CN104096159B - Alleviate viable bacteria mixture of chronic dysentery and bowel dysfunction and preparation method thereof - Google Patents

Alleviate viable bacteria mixture of chronic dysentery and bowel dysfunction and preparation method thereof Download PDF

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CN104096159B
CN104096159B CN201410343777.8A CN201410343777A CN104096159B CN 104096159 B CN104096159 B CN 104096159B CN 201410343777 A CN201410343777 A CN 201410343777A CN 104096159 B CN104096159 B CN 104096159B
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parts
preparation
viable bacteria
bowel dysfunction
chronic dysentery
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CN104096159A (en
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姜大磊
钮自宇
张鸣鸣
高玉强
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Qingdao Municipal Hospital
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Abstract

The invention discloses a kind of viable bacteria mixture for alleviating chronic dysentery and bowel dysfunction, the primary raw material for taking following weight proportions is prepared from：24 parts of evodia rutaecarpa, 3 10 parts of cape jasmine builds bent 4 12 parts, 5 12 parts of the fruit of Chinese magnoliavine, 4 12 parts of fushen, 6 15 parts of hawthorn, 69 parts of the stem of noble dendrobium, 5 12 parts of fructus amomi, 3 10 parts of rhizoma nelumbinis, 0.3 1.0 parts of bacillus cereus.Selected materials of the present invention are traditional Chinese medicine, have no side effect, and medicine source is easy to get, and medicinal material is with low cost, are made on the basis of it have studied lot of documents, pharmacology work and clinical test, have good curative effect to alleviating chronic dysentery and bowel dysfunction.

Description

Alleviate viable bacteria mixture of chronic dysentery and bowel dysfunction and preparation method thereof
Technical field
The present invention relates to traditional Chinese medicine field, more particularly to alleviate chronic dysentery and bowel dysfunction viable bacteria mixture and Its preparation method.
Background technology
Lasting delay or recurrent exerbation were not more chronic bacillary dysentery more than 2 months in the acute bacillary dysentery course of disease.. Chronic bacillary dysentery is mostly because acute stages treated is improper, or nutritious bad, rickets, intestinal parasitic disease and usually The many reasons such as the health that is not careful in one's diet are caused.Often appear as atypical dysentery symptom, stomachache, diarrhoea, abdominal distension etc..When receiving The raw and cold food of cool or feed, can cause acute attack, now can suffer from diarrhoea, suffer from abdominal pain and draw pus and blood stool.When it is good when it is bad, although treatment, Effect is not also good, protracted course of disease.Up to more than 5 years, diarrhoea or was alternately present recurrent exerbation medical history with constipation, and general diarrhoea is daily No more than 3-5 times, stool in the pasty state, with a small amount of mucus and bloody stool, there is rancid, is often accompanied by navel week or lower abdominal pain.Have a medical check-up When in the accessible colon for thickening of Right Lower Abdomen.Symptom is sustainable or interval, and the intermittent phase is different in size, often because it is tired, improper diet, Eat and drink immoderately and the inducement as recurrence such as emotional change.Because long-term function of intestinal canal is disorderly, patient often has different degrees of disappearing Thin, anaemia, hypovitaminosis, hepatomegaly, neurasthenia etc..In addition, mostly forming localized abscesses after chronic enterobrosis.Chronic cases Easily there is appendicitis, hepatapostema, also because of intestinal mucosa hyperplasia, granuloma occurs and abdominal mass is formed, pole is like tumour, referred to as Ah meter Bar knurl, easy mistaken diagnosis is intestinal cancer, is more common in caecum, sigmoid colon and rectum.
Gut flora, such as microflora of human body intestinal canal, Bifidobacterium Bifidum, Bacillus acidi lactici etc. can synthesize various growth in humans Develop necessary vitamin, such as B family vitamin（Vitamin B1, B2, B6, B12）, vitamin K, nicotinic acid, pantothenic acid etc., moreover it is possible to utilize Protein residue synthesizes nonessential amino acid, such as asparagus fern door propylhomoserin, alanine, valine and threonine, and participate in carbohydrate and The metabolism of protein, while the absorption of the mineral elements such as iron, magnesium, zinc can also be promoted.In microorganism in human body intestinal canal, exceed 99% is all bacterium, quantity of surviving about 100,000,000, there is 500-1000 different species.The bacterium of these huge numbers Three major classes can be substantially divided into：Beneficial bacterium, harmful bacteria and neutral bacterium.Human body whether health with enteron aisle in beneficial flora structure It is closely bound up.Gut flora in long-term evolutionary process, by individual adaptation and natural selection, in flora variety classes it Between, between flora and host, between flora, host and environment, all the time in dynamic balance state, formation one is mutually interdependent Deposit, mutually the system of restriction, therefore, human body under normal circumstances, stablize relatively, host is shown as not pathogenic by Bacterial community. There is research to point out, the ratio of beneficial bacterium reaches 70% in physically strong people's enteron aisle, and ordinary people is then 25%, and constipation crowd be reduced to 15%, and the ratio of the probiotics in cancer patient enteron aisle only has 10%.Live away from home miscellaneous micro- in the intestines and stomach of Healthy People Biology, these microorganisms are referred to as gut flora.Bacterium in human gi-tract may make up that one huge and the ecosystem of complexity System, people's colon just has the strain of more than 400.The bacterium overwhelming majority for entering stomach from oral cavity is killed by hydrochloric acid in gastric juice, is left Mainly gram-positive aerobic bacteria.The composition of small intestinal flora is between stomach and colon.In the flora and stomach of proximal small bowel It is close, but can often isolate Escherichia coli and anaerobic bacteria.In distal section ileum, between anaerobism.The flora of proximal small bowel and phase in stomach Closely, Escherichia coli and anaerobic bacteria but can often be isolated.Distal section ileum, the quantity of anaerobic bacteria begins to exceed aerobic bacteria, wherein large intestine The constant presence of bacillus, anaerobic bacteria such as Bacteroides, Bifidobacterium, Clostridium, there is a great deal of.In ileocaecal sphineter Distally, bacterial concentration steeply rises, and colon bacteria almost accounts for excrement at concentrations up to 10.11-10.12 CFU/ml, bacteria total amount The 1/3 of dry weight.Wherein anaerobic bacteria includes the gut flora that we often say up to the 10.3-10.4 enteric microorganism of aerobic bacteria, and Virus and eucaryote etc..Gut flora is it is now recognized that kind times about more than 2000, main bacteria seed is bacillus faecalis category, double qi bars Pseudomonas and Eubacterium.It is mainly big including Firmicutes, bacteroid, actinomyces, mycetozoan four than more than the cell number of human body Class.Human microbial's bacterium colony engineering research shows that each individual gut flora is different, has the single-minded of oneself as fingerprint Property, the similitude of twinborn micropopulation nearly 50% illustrates that the genotype of host plays main work in the composition of gut flora With human flora stablizes relatively once setting up, and diet, medicine are to change its principal element for constituting.Research display feed Fat high, sugar high, high-protein diet just can significantly modify gut flora within one day.It is main crowd with high fat diet, bacteroid accounts for enteron aisle Advantage, and high carbohydrate meals person, enteron aisle mycetozoan are dominant.Influence of the antibiotic to gut flora is most important, has A little even to can be described as destructive, some bacterium colony several months are difficult to recover after antibiotic application, and some species can be reduced for a long time, Even disappear.At present, it is found that many diseases are relevant with the change of gut flora, such as anaphylactia, autoimmune disease, fertilizer Fat, diabetes, Crohn disease etc..Crohn disease is that immunity of organism tissue is not proper to enteric microorganism under environmental factor effect When reaction caused by chronic sustained inflammatory reaction.Enteric microorganism plays vital in the morbidity of Crohn disease Effect, the animal under germ-free condition will not occur the inflammation of enteron aisle.The gut flora of research display Crohn disease people is different from just Ordinary person group, wherein there is tumor susceptibility gene, also plays the role of diet and drug factors, and had research display Crow grace The capsule that patient took or swallowed normal relatives' excrement making by stomach tube Specified-within-the-article can treat Crohn disease.In a word, enteric microorganism with Our healthy, disease are closely related.
At present, alleviate chronic dysentery and the Chinese medicine of bowel dysfunction is more rare, regarding to the issue above, publication number The Chinese patent literature of 103405703A (application number 201310275325.6) discloses a kind of traditional Chinese medicine pill for treating chronic dysentery And preparation method thereof,：The traditional Chinese medicine pill of the treatment chronic dysentery constitutes Chinese medicinal component by following weight ratio：Root of large-flowered skullcap 10-15 parts, in vain Art 12-18 parts, 15 parts of Poria cocos, 5 parts of Divine Comedy, 8 parts of the banksia rose, fructus amomi 10-15 parts, 8 parts of cuttlebone, 10 parts of sophora flower, 5 parts of balloonflower root, 20 parts of tree-of-heaven skin, garden burnet 10-15 parts, 20 parts of purslane, 6 parts of Radix Glycyrrhizae.Publication number CN103520428A（Application number 201310516102.4）Chinese patent literature disclose it is a kind of with improve bowel dysfunction Chinese medicine composition and its should With being characterized in by mass fraction by 10-30 parts of rhizoma atractylodis macrocephalae, 10-30 parts of stir-baked RADIX PAEONIAE ALBA, 10-30 parts of Flos Albiziae, 6-15 parts of stewing Pueraria lobota Root, 6-15 portion of Buddha's hand, 6-15 portions of charred FRUCTUS CRATAEGI, 15-30 portions of Chinese yam, the 6-15 portions of fruit of Chinese magnoliavine are made.Publication number CN103142882A （Application number 201310050193.7）Chinese patent disclose a kind of medicine for treating gastrointestinal dysfunction and its preparation side Method,：It is made up of the bulk drug in following weight range：15-30 grams of purslane, 15-30 grams of coix seed, 25-35 grams of Chinese yam, 10-20 grams of French beans, 10-20 grams of Gorgon fruit, 3-6 grams of lotus leaf.
In a word, traditional Chinese medicine also relative shortcoming in terms of chronic dysentery and bowel dysfunction is alleviated, there is also a series of asking Topic, needs further raising.
The content of the invention
In view of the shortcomings of the prior art, prepared it is an object of the invention to provide one kind simple, convenient to take, portable Alleviate the viable bacteria mixture of chronic dysentery and bowel dysfunction.Another object of the present invention is just to provide the preparation of above-mentioned viable bacteria mixture Method.
Above-mentioned purpose of the invention is achieved through the following technical solutions：
Alleviate the viable bacteria mixture of chronic dysentery and bowel dysfunction, the primary raw material for taking following weight proportions is prepared from： Evodia rutaecarpa 2-4 parts, cape jasmine 3-10 parts, build bent 4-12 parts, fruit of Chinese magnoliavine 5-12 parts, fushen 4-12 parts, hawthorn 6-15 parts, stem of noble dendrobium 6-9 Part, fructus amomi 5-12 parts, rhizoma nelumbinis 3-10 parts, bacillus cereus 0.3-1.0 parts（Preferably, 0.5-0.8 parts, it is preferred that 0.6 Part）.
Alleviate the viable bacteria mixture of chronic dysentery and bowel dysfunction, preferred scheme is take following weight proportions main Raw material is prepared from：Evodia rutaecarpa 2.5-3.5 parts, cape jasmine 5-8 parts, build bent 7-9 parts, fruit of Chinese magnoliavine 7-10 parts, fushen 7-9 parts, hawthorn 9-12 parts, stem of noble dendrobium 7-8 parts, fructus amomi 7-10 parts, rhizoma nelumbinis 5-8 parts, bacillus cereus 0.5-0.8 parts.
Alleviate the viable bacteria mixture of chronic dysentery and bowel dysfunction, more preferred scheme is to take following weight proportions Primary raw material is prepared from：3 parts of evodia rutaecarpa, 7 parts of cape jasmine builds bent 8 parts, 8 parts of the fruit of Chinese magnoliavine, 8 parts of fushen, 11 parts of hawthorn, the stem of noble dendrobium 8 Part, 9 parts of fructus amomi, 7 parts of rhizoma nelumbinis, 0.6 part of bacillus cereus.
Present invention also offers the preparation that above-mentioned viable bacteria mixture is made pharmaceutically acceptable oral liquid, pulvis or capsule Method.
The preparation method of the viable bacteria mixture oral liquid for alleviating chronic dysentery and bowel dysfunction is：
（1）Cape jasmine, the fruit of Chinese magnoliavine, fructus amomi and rhizoma nelumbinis are placed in marmite, are fried to 5 sixty percent ripe, be ground into fine powder, cross 80-120 Mesh sieve（It is preferred that 90-110 mesh sieves, more preferred 100 mesh sieve）；
（2）Evodia rutaecarpa is placed in marmite, is added water, moderate heat is decocted 40-60 minutes（It is preferred that 45-55 minutes, more preferred 50 Minute）；
（3）Song, fushen, hawthorn, the stem of noble dendrobium and step will be built（1）Gains are placed in step（2）Marmite in, add water, intense fire It is fried open, is cooked by slow fire 20-40 minutes（It is preferred that 25-35 minutes, more preferred 30 minutes）；
（4）Treat that temperature is cooled to 20 DEG C -45 DEG C（It is preferred that 25 DEG C -40 DEG C, more preferred 35 DEG C）When, add waxy brood cell's bar Bacterium and sucrose, stand 1-3 hours（It is preferred that 1.5-2.5 hours, more preferred 2 hours）, filter, filtrate is obtained, cool down, it is concentrated into original The 1/2 of solution, sterile packaged.
The preparation method of above-mentioned viable bacteria mixture oral liquid, it is characterized in that：Step（4）Dosage of sucrose is step（3）Gained medicine The 3%-5% of liquid（It is preferred that 3.5%-4.5%, more preferred 4%）.
Instructions of taking：10ml is each taken, it is daily 2-3 times, with 35 DEG C or so of warm boiled water, 3 days courses for the treatment of.
The preparation method of the viable bacteria mixture pulvis for alleviating chronic dysentery and bowel dysfunction is：
（1）Cape jasmine, the fruit of Chinese magnoliavine, fructus amomi and rhizoma nelumbinis are ground into fine powder, 40-80 mesh sieves are crossed（It is preferred that 50-70 mesh sieves, more excellent Select 60 mesh sieves）, after mixing, it is put into glass container, extracted 2 times, first time 2-4 hours with 6 times of amount alcohol refluxs（It is preferred that 2.5- 3.5 hours, more preferred 3 hours）, second 1-2 hours（It is preferred that 1.2-1.8 hours, more preferred 1.5 hours）, merging carries Liquid is taken, liquid and the dregs of a decoction are obtained respectively；
（2）Evodia rutaecarpa is placed in marmite, step is added（1）Gained liquid, moderate heat is decocted 40-60 minutes（It is preferred that 45-55 Minute, more preferred 50 minutes）；
（3）Song, fushen, hawthorn, the stem of noble dendrobium will be built and be placed in step（2）Marmite in, add water, intense fire is fried open, and is cooked by slow fire 20- 40 minutes（It is preferred that 25-35 minutes, more preferred 30 minutes）；
（4）When temperature is cooled to 20 DEG C -45 DEG C, Bacillus cereus and sucrose are added, stand 1-3 hours（It is preferred that 1.5-2.5 hours, more preferred 2 hours）, filter, filtrate is obtained, add step（1）The gained dregs of a decoction, cooling, are condensed into thick paste（45 ℃）, the then scattered softwood of light pressure is modulated into, cross 80-120 mesh sieves（It is preferred that 90-110 mesh sieves, more preferred 100 mesh sieve）, drying, powder It is broken, obtain final product pulvis.
The preparation method of above-mentioned viable bacteria mixture pulvis, it is characterized in that：Step（4）Treat that temperature is cooled down（It is preferred that 25 DEG C -40 DEG C, More preferred 35 DEG C）.
The preparation method of above-mentioned viable bacteria mixture pulvis, it is characterized in that：Step（4）It is 1.2-1.4's to be concentrated to give relative density Thick paste（It is preferred that 1.25-1.35, more preferred 1.3）.
Application method：Every time with 35 DEG C or so of warm boiled water, 5g/ times, daily 2-3 times, 3 days courses for the treatment of.
The preparation method of the viable bacteria mixture capsule for alleviating chronic dysentery and bowel dysfunction is：
（1）Cape jasmine, the fruit of Chinese magnoliavine, fructus amomi and rhizoma nelumbinis are ground into fine powder, 40-80 mesh sieves are crossed（It is preferred that 50-70 mesh sieves, more excellent Select 60 mesh sieves）, after mixing, it is put into glass container, extracted 2 times, first time 2-4 hours with 6 times of amount alcohol refluxs（It is preferred that 2.5- 3.5 hours, more preferred 3 hours）, second 1-2 hours（It is preferred that 1.2-1.8 hours, more preferred 1.5 hours）, merging carries Liquid is taken, liquid and the dregs of a decoction are obtained respectively；
（2）Evodia rutaecarpa is placed in marmite, step is added（1）Gained liquid, moderate heat is decocted 40-60 minutes（It is preferred that 45-55 Minute, more preferred 50 minutes）；
（3）Song, fushen, hawthorn, the stem of noble dendrobium will be built and be placed in step（2）Marmite in, add water, intense fire is fried open, and is cooked by slow fire 20- 40 minutes（It is preferred that 25-35 minutes, more preferred 30 minutes）；
（4）When temperature is cooled to 20 DEG C -45 DEG C, Bacillus cereus and sucrose are added, stand 1-3 hours（It is preferred that 1.5-2.5 hours, more preferred 2 hours）, filter, filtrate is obtained, add step（1）The gained dregs of a decoction, cooling, are condensed into thick paste（45 ℃）, the then scattered softwood of light pressure is modulated into, cross 80-120 mesh sieves（It is preferred that 90-110 mesh sieves, more preferred 100 mesh sieve）, dry, press According to 0.4-0.6g/（It is preferred that 0.45-0.55g/, it is more preferred 0.5g/）Metering, adds according to the preparation for processing of capsule Work is into capsule formulation.
The preparation method of above-mentioned viable bacteria mixture capsule, it is characterized in that：Step（4）Treat that temperature is cooled down（It is preferred that 25 DEG C -40 DEG C, More preferred 35 DEG C）.
The preparation method of above-mentioned viable bacteria mixture capsule, it is characterized in that：Step（4）It is 1.2-1.4's to be concentrated to give relative density Thick paste（It is preferred that 1.25-1.35, more preferred 1.3）.
Instructions of taking：Three times a day, it is each 3-5, with 35 DEG C or so of warm boiled water, 3 days courses for the treatment of.
The pharmacology of main Chinese medicine material used of the invention is as follows：
Evodia rutaecarpa：It is the dry mature fruit of luxuriant growth savoury herb evodia rutaecarpa, stone tiger or thin hair evodia rutaecarpa.Taste is pungent, hardship, property Heat, it is slightly poisonous.Return liver, spleen, stomach, kidney channel.With eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI, effect of supporing yang antidiarrheal.For fainting male bitterly, Cold hernia stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, abdominal distention vomits acid regurgitation, Diarrhoea；Control aphtha, hypertension outward.
Cape jasmine：It is the dry mature fruit of madder wort cape jasmine.Bitter, it is cold in nature.The thoughts of returning home, lung, tri-jiao channel.With purging intense heat Relieving restlessness, reducing fever and causing diuresis, effect of removing pattogenic heat from the blood and toxic material from the body.For Vexed, yellow subcutaneous ulcer urinates red, blood strangury and dry pain, and blood-head tells nosebleed, hot eyes swells Bitterly, pathogenic fire,toxin and furuncles；Control bruise pain outward.
Build song：Bitter, it is warm in nature.There is reinforcing spleen to promote digestion, qi-regulating dampness elimination, inducing diaphoresis.For fever and chills headache, food stagnation resistance In, vomit turgor, cold, summertime heatstroke, cold heating, have a headache bodily pain, vomiting and diarrhoea, indigestion, abdominal distension uncomfortable in chest.
The fruit of Chinese magnoliavine：It is the dry mature fruit of magnoliaceae schisandra.It is sour, sweet, it is warm in nature.Return lung, the heart, kidney channel.Tool There are astringent or styptic treatment for spontaneous sweating, the nourishing generate fluid of convergence, effect of kidney calming.Breathed heavily for void of coughing long, emission, enuresis frequent micturition, endless diarrhea, from Sweat, night sweat, injury thirst, feeble pulse of losing heart, Heat Diabetes, palpitation and insomnia.
Fushen：It is the Chinese herbal product of plant Poria cocos, former plant multiparasitization is on masson pine or Duan Mu.It is sweet, light, it is mild-natured. There is excreting dampness, invigorating the spleen, calming heart.For calming heart, calm the nerves, Li Shui, palpitation with fear of having a guilty conscience, forgetful, insomnia, frightened epilepsy, difficult urination.
Hawthorn：It is sour, sweet, slightly warm in nature.Returns spleen, stomach, Liver Channel.With food digesting stomach fortifying, effect of scattered stasis.For meat It is stagnant, gastral cavilty turgor, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, confidant sting, hernia pain, hyperlipidemia.Charred FRUCTUS CRATAEGI disappears Food leads stagnant effect enhancing, and for meat stagnation, rush down dysentery is not well.
The stem of noble dendrobium：It is sweet, cold nature.It is new for the dry measure used in former times of orchid gold and silver five, iron sheet building stones or stem of Eyeshaped Dendrobium and its allied species It is fresh or dry stem.Return stomach, kidney channel.With reinforcing stomach reg fluid, effect of nourishing Yin and clearing heat.For impairment of yin body fluid deficiency, dry polydipsia, deficiency of food is done Vomit, after being ill abnormal heat, mesh is secretly failed to understand.
Fructus amomi：Taste is pungent, it is warm in nature.Return board, stomach, kidney channel.It is the drying and ripening of zingiberaceous plant amomum viosum, green shell sand or SEMEN AMOMI LONGILIGULA Fruit.It is warming spleen and stopping diarrha with dampness elimination appetizing, effect of regulating the flow of vital energy antiabortive.For turbi damp obstructing in middle-JIAO, gastral cavity ruffian is not hungry, deficiency-cold in spleen and stomach, vomiting Diarrhea, pernicious vomiting, fetal irritability.
Rhizoma nelumbinis：It is sweet, puckery, it is mild-natured.Return liver, lung, stomach.It is the dry root stipes portion of nymphaeaceae plant lotus.With hemostasis, Effect of dispersing blood stasis, for spitting blood, spitting of blood, bleeding from five sense organs or subcutaneous tissue, hematuria, uterine bleeding.
Bacillus cereus：It is the one kind in bacillus.20-45 DEG C of growth temperature range, less than 10 DEG C growths are slow Slowly or do not grow.It is present in soil, water, air and animal intestinal tract etc..After Bacillus cereus enters enteron aisle, to grape ball The growth of bacterium has Inhibiting and protective function, and to Bifidobacterium Bifidum, Bacillus acidi lactici, the growth of the human body beneficial bacterium such as peptostreptococcus has Facilitation, the excessive oxygen in consumption enteron aisle, creates anaerobic environment, promotes the growth of anaerobic bacteria, adjusts intestinal bacilli illness, Improve micro-ecological environment, reach the purpose for being suitable to beneficial anaerobic bacteria existence, suppressing harmful aerobic bacteria.Bacillus cercus can be produced Antibacterial material, suppresses harmful microbe breeding, and the nutritional ingredient in degraded soil is improved the ecological environment.Bacterium egg can be produced White enzyme, can be used for retting, be the measure bacterium of various antibiotic antibacterial activities.For suffering from diarrhoea, bowel dysfunction and enteritis controls Treat.
Technical advantage of the invention is mainly reflected in：
1. medicament of the present invention is based on the principle of traditional Chinese medical herbal treatment, is that have studied lot of documents, pharmacology work and clinic It is made on the basis of experiment, effect is significant.
2. this medicament selected materials are traditional Chinese medicine, have no side effect.
3. medicinal material medicine source is easy to get, with low cost, will not bring big financial burden to patient.
Specific embodiment
Technical scheme, but protection domain not limited to this are described in detail with reference to embodiment and experimental example.It is real Apply it is raw materials used in example be all commercially available, such as build bent purchased from Meishan Di Kang Chinese medicines Co., Ltd, specification is every piece of weight 10g, every piece heavy 20g, every piece of weight 30g has.Cape jasmine is purchased from purchased from Bozhou Chinese medicine trade center.
Embodiment 1 alleviates the viable bacteria mixture of chronic dysentery and bowel dysfunction, takes the primary raw material system of following weight proportions It is standby to form（Every part takes 20g）：4 parts of evodia rutaecarpa, 10 parts of cape jasmine builds bent 12 parts, 12 parts of the fruit of Chinese magnoliavine, 12 parts of fushen, 15 parts of hawthorn, stone 9 parts of dry measure used in former times, 12 parts of fructus amomi, 10 parts of rhizoma nelumbinis, 1.0 parts of bacillus cereus.
The preparation method of the viable bacteria mixture oral liquid of above-mentioned alleviation chronic dysentery and bowel dysfunction is：
（1）Cape jasmine, the fruit of Chinese magnoliavine, fructus amomi and rhizoma nelumbinis are placed in marmite, are fried to 5 sixty percent ripe, be ground into fine powder, cross 100 mesh Sieve；
（2）Evodia rutaecarpa is placed in marmite, is added water, moderate heat is decocted 50 minutes；
（3）Song, fushen, hawthorn, the stem of noble dendrobium and step will be built（1）Gains are placed in step（2）Marmite in, add water, intense fire It is fried open, is cooked by slow fire 30 minutes；
（4）When temperature is cooled to 35 DEG C, Bacillus cereus and sucrose are added, stand 2 hours, filtering obtains filtrate, cold But, the 1/2 of original solution, sterile packaged are concentrated into.
The instructions of taking of oral liquid of the present invention：10ml is each taken, it is daily 2-3 times, with 35 DEG C or so of warm boiled water, 3 days courses for the treatment of.
The old XX of model case one, female, 38 years old, Shandong Province Weifang people from Shouguang City.Long-term dysentery, often eats some stop dysentery Product, simply starts effect good every time, and is readily formed dependence, is all to start to eat like a bird, and later amount is more next Bigger, effect is not felt any better but, as long as one cuts out, again can dysentery again, for a long time, again and again, the situation of dysentery Do not improve not only, also feel increasingly severe, most obvious performance is exactly to cause digestive system function to get muddled, and causes battalion Support bad, on the face color spot long, pachylosis is lackluster.
Later, household had heard the viable bacteria mixture of alleviation chronic dysentery of the invention and bowel dysfunction, took the institute of embodiment 1 The viable bacteria mixture oral liquid of chronic dysentery and bowel dysfunction must be alleviated after 2 days, dysentery is just substantially improved, suffered from abdominal pain also obvious Alleviated.Take 3 times daily, taking on an empty stomach, adhere to that the gained of embodiment 1 alleviates chronic dysentery and bowel dysfunction After 5 days, the symptom of dysentery has substantially disappeared viable bacteria mixture oral liquid.Take the gained of embodiment 1 and alleviate chronic dysentery and intestines The viable bacteria mixture oral liquid of dysfunction is after 6 days, is changed to daily 1-2 times, gets up take once in the morning, evening sleep before take one It is secondary, adhere to 10 days, absorption of the stomach to food is improved, also improve underfed situation, Mrs's Chen complexion of today Also become fine.
Embodiment 2 alleviates the viable bacteria mixture of chronic dysentery and bowel dysfunction, takes the primary raw material system of following weight proportions It is standby to form（Every part takes 20g）：3.5 parts of evodia rutaecarpa, 8 parts of cape jasmine builds bent 9 parts, 10 parts of the fruit of Chinese magnoliavine, 9 parts of fushen, 12 parts of hawthorn, stone 8 parts of dry measure used in former times, 10 parts of fructus amomi, 8 parts of rhizoma nelumbinis, 0.8 part of bacillus cereus.
The preparation method of the viable bacteria mixture pulvis of above-mentioned alleviation chronic dysentery and bowel dysfunction is：
（1）Cape jasmine, the fruit of Chinese magnoliavine, fructus amomi and rhizoma nelumbinis are ground into fine powder, 60 mesh sieves are crossed, after mixing, is put into glass container, used Measure alcohol refluxs for 6 times to extract 2 times, 3 hours for the first time, second 1.5 hours, merge extract solution, liquid and the dregs of a decoction are obtained respectively；
（2）Evodia rutaecarpa is placed in marmite, step is added（1）Gained liquid, moderate heat is decocted 50 minutes；
（3）Song, fushen, hawthorn, the stem of noble dendrobium will be built and be placed in step（2）Marmite in, add water, intense fire is fried open, and is cooked by slow fire 30 Minute；
（4）When temperature is cooled to 35 DEG C, Bacillus cereus and sucrose are added, stand 2 hours, filtering obtains filtrate, plus Enter step（1）The gained dregs of a decoction, cooling, are condensed into thick paste（45℃）, the then scattered softwood of light pressure is modulated into, 100 mesh sieves are crossed, dry, Crush, obtain final product pulvis.
The instructions of taking of pulvis of the present invention：Each take 5g/ bags, it is daily 2-3 times, with 35 DEG C or so of warm boiled water, 3 Its course for the treatment of.
The grandson XX of model case two, man, 36 years old, Zibo City of Shandong Province Huantai people.Toil away irregular plus diet, Lee Mr. can usually feel stomachache, and until 2011, the symptom of cramp occurred in Mr. Li, and he is considered not having a meal carefully usually Cause, oneself is sought medical advice and medicine.When incipient, really stomachache phenomenon mitigated, but eaten a period of time after, just not Take effect greatly, or even have also appeared serious dysentery, Mr. Li is very worried to this.He starts to recognize that the disease of oneself may not have It is so simple in the imagination.Eat after some medicines, the dysentery phenomenon of Mr. Li has certain improvement, and he does not just rethink treatment Thing.But unexpectedly, soon occur dysentery again, and situation is very serious, finally goes to hospital to be checked, finds The mucous membrane of colon of Mr. Li is damaged very serious, and after hospitalize for a period of time, symptom is eased, can be soon There is dysentery in another.
On August 16th, 2012, when Mr. Li feels hopeless, it is not intended to which pleasant to the ear friend describes alleviation chronic dysentery and intestines work( The disorderly viable bacteria mixture of energy.Taking the gained of embodiment 2 and alleviating the viable bacteria mixture pulvis 3 days of chronic dysentery and bowel dysfunction Afterwards, stomachache, the phenomenon of dysentery have obtained obvious improvement, continue to take the gained of embodiment 2 alleviation chronic dysentery and gut function is disorderly Random viable bacteria mixture pulvis removes examination in hospital after 3 days, it is found that mucous membrane of colon breakage has disappeared, and 2 are nowadays pass by soon , there is not stomachache, the situation of dysentery yet in Nian Liao, and health has been recovered completely.
Embodiment 3 alleviates the viable bacteria mixture of chronic dysentery and bowel dysfunction, takes the primary raw material system of following weight proportions It is standby to form（Every part takes 30g）：3 parts of evodia rutaecarpa, 7 parts of cape jasmine builds bent 8 parts, 8 parts of the fruit of Chinese magnoliavine, 8 parts of fushen, 11 parts of hawthorn, the stem of noble dendrobium 8 Part, 9 parts of fructus amomi, 7 parts of rhizoma nelumbinis, 0.6 part of bacillus cereus.
The preparation method of the viable bacteria mixture capsule of above-mentioned alleviation chronic dysentery and bowel dysfunction is：
（1）Cape jasmine, the fruit of Chinese magnoliavine, fructus amomi and rhizoma nelumbinis are ground into fine powder, 60 mesh sieves are crossed, after mixing, is put into glass container, used Measure alcohol refluxs for 6 times to extract 2 times, 3 hours for the first time, second 1.5 hours, merge extract solution, liquid and the dregs of a decoction are obtained respectively；
（2）Evodia rutaecarpa is placed in marmite, step is added（1）Gained liquid, moderate heat is decocted 50 minutes；
（3）Song, fushen, hawthorn, the stem of noble dendrobium will be built and be placed in step（2）Marmite in, add water, intense fire is fried open, and is cooked by slow fire 30 Minute；
（4）When temperature is cooled to 35 DEG C, Bacillus cereus and sucrose are added, stand 2 hours, filtering obtains filtrate, plus Enter step（1）The gained dregs of a decoction, cooling, are condensed into thick paste（45℃）, the then scattered softwood of light pressure is modulated into, 100 mesh sieves are crossed, dry, According to 0.5g/ metering, capsule formulation is processed into according to the preparation for processing of capsule.
The instructions of taking of capsule of the present invention：Three times a day, it is each 3-5, with 35 DEG C or so of warm boiled water, 3 days one The course for the treatment of.
The gained of test example embodiment 3 alleviates the clinical practice of the viable bacteria mixture capsule of chronic dysentery and bowel dysfunction： 2 months -2012 years 2 months 2010,200 patients, wherein women 100, male 100 are screened.2 weeks before experiment, to this Crowd carries out Continuous Observation, records symptom and change, is randomly divided into two groups, experimental group and control group, and experimental group takes embodiment 3 Gained alleviates the viable bacteria mixture capsule of chronic dysentery and bowel dysfunction, and control group takes other medicines（Norfloxacin）.Use Method is：Experimental group, before meals half an hour take, three times a day, each 3-5,3 days courses for the treatment of；Control group, before meals half an hour Take, 3 times a day, 2 tablets once.Curative effect situation criterion:Cure:Malaise symptoms disappear completely after after 3 courses for the treatment of of drug administration Lose, energy and muscle power are remarkably reinforced；Effectively：Malaise symptoms mitigate or partial disappearance, energy and muscle power after 3 courses for the treatment of of drug administration Enhancing；It is invalid：Malaise symptoms are unchanged or the later stage recurs after 3 courses for the treatment of of drug administration.Wherein, total effective rate include cure rate and It is efficient.Result is as shown in table 1.
Table 1
Therapeutic effect：As it can be seen from table 1 taking the viable bacteria mixture glue that the present invention alleviates chronic dysentery and bowel dysfunction The cure rate of capsule is up to 78%, and total effective rate 98%, inefficiency is only 2%；And take the cure rate only 31% of Norfloxacin, it is total effectively Rate 86%, inefficiency is up to 14%.It can be seen that：Take the viable bacteria mixture capsule that the present invention alleviates chronic dysentery and bowel dysfunction Effect be substantially better than and take Norfloxacin.
Table 2
As can be seen from Table 2：Take the viable bacteria mixture capsule 3 days that the present invention alleviates chronic dysentery and bowel dysfunction, 52% Patient above feels to have taken a turn for the better, and malaise symptoms are improved；Take the present invention and alleviate chronic dysentery and bowel dysfunction Viable bacteria mixture capsule 6 days, more than 74% patient feels to have taken a turn for the better, and malaise symptoms improve or disappear, spirit, muscle power enhancing；Clothes Alleviate the viable bacteria mixture capsule 9 days of chronic dysentery and bowel dysfunction with the present invention, more than 92% patient feels to have taken a turn for the better, Appetite is remarkably reinforced, and malaise symptoms improve or disappear, spirit, muscle power enhancing, and some patientss self-induction is without malaise symptoms.It can be seen that Take the present invention alleviate chronic dysentery and bowel dysfunction viable bacteria mixture capsule experimental group effect apparently higher than oral west The control group of medicine Norfloxacin.
It should be pointed out that specific embodiment is the more representational example of the present invention, it is clear that skill of the invention Art scheme is not limited to above-described embodiment, can also there is many variations.One of ordinary skill in the art, it is clearly public with institute of the invention What written description open or according to file was undoubtedly obtained, it is considered as this patent scope of the claimed.

Claims (9)

1. the preparation method of the viable bacteria mixture of chronic dysentery and bowel dysfunction is alleviated, it is characterised in that take following weight proportions Raw material：3 parts of evodia rutaecarpa, 7 parts of cape jasmine builds bent 8 parts, 8 parts of the fruit of Chinese magnoliavine, 8 parts of fushen, 11 parts of hawthorn, 8 parts of the stem of noble dendrobium, 9 parts of fructus amomi, 7 parts of rhizoma nelumbinis, 0.6 part of bacillus cereus；Pharmaceutically acceptable capsule is made, step is：
（1）Cape jasmine, the fruit of Chinese magnoliavine, fructus amomi and rhizoma nelumbinis are ground into fine powder, 60 mesh sieves are crossed, after mixing, is put into glass container, with 6 times Amount alcohol reflux extract 2 times, first time 2.5-3.5 hour, second 1.2-1.8 hour, merge extract solution, respectively obtain liquid with The dregs of a decoction；
（2）Evodia rutaecarpa is placed in marmite, step is added（1）Gained liquid, moderate heat is decocted 45-55 minutes；
（3）Song, fushen, hawthorn, the stem of noble dendrobium will be built and be placed in step（2）Marmite in, intense fire is fried open, and is cooked by slow fire 25-35 minutes；
（4）When temperature is cooled to 35 DEG C, Bacillus cereus and sucrose are added, stand 2 hours, filtering obtains filtrate, adds step Suddenly（1）The gained dregs of a decoction, cooling is condensed into the thick paste that relative density is 1.2-1.4, is modulated into the then scattered softwood of light pressure, crosses 90- 110 mesh sieves, drying, according to 0.45-0.55g/ metering, capsule formulation is processed into according to the preparation for processing of capsule.
2. preparation method according to claim 1, it is characterized in that：Step（1）3 hours for the first time.
3. preparation method according to claim 1, it is characterized in that：Step（1）Second 1.5 hours.
4. preparation method according to claim 1, it is characterized in that：Step（2）Moderate heat is decocted 50 minutes.
5. preparation method according to claim 1, it is characterized in that：Step（3）It is cooked by slow fire 30 minutes.
6. preparation method according to claim 1, it is characterized in that：Step（4）It is 1.25-1.35's to be condensed into relative density Thick paste.
7. preparation method according to claim 6, it is characterized in that：Step（4）It is condensed into the thick paste that relative density is 1.3.
8. preparation method according to claim 1, it is characterized in that：Step（4）Cross 100 mesh sieves.
9. preparation method according to claim 1, it is characterized in that：Step（4）According to 0.5g/ metering.
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