CN104474104A

CN104474104A - Traditional Chinese medicine composition for preventing and treating infectious rhinitis of chicken and preparation method thereof

Info

Publication number: CN104474104A
Application number: CN201410689886.5A
Authority: CN
Inventors: 刘应鹏; 卜昌超; 李建正
Original assignee: Zhengzhou Houyi Pharmaceutical Co Ltd
Current assignee: Zhengzhou Houyi Pharmaceutical Co Ltd
Priority date: 2014-11-26
Filing date: 2014-11-26
Publication date: 2015-04-01
Anticipated expiration: 2034-11-26
Also published as: CN104474104B

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating infectious rhinitis of chicken. The composition is prepared from the following raw materials in parts by weight: 9-18 parts of radix lsatidis, 12-21 parts of chrysanthemum indicum, 9-24 parts of saposhnicovia divaricata, 12-18 parts of scutellaria baicalensis, 6-18 parts of peppermint, 6-12 parts of ephedra, 6-15 parts of fructus xanthii, 6-15 parts of flos magnoliae, 6-15 parts of radix angelicae, 6-15 parts of ligusticum wallichii, 6-9 parts of angelica sinensis, 6-9 parts of safflower carthamus, 6-15 parts of notopterygium root, 12-24 parts of herba houttuyniae, 9-21 parts of agastache rugosa and 6-12 parts of licorice root. The traditional Chinese medicine composition has the effects of dispelling wind and heat, reducing phlegm, inducing diuresis, relieving stuffy nose and inducing resuscitation, and has the advantages of quick pharmacological action, good effect and no medicinal residue when used for preventing infectious rhinitis and chronic respiratory diseases of chicken; and the preparation method is simple, and is easy to popularize and apply.

Description

A kind of Chinese medicine composition preventing and treating infectious coryza of chicken and preparation method thereof

Technical field

The present invention relates to a kind of herbal medicine, particularly a kind of Chinese medicine composition preventing and treating infectious coryza of chicken and preparation method thereof.

Technical background

Infectious coryza of chicken be the one of the chicken caused by haemophilus paragallinarum with hole under eye conjunctiva, socket of the eye and nasal mucosa inflammation, face swelling, laying hen finishing period are infected, and mortality raises, laying period, to infect that then laying rate declines 10 ~ 40% be the acute respiratory disease of feature.

There is close relationship in the outbreak of infectious coryza of chicken and the external world particularly seasonal factors. and exopathogenic factor mostly is air-cooled steam, takes advantage of a weak point in opponent's defence and attacks, and lung loses logical tune, and body fluid stops gathering, and plug is filled in nose key and falls ill.Endogenous cause of ill then composes weakness, eating and drinking without temperance for examining, state food delicious food or extra large raw meat stimulating food of taking food, dysfunction of the spleen in transportation, and long-pending wet intrinsic heat, heat lies prostrate causes a disease in nose on lung.The traditional Chinese medical science is thought, lung governing qi, have one's ideas straightened out and nose, outer conjunction fur, the lung being the upper source of fluids, tears are the liquid of lung, the motion main manifestations of lung qi falls with respectful for a surname sends out, any physiological function of lung is all come by these two kinds of motor functions of lung, and the physiological property of lung is respectful clearly, and the property respectful clearly of lung is again the essential condition ensureing that a surname of lung qi falls motion and normally carries out.If because of exopathogen invasion and attack, or insufficiency of lung-QI, make impairment of purifying function of the lung, then motion falls in a surname that can have influence on lung, and then causes the physiological function of lung not normal.Simultaneously spleen renal dysfunction also can affect the normal physiological function of nose, and nose is taken advantage of relevant with lung spleen renal dysfunction, but main duty in lung.Its cause of disease mostly is heresy invasion and attack (wind and cold, wind heat or hold wet person under the arm) of unusual pathogen, and pathogenesis mostly is insufficiency of lung-QI, and it is loose to play reason, failure of defensive QI to protect the body against pathogen, exopathogen is taken advantage of a weak point, visitor to hinder caused by the lung in nose or lung originally not empty, because experiencing the heresy of unusual pathogen, damage lung qi, impairment of purifying function of the lung and causing.Theory of Chinese medical science is thought, characteristic of wind being apt to move in frequent change, matches to the feature of taking advantage of paroxysmal, repetitious Episodes and ailment said due to cold or exposure pathogenic.The ailment said due to cold or exposure that when source of ailment said due to cold or exposure has be four at two: one, climate change produces; Two is due to deficiency of liver-blood, deficiency of the yin of the liver, and liver is lost soft, and liver-yang is partially high and the endogenous wind that causes.In addition, also according to the clinical manifestation of disease, some doctor thinks that the pathogenesis of primary disease and addiction blood, latent heat, blood deficiency, liver and gall are got along well, hot and suffocating etc. has substantial connection.The present invention is with dispelling wind and heat pathogens, and reduce phlegm dampness removing, and stuffy nose relieving is had one's ideas straightened out for the rule for the treatment of.The medicine of dispelling wind pathogens, the loose then exterior syndrome solution of exopathogen; The medicine of clear key, to get rid of nasal secretion; The medicine dredging nasal obstruction of causing resuscitation with aromatic drugs.

Over the past two years, infectious coryza of chicken was popular especially serious, caused the tremendous economic of aviculture to be lost.The medicine of IC is a lot, and all has certain curative effect, but can remain at body or directly affect the fertility performance of chicken after drug use.

Summary of the invention

The object of this invention is to provide a kind of drug effect fast, effective, Chinese medicine composition of the control infectious coryza of chicken of drug residue free and preparation method thereof.

Prevent and treat a Chinese medicine composition for infectious coryza of chicken, be prepared from by the raw material of following weight portion: Radix Isatidis 9 ~ 18 parts, Flos Chrysanthemi Indici 12 ~ 21 parts, Radix Saposhnikoviae 9 ~ 24 parts, Radix Scutellariae 12 ~ 18 parts, Herba Menthae 6 ~ 18 parts, 6 ~ 12 parts, Herba Ephedrae, Fructus Xanthii 6 ~ 15 parts, Flos Magnoliae 6 ~ 15 parts, the Radix Angelicae Dahuricae 6 ~ 15 parts, Rhizoma Chuanxiong 6 ~ 15 parts, Radix Angelicae Sinensis 6 ~ 9 parts, 6 ~ 9 parts, Flos Carthami, Rhizoma Et Radix Notopterygii 6 ~ 15 parts, Herba Houttuyniae 12 ~ 24 parts, Herba Pogostemonis 9 ~ 21 parts, Herba Centipedae 9 ~ 15 parts, 6 ~ 12 parts, Radix Glycyrrhizae.

Prevent and treat a Chinese medicine composition for infectious coryza of chicken, be prepared from by the raw material of following weight portion: Radix Isatidis 15 parts, Flos Chrysanthemi Indici 18 parts, Radix Saposhnikoviae 15 parts, Radix Scutellariae 15 parts, Herba Menthae 9 parts, 9 parts, Herba Ephedrae, Fructus Xanthii 9 parts, Flos Magnoliae 9 parts, the Radix Angelicae Dahuricae 9 parts, Rhizoma Chuanxiong 9 parts, Radix Angelicae Sinensis 6 parts, 6 parts, Flos Carthami, Rhizoma Et Radix Notopterygii 9 parts, Herba Houttuyniae 18 parts, Herba Pogostemonis 15 parts, Herba Centipedae 12 parts, 6 parts, Radix Glycyrrhizae.

Its dosage form is powder.

Prevent and treat a preparation method for the Chinese medicine composition of infectious coryza of chicken, comprise the following steps:

(1) take each raw material, after pulverizing, cross 40-80 mesh sieve;

(2) insert in mixer and stir, fully mix;

(3) pulverize through superfine communication technique, make superfine powder.

The Chinese medicine composition of control infectious coryza of chicken disclosed by the invention, wherein the property of medicine drug effect of each Chinese medicinal components is as follows:

Radix Isatidis: be the root of Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort.; Containing indigo, indirubin and several amino acids, as arginine, glutamic acid etc., also containing various active compositions such as sinigrin, indigo glycosides, couroupitine As; Nature and flavor are bitter, cold, GUIXIN, lung.Liver, stomach warp; Energy heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving; Cure mainly anemopyretic cold, influenza, epidemic encephalitis, encephalitis b, major part pestilence, scarlet fever, wait disease separately; Modern pharmacology proves that Radix Isatidis has antibacterium, antiviral, antiendotoxin, the effect such as anticancer, has regulating action to immune system simultaneously.

Flos Chrysanthemi Indici: the effect with dispelling wind, heat clearing away, improving eyesight, removing toxic substances, the disease such as primary treatment headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, treatment skin ulcer, toxic swelling.Function heat-clearing and toxic substances removing, detumescence.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all antibacterial, antivirus action, all has inhibitory action in various degree to staphylococcus aureus, escherichia coli, diphtheria corynebacterium, dysentery bacterium, bacillus pyocyaneus, Bacillus proteus.

Radix Saposhnikoviae: warm in nature, acrid in the mouth, sweet.Return bladder, liver, spleen channel.The functions such as Radix Saposhnikoviae has inducing diaphoresis to dispel wind, and victory is wet, antipruritic, relieving convulsion, tranquilizing soporific, convulsion, calm, antipyretic, cooling, anticoagulation, antithrombotic suppresses smooth muscle, spasmolytic, immunomodulating, antiinflammatory, antiallergic, antihistamine, the pharmacological actions such as antibacterium.

Radix Scutellariae: cold in nature, bitter in the mouth, returns lung, gallbladder, spleen, large intestine, small intestine meridian; There is heat clearing and damp drying, eliminating fire and detoxication, effect of arresting bleeding and miscarriage prevention.This product tool broad-spectrum antibacterial action, all have bacteriostasis to alpha streptococcus, streptococcus pneumoniae, meningococcus, staphylococcus aureus, diphtheria corynebacterium, vibrio cholera, dysentery bacterium, cattle and sheep pig three type brucella, bacillus pyocyaneus, white scour of chicken bacillus etc., especially to staphylococcus and bacillus pyocyaneus inhibitory action stronger.Also there is inhibitory action to some pathogenic fungus, virus, also have inhibitory or killing effect to leptospira, protozoon etc.Swell for enteritis, pneumonia, brucellosis, influenza, endometritis, conjunctivitis, ophthalmia and inflammation.Also the preventive drug of the white scour of chicken can be used as.Have protect the liver, function of gallbladder promoting, and antiinflammatory, antiallergic, diuresis, calmness, the blood pressure lowering of expansion peripheral blood vessel spoke effect, burnt suppression platelet aggregation.

Herba Menthae: acrid in the mouth, property; Return lung, Liver Channel; Delicate fragrance rises loose; There is wind-dispelling heat-dissipating, refresh oneself, throat, rash, effect of resolving depression; Cure mainly wind heat table disease, have a headache dizzy, conjunctival congestion and swelling pain, pharyngalgia celostomia, nasal sinusitis, toothache, measles without adequate eruption, urticaria pruritus, hypochondriac pain due to stagnation of liverQI gastral cavity is swollen, scrofula tuberculosis.Modern pharmacological research shows that Herba Menthae has 1, antivirus action: aqua methnae decoct 1:20 concentration, has inhibitory action to viral ECHO11 strain.2, analgesia, itching-relieving action: Mentholum mainly makes external use anti pruritic, faint local anaesthesia and counteirritantia, is applied to local and causes cool feeling owing to exciting nerve, and suppress pain nerve.3, irritation, antitussive action: the irritation effect of Mentholum causes trachea to produce new secretion, and make the mucus of stiff be easy to discharge, therefore have phlegm-dispelling functions, also there is report Mentholum to Cavia porcellus and have good antitussive action per capita.4, bactericidal action: Mentholum has very strong bactericidal action, d-Mentholum is stronger than the bacteriostasis of 1-Mentholum.

Herba Ephedrae: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Raw product relieving the exterior syndrome by diaphoresis and inducing diuresis to remove edema power strong, be used for chill exterior syndrome, uncomfortable in chestly breath with cough, edema due to wind pathogen edema, rheumatic arthralgia, carbuncle of yin nature, sucutaneous nodule.Herba ephedrae inclined profit warm in nature, pungent loose perspiration relaxes, and enhances the merit of nourishing the lung to arrest cough, wins with depressed lung-energy dispersing cough-relieving power.Be used for table disease to separate, asthma and cough.The effect of Herba Ephedrae floss relaxes, and is suitable for old man, child and empty people's wind and cold flu.The effect of Herba ephedrae floss more relaxes, be suitable for exterior syndrome separate and breath with cough do not heal old man, the empty patient of child and body.

Fructus Xanthii: acrid in the mouth warm in nature, returns lung, stomach footpath.Because its pungent loose temperature is led to, fragrance is walked to alter, up women's head-ornaments, and kind clearing the nasal passage, because controlling nasosinusitis headache key medicine.As long as suitably its partially cold partial heat of compatibility all can be applied simultaneously, oral administration and externally has good curative effect.Modern pharmacological research, the volatile oil contained by Flos Magnoliae, has calmness, analgesic activity, has astriction, thus protection Bi Dot film, and the absorption of energy Cu Jin Dot film secretions, reduce inflammation, and even nasal cavity is unobstructed.Clinical research proves, Flos Magnoliae preparation is used for bronchia mucosal, can produce one deck coagulum, makes secretion and ooze out minimizing.Meanwhile, due to Marjoram Extract, local blood circulation improves, and can impel again the absorption of secretions.

Flos Magnoliae: nature and flavor: pungent, temperature; Attach to the lung and stomach meridians; Function cures mainly: dispersing wind and cold, clearing the nasal passage.For headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge.1. anemofrigid cold.The pungent loose temperature of this product is led to, energy dispersing wind-cold, a surname's clearing the nasal passage.With controlling affection of exogenous wind-cold, the closing of lung key, fever with aversion to cold, headache nasal obstruction person, can the wind-cold-dispersing medicinal such as compatibility Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Herba Asari.If anemopyretic cold and the headache person that has a stuffy nose, also in the dispelling wind and heat pathogens medicines such as Herba Menthae, Flos Lonicerae, Flos Chrysanthemi, can drink and add this product, to strengthen the power of clearing the nasal passage, loose ailment said due to cold or exposure.2. nasal sinusitis.The pungent temperature of this product is dispersed, awakening consciousness, and its property reaches, external enwergy removing cold and wind pathogen, and interior can liter reaches lung stomach clearing heat in QI system, kind clearing the nasal passage, for controlling the key medicine of nasosinusitis headache, nasal obstruction watery nasal discharge.The hemiplegia person of trembling with fear, dispersing wind and cold, the same use of clearing the nasal passage medicine such as normal and the Radix Angelicae Dahuricae, Herba Asari, Fructus Xanthii, as Fructus Xanthii powder (recipes for Saving Lives); The hot person of hemiplegia, many with Herba Menthae, Fructus Forsythiae, Radix Scutellariae etc. dispelling wind heat, lung-heat clearing away medicine use together.If hot and suffocating of lung stomach is nasal abscess person, can with the clearing away heat-fire antidote compatibilities such as Rhizoma Coptidis, Fructus Forsythiae, Flos Chrysanthemi Indici.

The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth has the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, and effect of detumescence and apocenosis, is used for the treatment of headache, supraorbital bone pain, toothache, nasal sinusitis, and cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Modern pharmacological research antibacterial action: Radix Angelicae Dahuricae decoct all has inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis etc.

Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.For pacifying nerve, positive wind syndrome of head headache, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Radix Angelicae Sinensis: nature and flavor Gan Xinwen, returns liver, the heart, spleen channel; There is blood-supplementing blood-nourishing, promoting blood circulation and stopping pain, effect of relaxing bowel.This product all has potentiation to non-specific and specific immune function, can significantly improve mouse monokaryon cytophagy, to caused by cyclophosphamide immune suppression function tool antagonistic action; The non-dialysis part of Radix Angelicae Sinensis hot water extract is that the generation of polyclone B cell activator antagonist can play strong adjuvant effect, and antibody forming cell's number and antibody titer can be made apparently higher than control animals.Radix Angelicae Sinensis in vivo, externally all can activate diversity mice bone-marrow-derived lymphocyte, directly can also activate and participate in antibody response I and arrest T lymphocyte, have very strong immunological enhancement, also to the generation of IL-2, there is obvious potentiation.

Flos Carthami: warm in nature, acrid in the mouth.Cure mainly latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury.When ancients often have what blood in vivo, often add Flos Carthami tate, available one day twice foot bath boiled by bundle, is suitable for various varicosis, peripheral neuritis, blood circulation.Have a kind of composition of anti-inflammatory activity in Flos Carthami, the inflammation for animal bodies has good inhibitory action.Plurality of active ingredients in Flos Carthami can affect immunity, antagonism paf receptor, improves NO level in body, scavenging activated oxygen, can also the antagonism inflammation factor, effectively good antiinflammatory action.

The diseases such as Rhizoma Et Radix Notopterygii: meridian distribution of property and flavor: acrid, bitter, warm, returns urinary bladder channel, kidney channel effect: the cold expelling that induces sweat, expelling wind and dampness, analgesic use: 1, for affection of exogenous wind-cold, fever with aversion to cold, headache general pain.2, for arthrodynia of extremities, the aching pain in should and back caused by wind-cold damp pathogen invasion and attack.Rhizoma Et Radix Notopterygii also has antiinflammatory and Detoxication, treatment edema due to wind pathogen edema, sore swollen toxin.For enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and the disease such as to breathe heavily.

Herba Houttuyniae: acrid in the mouth, cold.Can heat-clearing and toxic substances removing, row's detumescence treatment skin ulcer, promoting urination to remove dampness, invigorating the stomach and promoting digestion bitterly.With controlling excess-heat, pyretic toxicity, damp, disease heat is the lung abscess, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc. suffered from.Herba Swertiae davidi element is the main antimicrobial component of Herba Houttuyniae, to micrococcus catarrhalis, hemophilus influenza, streptococcus pneumoniae, golden yellow fructus Vitis viniferaecoccuses etc. have obvious inhibitory action.Herba Houttuyniae also containing effective ingredient such as quercitrins, has antiviral and diuresis.Herba Houttuyniae all has good curative effect for upper respiratory tract infection, bronchitis, pneumonia, chronic tracheitis, chronic cervicitis, pertussis etc., also has certain curative effect to acute conjunctivitis, urinary tract infection etc.Herba Houttuyniae can also enhancing human body immunity function, increases leukocytes phagocytic ability, has analgesia, cough-relieving, hemostasis, promotes tissue regeneration, the effect of the aspects such as expansion blood capillary, increase blood flow.

Herba Pogostemonis: nature and flavor are pungent, tepor, return spleen, stomach, lung meridian.Herba Pogostemonis have deliver expelling summer-heat, removing dampness is amusing, the effect of the preventing or arresting vomiting that whets the appetite.Herba Pogostemonis has the effect delivering expelling summer-heat, the nausea and vomiting that treatment sunstroke in summer causes, sweating, and faint, Herba Pogostemonis has the effect delivering expelling summer-heat, the nausea and vomiting that treatment sunstroke in summer causes, and sweating, faints, have good effect.Herba Pogostemonis can also treat the diseases such as energy-stagnation stomachache, has adjustment gastrointestinal function, promotes gastric secretion, strengthens the effect of eupepsy.For flatulence, have a stomach-ache, anorexia, having the hiccups after meal etc. has good pleasant analgesic effect.Herba Pogostemonis also has effect of antidiarrheal to have good curative effect for the abdominal pain diarrhea that enteritis, heatstroke, eating and drinking without temperance cause.Also can be used for the abdominal distention diarrhoea that alimentary toxicosis causes.Also can be used for malaria, dysentery.Its water decoction in vitro has stronger Fungistasis and antibacterial action.

Herba Centipedae: expelling wind and cold, stuffy nose relieving is opened and is stolen, removing toxic substances nebula removing.Herba Centipedae be used for dispeling the wind logically to steal, removing toxic substances and promoting subsidence of swelling.Cure mainly flu; Headache; Nasal sinusitis; Nasal polyp; Cough; Sore throat; Deaf; Conjunctivitis; Malaria; Rheumatic arthralgia; Traumatic injury; Toxic swelling; Scabies.Its volatile oil and alcohol extract part are eliminated the phlegm, cough-relieving, antiasthmatic effect.50% water decoction can suppress the growth of tubercule bacillus, and to experimental strains such as diphtheria corynebacterium, staphylococcus aureus, Staphylococcus albus, first group B streptococcus, Diplococcus pneumoniae, micrococcus catarrhalis, Bacillus typhi, Fu Shi and S. sonnei, escherichia coli, bacillus pyocyaneus all in extremely sensitive.Its distillate has the effect of suppression influenza virus in 1:8400 concentration.

Radix Glycyrrhizae: Radix Glycyrrhizae property is put down, and sweet in the mouth, returns 12 warps.There is removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer.In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, grows and coughs lung moistening, and emergency is detoxified, and is in harmonious proportion hundred medicines.Raw with curing mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.; Processed with honey cures mainly spleen and stomach function and goes down, and large loose stool is thin, weak heating and cough, cardiopalmus etc.Radix Glycyrrhizae has the effect of similar adrenocortical hormone sample, has inhibitory action to the gastroxia that histamine causes; And have antiacid and alleviate the effect of gastrointestinal smooth muscle spasm.Licoflavone, Radix Glycyrrhizae extractum and enoxolone all have obvious antitussive effect; Phlegm-dispelling functions is also more remarkable.Radix Glycyrrhizae also has antiinflammatory, anti-allergic effects, can protect throat and the tunica mucosa tracheae of inflammation.Radix Glycyrrhizae extractum and glycyrrhizic acid have the Detoxication of similar glucuronic acid to some poisonous substance.Contribute to balancing the hormone-content in women's body; Subacid contained by Radix Glycyrrhizae can block the effect of Induced by Carcinogen tumor growth.

In side of the present invention, Fructus Xanthii, Flos Magnoliae are conventional Chinese medicine in cacorhinia treatment, and Fructus Xanthii is kind controls obstructed, ailment said due to cold or exposure headache of having a stuffy nose, for the successive dynasties treat the key medicine of nasal sinusitis and headache, essentials of Matea Medica cloud: " kind diaphoresis, loose rheumatism; above logical brain top; descending sufficient knee joint, reaches skin outward, control headache; order is dark; toothache, nasal sinusitis, deburring ".Its property of Flos Magnoliae reaches, rises and reach clearing heat in QI system, both can enter lung meridian Shan San pulmonary's ailment said due to cold or exposure and clearing the nasal passage, enter again stomach through and draw clear sun in stomach gas on defeated brains have a headache to stop, for controlling the key medicine of cacorhinia headache, be monarch drug; Radix Saposhnikoviae rises and sends out and can fall apart, general for controlling wind, the exterior syndrome caused by ailment said due to cold or exposure, and no matter holding under the arm trembles with fear holds heat under the arm or hold under the arm wet, Radix Saposhnikoviae compatibility Rhizoma Et Radix Notopterygii, with loose exopathogen of dispelling, removes exterior syndrome; The pungent loose temperature of Herba Centipedae is led to, and enter lung meridian, liver channel of foot-Jueyin, its acrid in the mouth is strong, and its property rises loose, can lead to lung meridian, above reach brains, and circulation of qi promoting heresy of faling apart is had one's ideas straightened out, and (Compendium of Materia Medica ": " removing toxic substances ..., control nasal obstruction obstructed ..., skin ulcer of faling apart again is swollen." Herba Pogostemonis is warm in nature and not dry, exterior cold of can faling apart again can removing dampness turbid, " book on Chinese herbal medicine is new again ": " inducing diaphoresis to expel pathogens, dampness removing, except wind, relieves heat and thirst ... can control sore throat, reduce phlegm, cough-relieving is coughed." the pungent perfume (or spice) of the Radix Angelicae Dahuricae walks to alter, causing resuscitation with aromatic drugs, dispel the wind expectorant, sterilization evacuation of pus.For ministerial drug, Radix Scutellariae, Herba Houttuyniae are apt to clearing away lung-heat; The effect of Herba Menthae tool dispelling wind and heat pathogens; Radix Isatidis, Flos Chrysanthemi Indici heat-clearing and toxic substances removing, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami promoting flow of QI and blood are adjuvant drug altogether, the invigorating middle warmer of Radix Glycyrrhizae QI invigorating, heat-clearing and toxic substances removing, are in harmonious proportion the property of medicine for making medicine.

The Chinese medicine composition energy dispelling wind and heat pathogens of control infectious coryza of chicken disclosed by the invention, reduce phlegm dampness removing, stuffy nose relieving is had one's ideas straightened out, and for preventing and treating infectious coryza of chicken, chronic respiratory tract disease, has drug effect fast, effective, cure rate is high, and effect is rapid, and easy to use, cheap, the advantage of drug residue free, and preparation method is simple, is easy to apply.

Detailed description of the invention

Implement 1

Described Chinese medicine composition is powder, and its preparation method, comprises the following steps:

(1) take each raw material, after pulverizing, cross 40 mesh sieves;

(2) insert in mixer and stir, fully mix;

(3) pulverize through superfine communication technique, make superfine powder.

Embodiment 2

(1) take each raw material, after pulverizing, cross 40 mesh sieves;

(2) insert in mixer and stir, fully mix;

(3) pulverize through superfine communication technique, make superfine powder.

Embodiment 3

Prevent and treat a Chinese medicine composition for infectious coryza of chicken, be prepared from by the raw material of following weight portion: Radix Isatidis 9 parts, Flos Chrysanthemi Indici 12 parts, Radix Saposhnikoviae 12 parts, Radix Scutellariae 17 parts, Herba Menthae 13 parts, 8 parts, Herba Ephedrae, Fructus Xanthii 10 parts, Flos Magnoliae 8 parts, the Radix Angelicae Dahuricae 15 parts, Rhizoma Chuanxiong 6 parts, Radix Angelicae Sinensis 7 parts, 8 parts, Flos Carthami, Rhizoma Et Radix Notopterygii 10 parts, Herba Houttuyniae 14 parts, Herba Pogostemonis 9 parts, Herba Centipedae 15 parts, 8 parts, Radix Glycyrrhizae.

(1) take each raw material, after pulverizing, cross 80 mesh sieves;

(2) insert in mixer and stir, fully mix;

(3) pulverize through superfine communication technique, make superfine powder.

Embodiment 4

Prevent and treat a Chinese medicine composition for infectious coryza of chicken, be prepared from by the raw material of following weight portion: Radix Isatidis 12 parts, Flos Chrysanthemi Indici 14 parts, Radix Saposhnikoviae 17 parts, Radix Scutellariae 12 parts, Herba Menthae 18 parts, 10 parts, Herba Ephedrae, Fructus Xanthii 13 parts, Flos Magnoliae 6 parts, the Radix Angelicae Dahuricae 11 parts, Rhizoma Chuanxiong 13 parts, Radix Angelicae Sinensis 9 parts, 9 parts, Flos Carthami, Rhizoma Et Radix Notopterygii 15 parts, Herba Houttuyniae 12 parts, Herba Pogostemonis 12 parts, Herba Centipedae 9 parts, 10 parts, Radix Glycyrrhizae.

(1) take each raw material, after pulverizing, cross 60 mesh sieves;

(2) insert in mixer and stir, fully mix;

(3) pulverize through superfine communication technique, make superfine powder.

Embodiment 5

Prevent and treat a Chinese medicine composition for infectious coryza of chicken, be prepared from by the raw material of following weight portion: Radix Isatidis 18 parts, Flos Chrysanthemi Indici 20 parts, Radix Saposhnikoviae 9 parts, Radix Scutellariae 18 parts, Herba Menthae 15 parts, 12 parts, Herba Ephedrae, Fructus Xanthii 15 parts, Flos Magnoliae 12 parts, the Radix Angelicae Dahuricae 12 parts, Rhizoma Chuanxiong 15 parts, Radix Angelicae Sinensis 8 parts, 7 parts, Flos Carthami, Rhizoma Et Radix Notopterygii 12 parts, Herba Houttuyniae 24 parts, Herba Pogostemonis 18 parts, Herba Centipedae 10 parts, 12 parts, Radix Glycyrrhizae.

(1) take each raw material, after pulverizing, cross 60 mesh sieves;

(2) insert in mixer and stir, fully mix;

(3) pulverize through superfine communication technique, make superfine powder.

Embodiment 6

Prevent and treat a Chinese medicine composition for infectious coryza of chicken, be prepared from by the raw material of following weight portion: Radix Isatidis 10 parts, Flos Chrysanthemi Indici 17 parts, Radix Saposhnikoviae 20 parts, Radix Scutellariae 13 parts, Herba Menthae 10 parts, 6 parts, Herba Ephedrae, Fructus Xanthii 6 parts, Flos Magnoliae 15 parts, the Radix Angelicae Dahuricae 8 parts, Rhizoma Chuanxiong 11 parts, Radix Angelicae Sinensis 7 parts, 8 parts, Flos Carthami, Rhizoma Et Radix Notopterygii 7 parts, Herba Houttuyniae 22 parts, Herba Pogostemonis 10 parts, Herba Centipedae 11 parts, 9 parts, Radix Glycyrrhizae.

(1) take each raw material, after pulverizing, cross 80 mesh sieves;

(2) insert in mixer and stir, fully mix;

(3) pulverize through superfine communication technique, make superfine powder.

Embodiment 7

Prevent and treat a Chinese medicine composition for infectious coryza of chicken, be prepared from by the raw material of following weight portion: Radix Isatidis 16 parts, Flos Chrysanthemi Indici 21 parts, Radix Saposhnikoviae 24 parts, Radix Scutellariae 16 parts, Herba Menthae 6 parts, 7 parts, Herba Ephedrae, Fructus Xanthii 8 parts, Flos Magnoliae 11 parts, the Radix Angelicae Dahuricae 6 parts, Rhizoma Chuanxiong 7 parts, Radix Angelicae Sinensis 6 parts, 6 parts, Flos Carthami, Rhizoma Et Radix Notopterygii 6 parts, Herba Houttuyniae 20 parts, Herba Pogostemonis 21 parts, Herba Centipedae 13 parts, 7 parts, Radix Glycyrrhizae.

(1) take each raw material, after pulverizing, cross 40 mesh sieves;

(2) insert in mixer and stir, fully mix;

(3) pulverize through superfine communication technique, make superfine powder.

With concrete animal clinical study, effect of the present invention is described below:

1. test material

1.1 experimental animal

According to epidemiology, clinical symptoms, pathology cuts open inspection, identification and isolation of pathogen, is that the sick chicken of infective rhinitis adopts BIYANKANG to treat respectively through comprehensive diagnos, and is provided with streptomycin contrast, observe the curative effect, result of calculation and statistical analysis.

1.1.1 infective rhinitis

Clinical symptoms: cough, sneeze, one-sided or bilateral eyelid swelled are shed tears.Pathology cuts open inspection: there is mucus exudate on the hyperemia of nose and paranasal sinuses mucosa and swelling, tracheal strips surface.Identification and isolation of pathogen: extract secretions in sterile working's nasal sinuses, direct streak inoculation in blood agar culture medium, 37 cultivate 24 hours, see have canescence smooth colony to grow; Smear for microscopic examination is the negative dialister bacterium of polarity dyeing.

1.2 trial drug

1.2.1 Chinese medicine composition disclosed by the invention

Be processed into powder by recipe quantity disclosed by the invention and production technology, 200g/ bag, pack for subsequent use.

1.2.2 antibiotic medicine

Streptomycin sulfate, lot number 20110609, specification every bottle 1g (100 million international units), North China Pharmaceutical Factory produces.

2. curative effect judging standard

2.1 rehabilitation recoveries from illness: medication is after 3 days, and clinical disease disappears, and laying hen laying rate is shown in there is rise, pathology cuts open inspection without obvious pathological phenomenon.

2.2 effective medications are after 3 days, and clinical disease disappears substantially, and spirit, diet, amount of drinking water are normal.

2.3 medications are after 3 days, clinical disease with before treatment, even deadly to increase.

3. clinical test results

Send the sick chicken of examining to carry out clinical trial after making a definite diagnosis poultry specialist, time in November, 2011 ~ December, the results are shown in Table one.

Table one

As seen from the above table: this Chinese medicine composition has good therapeutic effect to infectious coryza of chicken, the therapeutic effect of streptomycin sulfate to infectious coryza of chicken is better than; Between this Chinese medicine composition high dose group and middle dosage group, therapeutic effect is through both inspections no significant difference (p > 0.05); Between middle dosage group and low dose group, to the therapeutic effect difference extremely remarkable (p < 0.01) of infectious coryza of chicken.

Clinical expanding test: every 100kg feedstuff adds this Chinese medicine composition 0.5kg, and mixing, is used in conjunction 3 days; Methods for the diagnosis of diseases, curative effect judging standard are identical with clinical trial, 2 ~ July of 2012 time, Dawangzhuang, suburb, Anyang, place chicken house, Kaifeng feed companies chicken farm, poultry specialist of Mangshan Mountain district, Zhengzhou etc.Its statistical result refers to following table two.

Table two

Disease name	Usage and consumption	Treatment chicken number	Cure number	Invalid number	Cure rate %
						Infective rhinitis	0.5% mix fodder, is used in conjunction 3 days	3050	2818	232	92.4

From the above results, add this Chinese medicine composition in 0.5% ratio in feedstuff, be used in conjunction 3 days, infective rhinitis is evident in efficacy in treatment, and cure rate is high, and effect is rapid, and easy to use, cheap.

Adopt 3 multiple doses of usual amounts, namely add in feedstuff in the ratio of 2% by this Chinese medicine composition, result has no chicken any exception, and illustrate that the safety coefficient of this medicine is comparatively large, toxic action is very little.

Claims

1. prevent and treat the Chinese medicine composition of infectious coryza of chicken for one kind, it is characterized in that, be prepared from by the raw material of following weight portion: Radix Isatidis 9 ~ 18 parts, Flos Chrysanthemi Indici 12 ~ 21 parts, Radix Saposhnikoviae 9 ~ 24 parts, Radix Scutellariae 12 ~ 18 parts, Herba Menthae 6 ~ 18 parts, 6 ~ 12 parts, Herba Ephedrae, Fructus Xanthii 6 ~ 15 parts, Flos Magnoliae 6 ~ 15 parts, the Radix Angelicae Dahuricae 6 ~ 15 parts, Rhizoma Chuanxiong 6 ~ 15 parts, Radix Angelicae Sinensis 6 ~ 9 parts, 6 ~ 9 parts, Flos Carthami, Rhizoma Et Radix Notopterygii 6 ~ 15 parts, Herba Houttuyniae 12 ~ 24 parts, Herba Pogostemonis 9 ~ 21 parts, Herba Centipedae 9 ~ 15 parts, 6 ~ 12 parts, Radix Glycyrrhizae.

2. a kind of Chinese medicine composition preventing and treating infectious coryza of chicken according to claim 1, it is characterized in that, be prepared from by the raw material of following weight portion: Radix Isatidis 15 parts, Flos Chrysanthemi Indici 18 parts, Radix Saposhnikoviae 15 parts, Radix Scutellariae 15 parts, Herba Menthae 9 parts, 9 parts, Herba Ephedrae, Fructus Xanthii 9 parts, Flos Magnoliae 9 parts, the Radix Angelicae Dahuricae 9 parts, Rhizoma Chuanxiong 9 parts, Radix Angelicae Sinensis 6 parts, 6 parts, Flos Carthami, Rhizoma Et Radix Notopterygii 9 parts, Herba Houttuyniae 18 parts, Herba Pogostemonis 15 parts, Herba Centipedae 12 parts, 6 parts, Radix Glycyrrhizae.

3. a kind of Chinese medicine composition preventing and treating infectious coryza of chicken according to claim 1 and 2, is characterized in that: its dosage form is powder.

4. a kind of preparation method of preventing and treating the Chinese medicine composition of infectious coryza of chicken according to claim 3, is characterized in that, comprise the following steps:

(1) take each raw material, after pulverizing, cross 40-80 mesh sieve;

(2) insert in mixer and stir, fully mix;

(3) pulverize through superfine communication technique, make superfine powder.