CN103623098B - Externally-applied medicine for treating rhinitis and preparation method thereof - Google Patents

Abstract

The invention discloses an externally-applied medicine for treating rhinitis and a preparation method thereof. The medicine is prepared from the following medicinal materials by weight: 3 to 10 parts of milkvetch root, 10 to 20 parts of siberian cocklebur fruit, 10 to 20 parts of small centipeda herb, 3 to 10 parts of dahurian angelica root, 10 to 20 parts of divaricate saposhnikovia root, 3 to 10 parts of mint, 5 to 10 parts of root of large-flowered skullcap, 3 to 10 parts of Chinese magnoliavine fruit, 5 to 10 parts of Sichuan lovage rhizome, 5 to 10 parts of dodder seed, 10 to 20 parts of flos magnoliae liliflorae, 5 to 10 parts of orange fruit and 5 to 10 parts of spine date seed. The medicine provided by the invention uses herbaceous plants as raw materials and has small toxic and side effects; the medicine can be directly smeared in nasal cavities and rapidly absorbed through the skin, exerts good anti-inflammation and sterilization effects and is fast in ventilation.

Description

A kind of external used medicine for the treatment of rhinitis and preparation method thereof

Technical field

The present invention relates to pharmaceutical formulation field, be specifically related to a kind of external used medicine for the treatment of rhinitis and preparation method thereof.

Background technology

Rhinitis (Rhinitis) is the inflammation of nasal membrane and submucous tissue, shows as hyperemia or edema.Often there is nasal obstruction, snivel, rhinocnesmus, throat's discomfort, the symptoms such as sneeze, cough in patient.It is because acute or chronic nasal mucosa is as virus, courses of infection, or the effect of stimulus object is impaired and cause.Rhinitis not only affects nose, throat and eyes, also can affect sleep, audition, even headache, giddy, inappetence, easy tired, hypomnesis etc.In the time affecting the physiological function of nasal cavity, there will be respiratory disorder, cause blood oxygen and reduce, affect function and the metabolism of other tissue and organ.Rhinitis etiology and pathogenesis mostly is experiences wind heat or wind and cold, enters inner heat-transformation, and the turbid tears resistance of pyretic toxicity is closed nose key and formed.Chronic person is many because of deficiency of the spleen and lung, and insufficiency of lung-QI is to weakened defensive QI, susceptible exopathogen.Insufficiency of the spleen transformation failure of spleen, phlegm-damp is detained, tired knot nose key, contamination sinus mucosa forms nasal sinusitis.Therefore chronic rhinitis is answered lung heat clearing strengthening the spleen.Rhinitis is first due to insufficiency of lung-QI, instability of surface, and wind and cold is taken advantage of a weak point, violate and nose key, and pathogen conflicting with vital QI, lung qi is obstructed, and body fluid stops gathering, sneeze watery nasal discharge; Enriching of lung qi, depends on the defeated cloth of temper, and deficiency of spleen-QI is insufficiency of lung-QI, and the root of gas is at kidney, suffers from a deficiency of the kidney to take the photograph and receives unablely, and gas is not returned unit, and yang-energy is easy to dissipate, and invades and cause a disease in ailment said due to cold or exposure.Therefore, their early stage normal dialectical be the excess syndrome such as wind-cold affecting lung or lung meridian intrinsic heat, along with course advancement, in various degree deficient of internal organs, often dialectical is insufficiency of lung-QI, or lung spleen or deficiency of both the lung and kidney, even the dirty all void of lung spleen kidney three.Nearly ninety percent nasopharyngeal carcinoma is because of due to rhinitis obstinate.Some rhinitis patient's hypertrophic inferior turbinates, oxygen deficiency when sleep, serious caused cerebral infarction, hypertension, heart attack etc., even sudden death.The symptom of rhinitis is to be caused by too high histamine.And what cause that histamine increases is the liquid of these positions secretions.

Summary of the invention

The object of this invention is to provide a kind of medication few, effective fast, determined curative effect, short treating period, medicine of safe and reliable treatment rhinitis and preparation method thereof

For achieving the above object, the present invention adopts following technical scheme:

A kind of external used medicine for the treatment of rhinitis and preparation method thereof, it is formulated by the drug material of following parts by weight: Radix Astragali 3-10 part, Fructus Xanthii 10-20 part, Herba Centipedae 10-20 part, Radix Angelicae Dahuricae 3-10 part, Radix Saposhnikoviae 10-20 part, Herba Menthae 3-10 part, Radix Scutellariae 5-10 part, Fructus Schisandrae Chinensis 3-10 part, Rhizoma Chuanxiong 5-10 part, Semen Cuscutae 5-10 part, Flos Magnoliae 10-20 part and Fructus Aurantii 5-10 part, Semen Ziziphi Spinosae 5-10 part;

Its preparation method is: (by weight)

Step 1: fetch water 82 parts, 4 parts of glycerol, xanthan gum 1 part (after dissolving in advance) are mixed and heated to 80 degree, sterilizing;

Step 2: get 4 parts of emulsifying agents, 3 points of spermaceti stearyl alcohols, 2 parts of squalanes, 2 parts of Palmic acid isooctyls, 2 parts, sad certain herbaceous plants with big flowers acid glycerol three fat, is mixed and heated to 80 degree, sterilizing;

Step 3: by step 1 gained solution and the homogeneous 30-35 minute of step 2 gained solution mixing constant temperature to 80 degree;

Step 4: step 3 gained solution is cooled to 60 degree, heats the Azelaic Acid of 1 part, stir and continue cooling, be cooled to below 50 degree;

Step 5: get 6 parts of 6 parts of the Radixs Astragali, 15 parts of Fructus Xanthii, 10 parts of Herba Centipedae, 4 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Saposhnikoviaes, 4 parts of Herba Menthaes, 6 parts of Radix Scutellariaes, 4 parts of Fructus Schisandrae Chinensis, 10 parts of Rhizoma Chuanxiongs, 9 parts of Semen Cuscutae, 10 parts of Flos Magnoliae, 6 parts of Fructus Aurantiis and Semen Ziziphi Spinosaes, be ground into 100-120 order, obtain powder;

Step 6: step 5 gained powder is added in step 4 gained solution, continue to stir, be cooled to 38 degree and stop stirring;

Step 7: by step 6 gained solution left standstill, inspection, fill, gets product.

Effect of each taste medicine and effect:

The Radix Astragali: Radix Astragali sweet in the mouth, slightly warm in nature, returns liver, spleen, lung, kidney channel.There is effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.In traditional Chinese medical science five elements theory, what spring was corresponding is liver, therefore, takes good care of irritability most important for the health preserving in spring.The Radix Astragali, as QI invigorating good merchantable brand, can play certain QI invigorating effect in the season of hair growth promoting in spring.The Radix Astragali soup of cooking gruel, has effect of beneficial blood QI invigorating.

Fructus Xanthii: the acrid in the mouth wind that falls apart, bitter dampness is turbid, understand things pain-stopping, gentle dredging reaches, for headche due to wind-cold, nasosinusitis headache, anosmia, time flow turbid tears, rubella pruritus, arthralgia chiefly caused by damp pathogen contracture.Fructus Xanthii is used for the treatment of acute and chronic rhinitis taking parched medicinal material as good.

Herba Centipedae:; Warm in nature.Return lung, Liver Channel.Dispel the wind logical steal, removing toxic substances and promoting subsidence of swelling, cold expelling, victory is wet, removing nebula, stuffy nose relieving plug.Cure mainly: flu, headache, nasal sinusitis, nasal polyp, cough, sore throat, deafness, conjunctivitis, malaria, rheumatic arthralgia, traumatic injury, toxic swelling, scabies.Have antibacterial, cough-relieving, relieving asthma, anticancer, antiallergic action etc.

The Radix Angelicae Dahuricae: dispersing wind-cold, removing dampness stuffy nose relieving, warm-dryness syndrome dehumidifying, detumescence and apocenosis, the pain relieving of kind energy.Can control ulcer sores, skin pruritus due to dryness, scabies.Radix Angelicae Dahuricae stimulating central nervous system, can make increased blood pressure, antipyretic-antalgic, antiinflammatory, antibacterial, and Radix Angelicae Dahuricae water decoction all has certain inhibitory action to multiple bacterium, can treat vitiligo; Hemostasis; Contact dermatitis is had to obvious inhibitory action etc.

Radix Saposhnikoviae: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly: affection of exogenous wind-cold; Headache general pain; Rheumatic arthralgia; Joint is ached; Stomachache is had loose bowels; Discharging fresh blood stool; Tetanus; Rubella pruritus; Skin infection from the beginning of.

Radix Scutellariae: main effective ingredient: flavone compound.Mainly the compositions such as baicalin, baicalin, wogonin, wogonoside, neobaicalein, cupreol.Hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.There is heat clearing and damp drying, removing pathogenic heat from blood and toxic substance from the body effect.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.Can antipathogen, antiinflammatory, adjusting immunologic function, antipyretic, calm, protect the liver, function of gallbladder promoting etc.Can also blood fat reducing, atherosclerosis, antioxidation, blood pressure lowering, blood fat reducing.Its antimicrobial spectrum is wider, and various bacteria, dermatophytes etc. are had to inhibitory action.Even if the staphylococcus aureus that the antibiotic such as penicillin are developed immunity to drugs is still very sensitive to Radix Scutellariae.Radix Scutellariae also has blood pressure lowering, calmness, diuresis, protects the liver, function of gallbladder promoting, antiallergic, releasing smooth muscle spasm, the effect such as anticancer.

Fructus Schisandrae Chinensis: astringe the lung, nourishing kidney, promotes the production of body fluid, receives antiperspirant, arresting seminal emission.Control the deficiency of the lung and breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Astringing lung-QI and relieving cough: the void for deficiency of both the lung and kidney is coughed, panted, normal and kidney-reinforcing drug share.Arresting seminal emission antidiarrheal: for seminal emission, chronic diarrhea.Control seminal emission and often join Ootheca Mantidis, Os Draconis (calcined); Control chronic diarrhea and often join Semen Myristicae, Semen Euryales.

Arresting sweating promotes the production of body fluid:, night sweat thirsty for the xerostomia of YIN-fluid being insufficient, often join Radix Ophiopogonis, Concha Ostreae.The shock of all QI and blood dissipation, collapse, all can join tonic and use it

Rhizoma Chuanxiong: medicine first choice for the treatment of headache.Menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; Ulcer sores.

Semen Cuscutae: effect of the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, solid tire stopping leak.

Flos Magnoliae: Flos Magnoliae is containing volatile oil and alkaloid.Acrid in the mouth, warm in nature.Attach to the lung and stomach meridians.There is dispersing wind and cold, the functions such as clearing the nasal passage.For headche due to wind-cold, nasal obstruction, nasal sinusitis, allergic rhinitis, stuffy nose nasal abscess, and nasal abscess after pox, turbid nasal discharge etc.Volatile oil has the effect of the nasal mucosa vessels of contraction; 6 alcohol of shutting out have antihistaminic effect.

Fructus Aurantii: dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.

Semen Ziziphi Spinosae: sweet in the mouth, acid, property is flat.Can nourish conscience, calm the nerves, arresting sweating.

The present invention herbaceous plant of drawing materials, toxic and side effects is little; Can be directly outer smearing in nasal cavity, absorbs rapidly by skin, and anti-inflammation and sterilization is effective, and ventilation is fast, medication is few, price is low, effective, determined curative effect, medicine source is abundant, make simple, short treating period, expense is low, safe and reliable.

Brief description of the drawings

Fig. 1 is process flow diagram of the present invention.

Detailed description of the invention

In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.

This detailed description of the invention is by the following technical solutions: a kind of external used medicine for the treatment of rhinitis and preparation method thereof, and it is formulated by the drug material of following parts by weight: Radix Astragali 3-10 part, Fructus Xanthii 10-20 part, Herba Centipedae 10-20 part, Radix Angelicae Dahuricae 3-10 part, Radix Saposhnikoviae 10-20 part, Herba Menthae 3-10 part, Radix Scutellariae 5-10 part, Fructus Schisandrae Chinensis 3-10 part, Rhizoma Chuanxiong 5-10 part, Semen Cuscutae 5-10 part, Flos Magnoliae 10-20 part and Fructus Aurantii 5-10 part, Semen Ziziphi Spinosae 5-10 part;

As shown in Figure 1, its preparation method is: (by mass percentage)

Step 1: fetch water 82 parts, 4 parts of glycerol, xanthan gum 1 part (after dissolving in advance) are mixed and heated to 80 degree, sterilizing;

Step 2: get 4 parts of emulsifying agents, 3 points of spermaceti stearyl alcohols, 2 parts of squalanes, 2 parts of Palmic acid isooctyls, 2 parts, sad certain herbaceous plants with big flowers acid glycerol three fat, is mixed and heated to 80 degree, sterilizing;

Step 3: by step 1 gained solution and the homogeneous 30-35 minute of step 2 gained solution mixing constant temperature to 80 degree;

Step 4: step 3 gained solution is cooled to 60 degree, heats the Azelaic Acid of 1 part, stir and continue cooling, be cooled to below 50 degree;

Step 5: get 6 parts of 6 parts of the Radixs Astragali, 15 parts of Fructus Xanthii, 10 parts of Herba Centipedae, 4 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Saposhnikoviaes, 4 parts of Herba Menthaes, 6 parts of Radix Scutellariaes, 4 parts of Fructus Schisandrae Chinensis, 10 parts of Rhizoma Chuanxiongs, 9 parts of Semen Cuscutae, 10 parts of Flos Magnoliae, 6 parts of Fructus Aurantiis and Semen Ziziphi Spinosaes, be ground into 100-120 order, obtain powder;

Step 6: step 5 gained powder is added in step 4 gained solution, continue to stir, be cooled to 38 degree and stop stirring;

Step 7: by step 6 gained solution left standstill, inspection, fill, gets product.

The present invention herbaceous plant of drawing materials, toxic and side effects is little; Can be directly outer smearing in nasal cavity, absorbs rapidly by skin, and anti-inflammation and sterilization is effective, and ventilation is fast, medication is few, price is low, effective, determined curative effect, medicine source is abundant, make simple, short treating period, expense is low, safe and reliable.

The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.

Claims (1)

1. an external used medicine for the treatment of rhinitis, is characterized in that: it is formulated by the drug material of following parts by weight: 6 parts of 6 parts of the Radixs Astragali, 15 parts of Fructus Xanthii, 10 parts of Herba Centipedae, 4 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Saposhnikoviaes, 4 parts of Herba Menthaes, 6 parts of Radix Scutellariaes, 4 parts of Fructus Schisandrae Chinensis, 10 parts of Rhizoma Chuanxiongs, 9 parts of Semen Cuscutae, 10 parts of Flos Magnoliae, 6 parts of Fructus Aurantiis and Semen Ziziphi Spinosaes;

Its preparation method is by weight:

Step 1: fetch water 82 parts, 4 parts of glycerol, 1 part of xanthan gum, after dissolving in advance, be mixed and heated to 80 degree, sterilizing;

Step 2: get 4 parts of emulsifying agents, 3 points of spermaceti stearyl alcohols, 2 parts of squalanes, 2 parts of Palmic acid isooctyls, 2 parts, sad certain herbaceous plants with big flowers acid glycerol three fat, is mixed and heated to 80 degree, sterilizing;

Step 3: by step 1 gained solution and the homogeneous 30-35 minute of step 2 gained solution mixing constant temperature to 80 degree;

Step 4: step 3 gained solution is cooled to 60 degree, heats the Azelaic Acid of 1 part, stir and continue cooling, be cooled to below 50 degree;

Step 5: get 6 parts of 6 parts of the Radixs Astragali, 15 parts of Fructus Xanthii, 10 parts of Herba Centipedae, 4 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Saposhnikoviaes, 4 parts of Herba Menthaes, 6 parts of Radix Scutellariaes, 4 parts of Fructus Schisandrae Chinensis, 10 parts of Rhizoma Chuanxiongs, 9 parts of Semen Cuscutae, 10 parts of Flos Magnoliae, 6 parts of Fructus Aurantiis and Semen Ziziphi Spinosaes, be ground into 100-120 order, obtain powder;

Step 6: step 5 gained powder is added in step 4 gained solution, continue to stir, be cooled to 38 degree and stop stirring;

Step 7: by step 6 gained solution left standstill, inspection, fill, gets product.