CN104096159A - Viable bacteria mixture for relieving chronic dysentery and bowel dysfunction and preparation method thereof - Google Patents

Viable bacteria mixture for relieving chronic dysentery and bowel dysfunction and preparation method thereof Download PDF

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CN104096159A
CN104096159A CN201410343777.8A CN201410343777A CN104096159A CN 104096159 A CN104096159 A CN 104096159A CN 201410343777 A CN201410343777 A CN 201410343777A CN 104096159 A CN104096159 A CN 104096159A
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fructus
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CN104096159B (en
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李庆彦
刘晶晶
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Qingdao Municipal Hospital
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王健芳
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Abstract

The invention discloses a viable bacteria mixture for relieving chronic dysentery and bowel dysfunction. The mixture is prepared by main raw materials in parts by weight as follows: 2-4 parts of fructus evodiae, 3-10 parts of fructus gardenia, 4-12 parts of jianqu, 5-12 parts of fructus schisandra chinensis, 4-12 parts of root poria, 6-15 parts of hawthorns, 6-9 parts of dendrobium, 5-12 parts of fructus amomi, 3-10 parts of rhizoma nelumbinis and 0.3-1.0 part of bacillus cereus. According to viable bacteria mixture for relieving chronic dysentery and bowel dysfunction, selected materials are traditional Chinese medical materials and do not have any side effect, further, the medical material resources are easy to obtain, the medical material cost is low, and the viable bacteria mixture is prepared on the basis of a large quantity of research of literatures, pharmacological work and clinic trials and has a good curative effect on relieving of chronic dysentery and bowel dysfunction.

Description

Viable bacteria mixture of relieve chronic dysentery and bowel dysfunction and preparation method thereof
Technical field
The present invention relates to Chinese medicine field, particularly relate to viable bacteria mixture of relieve chronic dysentery and bowel dysfunction and preparation method thereof.
Background technology
In the acute bacillary dysentery course of disease, lasting delay or the period of greater than two months that repeatedly shows effect are not more chronic bacillary dysentery.。Chronic bacillary dysentery is because acute stages treated is improper mostly, or nutritious bad, rickets, intestinal parasitic disease and the many reasons such as health that are not usually careful in one's diet cause.Usually show as atypical dysentery symptom, stomachache, diarrhoea, abdominal distention etc.When suffering from cold or take food raw and cold food, can cause acute attack, now can suffer from diarrhoea, suffer from abdominal pain and draw bloody purulent stool.Bad when fashion, although treatment, effect is not good yet, protracted course of disease.Medical history can reach more than 5 years, and diarrhoea outbreak or alternately occur with constipation repeatedly, generally suffers from diarrhoea and be no more than 3-5 time every day, stool in the pasty state, with mucus and hemafecia on a small quantity, have rancid, often with umbilicus week or lower abdominal pain.While having a medical check-up, can touch in Right Lower Abdomen the colon thickening.Symptom is sustainable or intermittently, the intermission is different in size, often becomes the inducement of recurrence because of fatigue, improper diet, eating and drinking too much at one meal and emotion changes etc.Because of long-term function of intestinal canal disorder, patient Chang You becoming thin in various degree, anemia, vitamin deficiency, hepatomegaly, neurasthenia etc.In addition, after chronic intestinal perforation, mostly form local abscess.Easily there is appendicitis, liver abscess in chronic case, also because of intestinal mucosa hypertrophy, granuloma and form abdominal mass occurs, and the utmost point, like tumor, is called ameboma, and easily mistaken diagnosis is intestinal cancer, is more common in caecum, sigmoid colon and rectum.
Intestinal microbial population, the normal microorganism of human body intestinal canal, as bifidus bacillus, lactobacillus etc. can synthesize various human bulk-growth and grow necessary vitamin, as vitamin B group (vitamin B1, B2, B6, B12), vitamin K, nicotinic acid, pantothenic acid etc., can also utilize protein residue to synthesize non essential amino acid, as Radix Asparagi door propylhomoserin, alanine, valine and threonine etc., and participate in the metabolism of saccharide and protein, can also promote the absorption of the mineral elements such as ferrum, magnesium, zinc simultaneously.In microorganism in human body intestinal canal, exceeding 99% is all antibacterial, and nearly 100,000,000 of the quantity of surviving has 500-1000 different kind.The huge antibacterial of these numbers roughly can be divided into three large classes: probiotics, harmful bacteria and neutral bacterium.Whether health is closely bound up with the beneficial flora structure in intestinal for human body.Intestinal microbial population is in long-term evolutionary process, by individual adaptation and natural selection, in flora between variety classes, between flora and host, between flora, host and environment, all the time in dynamic balance state, form one and depend on each other for existence, mutually the system of restriction, therefore, under normal circumstances, flora structure is relatively stable for human body, host is shown as not pathogenic.Have research to point out, in physically strong people's intestinal, the ratio of probiotics reaches 70%, and ordinary people is 25%, and constipation crowd reduces to 15%, and the ratio of probiotic bacteria in cancer patient intestinal only has 10%.Miscellaneous microorganism of living away from home in the gastrointestinal tract of Healthy People, these microorganisms are called intestinal microbial population.Antibacterial in human gi-tract can form a huge and complicated ecosystem, and people's colonic just has 400 above strains.The antibacterial overwhelming majority who enters stomach from oral cavity is killed by gastric acid, and remaining is mainly Gram-positive aerobe.The formation of little intestinal flora is between harmonization of the stomach colon.Flora and the gastric of proximal small bowel are close, but often can isolate escherichia coli and anaerobe.At section ileum far away, between anaerobism.Flora and the gastric of proximal small bowel are close, but often can isolate escherichia coli and anaerobe.Section ileum far away, the quantity of anaerobe starts to exceed aerobe, the wherein constant existence of escherichia coli, anaerobe, as Bacteroides, Bifidobacterium, Clostridium, has a great deal of.In the distally of ileocecal valve, bacterial concentration sharply rises, and colon bacteria concentration is up to 10.11-10.12 CFU/ml, and bacteria total amount almost accounts for 1/3 of feces dry weight.The 10.3-10.4 enteric microorganism that wherein anaerobe reaches aerobe comprises the intestinal microbial population that our often say, and viral and eukaryote etc.Intestinal microbial population is thought nearly kind more than 2000 doubly at present, and main bacteria seed is bacillus faecalis genus, Bifidobacterium and Eubacterium.More than the cell number of human body, mainly comprise Firmicutes, bacteroid, actinomycetes, the large class of mycetozoan four.The engineering research of mankind's microbe colony shows the intestinal microbial population difference of each individuality, as fingerprint, there is the specificity of oneself, the similarity of twinborn micropopulation nearly 50%, the genotype that host is described is brought into play Main Function in the formation of intestinal microbial population, once it is just relatively stable that human body flora is set up, and diet, medicine are the principal elements that changes its formation.Studies show that feed one day high fat, high sugar, high protein diet just can obviously change intestinal microbial population.Taking high fat diet as owner group, intestinal bacteroid is preponderated, and high carbohydrate meals person, intestinal mycetozoan is preponderated.Antibiotic is most important on the impact of intestinal microbial population, and some even can be described as destructive, and after antibiotic application, some bacterium colony several months is difficult to recover, and some kind can reduce for a long time, even disappears.At present, find that numerous disease is relevant with the change of intestinal microbial population, as anaphylactic disease, autoimmune disease, obesity, diabetes, Crohn disease etc.Crohn disease is under environmental factors effect, the inflammatory reaction of the chronic sustained that immunity of organism tissue causes the inappropriate reaction of enteric microorganism.Enteric microorganism plays vital effect in the morbidity of Crohn disease, and the inflammation of intestinal can not occur the animal under aseptic condition.The intestinal microbial population that studies show that Crohn disease people is different from normal population, wherein there is the effect of tumor susceptibility gene, also there is the effect of diet and medicine factor, and had and studies show that the capsule that Crohn disease people takes by stomach tube Specified-within-the-article or the normal relatives' feces swallowed is made can treat Crohn disease.In a word, enteric microorganism and we healthy, disease is closely related.
At present, the Chinese medicine of relieve chronic dysentery and bowel dysfunction is comparatively rare, for the problems referred to above, the Chinese patent literature of publication number 103405703A (application number 201310275325.6) discloses a kind of Chinese medicine pill for the treatment of chronic dysentery and preparation method thereof, : the Chinese medicine pill of described treatment chronic dysentery forms Chinese medicine component by following weight ratio: Radix Scutellariae 10-15 part, Rhizoma Atractylodis Macrocephalae 12-18 part, 15 parts, Poria, 5 parts of Massa Medicata Fermentata, 8 parts of the Radix Aucklandiae, Fructus Amomi 10-15 part, 8 parts of Endoconcha Sepiaes, 10 parts, Flos Sophorae, 5 parts of Radix Platycodoniss, 20 parts of ailanthus altissima (mill.) swingle skins, Radix Sanguisorbae 10-15 part, 20 parts of Herba Portulacaes, 6 parts, Radix Glycyrrhizae.Publication number CN103520428A(application number 201310516102.4) Chinese patent literature a kind of the have Chinese medicine composition and the application thereof that improve bowel dysfunction are disclosed, be characterized in being made by 10-30 part Rhizoma Atractylodis Macrocephalae (parched), 10-30 part Radix Paeoniae Alba (parched), 10-30 part Flos Albiziae, 6-15 part roasted RADIX PUERARIAE, 6-15 part Fructus Citri Sarcodactylis, 6-15 part Fructus Crataegi (parched to brown), 15-30 part Rhizoma Dioscoreae, 6-15 part Fructus Schisandrae Chinensis by mass fraction.Publication number CN103142882A(application number 201310050193.7) Chinese patent a kind of medicine for the treatment of gastrointestinal dysfunction and preparation method thereof is disclosed,: it is to be made up of the crude drug in following weight range: Herba Portulacae 15-30 gram, Semen Coicis 15-30 gram, Rhizoma Dioscoreae 25-35 gram, Seem Lablab Album 10-20 gram, Semen Euryales 10-20 gram, Folium Nelumbinis 3-6 gram.
In a word, Chinese medicine is also relatively short of aspect relieve chronic dysentery and bowel dysfunction, also has a series of problem, needs further to be improved.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of viable bacteria mixture of preparing simple, taking convenience, portable relieve chronic dysentery and bowel dysfunction.Another object of the present invention is just to provide the preparation method of above-mentioned viable bacteria mixture.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The viable bacteria mixture of relieve chronic dysentery and bowel dysfunction, takes off the primary raw material of stating weight proportion and is prepared from: Fructus Evodiae 2-4 part, Fructus Gardeniae 3-10 part, Massa Medicata Fermentata 4-12 part, Fructus Schisandrae Chinensis 5-12 part, Poria cum Radix Pini 4-12 part, Fructus Crataegi 6-15 part, Herba Dendrobii 6-9 part, Fructus Amomi 5-12 part, Nodus Nelumbinis Rhizomatis 3-10 part, bacillus cereus 0.3-1.0 part is (preferred, 0.5-0.8 part, preferred, 0.6 part).
The viable bacteria mixture of relieve chronic dysentery and bowel dysfunction, preferred scheme is, takes off the primary raw material of stating weight proportion and is prepared from: Fructus Evodiae 2.5-3.5 part, Fructus Gardeniae 5-8 part, Massa Medicata Fermentata 7-9 part, Fructus Schisandrae Chinensis 7-10 part, Poria cum Radix Pini 7-9 part, Fructus Crataegi 9-12 part, Herba Dendrobii 7-8 part, Fructus Amomi 7-10 part, Nodus Nelumbinis Rhizomatis 5-8 part, bacillus cereus 0.5-0.8 part.
The viable bacteria mixture of relieve chronic dysentery and bowel dysfunction, the scheme being more preferably is, takes off the primary raw material of stating weight proportion and is prepared from :3 parts of Fructus Evodiaes, 7 parts of Fructus Gardeniaes, 8 parts of Massa Medicata Fermentata, 8 parts of Fructus Schisandrae Chinensis, 8 parts of Poria cum Radix Pinis, 11 parts of Fructus Crataegis, 8 parts of Herba Dendrobiis, 9 parts of Fructus Amomis, 7 parts of Nodus Nelumbinis Rhizomatis, 0.6 part of bacillus cereus.
The present invention also provides the preparation method of above-mentioned viable bacteria mixture being made to pharmaceutically acceptable oral liquid, powder or capsule.
The preparation method of the viable bacteria mixture oral liquid of described relieve chronic dysentery and bowel dysfunction is:
(1) Fructus Gardeniae, Fructus Schisandrae Chinensis, Fructus Amomi and Nodus Nelumbinis Rhizomatis are placed in to marmite, fry to 5 sixty percent ripe, be ground into fine powder, cross 80-120 mesh sieve (preferably 90-110 mesh sieve, is more preferably 100 mesh sieves);
(2) Fructus Evodiae is placed in to marmite, adds water, moderate heat decocts 40-60 minute (preferably 45-55 minute, is more preferably 50 minutes);
(3) Massa Medicata Fermentata, Poria cum Radix Pini, Fructus Crataegi, Herba Dendrobii and step (1) gains are placed in to the marmite of step (2), add water, intense fire is fried open, slow fire boiling 20-40 minute (preferably 25-35 minute, is more preferably 30 minutes);
(4) while treating that temperature is cooled to 20 DEG C-45 DEG C (preferably 25 DEG C-40 DEG C, be more preferably 35 DEG C), add Bacillus cereus and sucrose, standing 1-3 hour (preferably 1.5-2.5 hour, be more preferably 2 hours), filter, obtain filtrate, cooling, be concentrated into 1/2 of original solution, sterile packaged.
The preparation method of above-mentioned viable bacteria mixture oral liquid, is characterized in that: step (4) dosage of sucrose is the preferred 3.5%-4.5% of 3%-5%(of step (3) gained medicinal liquid, is more preferably 4%).
Instructions of taking: each serving using 10ml, every day 2-3 time, with the warm boiled water of 35 DEG C of left and right, 3 days courses for the treatment of.
The preparation method of the viable bacteria mixture powder of described relieve chronic dysentery and bowel dysfunction is:
(1) Fructus Gardeniae, Fructus Schisandrae Chinensis, Fructus Amomi and Nodus Nelumbinis Rhizomatis are ground into fine powder, cross 40-80 mesh sieve (preferably 50-70 mesh sieve, is more preferably 60 mesh sieves), after mixing, put into glass container, with 6 times of amount alcohol reflux 2 times, 2-4 hour for the first time (preferably 2.5-3.5 hour, is more preferably 3 hours), 1-2 hour for the second time (preferably 1.2-1.8 hour, be more preferably 1.5 hours), merge extractive liquid,, obtains respectively medicinal liquid and medicinal residues;
(2) Fructus Evodiae is placed in to marmite, adds step (1) gained medicinal liquid, moderate heat decocts 40-60 minute (preferably 45-55 minute, is more preferably 50 minutes);
(3) Massa Medicata Fermentata, Poria cum Radix Pini, Fructus Crataegi, Herba Dendrobii are placed in to the marmite of step (2), add water, intense fire is fried open, slow fire boiling 20-40 minute (preferably 25-35 minute, is more preferably 30 minutes);
(4) in the time that temperature is cooled to 20 DEG C-45 DEG C, add Bacillus cereus and sucrose, standing 1-3 hour (preferably 1.5-2.5 hour, be more preferably 2 hours), filter, obtain filtrate, add step (1) gained medicinal residues, cooling, be condensed into thick paste (45 DEG C), be modulated into the soft material that light pressure is fallen apart, cross 80-120 mesh sieve (preferably 90-110 mesh sieve, is more preferably 100 mesh sieves), dry, pulverize, obtain powder.
The preparation method of above-mentioned viable bacteria mixture powder, is characterized in that: step (4) is treated temperature cooling (preferably 25 DEG C-40 DEG C, be more preferably 35 DEG C).
The preparation method of above-mentioned viable bacteria mixture powder, is characterized in that: step (4) concentrated the relative density thick paste (preferably 1.25-1.35, is more preferably 1.3) that is 1.2-1.4.
Using method: use the warm boiled water of 35 DEG C of left and right at every turn, 5g/ time, every day 2-3 time, 3 days courses for the treatment of.
The preparation method of the viable bacteria mixture capsule of described relieve chronic dysentery and bowel dysfunction is:
(1) Fructus Gardeniae, Fructus Schisandrae Chinensis, Fructus Amomi and Nodus Nelumbinis Rhizomatis are ground into fine powder, cross 40-80 mesh sieve (preferably 50-70 mesh sieve, is more preferably 60 mesh sieves), after mixing, put into glass container, with 6 times of amount alcohol reflux 2 times, 2-4 hour for the first time (preferably 2.5-3.5 hour, is more preferably 3 hours), 1-2 hour for the second time (preferably 1.2-1.8 hour, be more preferably 1.5 hours), merge extractive liquid,, obtains respectively medicinal liquid and medicinal residues;
(2) Fructus Evodiae is placed in to marmite, adds step (1) gained medicinal liquid, moderate heat decocts 40-60 minute (preferably 45-55 minute, is more preferably 50 minutes);
(3) Massa Medicata Fermentata, Poria cum Radix Pini, Fructus Crataegi, Herba Dendrobii are placed in to the marmite of step (2), add water, intense fire is fried open, slow fire boiling 20-40 minute (preferably 25-35 minute, is more preferably 30 minutes);
(4) in the time that temperature is cooled to 20 DEG C-45 DEG C, add Bacillus cereus and sucrose, standing 1-3 hour (preferably 1.5-2.5 hour, be more preferably 2 hours), filter, obtain filtrate, add step (1) gained medicinal residues, cooling, be condensed into thick paste (45 DEG C), be modulated into the soft material that light pressure is fallen apart, cross 80-120 mesh sieve (preferably 90-110 mesh sieve, is more preferably 100 mesh sieves), dry, according to 0.4-0.6g/ grain (preferably 0.45-0.55g/ grain, is more preferably 0.5g/ grain) metering, be processed into capsule formulation according to the preparation for processing of capsule.
The preparation method of above-mentioned viable bacteria mixture capsule, is characterized in that: step (4) is treated temperature cooling (preferably 25 DEG C-40 DEG C, be more preferably 35 DEG C).
The preparation method of above-mentioned viable bacteria mixture capsule, is characterized in that: step (4) concentrated the relative density thick paste (preferably 1.25-1.35, is more preferably 1.3) that is 1.2-1.4.
Instructions of taking: every day 3 times, each 3-5 grain, with the warm boiled water of 35 DEG C of left and right, 3 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Evodiae: be the dry mature fruit of luxuriant growth savoury herb Fructus Evodiae, stone tiger or thin hair Fructus Evodiae.Acrid in the mouth, hardship, hot in nature, slightly poisonous.Return liver, spleen, stomach, kidney channel.There is dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, effect of supporing yang antidiarrheal.The sun that is used for fainting is had a headache, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea; External treatment aphtha, hypertension.
Fructus Gardeniae: be the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae.Bitter in the mouth, cold in nature.GUIXIN, lung, tri-jiao channel.There is pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, effect of removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, yellow cellulitis dark coloured urine, blood strangury and dry pain, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Massa Medicata Fermentata: bitter in the mouth, warm in nature.The effect of there is strengthening the spleen to promote digestion, regulating QI to expel dampness, inducing sweat.For cold and heat headache, in dyspepsia resistance, vomiting distension, Common Cold, summertime heatstroke, the heating of being afraid of cold, headache general pain, vomiting and diarrhoea, dyspepsia, abdominal distention uncomfortable in chest.
Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra.Sour in the mouth, sweet, warm in nature.Return lung, the heart, kidney channel.There is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Poria cum Radix Pini: be the Chinese medicine product of plant Poria, former plant multiparasitization is on Pinus massoniana Lamb or Duan Mu.Sweet in the mouth, light, property is flat.There is effect of eliminating dampness by diuresis, spleen invigorating, mind calming.For mind calming, calm the nerves, diuretic, the palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.There is promoting digestion and invigorating the stomach, effect of circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens, and for meat stagnation, dysentery is not well.
Herba Dendrobii: sweet in the mouth, cold nature.For the fresh or dry stem of orchid gold silver five dry measures used in former times, iron sheet building stones or Herba Dendrobii oculati and allied species thereof.Return stomach, kidney channel.There is reinforcing stomach reg fluid, effect of nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.
Fructus Amomi: acrid in the mouth, warm in nature.Return board, stomach, kidney channel.For the dry mature fruit of zingiberaceous plant Fructus Amomi, green shell sand or SEMEN AMOMI LONGILIGULA.There is removing dampness appetizing, warming spleen and stopping diarrha, the antiabortive effect of regulating the flow of vital energy.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Nodus Nelumbinis Rhizomatis: sweet in the mouth, puckery, property is flat.Return liver, lung, stomach warp.For the dry root stipes portion of nymphaeaceae plant lotus.There is hemostasis, effect of repercussive, for spitting blood, spitting of blood, epistaxis, hematuria, metrorrhagia.
Bacillus cereus: be the one in bacillus.Growth temperature range 20-45 DEG C, 10 DEG C of following poor growths or do not grow.Being present in soil, water, air and animal intestinal etc. locates.Bacillus cereus enters after intestinal, staphylococcic growth is had to Inhibiting and protective function, to bifidus bacillus, lactobacillus, the growth of the human body probioticss such as peptostreptococcus has facilitation, consume the too much oxygen in intestinal, create anaerobic environment, promote the growth of anaerobe, adjust alteration of intestinal flora, improve microecological environment, reach the object that is suitable for useful anaerobe existence, suppresses harmful aerobic bacteria.Bacillus cercus can produce antibiotic substance, suppresses harmful microbe breeding, and the nutritional labeling in degraded soil, improves the ecological environment.Can produce bacterialprotease, can be used for retting, be the mensuration bacterium of various antibiotic antibacterial activities.For suffering from diarrhoea, the treatment of bowel dysfunction and enteritis.
technical advantage of the present invention is mainly reflected in:
1. the principle of medicament of the present invention based on traditional Chinese medical herbal treatment, is to make on the basis of having studied lot of documents, pharmacology work and clinical trial, and effect is remarkable.
2. this medicament selected materials is Chinese medicine material, has no side effect.
3. medical material medicine source is easy to get, with low cost, can not bring large financial burden to patient.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.Raw materials usedly in embodiment all can buy from market, such as Massa Medicata Fermentata is purchased from Meishan Di Kang Chinese crude drug company limited, specification is every heavy 10g, every heavy 20g, and every heavy 30g all has.Fructus Gardeniae is purchased from purchased from Bozhou Chinese crude drug trade center.
embodiment 1the viable bacteria mixture of relieve chronic dysentery and bowel dysfunction, take off the primary raw material of stating weight proportion and be prepared from (getting 20g for every part): 4 parts of Fructus Evodiaes, 10 parts of Fructus Gardeniaes, 12 parts of Massa Medicata Fermentata, 12 parts of Fructus Schisandrae Chinensis, 12 parts of Poria cum Radix Pinis, 15 parts of Fructus Crataegis, 9 parts of Herba Dendrobiis, 12 parts of Fructus Amomis, 10 parts of Nodus Nelumbinis Rhizomatis, 1.0 parts of bacillus cereuss.
The preparation method of the viable bacteria mixture oral liquid of above-mentioned relieve chronic dysentery and bowel dysfunction is:
(1) Fructus Gardeniae, Fructus Schisandrae Chinensis, Fructus Amomi and Nodus Nelumbinis Rhizomatis are placed in to marmite, fry to 5 sixty percent ripe, be ground into fine powder, cross 100 mesh sieves;
(2) Fructus Evodiae is placed in to marmite, adds water, moderate heat decocts 50 minutes;
(3) Massa Medicata Fermentata, Poria cum Radix Pini, Fructus Crataegi, Herba Dendrobii and step (1) gains are placed in to the marmite of step (2), add water, intense fire is fried open, slow fire boiling 30 minutes;
(4) in the time that temperature is cooled to 35 DEG C, add Bacillus cereus and sucrose, leave standstill 2 hours, filter, obtain filtrate, cooling, be concentrated into 1/2 of original solution, sterile packaged.
The instructions of taking of oral liquid of the present invention: each serving using 10ml, every day 2-3 time, with the warm boiled water of 35 DEG C of left and right, 3 days courses for the treatment of.
model case oneold XX, female, 38 years old, Weifang, Shandong Province from Shouguang City.Long-term dysentery, often the product of more edible dysentery relieving all just starts effective at every turn, and be easy to form dependency, and be all to start to eat like a bird, amount was increasing afterwards, effect is not but felt any better, as long as one cut out, and dysentery again again, for a long time, again and again, the situation of dysentery is not only improved, also feel more and more serious, the most significantly performance is exactly to cause digestive system function to get muddled, and causes malnutrition, long mottle on the face, pachylosis is lackluster.
Afterwards, household had heard the viable bacteria mixture of relieve chronic dysentery of the present invention and bowel dysfunction, took the viable bacteria mixture oral liquid of embodiment 1 gained relieve chronic dysentery and bowel dysfunction after 2 days, and dysentery just obviously improves, and stomachache has also obviously obtained alleviation.Take every day 3 times, taking on an empty stomach, adhere to that the viable bacteria mixture oral liquid of embodiment 1 gained relieve chronic dysentery and bowel dysfunction is after 5 days, the symptom of dysentery disappears substantially.Take the viable bacteria mixture oral liquid of embodiment 1 gained relieve chronic dysentery and bowel dysfunction after 6 days, change every day 1-2 time into, get up to take once in the morning, before sleeping evening, take once, adhere to 10 days, improved the absorption of the intestines and stomach to food, also improved underfed situation, CHENNU morale color of today also becomes fine.
embodiment 2the viable bacteria mixture of relieve chronic dysentery and bowel dysfunction, take off the primary raw material of stating weight proportion and be prepared from (getting 20g for every part): 3.5 parts of Fructus Evodiaes, 8 parts of Fructus Gardeniaes, 9 parts of Massa Medicata Fermentata, 10 parts of Fructus Schisandrae Chinensis, 9 parts of Poria cum Radix Pinis, 12 parts of Fructus Crataegis, 8 parts of Herba Dendrobiis, 10 parts of Fructus Amomis, 8 parts of Nodus Nelumbinis Rhizomatis, 0.8 part of bacillus cereus.
The preparation method of the viable bacteria mixture powder of above-mentioned relieve chronic dysentery and bowel dysfunction is:
(1) Fructus Gardeniae, Fructus Schisandrae Chinensis, Fructus Amomi and Nodus Nelumbinis Rhizomatis are ground into fine powder, cross 60 mesh sieves, after mixing, put into glass container, with 6 times of amount alcohol reflux 2 times, 3 hours for the first time, 1.5 hours for the second time, merge extractive liquid,, respectively must medicinal liquid and medicinal residues;
(2) Fructus Evodiae is placed in to marmite, adds step (1) gained medicinal liquid, moderate heat decocts 50 minutes;
(3) Massa Medicata Fermentata, Poria cum Radix Pini, Fructus Crataegi, Herba Dendrobii are placed in to the marmite of step (2), add water, intense fire is fried open, slow fire boiling 30 minutes;
(4) in the time that temperature is cooled to 35 DEG C, add Bacillus cereus and sucrose, leave standstill 2 hours, filter, obtain filtrate, add step (1) gained medicinal residues, cooling, be condensed into thick paste (45 DEG C), be modulated into the soft material that light pressure is fallen apart, cross 100 mesh sieves, dry, pulverize, obtain powder.
The instructions of taking of powder of the present invention: each serving using 5g/ bag, every day 2-3 time, with the warm boiled water of 35 DEG C of left and right, 3 days courses for the treatment of.
model case twograndson XX, man, 36 years old, the Huantai people of Zibo City of Shandong Province.Toil away and add that diet is irregular, Mr. Li usually can feel stomachache, until 2011, there is the symptom of abdominal colic in Mr. Li, he thinks carefully not have a meal and cause at ordinary times, seeks medical advice and medicine with regard to oneself.Incipient time, the phenomenon of really suffering from abdominal pain alleviates to some extent, but after having eaten a period of time, has not just taken effect very much, has even also occurred serious dysentery, and Mr. Li is very worried to this.He starts to recognize that the disease of oneself is so simple in may not imagining.After having eaten some medicines, Mr.'s Li dysentery phenomenon has had certain improvement, and he does not just rethink the thing for the treatment of.But unexpectedly, soon occur again dysentery, and situation is very serious, finally go to hospital to check, find that Mr.'s Li mucous membrane of colon breakage is very serious, after hospitalize a period of time, symptom is eased, and can soon occur again dysentery.
On August 16th, 2012, in the time that Mr. Li feels hopeless, be not intended to pleasant to the ear friend and introduced the viable bacteria mixture of relieve chronic dysentery and bowel dysfunction.At the viable bacteria mixture powder of taking embodiment 2 gained relieve chronic dysentery and bowel dysfunction after 3 days, the phenomenon of stomachache, dysentery has obtained obvious improvement, the viable bacteria mixture powder that continues to take embodiment 2 gained relieve chronic dysentery and bowel dysfunction is after 3 days, remove examination in hospital, find that the damaged situation of mucous membrane of colon disappears, nowadays pass by soon 2 years, also do not occurred the situation of stomachache, dysentery, recovered health completely.
embodiment 3the viable bacteria mixture of relieve chronic dysentery and bowel dysfunction, takes off the primary raw material of stating weight proportion and is prepared from (getting 30g for every part): 3 parts of Fructus Evodiaes, 7 parts of Fructus Gardeniaes, 8 parts of Massa Medicata Fermentata, 8 parts of Fructus Schisandrae Chinensis, 8 parts of Poria cum Radix Pinis, 11 parts of Fructus Crataegis, 8 parts of Herba Dendrobiis, 9 parts of Fructus Amomis, 7 parts of Nodus Nelumbinis Rhizomatis, 0.6 part of bacillus cereus.
The preparation method of the viable bacteria mixture capsule of above-mentioned relieve chronic dysentery and bowel dysfunction is:
(1) Fructus Gardeniae, Fructus Schisandrae Chinensis, Fructus Amomi and Nodus Nelumbinis Rhizomatis are ground into fine powder, cross 60 mesh sieves, after mixing, put into glass container, with 6 times of amount alcohol reflux 2 times, 3 hours for the first time, 1.5 hours for the second time, merge extractive liquid,, respectively must medicinal liquid and medicinal residues;
(2) Fructus Evodiae is placed in to marmite, adds step (1) gained medicinal liquid, moderate heat decocts 50 minutes;
(3) Massa Medicata Fermentata, Poria cum Radix Pini, Fructus Crataegi, Herba Dendrobii are placed in to the marmite of step (2), add water, intense fire is fried open, slow fire boiling 30 minutes;
(4) in the time that temperature is cooled to 35 DEG C, add Bacillus cereus and sucrose, leave standstill 2 hours, filter, obtain filtrate, add step (1) gained medicinal residues, cooling, be condensed into thick paste (45 DEG C), be modulated into the soft material that light pressure is fallen apart, cross 100 mesh sieves, dry, according to the metering of 0.5g/ grain, be processed into capsule formulation according to the preparation for processing of capsule.
The instructions of taking of capsule of the present invention: every day 3 times, each 3-5 grain, with the warm boiled water of 35 DEG C of left and right, 3 days courses for the treatment of.
test examplethe clinical practice of the viable bacteria mixture capsule of embodiment 3 gained relieve chronic dysentery and bowel dysfunction: in February, 2010-2012 year February, screened 200 routine patients, wherein women's 100 examples, male's 100 examples.Test 2 weeks before, carries out Continuous Observation to this crowd, records symptom and variation, be divided at random two groups, experimental group and matched group, experimental group is taken the viable bacteria mixture capsule of embodiment 3 gained relieve chronic dysentery and bowel dysfunction, and matched group is taken other medicine (norfloxacin).Using method is: experimental group, and take half an hour ante cibum, every day three times, each 3-5 grain, 3 days courses for the treatment of; Matched group, take half an hour ante cibum, every day 3 times, each 2.Curative effect situation criterion: cure: after after 3 courses for the treatment of of drug administration, malaise symptoms disappears completely, energy and muscle power obviously strengthen; Effective: after 3 courses for the treatment of of drug administration, malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: the unchanged or later stage recurrence of malaise symptoms after 3 courses for the treatment of of drug administration.Wherein, total effective rate comprises cure rate and effective percentage.Result is as shown in table 1.
Table 1
Therapeutic effect: as can be seen from Table 1, take the cure rate of viable bacteria mixture capsule of relieve chronic dysentery of the present invention and bowel dysfunction up to 78%, total effective rate 98%, inefficiency is only 2%; And the cure rate of taking norfloxacin only 31%, total effective rate 86%, inefficiency is up to 14%.Can find out: the successful of taking the viable bacteria mixture capsule of relieve chronic dysentery of the present invention and bowel dysfunction is better than taking norfloxacin.
Table 2
As can be seen from Table 2: take the viable bacteria mixture capsule 3 days of relieve chronic dysentery of the present invention and bowel dysfunction, more than 52% patient feels to take a turn for the better to some extent, and malaise symptoms improves; The viable bacteria mixture capsule 6 days of taking relieve chronic dysentery of the present invention and bowel dysfunction, more than 74% patient feels to take a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; The viable bacteria mixture capsule 9 days of taking relieve chronic dysentery of the present invention and bowel dysfunction, more than 92% patient feels to take a turn for the better to some extent, and appetite obviously strengthens, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and some patients were self-induction is without malaise symptoms.Can find out that the successful of experimental group of the viable bacteria mixture capsule of taking relieve chronic dysentery of the present invention and bowel dysfunction is higher than the matched group of oral western medicine norfloxacin.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clearly disclosed or obtain undoubtedly according to the written description of file, all should think the claimed scope of this patent.

Claims (10)

1. the viable bacteria mixture of relieve chronic dysentery and bowel dysfunction, it is characterized in that, take off the primary raw material of stating weight proportion and be prepared from: Fructus Evodiae 2-4 part, Fructus Gardeniae 3-10 part, Massa Medicata Fermentata 4-12 part, Fructus Schisandrae Chinensis 5-12 part, Poria cum Radix Pini 4-12 part, Fructus Crataegi 6-15 part, Herba Dendrobii 6-9 part, Fructus Amomi 5-12 part, Nodus Nelumbinis Rhizomatis 3-10 part, bacillus cereus 0.3-1.0 part.
2. viable bacteria mixture according to claim 1, it is characterized in that, take off the primary raw material of stating weight proportion and be prepared from: Fructus Evodiae 2.5-3.5 part, Fructus Gardeniae 5-8 part, Massa Medicata Fermentata 7-9 part, Fructus Schisandrae Chinensis 7-10 part, Poria cum Radix Pini 7-9 part, Fructus Crataegi 9-12 part, Herba Dendrobii 7-8 part, Fructus Amomi 7-10 part, Nodus Nelumbinis Rhizomatis 5-8 part, bacillus cereus 0.5-0.8 part.
3. viable bacteria mixture according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: 3 parts of Fructus Evodiaes, 7 parts of Fructus Gardeniaes, 8 parts of Massa Medicata Fermentata, 8 parts of Fructus Schisandrae Chinensis, 8 parts of Poria cum Radix Pinis, 11 parts of Fructus Crataegis, 8 parts of Herba Dendrobiis, 9 parts of Fructus Amomis, 7 parts of Nodus Nelumbinis Rhizomatis, 0.6 part of bacillus cereus.
4. according to the arbitrary described viable bacteria mixture of claim 1-3, it is characterized in that, this viable bacteria mixture is made to pharmaceutically acceptable oral liquid, powder or capsule.
5. viable bacteria mixture according to claim 4, is characterized in that, the preparation method of described oral liquid is:
(1) Fructus Gardeniae, Fructus Schisandrae Chinensis, Fructus Amomi and Nodus Nelumbinis Rhizomatis are placed in to marmite, fry to 5 sixty percent ripe, be ground into fine powder, cross 80-120 mesh sieve (preferably 90-110 mesh sieve, is more preferably 100 mesh sieves);
(2) Fructus Evodiae is placed in to marmite, adds water, moderate heat decocts 40-60 minute (preferably 45-55 minute, is more preferably 50 minutes);
(3) Massa Medicata Fermentata, Poria cum Radix Pini, Fructus Crataegi, Herba Dendrobii and step (1) gains are placed in to the marmite of step (2), intense fire is fried open, slow fire boiling 20-40 minute (preferably 25-35 minute, is more preferably 30 minutes);
(4) while treating that temperature is cooled to 20 DEG C-45 DEG C (preferably 25 DEG C-40 DEG C, be more preferably 35 DEG C), add Bacillus cereus and sucrose, standing 1-3 hour (preferably 1.5-2.5 hour, be more preferably 2 hours), filter, obtain filtrate, cooling, be concentrated into 1/2 of original solution, sterile packaged.
6. the preparation method of oral liquid according to claim 5, is characterized in that: step (4) dosage of sucrose is the preferred 3.5%-4.5% of 3%-5%(of step (3) gained medicinal liquid, is more preferably 4%).
7. viable bacteria mixture according to claim 4, is characterized in that, the preparation method of described powder is:
(1) Fructus Gardeniae, Fructus Schisandrae Chinensis, Fructus Amomi and Nodus Nelumbinis Rhizomatis are ground into fine powder, cross 40-80 mesh sieve (preferably 50-70 mesh sieve, is more preferably 60 mesh sieves), after mixing, put into glass container, with 6 times of amount alcohol reflux 2 times, 2-4 hour for the first time (preferably 2.5-3.5 hour, is more preferably 3 hours), 1-2 hour for the second time (preferably 1.2-1.8 hour, be more preferably 1.5 hours), merge extractive liquid,, obtains respectively medicinal liquid and medicinal residues;
(2) Fructus Evodiae is placed in to marmite, adds step (1) gained medicinal liquid, moderate heat decocts 40-60 minute (preferably 45-55 minute, is more preferably 50 minutes);
(3) Massa Medicata Fermentata, Poria cum Radix Pini, Fructus Crataegi, Herba Dendrobii are placed in to the marmite of step (2), intense fire is fried open, slow fire boiling 20-40 minute (preferably 25-35 minute, is more preferably 30 minutes);
(4) in the time that temperature is cooled to 20 DEG C-45 DEG C, add Bacillus cereus and sucrose, standing 1-3 hour (preferably 1.5-2.5 hour, be more preferably 2 hours), filter, obtain filtrate, add step (1) gained medicinal residues, cooling, be condensed into thick paste (45 DEG C), be modulated into the soft material that light pressure is fallen apart, cross 80-120 mesh sieve (preferably 90-110 mesh sieve, is more preferably 100 mesh sieves), dry, pulverize, obtain powder.
8. viable bacteria mixture according to claim 4, is characterized in that, the preparation method of described capsule is:
(1) Fructus Gardeniae, Fructus Schisandrae Chinensis, Fructus Amomi and Nodus Nelumbinis Rhizomatis are ground into fine powder, cross 40-80 mesh sieve (preferably 50-70 mesh sieve, is more preferably 60 mesh sieves), after mixing, put into glass container, with 6 times of amount alcohol reflux 2 times, 2-4 hour for the first time (preferably 2.5-3.5 hour, is more preferably 3 hours), 1-2 hour for the second time (preferably 1.2-1.8 hour, be more preferably 1.5 hours), merge extractive liquid,, obtains respectively medicinal liquid and medicinal residues;
(2) Fructus Evodiae is placed in to marmite, adds step (1) gained medicinal liquid, moderate heat decocts 40-60 minute (preferably 45-55 minute, is more preferably 50 minutes);
(3) Massa Medicata Fermentata, Poria cum Radix Pini, Fructus Crataegi, Herba Dendrobii are placed in to the marmite of step (2), intense fire is fried open, slow fire boiling 20-40 minute (preferably 25-35 minute, is more preferably 30 minutes);
(4) in the time that temperature is cooled to 20 DEG C-45 DEG C, add Bacillus cereus and sucrose, standing 1-3 hour (preferably 1.5-2.5 hour, be more preferably 2 hours), filter, obtain filtrate, add step (1) gained medicinal residues, cooling, be condensed into thick paste (45 DEG C), be modulated into the soft material that light pressure is fallen apart, cross 80-120 mesh sieve (preferably 90-110 mesh sieve, is more preferably 100 mesh sieves), dry, according to 0.4-0.6g/ grain (preferably 0.45-0.55g/ grain, is more preferably 0.5g/ grain) metering, be processed into capsule formulation according to the preparation for processing of capsule.
9. according to the preparation method of claim 7 and powder claimed in claim 8 and capsule, it is characterized in that: step (4) is treated temperature cooling (preferably 25 DEG C-40 DEG C, be more preferably 35 DEG C).
10. according to the preparation method of claim 7 and powder claimed in claim 8 and capsule, it is characterized in that: step (4) concentrated the relative density thick paste (preferably 1.25-1.35, is more preferably 1.3) that is 1.2-1.4.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104840827A (en) * 2015-06-08 2015-08-19 张雨秀 Stomach invigoration tablet for treating gastrointestinal dysfunction and preparation method of stomach invigoration tablet

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
史哲: "诸痢验方集锦", 《国医论坛》 *
李侠: "蜡样芽孢杆菌活菌制剂与蒙脱石联合治疗小儿病毒性腹泻", 《中国新药与临床杂志》 *
湖北中医学院附属医院菌痢疾科研小组: "中医对细菌性痢疾的认识和治疗", 《赤脚医生杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104840827A (en) * 2015-06-08 2015-08-19 张雨秀 Stomach invigoration tablet for treating gastrointestinal dysfunction and preparation method of stomach invigoration tablet

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