CN113769029A - A medicinal and edible homologous herbal composition for improving intestinal absorption and immune function - Google Patents
A medicinal and edible homologous herbal composition for improving intestinal absorption and immune function Download PDFInfo
- Publication number
- CN113769029A CN113769029A CN202111176126.0A CN202111176126A CN113769029A CN 113769029 A CN113769029 A CN 113769029A CN 202111176126 A CN202111176126 A CN 202111176126A CN 113769029 A CN113769029 A CN 113769029A
- Authority
- CN
- China
- Prior art keywords
- parts
- medicinal
- herbal composition
- immune function
- intestinal absorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 78
- 230000036737 immune function Effects 0.000 title claims abstract description 43
- 230000031891 intestinal absorption Effects 0.000 title claims abstract description 34
- 239000003814 drug Substances 0.000 claims abstract description 71
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 27
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 26
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 26
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 26
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 26
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 26
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 26
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 26
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 26
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 26
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 26
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims abstract description 26
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000002994 raw material Substances 0.000 claims abstract description 21
- 229940079593 drug Drugs 0.000 claims description 30
- 244000183685 Citrus aurantium Species 0.000 claims description 26
- 235000007716 Citrus aurantium Nutrition 0.000 claims description 26
- 241000245665 Taraxacum Species 0.000 claims description 26
- 241001092040 Crataegus Species 0.000 claims description 25
- 241000220259 Raphanus Species 0.000 claims description 25
- 235000005976 Citrus sinensis Nutrition 0.000 claims description 23
- 244000185386 Thladiantha grosvenorii Species 0.000 claims description 23
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 claims description 23
- 210000003038 endothelium Anatomy 0.000 claims description 23
- 244000197580 Poria cocos Species 0.000 claims description 22
- 235000008599 Poria cocos Nutrition 0.000 claims description 22
- 230000002496 gastric effect Effects 0.000 claims description 22
- 239000008187 granular material Substances 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 12
- 238000009825 accumulation Methods 0.000 claims description 9
- 239000006187 pill Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000000084 colloidal system Substances 0.000 claims description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 239000007937 lozenge Substances 0.000 claims description 3
- 239000008188 pellet Substances 0.000 claims description 3
- 239000007901 soft capsule Substances 0.000 claims description 3
- 208000011580 syndromic disease Diseases 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- -1 decoction Substances 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000006072 paste Substances 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 43
- 238000010521 absorption reaction Methods 0.000 abstract description 12
- 210000002175 goblet cell Anatomy 0.000 abstract description 12
- 230000000144 pharmacologic effect Effects 0.000 abstract description 9
- 210000002919 epithelial cell Anatomy 0.000 abstract description 7
- 238000002474 experimental method Methods 0.000 abstract description 6
- 238000012423 maintenance Methods 0.000 abstract description 5
- 241001619461 Poria <basidiomycete fungus> Species 0.000 abstract description 4
- 244000088415 Raphanus sativus Species 0.000 abstract description 2
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 27
- 210000002784 stomach Anatomy 0.000 description 25
- 235000013305 food Nutrition 0.000 description 17
- 230000000968 intestinal effect Effects 0.000 description 16
- 210000000952 spleen Anatomy 0.000 description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 14
- 208000024891 symptom Diseases 0.000 description 14
- 230000029087 digestion Effects 0.000 description 13
- 201000006549 dyspepsia Diseases 0.000 description 12
- 230000006870 function Effects 0.000 description 12
- 230000036541 health Effects 0.000 description 12
- 230000009102 absorption Effects 0.000 description 11
- 201000010099 disease Diseases 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 206010010774 Constipation Diseases 0.000 description 10
- 230000036407 pain Effects 0.000 description 10
- 230000001737 promoting effect Effects 0.000 description 10
- 208000004998 Abdominal Pain Diseases 0.000 description 9
- 210000004185 liver Anatomy 0.000 description 9
- 230000001105 regulatory effect Effects 0.000 description 9
- 230000036039 immunity Effects 0.000 description 8
- 206010000060 Abdominal distension Diseases 0.000 description 7
- 235000009508 confectionery Nutrition 0.000 description 7
- 230000013872 defecation Effects 0.000 description 7
- 210000000936 intestine Anatomy 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 235000013336 milk Nutrition 0.000 description 7
- 210000004080 milk Anatomy 0.000 description 7
- 239000008267 milk Substances 0.000 description 7
- 238000011160 research Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 208000018522 Gastrointestinal disease Diseases 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 235000015097 nutrients Nutrition 0.000 description 5
- 235000019640 taste Nutrition 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 239000009711 Huoxiang-zhengqi Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 206010057190 Respiratory tract infections Diseases 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 230000036528 appetite Effects 0.000 description 4
- 235000019789 appetite Nutrition 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 4
- 235000005686 eating Nutrition 0.000 description 4
- 230000003871 intestinal function Effects 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 230000008855 peristalsis Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 244000063299 Bacillus subtilis Species 0.000 description 3
- 235000014469 Bacillus subtilis Nutrition 0.000 description 3
- 241000287828 Gallus gallus Species 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 235000019525 fullness Nutrition 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 210000004347 intestinal mucosa Anatomy 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 230000002040 relaxant effect Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 210000000813 small intestine Anatomy 0.000 description 3
- 238000002791 soaking Methods 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 2
- 241000282461 Canis lupus Species 0.000 description 2
- 241000657480 Crataegus pinnatifida Species 0.000 description 2
- 235000017159 Crataegus pinnatifida Nutrition 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 208000032139 Halitosis Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 241001058321 Taraxacum sinicum Species 0.000 description 2
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 239000006286 aqueous extract Substances 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 235000006694 eating habits Nutrition 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 206010016766 flatulence Diseases 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 235000012631 food intake Nutrition 0.000 description 2
- 239000010794 food waste Substances 0.000 description 2
- 230000005176 gastrointestinal motility Effects 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 230000004682 mucosal barrier function Effects 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 231100000956 nontoxicity Toxicity 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 235000011888 snacks Nutrition 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- SUVMJBTUFCVSAD-UHFFFAOYSA-N sulforaphane Chemical compound CS(=O)CCCCN=C=S SUVMJBTUFCVSAD-UHFFFAOYSA-N 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- SUVMJBTUFCVSAD-JTQLQIEISA-N 4-Methylsulfinylbutyl isothiocyanate Natural products C[S@](=O)CCCCN=C=S SUVMJBTUFCVSAD-JTQLQIEISA-N 0.000 description 1
- HOMSOWZTBJWNHP-UHFFFAOYSA-N 5-chlorothiadiazole Chemical compound ClC1=CN=NS1 HOMSOWZTBJWNHP-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 235000000228 Citrus myrtifolia Nutrition 0.000 description 1
- 235000016646 Citrus taiwanica Nutrition 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 241000219104 Cucurbitaceae Species 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 206010015137 Eructation Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010019375 Helicobacter infections Diseases 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 240000005856 Lyophyllum decastes Species 0.000 description 1
- 235000013194 Lyophyllum decastes Nutrition 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 241001522129 Pinellia Species 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- 206010038084 Rectocele Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 235000004789 Rosa xanthina Nutrition 0.000 description 1
- 241000220222 Rosaceae Species 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241001558929 Sclerotium <basidiomycota> Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000292546 Taraxacum mongolicum Species 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 210000000702 aorta abdominal Anatomy 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 208000027687 belching Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004534 cecum Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 231100000481 chemical toxicant Toxicity 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 231100000026 common toxicity Toxicity 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000023011 digestive tract development Effects 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 235000011869 dried fruits Nutrition 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000030136 gastric emptying Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 235000015220 hamburgers Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 208000024798 heartburn Diseases 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 239000006049 herbal material Substances 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007413 intestinal health Effects 0.000 description 1
- 230000008944 intestinal immunity Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 150000002629 limonins Chemical class 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 230000002366 lipolytic effect Effects 0.000 description 1
- 238000013332 literature search Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- VDYCLYGKCGVBHN-UHFFFAOYSA-N pachymaic acid Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC(=C)C(C)C)C(O)=O)C(O)CC21C VDYCLYGKCGVBHN-UHFFFAOYSA-N 0.000 description 1
- SRDNLMOBFKJOSD-UHFFFAOYSA-N pachymic acid Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C(O)=O)C(O)CC21C SRDNLMOBFKJOSD-UHFFFAOYSA-N 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000000447 pesticide residue Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 230000036186 satiety Effects 0.000 description 1
- 235000019627 satiety Nutrition 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000019614 sour taste Nutrition 0.000 description 1
- 235000021259 spicy food Nutrition 0.000 description 1
- 208000018556 stomach disease Diseases 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 229960005559 sulforaphane Drugs 0.000 description 1
- 235000015487 sulforaphane Nutrition 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本申请属于医药技术领域，具体涉及一种改善肠道吸收、免疫功能的药食同源本草组合物。该由下列重量配比的原料药制成：蒲公英3～10份、山楂3～10份、鸡内金3～10份、麦芽3～10份、莱菔子3～10份、代代花2～6份、茯苓3～10份、罗汉果3～10份。药理实验结果表明：药食同源本草组合物对杯状细胞与上皮细胞的维持说明了它能有效改善肠道的吸收功能和免疫功能。
The application belongs to the technical field of medicine, and specifically relates to a medicinal and edible homologous herbal composition for improving intestinal absorption and immune function. The medicine is made from the following raw materials by weight: 3-10 parts of dandelion, 3-10 parts of hawthorn, 3-10 parts of Chine Neijin, 3-10 parts of malt, 3-10 parts of radish, and 2-10 parts of Daidaihua. 6 servings, 3-10 servings of Poria, and 3-10 servings of Luo Han Guo. The results of pharmacological experiments show that the maintenance of goblet cells and epithelial cells by the medicinal and edible homologous herbal composition indicates that it can effectively improve the absorption function and immune function of the intestinal tract.
Description
Technical Field
The application belongs to the technical field of medicines, and particularly relates to a medicinal and edible herbal composition for improving intestinal absorption and immune functions.
Background
The gastrointestinal health of modern people is influenced by irregular diet under high living pressure, unreasonable dietary structure caused by dependence on takeout and spicy and hot eating, bad living habits such as overnight overdrawing of bodies, abuse of broad-spectrum antibiotics, food intake containing complex additives, pollutants in the natural environment (contact of toxic chemical substances, pesticide residues in soil, and excessive particulate matters in the atmosphere), and the like.
The gastrointestinal diseases are the most common diseases at present, the total incidence rate accounts for about 20% of the population, and the theory of 'ten nine stomach diseases' is in China. If a person cares about maintaining his gastrointestinal health, the disease is averagely developed over 800 times in a lifetime, and the health cost is a small amount. Gastrointestinal health is important to both the physical health of individuals and the harmonious development of society.
Gastrointestinal health refers to the normal physiological functions of the gastrointestinal tract including digestion, absorption and secretion, and immune function. Traditional Chinese medicine pays attention to gastrointestinal health, and ancient people indicate that the spleen and the stomach are the acquired root. The food can be interpreted by modern scientific language as food intake, transportation and digestion of the gastrointestinal tract, nutrient absorption and waste excretion, and the food is subjected to a series of complex digestion and decomposition processes in the gastrointestinal tract to become small molecular substances which are absorbed by the intestinal tract and processed by the liver to become in-vivo substances for the utilization of the tissues of the whole body. Digestive breakdown of food ingredients in the gastrointestinal tract requires enzymatic reactions involving hydrolases secreted by the pancreas, gastrointestinal glands, bile secreted by the liver, and enterobacterial enzymes. 70-80% of the human immune system is distributed in or around the intestinal tract, and modern researches have proved that the microecology of the gastrointestinal tract plays an important role in regulating the immune system. The gastrointestinal tract is distributed with a large number of flora that constitute the micro-ecology of the gastrointestinal tract. The pre-cause of the dysfunction of the gastrointestinal tract is the disruption of the microecological balance of the gastrointestinal tract. The intestinal tract of a healthy human body is communicated with the outside, and a large number of microorganisms inhabit in the intestinal tract, the types and the numbers of which are relatively stable and balanced when the human body is in a healthy state, are called normal flora or home flora, are indispensable components in the internal environment of the body, and most of the normal flora or the home flora form a symbiotic relationship with the human body in a long-term co-evolution process. On one hand, the human body selectively allows certain microorganisms to be planted in the intestinal tract and provides a proper inhabitation environment for the microorganisms; on the other hand, the microorganisms and the metabolites thereof promote the perfection and influence of the intestinal mucosa immune function and participate in various metabolic functions of the human body. The microecological state of the human gastrointestinal tract can reflect the health state of the gastrointestinal tract function to a certain extent. Disturbances of gastrointestinal tract function are the main cause of gastrointestinal tract organ pathology.
The traditional Chinese medicine and the western medicine have respective treatment advantages in the aspects of regulating the gastrointestinal function and treating the gastrointestinal diseases. Modern medicine suffers from the drawback that it is only effective for certain symptoms of certain gastrointestinal disorders, for example, gastrointestinal discomfort in the face of helicobacter pylori infection is merely bactericidal. The traditional Chinese medicine treatment is usually determined according to syndrome differentiation and typing, has an overall treatment effect on improving the gastrointestinal tract function, and has the characteristics of pertinence, individuation and comprehensiveness. Especially, the traditional Chinese medicine treatment has the effect of relieving the gastrointestinal symptoms of modern medical stranded inadequacy. Taking functional dyspepsia which is common clinically and has no special treatment effect in modern medicine as an example, the traditional Chinese medicine divides the functional dyspepsia into a liver qi attacking stomach type, a diet stagnation type, a spleen and stomach weakness type, cold and heat mutual combination and a qi non-rising type, summarizes symptom signs as gastrointestinal motility dysfunction, choking gag on the upper part, distending pain in the stomach and a constipation on the lower part; if stomach qi does not descend or rise, belching, acid regurgitation, vomiting, heartburn, etc. can occur; spleen qi failing to ascend and descend causes sinking of middle qi, resulting in a sinking and distending stomach, a poor appetite and early fullness, and constipation. Through the methods of soothing liver, regulating qi, relieving stagnation and relieving stuffiness, promoting digestion, relieving stagnation, harmonizing stomach and lowering adverse qi, strengthening spleen, tonifying qi, harmonizing stomach and eliminating dampness.
Early basic prompts of the scientific research team indicate that gastrointestinal tract health is closely related to human immunity, and gastrointestinal tract flora disorder can cause susceptibility to upper respiratory tract infection. The upper respiratory tract infection is caused by virus and bacteria invading human body, and when virus and bacteria invade human body, the immune cells such as lymphocytes and macrophages of the human body are actively mobilized to resist and phagocytize the foreign invaders, so that the course of disease is shortened. 70-80% of the human immune system is distributed in or around the intestinal tract, and gastrointestinal dysfunction affects the systemic immunity. When the viruses exceed the killing ability of lymphocytes and macrophages, the body is invaded by viruses and bacteria. The occurrence of the recurrent respiratory tract infection is directly related to the immunity of the organism, the disease resistance of the body is not strong, and the body cannot resist external pathogenic bacteria, so the recurrent respiratory tract infection is easy to occur.
Through literature search and retrospective review, the traditional Chinese medicine means for treating gastrointestinal diseases has a plurality of schemes and means, and a plurality of classic formulas of the Chinese medicine means are not lacked. For example, Huoxiang Zhengqi pills, which are well known by common people, are commonly used for treating gastrointestinal diseases. The traditional Chinese medicine compositions are found to have certain unsafe factors, are still exemplified by the Huoxiang Zhengqi pills, and the common dosage form of the Huoxiang Zhengqi pills is Huoxiang Zhengqi liquid which contains 40 to 50 percent of alcohol and is not suitable for children and drivers. The pinellia ternate which is one of the components still has the problem of small toxicity after the dosage form improvement, and has challenges in clinical popularization and application and international trade barrier breakthrough. In addition, these classic traditional Chinese medicine compositions have pain spots which are caused by improper medication after being misused as OTC Chinese patent medicine. The traditional Chinese medicine composition has strong curative effect, namely, the traditional Chinese medicine composition has strong medicinal potency, and when the traditional Chinese medicine composition is used correctly, the effect is remarkable, and when the traditional Chinese medicine composition is not used properly, obvious side effects are easy to occur.
The invention solves the pain points and provides a medicinal and edible herbal composition. Consisting of a herbal material meeting the list of notifications about the management of further regulated health food materials (list of articles that are both food and drugs). Su Wen, Wu Chang Zheng Da Lun (plain questions and five often political affairs) considers that "the disease is treated by toxic pathogen, and six of them are removed; treating diseases with common toxicity, seven of them are removed; treating diseases with small toxicity, and removing eight of the medicines; no toxicity, ten remove nine; the cereal, meat, fruit and vegetable are eaten thoroughly. The Chinese medicament has high-efficiency and safe treatment advantages, is the basis of imported products (whether medicaments or food) and has huge development potential.
Disclosure of Invention
The invention aims to provide a medicinal and edible herbal composition for improving intestinal absorption and immune function. The composition can improve gastrointestinal tract function, maintain gastrointestinal tract health, and solve the problem of obvious side effect of the traditional Chinese medicine composition for improving gastrointestinal tract function.
A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight:
3-10 parts of dandelion, 3-10 parts of hawthorn, 3-10 parts of endothelium corneum gigeriae galli, 3-10 parts of malt, 3-10 parts of radish seed, 2-6 parts of seville orange flower, 3-10 parts of poria cocos and 3-10 parts of momordica grosvenori.
Preferably, the medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 5 parts of dandelion, 5 parts of hawthorn, 5 parts of endothelium corneum gigeriae galli, 5 parts of malt, 5 parts of radish seed, 3 parts of seville orange flower, 5 parts of poria cocos and 5 parts of momordica grosvenori.
Or, preferably, the medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 3 parts of dandelion, 3 parts of hawthorn, 3 parts of endothelium corneum gigeriae galli, 3 parts of malt, 3 parts of radish seed, 2 parts of seville orange flower, 3 parts of poria cocos and 3 parts of momordica grosvenori.
Or, preferably, the medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 10 parts of dandelion, 10 parts of hawthorn, 10 parts of endothelium corneum gigeriae galli, 10 parts of malt, 10 parts of radish seed, 6 parts of seville orange flower, 10 parts of poria cocos and 10 parts of momordica grosvenori.
Or, preferably, the medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 6 parts of dandelion, 6 parts of hawthorn, 6 parts of endothelium corneum gigeriae galli, 6 parts of malt, 6 parts of radish seed, 4 parts of seville orange flower, 6 parts of poria cocos and 6 parts of momordica grosvenori.
Or, preferably, the medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 9 parts of dandelion, 9 parts of hawthorn, 9 parts of endothelium corneum gigeriae galli, 9 parts of malt, 9 parts of radish seed, 6 parts of seville orange flower, 9 parts of poria cocos and 9 parts of momordica grosvenori.
The proportion of the weight proportion is obtained by scientific screening, and for special patients, such as severe or mild patients, obese patients or lean patients, the proportion of the components can be correspondingly adjusted, the increase or decrease is not more than 100 percent, and the drug effect is basically unchanged.
The weight parts of the above drugs, in g, are usually 1 dose.
The dosage form of the herbal composition is oral preparation. Preferably: decoction, extract, powder, Chinese medicinal granule, decoction, distillate, pill, powder, unguent, pellet, tablet, lozenge, colloid, yeast, dripping pill, soft capsule, superfine powder, and colloid. More preferably granules and decoctions.
When preparing the decoction, the method comprises the following steps: cleaning the above Chinese medicinal materials, soaking for one hour, decocting with water, boiling with strong fire, decocting with slow fire for half an hour, and removing residue. One dose is taken in the morning and at night. The composition is also suitable for infants. 1/6 for newborn children, 1/3-1/2 for infants, 2/3 for infants and toddlers, and 2/3 for children of school age.
The medicine and food homologous herbal and edible composition for improving intestinal absorption and immune function is applied to preparation of medicines for treating gastrointestinal heat accumulation syndrome, and symptoms of poor defecation habit caused by poor intestinal absorption, dyspepsia, abdominal distension and pain and the like caused by low immune function are shown.
In the medicinal and edible herbal composition for improving intestinal absorption and immune function, all medicaments are in a list of Chinese medicaments for both eating and medicament published by Weideng.
In the medicinal and edible herbal composition for improving intestinal absorption and immunologic function,
the herba Taraxaci is dried whole plant of Taraxacum mongolicum hand-held of Compositae, Taraxacum sinicum Kitag of Taraxacum sinicum or same genus. Bitter, sweet and cold; it enters liver and stomach meridians. Has the effects of clearing away heat and toxic materials, relieving swelling, dispersing pathogenic accumulation, inducing diuresis, and treating stranguria. The traditional Chinese medicine composition is mainly used for treating furuncle pyogenic infections, intestinal carbuncle, damp-heat jaundice, heat stranguria and pain and the like in clinic. Modern pharmacological research shows that the dandelion has wide biological activity and is mainly focused on the aspects of broad-spectrum bacteriostasis, tumor resistance, gastrointestinal tract function, liver protection, gallbladder benefiting, immunity, oxidation resistance and the like. Studies have confirmed that the dandelion aqueous extract has a stronger inhibitory effect on the activity of Escherichia coli (E. The dandelion polyphenol has certain bacteriostasis to staphylococcus aureus, bacillus subtilis, E.coli and salmonella, and the bacteriostasis to staphylococcus aureus and bacillus subtilis is especially obvious. Has obvious inhibition effect on gram-positive bacteria (staphylococcus aureus and bacillus subtilis).
Radish seed, the base source of which is the dried mature seed of radish Raphanus sativus L. Pungent, sweet and neutral in flavor; it enters lung, spleen and stomach meridians. Has effects of resolving food stagnation, relieving flatulence, lowering qi and eliminating phlegm. It is mainly used for treating diseases such as diet stagnation, abdominal pain and distention, constipation, stagnation and dysentery. Raphani semen contains Leluotaxane, and has metabolic enzyme inducing effect. The sulforaphane has obvious inhibition effect on staphylococcus and coliform bacillus. The radish seed aqueous extract has the pharmacological action of relaxing the pyloric sphincter of the stomach, quickly emptying the stomach and preventing food from being accumulated in the stomach.
The fructus crataegi is dried mature fruit of Crataegus Pinnatifida Bge of Rosaceae or Crataegus Pinnatifida Bge. Sour and sweet in taste, slightly warm in nature; it enters spleen, stomach and liver meridians. Has effects of resolving food stagnation, invigorating stomach, activating qi-flowing and removing blood stasis. It is mainly used for treating diseases such as meat food retention, gastric cavity fullness, dysentery, abdominal pain, hyperlipidemia, etc. The hawthorn contains lipolytic enzyme, can enhance the action of enzyme after entering stomach, promotes the digestion of meat, is beneficial to the conversion of cholesterol, and effectively solves dyspepsia. The hawthorn can promote the secretion of enzymes in gastric juice, promote digestion and relieve symptoms such as abdominal distension, pantothenic acid, abdominal pain, diarrhea and the like. The hawthorn is rich in pectin, and can promote gastrointestinal motility, thereby being helpful for relieving constipation symptoms.
Endothelium corneum Gigeriae Galli, the basal source is inner wall of dry sand sac of Gallus Gallus domesticus Brisson of Phasianidae. Sweet in taste and neutral in nature; it enters spleen, stomach, small intestine and bladder meridians. Has effects of invigorating stomach, resolving food stagnation, astringing essence and relieving enuresis. Is mainly used for treating indigestion, vomiting, diarrhea, infantile malnutrition and the like in clinic. The endothelium corneum Gigeriae Galli mainly contains gastric hormone, keratin, amino acids, etc., and has effects of increasing gastric secretion, improving gastrointestinal digestion, and accelerating gastric emptying rate.
Malt, the base source is mature fruit of Hordeum vulgare L. Sweet in taste and neutral in nature; it enters spleen and stomach meridians. Has effects of activating qi-flowing, resolving food stagnation, invigorating spleen, promoting appetite, removing milk and relieving flatulence. It is mainly used for treating indigestion, abdominal pain, spleen deficiency and anorexia. The malt contains isomaltose, and can regulate animal intestinal flora, raise antibody concentration and increase the number of immunocytes, so as to maintain gastrointestinal microecology and immunological function. The maltitol can reduce membrane lipid peroxidation, is a good free radical scavenger, and protects gastric mucosa.
The substitute flower is prepared from dried flower bud of Citrus aurantium of Rutaceae. Bitter and sour taste, slightly cold nature; it enters liver and spleen meridians. Has effects in promoting qi circulation, relieving epigastric distention, promoting digestion, eliminating phlegm, dispersing stagnated liver qi, regulating qi-flowing, regulating stomach function, and relieving vomit. Is mainly used for treating symptoms of chest and abdomen distress and distending pain, indigestion, phlegm and fluid retention, rectocele, discomfort in chest and hypochondrium, nausea and vomiting, poor appetite and the like in clinic. The seville orange flower contains polymethoxylated flavone, and has remarkable biological activity, including antivirus, antioxidation, anti-inflammatory, antitumor, antithrombotic, etc. The limonin compounds in the seville orange flower have the activities of scavenging free radicals and resisting cancers.
Poria cocos, the basic source is dried sclerotium of Wolf of Poria cos (Schw.) Wolf, a fungus of Polyporaceae. Sweet and light taste, mild in nature; it enters heart, lung, spleen and kidney meridians. Has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. It is mainly used for treating spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, etc. Poria contains pachyman, and has inhibitory effect on various bacteria. Can reduce gastric acid, and has prophylactic effect on digestive tract ulcer; has obvious protective effect on liver injury; has anti-tumor effect; can regulate immune function in various ways. Pachymic acid contained in Poria has effects of enhancing immunity, resisting tumor, tranquilizing mind, and lowering blood sugar.
Fructus Siraitiae Grosvenorii is dried fruit of Momoradica grosvenor Swingle of Cucurbitaceae. Sweet in taste and cool in nature; it enters lung and large intestine meridians. Has effects of clearing heat, moistening lung, and loosening bowel to relieve constipation. The traditional Chinese medicine composition is mainly used for treating constipation caused by intestinal dryness in clinic. The momordica grosvenori contains glucoside, has the effect of lubricating the intestines, contains a lot of dietary fibers, and has the effects of increasing satiety, promoting intestinal peristalsis and the like.
And (3) analysis of the formula and the prescription:
dandelion and momordica grosvenori for clearing heat and relaxing bowels;
radish seed, semen raphani, to promote digestion, relieve distension and descend qi;
endothelium corneum Gigeriae Galli, fructus crataegi, and fructus Hordei Germinatus-invigorating stomach, resolving food stagnation, and promoting qi circulation;
the bitter orange flower is used for promoting digestion, promoting qi circulation, regulating qi and harmonizing stomach.
The medicinal and edible herbal composition takes the dandelion and the radish seed as the monarch drugs, and clears away heat in the stomach and intestine; the chicken's gizzard-membrane, the hawthorn and the malt are used as ministerial drugs, the stomach is invigorated to supplement and transform the source, and the qi is promoted to eliminate food stagnation; the momordica grosvenori is an adjuvant, and the effects of moistening the intestines and relaxing the bowels of monarch drugs and ministerial drugs are enhanced; the seville orange flower can act as the qi of the whole body, and has the effects of dispelling stagnation, promoting digestion, strengthening spleen and descending qi.
The medicine and food homologous herbal composition is applicable to the symptoms of poor defecation habit caused by poor intestinal absorption, dyspepsia, abdominal distension and pain and the like caused by low immune function.
The intestinal tract is the largest digestive organ and toxin expelling organ of the human body and comprises five parts of small intestine, large intestine, anus, intestinal juice and intestinal flora. The intestinal tract has an absorption function, the small intestine is a nutrient absorber, and the large intestine has an absorption function on water liquid in food residues. The functional disorder of water absorption affects the peristalsis of intestines and stomach, and when the peristalsis of the intestines is weakened, food residues stay in the intestines for a long time, the water absorption is increased, and feces are dry, so that difficult or uncomfortable defecation can be caused. Once people see that the defecation is difficult or uncomfortable, the people are regarded as sub-health but not diseases, the defecation is often delayed and not cured, and chronic habitual constipation is formed, so that the defecation habit is not good after a long time. Pharmacological experimental research results show that after the medicinal and edible herbal composition is used for treatment, the rat intestinal tissue structure is clear, and epithelial cells are arranged in order. The intestinal epithelium is the part which can absorb nutrient and liquid to the maximum extent in the body, and the maintenance of the epithelial cells by the medicinal and edible herbal composition shows that the composition can effectively improve the absorption function of the intestinal tract. The feedback of pharmacological experiments shows that the constipation and other symptoms of children and adults can be effectively improved by taking the medicinal and edible herbal composition.
The intestinal tract is not only the main site for the digestion and absorption of nutrients, but also the congenital barrier for ensuring the homeostasis of the body. The important link forming the intestinal immunity is the immune barrier, the intestinal tract is the largest immune organ in vivo, the immunity of the intestinal tract is dragged to move the whole body, and the abnormal occurrence of the low immune function of the intestinal tract can cause the digestion and absorption function disorder of nutrient substances, dyspepsia, abdominal distension and pain, the enhancement of the susceptibility to pathogenic microorganisms and the like, thereby causing various diseases. Pharmacological experiment research results show that the normal group (N groups) has clear intestinal tissue structure and orderly arranged goblet cells; the intestinal tissue structure of the model group (group M) collapsed and goblet cells increased compared to the normal group; compared with the model group, the intestinal tissue of the medicinal and edible herbal composition group (KLB group) has compact structure and less goblet cell number. Goblet cell mucus secreting cells, which are closely related to glucose and amino acid uptake, are part of the mucosal barrier of the gut. The maintenance of goblet cells and epithelial cells by the medicinal and edible herbal composition indicates that the medicinal and edible herbal composition can effectively improve the immune function of intestinal tracts. Feedback of pharmacological experiments prompts that children and adults taking the medicinal and edible herbal composition can effectively improve symptoms such as dyspepsia, abdominal distension and pain.
The solid beverage prepared from the medicinal and edible herbal composition has good feedback on practical application, and takes an applicable questionnaire in Beijing area as an example. We find that the symptoms of constipation, fullness after eating and the like are improved after a user who has poor dietary habits drinks the traditional Chinese medicine granules prepared from the medicinal and edible herbal composition. The symptoms of diarrhea, oral ulcer, halitosis and the like are obviously reduced or eliminated after a person who experiences oily or spicy food takes the traditional Chinese medicine granules prepared from the medicinal and edible herbal composition to drink. The experients with fatness and poor self-induction intestinal peristalsis have regular stool, normal appetite and weight reduction tendency after taking the traditional Chinese medicine granules prepared from the medicinal and edible herbal composition.
The above medicinal materials are common foods, and have no toxicity and high safety. The medicinal and edible herbal composition has the effects of regulating intestinal flora, improving intestinal function and maintaining intestinal health. The medicinal and edible herbal composition has good regulating effect on gastrointestinal heat accumulation, poor eating habits and low immunity of children and children, has no heavy bitter taste, has sufficient natural fragrance of the herbal, and can be taken by children and children. Meanwhile, the medicinal and edible herbal composition is also suitable for people with healthy intestinal tracts, has comfortable mouthfeel and can be developed into natural herbal beverages, foods and the like.
The intestinal functions of infants and children are not completely developed, the digestive ability is weak, and in addition, the infants and children are rich in life and have a sense of pleasure, and the children often eat a large amount of hamburgers, fried chicken, chocolate, rice crust and other snacks which are easy to cause gastrointestinal heat accumulation, so that a large amount of infants and children have gastrointestinal heat accumulation symptoms, such as constipation, poor defecation habits, dyspepsia, abdominal distension and pain, halitosis, red tongue, uneasy sleep, easy cold and the like. Eating snacks breaks up normal three meals a day, frost is added on snow to gastrointestinal development, and vicious circle is involved. If parents do not select milk powder for infants, gastrointestinal heat accumulation of babies is also easily caused. Adverse environments such as air pollution also affect the gastrointestinal development of this generation of infants and children. The medicinal and edible herbal composition can treat and improve gastrointestinal heat accumulation symptoms, enhance intestinal functions of infants and children, assist intestinal development and improve autoimmunity of infants and children.
The composition can be made into decoction, extract, powder, Chinese medicinal granule, decoction, pill, powder, unguent, pellet, tablet, lozenge, colloid, yeast, dripping pill, soft capsule, superfine powder, colloid, injection, etc. The most common decoction is prepared by cleaning the traditional Chinese medicines, soaking for one hour, adding water for decocting, boiling over strong fire, decocting over slow fire for half an hour, and pouring out the filter residue. One dose is taken in the morning and at night. The composition is also suitable for infants. 1/6 for newborn children, 1/3-1/2 for infants, 2/3 for infants and toddlers, and 2/3 for children of school age.
Has the advantages that:
(1) the health-care food can achieve the effect of maintaining the health of the intestinal tract by adjusting the intestinal flora and improving the intestinal function, has the advantage of 'preventing the disease first', and maintains the health of the intestinal tract so as to improve the immunity of a human body.
(2) The pharmacological experiment result shows that: the maintenance of the medicinal and edible herbal composition on goblet cells and epithelial cells shows that the medicinal and edible herbal composition can effectively improve the absorption function and the immune function of intestinal tracts.
Drawings
FIG. 1 is a colon histopathological diagram of each group of SD rats. (Note: HE staining, 20X under the lens, scale: 50. mu. m.A: normal group (N); B: model group (M group); C: medicinal and edible herbal composition group (KLB group).)
Detailed Description
The present application will now be described more fully hereinafter with reference to the accompanying drawings, in which some embodiments of the invention are shown and described, but which are not intended to limit the invention thereto.
Laboratory instruments, reagents and materials used in the examples of the present invention are commercially available.
Example 1
A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight:
10 parts of dandelion, 10 parts of hawthorn, 10 parts of endothelium corneum gigeriae galli, 10 parts of malt, 10 parts of radish seed, 6 parts of seville orange flower, 10 parts of poria cocos and 10 parts of momordica grosvenori.
Example 2
A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight:
3 parts of dandelion, 3 parts of hawthorn, 3 parts of endothelium corneum gigeriae galli, 3 parts of malt, 3 parts of radish seed, 2 parts of seville orange flower, 3 parts of poria cocos and 3 parts of momordica grosvenori.
Example 3
A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight:
6 parts of dandelion, 6 parts of hawthorn, 6 parts of endothelium corneum gigeriae galli, 6 parts of malt, 6 parts of radish seed, 4 parts of seville orange flower, 6 parts of poria cocos and 6 parts of momordica grosvenori.
Example 4
A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight:
9 parts of dandelion, 9 parts of hawthorn, 9 parts of endothelium corneum gigeriae galli, 9 parts of malt, 9 parts of radish seed, 6 parts of seville orange flower, 9 parts of poria cocos and 9 parts of momordica grosvenori.
Example 5
A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight:
5 parts of dandelion, 5 parts of hawthorn, 5 parts of endothelium corneum gigeriae galli, 5 parts of malt, 5 parts of radish seed, 3 parts of seville orange flower, 5 parts of poria cocos and 5 parts of momordica grosvenori.
Example 6
A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight:
10g of dandelion, 10g of hawthorn, 10g of endothelium corneum gigeriae galli, 10g of malt, 10g of radish seed, 6g of seville orange flower, 10g of poria cocos and 10g of momordica grosvenori.
This is 1 dose.
The preparation method comprises the following steps: taking the traditional Chinese medicine formula granules according to the weight ratio to obtain the traditional Chinese medicine.
Example 7
A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight:
10g of dandelion, 10g of hawthorn, 10g of endothelium corneum gigeriae galli, 10g of malt, 10g of radish seed, 6g of seville orange flower, 10g of poria cocos and 10g of momordica grosvenori.
This is 1 dose.
The preparation method comprises the following steps: cleaning the above Chinese medicinal materials, soaking for one hour, decocting with water, boiling with strong fire, decocting with slow fire for half an hour, and removing residue. One dose is taken in the morning and at night.
Example 8
A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight:
5g of dandelion, 5g of hawthorn, 5g of endothelium corneum gigeriae galli, 5g of malt, 5g of radish seed, 3g of seville orange flower, 5g of poria cocos and 5g of momordica grosvenori.
This is 1 dose.
The preparation method comprises the following steps: taking the traditional Chinese medicine formula granules according to the weight ratio to obtain the traditional Chinese medicine.
Experimental example 1 pharmacological experiment of medicinal and edible herbal composition for improving intestinal absorption and immune function
SPF grade SD rats 30, male, 15-day-old, 40 ± 10g in weight, purchased from sbeff (beijing) biotechnology limited, license No.: SCXK [ Kn ] 2016-. The feed is raised in an animal house of the college of traditional Chinese medicine of Beijing university of traditional Chinese medicine, the environment is shielded, the temperature is 22-25 ℃, the humidity is 50-60%, water is freely fed, and the natural illumination is performed. The animal experimental protocol was approved by the animal research committee of the university of traditional Chinese medicine, Beijing in advance.
Normal group (N group) normal diet. The model group is fed with special high-heat feed and red star milk powder solution which are uniformly purchased, produced and controlled by the Schbefu (Beijing) biotechnology limited company for 6 days to form a gastrointestinal heat accumulation model. The medicinal and edible herbal composition group (KLB group) is used for intragastric gavage of the medicinal and edible herbal composition granular aqueous solution on the basis of molding.
Milk solution: dissolving red star whole sweet milk powder in pure water to prepare 52% milk solution, wherein the stomach filling amount is 1mL/100g each time, and the milk solution is taken once a day.
Medicinal and edible herbal composition granular water solution: the medicinal and edible herbal composition granules which are equivalent to 10 grams of clinical decoction pieces of dandelion, 10 grams of raw hawthorn, 10 grams of vinegar chicken's gizzard-membrane, 10 grams of malt, 10 grams of fried radish seed, 10 grams of poria cocos and 6 grams of daidai flower are purchased from Beijing kang rentang pharmaceutical industry Co., Ltd, and are non-additive full-ingredient traditional Chinese medicine formula granules. The Chinese medicinal granule is dissolved in pure water to prepare a solution with the concentration of 1.32g/ml twice a day.
Water was withheld on day 6 at night, blood was taken from the abdominal aorta after anesthesia on day 7 morning and colon tissue was collected and fixed in 10% formalin for at least 24h for further histopathological assessment, specifically 3cm above the cecum end. Rat intestinal tissue was fixed with sufficient 10% formalin for 24h, and tissue sections were prepared by material extraction, dehydration, wax immersion, embedding, sectioning, HE staining, and the like.
Experimental study results show that the normal group (N group) has clear intestinal tissue structure, and goblet cells and epithelial cells are arranged in order; the intestinal tissue structure of the model group (group M) collapsed and goblet cells increased compared to the normal group; compared with the model group, the intestine tissue of the medicinal and edible herbal composition group (KLB group) has compact structure and less goblet cell number, and the structure is shown in figure 1. Goblet cell mucus secreting cells, which are closely related to glucose and amino acid uptake, are part of the mucosal barrier of the gut. The intestinal epithelium is the site of maximum nutrient and fluid absorption within the body and must provide a tight barrier to prevent the invasion of pathogens. The maintenance of the medicinal and edible herbal composition on goblet cells and epithelial cells shows that the medicinal and edible herbal composition can effectively improve the absorption function and the immune function of intestinal tracts.
Claims (9)
1. A medicinal and edible herbal composition for improving intestinal absorption and immune function is characterized by being prepared from the following raw material medicines in parts by weight:
3-10 parts of dandelion, 3-10 parts of hawthorn, 3-10 parts of endothelium corneum gigeriae galli, 3-10 parts of malt, 3-10 parts of radish seed, 2-6 parts of seville orange flower, 3-10 parts of poria cocos and 3-10 parts of momordica grosvenori.
2. The medicinal and edible herbal composition for improving intestinal absorption and immune function according to claim 1, which is characterized by being prepared from the following raw material medicines in parts by weight:
5 parts of dandelion, 5 parts of hawthorn, 5 parts of endothelium corneum gigeriae galli, 5 parts of malt, 5 parts of radish seed, 3 parts of seville orange flower, 5 parts of poria cocos and 5 parts of momordica grosvenori.
3. The medicinal and edible herbal composition for improving intestinal absorption and immune function according to claim 1, which is characterized by being prepared from the following raw material medicines in parts by weight:
3 parts of dandelion, 3 parts of hawthorn, 3 parts of endothelium corneum gigeriae galli, 3 parts of malt, 3 parts of radish seed, 2 parts of seville orange flower, 3 parts of poria cocos and 3 parts of momordica grosvenori.
4. The medicinal and edible herbal composition for improving intestinal absorption and immune function according to claim 1, which is characterized by being prepared from the following raw material medicines in parts by weight:
10 parts of dandelion, 10 parts of hawthorn, 10 parts of endothelium corneum gigeriae galli, 10 parts of malt, 10 parts of radish seed, 6 parts of seville orange flower, 10 parts of poria cocos and 10 parts of momordica grosvenori.
5. The medicinal and edible herbal composition for improving intestinal absorption and immune function according to claim 1, which is characterized by being prepared from the following raw material medicines in parts by weight:
6 parts of dandelion, 6 parts of hawthorn, 6 parts of endothelium corneum gigeriae galli, 6 parts of malt, 6 parts of radish seed, 4 parts of seville orange flower, 6 parts of poria cocos and 6 parts of momordica grosvenori.
6. The medicinal and edible herbal composition for improving intestinal absorption and immune function according to claim 1, which is characterized by being prepared from the following raw material medicines in parts by weight:
9 parts of dandelion, 9 parts of hawthorn, 9 parts of endothelium corneum gigeriae galli, 9 parts of malt, 9 parts of radish seed, 6 parts of seville orange flower, 9 parts of poria cocos and 9 parts of momordica grosvenori.
7. The medicinal and edible herbal composition for improving intestinal absorption and immune function as claimed in claims 1-6, wherein the herbal composition is in the form of oral preparation or injection.
8. The herbal composition for improving intestinal absorption and immune function as defined in claims 1-6, wherein the herbal composition is in the form of decoction, extract, powder, Chinese medicinal granule, decoction, pill, powder, paste, pellet, tablet, lozenge, gum, yeast, drop pill, soft capsule, superfine powder, or colloid.
9. The use of the medicinal and edible herbal composition for improving intestinal absorption and immune function as claimed in claims 1-6 in the preparation of a medicament for treating gastrointestinal heat accumulation syndrome.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111176126.0A CN113769029B (en) | 2021-10-09 | 2021-10-09 | A medicine and food homologous herbal composition for improving intestinal absorption and immune function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111176126.0A CN113769029B (en) | 2021-10-09 | 2021-10-09 | A medicine and food homologous herbal composition for improving intestinal absorption and immune function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113769029A true CN113769029A (en) | 2021-12-10 |
| CN113769029B CN113769029B (en) | 2023-01-17 |
Family
ID=78854910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111176126.0A Active CN113769029B (en) | 2021-10-09 | 2021-10-09 | A medicine and food homologous herbal composition for improving intestinal absorption and immune function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113769029B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115463203A (en) * | 2022-10-08 | 2022-12-13 | 谷晓红 | A kind of traditional Chinese medicine composition for preventing influenza in children |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101589811A (en) * | 2009-03-18 | 2009-12-02 | 北京惠中铭捷生物科技有限公司 | A kind of nutraceutical and preparation method thereof with promotion digestive function |
| CN103689559A (en) * | 2012-09-28 | 2014-04-02 | 天津红日药业股份有限公司 | Health-preserving health food formula beneficial for improving gastrointestinal functions and preparation method thereof |
| CN110151934A (en) * | 2019-05-09 | 2019-08-23 | 高才胜 | A kind of drug and preparation method thereof for treating stomach trouble |
| CN112704722A (en) * | 2021-01-13 | 2021-04-27 | 山西中医药大学 | Health tea for promoting digestion and regulating stomach function and preparation method thereof |
-
2021
- 2021-10-09 CN CN202111176126.0A patent/CN113769029B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101589811A (en) * | 2009-03-18 | 2009-12-02 | 北京惠中铭捷生物科技有限公司 | A kind of nutraceutical and preparation method thereof with promotion digestive function |
| CN103689559A (en) * | 2012-09-28 | 2014-04-02 | 天津红日药业股份有限公司 | Health-preserving health food formula beneficial for improving gastrointestinal functions and preparation method thereof |
| CN110151934A (en) * | 2019-05-09 | 2019-08-23 | 高才胜 | A kind of drug and preparation method thereof for treating stomach trouble |
| CN112704722A (en) * | 2021-01-13 | 2021-04-27 | 山西中医药大学 | Health tea for promoting digestion and regulating stomach function and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 熊芹俊等: "从寒热虚实与气血阴阳浅析消食药临床应用", 《现代中医药》 * |
| 郝爱真等: "儿童开胃乐口服液促进儿童消化功能的临床研究", 《解放军医学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115463203A (en) * | 2022-10-08 | 2022-12-13 | 谷晓红 | A kind of traditional Chinese medicine composition for preventing influenza in children |
| CN115463203B (en) * | 2022-10-08 | 2023-11-07 | 谷晓红 | A kind of traditional Chinese medicine composition for preventing influenza in children |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113769029B (en) | 2023-01-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102048933B (en) | Chinese medicinal composition for treating infantile diarrhea and preparation method thereof | |
| CN101972338B (en) | Chinese medicinal preparation for treating infantile upper respiratory tract infection and preparation method thereof | |
| CN102198262B (en) | Chinese medicine preparation for treating infant rotavirus enteritis and preparation method thereof | |
| KR100373501B1 (en) | An antistress composition for a stress prevention and treatment | |
| CN104524110A (en) | Traditional Chinese medicine composition with functions of tonifying spleen and clearing damp | |
| CN103638372B (en) | A kind of Chinese medicine composition and its preparation method and application | |
| CN104643250A (en) | Solid beverage capable of bidirectionally regulating body weight and improving subhealth | |
| CN105362906A (en) | Traditional Chinese medicine for treating spleen-stomach deficiency and food stagnation symptoms of children and method for preparing traditional Chinese medicine | |
| CN103989955A (en) | Pharmaceutical composition for treating stomach and duodenum ulcer, superficial multiple gastric ulcer and erosive gastric ulcer | |
| CN105028995A (en) | Mixed dog food and preparation method thereof | |
| CN113769029A (en) | A medicinal and edible homologous herbal composition for improving intestinal absorption and immune function | |
| CN105770705A (en) | Medicinal preparation for treating functional dyspepsia of children and application of medicinal preparation | |
| CN106620474B (en) | Stomach-nourishing health-care medicine and preparation method thereof | |
| CN111264865A (en) | Thyroid nodule medical formula food and preparation method thereof | |
| CN115607629B (en) | A traditional Chinese medicine composition capable of protecting liver and relieving alcoholism and preparation method thereof | |
| CN104872642A (en) | Pancreatitis Non-Complete Nutritional Formula Food | |
| CN104352802A (en) | Traditional Chinese medicine composition for treating chronic dysentery and preparation method thereof | |
| CN104435744A (en) | Traditional Chinese medicine thick paste for treating functional dyspepsia and preparation method of traditional Chinese medicine thick paste | |
| CN103877484A (en) | Traditional Chinese medicine oral liquid for treating oral liquid | |
| CN1453004A (en) | Cathartic medicine and its prepn | |
| CN103720808A (en) | Composition with constipation relieving function and application and preparation method thereof | |
| CN103211988B (en) | Pharmaceutical composition for treating porcine infectious gastrointestinal inflammations | |
| JP2010100576A (en) | Constipation-improving agent | |
| CN101229331B (en) | Medicine for treating anorexia, limosis and preparing method thereof | |
| CN108404068B (en) | Pharmaceutical composition for treating and/or preventing diarrhea and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20221226 Address after: 100029, No. 11 East Third Ring Road, Chaoyang District, Beijing Applicant after: BEIJING University OF CHINESE MEDICINE Address before: 100029 Beijing University of Chinese Medicine, 11 North Third Ring Road, Beijing, Chaoyang District Applicant before: Gu Xiaohong Applicant before: BEIJING University OF CHINESE MEDICINE |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20211210 Assignee: Zhiqi health industry (Shandong) Group Co.,Ltd. Assignor: BEIJING University OF CHINESE MEDICINE Contract record no.: X2023990000340 Denomination of invention: A medicinal and edible homologous herbal composition for improving intestinal absorption and immune function Granted publication date: 20230117 License type: Exclusive License Record date: 20230323 |