CN106620474B - Stomach-nourishing health-care medicine and preparation method thereof - Google Patents
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- CN106620474B CN106620474B CN201611239229.6A CN201611239229A CN106620474B CN 106620474 B CN106620474 B CN 106620474B CN 201611239229 A CN201611239229 A CN 201611239229A CN 106620474 B CN106620474 B CN 106620474B
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Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a stomach nourishing health-care medicine and a preparation method thereof. The stomach nourishing health care medicine has obvious effects on gastric acid, gastrectasia, stomachache, heartburn, nausea, vomiting, dyspepsia, alcohol addiction and other symptoms, takes the root cause and symptoms into consideration, has homology of medicine and food, and can provide a safe, effective, economic and reasonable stomach nourishing health care medicine for common people.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a stomach-nourishing health-care medicine and a preparation method thereof.
Background
The book Huangdi's classic on medicine has a speech: the spleen and stomach, barn officers and five flavors all over the entire area! The spleen and stomach are the earth of the middle-jiao of the human body, and the weakness of the spleen and stomach can cause malnutrition of the whole body and diseases caused by physical weakness. Some people seem to be profound, the spleen and the stomach are very weak, the dysfunction of the spleen and the stomach can occur without leaving much attention, many people who are troubled by stomach discomfort have been described in traditional Chinese medicine, and the terms of epigastric pain, fullness and fullness, acid regurgitation, gastric upset, anorexia and the like are used for describing the traditional Chinese medicine. The symptoms are manifested as satiety after meal, epigastric pain and discomfort, belching, anorexia, acid regurgitation, heartburn, vomiting, nausea or emaciation, anemia, diarrhea, etc. The traditional Chinese medicine considers that the occurrence of the disease is mostly related to diet, and the disease can be caused by uncooked cold diet, greasiness, pungency, overeating, eating less, irregular diet and the like. It can also be caused by exogenous pathogenic factors, emotional disorders, and constitutional weakness. The disease is mainly in the stomach and closely related to the liver and spleen. In therapeutic methods, the basic principle of regulating qi and harmonizing stomach is used, but the reason for the syndrome should be examined and the treatment should be examined.
The western medicine theory calls the symptoms as acute gastritis and chronic gastritis, and the acute gastritis has various etiologies, mainly including stress, physical and chemical injuries and acute bacterial infection. The occurrence of chronic gastritis is mainly related to infection of helicobacter pylori (Hp), and is also related to factors such as autoimmunity and bile reflux. Acute gastritis needs to remove the cause of the disease, actively treat primary diseases and wounds and correct the pathophysiological disorder caused by the primary diseases and the wounds. Drugs for inhibiting gastric acid secretion, such as omeprazole enteric capsules and ranitidine hydrochloride capsules, are commonly used. Chronic gastritis is also caused by elimination of the etiology, and Hp-related gastritis needs to be treated by eradicating Hp. However, other chronic gastritis has no specific treatment, and most chronic gastritis cannot reverse gastritis, so that the traditional Chinese medicine is mainly used for symptomatic treatment. The application of the medicine for protecting gastric mucosa comprises sucralfate, and Maizilin-S.
At present, the traditional Chinese medicine has slow effect, more symptoms, difficult grasp of patients and uncertain effect for treating the gastritis, and can be used as 'good medicine' if the symptoms can be improved; western medicines have large side effects generally, patients are not willing to accept the Western medicines, the treatment period is as long as 3-5 months, the treatment cost is high, Western medicines have no specific treatment for chronic gastritis, patients without symptoms generally advocate that symptomatic treatment is carried out only if symptoms exist.
Disclosure of Invention
The invention provides a stomach-nourishing health-care medicine and a preparation method thereof, overcomes the defects of the prior art, and can effectively solve the problems of slow effect and large side effect of western medicines in the traditional Chinese medicine for treating gastritis.
One of the technical schemes of the invention is realized by the following measures: the stomach-nourishing health medicine comprises, by weight, 1.4 to 3.4 parts of long pepper, 1.4 to 3.4 parts of galangal, 1.4 to 3.4 parts of dried orange peel, 0.8 to 2.8 parts of fingered citron, 0.8 to 2.8 parts of wrinkled gianthyssop herb, 0.8 to 2.8 parts of cinnamon, 0.2 to 2.2 parts of clove, 0.2 to 2.2 parts of liquorice, 79 to 81 parts of edible sodium bicarbonate and 4 to 6 parts of corn starch.
The following is a further optimization or/and improvement of one of the above-mentioned technical solutions of the invention:
the raw materials comprise, by weight, 2.4 parts of long pepper, 2.4 parts of galangal, 2.4 parts of dried orange peel, 1.8 parts of fingered citron, 1.8 parts of wrinkled gianthyssop, 1.8 parts of cinnamon, 1.2 parts of clove, 1.2 parts of liquorice, 80 parts of edible sodium bicarbonate and 5 parts of corn starch.
The stomach nourishing health care medicine is obtained by the following method: firstly, crushing long pepper, galangal, tangerine peel, fingered citron, wrinkled gianthyssop, cinnamon, clove and liquorice, sieving by a 100-mesh sieve, taking undersize materials, uniformly mixing to obtain eight-medicine mixture, performing cobalt-60 irradiation sterilization, and uniformly mixing the eight-medicine mixture and edible sodium bicarbonate to obtain a mixture; secondly, taking normal-temperature purified water with the mass of 1.5 times of that of the corn starch, dispersing the corn starch in the normal-temperature purified water, uniformly stirring, adding boiled purified water with the mass of 2.5 times of that of the corn starch, stirring while adding to form semitransparent starch paste, adding a mixture into the corn paste when the temperature of the corn paste is reduced to 55-60 ℃, and fully stirring and uniformly mixing to obtain a soft material which is held to be agglomerated and is pressed to be dispersed; thirdly, granulating by using a sieve with 14 meshes to 16 meshes to obtain granules, and then drying the granules until the water content of the granules is 2 percent to 3 percent to obtain dried granules; and fourthly, granulating, adding magnesium stearate accounting for 0.5 to 1 percent of the weight of the dried granules into the homogenized dried granules, mixing uniformly, and tabletting.
In the first step, the absorbed dose of the cobalt-60 is less than or equal to 6KGy during radiation sterilization, and the radiation time is 24 hours.
And in the third step, drying the particles in a dry hot air circulating oven at the temperature of 60-70 ℃ to obtain the dried particles.
In the fourth step, the pellets were granulated with a 14-mesh stainless steel net into uniform dry pellets.
The second technical scheme of the invention is realized by the following measures: a preparation method of a stomach-nourishing health-care medicine comprises the following steps: firstly, crushing long pepper, galangal, tangerine peel, fingered citron, wrinkled gianthyssop, cinnamon, clove and liquorice, sieving by a 100-mesh sieve, taking undersize materials, uniformly mixing to obtain eight-medicine mixture, performing cobalt-60 irradiation sterilization, and uniformly mixing the eight-medicine mixture and edible sodium bicarbonate to obtain a mixture; secondly, taking normal-temperature purified water with the mass of 1.5 times of that of the corn starch, dispersing the corn starch in the normal-temperature purified water, uniformly stirring, adding boiled purified water with the mass of 2.5 times of that of the corn starch, stirring while adding to form semitransparent starch paste, adding a mixture into the corn paste when the temperature of the corn paste is reduced to 55-60 ℃, and fully stirring and uniformly mixing to obtain a soft material which is held to be agglomerated and is pressed to be dispersed; thirdly, granulating by using a sieve with 14 meshes to 16 meshes to obtain granules, and then drying the granules until the water content of the granules is 2 percent to 3 percent to obtain dried granules; and fourthly, granulating, adding magnesium stearate accounting for 0.5 to 1 percent of the weight of the dried granules into the homogenized dried granules, mixing uniformly, and tabletting.
The following is further optimization or/and improvement of the second technical scheme of the invention:
in the first step, the absorbed dose of the cobalt-60 is less than or equal to 6KGy during radiation sterilization, and the radiation time is 24 hours.
And in the third step, drying the particles in a dry hot air circulating oven at the temperature of 60-70 ℃ to obtain the dried particles.
In the fourth step, the pellets were granulated with a 14-mesh stainless steel net into uniform dry pellets.
The stomach nourishing health care medicine has obvious effects on gastric acid, gastrectasia, stomachache, heartburn, nausea, vomiting, dyspepsia, alcohol addiction and other symptoms, takes the root cause and symptoms into consideration, has homology of medicine and food, and can provide a safe, effective, economic and reasonable stomach nourishing health care medicine for common people.
Detailed Description
The present invention is not limited by the following examples, and specific embodiments may be determined according to the technical solutions and practical situations of the present invention. The various chemical reagents and chemical articles mentioned in the invention are all the chemical reagents and chemical articles which are well known and commonly used in the prior art unless otherwise specified; the percentages in the invention are mass percentages unless otherwise specified; the water in the present invention is tap water or purified water, if not specifically mentioned; the solution in the present invention is an aqueous solution in which the solvent is water, for example, a hydrochloric acid solution is an aqueous hydrochloric acid solution, unless otherwise specified; ordinary temperature in the present invention generally means a temperature of 15 ℃ to 25 ℃, and is generally defined as 25 ℃.
The invention is further described below with reference to the following examples:
embodiment 1, the stomach-nourishing health-care medicine comprises, by weight, 1.4 to 3.4 parts of long pepper, 1.4 to 3.4 parts of galangal, 1.4 to 3.4 parts of dried orange peel, 0.8 to 2.8 parts of fingered citron, 0.8 to 2.8 parts of wrinkled gianthyssop herb, 0.8 to 2.8 parts of cinnamon, 0.2 to 2.2 parts of clove, 0.2 to 2.2 parts of liquorice, 79 to 81 parts of edible sodium bicarbonate, and 4 to 6 parts of corn starch.
Example 2, the raw materials of the stomach-nourishing health-care medicine comprise, by weight, 1.4 parts or 3.4 parts of long pepper, 1.4 parts or 3.4 parts of galangal, 1.4 parts or 3.4 parts of dried orange peel, 0.8 part or 2.8 parts of fingered citron, 0.8 part or 2.8 parts of wrinkled gianthyssop herb, 0.8 part or 2.8 parts of cinnamon, 0.2 part or 2.2 parts of clove, 0.2 part or 2.2 parts of liquorice, 79 parts or 81 parts of edible sodium bicarbonate and 4 parts or 6 parts of corn starch.
Embodiment 3, the stomach-nourishing health-care medicine comprises, by weight, 2.4 parts of long pepper, 2.4 parts of galangal, 2.4 parts of dried orange peel, 1.8 parts of fingered citron, 1.8 parts of wrinkled gianthyssop herb, 1.8 parts of cinnamon, 1.2 parts of clove, 1.2 parts of liquorice, 80 parts of edible sodium bicarbonate and 5 parts of corn starch.
Example 4, as an optimization of the above examples, the stomach nourishing health care medicine is obtained by the following method: firstly, crushing long pepper, galangal, tangerine peel, fingered citron, wrinkled gianthyssop, cinnamon, clove and liquorice, sieving by a 100-mesh sieve, taking undersize materials, uniformly mixing to obtain eight-medicine mixture, performing cobalt-60 irradiation sterilization, and uniformly mixing the eight-medicine mixture and edible sodium bicarbonate to obtain a mixture; secondly, taking normal-temperature purified water with the mass of 1.5 times of that of the corn starch, dispersing the corn starch in the normal-temperature purified water, uniformly stirring, adding boiled purified water with the mass of 2.5 times of that of the corn starch, stirring while adding to form semitransparent starch paste, adding a mixture into the corn paste when the temperature of the corn paste is reduced to 55-60 ℃, and fully stirring and uniformly mixing to obtain a soft material which is held to be agglomerated and is pressed to be dispersed; thirdly, granulating by using a sieve with 14 meshes to 16 meshes to obtain granules, and then drying the granules until the water content of the granules is 2 percent to 3 percent to obtain dried granules; fourthly, firstly granulating, then adding magnesium stearate accounting for 0.5 to 1 percent of the weight of the dried granules into the homogenized dried granules, uniformly mixing, and then tabletting
Example 5 as an optimization of example 4, in the first step, the absorbed dose of cobalt-60 irradiation for sterilization is less than or equal to 6KGy, and the irradiation time is 24 hours.
Example 6, as an optimization of examples 4 and 5, in the third step, the granules were dried in a dry hot air circulation oven at 60 ℃ to 70 ℃ to obtain dried granules.
Example 7 as an optimization of examples 4, 5 and 6, in the fourth step, homogenized dry granules were sized with a 14 mesh stainless steel mesh.
The pharmacology of the invention is as follows:
1. long pepper
Pungent and hot in property, entering stomach and large intestine meridians, warm middle energizer, dispel cold, expel qi and alleviate pain. It can be used for treating psychroalgia of heart and abdomen, emesis, acid regurgitation, rugitus, diarrhea, cold dysentery, hernia of yin, headache, nasosinusitis, and toothache.
The pharmacological action of the long pepper is as follows: 1. the fructus Piperis Longi volatile oil has tranquilizing, analgesic, and analgesic effects; 2. the fructus Piperis Longi ethyl acetate extract has strong relaxation effect on intestinal canal smooth muscle, and fructus Piperis Longi oil has broad-spectrum antibacterial effect and has inhibitory effect on Staphylococcus aureus, Bacillus dysenteriae, typhoid bacillus, tuberculous iris lactea, etc.; 3. the long pepper ethanol extract has obvious protection effect on experimental gastric ulcer and also has obvious inhibition effect on the amount of gastric juice and the total acidity of gastric juice.
Galangal
Pungent flavor and warm nature. Has the effects of warming stomach, dispelling cold, promoting qi circulation, resolving food stagnation and relieving pain. It can be used for treating abdominal pain due to cold, vomiting and diarrhea due to stomach cold, dyspepsia, and dyspepsia. It is recorded in Ben Cao Shi Xin to treat epigastric cold pain, because it can warm stomach, dispel cold, promote digestion and sober up. "
Pharmacological action of galangal:
1. effects on the digestive system, (1) regulating gastric function: the decoction can strongly inhibit gastrointestinal propulsion movement, but can promote gastric emptying. Galangal, evodia rutaecarpa 1: the mixed solution 1 has the effects of resisting stress ulcer of a rat, inhibiting gastric motility, reducing gastric tension, reducing contraction amplitude, inhibiting gastric acid secretion and the like. (2) Regulating intestinal function: the decoction has the effects of exciting intestinal canal, resisting intestinal activity caused by atropine and epinephrine, and exciting intestinal canal by histamine-like and epinephrine-like effects. Rhizoma Alpiniae Officinarum contains substances for inhibiting intestinal contraction caused by histamine, and can obviously inhibit rabbit intestinal tension and contraction amplitude, and has similar atropine-like effect. (3) Anti-gastric ulcer: the water extract can obviously resist water immersion stress ulcer, and can prevent acute injury of gastric mucosa caused by necrosis-causing substances. (4) Promoting gastric secretion: the leachate has the effect of stimulating the increase of gastric acid output, the total acid output is 3 times of that of a control group within 3 hours after the perfusion, and meanwhile, the vomit of animals is increased and the mucus in gastric juice is increased. (5) And (3) resisting diarrhea: the aqueous extract has significant resistance to diarrhea caused by castor oil and senna leaf. (6) Cholagogic: the water extract has obvious cholagogic effect when administered in duodenum.
Anti-inflammatory and analgesic
(1) Anti-inflammatory: the water extract can inhibit auricle swelling, plantar swelling and capillary permeability increase when administered to mice.
Analgesia: the water extract can inhibit writhing reaction and prolong the reaction to thermal pain stimulation. Its anti-inflammatory analgesic effect may be related to the inhibition of the release of prostatic synthesis.
Antibacterial and antifungal effects: the water decoction has different degrees of antibacterial action on 10 gram-positive bacteria. The 3 kinds of piperitol derivatives have strong fungus inhibiting effect.
Dried orange peel
Tangerine peel, pericarpium Citri Tangerinae, with warm nature, pungent and bitter taste, enters spleen and lung meridians. Has effects of regulating qi-flowing, invigorating spleen, eliminating dampness, eliminating phlegm, and activating qi-flowing.
The pharmacological action of the dried orange peel is as follows: and (3) aiding digestion: the bitter substances of pericarpium Citri Tangerinae are "limonoids" represented by limonin and bitter principle, which have mild taste, are easily dissolved in water, and are helpful for digestion of food. The pericarpium Citri Tangerinae contains volatile oil, hesperidin, vitamin B, C, etc., and the volatile oil has mild irritation effect on gastrointestinal tract, and can promote secretion of digestive juice, eliminate intestinal tract pneumatosis and stimulate appetite.
Finger citron
Pungent and warm, pungent, bitter and sour in flavor, and enter liver, spleen, stomach and lung meridians. Has effects of dispersing stagnated liver qi, regulating stomach function, relieving pain, eliminating dampness and eliminating phlegm.
The pharmacological action of fingered citron: 1. the finger citron alcohol extract has obvious inhibition effect on intestinal smooth muscle. 2. The fingered citron also has the effects of stress resistance, immunity regulation, tumor resistance and the like.
Agastache rugosus
Huo Xiang is pungent in flavor and slightly warm in nature, and enters spleen, stomach and lung meridians. Fragrant, resolving turbidity, regulating the middle warmer, arresting vomiting, relieving exterior syndrome and clearing summer-heat. Can be used for treating damp obstruction in middle warmer, abdominal distention, emesis, summer-heat dampness exterior syndrome, early stage of damp-warm syndrome, fever, listlessness, chest distress, cold-dampness, summer-heat, abdominal pain, emesis, diarrhea, nasosinusitis, and headache.
The pharmacological action of ageratum is as follows: 1. the agastache rugosus has the functions of regulating gastrointestinal function, promoting gastric secretion and enhancing digestion. 2. The antifungal agent has strong antifungal and antibacterial effects in a water decoction test tube.
Cortex Cinnamomi
Cinnamon has the functions of warming spleen and stomach, invigorating stomach, warming waist and knees, and treating abdominal cold and flatulence due to intense heat and pungent and sweet taste.
The pharmacological action of cinnamon: 1. effects on the central nervous system: the cinnamaldehyde is infused into the stomach at 250-500 mg/kg, so that the spontaneous activity of the mouse can be reduced, and the excessive activity generated by the amphetamine can be resisted; the mouse tail pressing method or the abdominal cavity injection acetic acid writhing method shows that the cinnamaldehyde has the analgesic effect; 2. antiulcer effect: the cinnamon water extract is injected into the abdominal cavity, so that stress ulcer of a rat can be prevented, gastric lavage or intraperitoneal injection can also inhibit gastric ulcer of the rat caused by 5-hydroxytryptamine, and the anti-ulcer effect is not only due to inhibition of gastric secretion, but also promotes blood flow of gastric mucosa; 3. bacteriostasis: the ethyl ether and ethanol leachate of cortex Cinnamomi has antibacterial effect on gram-positive bacteria and fungi.
Clove
Flos Caryophylli is pungent in flavor and warm in nature, and has effects of warming middle-jiao, lowering adverse qi, invigorating kidney and tonifying yang. It can be used for treating abdominal psychroalgia, singultus, emesis, diarrhea, kidney deficiency, sexual impotence, soreness of waist and knees, and dorsal furuncle.
The pharmacological action of clove: 1. effects on the digestive system: (1) anti-gastric ulcer; can inhibit experimental gastric ulcer formation in rat. The clove volatile oil and the eugenol can obviously increase gastric mucus secretion, but the acidity is not increased. Eugenol may be an anti-ulcer active ingredient; (2) stomach invigorating: can relieve abdominal distention, enhance digestion ability, and relieve nausea and emesis; (3) inhibition of intestinal excitation: the water decoction can inhibit spontaneous contraction of isolated rabbit intestine and resist the excitation of acetylcholine, histamine, etc. on isolated intestinal canal; (4) the water extract and eugenol can resist large intestine diarrhea and intestinal cavity hydrops caused by folium sennae or castor oil. 2. Sobering: the flos Caryophylli has pleasant fragrance and has anti-hangover effect. "compendium of materia Medica": clove kills alcohol poison. Qing Dynasty Zhouyang also has a sentence cloud in clove and rhyme: the brim is dense, people are difficult to bend, and people feel fragrant and easy to wake up. "3, anti-pathogen: oleum Caryophylli and eugenol have broad-spectrum antibacterial effect, and ellagitannin in flos Caryophylli has effect in resisting herpes simplex virus. The water decoction or ethanol extract has broad-spectrum antifungal or killing effect. Eugenol has remarkable killing effect on Candida albicans and Cryptococcus neoformans. The aqueous extract can kill ascaris suum and ascaris suum. The clove oil has stronger effect than the decoction. The clove oil, the eugenol and the acetyl eugenol have strong killing effect on trichomonas.
Licorice root, radix Glycyrrhizae
The nature is flat; sweet in taste; it enters heart, spleen, lung and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. For: weakness of spleen and stomach, lassitude and hypodynamia, palpitation and shortness of breath, cough with profuse sputum, spasm and pain of abdomen and limbs, carbuncle and sore, and relieving toxicity and strong nature of the medicine.
Pharmacological action of licorice: 1. the extractum without glycyrrhizin and flavonoid glycoside in licorice has obvious effect of protecting rat experimental ulcer. 2. The Glycyrrhrizae radix preparation has effects of promoting stomach mucus formation and secretion, prolonging epithelial cell life, and resisting inflammation, and can be used for treating chronic ulcer and duodenal ulcer. 3. Licoflavone has antiinflammatory, spasmolytic and antacid effects.
Edible sodium bicarbonate
Is a weak alkaline substance, can be used for conditioning the internal environment of the body at ordinary times, and has more obvious effect on conditioning intestinal diseases. The sodium bicarbonate can neutralize gastric acid, dissolve mucus, reduce viscosity of digestive juice, enhance gastrointestinal absorption, strengthen stomach, inhibit acid and stimulate appetite, and promote metabolism in body.
According to the invention, 8 pungent and warm traditional Chinese medicine food materials are selected to be matched with edible sodium bicarbonate to form the health food, so that the health food has the effects of warming the middle-jiao and invigorating the stomach, activating the spleen and regulating qi, and relieving hyperacidity and pain, and is mainly used for treating symptoms such as gastric acid, gastrectasia, stomachache, heartburn, nausea, vomiting, dyspepsia and the like. Acute and chronic gastritis, superficial gastritis, atrophic gastritis, and alcohol-drinking difficulty.
The stomach nourishing health care medicine obtained according to the embodiment of the invention has the following clinical effects:
example 1: the patient is a woman in age of 66 years, and has symptoms of abdominal pain, abdominal fullness, heartburn, nausea and vomiting for 7 years. Gastroscopy suggests chronic atrophic gastritis and reflux gastritis. Famotidine is taken for 2 years, with good time and bad time. The stomach nourishing health care medicine of the invention is taken 5 granules at a time and 3 times a day. After three days, the symptoms of nausea, vomiting and heartburn are obviously improved; the abdominal pain and fullness symptom is relieved after taking for 2 weeks; after the medicine is continuously taken for 30 days, the symptom disappears and returns to normal, the patient keeps taking the medicine for 3 months, and the gastroscope review indicates that the gastric mucosa congestion disappears and the gastric juice is clear and recovered.
Example 2: patients with Liu female, age 44, abdominal fullness and distention, aversion to pressure, belching with fetid odor and acid regurgitation, thick and greasy tongue coating, nausea and vomiting for 3 years. Multiple gastroscopies all suggest diffuse superficial gastritis. The stomach-warming and comfortable medicinal granules are taken intermittently for 2 months, the effect is not good, and the stomach-nourishing health-care medicine is taken 5 granules at a time and 3 times a day. After 7 days, abdominal fullness and distention, eructation and putrefaction and acid regurgitation are obviously improved; nausea and vomiting were reduced after two weeks of continued administration; after the patient insists on taking the medicine for 20 days, the stomach and the abdomen have no uncomfortable feeling, and after the patient is firmly taken for 2 months, the gastritis is prompted to recover through gastroscopy.
Example 3: the patient is old in 16 years, belching, acid regurgitation, nausea, vomiting and preferring to press. The Sanjiuweitai granules are taken for 1 week and slightly relieved, and the stomach nourishing health care medicine is taken 5 granules at a time and 2 times a day. After 2 days, the eructation and acid regurgitation and nausea are obviously improved; after the oral liquid is continuously taken for 1 week, the stomach and the abdomen have no uncomfortable feeling, the appetite is good, and the digestion is good.
Example 4: the patient Dong's life is 49 years old, and has the symptoms of pantothenic acid and abdominal pain relieved after meals, and the symptoms of the pantothenic acid and the abdominal pain still exist after meals after gastroscopy to prompt the chronic gastritis, and after taking the omeprazole enteric-coated tablet and the lizardolene orally for 3 days, the symptoms of the pantothenic acid and the abdominal pain are all removed after 2 weeks, and after 2 months, the gastroscopy prompts the recovery of the chronic gastritis.
Example 5: mr. Zhao, age 42, white and greasy tongue coating, poor appetite, belch, rancidity, and stomach and abdomen distention after eating. Domperidone is taken for 1 week, which is not good enough. The stomach nourishing health care medicine of the invention is taken 5 granules at a time and 3 times a day. After 3 days, the symptoms are obviously improved; after the oral liquid is continuously taken for 1 week, the stomach and the abdomen have no uncomfortable feeling, the appetite is good, and the digestion is good.
Example 6: patients with 30 years old, abdominal distension, abdominal pain, anorexia, nausea, vomiting and loose stool. The stomach-nourishing health-care medicine is taken 5 granules at a time and 3 times a day, and no effect is seen after the stomach-nourishing health-care medicine is taken for 1 week. After 7 days, nausea and vomiting are relieved, and the anorexia is obviously improved; after the patient insists on taking the medicine for 15 days, the excrement is normal, the symptoms disappear, the patient continues to take the medicine for 1 month, and the gastroscope review prompts the recovery of the gastritis.
Example 7: patients with Mr. Song, age 41, dull pain and nausea in stomach for more than two months, particularly, stomach discomfort aggravated after drinking, performing gastroscopy to prompt congestion and edema of gastric fundus, gastric body and gastric angle mucous membranes and macular hyperemia of gastric antrum, and diagnosing gastritis, taking wrinkled Gianthyssop electuary and Sanjiuweitai granules orally for 3 days, the effect is not good, after taking the stomach nourishing health care medicine provided by the invention, 5 granules are taken once, 2 times a day, the symptoms are relieved after 2 days, the symptoms disappear after 7 days, and the patient continues to take for 3 weeks, and the gastric mucosa hyperemia and edema disappear after performing gastroscopy.
Example 8: patients who are 55 years old and have dull pain, belching, acid regurgitation, burning sensation, inappetence, nausea and vomiting at the upper abdomen are treated by taking medicines such as ranitidine orally in hospitals in local county, the condition of the patients is improved, the patients relapse after stopping the medicines, the patients need to take the stomach-nourishing health-care medicine disclosed by the invention to prompt the congestion and edema of the gastric-fundus and gastric-body mucous membranes, the chronic gastritis is diagnosed, 5 granules are taken once, the symptoms of belching and acid regurgitation disappear after 2 days, all symptoms are removed after 2 weeks, the patients continue to take the medicine for 3 weeks, and the symptoms of the gastric-fundus and gastric-body mucous membrane congestion are recovered after the stomach-nourishing health-care medicine is taken for.
Example 9: the patient plum female is 72 years old, has abdominal pain and abdominal distension, acid regurgitation and belching, poor appetite, and has the functions of prompting congestion and edema of mucous membranes at the fundus, corpus gastri and angle of stomach by gastroscopy, yellow and turbid mucus paste, thin mucous membrane at the part of antrum gastri, and diagnosis of superficial gastritis with atrophy and bile reflux. After the stomach nourishing health care medicine is taken 5 granules at a time, 2 times a day, 3 days, the symptoms of acid regurgitation and belching are relieved, all symptoms disappear after 2 weeks, the patient continues to take the medicine for 3 months, the gastroscope rechecks the congestion of mucous membrane for rehabilitation, and the mucus paste is clarified.
Example 10: patient Liu Fang, age 36, nausea, vomiting after drinking, stomach pain intolerance and headache desire to be split. Gastroscopy suggests acute gastritis. The stomach nourishing health care medicine of the invention is taken 5 granules at a time and 3 times a day. Half a day later, nausea, vomiting, and a reduction in stomachache; the headache is relieved after the continuous taking for 1 day; the symptoms disappear after the patient insists on taking the medicine for 3 days.
Example 11: the patient is Zhengsheng, 47 years old, vomits after drinking, nausea and anorexia of stomach, dizziness and difficulty in standing, and the food is taken 5 granules at a time and 3 times a day. After 1 day, the symptoms are obviously improved; after the medicine is continuously taken for 2 days, no discomfort feeling is caused in stomach and abdomen, the appetite is good, and dizziness disappears.
Example 12: the patient Liu is born 33 years old, needs to be rewarded continuously due to running business, is often difficult to feel uncomfortable in the stomach after drinking and has a headache desire to split, is ordered to take the food half an hour before drinking, takes 5 capsules once and takes 5 capsules after drinking, contacts the patient, and does not feel drunk and is not difficult after drinking according to the method.
Example 13: patients are born in the week and are 52 years old, about 1 jin of high-alcohol-content white spirit is drunk, nausea and vomiting are caused, the patients are difficult to feel in the stomach, blood is sent to the doctor for drawing blood to prompt that the blood alcohol content is 220 mg/100 ml, the patients are taken 8 granules of the stomach nourishing health care medicine, blood is drawn again after 2 hours to detect the blood alcohol content to be 107 mg/100 ml, and blood is drawn after 4 hours to detect the blood alcohol content to be 40 mg/100 ml. Under normal conditions, the metabolism of alcohol in a human body has a human body metabolism half-life, namely, the alcohol content in the human body is reduced by half after about 3 hours of drinking, and the alcohol content may be reduced by the remaining half after 6 hours. The data show that the stomach nourishing health care medicine has the obvious effect of accelerating alcohol metabolism.
According to the clinical experimental effects, the stomach nourishing health care medicine has obvious effects on symptoms such as gastric acid, gastrectasia, stomachache, heartburn, nausea, vomiting, dyspepsia, difficult drinking and the like, has both principal and secondary aspects, is homologous in medicine and food, and can provide a safe, effective, economic and reasonable stomach nourishing health care medicine for common people.
The technical characteristics form an embodiment of the invention, which has strong adaptability and implementation effect, and unnecessary technical characteristics can be increased or decreased according to actual needs to meet the requirements of different situations.
Claims (3)
1. The stomach-nourishing health medicine is characterized in that the raw materials comprise, by weight, 1.4 to 3.4 parts of long pepper, 1.4 to 3.4 parts of galangal, 1.4 to 3.4 parts of dried orange peel, 0.8 to 2.8 parts of fingered citron, 0.8 to 2.8 parts of wrinkled gianthyssop herb, 0.8 to 2.8 parts of cinnamon, 0.2 to 2.2 parts of clove, 0.2 to 2.2 parts of liquorice, 79 to 81 parts of edible sodium bicarbonate and 4 to 6 parts of corn starch; wherein: the stomach nourishing health care medicine is obtained by the following method: firstly, crushing long pepper, galangal, tangerine peel, fingered citron, wrinkled gianthyssop, cinnamon, clove and liquorice, sieving by a 100-mesh sieve, taking undersize materials, uniformly mixing to obtain eight-medicine mixture, performing cobalt-60 irradiation sterilization, and uniformly mixing the eight-medicine mixture and edible sodium bicarbonate to obtain a mixture; secondly, taking normal-temperature purified water with the mass of 1.5 times of that of the corn starch, dispersing the corn starch in the normal-temperature purified water, uniformly stirring, adding boiled purified water with the mass of 2.5 times of that of the corn starch, stirring while adding to form semitransparent starch paste, adding a mixture into the corn paste when the temperature of the corn paste is reduced to 55-60 ℃, and fully stirring and uniformly mixing to obtain a soft material which is held to be agglomerated and is pressed to be dispersed; thirdly, granulating by using a sieve with 14 meshes to 16 meshes to obtain granules, and then drying the granules until the water content of the granules is 2 percent to 3 percent to obtain dried granules; fourthly, firstly, granulating, then adding magnesium stearate accounting for 0.5 to 1 percent of the weight of the dried granules into the homogenized dried granules, uniformly mixing, and then tabletting to obtain the stomach-nourishing health-care medicine; in the first step, the absorbed dose of the cobalt-60 is less than or equal to 6KGy during radiation sterilization, and the radiation time is 24 hours; in the third step, drying the particles in a dry hot air circulating oven at 60-70 ℃ to obtain dry particles; in the fourth step, the homogenized dried granules were sized with a 14 mesh stainless steel mesh.
2. The stomach nourishing health medicine according to claim 1, characterized in that the raw materials comprise, by weight, 2.4 parts of long pepper, 2.4 parts of galangal, 2.4 parts of dried orange peel, 1.8 parts of fingered citron, 1.8 parts of wrinkled gianthyssop herb, 1.8 parts of cinnamon, 1.2 parts of clove, 1.2 parts of licorice, 80 parts of edible sodium bicarbonate and 5 parts of corn starch.
3. A method for preparing a stomach nourishing health care medicine according to claim 1 or 2, characterized by comprising the following steps: firstly, crushing long pepper, galangal, tangerine peel, fingered citron, wrinkled gianthyssop, cinnamon, clove and liquorice, sieving by a 100-mesh sieve, taking undersize materials, uniformly mixing to obtain eight-medicine mixture, performing cobalt-60 irradiation sterilization, and uniformly mixing the eight-medicine mixture and edible sodium bicarbonate to obtain a mixture; secondly, taking normal-temperature purified water with the mass of 1.5 times of that of the corn starch, dispersing the corn starch in the normal-temperature purified water, uniformly stirring, adding boiled purified water with the mass of 2.5 times of that of the corn starch, stirring while adding to form semitransparent starch paste, adding a mixture into the corn paste when the temperature of the corn paste is reduced to 55-60 ℃, and fully stirring and uniformly mixing to obtain a soft material which is held to be agglomerated and is pressed to be dispersed; thirdly, granulating by using a sieve with 14 meshes to 16 meshes to obtain granules, and then drying the granules until the water content of the granules is 2 percent to 3 percent to obtain dried granules; fourthly, firstly, granulating, then adding magnesium stearate accounting for 0.5 to 1 percent of the weight of the dried granules into the homogenized dried granules, uniformly mixing, and then tabletting to obtain the stomach-nourishing health-care medicine; wherein: in the first step, the absorbed dose of the cobalt-60 is less than or equal to 6KGy during radiation sterilization, and the radiation time is 24 hours; in the third step, drying the particles in a dry hot air circulating oven at 60-70 ℃ to obtain dry particles; in the fourth step, the homogenized dried granules were sized with a 14 mesh stainless steel mesh.
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| FR3115679A1 (en) * | 2020-11-02 | 2022-05-06 | Jean Angelidis | Natural composition for gastric treatment, in particular for the treatment of gastric ulcers, Associated manufacturing process and Application to equines |
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