan, Maguan and Jingxi, Guangxi, peaceful limit, Baise.Sweet, little hardship, temperature.Gui Jing, stomach warp.The block up that looses stops blooding detumescence ding-tong.Be used for spitting of blood, spit blood, bleeding from five sense organs or subcutaneous tissue is had blood in stool, uterine bleeding, traumatism and bleeding, chest ventral spine pain, tumbling and swelling.Experimental study shows that the Radix Notoginseng powder preparation can stop rabbit intestinal absorption fat.In lipid-metabolism, can reduce TL level and TG content, in feed, sneak into 2% Radix Notoginseng powder, raising rabbit is after 6 weeks, and serum TC and TG content significantly reduce.The histotomy microscopy finds that the fat deposit of Radix Notoginseng powder group arteries significantly alleviates.
Lotus leaf, lotus leaf are the dried leaves of Nymphaeceae platymiscium lotus Nelumbo nucifera Gaertn..Traditional medicine is thought lotus leaf nature and flavor bitter cold, has clearing summer-heat and damply, and hair tonic is sun clearly, and the activity of hemostasis Li Shui of reducing phlegm and internal heat clearing away heart-fire.According to Compendium of Material Medica record " lotus leaf is obeyed it, makes us thin bad ", " hair tonic vigour, benefit helps taste, puckery essence is turbid, the extravasated blood that looses, the detumescence pain is sent out variola ".Auxiliary antilipemic and weight losing function are that block mold is observed the influence of lotus leaf water extract to serum total cholesterol (TC) and triglycerides (TG) with the acute hyperlipemia mouse, and treated in vitro is observed medicine has inhibition trend to the liver cell synthetic cholesterol.With the lotus leaf alcohol extract hyperlipemia in mice is carried out pharmacological evaluation, the result proves that the lotus leaf alcohol extract can obviously reduce mouse TC content, with positive controls (yodonicit sheet) there was no significant difference.With the lotus leaf biology total alkali is index, investigates the influence of such material to fat hyperlipidemia rats blood fat and body weight.The result shows, lotus leaf biology total alkali 2.14~10.7mg/kg all can reduce TC, TG and the body weight gain index such as the Lee ' s index of obese rat, relatively there were significant differences (P<0.05 or P<0.01) and have dose dependent with model group, but not obvious to HDL (HDL-C) effect.Experimental results show that the lotus leaf electuary can reduce TC, the TG content in the tentative hyperlipidemia of rabbit, all has inhibitory action to lipid precipitation in the animal tissue and atherosclerotic.By intervention test to the high fat of blood animal model, confirm that lotus leaf can slow down the increase of obese rat body weight, promote the adipocyte metabolism, reduce adipocyte synthetic glycerine three esters and suck aliphatic acid, enzyme hydrolysis and the free fatty of strengthening triglycerides discharge in blood, and certain functions of lowering blood-fat and reducing weight is arranged.
Poria cocos is the dry sclerotia of Polyporaceae plant Poria cocos Poria cocos (Schw.) Wolf.It is sweet, light to distinguish the flavor of, and property is flat.The thoughts of returning home, spleen, lung channel.Function: eliminating dampness and diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Cure mainly: difficult urination, oedema turgor, phlegm and retained fluid are coughed contrary, n and V, are had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.
Rhizoma alismatis is the stem tuber of Alismataceae plant rhizoma alismatis Alisma orientale (Sam.) Juzep..Cold in nature, it is sweet to distinguish the flavor of.Diuresis, heat-clearing.Be used for difficult urination, oedema turgor, the oliguria of having loose bowels, phlegmatic vertigo, the puckery pain of heat pouring, hyperlipemia.Rhizoma alismatis can obviously reduce cholesterol in serum, triglycerides and LDL-C, promotes the Serum HDL-C level to raise, the generation of obviously resisting the aortic tunica intima patch, and administration in advance then shows prevention effect.
Hawthorn is the fruit of rosaceous plant hawthorn Crataegus pinnatifida Bge. or fructus crataegi cuneatae.Also haw (" 101 choosing side ") in the famous mountain.Flavor acid, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.Function: long-pending, diffusing extravasated blood, expelling tenia help digestion.
Chrysanthemum, this product are the dry capitulum of feverfew.Contain chrysanthemum glycosides, chloro acid, flavonoids and mcg vitamin B1 in spending.Pharmacological action, this product coronary artery dilating increases coronary flow, brings high blood pressure down, and resists local capillary permeability.Analgesic in addition, antibacterial in addition etc.Modern times are useful on treatment hypertension, artery sclerosis, coronary heart disease etc.
Garlic is in China, Greece, Rome, the Egyptian all useful garlic history as health food.The bactericidal action of garlic is well-known, and the allicin in the garlic has the antibiotic effect.Therefore trithio pi-allyl in the garlic has vasodilative effect, can resist hematoblastic cohesion, can reduce peripheral resistance and brings high blood pressure down and prevent thrombosis.Garlic also has norcholesterol, aid digestion and resist effect such as tumour.Respectively with the dosage of 0.4g (kg body weight d) and 1.2g (kg body weight d) the fat rat model 30d that feeds, two dosage groups are compared with model control group with garlic runic thing, and body weight, physique heavily reach body fat and descends than conspicuousness is all arranged, and existence and dosage correlation.The antiobesity action of garlic may be because the sulfide compound that the multiple pi-allyl in the crude extract, propyl group and methyl are formed.These sulfide compounds are by increasing BAT and promoting adrenal medella secretion adrenaline, norepinephrine to improve the body heat production.
Hydroxycitric acid, the HCA full name is: hydroxycitric acid; Chinese name is " hydroxycitric acid ".It is the natural extract of a kind of " HCA " by name.The action principle of HCA exactly when human glucose transfers fat to, suppresses the ferment of one of them ATP Citrate lyase, and aliphatic acid can't be synthesized, and suppresses the carrying out that sugar is separated (glycolysis) effect.HCA chemical constitution: HO-CH 2-(CH 2) 6-CH=CH-COOH (C 10H 18O 3).In food entered our body, carbohydrate promptly was decomposed into little molecule glucose, and entering blood becomes blood sugar, and then to deliver to each cell of whole body be energy with the metabolism.If glucose is not utilized immediately, just be stored in muscle and form glycogen (Glycogen), if but that glycogen has stored is full, glucose promptly is converted to citric acid through the sugar effect of separating with citrate cycle, synthesizes fat through ferment ATP-Citrate lyase catalysis again.The contained HCA of HCA extract is the citric acid analog, can compete the activity that suppresses ferment ATP-Citrate lyase, so unnecessary carbohydrate is converted to fatty process in the baffle, finds after deliberation, in 8-12 hour after meal, the aliphatic acid that HCA can reduce 40-70% synthesizes.HCA comes from the pure natural extract, clear and definite chemical composition of Western medicine raw material and fat-reducing mechanism are arranged again simultaneously, it is by suppressing the synthetic of fat, promote the burning of aliphatic acid, reduce the absorption of food, the Trinity reaches the effect of weight reducing fat-reducing, be a kind of rare, present desirable, the most healthy Weight-reducing health raw material of fat-reducing effect.HCA prevents that body weight from increasing (bounce-back) better effects if to helping behind the weight-reducing.Not at all easy body weight is subtracted the people that gets off for those, added the product of HCA raw material, body weight that can more effective maintenance oneself by picked-up.HCA is particularly suitable for the Asians: it should be noted that especially because citrate lyase (citrate lyase) only works under the situation that carbohydrate is excessively taken in, so to be particularly suitable for starch be the Asians of staple food.In other words Chinese to use HCA to be used for the weight-reducing effect better than the occidentals.HCA is a kind of natural extract, does not still have report at present and shows its toxic or side effect.
Its main component of konjaku powder is mannosan, protein, pectin and starch.It is a kind of high fiber, low fat, natural diet food low in calories.Contain the mannosan about 60% in the konjaku, water imbibition is very strong, and suction back volumetric expansion can be filled stomach and intestine, eliminates hunger.Konjaku can delay digesting and assimilating of nutrient, reduces the absorption to monose, makes aliphatic acid synthetic decline in vivo, thus the growth of control body weight, so can reach the purpose of fat-reducing.
L-cn (L-carnitine) is once called as DL-carnitine chloride, is to be found first in meat extract by Russianize scholar Gulewitsch and Krimberg in 1905.The molecular formula C of L-carnitine 7H 15NO 3, relative molecular mass 161.20.It is a kind of white water imbibition crystallization, and very easily water-soluble (250g/100g) and ethanol are insoluble to ether, acetone, benzene, 210~212 ℃ of fusing points.Because the L-carnitine can satisfy physiological requirements by synthesizing by people and multiple animal in health, so the vitamin that it neither be truly, be the vitamin-like material of a kind of class.It has a lot of important physiological function.
Modern Chinese medicine is thought, obesity cause of disease complexity, and each disease type haves both at the same time clinically, treatment and the suitable giving consideration to both the incidental and fundamental of health care, the same usefulness of reinforcing and reducing methods, the number method is also executed, and can obtain reasonable effect.
Modern Chinese medicine thinks that the disease somatotype of distinguishing of obesity can be divided into five kinds: 1. insufficiency of the spleen damp-obstruction type clinical manifestation be body obesity, limbs be stranded weight, lassitude hypodynamia, abdominal fullness and distention, receive the difference food less, big loose stool is thin, tongue nature is light, greasy and thin fur, arteries and veins is slow or moisten carefully.Much more this kind of see clinically.The health care principle is invigorating the spleen for eliminating dampness.2. the spleen kidney both deficiency type clinical manifestation be body obesity, impractical swelling, fatigue and weak, deficiency of QI with disinclination to talk, movingly pant, dizzy chilly, that food is received less is poor, waist knee crymodynia, big loose stool is thin or have loose bowels just before dawn, impotence, tongue nature is light, tongue is thin in vain, deep thready pulse.Severe obesity patient mostly is this kind of.The health care principle is warm yang transforming qi Li Shui.3. the clinical manifestation of stomach energy damp-obstruction type be the body obesity, like that food delicious food or rapid digestion of food and polyorexia, halitosis dry, constipation, tongue nature are red, yellowish fur, slippery and rapid pulse.This kind of mostly is the strong young and middle-aged overweight people of body.The health care principle is the logical internal organs of clearing away heat and eliminating dampeness.4. the qi stagnation and blood stasis type clinical manifestation be that body obesity, two side of body turgors, gastral cavilty ruffians are full, irritated irritability, mouth parched and tongue scorched, have a dizzy spell, insomnia and dreamful sleep, irregular menstruation or amenorrhoea, dark tongue quality have ecchymosis, wiry and frequent pulse or thin string.Obesity with the passing of time the person visible this kind of.The health care principle is a liver-smoothing, qi-regulating, promoting blood circulation and removing blood stasis.5. the clinical manifestation of kidney-yin deficiency type is body obesity, dizzy headache, dysphoria in chestpalms-soles, soreness and weakness of waist and knees, the red few tongue of tongue, thready rapid pulse or thin string.This kind of is relatively more rare clinically.The health care principle is enriching yin and nourishing kidney.
We are monarch drug in a prescription with American Ginseng, Sessileflower Acanthopanax Bark tea, oolong tea, matrimony vine, pseudo-ginseng, benefit lung yin, the clear fire of deficiency type, replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain, nourishing liver and kidney, benefiting shrewd head, anti-simultaneously obesity, prevention fat absorption, reduction TL level and TG content reach effect of weight reducing; With lotus leaf, Poria cocos, rhizoma alismatis, hawthorn, chrysanthemum, garlic is ministerial drug, and beneficial spleen and stomach, eliminating dampness and diuresis, long-pending, the extravasated blood that looses that helps digestion are aid digestion simultaneously, bring high blood pressure down; Help again with hydroxycitric acid, konjaku powder, l-cn, the raw material that adds this three flavors natural additive for foodstuff makes material as the assistant of this prescription, can play minimizing and delay digesting and assimilating of nutrient, reduction is to the absorption of monose, make aliphatic acid synthetic decline in vivo, thereby the growth of control body weight, thus can reach the purpose of fat-reducing, also make simultaneously this prescription fat-reducing effect better more comprehensively.
The used medicine of the present invention all adopts the ethanol or the aqueous solution to extract, the temperature that refluxes is lower than 100 ℃, make active ingredient in the medicine be difficult for Yin Gaowen and change, when concentrated, adopt vacuum to concentrate simultaneously, make the active ingredient in the extract not be subjected to temperatures involved, avoided some destruction and loss, preserved the nutritional labeling and the fragrance of raw material better heat-labile active ingredient.The dry extract that obtains after concentrating need 50-60 ℃ dry 3 hours down, could finish-drying.
Experiment shows that health products of the present invention have tangible weight losing function through animal and human's body, can also strengthen immunity simultaneously, need to be used to slimmer and immunocompromised person, also is applicable to children.
The prepared dry extract active component of the present invention can add various conventional auxiliary material required when preparing different dosage form, as disintegrant, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as pill, powder, tablet, capsule, oral liquid etc., the present invention adopts soft capsule dosage form, dry extract and edible corn ready-mixed oil are mixed at 1: 1.2, and add the beeswax of dry extract weight 2%, the soft capsule of packing into.Each soft capsule contains active component 0.72g.The rhythm of life of considering the modern is than very fast, and the present invention adopts soft capsule preparation, and is easy to carry, absorb rapidly.
The specific embodiment
Further set forth health food of the present invention with experimental example by the following examples.
Embodiment 1
Feed proportioning: American Ginseng 1000g, Sessileflower Acanthopanax Bark tea 2000g, oolong tea 2000g, garlic 1000g, matrimony vine 1000g, pseudo-ginseng 1000g, lotus leaf 3000g, Poria cocos 1000g, rhizoma alismatis 1000g, hawthorn 2000g, chrysanthemum 1000g, hydroxycitric acid 200g, konjaku powder 300g, l-cn 100g.
Its preparation method:
1) take by weighing American Ginseng, pseudo-ginseng 2 flavor bulk drugs in proportion, extract and use 60% alcohol extract, refluxed 3 hours, extract twice, merging extract vacuum is concentrated as to catch up with not dry extract 1;
2) take by weighing Poria cocos, rhizoma alismatis 2 flavor bulk drugs in proportion, extract and use 70% alcohol extract, refluxed 3 hours, extract twice, merging extract vacuum is concentrated as to catch up with not dry extract 2;
3) take by weighing Sessileflower Acanthopanax Bark tea in proportion, oolong tea extracts with distilled water, refluxed 2 hours, with the extract vacuum concentrate dry extract 3;
4) take by weighing garlic, matrimony vine, lotus leaf, hawthorn, chrysanthemum in proportion, extract, refluxed 2 hours with distilled water, with the extract vacuum concentrated dry extract 4;
5) merge dry extract 1, dry extract 2, dry extract 3 and dry extract 4, it is ground into 200 order powder, take by weighing hydroxycitric acid, konjaku powder, l-cn more in proportion, after the 1700g blending, be filled into capsule shells altogether by the soft capsule method for production.It is 0.72g that every soft capsule contains active component.
Embodiment 2
Feed proportioning: American Ginseng 2000g, Sessileflower Acanthopanax Bark tea 8000g, oolong tea 1000g, garlic 3000g, matrimony vine 2000g, pseudo-ginseng 2000g, lotus leaf 1000g, Poria cocos 5000g, rhizoma alismatis 2000g, hawthorn 1000g, chrysanthemum 6000g, hydroxycitric acid 100g, konjaku powder 700g, l-cn 200g.
Its preparation method such as embodiment 1.
Embodiment 3
Feed proportioning: American Ginseng 6000g, Sessileflower Acanthopanax Bark tea 1000g, oolong tea 5000g, garlic 2000g, matrimony vine 3000g, pseudo-ginseng 5000g, lotus leaf 6000g, Poria cocos 2000g, rhizoma alismatis 3000g, hawthorn 8000g, chrysanthemum 3000g.
Step 1,2,3,4 among its preparation method such as the embodiment 1, the 5th step was:
5) merge dry extract 1, dry extract 2, dry extract 3 and dry extract 4, drying is 3 hours under 50-60 ℃, and it is ground into 200 order powder, is active component of the present invention, is filled into capsule shells by the soft capsule method for production, the De Benming health food.
Embodiment 4
Feed proportioning: American Ginseng 4000g, Sessileflower Acanthopanax Bark tea 3000g, oolong tea 4000g, pseudo-ginseng 4000g, Poria cocos 2500g, rhizoma alismatis 2000g.
Step 1,2 among its preparation method such as the embodiment 1,3, the four steps are:
4) merge dry extract 1, dry extract 2, dry extract 3, drying is 3 hours under 50-60 ℃, and it is ground into 200 order powder, is active component of the present invention, is filled into capsule shells by the soft capsule method for production, the De Benming health food.
It all is medicines that can be used for health food production of ratifying through the Ministry of Public Health, state food and Drug Administration that the formula material of this health food is formed, and meets the theory standard of integration of drinking and medicinal herbs fully, is a kind of " green " health food.
According to " health food check and assessment technique standard " (2003 editions) criterion, show that through zoopery and human experimentation health food of the present invention has tangible weight losing function to the weight losing function health food.
Health food weight losing function of the present invention zoopery and human experimentation the results are shown in experimental example 1 and experimental example 2.
The animal experiment study of 1 health food weight losing function of experimental example is as follows.
1.1 principle
This method is to bring out the animal obesity with high heat food, is tried thing (fat model) again, observes the variation of the weight of animals, body fat content and body health is had harmless.
1.2 instrument
Animal balance, disscting instrument etc.
1.3 test method
1.3.1 animal used as test selects for use body weight to be the adult rat of 180g ± 200g, and is male, 100, available from Animal Experimental Study center, Hubei Province, the quality certification number is the moving word of doctor 2007-0806 number.Every group 10.
1.3.2 dosage grouping is tried thing (health food of present embodiment 1, down with) with adult's recommended amounts oral 720mg/d every day, by adult 60kg batheroom scale, promptly 5 times of 12mg/ (kg body weight) is wherein low dose group, and 10 times is high dose group.Control group adopts blank.Tried thing and given time totally 4 all 30d.
1.3.3 nutrient fodder prescription
Basal feed: pearling cone meal 20%, dehydrated vegetable (removing the cabbage of moisture) 10%, bean powder 20%, yeast 1%, bone meal 5%, corn flour 16%, wheat bran 16%, fish meal 10%, salt 2%.
Nutrient fodder: basal feed 80%, lard 10%, yolk powder 10%.
1.3.4 the fat modelling of experimental procedure: behind nutrient fodder hello rat 30d, the rat of the same age that weight gain is fed than normal diet increases, and difference has conspicuousness, and then the fat model of Jian Liing meets requirement of experiment.After the fat model of rat is set up, be divided into model control group and high and low two at random and tried the thing test group.Test group gives the thing that tried of various dose, and model control group gives coordinative solvent.
1.3.5 observation index body weight, food ration, food utilization, body fat quality (testis and perirenal fat pad).
Table 1 is respectively organized rat growth indexes and Lipid Metabolism Determination value
* P<0.05 of comparing with control group; * and control group be (P<0.01) relatively
A is n=6.
1.3.6 the result is as shown in table 1, high and low dose health products group and control group compare, and the fat weight average obviously reduces around body weight, the genitals, but indifference between the high and low dose group.Under high-power microscope, adipocyte number seen in each visual field, the health products group obviously more than control group, but cell volume is significantly less than control group, illustrate that fatty amount is few in the adipocyte of health products group, cell accumulation together, the cell number of seeing in the therefore same visual field is more.Above result shows, these health products really can reduce fatty accumulation, and in a single day reach effective dose again escalated dose can not make fat-reducing effect better.
1.4 data are handled and the result judges
The body weight of experimental group and body fat quality, or body weight and fat body ratio be lower than model control group, and difference has conspicuousness, and food ration significantly is not lower than model control group, and body is not had obvious damage, and promptly this result of the test of being tried thing animal weight losing function of decidable is positive.
According to " health food check and assessment technique standard " (2003 editions) criterion to the weight losing function health food, this health food of decidable has antiobesity action.
Experimental example 2
The human experiment experimental study of this health food fat-reducing effect is as follows.
2.1 principle
Give the simple obesity experimenter the edible thing (health food of present embodiment 2, down together) that tried, observe body weight, body fat content and body health is had harmless.
2.2 instrument human body component sensing equipment, batheroom scale.
2.3 test method
2.3.1 experimenter's selection study subject is the simple obesity crowd.Become the interior total fatty percentage of human body to reach man>25%, the volunteer of woman>30%.Children and teenager survey body weight 20% of the body weight that is above standard.The experimenter does not have gallbladder disease.
2.3.2 the experimenter that should not participate in the experiment that we confirm merge have the inclination, serious diseases such as liver, kidney and hemopoietic system, the mental patient; Credit is not tried thing in accordance with regulations, can't judge effect or data not umbra sound effect or security judgement person; Take the article relevant in a short time, have influence on result's judgement person with being tried function.
2.3.3 test requirements document
This health food is the weight losing function health food that does not substitute staple food.Control experiment design between own control and group is adopted in the weight losing function test that does not substitute staple food in accordance with regulations.Body weight, body lipid amount by the experimenter are divided into test-meal group and control group at random, consider influence result's principal element such as age, sex, diet, moving situation etc. as far as possible, carry out harmony to check, with the comparativity between the assurance group.Every group of experimenter of test number is no less than 10 examples.
2.3.4 tried the dosage and the using method of thing
This health food is not for substituting the weight losing function health food of staple food: the test-meal group is taken by instructions of taking, the dose recommended and is tried thing, tried thing with adult's recommended amounts oral 720mg/d every day, by adult 60kg batheroom scale, be that 12mg/ (kg body weight) takes, 2 times is low dose group wherein, and 3 times is high dose group.Control group adopts blank.Carry out the test-meal experiment by blind method.Tried thing and given time 30d.
2.3.5 observation index
2.3.5.1 safety indexes
General situation comprises spirit, sleep, diet, stool and urine, blood pressure etc., blood, urine, just routine inspection, liver, kidney function test Chest X-rays, electrocardiogram, Abdominal B type ultrasonography inspection (every index is checked once before experiment), blood uric acid, urine ketoboidies.The exercise tolerance test: the exercise tolerance method of testing is the cycle ergometer test.The experimenter is with identical motion scheme power cycle test before and after the test-meal, recorded heart rate, and use each experimenter's of nomography indirect determination of Sstrand and Ryhming maximal oxygen uptake (L/ branch).Other bad reactions are observed: as apocleisis, diarrhoea etc.
2.3.5.2 dietary factors and motion conditions requirement
The experimenter is carried out the 3d dietary survey before experiment beginning, before the end.In order to get rid of the influence of dietary factor, require consistent with diet as far as possible to result of the test.Observation is inquired in motion to the experimental session experimenter, requires consistent with the daily exercise situation.
2.3.5.3 effect index
Body weight, calculating body mass index, SBW, body fat Determination on content etc. see Table 2 before and after the experiment:
Table 2 is respectively organized human body indicators and Lipid Metabolism Determination value (every group of experimenter of test number 10 examples)
* P<0.05 of comparing with control group; * and control group be (P<0.01) relatively
1.3.6 the result is as shown in table 2, high and low dose health products group and control group compare, and body weight all obviously reduces, but indifference between the high and low dose group.Under high-power microscope, adipocyte number seen in each visual field, the health food group obviously more than control group, but cell volume is significantly less than control group, illustrate that fatty amount is few in the adipocyte of health food group, cell accumulation together, the cell number of seeing in the therefore same visual field is more.Above result shows that this health food really can reduce the accumulation of fat.Carry out overall merit according to These parameters measurement result before and after the test, wherein body fat content is learned processing difference by statistics conspicuousness, and body health is not had obvious damage.
According to " health food check and assessment technique standard " (2003 editions) criterion to the weight losing function health food, this health food of decidable has antiobesity action.

Claims (9)

1. health food with weight losing function, its active component is mainly made by following bulk drugs: American Ginseng 1-6 part, Sessileflower Acanthopanax Bark tea 1-8 part, oolong tea 1-5 part, pseudo-ginseng 1-5 part, Poria cocos 1-5 part, rhizoma alismatis 1-3 part.
2. health food according to claim 1, wherein the weight portion of bulk drug is: 1 part of American Ginseng, 2 parts of Sessileflower Acanthopanax Bark tea, 2 parts in oolong tea, 1 part of pseudo-ginseng, 1 part in Poria cocos, 1 part of rhizoma alismatis.
3. health food according to claim 1 also contains garlic 1-3 part, matrimony vine 1-3 part, lotus leaf 1-6 part, hawthorn 1-8 part, chrysanthemum 1-6 part in the described bulk drug.
4. health food according to claim 3, wherein the weight portion of bulk drug is 1 part in garlic, 1 part of matrimony vine, 3 parts on lotus leaf, 2 parts of hawthorn, 1 part of chrysanthemum.
5. health food according to claim 3 wherein also contains hydroxycitric acid, konjaku powder and l-cn in the active component, its weight portion is hydroxycitric acid 0.1-0.5 part, konjaku powder 0.1-0.7 part, l-cn 0.1-0.3 part.
6. health food according to claim 5,0.2 part of described hydroxycitric acid, 0.3 part of konjaku powder, 0.1 part of l-cn.
7. health food according to claim 6, the formulation of described health food are soft capsule.
8. the preparation method of the described health food of claim 7 comprises the steps:
1) take by weighing American Ginseng, pseudo-ginseng 2 flavor bulk drugs in proportion, with 60% alcohol extract twice, merge the extract vacuum concentrated dry extract 1;
2) take by weighing Poria cocos, rhizoma alismatis 2 flavor bulk drugs in proportion, with 70% alcohol extract twice, merge the extract vacuum concentrated dry extract 2;
3) take by weighing Sessileflower Acanthopanax Bark tea, oolong tea in proportion and extract 1 time with distilled water, with the extract vacuum concentrate dry extract 3;
4) take by weighing garlic, matrimony vine, lotus leaf, hawthorn, chrysanthemum in proportion, extract 1 time with distilled water, with the extract vacuum concentrate dry extract 4;
5) merge dry extract 1, dry extract 2, dry extract 3 and dry extract 4, it be ground into 200 order powder, take by weighing hydroxycitric acid, konjaku powder, l-cn blending in proportion after, make soft capsule according to a conventional method.
9. preparation method according to claim 8, the dry extract that obtains after described the concentrating also need is following dry 3 hours at 50-60 ℃.
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