CN102772781B - Traditional Chinese medicine preparation for treating chronic colitis and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating chronic colitis and a preparation method thereof. The traditional Chinese medicine preparation are prepared from the following medicinal raw materials in parts by weight: 10-20 parts of pasqueflower, 10-20 parts of yam, 10-20 parts of bletilla, 10-20 parts of baikal skullcap root, 10-20 parts of radix sophorae flavescentis, 10-20 parts of nutmeg, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of tuckahoe, 10-20 parts of garden burnet, 10-20 parts of bulbus allii macrostemi, 10-20 parts of pericarpium arecae, 10-20 parts of coptis, 10-20 parts of dried old orange peel, 10-20 parts of alum, 10-20 parts of bark of Chinese ash, 10-20 parts of focal divina commedia, 10-20 parts of fructus schizandrae, 10-20 parts of ginger and 10-20 parts of granatum. The traditional Chinese medicine preparation discloses by the invention has the functions of antidiarrheal and diminishing inflammation, resolving tetany and relieving pain, improving local blood circulation and metabolism, reinforcing the intestinal immune function and prompting the ulcer recovery. The traditional Chinese medicine preparation discloses by the invention is simple and convenient in preparation process, has small toxic and side effects, is conveniently applied, and is low in cost and easy to prepare. Furthermore, the traditional Chinese medicine preparation directly reaches the focus, so that the healing time is short, and the disease does not recur after being healed.

Description

A kind of Chinese medicine preparation for the treatment of chronic colitis and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine preparation for the treatment of chronic colitis and preparation method thereof.

Background technology

Chronic colitis is a kind of chronic, repeatability, multiple taking colon, sigmoid colon and rectum as site of pathological change.Refer to that rectum colon causes the inflammatory edema of intestinal, ulcer, hemorrhage pathological changes because of various pathogenesiss.Symptom be left lower quadrant pain, diarrhoea, tenesmus, time be just stained with down liquid, constipation or have loose bowels that alternately property occurs, bad when fashion, touching lower disconnected, outbreak repeatedly.Chronic colitis is that chronic colon is divided into specificity according to pathogenesis conventionally, has the colitis of obvious cause, and non-specific be the not clear colitis of pathogenesis.Chronic colitis onset is slow, does not sustainablely alleviate or movable and is staticly alternately chronic reaction.

Can there is constipation or the symptom of having loose bowels in patient, have that defecation frequency increases, difficult defecation, just lower a large amount of mucus or band blood, time have tenesmus phenomenon, follow left lower quadrant pain, be and have a dull ache, weight loss, becomes thin, lassitude.After conventional therapy medication, symptom can be eased, and symptom alleviates, easily recurrence after drug withdrawal.Chronic colitis cause of disease complexity, diagnosis is especially important, should do a series of inspections.Inspection can help doctor to get rid of other can to cause the disease of similar symptom, such as Crohn disease, and irritable bowel syndrome person diverticulitis.

Comprising that in a series of inspections of blood examination, excrement inspection, colonoscopy is even more important.Chronic colitis must be passed through the splanchnoscopy ability different range of clear and definite inflammation and the degree of pathological changes, thereby clarifies a diagnosis.Chronic colon is followed the trail of after inspection by pathologic finding and continuous regular endoscope, constantly adjusts therapeutic scheme, just can make colitis obtain reasonably effectively treating.Olympus electronics Overall Colonoscope advantage: integrate inspection, diagnosis and treatment function, clear picture, the exquisite depth of field of camera lens is large, can observe directly people's ascending colon, transverse colon, colon descendens intestinal mucosa pathological changes, neoplastic lesion, inspection to early stage colon cancer accurately checks, its another critical function is: can carry out treating under mirror to polyp of colon.

Chronic colitis is a kind of chronic, repeatability, multiple taking colon, sigmoid colon and rectum as site of pathological change.Symptom be left lower quadrant pain, diarrhoea, tenesmus, time be just stained with down liquid, constipation or have loose bowels that alternately property occurs, bad when fashion, touching lower disconnected, outbreak repeatedly.One, irritated factor: anaphylaxis pathological changes, is affected by individual variation.Be mainly intestinal allergy, also time, have the skin of involving.Some people produces irritated to the high protein diet such as Fish, shrimp, Eriocheir sinensis, Lac Bovis seu Bubali, these are all foreign protein a large amount of histamines materials that produces while entering human body, initiation anaphylactic reaction.Anaphylactic reaction, is stimulated by sensitizer, and autoimmune induces reaction, and discharges self-defence material and excites the cohesion of a large amount of immunocytes, all concentrates on gastrointestinal mucosal surface, thereby cause that the inflammation such as the hyperemia of mucomembranous surface edema and sepage occur.Anaphylactic reaction is the change along with human lives, dietary habit, and individual difference is the irritated principal element of digestion.Two, infective agent: infect, be one of Etiological in the colitis cause of disease.Although fail to examine pathogenic bacterium, virus or fungus in feces.In the time of morbidity, use antibiotic to have and control in various degree the state of an illness and therapeutic effect, this explanation antibiotic has the escherichia coli of inhibition and other pathogenic bacterium, can lower clinical symptoms, it is generally acknowledged all relevant with infection.The mankind are heterophagous, do not tie or rotten food when having eaten, and tend to occur intestinal pathological changes, are to account for colitis cause of disease majority.Three, autoimmune: along with social development, the progress of medical science, immunologic Fast Growth, have a lot of not clear causes of disease all to verify.At present, the sickness rate of immune disease is high, and treatment difficulty, draws attention.Therefore, chronic colitis is difficult to cure under conventional therapy is.

Patients with chronic colitis often has the symptoms such as diarrhoea, stomachache, abdominal distention, dyspepsia.Chinese medicine thinks that chronic colitis " diarrhoea " belongs to " chronic diarrhea " category, mainly due to insufficiency of the spleen and lose due to normal transportation capabilities.If the fluctuation person that needs defecation that is in a bad mood, is " hyperactive liver-QI attacking the spleen "; And the person that all needs defecation early morning every day is " asthenia of both the spleen and kidney ".In treatment, need to take respectively the method for warm spleen invigorating sun, soothing liver and strengthening spleen and warming and recuperating the spleen and kidney, assistant is with relieving diarrhea with astringents medicine, and treating both the principal and secondary aspects of a disease, often can obtain good curative effect.But in therapeutic process, patient also needs " dieting ".Because the raising of " dieting " and therapeutic effect and consolidate close relation, though otherwise medicine suit the medicine to the illness, therapeutic effect is not good, even makes a futile effort; Or be improved, see again Relapse rate, so that all that has been achieved is spoiled.

Summary of the invention

Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, new drug with low cost.The present invention is Chinese medicine preparation, can reach antidiarrheal antiinflammatory, relieving spasm to stop pain, improves local blood circulation and metabolism, enhancing intestinal immunity, promote the object of ulcer healing.The present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, and safety, and toxic and side effects is little, and preparation is simple, the focus of going directly, and healing time is short, after curing, is difficult for recurrence.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of chronic colitis, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: 10～20 parts of the Radix Pulsatillaes, 10～20 parts of Rhizoma Dioscoreaes, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Semen Myristicaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts, Poria, 10～20 parts of Radix Sanguisorbaes, 10～20 parts of Bulbus Allii Macrostemonis, 10～20 parts of Pericarpium Arecae, 10～20 parts of Rhizoma Coptidis, 10～20 parts of Pericarpium Citri Reticulataes, 10～20 parts of Alumens, 10～20 parts of Cortex Fraxinis, 10～20 parts of Massa Medicata Fermentata (parched to brown), 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts, Rhizoma Zingiberis Recens, 10～20 parts of Pericarpium Granatis.

The Chinese medicine preparation of described treatment chronic colitis, in described Chinese medicine preparation, the ratio of weight and number of various crude drug can also be: 10～15 parts of the Radix Pulsatillaes, 10～15 parts of Rhizoma Dioscoreaes, 10～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Sophorae Flavescentiss, 10～15 parts of Semen Myristicaes, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts, Poria, 10～20 parts of Radix Sanguisorbaes, 10～20 parts of Bulbus Allii Macrostemonis, 10～20 parts of Pericarpium Arecae, 10～20 parts of Rhizoma Coptidis, 10～20 parts of Pericarpium Citri Reticulataes, 10～20 parts of Alumens, 10～20 parts of Cortex Fraxinis, 10～20 parts of Massa Medicata Fermentata (parched to brown), 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts, Rhizoma Zingiberis Recens, 10～20 parts of Pericarpium Granatis.

The Chinese medicine preparation of described treatment chronic colitis, in described Chinese medicine preparation, the ratio of weight and number of various crude drug can be also: 10～20 parts of the Radix Pulsatillaes, 10～20 parts of Rhizoma Dioscoreaes, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Semen Myristicaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts, Poria, 10～15 parts of Radix Sanguisorbaes, 10～15 parts of Bulbus Allii Macrostemonis, 10～15 parts of Pericarpium Arecae, 10～15 parts of Rhizoma Coptidis, 10～15 parts of Pericarpium Citri Reticulataes, 10～15 parts of Alumens, 10～15 parts of Cortex Fraxinis, 10～15 parts of Massa Medicata Fermentata (parched to brown), 10～15 parts of Fructus Schisandrae Chinensis, 10～15 parts, Rhizoma Zingiberis Recens, 10～20 parts of Pericarpium Granatis.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine preparation for the treatment of chronic colitis, and the preparation method that the dosage form of described Chinese medicine preparation is capsule comprises:

A, getting crude drug and add water extraction 2 times, become extractum shape, is component 1;

It is extractum shape that b, medicinal residues add ethanol thickening filtration, is component 2;

C, above-mentioned two kinds of extractum concentrate dryings are become to dry cream, co-grinding, fill capsule.

In described step a, can get the water soaking 1-2 hour that crude drug adds 5-10 doubly to measure, extract 2 times; Heating extraction 1-2 hour, is concentrated into extractum shape, becomes component 1.

In described step b, medicinal residues can be added to 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid,, filter, concentrated, 80-160 order filters, the 6000-10000 rev/min of supernatant after centrifugal, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, 1.35 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating and refluxing extraction 2 times, each 30 minutes～45 minutes, extract active ingredient, 2 extracting solution are merged and are settled into extractum shape, as component 2.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine preparation for the treatment of chronic colitis, and the preparation method that described Chinese medicine preparation dosage form is enema comprises:

Described crude drug is soaked 30 minutes to 1 hour, and heated and boiled 30～40 minutes, filters, and filtrate is for subsequent use; Filtering residue adds water and heats for the second time, boils 30～40 minutes, filters, and filtrate is for subsequent use; Filtering residue adds water again, and heated and boiled 30～40 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into pasty state medicinal liquid.

The using method of described enema is: when use, get above-mentioned enema 100mL～200mL at every turn, retention enema, pour into 30mL～50mL at every turn, slowly inject with No. 12 oxygen catheters and 50mL syringe, insertion depth is 15cm～20cm, and 2～3 times/d, 20min is at least adhered in each requirement, the coloclysis time, fluid temperature and human body temperature were adapted to suitable taking sooner or later as good; 10d is 1 basic course for the treatment of.

For solving the problems of the technologies described above, the present invention also provides a kind of dosage form of Chinese medicine preparation for the treatment of chronic colitis, comprising: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder, enema or patch.

For solving the problems of the technologies described above, the present invention also provides a kind of using method of Chinese medicine preparation for the treatment of chronic colitis, and medicine is decocted in use decoction and taken, and 1 dose of every day, decocting takes at twice, and every 7 days is a course for the treatment of; When this Chinese medicine preparation is pill, capsule or tablet while using, three times on the one, every 7 days is a course for the treatment of; After drug decocting, make enema, or make patch and stick abdominal part or umbilicus place, 10d is 1 basic course for the treatment of.

Umbilicus, cave name Shenque, for the important acupuncture point of conception vessel, Gu has saying of " Shenque, curing mainly all kinds of diseases and ailments, and old man, empty people have loose bowels as god ", position, umbilicus place is again that chong channel is through row part, Conception Vessel and Governor Vessel is the exterior and the interior each other, and commander's human body is all through hundred arteries and veins, therefore umbilical part is by above meridians and all internal organs organ close ties of whole body.Human body stomach wall is thin, and local application is easy to absorb, and no pain, and external application of Chinese medicine Shenque can reach dispelling cold and activating YANG, regulating QI to relieve pain, rapidly the merit of dysentery relieving disease.

Chinese medicine preparation of the present invention has effect of suppressing the hyperactive liver pain relieving, regulating qi-flowing for strengthening spleen, spleen reinforcing lung kidney, invigorating the spleen and replenishing QI and yang invigorating antidiarrheal, cures mainly taste uncomfortable, and weakness of the spleen and stomach.The present invention can reach antidiarrheal antiinflammatory, relieving spasm to stop pain, improve local blood circulation and metabolism, enhancing intestinal immunity, promote the object of ulcer healing.Processing technology of the present invention is easy, and toxic and side effects is little, and convenient drug administration, and medicament is easy to manufacture, with low cost.And the focus of going directly, healing time is short, non-relapse after healing.

Detailed description of the invention

Chronic colitis belongs to the categories such as the warm dysentery, hemorrhoidal hamorrhage, dysentery, abscess of internal organ of motherland's medical science.The traditional Chinese medical science thinks because individual natural endowment is not enough or by the exopathogen impairment of the spleen, damp-heat accumulation, and coagulation of QI-blood due to dysfunction of the spleen in transportation, turbid damp internal resistance etc. is stopped up and is that pus is the stasis of blood, causes the symptoms such as stomachache, red white dysentery, burning sensation of the anus, tenesmus.

Chronic colitis and taste are closely related, and rectum and sigmoid colon are involved in sick position more, adopt herbal retention enema method, make the medicine sick institute that go directly, and the while can also be cleaned by local douche, meets the treatment principle to chronic noninfective inflammation.The present invention can reach antidiarrheal antiinflammatory, relieving spasm to stop pain, improve local blood circulation and metabolism, enhancing intestinal immunity, promote the object of ulcer healing.

When adopting herbal retention enema, coordinate famotidine and intestinal spasmolytic Anisodamine, curative effect is better.The main cause of diarrhoea, is mainly being invaded by exogenous pathogen, internal injury diet, weakness of the spleen and stomach etc., and its pathological changes is at taste, and because of the main digesting food of stomach, it is precise and tiny that The spleen has the function to transport and transform nutrients, if taste are subject to disease, diet enters stomach, indigestion, and abnormal ascent-descent between clear YANG and turbid YIN, and walk large intestine, then become to have loose bowels.The a large amount of antibiotic of prolonged application cause dysbacteriosis also can cause bacterial diarrhea.Patients with chronic colitis often has the symptoms such as diarrhoea, stomachache, abdominal distention, dyspepsia.Chinese medicine thinks that chronic colitis " diarrhoea " belongs to " chronic diarrhea " category, mainly due to insufficiency of the spleen and lose due to normal transportation capabilities.If the fluctuation person that needs defecation that is in a bad mood, is " hyperactive liver-QI attacking the spleen "; And the person that all needs defecation early morning every day is " asthenia of both the spleen and kidney ".In treatment, need to take respectively the method for warm spleen invigorating sun, soothing liver and strengthening spleen and warming and recuperating the spleen and kidney, assistant is with relieving diarrhea with astringents medicine, and treating both the principal and secondary aspects of a disease, often can obtain good curative effect.But in therapeutic process, patient also needs " dieting ".Because the raising of " dieting " and therapeutic effect and consolidate close relation, though otherwise medicine suit the medicine to the illness, therapeutic effect is not good, even makes a futile effort; Or be improved, see again Relapse rate, so that all that has been achieved is spoiled.

Rhizoma Coptidis, Radix Scutellariae, Radix Sophorae Flavescentis nature and flavor bitter cold that the present invention adopts, share can be clearly in, damp-heat in lower-JIAO, there is the effect of heat clearing and damp drying, eliminating fire and detoxication.The Pseudobulbus Bletillae (Rhizoma Bletillae), because of containing colloid, is apt to detumescence, granulation promoting, is distributed in mucosa face, can protect mucosa, and short its regeneration, has the merit that promotes ulcer healing.Rhizoma Atractylodis Macrocephalae nourishing the stomach relieving spasm to stop pain.The heat that the Radix Pulsatillae can purify the blood point is the key medicine of pyretic toxicity bloody dysentery.Alumen has effect of astringing to arrest bleeding, relieving diarrhea with astringents.Cortex Fraxini, Radix Sanguisorbae return large intestine channel, and removing pathogenic heat from blood and toxic substance from the body can stop pus and blood.Semen Myristicae osmanthus is warm in nature, effect using corrigent, the anti-cold and cool yang-energy that too damages, Rhizoma Dioscoreae coordinating the actions of various ingredients in a prescription, the intestine moistening of Pericarpium Granati antidiarrheal, Bulbus Allii Macrostemonis, the excited gastrointestinal smooth muscle of Pericarpium Arecae, short digestive tract power effect; Pericarpium Citri Reticulatae, Massa Medicata Fermentata (parched to brown) and Fructus Schisandrae Chinensis have spleen invigorating, the drying dampness to eliminate phlegm of ventilation; Effect of the greasy lasting of Rhizoma Zingiberis Recens solution, stopping nausea and vomiting by lowering the adverse flow of QI.

Radix Pulsatillae bitter in the mouth, cold in nature; Return stomach, large intestine channel; There is heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, effect of removing dampness and killing parasites; Cure mainly pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, the scrofula Radix Pulsatillae is the key medicine of controlling amebic dysentery, alone larger dose, produces effect.Commonly use into square Radix Pulsatillae Decoction, taking this product as principal agent, coordinate Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini to form, both can be with having controlled amebic dysentery, also can be with controlling bacillary dysentery." book on Chinese herbal medicine justice " carries it: Radix Pulsatillae mildly bitter flavor and light, and the clear light weight of gas, " herbal classic " though the bitter temperature of meaning is so mad easily to cure mainly pyrexial malaria, and Zhong Jing and specially to control diarrhea of heat type with tenesmus, Bi Feiwen medicine is known.Its main pyretic toxicity dysentery, admittedly can let out, and elevate a turnable ladder taste clearing heat in QI system makes not sag though say hardship, and tenesmus all removes, really the tangible true essence of this medicine.

Bulbus Allii Macrostemonis is pungent, bitter, temperature.Return lung, stomach, large intestine channel.Regulate the flow of vital energy, the chest stuffiness relieving, activates yang, eliminating stagnation.Control the thorough back of the body of obstruction of qi in the chest and cardialgia, gastral cavity painful abdominal mass is not relaxed, and retches, heavy after dysentery, furuncle.Activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.For thoracic obstruction pain, phlegm retention cough with asthma, lets out after dysentery heavy.Supplement to the Herbal carries it: in tune, main chronic diarrhea is not recovered, normal evil person in large abdomen, but cook it more.

Pericarpium Arecae (former plant latin name: Areca catechu L.) is the dry peel of babassu Semen Arecae.Have another name called Semen Arecae clothing.Main product in Hainan, the ground such as Guangxi, Yunnan.Winter to time spring green fruit of gathering, boils rear dryly, and vertical profile two lobes, strip peel, practise and claim " Pericarpium Arecae "; The mature fruit of gathering at the beginning of spring end to autumn, boils rear dryly, strips peel, beats pine, dries, and practises and claims " PERICARPIUM ARECAE ", raw use.There is therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, effect of line water detumescence.Modern study, these product have excited gastrointestinal smooth muscle, short digestive tract power effect, and have the effects such as the fibrinolysis of promotion.Acrid in the mouth; Slightly warm in nature.Return spleen; Stomach; Large intestine; Small intestine meridian.Modern study, these product have excited gastrointestinal smooth muscle, short digestive tract power effect, and have the effects such as the fibrinolysis of promotion." Kaibao Bencao ": the main cold and hot gas abdomen of making a psychological attack, large intestine is stopped up poison, expectorant diaphragm, the belching of acid from stomach.And decoct with Jiang Yantong, enter to dredge gas medicine good." detailed outline ": lowering the adverse flow of QI, aqueous vapor edema in the skin that disappears, beriberi is stopped up contrary, subtertian malaria feeling of fullness, nausea malignant histocytosis feeling of distension and oppression." book on Chinese herbal medicine is new again ": eliminating the pathogens from the lung, easing stomach-QI, dampness removing chases after wind, wide intestinal detumescence, reason waist beriberi, treating malaria disease dysentery.

Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually damp and hot middle resistance, feeling of fullness vomiting for cold and heat.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.The diseases such as, vomiting damp and hot for retention of damp-heat in the interior, the intestines and stomach, dysentery.Join Radix Scutellariae, Radix Et Rhizoma Rhei etc., can control the card of retention of damp-heat in the interior.To the damp and hot the intestines and stomach of being reluctant to leave, often coordinate the Rhizoma Pinelliae, Caulis Bambusae In Taenia; Join the Radix Aucklandiae, Radix Scutellariae, Radix Puerariae etc. to control dysentery.

Fructus Schisandrae Chinensis temperature; Sour, sweet; Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.Fruit is made Chinese medicine function supplementing QI for promoting the production of body fluid, the nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, is calmed the nerves, and can control the diseases such as chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, seminal emission chronic diarrhea, forgetful insomnia.Schisandra fruit implementation Chinese medicine function supplementing QI for promoting the production of body fluid, the nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, calm the nerves, can control the diseases such as chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, seminal emission chronic diarrhea, forgetful insomnia.Pharmacological testing proves to regulate central nervous system's excitement and process of inhibition, promotes body metabolism, regulates gastric juice and bile secretion, and hepatitis convalescent period transaminase rising person is had to reducing effect." book on Chinese herbal medicine converges and says ": Fructus Schisandrae Chinensis, the medicine that astringing QI promotes the production of body fluid also.Therefore the gas of the main convergence deficiency of the lung of Tang Materia Medica chronic cough dissipation.All deficiency of vital energy dyspnea with rapid respiration, cough with dyspnea strain, spirit is not enough, arteries and veins gesture inanition, or impairment caused by overstrain yang-energy, limbs are won thin, or empty gas is superior, and spontaneous perspiration comes frequently, or smart first exhaustion, and deficiency of YIN fire is scorching, or exhaustion of YIN YANG-depletion, refreshing scattered pulse is de-, controls it with Fructus Schisandrae Chinensis, and its acid of salty use is held back and is promoted the production of body fluid, and protects reinforcing premodial qi and without spermatorrhea also.So upper enter lung, be lowered to kidney, entering lung has the benefit of the Jiyuan of promoting the production of body fluid, entering kidney has controlling nocturnal emission with astringent drugs to support the merit of marrow.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." property of medicine opinion " carries it: monarch, and sweet in the mouth, pungent, nontoxic.The main large migratory arthralgia of energy, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, under stopping, lets out.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in abdomen is vomited and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.

Rhizoma Dioscoreae sweet in the mouth, property are put down, and enter lung, spleen, kidney channel; Not dry oiliness, there are strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, grow that will is calmed the nerves, effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red disease such as swollen, fat of the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.Compendium of Material Medica is summarized five large functions " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, the saliva that reduces phlegm, profit skin ".Rhizoma Dioscoreae is cooked congee or simmers after ripe and take with crystal sugar, and, colitis poor to health, deficiency of the kidney chronic diseases are all effective in cure.Strengthen the spleen and stomach: treatment weakness of the spleen and stomach, have loose bowels, body is tired, lack of appetite, sweating due to debility.Lung benefiting nourishing kidney: this product is cold not dry, sweet in the mouth matter profit, can treat lung suffer from a deficiency of the kidney damage quench one's thirst, pass out semen, be with inferior disease.Be described as angle's medicine.

Pericarpium Citri Reticulatae temperature; Pungent, bitter; The bitter substance of returning spleen, lung meridian Pericarpium Citri Reticulatae is taking limonin and bitter principle as representative " limonoid ", and this limonoid taste is gentle, soluble in water, contributes to the digestion of food.When Pericarpium Citri Reticulatae is used for cooking dishes.Its bitterness and other tastes are in harmonious proportion mutually, can form original in style local flavor.Pericarpium Citri Reticulatae contains the compositions such as volatile oil, hesperidin, vitamin B, C, and its contained volatile oil has gentle stimulation to gastrointestinal tract, and pneumatosis in intestinal tube is got rid of in secretion that can facilitating digestion liquid, increases appetite.Pericarpium Citri Reticulatae is also conventional Chinese medicine simply, has the greasy lasting of spleen invigorating, drying dampness to eliminate phlegm, solution of ventilation, effect of stopping nausea and vomiting by lowering the adverse flow of QI.

Semen Myristicae astringent medicinal; Drugs for dispelling internal cold; Qi-activating drug.The pungent bitter in the mouth of property, temperature.Return spleen; Stomach; Large intestine channel.Effect warming middle-JIAO astringing intestine to stop diarrhea; Promote qi circulation digestion promoting.For diarrhea of deficiency type; Cold-dysentery; Abdominal distention; Lack of appetite vomiting; Dyspepsia does not disappear." Japan hanako materia medica ": in tune, the therapeutic method to keep the adverse QI flowing downwards, antidiarrheal dysentery, appetizing, helps digestion.The outer network of skin, the therapeutic method to keep the adverse QI flowing downwards, alcoholic intoxication, controls cholera." Kaibao Bencao ": warming middle-JIAO, control accumulation of pathogenic cold trusted subordinate distending pain, cholera attacked by pestiferous factors, spitting saliva, cold air, the stopping leak that helps digestion, children's's breast is suddenly." detailed outline ": warming the spleen and stomach, Gu large intestine.

Pericarpium Granati has relieving diarrhea with astringents, hemostasis, effect of anthelmintic." property of medicine opinion " carries it: " control muscles and bones wind, waist foot is unsuccessful, the anxious pain of walking contraction.Main astringing intestine to stop diarrhea, stops red white dysentery.Extracting juice stops under order tear, controls Lou essence." supplement to the Herbal carries it: " main ascarid.Decoction." " the southern regions of the Yunnan Province book on Chinese herbal medicine " carries it: " controls with the passing of time watery diarrhea, simmers clothes with frying Saccharum Sinensis Roxb., controls again dysentery pus and blood, large intestine hematochezia.＂ ＂ decocts and controls children's's infantile malnutrition worm with Fructus Aristolochiae." experiment in vitro shows: Pericarpium Granati is to escherichia coli, bacterium sonnei, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, 7 kinds of Grain-negative enteral pathogenic bacterium such as vibrio cholera all have inhibitory action. in vitro, Pericarpium Granati decoct all has antibacterial action to 4 kinds of dysentery bacteriums, but difference to some extent in degree, with to the strongest (1:320) of shigella effect, to Amur, bacterium flexneri take second place (1:80), and to bacterium sonnei effect poor (1:20). the antibacterial effect of flat band method is lower than test tube method. and its antibacterial action mechanism is relevant with its contained volume tannic acid

Massa Medicata Fermentata is the processed goods forming through fermentation after whole wheat flour and other drug (Herba Artemisiae Annuae, Herba Xanthii, the buds such as Herba polygoni hydropiperis, Semen Armeniacae Amarum, Semen Phaseoli) mixing.Get Massa Medicata Fermentata and put in pot, to fry to appearance and be coke black, inner coke yellow, take out, spray the water that disappears, cool, be Massa Medicata Fermentata (parched to brown).Massa Medicata Fermentata forms through fermentation, and the product of all fermentations have the digestant effect of strengthening the spleen and stomach, therefore, quite has effect for bad, the feeling of stuffiness in chest abdominal distention of the digestion due to diet internal injury.

Poria is sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Function promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful." herbal classic " carries it: " the contrary gas of the main breast side of body, melancholy is angerd frightened heresy and probably throbbed with fear, knot pain under the heart, cold and heat stuffy sensation with restlessness, cough with dyspnea, mouthful burnt dry tongue, diuresis." " not Lu ": " only quenches one's thirst, likes to sleep, and large abdomen, drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema is drenched knot.Open breast internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, physical strength profiting, during guarantor god keeps." " property of medicine opinion ": " appetizing, preventing or arresting vomiting is contrary, kind tranquilizing mind.Main consumptive lung disease expectorant is stopped up.Control pediatric epilepsy scared, trusted subordinate's distension, married woman's pyretic stranguria."

Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.1. anastalsis: Pseudobulbus Bletillae (Rhizoma Bletillae) can strengthen platelet factor III activity, significantly shortens clotting time and thrombinogen formation time, suppresses plasmin enzymatic activity, and local hemorrhage is had to anastalsis; Zoopery shows, external haemostatic effect is quite good to parenchymatous organ's (liver, spleen), muscle vascular be hemorrhage etc. for Pseudobulbus Bletillae (Rhizoma Bletillae) water extraction.2. protection gastric mucosa: 1% Pseudobulbus Bletillae (Rhizoma Bletillae) decoct gavage, the rat pipe film injury that hydrochloric acid is caused has protective effect; To anesthetized dog, experimental Stomach duodenum perforation has therapeutical effect.3. antibacterial, antifungic action: the immersion of Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol has inhibitory action to staphylococcus aureus, bacillus subtilis, Bacillus tuberculosis; Water logging agent has inhibitory action to microsporon audouini; Contained 3 biphenyl classes and 2 the luxuriant and rich with fragrance compounds of two hydrogen of Pseudobulbus Bletillae (Rhizoma Bletillae) have inhibitory action to staphylococcus aureus, bacillus subtilis, Candida albicans ATCC 1057 and Trichophyton QM 248.

Radix Sanguisorbae property of medicine picric acid; Cold; Nontoxic, return liver; Lung; Kidney; Large intestine channel, effect cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.Effect classification hemorrhage; Blood-cooling hemostatic.Cure mainly haematemesis, spitting of blood, epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting." detailed outline ": Radix Sanguisorbae, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat, control defecation blood disorder.Hemostasis, gets and cuts off sheet and fry use, and its tip can promoting the circulation of blood, can not know.Yang Shiying cloud: all skin ulcer pain persons add Radix Sanguisorbae, and the person of itching adds Radix Scutellariae.

Alumen nature and flavor are sour and astringent, cold, poisonous.Therefore have antibacterial action, astriction etc., can be used as Chinese medicine.Alumen also can be used for preparing aluminum salt, yeast powder, paint, tanning material, clarifier, mordant, papermaking, waterproofing agent etc.Alumen sour-puckery flavor cold in nature, has stronger astriction, and the traditional Chinese medical science thinks that Alumen has removing toxic substances parasite killing, dampness removing to stop itchin, hemostasis antidiarrheal, effect of heat clearing away expectorant.Studies confirm that in recent years, Alumen also has the effects such as antibacterial, anti-trichomonas vaginitis.In some, medical Alumen is treated the diseases such as hyperlipemia, duodenal ulcer, hemoptysis of pulmonary tuberculosis.

Cortex Fraxini English name: CORTEX FRAXINI Latin plant animal mineral name: Fraxinus rhynchophylla Hance F.Chinensis Roxb.var.rhynchopylla (Hance) Hemsl.] and nature and flavor hardship, cold.Heat clearing and damp drying Chinese medicine.Cure mainly: heat clearing and damp drying, liver heat removing and eyesight improving, antiasthmatic-antitussive.For pyretic toxicity dysentery, conjunctival congestion and swelling pain, the raw cataracta of order.Antibacterial action: Cortex Fraxini decoct pastille flat band method, 1:50 is to staphylococcus aureus, dysentery bacterium, 1:20 has inhibitory action to escherichia coli etc. and in vitro tests shows, Cortex Fraxini is inhibited to various bacteria such as staphylococcus epidermidis, micrococcus catarrhalis, bacillus pyocyaneus. anti-inflammatory and analgesic effect: eaculin has inhibitory action to experimental arthritis, and have faint analgesic activity.

Rhizoma Zingiberis Recens is warm in nature, its distinctive " gingerol " can stimulating gastrointestinal mucosa, make gastrointestinal tract hyperemia, digestion power strengthens, and can effectively treat the abdominal distention of eating cold and cool food and too much causing, stomachache, diarrhoea, vomiting etc.Ate after Rhizoma Zingiberis Recens, people has the sensation of health heating, and this is because it can distend the blood vessels, and blood circulation is accelerated, and impels pore with it to open, and so not only the unnecessary torrid zone can be walked, and also the pathogenic bacteria in body, cold is together taken out of simultaneously.Eat cold and cool thing when health, be subject to drench with rain or in air-conditioned room, stayed long afterwards, eaten Rhizoma Zingiberis Recens and just can eliminate in time because of the cold various discomforts that remake of human body.For the pungent stomachic of armaticity, there are the effects such as warm, excited, diaphoresis, preventing or arresting vomiting, removing toxic substances, warming the lung to relieve cough, especially for fish Eriocheir sinensis poison, the drug intoxication such as the Rhizoma Pinelliae, Rhizoma Arisaematis have Detoxication.Be applicable to affection of exogenous wind-cold, headache, phlegm retention, cough, gastrofrigid vomiting; Suffering, after ice and snow, wet, the cold invasion and attack of water, suddenly to drink it with ginger decoction, can promote blood, disperse cold-evil.

Radix Sophorae Flavescentis hardship, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, dermatomycosis, eczema, skin pruritus, scabies leprosy.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestinal profit and water from by, source is clearly flowed also clean.The blood person of closing, excess-heat is at blood system, and amenorrhea is made us obstructed in instant heating human blood chamber, damp and hot solution, Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is stayed knot, and is that carbuncle stain is also rotten: acute scleritis person, fire of moxibustion blood trouble also, removing heat from blood heat extraction, spontaneous recovery also.Radix Scutellariae has antiallergic action and antiinflammatory action: the contained baicalin of Radix Scutellariae and baicalin can obviously suppress the anaphylaxis contractile response that sensitized guinea pig rat small intestine in vitro and isolated tracheal produce antigen, passive general allergy to Cavia porcellus and mice and Cavia porcellus passivity skin allergic reaction, baicalin and baicalin also have inhibitory action.Radix Scutellariae has refrigeration function, most evidences, and the active ingredient baicaligenin of Radix Scutellariae has refrigeration function.Radix Scutellariae has Detoxication, and baicalin has obvious Detoxication, and this may be that baicalin decomposites glucuronic acid due under the effect of glucuronidase, and due to being combined with multiple poisonous substance.10 milligrams of LD50 that can improve strychnine of baicalin reach 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mice is increased.

The manufacturing process of the present invention's honey refining pill is: get Radix Pulsatillae 1000g, Rhizoma Dioscoreae 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Radix Scutellariae 1000g, Radix Sophorae Flavescentis 1000g, Semen Myristicae 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Poria 1000g, Radix Sanguisorbae 1000g, Bulbus Allii Macrostemonis 1000g, Pericarpium Arecae 1000g, Rhizoma Coptidis 1000g, Pericarpium Citri Reticulatae 1000g, Alumen 1000g, Cortex Fraxini 1000g, Massa Medicata Fermentata (parched to brown) 1000g, Fructus Schisandrae Chinensis 1000g, Rhizoma Zingiberis Recens 1000g, Pericarpium Granati 1000g.

Medical material is soaked 30 minutes to 1 hour, and heated and boiled 30 minutes, filters, and filtrate is for subsequent use; Filtering residue adds water, and heating, boils 30 minutes for the second time, refilters, and filtrate is for subsequent use; Filtering residue adds water again, and heated and boiled 30 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 DEG C, is cooled to be Powderedly twisted into slice together with being mixed in right amount with Mel after oven dry; Pack taking every 5g as a ball wax seal.

The manufacturing process of capsule of the present invention is: get Radix Pulsatillae 1000g, Rhizoma Dioscoreae 1200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Radix Scutellariae 1000g, Radix Sophorae Flavescentis 1000g, Semen Myristicae 1300g, Rhizoma Atractylodis Macrocephalae 1000g, Poria 1500g, Radix Sanguisorbae 1000g, Bulbus Allii Macrostemonis 1000g, Pericarpium Arecae 1200g, Rhizoma Coptidis 1000g, Pericarpium Citri Reticulatae 1000g, Alumen 1000g, Cortex Fraxini 1000g, Massa Medicata Fermentata (parched to brown) 1000g, Fructus Schisandrae Chinensis 1200g, Rhizoma Zingiberis Recens 1000g, the water soaking 1-2 hour that Pericarpium Granati 1000g adds 5-10 doubly to measure, extracts 2 times; Heating extraction 1-2 hour, is concentrated into extractum shape, becomes component 1; Residue medicinal residues add 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid,, filters, concentrated, 80-160 order filters, and the 6000-10000 rev/min of supernatant after centrifugal, is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure relative density is the extractum of 1.35 (80 DEG C), heating and refluxing extraction 2 times, each 30 minutes～45 minutes, extracts active ingredient, 2 extracting solution are merged and are settled into extractum shape, as component 2.Above-mentioned two kinds of extractum concentrate dryings are become to dry cream, and co-grinding, adds dextrin appropriate, mixes fill capsule

Method for preparing tablet thereof of the present invention: get Radix Pulsatillae 1500g, Rhizoma Dioscoreae 1500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Radix Scutellariae 1500g, Radix Sophorae Flavescentis 1500g, Semen Myristicae 1300g, Rhizoma Atractylodis Macrocephalae 1500g, Poria 1500g, Radix Sanguisorbae 1500g, Bulbus Allii Macrostemonis 1200g, Pericarpium Arecae 1500g, Rhizoma Coptidis 1500g, Pericarpium Citri Reticulatae 1200g, Alumen 1200g, Cortex Fraxini 1200g, Massa Medicata Fermentata (parched to brown) 1500g, Fructus Schisandrae Chinensis 1500g, Rhizoma Zingiberis Recens 1500g, Pericarpium Granati 1500g, first puts into medical material 10 times of amount ethanol, heating and refluxing extraction 2 times, each 45 minutes, extract active ingredient, 2 extracting solution are merged and left standstill.Medicinal residues are added to 10 times of water gagings, heating and refluxing extraction 3 times, each 1 hour, merges 3 extracting solution again; Merge above-mentioned two kinds of extracting solution, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.06 (20 DEG C); The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicinal liquid; Add starch to be pressed into tablet.

The preparation method of enema of the present invention: get Radix Pulsatillae 1300g, Rhizoma Dioscoreae 1500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Radix Scutellariae 1500g, Radix Sophorae Flavescentis 1500g, Semen Myristicae 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Poria 1500g, Radix Sanguisorbae 1400g, Bulbus Allii Macrostemonis 1500g, Pericarpium Arecae 1500g, Rhizoma Coptidis 1100g, Pericarpium Citri Reticulatae 1500g, Alumen 1500g, Cortex Fraxini 1200g, Massa Medicata Fermentata (parched to brown) 1500g, Fructus Schisandrae Chinensis 1500g, Rhizoma Zingiberis Recens 1500g, Pericarpium Granati 1500g, soaks each crude drug in described medicine 30 minutes to 1 hour heated and boiled 30～40 minutes, filter, filtrate is for subsequent use; Filtering residue adds water and heats for the second time, boils 30～40 minutes, filters, and filtrate is for subsequent use; Filtering residue adds water again, and heated and boiled 30～40 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into pasty state medicinal liquid; Extracting juice 100mL～200mL, retention enema pours into 30mL～50mL at every turn, slowly injects with No. 12 oxygen catheters and 50mL syringe, retains medicinal liquid and is advisable with 10min, and insertion depth is 15cm～20cm, and 1d2 time, 4d was 1 course for the treatment of; Or make patch and stick abdominal part or umbilicus place.Umbilicus, cave name Shenque, for the important acupuncture point of conception vessel, Gu has saying of " Shenque, curing mainly all kinds of diseases and ailments, and old man, empty people have loose bowels as god ", position, umbilicus place is again that chong channel is through row part, Conception Vessel and Governor Vessel is the exterior and the interior each other, and commander's human body is all through hundred arteries and veins, therefore umbilical part is by above meridians and all internal organs organ close ties of whole body.Children's's skin is tender, and stomach wall is thin, and local application is easy to absorb, and no pain, and external application of Chinese medicine Shenque can reach dispelling cold and activating YANG, regulating QI to relieve pain, rapidly the merit of dysentery relieving disease.

Pharmacology pharmacodynamic experiment:

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: the Traditional Chinese medicine preparation capsule agent of the present invention of mice oral administration gavage, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, about 1 hour, recover normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight gain all normal, and experimental result shows: the maximum dosage-feeding of mice oral administration gavage Traditional Chinese medicine preparation capsule agent of the present invention is 488.8g crude drug/kg/d (LD50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; Press weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is clinical patient 4888 times.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select SD rat, give the Chinese medicine preparation pill of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, and after administration, the index checkings such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology are carried out in 90 days and drug withdrawal for 2 weeks.Result of the test shows: preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and matched group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range, between group without significant difference; Each group main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.

3, animal local excitation test:

The allergic reaction on guinea pigs of patch of the present invention and enema Rat-rectum medication irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to respectively to intend 20 times, 2.5 times of clinical people's consumption [0.04g (medicated powder)/kg], through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to respectively to intend 125,80 times of clinical people's consumption, in official hour, observe mucous membrane of rectum all without phenomenons such as hyperemia, edema, histopathologic examination and blank group be no significant difference relatively, have no and occur obvious irritative response, every group of its overall health of patients of Some Animals of retaining, body weight, breathing, circulation, central nervous system and extremity activity etc., all Non Apparent Abnormality reactions.

Pharmacological experiment

The curative effect of Chinese medicine preparation of the present invention (capsule) is proved by pharmacodynamics test and clinical prerun below:

One. on the have loose bowels impact of model of Oleum Ricini induced mice

Get 40 of ICR mices, male and female half and half, are divided into model control group, Bacillus Licheniformis Capsule group, the present invention's (capsule) high dose group, low dose group at random.Give relative medicine 0.2ml/10gB.W. by organizing gavage respectively, model group gives equal-volume normal saline, once a day, and continuous three days.After last administration 40 minutes, every animal gavage gives 0.2ml Oleum Ricini.Then under mice being put into, be placed with the cell isolation cage of filter paper, one of every lattice.Observation index: muck counting; The filter paper that spreads one 10cm × 10cm area under every cell is made muck counting.React with muck grain number the degree of having loose bowels, first 1～6 hour replacing filter paper per hour once, changes paper once in 7～24 hours, records the accumulation muck sum of each animal in 24 hours, with model control group comparison, and t inspection between organizing with SPSS software.The results are shown in Table one.

Show the anti-diarrhea effect (X ± SD) of having loose bowels due to a pair of Oleum Ricini

Note: with model control group comparison, * * P < 0.01, * * * P < 0.001

From table one, medicine of the present invention can significantly suppress Oleum Ricini induced mice and have loose bowels.

Two. to intestinal propulsion exercise test

Get 40 of ICR mices, male and female half and half, are divided into Normal group, imodium group, high dose group of the present invention, low dose group at random.Give respectively relative medicine 0.2ml/10gB.W. by organizing gavage respectively, Normal group gives equal-volume normal saline, once a day, and continuous four days.Each group mice starts fasting 24 hours for the 3rd day after administration.Test the 4th day, after administration 1 hour, gavage 5% Insta-Char 0.2ml/10gB.W..After 20 minutes, de-cervical vertebra is put to death animal, open abdominal cavity, separate mesentery, on clip to pylorus, down to the intestinal tube between ileocecus, be placed on flat pallet, gently small intestinal is pulled into straight line, measure Length of intestine as " small intestinal total length ", the distance from pylorus to prepared Chinese ink forward position is as " prepared Chinese ink is at enteral advance distance ".Calculate prepared Chinese ink ink propulsive rate, t inspection between organizing with SPSS software.The results are shown in Table two.

The impact (X ± SD) of table two on intestinal propulsion motion

Note: with Normal group comparison, * * P < 0.01, * * * P < 0.001.

From table two, the present invention and imodium all have obvious inhibitory action to intestinal propulsion function.

Three, In vitro Bactericidal Experiments

Adopt agar doubling dilution to measure the minimum inhibitory concentration (MIC) of the present invention to common pathogen.Tested bacterium is inoculated in MH broth bouillon, cultivates after 18 hours for 35 DEG C, adjust its turbidity and reach the turbidity of 0.5 Maxwell opacity tube standard, bacterial content is about 108CFU/ml.With 1: 10 (the about 107CFU/ml of bacteria containing amount) of physiological saline solution dilution.Get respectively the medicinal liquid 2ml having diluted for series concentration and add in the flat board that performs labelling, then get the MH agar culture medium 18ml that has been chilled to 50 DEG C of left and right after thawing be added to dull and stereotyped in (medicine: agar=1: 9), medicine and culture medium are fully mixed.Medicine ultimate density is respectively 200,100,50 ... 0.78,0.39mg/ml.The bacteria suspension having prepared is inoculated on pastille flat board with inoculating loop, and in 18 hours observed results of 35 DEG C of cultivations, the lowest concentration of drug that colony growth is suppressed is completely that this medicine is to detecting the MIC of bacterium.Single bacteria growing can be ignored.Medicine contrast and strain growth contrast are established in test simultaneously.The results are shown in Table three.

Table three extracorporeal bacteria inhibitor test result

Bacterial strain	Minimum inhibitory concentration (MIC) (mg/ml)
		Shigella flexneri	4.135
Paratyphoid bacillus A	11.8
		Bacillus paratyphosus B	27
Bacillus pyocyaneus	5.95
		Escherichia coli	51
Colitis bacillus	23
		Staphylococcus aureus	6.18

From table three, medicine of the present invention all has certain antibacterial action to shigella flexneri, paratyphoid bacillus A, Bacillus paratyphosus B, escherichia coli, bacillus pyocyaneus, staphylococcus aureus, colitis bacillus.

L data and method

1.1 data

Classification foundation: Western medicine diagnose standard is with reference to national inflammatory bowel academic conference in 2000 " ulcer knot colitis diagnostic criteria and the standard of curative effect evaluation "." the study of tcm new drug guide " that tcm diagnosis standard is promulgated with reference to National Drug Administration.

1.2 clinical data

This group case 25 examples, male 14 examples, female's 11 examples.25～58 years old age, the course of disease 2 months 1 years, above case all has chronic diarrhoea, stomachache, the mucosanguineous feces history of outbreak repeatedly.Be divided into through sigmoidoscopy lesion degree: I degree pathological changes 9 examples, taking mucosa congestion and edema as feature, 2～3 times/d of diarrhoea number of times; II degree pathological changes 10 examples, taking mucosal erosion oozing of blood as feature, 4～5 times/d of diarrhoea number of times; III degree pathological changes 6 examples, taking mucosa face ulcer as feature, >6 >/d of diarrhoea number of times.Have 11 cases once to do the inspection of x sheet barium enema, 12 example promptings have knot colitis, and 3 example reports are normal.All cases are all got rid of the patient of the person that has severe complication, pregnancy period and women breast-feeding their children and concurrent liver, kidney, hemopoietic system serious disease).

I.3 method

Prescriptions of Chinese medicine: Radix Pulsatillae 15g, Rhizoma Dioscoreae 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Scutellariae 10g, Radix Sophorae Flavescentis 10g, Semen Myristicae 10g, Rhizoma Atractylodis Macrocephalae 15g, Poria 10g, Radix Sanguisorbae 10g, Bulbus Allii Macrostemonis 10g, Pericarpium Arecae 10g, Rhizoma Coptidis 10g, Pericarpium Citri Reticulatae 10g, Alumen 15g, Cortex Fraxini 10g, Massa Medicata Fermentata (parched to brown) 10g, Fructus Schisandrae Chinensis 10g, Rhizoma Zingiberis Recens 15g, it is for subsequent use to about 250ml that Pericarpium Granati 15g adds decocting.

According to the state of an illness, get above-mentioned enema 60-80Hd retention enema at every turn, 2～3 times/d, 20min is at least adhered in each requirement, the coloclysis time, fluid temperature and human body temperature were adapted to suitable taking sooner or later as good.FI clothes before famotidine tablets 40mg sleeps, 1 time/d.If any stomachache, uncomfortable person can add Anisodamine sheet 20mg, and 1～2 time/d, 10d is 1 basic course for the treatment of.

1.4 efficacy determination

Recovery from illness: through transference cures such as treatment diarrhoea, stomachache, mucosanguineous feces, burning sensation of the anus, tenesmus, sigmoidoscopy intestinal mucosa is normal; Take a turn for the better: diarrhoea, mucosanguineous feces number of times reduce, burning sensation of the anus, tenesmus disappear, and stomachache obviously alleviates, sigmoidoscopy, and intestinal mucosa pathological changes has obvious change; Invalid: symptom and sigmoidoscopy are front unchanged with treatment.

2 results

1 of 2.1I degree pathological changes healing person's 7 examples course for the treatment of; Another 2 examples have been carried out the 2nd course for the treatment of and have been cured, and malaise symptoms all disappears.2 of II degree pathological changes healing person's 4 examples course for the treatment of; 2 examples take a turn for the better, and the diseases such as stomachache, burning sensation of the anus, tenesmus disappear, and diarrhoea number of times is reduced to 1～2 time; 1 example does not heal.III degree pathological changes is cured 2 examples 2 courses for the treatment of; 13 of examples are cured the course for the treatment of; 13 of examples take a turn for the better the course for the treatment of, and the diseases such as stomachache, burning sensation of the anus, tenesmus obviously alleviate, and diarrhoea number of times is reduced to 2-3 time; 1 example does not heal.

2.2 group cases are cured 18 examples altogether, 5 examples that take a turn for the better, and 2 examples do not heal.Cure rate 72%, improvement rate 20%, the rate 8% that do not heal, total effective rate 92%.

Specific embodiment 1: poplar, man, 42 years old.Patient suffered from abdominal pain since 2007, diarrhoea, separated 6-7 times/d of Mucous Stool, and sense burning sensation of the anus, tenesmus often bring out or increase the weight of after diet raw food, and once repeatedly treatment was not healed.Through sigmoidoscopy, see intestinal mucosa extensive edema, hyperemia, rectum and sigmoid colon intersection are dispersed in ulcer face, are diagnosed as chronic ulcerative knot colitis, are thought of as III degree pathological changes according to feature.Fang Yong: Radix Pulsatillae 10g, Rhizoma Dioscoreae 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Radix Scutellariae 10g, Radix Sophorae Flavescentis 10g, Semen Myristicae 10g, Rhizoma Atractylodis Macrocephalae 15g, Poria 10g, Radix Sanguisorbae 10g, Bulbus Allii Macrostemonis 15g, Pericarpium Arecae 10g, Rhizoma Coptidis 15g, Pericarpium Citri Reticulatae 10g, Alumen 15g, Cortex Fraxini 10g, Massa Medicata Fermentata (parched to brown) 15g, Fructus Schisandrae Chinensis 10g, Rhizoma Zingiberis Recens 15g, Pericarpium Granati 15g.Give after an action of the bowels retention enema, 3 times/d with above-mentioned enema 80ml.Through treating 2 courses for the treatment of continuously, times of defecation reduces, and stomachache alleviates, and drug withdrawal 3d renews front and treats 1 course for the treatment of, and stomachache disappears, and times of defecation is normal.Romanoscope check, intestinal mucosa is normal, pays a return visit and has no recurrence.

Specific embodiment 2: pay certain, female, 51 years old.Patient suffered from abdominal pain since 2006, diarrhoea, separated 5-7 times/d of Mucous Stool, and sense burning sensation of the anus, tenesmus often bring out or increase the weight of after diet raw food, and once repeatedly treatment was not healed.Through sigmoidoscopy, see intestinal mucosa extensive edema, hyperemia, rectum and sigmoid colon intersection are dispersed in ulcer face, are diagnosed as chronic ulcerative knot colitis, are thought of as II degree pathological changes according to feature.Fang Yong: Radix Pulsatillae 15g, Rhizoma Dioscoreae 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Radix Scutellariae 10g, Radix Sophorae Flavescentis 10g, Semen Myristicae 10g, Rhizoma Atractylodis Macrocephalae 15g, Poria 10g, Radix Sanguisorbae 10g, Bulbus Allii Macrostemonis 15g, Pericarpium Arecae 10g, Rhizoma Coptidis 15g, Pericarpium Citri Reticulatae 10g, Alumen 15g, Cortex Fraxini 10g, Massa Medicata Fermentata (parched to brown) 10g, Fructus Schisandrae Chinensis 15g, Rhizoma Zingiberis Recens 15g, Pericarpium Granati 10g.Give after an action of the bowels retention enema with above-mentioned enema 80ml, each 20 to 40 minutes, 3 times/d.Through treating 2 courses for the treatment of continuously, times of defecation reduces, and stomachache alleviates, and drug withdrawal 3d makes pill with the present invention again, and stomachache disappears, and times of defecation is normal.Romanoscope check, intestinal mucosa is normal, pays a return visit and has no recurrence.

Specific embodiment 3: the Qin, man, 38 years old.Patient is thin and weak from little health, and unknown cause diarrhoea, becomes thin.Suffered from abdominal pain, suffer from diarrhoea since 2007, separate 6-7 times/d of Mucous Stool, sense burning sensation of the anus, tenesmus often bring out or increase the weight of after diet raw food, and once repeatedly treatment was not healed.Through sigmoidoscopy, see intestinal mucosa extensive edema, hyperemia, rectum and sigmoid colon intersection are dispersed in ulcer face, are diagnosed as chronic ulcerative knot colitis, are thought of as III degree pathological changes according to feature.Fang Yong: Radix Pulsatillae 10g, Rhizoma Dioscoreae 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Radix Scutellariae 10g, Radix Sophorae Flavescentis 10g, Semen Myristicae 15g, Rhizoma Atractylodis Macrocephalae 15g, Poria 150g, Radix Sanguisorbae 10g, Bulbus Allii Macrostemonis 15g, Pericarpium Arecae 10g, Rhizoma Coptidis 15g, Pericarpium Citri Reticulatae 15g, Alumen 15g, Cortex Fraxini 10g, Massa Medicata Fermentata (parched to brown) 10g, Fructus Schisandrae Chinensis 15g, Rhizoma Zingiberis Recens 10g, Pericarpium Granati 15g; Give after an action of the bowels retention enema with above-mentioned enema 60ml, each 20 to 40 minutes, 3 times/d.Through treating 3 courses for the treatment of continuously, times of defecation reduces, and stomachache alleviates, and drug withdrawal 5d makes pill 30 days with taking the present invention again, and stomachache disappears, and times of defecation is normal.Romanoscope check, intestinal mucosa is normal, pays a return visit and has no recurrence.

Specific embodiment 4: Lin, female, 21 years old.Patient's unknown cause diarrhoea, becomes thin.Suffered from abdominal pain, suffer from diarrhoea since 2008, separate 2-3 times/d of Mucous Stool, sense burning sensation of the anus, tenesmus often bring out or increase the weight of after diet raw food, and once repeatedly treatment was not healed.Through sigmoidoscopy, see intestinal mucosa edema, hyperemia, rectum and sigmoid colon intersection are dispersed in ulcer face, are diagnosed as chronic ulcerative knot colitis, are thought of as I degree pathological changes taking mucosa congestion and edema as feature, 2～3 times/d of diarrhoea number of times according to feature; Fang Yong: Radix Pulsatillae 15g, Rhizoma Dioscoreae 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Radix Scutellariae 15g, Radix Sophorae Flavescentis 10g, Semen Myristicae 15g, Rhizoma Atractylodis Macrocephalae 15g, Poria 150g, Radix Sanguisorbae 10g, Bulbus Allii Macrostemonis 15g, Pericarpium Arecae 10g, Rhizoma Coptidis 10g, Pericarpium Citri Reticulatae 15g, Alumen 15g, Cortex Fraxini 10g, Massa Medicata Fermentata (parched to brown) 10g, Fructus Schisandrae Chinensis 15g, Rhizoma Zingiberis Recens 15g, Pericarpium Granati 10g, give after an action of the bowels retention enema with above-mentioned enema 50ml, each 20 to 40 minutes, 3 times/d.Through treating 3 courses for the treatment of continuously, stomachache disappears, and times of defecation is normal.Romanoscope check, intestinal mucosa is normal, pays a return visit and has no recurrence.

Claims (2)

1. treat the Chinese medicine preparation of chronic colitis for one kind, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: 10～20 parts of the Radix Pulsatillaes, 10～20 parts of Rhizoma Dioscoreaes, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Semen Myristicaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts, Poria, 10～20 parts of Radix Sanguisorbaes, 10～20 parts of Bulbus Allii Macrostemonis, 10～20 parts of Pericarpium Arecae, 10～20 parts of Rhizoma Coptidis, 10～20 parts of Pericarpium Citri Reticulataes, 10～20 parts of Alumens, 10～20 parts of Cortex Fraxinis, 10～20 parts of Massa Medicata Fermentata (parched to brown), 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts, Rhizoma Zingiberis Recens, 10～20 parts of Pericarpium Granatis.

2. treat according to claim 1 the Chinese medicine preparation of chronic colitis, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: 10～15 parts of the Radix Pulsatillaes, 10～15 parts of Rhizoma Dioscoreaes, 10～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Sophorae Flavescentiss, 10～15 parts of Semen Myristicaes, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts, Poria, 10～20 parts of Radix Sanguisorbaes, 10～20 parts of Bulbus Allii Macrostemonis, 10～20 parts of Pericarpium Arecae, 10～20 parts of Rhizoma Coptidis, 10～20 parts of Pericarpium Citri Reticulataes, 10～20 parts of Alumens, 10～20 parts of Cortex Fraxinis, 10～20 parts of Massa Medicata Fermentata (parched to brown), 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts, Rhizoma Zingiberis Recens, 10～20 parts of Pericarpium Granatis.