CN107183705A - A kind of relax bowel improves the functional food of constipation - Google Patents
A kind of relax bowel improves the functional food of constipation Download PDFInfo
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- CN107183705A CN107183705A CN201710233561.XA CN201710233561A CN107183705A CN 107183705 A CN107183705 A CN 107183705A CN 201710233561 A CN201710233561 A CN 201710233561A CN 107183705 A CN107183705 A CN 107183705A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Improve the functional food of constipation the invention discloses a kind of relax bowel, the active component of the functional food includes：20~40 parts of Semen Pruni extract, 20~40 parts of Fructus Cannabis extract, 15~35 parts of dietary fiber, 15~35 parts of aloe extract, 10~30 parts of cassia seed extract.Present invention also offers a kind of preparation method for the functional food for relaxing bowel and improving constipation, comprise the following steps：(1) powder raw material of each active component is put into mixer, stirs, obtain pulverulent mixture；(2) pulverulent mixture is dried and sterilized；(3) 60~100 mesh sieves are crossed, obtaining relaxing bowel for fine-powdered improves the functional food of constipation.By scientific matching, make each active compound synergy of the present invention, complementary mutually rush, given play to powerful and complete effect of relaxing bowel.
Description
Technical field
The present invention relates to field of functional food, the feature food of constipation is improved more particularly, to a kind of relax bowel
Product.
Background technology
With the quickening and the change of dietary structure of modern life rhythm, dietary fiber etc. promotes the food of intestines peristalsis
Intake is reduced, and high protein diet intake is excessive, and physical training in addition is reduced, the factor such as life stress is excessive so that constipation by
Gradually as one of common disease for making modern's puzzlement.Constipation is clinically common chronic digestible tract disease, generally between defecation
Every extension, dry and hard excrement, it is involved and abstruse be not freely cardinal symptom, severe patient can cause electrolyte and disturbance of acid-base balance, cause hemorrhoid,
The diseases such as varix of lower limb.Constipation is more by diet, bowl evacuation habit be bad, intestines peristalsis decline, irritability decline and gradually shape
Into.Toxin in human body, is mainly excreted by excrement.Prolonged constipation, vivotoxin can not be discharged in time, can induce inflammation
The diseases such as disease, tumour；Prolonged constipation can also increase vivotoxin, hinder the increase such as nitric oxide, vasoactive intestinal peptide property fast
Neurotransmitter synthesis, storage, the release of sense；Constipation also results in abdominal distension gas, allows people to produce uncomfortable, causes sexual hypoesthesia.
Functional food refers to the food with trophic function, sensory function and regulation physiological activity function, including：Enhancing
The food of human body constitution, the food for preventing disease, restorative food, adjust body rhythms food and anti-aging food
Product.The research and development of functional food still belong to new branch of science and field in China, are multidisciplinary, multi-field continuous mixing together
Product, be related to nutrition, pharmacy, physiology, preventive medicine, bioengineering, Food Science.
The method of traditional treatment constipation is to take cathartic, but traditional cathartic is generally that dilatancy, excitant, lubricity are rushed down
Medicine, it is poisoned big, long-term taking and easily forms pharmacological dependence, it is also possible to cause intestines melanose, damages enteric nervous system, makes colon
Power weaken, so as to aggravate constipation, impairing the spleen and stomach is totally unfavorable to health.Fail to understand in addition, some cathartics also have curative effect
It is aobvious, the defect that therapeutic domain extremely limits to.It is generally the single product relaxed bowel in the market, though the characteristics of having itself,
But single product is difficult to play powerful complete effect of relaxing bowel.Therefore, develop safely and effectively treatment product into working as
Business is anxious.Medicinal and edible plant is because of its natural source, not habituation, and the advantage such as have no side effect is liked by people, but some
Medicine food product, which also exists, easily to make moist, the problems such as shelf lives are short.
The content of the invention
For the disadvantages described above or Improvement requirement of prior art, the work(of constipation is improved the invention provides a kind of relax bowel
Energy property food, its object is to pass through scientific matching, extracts Semen Pruni extract, Fructus Cannabis extract, dietary fiber, aloe
Thing, the composition synergy of cassia seed extract, complementary mutually rush, so as to by promoting intestines peristalsis, shorten enteral prods and lead to
The modes such as the time of enteron aisle are crossed to improve constipation.
It should be noted that the medical composition and its use of the present invention, which is present inventor, passes through arduous creation
Property work and Optimization Work just complete.
To achieve the above object, the function of constipation is improved there is provided a kind of relax bowel according to one aspect of the present invention
Property food, in terms of parts by weight, the active component of the functional food includes：
20~40 parts of Semen Pruni extract, 20~40 parts of Fructus Cannabis extract, 15~35 parts of dietary fiber, aloe extract
15~35 parts, 10~30 parts of cassia seed extract.
Preferably, in terms of parts by weight, the active component of the functional food includes：
25~35 parts of Semen Pruni extract, 25~35 parts of Fructus Cannabis extract, 20~30 parts of dietary fiber, aloe extract
20~30 parts, 15~25 parts of cassia seed extract.
Preferably, the functional food is at least one form of capsule, tablet or electuary.
Preferably, the functional food is in capsule form, and the capsule includes dietary fiber layer, moistureproof liquid layer, albumen
Film layer, moistureproof liquid layer is located between dietary fiber layer and albumen film layer.
Preferably, the dietary fiber layer is using cereal or fruit as raw material, and moistureproof liquid layer is with granulated sugar, Gorgon fruit, duck wheat, the heart of a lotus seed
Rice, tea stalk, rde bean, cassia seed are raw material, and albumen film layer is using egg as raw material；Dietary fiber thickness degree is 0.5~1mm,
Moistureproof liquid layer thickness is less than 1mm, and albumen thicknesses of layers is 0.5~1mm.
Preferably, in the moistureproof liquid layer raw material granulated sugar, Gorgon fruit, duck wheat, Semen Coicis, tea stalk, rde bean, cassia seed
Mass ratio is 25: 20: 15: 20: 20: 10: 10.
It is another aspect of this invention to provide that there is provided a kind of preparation side for the functional food for relaxing bowel and improving constipation
Method, comprises the following steps：
(1) it is 20~50 parts of Semen Pruni extract, 20~50 parts of Fructus Cannabis extract, 15~50 parts of meals are fine
In dimension, the powder raw material input mixer of 15~40 parts of aloe extract, 10~20 parts of cassia seed extract, stirring is equal
It is even, obtain pulverulent mixture；
(2) pulverulent mixture is dried and sterilized；
(3) pulverulent mixture after drying and sterilizing is crushed, crosses 60~100 mesh sieves, the ease constipation for obtaining fine-powdered is led to
Just the functional food of constipation is improved.
Preferably, the method dried in the step (2) and sterilized is：Pulverulent mixture tiling is put into microwave dryer
It is interior.
Preferably, the ulking thickness that pulverulent mixture tiles in microwave dryer in the step (2) is 2~2.5cm.
Preferably, in the step (2) pulverulent mixture drying and sterilize temperature be 60~80 DEG C, the time be 4~
10min, the moisture after pulverulent mixture drying is less than 7%.
In general, by the contemplated above technical scheme of the present invention compared with prior art, by scientific matching, make
Semen Pruni extract, Fructus Cannabis extract, dietary fiber, aloe extract, the composition of cassia seed extract act synergistically, mutually
Mend and mutually promote, improve constipation, following beneficial effect can be obtained：
(1) shown by the test experiments result to mouse, of the invention relaxing bowel improves the functional food of constipation
With the effect for promoting small intestine push, promoting defecation, shortening first just time, increase feces volume and stool interval；
(2) by human test test result indicates that, of the invention relax bowel improves the functional food of constipation and can had
The defecation frequency of effect increase constipation person, improves the effect of defecation condition and fecal character；And by blood pressure, blood routine, blood
The inspection result of biochemical indicator shows that the sample has no adverse effects to human body Liver and kidney function；
(3) functional food of constipation and the contrast and experiment of substitute composition are improved by relaxing bowel for the present invention
Show, by scientific matching, each active component of the oxidation resistant functional food that the present invention is provided together after, its ink
Juice propulsion rate, feces volume and stool interval have been given play to apparently higher than other combinations, multicomponent functional food of the invention
Stronger more complete effect of relaxing bowel；
(4) functional food of the improvement constipation that relaxes bowel of the invention is made with Semen Pruni extract and Fructus Cannabis extract
For monarch drug in a prescription, play brush-cherry seed and the effect relaxed bowel is cooperateed with fructus cannabis, and fructus cannabis is sweet, can improve brush-cherry seed
Bitter taste so that composition mouthfeel is more preferably；
(5) when the functional food for improving constipation when relaxing bowel is in capsule form, the present invention proposes a kind of including meals
Fibrous layer, moistureproof liquid layer, the capsule of albumen film layer are eaten, the capsule is all prepared from by edible raw material, except can be to prevent
Only functional food of the invention makes moist, moreover it is possible to extend its shelf-life；
(6) effect that the functional food of the improvement constipation that relaxes bowel of the invention also has treatment to cough；
(7) functional food of the improvement constipation that relaxes bowel of the invention can reduce using and relying on to cathartic, reduce
The toxic side effect that medicine is brought to body, relaxes bowel in improvement constipation in safety, can shorten enteral by promoting intestines peristalsis
Time that material passes through enteron aisle etc. improves constipation.
Embodiment
The embodiments described below is exemplary, is only used for explaining the present invention, and it is not intended that to the limit of the present invention
System.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not intended to limit the present invention.
Semen Pruni extract：Brush-cherry seed has dry laxation, lower gas, Li Shui.For intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, abdominal distention constipation,
Oedema, tinea pedis, difficult urination.With moisturize laxation, lower gas row is stagnant, effect of inducing diuresis for removing edema.Brush-cherry seed glucoside pair contained by brush-cherry seed
Experimental animal has strong discharge function.Its similar Sennosides of discharge function mechanism, belongs to large intestine purgatives.But also there is experiment to demonstrate,prove
Bright, brush-cherry seed water extract and its fat oil have extremely significant promotion intestinal motility effect to mouse stomach, brush-cherry seed seed
50% water decoction can substantially shorten constipation type Constipation Model mouse defecation time, and defecation frequency substantially increases.(select from《China is originally
Grass》)
Fructus Cannabis extract：Moisturize laxation, promoting diuresis for stranguria, promoting blood circulation.Main dry constipation of intestines, wandering arthritis, quench one's thirst, geomantic omen, heat gonorrhea, dysentery
Disease, irregular menstruation, sore tinea, erysipelas etc..Fructus cannabis can stimulate intestinal mucosa, increase secretion, wriggle and accelerate, and reduce big intestinal absorption
Moisture, therefore have discharge function.(select from《Chinese book on Chinese herbal medicine》)
Dietary fiber：It is referred to as " the 7th nutrient " by nutrition educational circles, U.S. FDA suggestion in 1998 supplements appropriate meals
Fiber can effectively pre- preventing obesity, diabetes, coronary heart disease, the carcinoma of the rectum, colon cancer etc., dietary fiber is by absorbing the water of stomach enteral
Part, rapid expansion makes human body produce satiety, and reduces intestinal absorption carbohydrate, lipid material, lubricates enteron aisle, promotes defecation,
Suppress fat.
Aloe extract：Aloe has a stomach invigorating and laxative effect, aloe extract contain Barbaloin, aloearbonaside,
The active ingredient such as aloe miaow tincture have stomach invigorating and laxative function, play and improve a poor appetite and large intestine laxative action.Barbaloin
It is the derivative of the glycocide containing anthraquinone, with digestion promoting function, while aloe-emodin is released in enteron aisle, under performance excitant is rushed down
Effect, there is obvious therapeutic action at main function position in large intestine to a variety of constipation.
Cassia seed extract：Cassia seed has heat-clearing improving eyesight, relaxes bowel.For the puckery pain of hot eyes, many tears of photophobia are had a headache dizzy
Dizzy, mesh is secretly failed to understand, constipation.(pluck in《Chinese Pharmacopoeia》)
A kind of relax bowel that the present invention is provided improves the functional food of constipation, in terms of parts by weight, the feature
The active component of food includes：
20~40 parts of Semen Pruni extract, 20~40 parts of Fructus Cannabis extract, 15~35 parts of dietary fiber, aloe extract
15~35 parts, 10~30 parts of cassia seed extract.
Brush-cherry seed and fructus cannabis are all the presently preferred products relaxed bowel, and fructus cannabis, which is nourished, to be moisturized, and effect relaxes, and fits
For the dry constipation of intestines in postpartum before physically weak after being ill and tire, then laxation defecating feces excretion is strong for brush-cherry seed, and energy diuresis, and they can be mutual
Mend.The functional food for improving constipation that relaxes bowel of the present invention using Semen Pruni extract and Fructus Cannabis extract as monarch drug in a prescription,
Play brush-cherry seed and the effect relaxed bowel is cooperateed with fructus cannabis, and fructus cannabis is sweet, can improve Semen Pruni extract
Bitter taste so that composition mouthfeel is more preferably.The functional food of the inoxidizability of the present invention can shorten intestines by promoting intestines peristalsis
Time that interior material passes through enteron aisle etc. improves constipation.
Brush-cherry seed and fructus cannabis belong to need to be positioned over the plant preserved at shady and cool dry, are fabricated to after food
Moisture protection is should be noted, for the problem, the present invention proposes a kind of including dietary fiber layer, moistureproof liquid layer, albumen film layer
Capsule.Wherein, dietary fiber layer is using cereal or fruit as raw material, and moistureproof liquid layer is with granulated sugar, Gorgon fruit, duck wheat, Semen Coicis, tea
Stalk, rde bean, cassia seed are raw material, and albumen film layer is using egg as raw material.The capsule all prepared by edible raw material and
Into, and granulated sugar, Gorgon fruit, duck wheat, Semen Coicis, tea stalk, rde bean, cassia seed etc. itself have water suction moisture-proof function, can prevent
The functional food of the present invention makes moist, while the capsule can be with the shelf-life of extension function food.
It is too thick or too thin can influence moisture-proof role and drug effect in view of packaging film thickness.Preferably, therefore, meals
Fiber layer thickness is 0.5~1mm, and moistureproof liquid layer thickness is less than 1mm, and albumen thicknesses of layers is 0.5~1mm.
Preferably, in moistureproof liquid layer raw material granulated sugar, Gorgon fruit, duck wheat, Semen Coicis, tea stalk, rde bean, the quality of cassia seed
Than for 25：20：15：20：20：10：10.Moisture effect under this ratio is optimal, is more beneficial for the preservation of food.
In addition, the invention provides a kind of preparation method for the functional food for relaxing bowel and improving constipation, it is including following
Step：
(1) it is 20~40 parts of Semen Pruni extract, 20~40 parts of Fructus Cannabis extract, 15~35 parts of meals are fine
In dimension, the powder raw material input mixer of 15~35 parts of aloe extract, 10~30 parts of cassia seed extract, stirring is equal
It is even, obtain pulverulent mixture；
(2) pulverulent mixture is dried and sterilized；
(3) pulverulent mixture after drying and sterilizing is crushed, crosses 60~100 mesh sieves, the ease constipation for obtaining fine-powdered is led to
Just the functional food of constipation is improved.
Compared to traditional drying mode (hot blast, steam, electrical heating etc.), microwave drying can realize the pollution-free and equal of material
Even drying, rate of drying can be improved more than several times；Energy consumption for drying can reduce by more than 50%.Preferably, therefore, the step (2)
In pulverulent mixture be put into microwave dryer.
Wherein Semen Pruni extract, Fructus Cannabis extract, aloe extract, cassia seed extract were bought from Xi'an day all one's life
Thing technical concern Co., Ltd, dietary fiber is bought from Beijing Jia Kang sources Chemical Co., Ltd..
According to some specific embodiments of the present invention, the present invention establishes a kind of Constipated mice, to the profit of the present invention
The functional food that intestines defaecation improves constipation has carried out functional experiment, it is found that one kind that the present invention is provided relaxes bowel improvement just
Secret functional food all has significant promotion intestines peristalsis to mouse small intestine exercise testing and defecation experiment, and intestines defaecation improves
Constipation is acted on, at the same time, the present invention also foundation《Health food is examined and assessment technique specification》(version in 2003) is to the present invention
A kind of functional food for relaxing bowel improvement constipation provided has carried out Oral toxicity experiment, binomial mutagenicity test (mouse
Polychromatic erythrocyte number micronucleus test and sperm malformation test) and 30 days feeding trials safety evaluatio experiment, experiment
Show, by acute toxicity grading criteria evaluation, the given the test agent belongs to nontoxic level.
Embodiment 1：
There is provided a kind of relax bowel improves the functional food of constipation, is mixed and made by the active component of following parts by weight
Into：30 parts of Semen Pruni extract, 25 parts of Fructus Cannabis extract, 15 parts of dietary fiber, 20 parts of aloe extract, cassia seed extract
10 parts of powder raw materials.
Embodiment 2：
There is provided a kind of relax bowel improves the functional food of constipation, is mixed and made by the active component of following parts by weight
Into：30 parts of Semen Pruni extract, 20 parts of Fructus Cannabis extract, 20 parts of dietary fiber, 20 parts of aloe extract, cassia seed extract
10 parts of powder raw materials.
Embodiment 3：
There is provided a kind of relax bowel improves the functional food of constipation, is mixed and made by the active component of following parts by weight
Into：30 parts of Semen Pruni extract, 20 parts of Fructus Cannabis extract, 15 parts of dietary fiber, 15 parts of aloe extract, cassia seed extract
20 parts of powder raw materials.
Embodiment 4：
There is provided a kind of relax bowel improves the functional food of constipation, is mixed and made by the active component of following parts by weight
Into：40 parts of Semen Pruni extract, 20 parts of Fructus Cannabis extract, 15 parts of dietary fiber, 15 parts of aloe extract, cassia seed extract
10 parts of powder raw materials.
Embodiment 5：
There is provided a kind of relax bowel improves the functional food of constipation, is mixed and made by the active component of following parts by weight
Into：20 parts of Semen Pruni extract, 40 parts of Fructus Cannabis extract, 15 parts of dietary fiber, 15 parts of aloe extract, cassia seed extract
10 parts of powder raw materials.
Embodiment 6：
There is provided a kind of relax bowel improves the functional food of constipation, is mixed and made by the active component of following parts by weight
Into：20 parts of Semen Pruni extract, 20 parts of Fructus Cannabis extract, 35 parts of dietary fiber, 15 parts of aloe extract, cassia seed extract
10 parts of powder raw materials.
Embodiment 7：
There is provided a kind of relax bowel improves the functional food of constipation, is mixed and made by the active component of following parts by weight
Into：20 parts of Semen Pruni extract, 20 parts of Fructus Cannabis extract, 15 parts of dietary fiber, 15 parts of aloe extract, cassia seed extract
30 parts of powder raw materials.
Embodiment 8：
Improve the preparation method of constipation there is provided a kind of relax bowel
To first meet standard (quality standard, as follows in Q/WHF 00007S-2012) 30 parts of Semen Pruni extract,
25 parts of Fructus Cannabis extract, 15 parts of dietary fiber, 20 parts of aloe extract, 10 parts of powder raw material (parts by weight of cassia seed extract
Number) put into mixer, it is allowed to stir, and control raw material moisture content to be 15%；Again by the raw material mixed by 2cm's
Thickness is uniformly laid in microwave dryer, is sterilized and is dried under the conditions of temperature 70 C, time 6min, moisture after drying
Content 6%；Then, the powder raw material after drying and sterilizing is crushed, crosses 80 mesh sieves, obtain fine powder；Finally, according to national work(
Tablet is made in fine powder raw material by the food technology requirement of energy property.
Embodiment 9：
Improve the preparation method of constipation there is provided a kind of relax bowel
First by 25 parts of standard compliant powder raw material (parts by weight) Semen Pruni extract, 25 parts of Fructus Cannabis extract, meals
Eat in 25 parts of fiber, 15 parts of aloe extract, 10 parts of input mixers of cassia seed extract, be allowed to stir, and control original
It is 15% to expect water content；Following process be the same as Example 8.
Embodiment 10：
Improve the preparation method of constipation there is provided a kind of relax bowel
First by 25 parts of standard compliant powder raw material (parts by weight) Semen Pruni extract, 25 parts of Fructus Cannabis extract, meals
Eat in 15 parts of fiber, 15 parts of aloe extract, 20 parts of input mixers of cassia seed extract, be allowed to stir, and control original
It is 15% to expect water content；Following process be the same as Example 8.
Embodiment 11：
Improve the preparation method of constipation there is provided a kind of relax bowel
First by 25 parts of standard compliant powder raw material (parts by weight) Semen Pruni extract, 20 parts of Fructus Cannabis extract, meals
Eat in 20 parts of fiber, 20 parts of aloe extract, 15 parts of input mixers of cassia seed extract, be allowed to stir, and control original
It is 15% to expect water content；Following process be the same as Example 8.
Embodiment 12：
Improve the preparation method of constipation there is provided a kind of relax bowel
To first meet standard (quality standard, as follows in Q/WHF 00066S-2015) 30 parts of Semen Pruni extract,
25 parts of Fructus Cannabis extract, 15 parts of dietary fiber, 20 parts of aloe extract, 10 parts of powder raw material (parts by weight of cassia seed extract
Number) put into mixer, it is allowed to stir, and control raw material moisture content to be 15%；Again by the raw material mixed by 2cm's
Thickness is uniformly laid in microwave dryer, is sterilized and is dried under the conditions of temperature 70 C, time 6min, moisture after drying
Content is less than 7%；Then, the powder raw material after drying and sterilizing is crushed, sieves, 80 mesh sieves can be used during sieving, are obtained carefully
Powder；Include dietary fiber layer, moistureproof liquid layer, egg in one layer of the functional food outer wrapping of the improvement constipation that relaxes bowel of fine-powdered
The packaging film of tunica albuginea layer, moistureproof liquid layer is located between dietary fiber layer and albumen film layer, and dietary fiber thickness degree is 0.5~1mm,
Moistureproof liquid layer thickness is less than 1mm, and albumen thicknesses of layers is 0.5~1mm.Dietary fiber layer using cereal or fruit as raw material,
Filter, deaerate after clean, mashing, crushing, smearing；Moistureproof liquid layer with granulated sugar, Gorgon fruit, duck wheat, Semen Coicis, tea stalk, rde bean, certainly
Pine torch is raw material, and chitosan stirring is added after decoction, filtering and concentrating；Albumen film layer using egg as raw material, boil, filter after plus
Enter amyloid proteins paste well mixed, add auxiliary additive stirring.
Embodiment 13：Relaxing bowel for the present invention improves experiment test of the functional food to mouse of constipation
The present inventor is carried out by being tested to mouse small intestine exercise testing and defecation to the composition of the present invention
Functional experiment is tested.
1. materials and methods
1.1 material
1.1.1 sample
The functional food of constipation is improved using a kind of relax bowel described in the above embodiment of the present invention 1, it is (military by Kai Ze
The Chinese) offer of health control Co., Ltd, human body recommended amounts are 50mg/ (dkg).
1.1.2 experimental animal
Experimental animal is 18~22g Healthy female Kunming mouses, and by Hubei Province, Experimental Animal Center is provided, and is freely taken the photograph
Food, drinking-water.
1.1.3 reagent
The preparation of prepared Chinese ink：Gum arabic 100g accurately is weighed, add water 800mL, boil transparent to solution, weigh activated carbon
(powdery) 50g is added to be boiled three times in above-mentioned solution, and 1000mL is settled to after being added water after solution cooling, and 4 DEG C of refrigerators are preserved, before
Shake up.
Compound phenol promise ester suspension preparation：Compound ground phenol promise ester piece, every, containing compound ground phenol promise ester 2.5mg, takes multiple
Side ground phenol promise ester piece 25mg or 50mg (10 or 20), it is in add water to 100mL after powder to be ground with mortar, prepared before use into
Concentration is 0.025% suspension.
1.1.4 statistical method
Test data carries out statistical disposition with variance analysis, and each group of data is usedRepresent, using the softwares of SPSS 20.0
Carry out data analysis.P<0.05 is significant difference, statistically significant.Under the premise of Constipated mice establishment, 6h defecations grain
Any one of number and defecation weight result are positive, while any one of intestinal motility experiment and defecation time result are positive, can determine that this
Tested material has function of relaxing bowel.
1.2 experimental method
1.2.1 dosage and packet
Animal is randomly divided into several groups by body weight, every group 10, if 10,5 (middle dose groups, equivalent to human body recommended amounts
10 times) and 3 experimental groups of 2.5g/kg.w and 1 negative control group, sample prepared with distilled water, daily oral gavage, gavage
Volume 20ml/kg b.w t., control group fills distilled water, continuous 8d.All animals give mouse full-valence pellet feed.
1.2.2 small intestine push is tested
Before on-test, animal fasting 24h (free water therebetween), experimental group and control group give tested material or double respectively
Steam water 1 time, each group orally administration prepared Chinese ink after 30min.Give prepared Chinese ink and cervical vertebra execution is taken off after 30 minutes.Clip upper end from orifice of the stomach, under
Intestinal tube is gently pulled into straight line, measurement Length of intestine is " intestinal tube total length ", from orifice of the stomach to rectum root intestinal tube by end on tray
It is prepared Chinese ink " propulsion length " to prepared Chinese ink forward position, calculates ink progradation：
Ink progradation (%)=prepared Chinese ink promotes length (cm)/intestinal tube total length (cm) × 100.
1.2.3 mouse defecation is tested
Each group animal fasting 24h (free water therebetween) before experiment, each group gavage is with giving compound in addition to blank control group
The fragrant suspension of promise ester 0.025% sets up Constipation Model, gives 1h after compound diphenoxylate, and basic, normal, high dosage group is finally given 1 time
Tested material, control group gives distilled water.Each group orally administration prepared Chinese ink after 30min.The equal single cage feedwater of each group animal, food, observation
Record every animal first just time, 8h defecations grain number and defecation weight.
2 results
2.1 small intestine push are tested
From table 1, sample is in 2.5,5 and 10g/kg b.w dosage, and each experimental group prepared Chinese ink compared with control group is promoted
Rate is improved, and high dose group propulsion rate improves 21%, is statistically analyzed, there is significant difference (P<0.05) a kind of profit, is shown
The functional food that intestines defaecation improves constipation has promotion Constipation.
A kind of influence of the functional food for improving constipation that relaxes bowel of table 1 to mouse small intestine ink progradation
2.2 mouse defecations are tested
From table 2, Constipation Model group first just (P of time lengthening 306% compared with Normal group<0.01), 8 defecation weight
Amount reduces by 73% (P<0.01), 8h defecations grain number reduces by 84% (P<0.01).Experimental group in 2.5,5 and 10g/kg dosage,
Compared with Constipation Model group, the first just time advance of each dosage group, respectively with conspicuousness and pole significant difference (P<0.05, P<
0.01)；Each dosage group defecation weight increase in 8 hours, wherein low, middle dose group has pole significant difference (P<0.01)；Each dose
Amount group 8h defecations grain number is more than Constipation Model group, and high, middle dose group has conspicuousness and pole significant difference (P respectively<
0.05, P<0.01).Show that a kind of functional food for improving constipation that relaxes bowel, with Constipation Model mouse defecation is promoted, contracts
Short first just time, the effect of increase feces volume and stool interval.
Table 2 is a kind of relax bowel improve the functional food of constipation to the small mouse's head of Constipation Model just the time, defecation grain number and
The influence (x ± s) of excrement weight
Note：1. every group of animal is 10.2.*P<0.05, * * P<0.01 (being compared with Constipation Model group), * * * constipation moulds
Type P compared with blank control group<0.01, show that Constipation Model is built up.
Test result indicates that, the functional food that of the invention relaxing bowel improves constipation has promotion small intestine push and rush
Enter defecation, shorten the first just time, the effect of increase feces volume and stool interval points out a kind of relax bowel to improve the function of constipation
Property food have relax bowel improve constipation effect.
Embodiment 14：A kind of relax bowel of the present invention improves experiment test of the functional food to human body of constipation.
1 material and method
1.1 sample
A kind of relax bowel that test-meal group takes the offer of embodiments of the invention 1 improves the functional food of constipation, 3.0g/
d。
1.2 experimental design
Non-organic constipation person 100 is selected, is divided into test-meal group and each 50 of control group, two is compareed between group using itself
Plant experimental design.Test-meal group and control are randomly divided into by the constipation symptom (defecation frequency, defecation condition, fecal character) of subject
Group, as far as possible in view of influenceing principal element such as age, sex, diet, constipation reason etc. of result, carries out harmonious inspection
Test, to ensure the comparativity between group.Test-meal group, which takes a kind of relax bowel, improves the functional food of constipation, 3.0g/d.7 days
Afterwards, defecation frequency, the change of 3 efficacy measures of defecation condition and fecal character before and after two groups of experiments are compared, promoting circulation of blood routine of going forward side by side,
Liver and kidney function and electrocardiogram and the superfine security inspections of belly b.
1.3 statistical method
All data are usedRepresent, data analysis is carried out using the softwares of SPSS 20.0.
2 results
Influence of 2.1 tested materials to constipation crowd's efficiency index
After test-meal, the average defecation frequency weekly of test-meal group crowd is more than control group, and difference has very significant (P<
0.01)；The average integral of defecation condition and the average integral of fecal character are significantly lower than control group, and difference is respectively provided with and extremely shown
Work property (P<0.01), test group total effective rate is 92.2%, has very significant P with 13.7% comparing difference of control group<
0.01) 3~6, are shown in Table, shows that the sample has the defecation frequency of increase constipation person, improves the work of defecation condition and fecal character
With.
The defecation frequency daily per capita of two groups of crowds compares before and after the test-meal of table 3
Average each defecation condition score value of two groups of crowds compares after the test-meal of table 4
Average each fecal character score value of two groups of crowds compares after the test-meal of table 5
The sample of table 6 improves effective situation to the secret disease of just shape
Influence of 2.2 tested materials to constipation crowd's safety indexes
Before and after test-meal, test group and the blood pressure, blood routine, the equal nothing of blood parameters inspection result difference of control group crowd
Conspicuousness (P>0.05), and in range of normal value, electrocardiogram and belly b are super
It is without exception, show that the sample has no adverse effects to human body Liver and kidney function.
Embodiment 15：The contrast reality of a kind of the relax bowel functional food and substitute composition that improve constipation of the present invention
Test
Contrast test 1：30 parts of Semen Pruni extracts are replaced with 30 portions of maltodextrins, other components are same as Example 1；
Contrast test 2：25 Fructus Cannabis extracts are replaced with 25 portions of maltodextrins, other components are same as Example 1；
Contrast test 3：15 parts of dietary fibers are replaced with 15 portions of maltodextrins, other components are same as Example 1；
Contrast test 4：20 parts of aloe extracts are replaced with 20 portions of maltodextrins, other components are same as Example 1；
Contrast test 5：10 parts of cassia seed extracts are replaced with 10 portions of maltodextrins, other components are same as Example 1；
Contrast test 6：Composition prepared by embodiment 1 is replaced with maltodextrin.
According to the experimental test procedures of embodiment 1, by 60 mouse (18~22g Healthy female Kunming mouses, by Hubei
Save Experimental Animal Center to provide, freely ingest, drink water) be randomly divided into 6 groups, every group 10, according to embodiment 1, contrast experiment 1~
6 active component formula (5g/kg.w) carries out contrast test.
A kind of influence (x ± s) of the functional food for improving constipation that relaxes bowel of table 7 to mouse small intestine ink progradation
Table 8 is a kind of relax bowel improve the functional food of constipation to the small mouse's head of Constipation Model just the time, defecation grain number and
The influence (x ± s) of excrement weight
Shown by the data result of table 7 and table 8, the present invention provide relax bowel improve constipation functional food it is each
Individual active component synergy, mutually promotees mutually to enter, relative to other contrast tests, the ink progradation of embodiment 1 is higher, head just when
Between it is shorter, feces volume and stool interval are more frequent, and effect that the functional food that provides of the present invention relaxes bowel is significantly better than
Contrast groups.
Embodiment 16：Effect of the functional food treatment cough for improving constipation that relaxes bowel of the present invention
Cough is a kind of protectiveness respiration reflex action of human body.Point in respiratory tract can be effectively removed by cough reflex
Secretion or the foreign matter for entering air flue.But cough also has unfavorable one side, acutely cough can cause hemorrhage from respiratory tract, such as long-term, frequency
It is numerous, violent cough influence work, rest, or even cause laryngalgia, sound is mute and breathes myalgia, then belongs to pathological phenomenon.The present embodiment leads to
Cross effect that the functional food of the present invention is detected to human test for treatment cough.
Test method 1
100 cough patients are randomly selected as subject, M-F is 1：1, the age, subject was every at 3~75 years old
People takes 2~3g of functional food as prepared by the formula of embodiment 1 daily, continuously takes two weeks, and the 1st, 7,14 days
Questionnaire follow-up investigation is carried out, to observe practical effect.
Criterion of therapeutical effect：
1) it is clearly better：
The symptom subjects such as cough, dry throat, pharyngalgia, dys-expectoration, unsmooth breath, throat foreign body sensation, which feel, substantially to be changed
Kind, sense of discomfort, which is substantially all, to be reduced or eliminated, situation about not deteriorating further；
2) alleviated：
The symptoms such as cough, dry throat, pharyngalgia, dys-expectoration, unsmooth breath, throat foreign body sensation have major part to be able to mitigate or disappear
Remove, partial symptoms improve unobvious；
3) DeGrain：
The symptoms such as cough, dry throat, pharyngalgia, dys-expectoration, unsmooth breath, throat foreign body sensation almost change without fairly obvious
See.
A kind of functional food for improving constipation that relaxes bowel of table 9 is to human body treatment of cough result
When just starting to take the functional food prepared by the formula of embodiments of the invention 1 as can be seen from Table 9, effect
Not fairly obvious, it is 9.00% to take first day total effective rate, continuously takes curative effect after 7 days and is substantially substantially improved, total effective
Rate is 65.00%, and the total effective rate continuously taken two weeks is 81.00%.It in summary it can be seen, the improvement that relaxes bowel of the invention
The functional food of constipation has effects that treatment cough.
Test method 2
Subject, which takes relaxing bowel as prepared by the formula of embodiment 1, improves the functional food of constipation, 2~3g/
D, continuously takes two weeks.
Model case：
1st, Liu, man, 31 years old, workman.
2 wheat harvesting periods come, the few phlegm of cough, and evening is often because cough has difficulty in going to sleep.Patient's paroxysmal is acutely coughed, thin lingual fur
White matter is light red, weak pulse and delay.Using the functional food 6 days of the embodiment of the present invention 1, cough is significantly alleviated, and dry mouth and throat takes a turn for the better.After
Continuous to take 3, cough takes a turn for the better most, and night can sleep peacefully, and sleep quality is preferable.Continue to take 4, all diseases totally disappeared, patient's recovery from illness.
2nd, certain is gone into business, female, 6 years old.
Before 3 days, suddenly heating, cough, patient breath with cough constantly, generate heat, 38.2 DEG C of body temperature, thin white fur of tongue, veins string using a left side as
Substantially.Take the functional food of the embodiment of the present invention 24, cough, heating subtract greatly.Continue to take 5, cough is significantly slow
Solution, body temperature is normal.
3rd, what certain, man, 58 years old.
Cough is more than 5 years, and abundant expectoration is thin, the greasy neatly of the white tongue of tongue, and pulse condition sinks string.Take the feature food of the embodiment of the present invention 3
Product 8 days, decrescence, amount of expectoration is also few for cough, and sleep state takes a turn for the better.Continue to take 10, cough is gradually put down, deficiency of food abundant expectoration.Continue to take
15, all diseases totally disappeared, patient's recovery from illness.
It in summary it can be seen, the functional food that of the invention relaxing bowel improves constipation has effects that treatment cough.
As it will be easily appreciated by one skilled in the art that the foregoing is merely illustrative of the preferred embodiments of the present invention, it is not used to
The limitation present invention, any modifications, equivalent substitutions and improvements made within the spirit and principles of the invention etc., it all should include
Within protection scope of the present invention.
Claims (9)
1. a kind of relax bowel improves the functional food of constipation, it is characterised in that in terms of parts by weight, the functional food
Active component include：
20~40 parts of Semen Pruni extract, 20~40 parts of Fructus Cannabis extract, 15~35 parts of dietary fiber, aloe extract 15~
35 parts, 10~30 parts of cassia seed extract.
2. a kind of relax bowel according to claim 1 improves the functional food of constipation, it is characterised in that with parts by weight
Number meter, the active component of the functional food includes：
25~35 parts of Semen Pruni extract, 25~35 parts of Fructus Cannabis extract, 20~30 parts of dietary fiber, aloe extract 20~
30 parts, 15~25 parts of cassia seed extract.
3. a kind of relax bowel according to claim 1 or 2 improves the functional food of constipation, it is characterised in that described
Functional food is at least one form of capsule, tablet or electuary.
4. a kind of preparation method of functional food for improving constipation that relaxes bowel according to claim 1 or 2, its feature
It is, the functional food is in capsule form, the capsule includes dietary fiber layer, moistureproof liquid layer, albumen film layer, petrifying liquid
Layer is located between dietary fiber layer and albumen film layer.
5. the preparation method of the functional food according to claim 4 that improve constipation that relaxes bowel, it is characterised in that institute
State dietary fiber layer using cereal or fruit as raw material, moistureproof liquid layer with granulated sugar, Gorgon fruit, duck wheat, Semen Coicis, tea stalk, rde bean, certainly
Pine torch is raw material, and albumen film layer is using egg as raw material；Dietary fiber thickness degree is 0.5~1mm, and moistureproof liquid layer thickness is less than
1mm, albumen thicknesses of layers is 0.5~1mm.
6. a kind of preparation method of functional food for improving constipation that relaxes bowel according to any one of Claims 1 to 5,
It is characterised in that it includes the following steps：
(1) by 20~40 parts of Semen Pruni extract, 20~40 parts of Fructus Cannabis extract, 15~35 parts of dietary fiber, 15
In~35 parts of aloe extract, the powder raw material input mixer of 10~30 parts of cassia seed extract, stir, obtain
Pulverulent mixture；
(2) pulverulent mixture is dried and sterilized；
(3) pulverulent mixture after drying and sterilizing is crushed, crosses 60~100 mesh sieves, obtain relaxing bowel for fine-powdered and change
The functional food of kind constipation.
7. the preparation method of the functional food according to claim 6 that improve constipation that relaxes bowel, it is characterised in that institute
Stating the method dried and sterilized in step (2) is：Pulverulent mixture tiling is put into microwave dryer.
8. the preparation method of the functional food according to claim 7 that improve constipation that relaxes bowel, it is characterised in that institute
It is 2~2.5cm to state the ulking thickness that pulverulent mixture tiles in microwave dryer in step (2).
9. the preparation method of the functional food according to claim 6 that improve constipation that relaxes bowel, it is characterised in that institute
The temperature stated the drying of pulverulent mixture in step (2) and sterilized is 60~80 DEG C, and the time is 4~10min, and pulverulent mixture dries
Moisture after dry is less than 7%.
Within protection domain.
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| CN109007832A (en) * | 2018-08-13 | 2018-12-18 | 王鸿雁 | A kind of health food and preparation method thereof with effect of relaxing bowel |
| CN109393478A (en) * | 2018-10-19 | 2019-03-01 | 太和县三九药业有限公司 | A kind of energy defaecation aloe powder peach kernel cassia seed angelica capsules |
| CN109481561A (en) * | 2018-12-28 | 2019-03-19 | 安徽全康药业有限公司 | A kind of aloe cassia seed capsule and preparation method thereof of energy relaxing bowels to lose weight |
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| CN110013009A (en) * | 2019-03-07 | 2019-07-16 | 东方药林药业有限公司 | A kind of composition and preparation method thereof with function of relaxing bowel |
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| CN109007832A (en) * | 2018-08-13 | 2018-12-18 | 王鸿雁 | A kind of health food and preparation method thereof with effect of relaxing bowel |
| CN109393478A (en) * | 2018-10-19 | 2019-03-01 | 太和县三九药业有限公司 | A kind of energy defaecation aloe powder peach kernel cassia seed angelica capsules |
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| CN110522040A (en) * | 2019-07-22 | 2019-12-03 | 福建海兴保健食品有限公司 | A kind of green alga dietary fiber adds Chinese medicine relax bowel and defecation meal replacement powder formula |
| CN112655875A (en) * | 2019-10-16 | 2021-04-16 | 刘东华 | Radish cellulose |
| CN111771971A (en) * | 2020-07-23 | 2020-10-16 | 江西人之初乳品营养有限公司 | Composition beneficial to regulating intestinal tract, promoting digestion and improving constipation and preparation method thereof |
| CN112544920A (en) * | 2020-12-03 | 2021-03-26 | 山东腾贵医药有限公司 | Composition for improving constipation and preparation method thereof |
| CN113785948A (en) * | 2021-09-14 | 2021-12-14 | 三原利华生物技术有限公司 | Solid beverage capable of benefiting qi, promoting production of body fluid and relaxing bowel and preparation method thereof |
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Application publication date: 20170922 |