CN108553652A - A kind of x-ray barium enema examination enteron aisle contrast medium and preparation method thereof - Google Patents
A kind of x-ray barium enema examination enteron aisle contrast medium and preparation method thereof Download PDFInfo
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- CN108553652A CN108553652A CN201810545257.3A CN201810545257A CN108553652A CN 108553652 A CN108553652 A CN 108553652A CN 201810545257 A CN201810545257 A CN 201810545257A CN 108553652 A CN108553652 A CN 108553652A
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Classifications
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention belongs to field of traditional Chinese medicine technology, are related to a kind of x-ray barium enema examination enteron aisle contrast medium, are made of the raw material below according to parts by weight：200 250 grams of barium sulfate, 70 90 grams of Chinese medicine composition, appropriate amount of water, the Chinese medical extract is prepared by following raw material components：Radix Astragali, coix seed, the root of Dahurain angelica, Radix Sangusorbae, radix scutellariae, pueraria lobata, Herba Euphorbiae Humifusae is windproof, radix bupleuri；Above-mentioned Chinese medicine material is crushed to, is impregnated, decocted, filtered and to obtain liquid；The dregs of a decoction decoct, are ultrasonically treated, centrifuge upper liquid；By gained liquid and upper liquid mixing up to Chinese medicine composition.The present invention has enteron aisle full good; imaging is clear; lower digestive tract mucous membrane is protected simultaneously, is treated chronic colitis, drug can be made directly to reach diseased region; it is clean can also to play the role of local douche simultaneously; to reach antidiarrheal anti-inflammatory, relieving spasm and pain improves local blood circulation and metabolism; enhance intestinal immunity, promotes the purpose of ulcer healing.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of x-ray barium enema examination enteron aisle contrast medium and its
Preparation method, enteron aisle when being checked for lower digestive tract x-ray is full, belongs to the field of Chinese medicines.
Background technology
Contrast medium is also known as contrast agent, is injected for enhancing Imaging Study effect（Or it takes）To tissue or organ
Chemicals.The density of these products is higher or lower than surrounding tissue, and formation has the display figure obviously compared with surrounding tissue
Picture.Contrast medium can be divided into two major classes, and it is low close that atomic weight is high, heavy high density contrast medium and atomic weight are low, proportion is small
Spend contrast medium.Wherein, " medicinal barium sulfate " is most common contrast medium, at low cost, easy to use, contrasting effects are good etc.
Advantage, but clinically there is poor taste in it, gastrointestinal tract fills the problems such as undesirable, time is long, contraindication is more, take orally
Or be affected to image check after bowel lavage, can not row CT or ultrasonic examination again, until be completely exhausted out it is external after can just carry out, sternly
The check process for affecting patient again is easy to cause patient and loses best therapic opportunity.In addition, medicinal barium sulfate disappears under
There is also certain taboos for the application in change road, and such as acute colitis or diverticulitis, nearly polypectomy and colon, enterobrosis is not
It can use.Traditional Chinese medical theory thinks that enterogastric diseases are mostly to be condensed into coke, deficiency of spleen-QI, deficiency-cold in spleen and stomach in product, damp-heat accumulation
Caused qi depression to blood stasis is caused, therefore when being treated using Chinese prescription, and product, eliminating dampness and heat, qi-regulating peace are attacked with treatment for relieving indigestion and constipation
In, invigorating the spleen tonifying Qi, middle benefit gas promoting blood circulation be this, reach the purpose for the treatment of both manifestation and root cause of disease, the contrast medium containing Chinese medical extract its image definition,
Comparison is apparent, physicochemical property is stablized, while having in eliminating dampness and heat, qi-regulating peace, the therapeutic efficiency of invigorating the spleen tonifying Qi, middle benefit gas promoting blood circulation,
Protective effect can be provided to gastrointestinal tract, be suitable for clinical gastrointestinal tract routine and special examination ultrasonic contrast.
Invention content
The object of the present invention is to provide a kind of x-ray barium enema examination enteron aisle contrast medium and preparation method thereof, physics and chemistry
It can stablize, imaging is clear, and enteron aisle is full good, and reduces gastral stimulation, protects lower digestive tract mucous membrane, while also having only
Anti-inflammatory is rushed down, relieving spasm and pain improves local blood circulation and metabolism, enhances intestinal immunity, promotes the mesh of ulcer healing
's.
To achieve the above object, the invention is realized by the following technical scheme：
A kind of x-ray barium enema examination enteron aisle contrast medium, it is characterised in that：It is made of the raw material below according to parts by weight：Sulfuric acid
200-250 parts of barium, 70-90 parts of Chinese medicine composition, appropriate amount of water, the Chinese medical extract is prepared by following raw material components：
Radix Astragali, coix seed, the root of Dahurain angelica, Radix Sangusorbae, radix scutellariae, pueraria lobata, Herba Euphorbiae Humifusae is windproof, radix bupleuri；Wherein Chinese medical extract is pressed by following raw materials
It is made according to the Chinese medicine of following parts by weight：30 parts of Radix Astragali, 30 parts of coix seed, 15 parts of the root of Dahurain angelica, 15 parts of Radix Sangusorbae, 15 parts of radix scutellariae,
15 parts of pueraria lobata, 30 parts of Herba Euphorbiae Humifusae, windproof 12 parts, 12 parts of radix bupleuri.
The method for making x-ray barium enema examination enteron aisle contrast medium, includes the following steps：
（1）By Radix Astragali, coix seed, the root of Dahurain angelica, Radix Sangusorbae, radix scutellariae, pueraria lobata, Herba Euphorbiae Humifusae is windproof, and radix bupleuri is ground into using pulverizer
The water of 6-8 times of said medicine total amount is added in 80-120 mesh, impregnates 30-60 minutes, decocts 1-2 hours, filters to obtain liquid；
（2）The dregs of a decoction of step 1 are added to 30-40 DEG C of warm water, after impregnating 20-40 minutes, after decocting 30-40 minutes, cool to 60-
70 DEG C, middle processing 15-20 minutes, upper liquid is centrifuged using centrifuge in 65-70 DEG C of ultrasonic container；
（3）By step（1）Gained liquid and step（2）Gained upper liquid mixing obtains upper liquid mixing by spray drying
It is powdered to get Chinese medical extract；
（4）By in step 3 obtained Chinese medical extract and barium sulfate weighed according to constant weight number, after being sufficiently mixed
Add water, reconciles as 36-40% (w/v) suspension.
Further, the ultrasonic power that ultrasonic container uses in the step 2 is 800W.
The pharmacological effect of each bulk pharmaceutical chemicals is as follows in Chinese medicine composition of the present invention：
Radix Astragali, sweet, warm, returns spleen, stomach.Invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.Modern pharmacological studies have shown that yellow
Stilbene has apparent humidification to specificity, nospecific immunity, adjusts interior environment to kill HP, stomach lining inflammation is promoted to repair
It is multiple.In addition there is research to confirm that Endothelin (ET) system may play an important role in contrast induced nephropathy CMN occurs, effectively inhibit to make
The excessively high expression of ET systems when shadow has certain Renoprotective Effect, and Radix Astragali can reduce blood plasma and kidney part ET-1 water
It is flat, have the function of inhibiting ET system expressions.Liu Yi etc. experiments prove that, generation of the Radix Astragali to diabetes contrast medium renal damage
There are certain prevention effect, this prevention effect may be related with kidney local endothelial element systemic effect is inhibited.
Coix seed, it is sweet, it is light, it is slightly cold, enters spleen, stomach, lung, large intestine channel；With clearing damp and promoting diuresis, invigorating the spleen to arrest diarrhea, clearing away heat and eliminating pus it
Effect can be used for treating the diseases such as diarrhea, muscle arteries and veins contraction, joint stuffiness, oedema, tinea pedis, acute appendicitis.
Radix scutellariae, bitter is cold in nature, enters lung, courage, stomach, large intestine channel, has effects that middle benefit gas, lower gas, eliminating dampness, eliminating the phlegm can be used
Do not disappear in treatment chest and abdomen swelling and pain, gastric disorder causing nausea, vomiting, place food, phlegmatic cough, the illnesss such as cold-dampness rush down dysentery.
The root of Dahurain angelica, it is acrid in flavour and warm in nature.Enter lung, stomach.With wind-dispelling, the effect of eliminating dampness, analgesic, apocenosis, myogenic.It can be used for having a headache, tooth
Bitterly, nasosinusitis, intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, pruitus.
Radix Sangusorbae, picric acid are trembled with fear, nontoxic channel tropism liver；Lung；Kidney；Large intestine channel effect cooling blood and hemostasis, clearing heat and detoxicating, detumescence
Sore.Cure mainly haematemesis, hemoptysis, hematuria, have blood in stool, hemorrhoid blood, bloody flux, the diseases such as leukorrhea with reddish discharge, sore, carbuncle and painful swelling, eczema, pruritus vulvae.
Pueraria lobata, it is sweet in flavor, pungent, it is cool in nature.It attaches to the lung and stomach meridians.It brings down a fever with expelling pathogenic factors from muscles and skin, promoting eruption promotes the production of body fluid to quench thirst, the work(of Shengyang Zhixie
Effect.It generates heat for exterior syndrome, stiff nape and back, measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat is purged heat dysentery, splenasthenic diarrhea.
Herba Euphorbiae Humifusae, acrid flavour；It is mild-natured, channel tropism：Lung, liver, stomach, large intestine.Bladder warp.With clearing heat and detoxicating, removing dampness through diuresis and removing jaundice, promoting blood circulation
The effect of hemostasis.For dysentery, diarrhea, spitting of blood, hematuria, have blood in stool, uterine bleeding, boil carbuncle swells, the diseases such as jaundice with damp-heat pathogen.
Windproof acrid flavour, sweet, slightly warm in nature；Return lung, spleen, liver, bladder warp；Gas perfume (or spice), which rises, to be dissipated；With expelling pathogenic wind from the body surface, damp dispelling and pain relieving,
The effect of soothing the liver spasmolysis, desinsection is antipruritic；It cures mainly and catches cold, have a headache Xiang Qiang, and dizzy dusk is puckery, wind-cold-dampness arthralgia, skeletal pain, abdominal pain
Diarrhea, discharging fresh blood stool, broken apoplexy, measles is difficult thoroughly, rubella itch.
Radix bupleuri, it is bitter, it is slightly cold, Return liver, gallbladder channel.It is soothing the liver in inducing diaphoresis, rising Yang.Cure mainly cat fever, fevers and chills alternate, malaria,
Assist distending pain, irregular menstruation.
The beneficial effects of the present invention are：
The contrast medium of the present invention has no toxic side effect under the synergistic effect of various medicine raw materials, easy to use, and physicochemical property is stablized,
Comparison is apparent, image definition, while reasonably combined Chinese prescription, avoids damage of the conventional contrast agents to enteron aisle, is suitable for normal
Advise the clysis with barium contrast medium of lower digestive tract inspection.Contrast medium enteron aisle of the present invention is full good, under imaging is clear, and Traditional-Chinese-medicine-type is reduced
Alimentary canal stimulates, and protects lower digestive tract mucous membrane, treats chronic colitis, drug can be made directly to reach diseased region, while can also
It is clean to play the role of local douche, there is antidiarrheal anti-inflammatory, relieving spasm and pain to improve local blood circulation and metabolism, enhancing
Intestinal immunity promotes the purpose of ulcer healing.
Description of the drawings
Fig. 1 is using Normal Colon radioscopy image after contrast medium bowel lavage in the present invention；
The colon ascendens, transverse colon, colon descendens, sigmoid colon and rectum fill good after per anum injection enteron aisle contrast medium of the present invention
Good, teniae coli is clear, and enteric cavity is without narrow and expansion.
Fig. 2 is using carcinoma of sigmoid radioscopy image after contrast medium bowel lavage in the present invention；
Per anum injects the narrow filling defect area of the visible limitation of sigmoid colon latter end after 1 enteron aisle contrast medium of comparative example, and barium agent is logical
Difficulty is crossed, remaining each section of teniae coli is clear, and enteric cavity is without narrow and expansion.
Fig. 3 is the tediously long radioscopy image of contrast medium bowel lavage postcolon in the application present invention；
The colon ascendens, transverse colon, colon descendens, sigmoid colon and rectum fill good after per anum injection 2 enteron aisle contrast medium of comparative example
Good, teniae coli is clear, and enteric cavity shows slightly tediously long without narrow and expansion, colon lengths.
Fig. 4 is using Normal Colon radioscopy image after contrast medium bowel lavage in the present invention.
Per anum injects the colon ascendens after the outstanding mixed liquid contrast medium of conventional sulfuric acid barium water, transverse colon, colon descendens, sigmoid colon and straight
Intestines are full good, and teniae coli is clear, and enteric cavity is without narrow and expansion.
Specific implementation mode
The present invention is described further with experimental example with reference to embodiments, it should be understood that described herein excellent
Select embodiment only for the purpose of illustrating and explaining the present invention and is not intended to limit the present invention.
Embodiment 1
A kind of x-ray barium enema examination enteron aisle contrast medium, it is characterised in that：It is made of the raw material below according to parts by weight：Sulfuric acid
200 grams of barium, 70 grams of Chinese medicine composition, appropriate amount of water.Wherein Chinese medicine composition is made of following Chinese medicine material：30 grams of Radix Astragali, the heart of a lotus seed
30 grams of the seed of jog's tears, 15 grams of the root of Dahurain angelica, 15 grams of Radix Sangusorbae, 15 grams of radix scutellariae, 15 grams of pueraria lobata, 30 grams of Herba Euphorbiae Humifusae, windproof 12 grams, 12 grams of radix bupleuri.
The method for making x-ray barium enema examination enteron aisle contrast medium, includes the following steps：
（1）By Radix Astragali, coix seed, the root of Dahurain angelica, Radix Sangusorbae, radix scutellariae, pueraria lobata, Herba Euphorbiae Humifusae is windproof, and radix bupleuri is ground into 80 using pulverizer
The water of 6 times of said medicine total amount is added in mesh, impregnates 30 minutes, decocts 1 hour, filters to obtain liquid；
（2）The dregs of a decoction of step 1 are added to 30-40 DEG C of warm water, impregnates after twenty minutes, after decocting 30 minutes, cools to 60 DEG C,
Middle processing 15 minutes, upper liquid is centrifuged using centrifuge in 65-70 DEG C of ultrasonic container；
（3）By step（1）Gained liquid and step（2）Gained upper liquid mixing obtains upper liquid mixing by spray drying
It is powdered to get Chinese medical extract；
（4）By in step 3 obtained Chinese medical extract and barium sulfate weighed according to constant weight number, after being sufficiently mixed
Temper be 750ml for liquor capacity after, obtain 36% (w/v) suspension.
Embodiment 2
1. a kind of x-ray barium enema examination enteron aisle contrast medium, it is characterised in that：It is made of the raw material below according to parts by weight：Sulphur
225 grams of sour barium, 80 grams of Chinese medicine composition, appropriate amount of water.Wherein Chinese medicine composition is made of following Chinese medicine material：30 grams of Radix Astragali,
30 grams of coix seed, 15 grams of the root of Dahurain angelica, 15 grams of Radix Sangusorbae, 15 grams of radix scutellariae, 15 grams of pueraria lobata, 30 grams of Herba Euphorbiae Humifusae, windproof 12 grams, radix bupleuri 12
Gram.
The x-ray barium enema examination method of enteron aisle contrast medium is made, is included the following steps：
（1）By Radix Astragali, coix seed, the root of Dahurain angelica, Radix Sangusorbae, radix scutellariae, pueraria lobata, Herba Euphorbiae Humifusae is windproof, and radix bupleuri is ground into using pulverizer
The water of 7 times of said medicine total amount is added in 100 mesh, impregnates 45 minutes, decocts 1.5 hours, filters to obtain liquid；
（2）The dregs of a decoction of step 1 are added to 40 DEG C of warm water, after impregnating 30 minutes, after decocting 30 minutes, 70 DEG C are cooled to, at 65 DEG C
Middle processing 20 minutes, upper liquid is centrifuged using centrifuge in ultrasonic container；
（3）By step（1）Gained liquid and step（2）Gained upper liquid mixing obtains upper liquid mixing by spray drying
It is powdered to get Chinese medical extract；
（4）By in step 3 obtained Chinese medical extract and barium sulfate weighed according to constant weight number, after being sufficiently mixed
It tempers as 800ml to get to 38% (w/v) suspension.
Embodiment 3
1. a kind of x-ray barium enema examination enteron aisle contrast medium, it is characterised in that：It is made of the raw material below according to parts by weight：Sulphur
250 grams of sour barium, 90 grams of Chinese medicine composition, appropriate amount of water.Wherein Chinese medicine composition is made of following Chinese medicine material：30 grams of Radix Astragali,
30 grams of coix seed, 15 grams of the root of Dahurain angelica, 15 grams of Radix Sangusorbae, 15 grams of radix scutellariae, 15 grams of pueraria lobata, 30 grams of Herba Euphorbiae Humifusae, windproof 12 grams, radix bupleuri 12
Gram.
The x-ray barium enema examination method of enteron aisle contrast medium is made, is included the following steps：
（1）By Radix Astragali, coix seed, the root of Dahurain angelica, Radix Sangusorbae, radix scutellariae, pueraria lobata, Herba Euphorbiae Humifusae is windproof, and radix bupleuri is ground into using pulverizer
The water of 8 times of said medicine total amount is added in 120 mesh, impregnates 60 minutes, decocts 2 hours, filters to obtain liquid；
（2）The dregs of a decoction of step 1 are added to 40 DEG C of warm water, is impregnated after forty minutes, is decocted after forty minutes, 70 DEG C are cooled to, at 70 DEG C
Middle processing 20 minutes, upper liquid is centrifuged using centrifuge in ultrasonic container；
（3）By step（1）Gained liquid and step（2）Gained upper liquid mixing obtains upper liquid mixing by spray drying
It is powdered to get Chinese medical extract；
（4）By in step 3 obtained Chinese medical extract and barium sulfate weighed according to constant weight number, after being sufficiently mixed
It tempers as 850ml, obtains 40% (w/v) suspension.
Comparative example 1
With contrast medium of the present invention difference lies in：Chinese medicine composition system in the preparation method of x-ray barium enema examination enteron aisle contrast medium
Chinese medicine composition twice by decocting for Chinese herbal medicine will be obtained by filtrate hybrid filtering, other are with each using traditional decoction mode twice when standby
Embodiment.
Comparative example 2
With contrast medium of the present invention difference lies in：Chinese medicine composition is made of following Chinese medicine material：It is 15 grams of Radix Notoginseng, 12 grams of Rhizoma Chuanxiong, red
Spend 12 grams, 30 grams of rheum officinale, 20 grams of saltcake, 20 grams of cassia twig, 20 grams of Poria cocos, 9 grams of ginkgo leaf, 12 grams of cubeb litsen tree, 30 grams of Radix Astragali, Rhizoma Atractylodis Macrocephalae
12 grams, 12 grams of fresh Radix Rehmanniae, 9 grams of dandelion.
The observation on Clinical Application of the present invention is as follows：
One, general information
Patient 180, male 97, women 83.Patient is without apparent ascites, the occupy-place of huge piece of abdominal cavity and gastrointestinal symptom.
Two, method
Patient is randomly divided into four groups, each 45.Control group distinguishes Comparison study example 1, comparative example 2, conventional sulfuric acid barium aqueous suspension.
After per anum pours into contrast medium, lower digestive tract contrast examination is carried out.Simultaneously with before lower digestive tract radiography and after radiography to the 3d times
Interior observation lower digestive tract situation.
Three, evaluation criteria
By colon intestinal tube, full, structure shows the contrast effect of degree evaluation contrast medium；Pass through the evaluation pair of lower digestive tract symptom
Having non-stimulated and lower digestive tract symptom to enteron aisle than agent, whether there is or not improvement.
Wherein, intestinal tube fills, structure shows that degree differentiates evaluation, and control is measured by lower digestive tract contrastographic picture.
Lower digestive tract symptom is evaluated, and by clinic, whether there is or not the asymptomatic controls such as tenesmus, abdominal pain, diarrhea.
Four, result
1, enteron aisle fills display degree
The full display of enteron aisle is all right, and for contrast medium by smooth, teniae coli shows that clearly contrast medium is evenly distributed in enteron aisle,
Consistent in density.
2, lower digestive tract contrastographic picture after colon is full
As can be seen that contrast medium of the present invention images apparent than comparative example 1 and comparative example 2 compared with Fig. 2 and Fig. 3, enteron aisle fills Fig. 1
Be full of it is more preferable, Fig. 1 with Fig. 4 compared with as can be seen that two groups clearly, enteron aisle fills relatively good, and imaging effect difference is little for imaging.
The above results show；Contrast medium rear intestinal filling effect of the present invention is ideal, and contrast medium is evenly distributed in enteron aisle, compares
Density value is ideal, and imaging is clear, no artifact.Comparative example 1 and comparative example 2 are slightly poor compared to experimental group effect, illustrate preparation of the present invention
Method and pharmaceutical composition dosage relation are that each medicine material collaboration works, are not that simple replacement effect is attainable.
3, lower digestive tract reacts number of cases
The above results show：Occurred without other malaise symptoms using contrast medium of the present invention, the symptom of original colitis disease, such as abdomen
It rushes down, abdominal pain, mucus bloody stool and the symptoms such as pus and blood stool, tenesmus largely mitigate, or even disappear.
4, non-toxic experiment explanation
Cell toxicity test, contrast medium Solution Cell toxicity≤1 grade, no skin are carried out according to standard GB/T/T16886.5-2003
Skin sensitivity response and intradermal stimulate the reaction.
Above-mentioned clinical test results show：The contrast medium of the present invention occurs without other adverse reactions；Contrast medium is reduced under
Lower digestive tract mucous membrane is protected in gastral stimulation；Simultaneously also have antidiarrheal anti-inflammatory, relieving spasm and pain, improve local blood circulation and
Metabolism enhances intestinal immunity, promotes the purpose of ulcer healing.
Finally it should be noted that：The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
With technical scheme described in the above embodiments is modified or equivalent replacement of some of the technical features.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in the present invention's
Within protection domain.
Claims (3)
1. a kind of x-ray barium enema examination enteron aisle contrast medium, it is characterised in that：It is made of the raw material below according to parts by weight：Sulphur
Sour barium 200-250 parts, 70-90 parts of Chinese medicine composition, appropriate amount of water, the Chinese medical extract by following raw material components prepare and
At：Radix Astragali, coix seed, the root of Dahurain angelica, Radix Sangusorbae, radix scutellariae, pueraria lobata, Herba Euphorbiae Humifusae is windproof, radix bupleuri；Wherein, wherein Chinese medical extract is under
Raw material is stated to be made according to the Chinese medicine of following parts by weight：30 parts of Radix Astragali, 30 parts of coix seed, 15 parts of the root of Dahurain angelica, 15 parts of Radix Sangusorbae are yellow
15 parts of a kind of reed mentioned in ancient books, 15 parts of pueraria lobata, 30 parts of Herba Euphorbiae Humifusae, windproof 12 parts, 12 parts of radix bupleuri.
2. making the x-ray barium enema examination method of enteron aisle contrast medium as described in claim 1, include the following steps：
（1）By Radix Astragali, coix seed, the root of Dahurain angelica, Radix Sangusorbae, radix scutellariae, pueraria lobata, Herba Euphorbiae Humifusae is windproof, and radix bupleuri is adopted according to above-mentioned parts by weight
The water of 6-8 times of said medicine total amount is added with pulverizer powder, impregnates 30-60 minutes, decocts 1-2 hours, liquid is obtained after filtering；
（2）The dregs of a decoction of step 1 are added to 30-40 DEG C of warm water, are impregnated 20-40 minutes, after decocting 30-40 minutes, cool down 60-70
DEG C, middle processing 15-20 minutes, upper liquid is centrifuged using centrifuge in 65-70 DEG C of ultrasonic container；
（3）By step（1）Gained liquid and step（2）Gained upper liquid mixing obtains upper liquid mixing by spray drying
It is powdered to get Chinese medical extract；
（4）By in step 3 obtained Chinese medical extract and barium sulfate weigh, tempered after being sufficiently mixed as 36%-
40% (w/v) suspension.
3. according to the production method of the x-ray barium enema examination enteron aisle contrast medium described in claim 2, in the step 2
The ultrasonic power that ultrasonic container uses is 800W.
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Application publication date: 20180921 |