CN103920027A - Medicament for treating acute jaundice hepatitis B and preparation method thereof - Google Patents

Medicament for treating acute jaundice hepatitis B and preparation method thereof Download PDF

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CN103920027A
CN103920027A CN201410125102.6A CN201410125102A CN103920027A CN 103920027 A CN103920027 A CN 103920027A CN 201410125102 A CN201410125102 A CN 201410125102A CN 103920027 A CN103920027 A CN 103920027A
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王萍萍
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Abstract

The invention discloses a medicament for treating acute jaundice hepatitis B and a preparation method thereof. The medicament comprises the following raw medicinal materials: wrinkled giant hyssop, cortex magnoliae officinalis, poria, rhizoma alismatis, corn stigma, calabash, cortex acanthopanacis, cortex ailanthi, plantain seed, shepherdspurse herb, chingma abutilon seed, oriental wormwood, lysimachia chiristinae hance, hypericum japonicum, abrus cantoniensis hance, sedum sarmentosum, common leafflower herb with root, medicated leaven and fevervine. The medicament has the beneficial effects that the medicament has main functions of clearing heat and promoting diuresis, strengthening spleen and eliminating dampness by utilizing the traditional Chinese medical theory, and has the advantages of quick response, exact curative effect, high safety, no toxic or side effect and relapse prevention when being used for treating acute jaundice hepatitis B.

Description

Be used for the treatment of medicine of acute icteric hepatitis B and preparation method thereof
 
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of medicine that is used for the treatment of acute icteric hepatitis B and preparation method thereof.
 
Background technology
Acute icteric hepatitis B is a kind of of hepatitis B Clinical typing, has acute and chronic dividing in hepatitis B is clinical.No matter acute and chronic, all can show as icteric or non-icteric type.The jaundice depth of icteric depends mainly on the situation of bile capillary degree of congestion and hepatic necrosis and obstruction biliary tract path.The whole course of disease of acute icteric hepatitis B is generally divided into 3 stages, i.e. pre-icterus stage, stage of icterus and convalescent period.
Though jaundice is dark during cholestatic hepatitis, patient's ordinary circumstance is often better, only have when continuing jaundice, or jaundice is when sharply increase aggravation or cause the consequence of biliary cirrhosis.
Most hepatitis B patient jaundice deepen to parallel with hepatic necrosis degree, and jaundice is darker, and clinical symptoms is heavier, and the state of an illness can be to acute or subacute severe hepatitis development.But and do not mean that infectiousness is strong.The depth of jaundice is only relevant with the weight of the state of an illness as can be seen here, does not contact directly with infectiousness.
Whether the infectiousness of hepatitis B and hepatitis B virus mass formed by blood stasis and hepatitis B virus active copy relevant.Change relevant with the index of " and two half " clinically.It is generally acknowledged, no matter patient is icteric or non-icteric type, also no matter be acute or chronic, as long as surface antigen, e antigen and the positive person's infectiousness of core antibody three are just stronger.Infectiousness power also with in blood, exist the number of hepatitis B virus deoxyribonucleic and deoxyribonucleic polymerase relevant.
Adult's acute jaundice clinical manifestation: the whole course of disease of acute icteric hepatitis B is generally divided into 3 stages, the pre-icterus stage of being, stage of icterus and convalescent period, its clinical manifestation is as follows: the pre-icterus stage of (1), from patient, start to have symptom to there is jaundice during this period of time, be about week a few days to 2.During onset, patient often feels fear of cold, heating, 38 ℃ of left and right of body temperature, hot a few days of the sustainable height of small number of patients.More outstanding symptom is that general fatigue is unable, loss of appetite, feel sick, vomiting, especially detest greasy food, the stifled distension of epigastrium is vexed, yellowish urine is like strong tea water, the rarer or constipation of defecating.This stage because individual variation, patient show complicated variously should be specifically noted that easily by mistaken diagnosis, if any patient show as upper respiratory tract infection, similar flu.Some patient can accompany joint aches and be mistaken as rheumatism.Also there are a few peoples to have tormina and think acute abdomen by mistake.Also have the measles such as a few peoples can occur.This interim end, haves a medical check-up and can find percussion tenderness over hepatic region and tenderness, under patient's costal margins more than half, can touch liver, and serum alanine aminotransferase (ALT) obviously raises, and urine bilirubin is positive.Hepatitis b surface antigen positive, hepatitis B core antibody IgM (anti--HBcIgM) positive.In this phase patient's blood, defecation, vomitus, all contain a large amount of hepatitis viruss, thereby have very strong infectiousness.(2) stage of icterus patient consolidates strand (a white of the eye part), skin and mucosa xanthochromia, reaches peak in a few days by 2 weeks.Now send out febrile lysis, digestion symptom but further increases the weight of.Liver enlargement tenderness, patient's spleen of approximately 10%-35% also enlargement also can touch.Hemogram leukocyte is normal or slightly on the low side, and liver function test is obviously abnormal, and serum bilirubin is more than 17 micromoles per liter (seeing for 1.0 milligrams).This phase generally approximately continues 2-6 week.(3) jaundice fades and moves back convalescent period, and symptom progressively disappears, and liver, splenomegaly day by day bounce back, and liver function trend is recovered until normal, to schedule to last approximately 4 weeks.
Motherland's medical science thinks, acute icteric hepatitis B belongs to jaundice category.Jaundice is to wait exopathogen owing to experiencing epidemic disease caused by damp-heat pathogen poison, causes turbid damp retardance, the imbalance of taste hepato-biliary function, bile Bu Xunchang road, a kind of disease of liver-gallbladder that icteric sclera, yellowish body, yellowish urine be main clinical manifestation of take of overflowing and causing with blood.
The cause of disease of yellow cellulitis mainly contains diseases caused by exogenous pathogenic factor seasonal pathogen, injury due to diet, and weakness of the spleen and stomach and liver and bile stone, long-pending piece stasis blocking etc., its internal and external reasons often of falling ill combines.The seasonal pathogen such as diseases caused by exogenous pathogenic factor seasonal pathogen diseases caused by exogenous pathogenic factor turbid damp, damp and hot, epidemic disease is malicious are from mouth and people pents up in middle Jiao, and transporting and transforming function of the spleen and stomach is not normal, and damp and hot fumigating in taste involved liver and gall, so that the liver failing to maintain the normal flow of QI, bile Bu Xunchang road, overflows with blood, excessive skin, upper note eyes, dirty bladder, makes body order urine all yellow, forms jaundice.If epidemic disease poison, compared with severe one, can injure nutrient blood, the pericardium that caves in, sends out as acute jaundice; Injury due to diet irregular diet or be addicted to drink excessively, all can impairing the spleen and stomach, so that transportation capabilities dereliction of duty, endogenous damp formation; with taste rise and fall of yin and yang or from transconversion into heat or from cold transformation, fumigate or block in taste liver and gall, cause the liver failing to maintain the normal flow of QI; bile Bu Xunchang road, overflows with blood, contamination skin and turning to be yellow.As < < Medical Treasures of the Golden Chamber jaundice abnormal pulse, demonstrate,proving and control > > says: " indigestion, the stomach being averse to turbility, turbid QI flowing downwards, urinary obstruction ... health is yellow to the greatest extent, and name is said jaundice due to immoderate eating."; Weakness of the spleen and stomach element body weakness of the spleen and stomach, or overstrain, damage of the spleen loses fortune, deficiency of qi and blood, the liver failing to be nourished of a specified duration, catharsis dereliction of duty, and cause bile Bu Xunchang road, and with blood, overflowing, contamination skin, sends out as jaundice.If plain body spleen YANG deficiency, spleen sun is injured after being ill, wet by Nei Sheng from cold transformation, burnt in stagnation of cold-damp, bile is obstructed, and causes bile Bu Xunchang road, with blood, overflows, contamination skin, also can send out as yellow cellulitis.In addition, liver and bile stone, long-pending piece stasis blocking biliary tract, bile Bu Xunchang road, overflows with blood, also can cause yellow cellulitis.
From traditional Chinese medical science angle, the Characteristics of Syndromes of primary disease is icteric sclera, yellowish body, yellow urine, wherein take icteric sclera as principal character.Ill from the beginning of, icteric sclera, yellowish body not necessarily occur, and with fever with aversion to cold, inappetence, nausea and vomiting, abdominal swelling, limbs are tired, and heavily to wait flu-like symptoms be main, after three or five days, just engenders icteric sclera, occurs yellowish urine and yellowish body thereupon.Also have and first occur side of body rib severe pain, then jaundice person.The course of disease or length or short.Yellowing is shallow or dark, and its color is distinct or dark and gloomy, acute jaundice person, and its color is very as gold.The diseases such as acute jaundice patient also can occur high fever coma, epistaxis haematemesis.Often there is eating and drinking without temperance, contact with hepatitis patient, or take the medical histories such as medicine of infringement liver.
Modern medicine treatment acute icteric hepatitis B should be lain up, give light, be rich in the diet of nutrition and absorption easy to digest, note the absorption of protein and vitamin; Nausea and vomiting causes impact feed, shortage of heat person and should infuse every day and supplement as glucose etc.Actively carry out liver protection treatment, but because the curative effect of multiple hepatinica is also imprecise, therefore only need select 1~2 kind, as reduced glutathion, and should not use too much hepatinica, otherwise also can increase the weight of the physiological load of liver; The medicine such as diammonium glycyrrhizinate, motassium magnessium aspartate is the subicteric medicine that subtracts of commonly using at present.Most acute hepatitises do not need antiviral therapy.But for the course of disease, delay surpasses 8 weeks, and frequent recurrence person can consider to adopt antiviral therapy.Generally how not advocate to apply adrenocortical hormone, and avoid application to the prejudicial diet of liver and medicine.Therapeutic scheme is limited at present, and clinical effectiveness is not desirable especially.
 
Summary of the invention
Technical problem to be solved by this invention is, a kind of medicine for the treatment of acute icteric hepatitis B and preparation method thereof is provided, this medicine be take clearing away heat-damp and promoting diuresis, invigorating the spleen for eliminating dampness as main, and that treatment acute icteric b hepatitis has is rapid-action, determined curative effect, safe, the advantage that has no side effect and be difficult for recurring.
In order to solve the problems of the technologies described above, the invention provides a kind of medicine that is used for the treatment of acute icteric hepatitis B, wherein, comprise following raw medicinal material: Herba Pogostemonis, Cortex Magnoliae Officinalis, Poria, Rhizoma Alismatis, Stigma Maydis, calabash, CORTEX ACANTHOPANACIS, Cortex Ailanthi, Semen Plantaginis, Herba Capsellae, Semen Abutili, Herba Artemisiae Scopariae, Herba Lysimachiae, Herba Hyperici Japonici, Herba Abri, Herba Sedi, Herba Phyllanthi Urinariae, Massa Medicata Fermentata and fevervine.
In described medicine, the parts by weight of each raw medicinal material are preferably: Herba Pogostemonis 15-30 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Poria 15-26 weight portion, Rhizoma Alismatis 18-30 weight portion, Stigma Maydis 15-25 weight portion, calabash 18-26 weight portion, CORTEX ACANTHOPANACIS 15-27 weight portion, Cortex Ailanthi 18-30 weight portion, Semen Plantaginis 15-30 weight portion, Herba Capsellae 15-30 weight portion, Semen Abutili 15-30 weight portion, Herba Artemisiae Scopariae 15-30 weight portion, Herba Lysimachiae 15-25 weight portion, Herba Hyperici Japonici 15-25 weight portion, Herba Abri 18-30 weight portion, Herba Sedi 18-30 weight portion, Herba Phyllanthi Urinariae 15-25 weight portion, Massa Medicata Fermentata 15-30 weight portion and fevervine 15-30 weight portion.
In described medicine, the parts by weight of each raw medicinal material can also be preferably: Herba Pogostemonis 18-25 weight portion, Cortex Magnoliae Officinalis 17-23 weight portion, Poria 18-24 weight portion, Rhizoma Alismatis 21-27 weight portion, Stigma Maydis 18-23 weight portion, calabash 20-25 weight portion, CORTEX ACANTHOPANACIS 18-25 weight portion, Cortex Ailanthi 20-28 weight portion, Semen Plantaginis 18-27 weight portion, Herba Capsellae 15-27 weight portion, Semen Abutili 19-25 weight portion, Herba Artemisiae Scopariae 19-30 weight portion, Herba Lysimachiae 19-23 weight portion, Herba Hyperici Japonici 17-23 weight portion, Herba Abri 19-27 weight portion, Herba Sedi 19-26 weight portion, Herba Phyllanthi Urinariae 18-23 weight portion, Massa Medicata Fermentata 18-25 weight portion and fevervine 18-27 weight portion.
In described medicine, the parts by weight of each raw medicinal material can be preferably again: Herba Pogostemonis 21 weight portions, Cortex Magnoliae Officinalis 19 weight portions, Poria 22 weight portions, Rhizoma Alismatis 24 weight portions, Stigma Maydis 20 weight portions, calabash 23 weight portions, CORTEX ACANTHOPANACIS 21 weight portions, Cortex Ailanthi 24 weight portions, Semen Plantaginis 19 weight portions, Herba Capsellae 22 weight portions, Semen Abutili 22 weight portions, Herba Artemisiae Scopariae 24 weight portions, Herba Lysimachiae 20 weight portions, Herba Hyperici Japonici 20 weight portions, Herba Abri 23 weight portions, Herba Sedi 22 weight portions, Herba Phyllanthi Urinariae 20 weight portions, Massa Medicata Fermentata 21 weight portions and fevervine 21 weight portions.
Described medicine also comprises: Herba Pteridis Multifidae, Herba Selaginellae Moellendorfii, Radix Gossampini, Herba Leonuri He Herba Rorippae.
In described medicine, the parts by weight of each raw medicinal material are preferably: Herba Pogostemonis 15-30 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Poria 15-26 weight portion, Rhizoma Alismatis 18-30 weight portion, Stigma Maydis 15-25 weight portion, calabash 18-26 weight portion, CORTEX ACANTHOPANACIS 15-27 weight portion, Cortex Ailanthi 18-30 weight portion, Semen Plantaginis 15-30 weight portion, Herba Capsellae 15-30 weight portion, Semen Abutili 15-30 weight portion, Herba Artemisiae Scopariae 15-30 weight portion, Herba Lysimachiae 15-25 weight portion, Herba Hyperici Japonici 15-25 weight portion, Herba Abri 18-30 weight portion, Herba Sedi 18-30 weight portion, Herba Phyllanthi Urinariae 15-25 weight portion, Massa Medicata Fermentata 15-30 weight portion, fevervine 15-30 weight portion, Herba Pteridis Multifidae 18-25 weight portion, Herba Selaginellae Moellendorfii 18-26 weight portion, Radix Gossampini 10-20 weight portion, Herba Leonuri 10-20 weight portion is with Herba Rorippae 10-25 weight portion.
In described medicine, the parts by weight of each raw medicinal material can also be preferably: Herba Pogostemonis 23 weight portions, Cortex Magnoliae Officinalis 18 weight portions, Poria 19 weight portions, Rhizoma Alismatis 23 weight portions, Stigma Maydis 18 weight portions, calabash 21 weight portions, CORTEX ACANTHOPANACIS 20 weight portions, Cortex Ailanthi 24 weight portions, Semen Plantaginis 23 weight portions, Herba Capsellae 21 weight portions, Semen Abutili 22 weight portions, Herba Artemisiae Scopariae 18 weight portions, Herba Lysimachiae 18 weight portions, Herba Hyperici Japonici 18 weight portions, Herba Abri 23 weight portions, Herba Sedi 22 weight portions, Herba Phyllanthi Urinariae 20 weight portions, Massa Medicata Fermentata 21 weight portions, fevervine 21 weight portions, Herba Pteridis Multifidae 21 weight portions, Herba Selaginellae Moellendorfii 22 weight portions, Radix Gossampini 15 weight portions, Herba Leonuri 15 weight portions are with Herba Rorippae 17 weight portions.
In order better to realize foregoing invention object, the present invention also provides a kind of medicine that is used for the treatment of acute icteric hepatitis B, and the dosage form of described medicine is capsule, and described preparation method comprises the following steps:
A, get Herba Pogostemonis, Cortex Magnoliae Officinalis, Poria and Herba Artemisiae Scopariae, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, and medicinal residues are standby; The extraction of described volatile oil adopts steam distillation or supercritical fluid extraction;
B, the medicinal residues mixing of getting surplus stock medical material and described step a, add 60%-90% ethanol, soaks 0.5-1.5 hour, extracts twice, and each 1-2 hour, adds for the first time 5-10 and doubly measure, and adds for the second time 5-10 and doubly measures, and merge extractive liquid,, filters; 1.10-1.50 when concentrating filtrate to relative density and being 80 ℃, precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 ℃, obtains extractum; Described extraction adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method;
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill, grind 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
The dosage form of described medicine is decoction, and its preparation method comprises the following steps:
A, by Herba Pogostemonis, Cortex Magnoliae Officinalis, Poria and Herba Artemisiae Scopariae to put into 10 times of amount alcoholic degrees be 85% ethanol, heating and refluxing extraction 2 times, each 1~2 hour, extract active ingredient, 2 extracting solution are merged standing, obtain component 1;
B, surplus stock medical material is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 30 minutes~1 hour, 3 extracting solution are merged standing, obtain component 2;
C, said components 1 and component 2 merged, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting, obtain tablet.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: medicine of the present invention, utilize the traditional theory of Chinese medical science of China, take clearing away heat-damp and promoting diuresis, invigorating the spleen for eliminating dampness as main, and that treatment acute icteric b hepatitis has is rapid-action, determined curative effect, safe, the advantage that has no side effect and be difficult for recurring.
 
The specific embodiment
The invention provides a kind of medicine for the treatment of acute icteric hepatitis B, wherein, comprise following raw medicinal material: Herba Pogostemonis, Cortex Magnoliae Officinalis, Poria, Rhizoma Alismatis, Stigma Maydis, calabash, CORTEX ACANTHOPANACIS, Cortex Ailanthi, Semen Plantaginis, Herba Capsellae, Semen Abutili, Herba Artemisiae Scopariae, Herba Lysimachiae, Herba Hyperici Japonici, Herba Abri, Herba Sedi, Herba Phyllanthi Urinariae, Massa Medicata Fermentata and fevervine; Preferably, can also comprise following raw medicinal material: Herba Pteridis Multifidae, Herba Selaginellae Moellendorfii, Radix Gossampini, Herba Leonuri He Herba Rorippae.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Herba Pogostemonis: pungent, tepor.Return spleen, stomach, lung meridian.< < pearl sac > >: " benefit is defended gas, and stomach reinforcing gas, enters diet, controls again and tells contrary cholera." Li Shizhen (1518-1593 A.D.) says: " Herba Pogostemonis square-stem has in joint empty, and Ye Wei is like Folium Solani Melongenae.Clean Gu, Dong Yuan only use its leaf, need not branch stalk.Moderns branch obstruct with it, and therefore Yin Yeduo is pseudo-ear." removing dampness by means of aromatics, stomach function regulating preventing or arresting vomiting, dispelling summer-heat from superficies of the body.Gastral cavity abdomen painful abdominal mass Min of main retention of dampness in middle-JIAO, inappetence, vomiting, has loose bowels, the headache of the cold and heat of diseases caused by exogenous pathogenic factor heat-damp in summer, hygropyrexia from the beginning of heating body tired, feel sick in breast Min, nasal sinusitis, tinea manus and pedis.Agastache rugosa water decoct has inhibitory action to leptospira when concentration is 15mg/ml; When concentration increases to 31mg/ml, leptospira is had to killing action.< < Bencao Jingshu > >: " hyperactivity of fire caused by deficiency of YIN, the weak nausea of stomach and gastric heat are felt sick, and middle burnt fire is contained thermoae, epidemic febrile disease calentura, the positive bright stomach man domination of pathogen is done swollen, and method is also forbidden.”
Cortex Magnoliae Officinalis: hardship, pungent, warm in nature; Return spleen channel, stomach warp, large intestine channel.Function: circulation of qi promoting removing food stagnancy, dampness is removed full, lowering the adverse QI to relieve asthma.Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively cause the quickening of saliva, gastric secretion, gastrointestinal peristalsis, and have stomach invigorating digestion-aid effect.Experiment in vitro proves, Cortex Magnoliae Officinalis decoct all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus subtilis. and experiment shows, with other 61 kinds of Chinese medicines, compare, Cortex Magnoliae Officinalis is the strongest to the effect of Staphylococcus albus, bacillus subtilis, escherichia coli and Bacillus typhi. its bactericidal action that act as to Staphylococcus albus and bacillus subtilis.In vitro, Cortex Magnoliae Officinalis is strong to the inhibitory action of staphylococcus aureus compared with Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei. and decoct (1:1) is diluted at 1/640 o'clock, and its bacteriostasis is still better than chlortetracycline. and the antibacterial action of decoct is not because heating destroys.
Poria: sweet, light, flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness.< < medication heart method > >: " sweet with supporing yang, the panacea of dehumidifying also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, the inducing QI of promoting the production of body fluid." modern study shows that the interaction energy many-side that Poria has an enhancing immunity regulates immunologic function.Poria has significant inhibitory action to staphylococcus aureus, Bacillus proteus.Concoct: be soaked in water, clean, after profit, slightly steam, cut in time skin and piece or cut sheet, dry.Medication taboo: the deficiency of YIN and without damp and hot, deficiency and coldness spermatorrhea, the careful clothes of collapse of QI person.< < Collective Notes to Canon of Materia Medica > >: " Chinese small iris makes for it.Dislike and hold back in vain.Fear Rhizoma Paridis tetraphyllae, Radix Sanguisorbae, Realgar, Radix Gentianae Macrophyllae, Carapax Et Plastrum Testudinis." < < must join herbal > >: " collapse of QI, water dry up xerostomia all forbid ".
Rhizoma Alismatis: sweet in the mouth, light, cold in nature, enter kidney, urinary bladder channel, theory of Chinese medical science thinks that it is cold in nature, has promoting diuresis to eliminate damp pathogen, the lung that clears away heart-fire, rushes down the effect of kidney fire.Be mainly used in insufficiency of the spleen retention of water-damp, the wet hydrosarca of spreading unchecked of water; The tired resistance of heresy of diseases caused by retention of fluid phlegm-damp, causes dizzy that clear YANG failing to ascend voiced sound does not fall; The dysuria of damp invasion of lower energizer, red short puckery pain, and the card such as jaundice due to damp-heat.Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Rhizoma Alismatis and preparation modern times thereof are also used for the treatment of auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.But Rhizoma Alismatis has liver toxicity, nephrotoxicity, it is improper to take, and can allow liver, kidney occur swelling and other poisoning symptoms.
Stigma Maydis: sweet in the mouth is flat, < < Compendium of Materia Medica > >: " Limonitum, hands, the positive bright blood system heavy prescription of foot are also.Its property is puckery, therefore all diseases before and after the main part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.The first poem of Li Zhi is said, and the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels has the difficult meeting of patient, must use surplus grain Halloysitum Rubrum." the < < book on Chinese herbal medicine > > that looks for the truth: " and Limonitum merit is identical with Halloysitum Rubrum, and the matter of Limonitum overweights Halloysitum Rubrum, the temperature of Halloysitum Rubrum, and too surplus grain, must distinguish." there are the effects such as inducing diuresis to remove edema, blood pressure lowering, hemostasis, function of gallbladder promoting, can treat various diseases.Stigma Maydis can accelerate Blood Coagulation Process, improves number of platelets, can anti-hemolysis, so can be used as the hemorrhage diuretic of holding concurrently, be applied to bladder and lithangiuria, and can also be for acute hemolytic anemia.Because it has anti-allergic effects, so also can be used for the treatment of urticaria and asthma etc.The function of detoxification of Stigma Maydis can be used for treating mastitis etc.In addition, Stigma Maydis also has appetizing effect.
Calabash: sweet in the mouth, property is smoothly nontoxic, and it is climing, palpus, leaf, flower, son, shell all can be used as medicine, and cures various diseases.According to ancient medical book, record, flower of Herba Eichhorniae sweet in the mouth, property is flat, nontoxic, can do the medicine detoxifying, particularly effective to various fistula skin ulcers.Climing, must the property of medicine with spend identically, can control numb skin ulcer.Calabash flesh and son, bitter in the mouth, cold in nature, poisonous, can control odontopathy, gingiva or swollen or dew, odontoseisis.Can control appearance, edema in the extremities again, urinary obstruction, nasal obstruction, and all carbuncle malignant boil.Especially the highest with the medical value of calabash shell, its sweet in the mouth, property is flat, and nontoxic, for heat reliving and toxin-eliminating, lung moistening is convenient.
CORTEX ACANTHOPANACIS: warm in nature, acrid in the mouth, hardship; Return liver, kidney, heart channel.< < Traditional Chinese Medicine in Sichuan will > >: " analgesia, except rheumatism.Control anemofrigid-damp arthralgia, the contracture of foot knee joint, bones and muscles pain." wind-damp dispelling, bone and muscle strengthening.For anemofrigid-damp arthralgia, soreness of the waist and knees, shortness of breath and palpitation, edema of lower limbs.During slender acanthopanax bark spirit processed, need cautiously, because periploca sepium cardiotonic is very strong, consumption is too much easily poisoning.Be injected in animal, can make its increased blood pressure high, about 3-20 minute can be lethal; CORTEX ACANTHOPANACIS warm in nature and, injection after blood pressure without very change.Join Radix Angelicae Pubescentis, expelling wind and dampness, effect strengthens, and is especially suitable for insufficiency of kidney-YANG, anemofrigid-damp arthralgia, soreness of waist and knee joint.
Cortex Ailanthi: bitter, puckery, cold; Return large intestine, stomach, Liver Channel.< < property of medicine opinion > >: " control dysentery with red and white feces, intestinal is sliding, and haemorrhoids rushes down blood not to be noted." < < Bencao Shiyi > >: " main red white chronic dysentery, infantile malnutrition worm, goes scabies, main hematochezia." heat clearing and damp drying, astringent therapy leukorrhagia stopping, antidiarrheal, hemostasis.For leucorrhea with red and white discharge, damp-heat dysentery, chronic diarrhea chronic dysentery, has blood in stool, metrorrhagia.100% decoct has inhibitory action to shigella flexneri, Song's Shigella flexneri and escherichia coli in vitro.Ailanthinone has cytotoxic activity to human nasal pharyngeal cancer (KB) cell, and its ED50 is that 10-2-10-3ug/ml is when 0.12-4.00mg/kg dosage, to the certain activity of Lymphocytic leukemia P388 demonstration.Deficiency and coldness of spleen and stomach person be cautious use of.
Semen Plantaginis: sweet, light; Cold nature.Return lung meridian, Liver Channel, kidney channel, urinary bladder channel.There is clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Improving eyesight; The function of eliminating the phlegm.Cure mainly: main dysuria; Stranguria with turbid discharge leukorrhagia; Edema distension; Heat-damp in summer dysentery; Conjunctival congestion is hidden from view; Expectorant heat syndrome cough is breathed heavily.Modern pharmacology experiment shows: in vitro, Herba Plantaginis water logging agent to Trichophyton concentricunm, permitted the dermatophytess such as blue achorion, Du's big belly microspore tinea bacterium difficult to understand, rust microspore's tinea bacterium, ulotrichy microspore's tinea bacterium, star-shaped nocardia and had inhibitory action in various degree.Also there is report to point out, to various pathogens, as staphylococcus aureus, bacterium sonnei, escherichia coli, bacillus pyocyaneus and Bacillus typhi also have inhibitory action in various degree.Psyllic alcohol extract (15mg/ml) has killing action to leptospira.
Herba Capsellae: be slightly cold, sweet, light.Energy cooling blood for hemostasis, promoting urination to remove dampness, liver heat removing and eyesight improving.The modern Practical Chinese medicinal > of < < >: " hemostasis, controls pneumorrhagia, and metrorrhagia, miscarries hemorrhage, menorrhagia, headache, ophthalmalgia or retinal hemorrhage." Herba Capsellae has the effect of similar Ergota.Its extractum is tried out in animal leave one's post uterus or intestinal tube, is all remarkable contraction.Herba Capsellae extract (containing oxalic acid) intravenous injection or intramuscular injection (each 2-3ml, every 2-4 hour 1 time, every day the most multiplex 15ml) in various hemorrhages, have obvious anastalsis.The alcohol extract of Herba Capsellae, to dog, cat, rabbit, rat intravenous injection, can produce the property a crossed blood pressure drops, and this acts on not by 80 μ g/kg atropine institute antagonisms.
Semen Abutili: sweet, cold; Enter intestine and small intestine, urinary bladder channel.Row neatly intestinal, lactogenesis, clearing away heat and discharging pus.Control constipation and anuresis, gonorrhea, edema, women's galactozemia, breast swell and pain.Join Semen Benincasae, dampness removing pain relieving, sliding sharp evacuation of pus effect strengthens; Join sand Semen Abutili core, circulation of qi promoting stimulating milk secretion; Join Poria, invigorating spleen for diuresis; Join Semen Vaccariae, lactogenesis effect strengthens; Join Fructus Cannabis, moisturize, laxation, relieving constipation; Join Caulis Akebiae, for puerperal because of hot galactostasis, the constipation of body fluid loss, the puckery pain of pyretic stranguria, flaming up of heart-fire, aphtha of the mouth and tongue, vexed dark coloured urine.The fatty oil of seed and protein.Flower is containing anthocyan.Fresh Semen Abutili is containing monosaccharide 6.8~7.4%, sucrose 4.1~4.6 %, maltose 4.5~4.8%, starch 1.2%.Seed is containing 15%~20%, and wherein linoleic acid is main; Leaf is containing globulariacitrin, and the mucous matter of root, wherein has pentose, pentosan, methylpentosan, alduronic acid and trace methyl pentose.
Herba Artemisiae Scopariae: bitter, pungent, be slightly cold.Return spleen, stomach, liver, gallbladder meridian.Function clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis.Pharmaceutical research has function of gallbladder promoting, and liver function protecting is antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating.The effect of this product jaundice eliminating subcutaneous ulcer is excellent, therefore except for jaundice due to damp-heat, for the YIN jaundice disease because occurred by cold-damp or innate deficiency of YANG in the body, also can apply.But the product use as same in medicines such as Radix Aconiti Lateralis Preparata, Rhizoma Zingiberiss that must coordinate warming middle-JIAO to dispel cold, the effect of jaundice eliminating subcutaneous ulcer to play except YIN-cold.Herba Artemisiae Scopariae has significant hepatoprotective effect, and to first, hepatitis B, icterohepatitis, has significant curative effect.There is function of gallbladder promoting, promote bile secretion, the effect that in increase bile, cholic acid and bilirubin are discharged.Can increase heart coronary flow, improve microcirculation, and have blood pressure lowering, blood fat reducing, anticoagulation, diuresis is antipyretic relievings asthma, and drives away ascarid and suppresses the effect of multiple pathogenic dermatophytes and antibacterial.
Herba Lysimachiae: sweet in the mouth, micro-hardship, cool in nature; Return liver, gallbladder, kidney, urinary bladder channel.Function relieving stranguria by diuresis, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Cure mainly liver and gall and urinary system calculus, pyretic stranguria, oedema due to nephritis, jaundice due to damp-heat, sore carbuncle, venom, traumatic injury.Herba Lysimachiae has good dampness removing jaundice eliminating and the treating stranguria effect of calculus, treating the liver cholelithiasis and jaundice.In addition, Herba Lysimachiae is used for edema, tympanites, merit for oral administration, external application all has inducing diuresis to remove edema, and for cough due to lung-heat, infantile hyperpyrexia, is to get its antipyretic and antidote functions.Modern study, these product mainly contain phenolic constituent and sterol, flavonoid, aminoacid, tannin, volatile oil, choline, potassium salt etc., also have calculus, and antibacterial, antiinflammatory action, all has inhibitory action to humoral immunization, cellular immunization.
Herba Hyperici Japonici: bitter in the mouth, flat; Return liver, gallbladder meridian.The standby > > that wants of the < < SHENGCAO property of medicine: " control wine disease, subside a swelling swollen, apply large malignant boil, reason chancre is swollen." the < < south of the Five Ridges record > > that gathers medicinal herbs: " remove the yellow fire-toxin of nitre, apply shrimp pincers skin ulcer, reason traumatic injury, snakebite." dampness removing jaundice eliminating, heat-clearing and toxic substances removing, promoting blood circulation and detumescence.Control infectious hepatitis, dysentery, infantile convulsion, infantile malnutrition, throat moth, acute appendicitis, furuncle and phyma, venom.This product hardship is cool, enters liver and gall warp, can clear dampness-heat in the liver and gallbladder have function of gallbladder promoting jaundice, alone heavy dose of decoction or with the compatibility such as Herba Lysimachiae, Herba Artemisiae Scopariae, Rhizoma Polygoni Cuspidati.Acute icterohepatitis, chronic hepatitis are all had to therapeutical effect.This product promoting blood circulation and detumescence, for traumatic injury pain caused by ecchymoma, alone or join the decoctions such as Rhizoma Drynariae, Olibanum, Myrrha; Also can by fresh goods, mash external application simultaneously.Bacillus tuberculosis bovis, streptococcus pneumoniae, staphylococcus aureus, hog cholera bacillus and dysentery bacterium are had to antibacterial and bactericidal action in various degree in vitro.
Herba Abri: sweet, bitter, cool, nontoxic; Enter the heart, lung, liver, stomach, kidney channel.< < south of the Five Ridges herbal > >: " hot and suffocating clearly, soothing liver-QI, and spleen, continuous injured." clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.Main icterohepatitis, stomachache, rheumatic ostalgia, traumatic injury stasis of blood pain, mastalgia.For normal isolated rabbit ileum, Os Gallus domesticus grass roots decoct can significantly strengthen its shrinkage amplitude, and anesthetized rabbit gavage or intramuscular injection decoct also can make intestinal tube tension force in place improve, and wriggle and slightly strengthen.Os Gallus domesticus grass roots decoct 5g/kg gavages and can significantly strengthen Tolerance of Swimming.The thick Saponin of Herba Abri has remarkable protection effect to hepatic injury due to carbon tetrachloride (CCl4).Herba Abri is the medical herbs spreading among the people, and herbal medicine in ancient times is without record, mainly containing active chemicals such as yearning between lovers alkali, choline.Be applied to more at large at present treat hepatitis B and fall enzyme.
Herba Sedi: cool in nature, sweet in the mouth, cool; Return liver, gallbladder, small intestine meridian.Eliminating damp-heat, removing toxic substances.For jaundice due to damp-heat, dysuria, carbuncle skin infection, acute hepatitis, chronic hepatitis.There is the effect of the glutamate pyruvate transaminase of reduction.Activeness for acute hepatitis, chronic persistent hepatitis, chronic hepatitis.For burn due to hot liquid or fire, available fresh grass is cleaned and to be smash juice and be coated with outward; For carbuncle from the beginning of, except decoct soup for oral administration, with fresh grass is clean, mash external application simultaneously, also can eliminating carbuncle detumescent.Herba Sedi was the conventional medical herbs for the treatment of carbuncle sore among the people and venom originally, but off guard because of general shop of Chinese medicines, therefore different clinically in the past, applied less.These product of discovered in recent years can be with controlling infectious hepatitis, and reduction is turned to ammonia Enzyme good short term effect.
Herba Phyllanthi Urinariae: mildly bitter flavor is sweet, cool in nature, nontoxic.Powder for clearing heat and detoxicating gas for oral administration goes to amass; External sterilizing detumescent.Enter spleen lung meridian.Dysentery, summer-heat dysentery, Sunstroke heating, conjunctival congestion and swelling pain, infantile malnutrition, nyctalopia; External treatment venom, a Serpentis skin ulcer, skin flies Serpentis ovum, children's's summer boil.The protective effect of Cacumen Securinegae Suffruticosae sheet to D-Gal induced mice acute liver damage and carbon tetrachloride induced mice acute liver damage studied respectively in zoopery.All to chemicals, hepatic injury has significant protective effect to the high low dose group of result Cacumen Securinegae Suffruticosae.Animal experiment has been studied respectively Cacumen Securinegae Suffruticosae sheet to the formation impact of E-bow structure and the weightening finish of animal immune organ thymus.Two result of the tests show that Cacumen Securinegae Suffruticosae has obvious potentiation to the immunologic function of animal.Improved the antiviral ability of human body.
Massa Medicata Fermentata: nature and flavor are bitter, temperature.1. the < < property of medicine is examined > >: " micro-bitter fragrant sweet." the 2. < < detailed outline > > that picks up any lost article from the road: " and sweet light, delicate fragrance." enter spleen, stomach, large intestine channel.After flour, wheat bran and multi-medicament are mixed, the herbal leaven forming through fermentation.Can strengthening the spleen to promote digestion, regulating QI to expel dampness, induces sweat.The food feeling of stuffiness in chest that cures the wound, stomachache is vomited and diarrhoea, dysentery, headache due to common cold, children's hinder hungry lose full.In Massa Medicata Fermentata, there is yeast.Its composition has volatile oil, glycoside, fatty oil and vitamin B etc.< < Bencao Jingshu > > says: " ancients use bent, the song brewing alcoholic beverages, and the sweet temperature of its abnormal smells from the patient, the special food stagnation removing of property, the stagnant gas of row taste, loose internal organs are air-cooled.Massa Medicata Fermentata is that descendant specially makes, and with hyoscine, doubles in distillers yeast ".
Fevervine: property is flat, sweet in the mouth, micro-hardship.The standby > > that wants of the < < SHENGCAO property of medicine: " its head is controlled new internal injury, and pot is carnivorous, and tonify deficiency kidney tonifying, except fire is enriched blood; Wash skin ulcer pain relieving, the loose poison of the heat that disappears.Its leaf is beaten rice with confectionery, dysentery relieving." < < Zhiwu Mingshi Tukao > >: " be wash, removing toxic substances, removes wind, heat clearing away, cold expelling.Apply innominate toxic swelling, and mend muscles and bones." expelling wind and activating blood circulation, analgesic antidotal, dyspepsia and intestinal stasis relieving, dehumidifying detumescence.Dispelling the wind and dampness pathogens pain, diarrhoea dysentery, dirty abdomen pain, deficiency of vital energy edema, dizzy lack of appetite, hepatosplenomegaly, scrofula, acute appendicitis, innominate toxic swelling, traumatic injury.Fevervine total alkaloids lumbar injection can suppress mice voluntary activity, extends pentobarbital sodium length of one's sleep, has certain sedation.Fevervine total alkaloids can suppress myenteron and shrink, and the myenteron contracture due to energy antagonism acetylcholine.Fevervine decoct has inhibitory action to external staphylococcus aureus and Fu Shigella flexneri, and extractum also has bacteriostasis to staphylococcus aureus and streptococcus pneumoniae.
Herba Pteridis Multifidae: light, micro-hardship, cool.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances dysentery relieving, cooling blood for hemostasis.For dysentery, gastroenteritis, hepatitis, urinary system infection, cat fever, laryngopharynx swelling and pain, leucorrhea, metrorrhagia, pesticide intoxication; Traumatic hemorrhage is controlled in external, burn and scald.
Herba Selaginellae Moellendorfii: pungent, micro-sweet, flat.Function cures mainly: clearing away heat-damp and promoting diuresis, hemostasis.For acute icterohepatitis, anasarca, hemoptysis of pulmonary tuberculosis, spits blood, bleeding hemorrhoids; Traumatic hemorrhage is controlled in external, burn and scald.
Radix Gossampini: mildly bitter flavor; Cool in nature.Return spleen; Stomach warp.Function cures mainly: expelling wind and removing dampness; Heat-clearing and toxic substances removing; Removing obstruction for relieving pain.Main air pain of dampness syndrome; Stomachache; Bloody dysentery; Puerperal edema; Scrofula; Osteopatia sprain.
Herba Leonuri: bitter, pungent, be slightly cold.Return liver, pericardium channel.Function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Herba Rorippae: sweet, light, cool.Function cures mainly: heat-clearing and toxic substances removing, antitussive, diuresis.For cold, fever, laryngopharynx swelling and pain, cough due to lung-heat, chronic tracheitis, acute rheumatic arthritis, hepatitis, dysuria; Dermatitis rhus is controlled in external, venom, furuncle carbuncle.
 
In described medicine, the parts by weight of each raw medicinal material are preferably: Herba Pogostemonis 15-30 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Poria 15-26 weight portion, Rhizoma Alismatis 18-30 weight portion, Stigma Maydis 15-25 weight portion, calabash 18-26 weight portion, CORTEX ACANTHOPANACIS 15-27 weight portion, Cortex Ailanthi 18-30 weight portion, Semen Plantaginis 15-30 weight portion, Herba Capsellae 15-30 weight portion, Semen Abutili 15-30 weight portion, Herba Artemisiae Scopariae 15-30 weight portion, Herba Lysimachiae 15-25 weight portion, Herba Hyperici Japonici 15-25 weight portion, Herba Abri 18-30 weight portion, Herba Sedi 18-30 weight portion, Herba Phyllanthi Urinariae 15-25 weight portion, Massa Medicata Fermentata 15-30 weight portion and fevervine 15-30 weight portion.
In described medicine, the parts by weight of each raw medicinal material can also be preferably: Herba Pogostemonis 18-25 weight portion, Cortex Magnoliae Officinalis 17-23 weight portion, Poria 18-24 weight portion, Rhizoma Alismatis 21-27 weight portion, Stigma Maydis 18-23 weight portion, calabash 20-25 weight portion, CORTEX ACANTHOPANACIS 18-25 weight portion, Cortex Ailanthi 20-28 weight portion, Semen Plantaginis 18-27 weight portion, Herba Capsellae 15-27 weight portion, Semen Abutili 19-25 weight portion, Herba Artemisiae Scopariae 19-30 weight portion, Herba Lysimachiae 19-23 weight portion, Herba Hyperici Japonici 17-23 weight portion, Herba Abri 19-27 weight portion, Herba Sedi 19-26 weight portion, Herba Phyllanthi Urinariae 18-23 weight portion, Massa Medicata Fermentata 18-25 weight portion and fevervine 18-27 weight portion.
In described medicine, the parts by weight of each raw medicinal material can be preferably again: Herba Pogostemonis 21 weight portions, Cortex Magnoliae Officinalis 19 weight portions, Poria 22 weight portions, Rhizoma Alismatis 24 weight portions, Stigma Maydis 20 weight portions, calabash 23 weight portions, CORTEX ACANTHOPANACIS 21 weight portions, Cortex Ailanthi 24 weight portions, Semen Plantaginis 19 weight portions, Herba Capsellae 22 weight portions, Semen Abutili 22 weight portions, Herba Artemisiae Scopariae 24 weight portions, Herba Lysimachiae 20 weight portions, Herba Hyperici Japonici 20 weight portions, Herba Abri 23 weight portions, Herba Sedi 22 weight portions, Herba Phyllanthi Urinariae 20 weight portions, Massa Medicata Fermentata 21 weight portions and fevervine 21 weight portions.
Described medicine also comprises: Herba Pteridis Multifidae, Herba Selaginellae Moellendorfii, Radix Gossampini, Herba Leonuri He Herba Rorippae.
In described medicine, the parts by weight of each raw medicinal material are preferably: Herba Pogostemonis 15-30 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Poria 15-26 weight portion, Rhizoma Alismatis 18-30 weight portion, Stigma Maydis 15-25 weight portion, calabash 18-26 weight portion, CORTEX ACANTHOPANACIS 15-27 weight portion, Cortex Ailanthi 18-30 weight portion, Semen Plantaginis 15-30 weight portion, Herba Capsellae 15-30 weight portion, Semen Abutili 15-30 weight portion, Herba Artemisiae Scopariae 15-30 weight portion, Herba Lysimachiae 15-25 weight portion, Herba Hyperici Japonici 15-25 weight portion, Herba Abri 18-30 weight portion, Herba Sedi 18-30 weight portion, Herba Phyllanthi Urinariae 15-25 weight portion, Massa Medicata Fermentata 15-30 weight portion, fevervine 15-30 weight portion, Herba Pteridis Multifidae 18-25 weight portion, Herba Selaginellae Moellendorfii 18-26 weight portion, Radix Gossampini 10-20 weight portion, Herba Leonuri 10-20 weight portion is with Herba Rorippae 10-25 weight portion.
In described medicine, the parts by weight of each raw medicinal material can also be preferably: Herba Pogostemonis 23 weight portions, Cortex Magnoliae Officinalis 18 weight portions, Poria 19 weight portions, Rhizoma Alismatis 23 weight portions, Stigma Maydis 18 weight portions, calabash 21 weight portions, CORTEX ACANTHOPANACIS 20 weight portions, Cortex Ailanthi 24 weight portions, Semen Plantaginis 23 weight portions, Herba Capsellae 21 weight portions, Semen Abutili 22 weight portions, Herba Artemisiae Scopariae 18 weight portions, Herba Lysimachiae 18 weight portions, Herba Hyperici Japonici 18 weight portions, Herba Abri 23 weight portions, Herba Sedi 22 weight portions, Herba Phyllanthi Urinariae 20 weight portions, Massa Medicata Fermentata 21 weight portions, fevervine 21 weight portions, Herba Pteridis Multifidae 21 weight portions, Herba Selaginellae Moellendorfii 22 weight portions, Radix Gossampini 15 weight portions, Herba Leonuri 15 weight portions are with Herba Rorippae 17 weight portions.
When the dosage form of medicine is capsule, described preparation method comprises the following steps:
A, get Herba Pogostemonis, Cortex Magnoliae Officinalis, Poria and Herba Artemisiae Scopariae, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, and medicinal residues are standby; The extraction of described volatile oil adopts steam distillation or supercritical fluid extraction;
B, the medicinal residues mixing of getting surplus stock medical material and described step a, add 60%-90% ethanol, soaks 0.5-1.5 hour, extracts twice, and each 1-2 hour, adds for the first time 5-10 and doubly measure, and adds for the second time 5-10 and doubly measures, and merge extractive liquid,, filters; 1.10-1.50 when concentrating filtrate to relative density and being 80 ℃, precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 ℃, obtains extractum; Described extraction adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method;
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill, grind 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
When the dosage form of medicine is decoction, its preparation method comprises the following steps:
A, by Herba Pogostemonis, Cortex Magnoliae Officinalis, Poria and Herba Artemisiae Scopariae to put into 10 times of amount alcoholic degrees be 85% ethanol, heating and refluxing extraction 2 times, each 1~2 hour, extract active ingredient, 2 extracting solution are merged standing, obtain component 1;
B, surplus stock medical material is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 30 minutes~1 hour, 3 extracting solution are merged standing, obtain component 2;
C, said components 1 and component 2 merged, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting, obtain tablet.
 
Embodiment 1 capsule 1
The embodiment of the present invention provides a kind of medicine that is used for the treatment of acute icteric hepatitis B, in medicine, the parts by weight of each raw medicinal material are: Herba Pogostemonis 21 weight portions, Cortex Magnoliae Officinalis 19 weight portions, Poria 22 weight portions, Rhizoma Alismatis 24 weight portions, Stigma Maydis 20 weight portions, calabash 23 weight portions, CORTEX ACANTHOPANACIS 21 weight portions, Cortex Ailanthi 24 weight portions, Semen Plantaginis 19 weight portions, Herba Capsellae 22 weight portions, Semen Abutili 22 weight portions, Herba Artemisiae Scopariae 24 weight portions, Herba Lysimachiae 20 weight portions, Herba Hyperici Japonici 20 weight portions, Herba Abri 23 weight portions, Herba Sedi 22 weight portions, Herba Phyllanthi Urinariae 20 weight portions, Massa Medicata Fermentata 21 weight portions and fevervine 21 weight portions.
Said medicine obtains by following preparation method:
A, get Herba Pogostemonis, Cortex Magnoliae Officinalis, Poria and Herba Artemisiae Scopariae, add the water soaking 2 hours of 8 times of amounts, extract the volatile oil of 4 hours, collect volatile oil, medicinal liquid filters, and medicinal residues are standby; The extraction of described volatile oil adopts steam distillation;
B, the medicinal residues mixing of getting surplus stock medical material and described step a, add 80% ethanol, soaks 1 hour, extracts twice, and each 2 hours, add for the first time 8 times of amounts, add for the second time 8 times of amounts, merge extractive liquid,, filters; When concentrating filtrate to relative density and being 80 ℃ 1.20, precipitate with ethanol twice, adjusts concentration of alcohol to 80%, gets supernatant concentration to relative density while being 80 ℃ 1.20, obtains extractum; Described extraction adopts macroporous resin method;
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for 3% of extractum and volatile oil gross mass, mix, with colloid mill, grind 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
 
Embodiment 2 capsules 2
The embodiment of the present invention provides a kind of medicine that is used for the treatment of acute icteric hepatitis B, in medicine, the parts by weight of each raw medicinal material are: Herba Pogostemonis 30 weight portions, Cortex Magnoliae Officinalis 15 weight portions, Poria 26 weight portions, Rhizoma Alismatis 30 weight portions, Stigma Maydis 25 weight portions, calabash 18 weight portions, CORTEX ACANTHOPANACIS 27 weight portions, Cortex Ailanthi 18 weight portions, Semen Plantaginis 30 weight portions, Herba Capsellae 15 weight portions, Semen Abutili 30 weight portions, Herba Artemisiae Scopariae 15 weight portions, Herba Lysimachiae 15 weight portions, Herba Hyperici Japonici 15 weight portions, Herba Abri 30 weight portions, Herba Sedi 18 weight portions, Herba Phyllanthi Urinariae 15 weight portions, Massa Medicata Fermentata 30 weight portions, fevervine 15 weight portions, Herba Pteridis Multifidae 25 weight portions, Herba Selaginellae Moellendorfii 18 weight portions, Radix Gossampini 10 weight portions, Herba Leonuri 20 weight portions are with Herba Rorippae 10 weight portions.
Said medicine obtains by following preparation method:
A, get Herba Pogostemonis, Cortex Magnoliae Officinalis, Poria and Herba Artemisiae Scopariae, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, and medicinal residues are standby; The extraction of described volatile oil adopts supercritical fluid extraction;
B, the medicinal residues mixing of getting surplus stock medical material and described step a, add 85% ethanol, soaks 1.5 hours, extracts twice, and each 2 hours, add for the first time 8 times of amounts, add for the second time 6 times of amounts, merge extractive liquid,, filters; When concentrating filtrate to relative density and being 80 ℃ 1.30, precipitate with ethanol twice, adjusts concentration of alcohol to 85%, gets supernatant concentration to relative density while being 80 ℃ 1.20, obtains extractum; Described extraction adopts membrane separation technique;
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for 4% of extractum and volatile oil gross mass, mix, with colloid mill, grind 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
 
Embodiment 3 tablets
The embodiment of the present invention provides a kind of medicine that is used for the treatment of acute icteric hepatitis B, in medicine, the parts by weight of each raw medicinal material are: Herba Pogostemonis 23 weight portions, Cortex Magnoliae Officinalis 18 weight portions, Poria 19 weight portions, Rhizoma Alismatis 23 weight portions, Stigma Maydis 18 weight portions, calabash 21 weight portions, CORTEX ACANTHOPANACIS 20 weight portions, Cortex Ailanthi 24 weight portions, Semen Plantaginis 23 weight portions, Herba Capsellae 21 weight portions, Semen Abutili 22 weight portions, Herba Artemisiae Scopariae 18 weight portions, Herba Lysimachiae 18 weight portions, Herba Hyperici Japonici 18 weight portions, Herba Abri 23 weight portions, Herba Sedi 22 weight portions, Herba Phyllanthi Urinariae 20 weight portions, Massa Medicata Fermentata 21 weight portions, fevervine 21 weight portions, Herba Pteridis Multifidae 21 weight portions, Herba Selaginellae Moellendorfii 22 weight portions, Radix Gossampini 15 weight portions, Herba Leonuri 15 weight portions are with Herba Rorippae 17 weight portions.
A, by Herba Pogostemonis, Cortex Magnoliae Officinalis, Poria and Herba Artemisiae Scopariae to put into 10 times of amount alcoholic degrees be 85% ethanol, heating and refluxing extraction 2 times, each 2 hours, extract active ingredient, 2 extracting solution are merged standing, obtain component 1;
B, surplus stock medical material is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes, 3 extracting solution are merged standing, obtain component 2;
C, said components 1 and component 2 merged, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting, obtain tablet.
 
Toxicity test
Acute toxicity test: 60 of application NIH mices, SPF level, male and female half and half, body weight 17~24g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, matched group and administration group, test front fasting 12 hours; The capsule of embodiments of the invention 1 preparation is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet LD50>28.7 of the present invention crude drug/kg, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.6g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 21g) oral administration gavage Chinese medicine of the present invention is quantity 745 times.Therefore Chinese drug anesthesia medicine acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: by the capsule of the embodiment of the present invention 2 to mice by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Long term toxicity test: by the tablet of the embodiment of the present invention 3 to mice by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
 
Clinical trial
Case selection: the patient who fetches the 240 routine acute icteric b hepatitis that come from the patient of the court, course of disease 13-47 days, age 27-65 year, mean age is 41 years old, and the < < viral hepatitis that all cases is all drafted according to 2000 the 6th time academic meeting of national infectious disease parasite is prevented and treated " acute jaundice type viral hepatitis " diagnostic criteria in scheme > > and made a definite diagnosis.240 routine patients are divided into four groups at random, are respectively embodiment group 1, embodiment group 2, embodiment group 3 and matched group, every group of 60 people, and every group of patient's physical data difference not statistically significant, has comparability.
Therapeutic Method:
Embodiment group 1: take the capsule 1 of the embodiment of the present invention 1 preparation, every day 3 times, each 31 week is a course for the treatment of;
Embodiment group 2: take the capsule 2 of the embodiment of the present invention 2 preparations, every day 3 times, each 31 week is a course for the treatment of;
Embodiment group 3: take the tablet of the embodiment of the present invention 3 preparations, every day 3 times, each 31 week is a course for the treatment of;
Matched group: giving diammonium glycyrrhizinate 150mg and add 5% glucose injection 250mL intravenous drip, every day 1 time, 1 week is a course for the treatment of.
The standard of curative effect evaluation: draft with reference to the < < of State Administration of Traditional Chinese Medicine disease of tcm Standardization of diagnosis and curative effect > >, cure: skin, yellow sclera disappear, other transference cures, ALT, AST, TBIL recover normal; Take a turn for the better: skin, yellow sclera alleviate, and other symptoms are clearly better, and ALT, AST, TBIL obviously decline; Invalid: skin, yellow sclera is unchanged or deepen, other symptoms are without improvement, and ALT, AST, TBIL is unchanged or rise.
Therapeutic outcome:
Referring to table 1 and table 2, as can be seen from Table 1, adopt Drug therapy acute icteric hepatitis B of the present invention, with respect to matched group, on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy acute icteric hepatitis B of the present invention, with respect to conventional medicament, treating significantly shortening on the course for the treatment of.
After each group of table 1 is treated respectively 4 courses for the treatment of, Clinical efficacy comparison is routine
Group Number of cases Cure Take a turn for the better Invalid Effective percentage
Embodiment group 1 60 28 27 5 91.7%
Embodiment group 2 60 31 27 2 96.7%
Embodiment group 3 60 32 25 3 95.0%
Matched group 60 11 28 21 65.0%
Table 2 liang group is cured and improvement number and time comparative example (%) after treating respectively 4 courses for the treatment of
Group Number of cases The 1st course for the treatment of The 2nd course for the treatment of The 3rd course for the treatment of The 4th course for the treatment of
Embodiment group 1 55 9(16.4%) 20(36.4%) 14(25.5%) 12(21.8%)
Embodiment group 2 58 11(19.0%) 21(36.2%) 17(29.3%) 9(15.5%)
Embodiment group 3 57 10(17.5%) 21(36.8%) 16(28.1%) 10(17.5%)
Matched group 39 1(2.6%) 7(17.9%) 15(38.5%) 16(41.0%)
Known according to the clinical statistics in above table, that medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; The patient who each group is cured simultaneously and take a turn for the better follows up a case by regular visits to 1 year half, result statistics: 55 examples of curing and taking a turn for the better in embodiment group 1, and 28 routine patients of healing, without recurrence, are recurred 2 examples in 27 routine patients of improvement, and relapse rate is 3.6%; 58 examples of curing in embodiment group 2 and taking a turn for the better are all without recurrence; 57 examples of curing in embodiment group 3 and taking a turn for the better, 32 routine patients of healing are without recurrence, 1 case relapsed in 25 routine patients, relapse rate is 1.75%; 39 examples of curing and taking a turn for the better in matched group, 1 case relapsed in 11 routine patients of healing, recurs 8 examples in 28 routine patients of improvement, and relapse rate is 25.6%.
Model case: grandson, man, 47 years old, weak, poor appetite two weeks, about xanthochromia ten days, when to our hospital, poor appetite increases the weight of, and with nausea and vomiting, urine color is deepened as Umber, epigastrium pain, appetite reduces gradually, checks liver function: ALT 560U/L, AST 158.4U/L, TBIL365.8 μ mol/L.Be diagnosed as acute icteric hepatitis B.Use the capsule 2 of the embodiment of the present invention 2 preparations to treat, every day three times, each three 1 week is a course for the treatment of, uses take a turn for the better a course for the treatment of, and cure the course for the treatment of of continuing to take medicine, and follows up a case by regular visits to not recurrence in 1 year half.
 
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (9)

1. the medicine that is used for the treatment of acute icteric hepatitis B, it is characterized in that, described medicine comprises following raw medicinal material: Herba Pogostemonis, Cortex Magnoliae Officinalis, Poria, Rhizoma Alismatis, Stigma Maydis, calabash, CORTEX ACANTHOPANACIS, Cortex Ailanthi, Semen Plantaginis, Herba Capsellae, Semen Abutili, Herba Artemisiae Scopariae, Herba Lysimachiae, Herba Hyperici Japonici, Herba Abri, Herba Sedi, Herba Phyllanthi Urinariae, Massa Medicata Fermentata and fevervine.
2. the medicine that is used for the treatment of acute icteric hepatitis B according to claim 1, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Herba Pogostemonis 15-30 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Poria 15-26 weight portion, Rhizoma Alismatis 18-30 weight portion, Stigma Maydis 15-25 weight portion, calabash 18-26 weight portion, CORTEX ACANTHOPANACIS 15-27 weight portion, Cortex Ailanthi 18-30 weight portion, Semen Plantaginis 15-30 weight portion, Herba Capsellae 15-30 weight portion, Semen Abutili 15-30 weight portion, Herba Artemisiae Scopariae 15-30 weight portion, Herba Lysimachiae 15-25 weight portion, Herba Hyperici Japonici 15-25 weight portion, Herba Abri 18-30 weight portion, Herba Sedi 18-30 weight portion, Herba Phyllanthi Urinariae 15-25 weight portion, Massa Medicata Fermentata 15-30 weight portion and fevervine 15-30 weight portion.
3. the medicine that is used for the treatment of acute icteric hepatitis B according to claim 1 and 2, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Herba Pogostemonis 18-25 weight portion, Cortex Magnoliae Officinalis 17-23 weight portion, Poria 18-24 weight portion, Rhizoma Alismatis 21-27 weight portion, Stigma Maydis 18-23 weight portion, calabash 20-25 weight portion, CORTEX ACANTHOPANACIS 18-25 weight portion, Cortex Ailanthi 20-28 weight portion, Semen Plantaginis 18-27 weight portion, Herba Capsellae 15-27 weight portion, Semen Abutili 19-25 weight portion, Herba Artemisiae Scopariae 19-30 weight portion, Herba Lysimachiae 19-23 weight portion, Herba Hyperici Japonici 17-23 weight portion, Herba Abri 19-27 weight portion, Herba Sedi 19-26 weight portion, Herba Phyllanthi Urinariae 18-23 weight portion, Massa Medicata Fermentata 18-25 weight portion and fevervine 18-27 weight portion.
4. according to the medicine that is used for the treatment of acute icteric hepatitis B described in claim 1-3 any one, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Herba Pogostemonis 21 weight portions, Cortex Magnoliae Officinalis 19 weight portions, Poria 22 weight portions, Rhizoma Alismatis 24 weight portions, Stigma Maydis 20 weight portions, calabash 23 weight portions, CORTEX ACANTHOPANACIS 21 weight portions, Cortex Ailanthi 24 weight portions, Semen Plantaginis 19 weight portions, Herba Capsellae 22 weight portions, Semen Abutili 22 weight portions, Herba Artemisiae Scopariae 24 weight portions, Herba Lysimachiae 20 weight portions, Herba Hyperici Japonici 20 weight portions, Herba Abri 23 weight portions, Herba Sedi 22 weight portions, Herba Phyllanthi Urinariae 20 weight portions, Massa Medicata Fermentata 21 weight portions and fevervine 21 weight portions.
5. according to the medicine that is used for the treatment of acute icteric hepatitis B described in claim 1-4 any one, it is characterized in that, described medicine also comprises: Herba Pteridis Multifidae, Herba Selaginellae Moellendorfii, Radix Gossampini, Herba Leonuri He Herba Rorippae.
6. according to the medicine that is used for the treatment of acute icteric hepatitis B described in claim 1-5 any one, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Herba Pogostemonis 15-30 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Poria 15-26 weight portion, Rhizoma Alismatis 18-30 weight portion, Stigma Maydis 15-25 weight portion, calabash 18-26 weight portion, CORTEX ACANTHOPANACIS 15-27 weight portion, Cortex Ailanthi 18-30 weight portion, Semen Plantaginis 15-30 weight portion, Herba Capsellae 15-30 weight portion, Semen Abutili 15-30 weight portion, Herba Artemisiae Scopariae 15-30 weight portion, Herba Lysimachiae 15-25 weight portion, Herba Hyperici Japonici 15-25 weight portion, Herba Abri 18-30 weight portion, Herba Sedi 18-30 weight portion, Herba Phyllanthi Urinariae 15-25 weight portion, Massa Medicata Fermentata 15-30 weight portion, fevervine 15-30 weight portion, Herba Pteridis Multifidae 18-25 weight portion, Herba Selaginellae Moellendorfii 18-26 weight portion, Radix Gossampini 10-20 weight portion, Herba Leonuri 10-20 weight portion is with Herba Rorippae 10-25 weight portion.
7. according to the medicine that is used for the treatment of acute icteric hepatitis B described in claim 1-6 any one, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Herba Pogostemonis 23 weight portions, Cortex Magnoliae Officinalis 18 weight portions, Poria 19 weight portions, Rhizoma Alismatis 23 weight portions, Stigma Maydis 18 weight portions, calabash 21 weight portions, CORTEX ACANTHOPANACIS 20 weight portions, Cortex Ailanthi 24 weight portions, Semen Plantaginis 23 weight portions, Herba Capsellae 21 weight portions, Semen Abutili 22 weight portions, Herba Artemisiae Scopariae 18 weight portions, Herba Lysimachiae 18 weight portions, Herba Hyperici Japonici 18 weight portions, Herba Abri 23 weight portions, Herba Sedi 22 weight portions, Herba Phyllanthi Urinariae 20 weight portions, Massa Medicata Fermentata 21 weight portions, fevervine 21 weight portions, Herba Pteridis Multifidae 21 weight portions, Herba Selaginellae Moellendorfii 22 weight portions, Radix Gossampini 15 weight portions, Herba Leonuri 15 weight portions are with Herba Rorippae 17 weight portions.
8. the medicine that is used for the treatment of acute icteric hepatitis B as described in claim 1-7 any one, is characterized in that, the dosage form of described medicine is capsule, and described preparation method comprises the following steps:
A, get Herba Pogostemonis, Cortex Magnoliae Officinalis, Poria and Herba Artemisiae Scopariae, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, and medicinal residues are standby; The extraction of described volatile oil adopts steam distillation or supercritical fluid extraction;
B, the medicinal residues mixing of getting surplus stock medical material and described step a, add 60%-90% ethanol, soaks 0.5-1.5 hour, extracts twice, and each 1-2 hour, adds for the first time 5-10 and doubly measure, and adds for the second time 5-10 and doubly measures, and merge extractive liquid,, filters; 1.10-1.50 when concentrating filtrate to relative density and being 80 ℃, precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 ℃, obtains extractum; Described extraction adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method;
C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill, grind 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
9. the medicine that is used for the treatment of acute icteric hepatitis B as described in claim 1-7 any one, is characterized in that, the dosage form of described medicine is decoction, and its preparation method comprises the following steps:
A, by Herba Pogostemonis, Cortex Magnoliae Officinalis, Poria and Herba Artemisiae Scopariae to put into 10 times of amount alcoholic degrees be 85% ethanol, heating and refluxing extraction 2 times, each 1~2 hour, extract active ingredient, 2 extracting solution are merged standing, obtain component 1;
B, surplus stock medical material is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 30 minutes~1 hour, 3 extracting solution are merged standing, obtain component 2;
C, said components 1 and component 2 merged, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting, obtain tablet.
CN201410125102.6A 2014-03-31 2014-03-31 Medicament for treating acute jaundice hepatitis B and preparation method thereof Pending CN103920027A (en)

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CN104922310A (en) * 2015-05-21 2015-09-23 广东轻工职业技术学院 Traditional Chinese medicine composition with bacteriostasis function and application of traditional Chinese medicine composition to daily necessities
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CN104922310A (en) * 2015-05-21 2015-09-23 广东轻工职业技术学院 Traditional Chinese medicine composition with bacteriostasis function and application of traditional Chinese medicine composition to daily necessities
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Application publication date: 20140716