CN103656048B - Medicine being used for the treatment of mammitis of cow and preparation method thereof - Google Patents
Medicine being used for the treatment of mammitis of cow and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of medicine being used for the treatment of mammitis of cow and preparation method thereof, medicine comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, Phtheirospermum tenuisectum Bur.et Franch., Radix Angelicae Sinensis, Herba Lactucae formosanae, Rhizoma Et Radix Notopterygii, Radix Isatidis, Rhizoma Chuanxiong, meropodium pearl, parthenocissus, Pericarpium Citri junoris, bodhi perfume, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Caulis Akebiae, Rhizoma Cyperi, Colla Corii Asini, Radix et Caulis Opuntiae Dillenii, Lagerstroemia indica L., Pericarpium Citri Reticulatae, Semen Euryales, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata and Fructus Crataegi.The invention has the beneficial effects as follows: the present invention is active for primary treatment principle with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dysmenorrhea, provide a kind of medicine being used for the treatment of mammitis of cow, immunity and the resistance against diseases of milch cow can be improved, there is good effect, not easily recur, toxic and side effects is little, the advantage of noresidue; Wherein, medicine of the present invention comprises Oral preparation and medicinal external emulsifiable paste, and the common therapeutic effect that uses is more excellent.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of medicine being used for the treatment of mammitis of cow and preparation method thereof.
Background technology
Mammitis of cow is the inflammation of mammary glandular cell and mammary gland interstitial.Cause the pathogen of breast inflammation, about 85% is streptococcus, micrococcus scarlatinae etc., and 5% is staphylococcus.Other have tubercule bacillus, Brucella, corynebacterium pyogenes, escherichia coli, mycoplasma and mycete etc.The economic loss that mammitis of cow causes is very large, is first that milk yield reduces, is secondly that disease breast can not be drunk, even gives people's communicate illness, work the mischief to people ' s health.If mastitis can not be treated in time, often make mastatrophy, milk can not be sold, and even completely loses Lactation.Therefore the work of control mastitis will be performed.
At present, many employing antibiotic therapy mammitis of cow, therapeutic effect is undesirable, and drug tolerant bacteria also by milk-born infection to people, antibiotic residual in milch cow in addition also can bring out human body generation allergy, and therefore, the non-antibiotic therapy of mammitis of cow causes the concern of people gradually.
Be conceived to entirety during the traditional Chinese medicine application of China, emphasize to regulate allomeric function, improve the premunition of body self.Chinese medicine belongs to natural drug, has antibacterial, antiinflammatory, not easily makes pathogenic bacterium produce the effect of drug resistance and immunostimulant, has the feature of safety, efficient, low toxicity, low-residual, can overcome a large amount of drawback using antibiotic to bring; Chinese herbal medicine has enhancing human body immunity function, improves animal anti-stress, anti-disease ability, improves the multiple efficacies such as breeding performonce fo animals, and have no drug resistance, noresidue, toxic and side effects be little, demonstrates unique advantage in livestock and poultry cultivation.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of mammitis of cow and preparation method thereof, adopt the treatment of this medicine to mammitis of cow to have curative effect is high, toxic and side effects is little, noresidue, do not develop immunity to drugs, non-environmental-pollution the advantage of Abwehrkraft des Koepers and short treating period can be increased.
In order to realize foregoing invention object, the invention provides a kind of medicine being used for the treatment of mammitis of cow, it is characterized in that, described medicine comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, Phtheirospermum tenuisectum Bur.et Franch., Radix Angelicae Sinensis, Herba Lactucae formosanae, Rhizoma Et Radix Notopterygii, Radix Isatidis, Rhizoma Chuanxiong, meropodium pearl, parthenocissus, Pericarpium Citri junoris, bodhi perfume, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Caulis Akebiae, Rhizoma Cyperi, Colla Corii Asini, Radix et Caulis Opuntiae Dillenii, Lagerstroemia indica L., Pericarpium Citri Reticulatae, Semen Euryales, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata and Fructus Crataegi.
Described medicine is made up of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Herba Lactucae formosanae 15-25 weight portion, Rhizoma Et Radix Notopterygii 10-25 weight portion, Radix Isatidis 10-16 weight portion, Rhizoma Chuanxiong 13-20 weight portion, meropodium pearl 10-15 weight portion, parthenocissus 10-15 weight portion, Pericarpium Citri junoris 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Caulis Akebiae 10-15 weight portion, Rhizoma Cyperi 10-15 weight portion, Colla Corii Asini 10-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Lagerstroemia indica L. 10-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Semen Euryales 10-15 weight portion, Endothelium Corneum Gigeriae Galli 10-15 weight portion, Massa Medicata Fermentata 15-20 weight portion and Fructus Crataegi 10-15 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, Herba Lactucae formosanae 18-22 weight portion, Rhizoma Et Radix Notopterygii 15-20 weight portion, Radix Isatidis 12-14 weight portion, Rhizoma Chuanxiong 15-18 weight portion, meropodium pearl 12-14 weight portion, parthenocissus 12-14 weight portion, Pericarpium Citri junoris 13-18 weight portion, the fragrant 16-18 of bodhi measures part, Radix Glycyrrhizae 15-18 weight portion, Radix Et Caulis Acanthopanacis Senticosi 13-18 weight portion, Caulis Akebiae 11-14 weight portion, Rhizoma Cyperi 12-14 weight portion, Colla Corii Asini 11-14 weight portion, Radix et Caulis Opuntiae Dillenii 11-14 weight portion, Lagerstroemia indica L. 12-18 weight portion, Pericarpium Citri Reticulatae 12-17 weight portion, Semen Euryales 11-14 weight portion, Endothelium Corneum Gigeriae Galli 11-14 weight portion, Massa Medicata Fermentata 17-19 weight portion and Fructus Crataegi 12-14 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portion, Radix Codonopsis 15 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portion, Radix Angelicae Sinensis 15 weight portion, Herba Lactucae formosanae 20 weight portion, Rhizoma Et Radix Notopterygii 17 weight portion, Radix Isatidis 13 weight portion, Rhizoma Chuanxiong 17 weight portion, meropodium pearl 13 weight portion, parthenocissus 13 weight portion, Pericarpium Citri junoris 15 weight portion, the fragrant 17 amount parts of bodhi, Radix Glycyrrhizae 16 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Caulis Akebiae 12 weight portion, Rhizoma Cyperi 13 weight portion, Colla Corii Asini 12 weight portion, Radix et Caulis Opuntiae Dillenii 13 weight portion, Lagerstroemia indica L. 15 weight portion, Pericarpium Citri Reticulatae 14 weight portion, Semen Euryales 13 weight portion, Endothelium Corneum Gigeriae Galli 13 weight portion, Massa Medicata Fermentata 18 weight portion and Fructus Crataegi 13 weight portion.
Described medicine also comprises: Formica fusca, Radix Bupleuri, Ganoderma and Radix Rhodiolae.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Herba Lactucae formosanae 15-25 weight portion, Rhizoma Et Radix Notopterygii 10-25 weight portion, Radix Isatidis 10-16 weight portion, Rhizoma Chuanxiong 13-20 weight portion, meropodium pearl 10-15 weight portion, parthenocissus 10-15 weight portion, Pericarpium Citri junoris 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Caulis Akebiae 10-15 weight portion, Rhizoma Cyperi 10-15 weight portion, Colla Corii Asini 10-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Lagerstroemia indica L. 10-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Semen Euryales 10-15 weight portion, Endothelium Corneum Gigeriae Galli 10-15 weight portion, Massa Medicata Fermentata 15-20 weight portion, Fructus Crataegi 10-15 weight portion, Formica fusca 10-16 weight portion, Radix Bupleuri 15-20 weight portion, Ganoderma 10-15 weight portion and Radix Rhodiolae 10-15 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, Herba Lactucae formosanae 18-22 weight portion, Rhizoma Et Radix Notopterygii 15-20 weight portion, Radix Isatidis 12-14 weight portion, Rhizoma Chuanxiong 15-18 weight portion, meropodium pearl 12-14 weight portion, parthenocissus 12-14 weight portion, Pericarpium Citri junoris 13-18 weight portion, the fragrant 16-18 of bodhi measures part, Radix Glycyrrhizae 15-18 weight portion, Radix Et Caulis Acanthopanacis Senticosi 13-18 weight portion, Caulis Akebiae 11-14 weight portion, Rhizoma Cyperi 12-14 weight portion, Colla Corii Asini 11-14 weight portion, Radix et Caulis Opuntiae Dillenii 11-14 weight portion, Lagerstroemia indica L. 12-18 weight portion, Pericarpium Citri Reticulatae 12-17 weight portion, Semen Euryales 11-14 weight portion, Endothelium Corneum Gigeriae Galli 11-14 weight portion, Massa Medicata Fermentata 17-19 weight portion, Fructus Crataegi 12-14 weight portion, Formica fusca 12-14 weight portion, Radix Bupleuri 16-19 weight portion, Ganoderma 11-13 weight portion and Radix Rhodiolae 11-14 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portion, Radix Codonopsis 15 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portion, Radix Angelicae Sinensis 15 weight portion, Herba Lactucae formosanae 20 weight portion, Rhizoma Et Radix Notopterygii 17 weight portion, Radix Isatidis 13 weight portion, Rhizoma Chuanxiong 17 weight portion, meropodium pearl 13 weight portion, parthenocissus 13 weight portion, Pericarpium Citri junoris 15 weight portion, the fragrant 17 amount parts of bodhi, Radix Glycyrrhizae 16 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Caulis Akebiae 12 weight portion, Rhizoma Cyperi 13 weight portion, Colla Corii Asini 12 weight portion, Radix et Caulis Opuntiae Dillenii 13 weight portion, Lagerstroemia indica L. 15 weight portion, Pericarpium Citri Reticulatae 14 weight portion, Semen Euryales 13 weight portion, Endothelium Corneum Gigeriae Galli 13 weight portion, Massa Medicata Fermentata 18 weight portion, Fructus Crataegi 13 weight portion, Formica fusca 13 weight portion, Radix Bupleuri 17 weight portion, Ganoderma 12 weight portion and Radix Rhodiolae 13 weight portion.
In order to better realize foregoing invention object, present invention also offers a kind of preparation method being used for the treatment of the medicine of mammitis of cow, described preparation method comprises the following steps:
The first step, is mixed in proportion all raw medicinal materials, is ground into 100 order ~ 200 object powder, add the water relative to mixture quality 3 ~ 5 times, at the temperature of 90 DEG C ~ 100 DEG C, decoct 30 minutes ~ 1 hour, decoction liquor is filtered, and obtains the first filtrate and filtering residue;
Second step, adds the water relative to first step mixture quality 1 ~ 3 times by the filtering residue that the first step obtains, at the temperature of 90 DEG C ~ 100 DEG C, decocts 30 minutes ~ 1 hour, and decoction liquor is filtered, and obtains the second filtrate;
3rd step, the first filtrate and the second filtrate are merged, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer dry, ensure that inlet temperature is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, is ground into 200 order ~ 400 orders subsequently, obtains drug powder.
In order to better realize foregoing invention object, present invention also offers a kind of preparation method being used for the treatment of the medicine of mammitis of cow, described medicine is emulsifiable paste, and described preparation method is:
Take all raw medicinal materials by weight and soak 1-2 hour, be then placed in multi-function extractor, first time decocts 5-10 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 5-10 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C, cooling; The Margarita powder getting extractum weight 10% adds in extractum, stirs, tinning after ultraviolet radiation sterilizing.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the present invention is active for primary treatment principle with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dysmenorrhea, provide a kind of medicine being used for the treatment of mammitis of cow, immunity and the resistance against diseases of milch cow can be improved, there is good effect, not easily recur, toxic and side effects is little, the advantage of noresidue; Wherein, medicine of the present invention comprises Oral preparation and medicinal external emulsifiable paste, and the common therapeutic effect that uses is more excellent.
Detailed description of the invention
Mammitis of cow symptom is the inflammation of mammary parenchyma, interstitial.The cause of disease is many caused by mechanical irritation, pathogenic microorganism immersion and chemicals rationality are damaged.1. environmental management factor: environmental condition is as muddy in cowshed, cattle bed and sports ground can't bear, and around cattle body and breast, dirty is too many, and sanitary condition is too poor, too high (more than 36 DEG C) of temperature or too low (less than-5 DEG C) etc.Milking conditions does not meet lactogenic physiological requirement, as too high in negative pressure of vacuum, too low, and unsuitable scouring breast and embarkation are milked.2. pathogenic infection: up to the present, people have isolated 150 kinds of pathogenic microorganisms from cow mammary gland tissue, and modal have 23 kinds, wherein 14 kinds, antibacterial, mycoplasma 2 kinds, fungus and 7 kinds, virus.What wherein sickness rate was the highest is staphylococcus aureus, escherichia coli, streptococcus, and mycoplasma, fungus-caused mastitis sickness rate rise year by year in recent years.3. cattle oneself factor: be in lactogenic and contain phase or the too high milch cow of milk production, body energy is in negative balance resistance, aged cattle, polyembryony time cattle relative incidence rate are high.4. secondary factors: the author finds the babesiasis of milch cow in clinical treatment in recent years, also can become the paathogenic factor of mammitis of cow, and treatment is got up also very difficult.There is puerperal infection also can cause mastitis occurs again.For this reason, first protopathy should be controlled after Secondary cases mastitis being made a definite diagnosis.
Mammitis of cow can be divided into serosity mastitis, cellulosic mucositis mastitis, suppurative mastitis, hemorrhagic mastitis, gangrenous mastitis and latent mammitis.Clinic mastitis: be the inflammation of breast interstitial, essence or interstitial parenchymal tissue.It is characterized in that milk degeneration, breast tissue presents swelling, warm and pain to some extent.Different with coincident with severity degree of condition according to course of disease length, can the most acute, acute, subacute and chronic mammitis be divided into.The most acute: suddenly, development rapidly, is multiplely born in 1 Ge Ru district in morbidity; Latent mammitis: also known as Subclinical mastitis.For a kind of mastitis showed without clinical symptoms.It is characterized in that breast and milk without naked eyes as seen extremely, but milk changes on physicochemical property, bacteriology.Concrete manifestation pH value more than 7.0, in meta-alkalescence; Lump in breast, floccule, fiber is had in breast; Sodium chloride content is more than 0.14%, and somatic number is at 500,000/more than mL, and bacterial population and electric conductivity value increase; Chronic cases: because mammary gland tissue is progressive inflammation process, lactogenic acinus wrecks in a big way, and mammary gland tissue generation fibrosis, often causes mastatrophy and induration of breast.
Chinese veterinarian's traditional theory is thought, mastitis and acute mastitis, is expectorant, wet, gas, blood stagnation knot is loose and be scorching.Because feeding and management is not good at, the ground that lying on bed for a long time is damp and hot, damp and hot poison steams, infringement breast; Or because of excessiveness of stomach-heat, stagnation of QI due to depression of the liver, newborn network loses smooth so that breast coagulation of QI-blood, stasis and raw carbuncle; Or inhale breast because of calf, milk is stagnated, reasons such as breast distension and cause primary disease.Therefore, the present invention invigorates blood circulation with heat-clearing and toxic substances removing, dredging collateral, reducing swelling and alleviating pain, active lactogenesis are Therapeutic Principle, provide a kind of medicine being used for the treatment of mammitis of cow, medicine comprises: the Radix Astragali, Radix Codonopsis, Phtheirospermum tenuisectum Bur.et Franch., Radix Angelicae Sinensis, Herba Lactucae formosanae, Rhizoma Et Radix Notopterygii, Radix Isatidis, Rhizoma Chuanxiong, meropodium pearl, parthenocissus, Pericarpium Citri junoris, bodhi perfume, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Caulis Akebiae, Rhizoma Cyperi, Colla Corii Asini, Radix et Caulis Opuntiae Dillenii, Lagerstroemia indica L., Pericarpium Citri Reticulatae, Semen Euryales, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata and Fructus Crataegi.
Wherein, the pharmacological property of each raw medicinal material is as follows:
The Radix Astragali: based on tonify deficiency, energy invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cave in for insufficiency of vital energy and blood, skin infection, difficulty in discharging of pus or burst for a long time and do not hold back person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and the immunologic function of energy enhancing body, therefore can also be used for the generation preventing some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rush down YIN-fire, remove lung-heat, lossless, sends out, and has antiperspirant then to stop." be the good medicine promoting resistance and defence disease.
Radix Codonopsis: property is put down, sweet in the mouth, micro-acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst." book on Chinese herbal medicine justice " carries: Radix Codonopsis power energy spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting, and gas in tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, then spleen invigorating fortune and not dry, grow stomach-Yin and not wetting, lung moistening and do not violate cold and cool, nourishes blood and partially do not grow greasy, inspiring clear sun, gas in vibration, and without just dry fraud.Radix Astragali QI invigorating, can enriching spleen-QI be risen, again can lung benefiting consolidating superficial resistance.Radix Codonopsis QI invigorating, can only spleen invigorating QI invigorating, and without the power of consolidating superficial resistance, but Radix Codonopsis can also supplementing QI for promoting the production of body fluid, and the Radix Astragali is then without the effect of promoting the production of body fluid, and the Radix Astragali is held concurrently can diuretic, and Radix Codonopsis is without diuretic effect.This two tastes medicine share can invigorating the spleen and replenishing QI, improves resistance.
Phtheirospermum tenuisectum Bur.et Franch.: property is put down, acrid in the mouth is bitter.Function cures mainly: tranquilizing by nourishing the heart, hemostasis.Control and have a weak heart, cardiopalmus, cough sputum mixed with blood.Heat-clearing and toxic substances removing, tranquilizing by nourishing the heart, pain relieving.For having a weak heart, cardiopalmus, cough, sputum mixed with blood, laryngopharynx swelling and pain, fracture; Serpentis, lyssodexis are controlled in external.
Radix Angelicae Sinensis: sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Herba Lactucae formosanae: bitter in the mouth; Cold in nature, function cures mainly: heat-clearing and toxic substances removing; Wind-damp dispelling; Invigorate blood circulation.Main furuncle carbuncle; Laryngopharynx swelling and pain; Scabies; Hemorrhoid; Venom; Rheumatic arthralgia; Traumatic injury.
Rhizoma Et Radix Notopterygii: return bladder; Kidney channel.Nature and flavor: acrid in the mouth; Bitter; Warm in nature.Loose exterior cold; Wind-damp dispelling; Profit joint; Pain relieving.Loose exterior cold, wind-damp dispelling, sharp joint.Cure cold wind and cold, has a headache lossless, anemofrigid-damp arthralgia, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema, skin sore.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.Induce sweat cold expelling, expelling wind and dampness, pain relieving.For affection of exogenous wind-cold, fever with aversion to cold, the cards such as headache general pain.This product has stronger dispersing wind-cold and analgesic effect.Often be equal to use with Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Herba Asari, as Notoptreygium Decoction of Nine Ingredients.For arthrodynia of extremities, aching pain in should and back caused by wind-cold damp pathogen invasion and attack, outstanding above hemialgia is more applicable.This product can be dispeled the wind and be won temperature, dispersing cold for relieving pain.Normal and Radix Saposhnikoviae, same to use, as JUANBI TANG." property of medicine opinion ": " control harmful wind, aphonia in silence, blood leprosy of itching, hands and feet caused by paralysis, the askew heresy of actinal surface, insensitive impediment all over more." " Japan hanako materia medica ": " control a wind cutting and gas, muscles and bones fist contraction, extremity are thin bad, and head revolves the red pain of eyes and fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times aqueous vapor, five kinds of strain and seven kinds of impairment, deficient cold air, joint ache, tonneau the five internal organs." " pearl sac ": " Taiyang channel is had a headache, and removes all arthralgias, also can warm gallbladder." " product remittance essence is wanted ": " and main all joints being painful all over, flesh table eight winds coming from eight orientations harmful climatic factors, except new and old rheumatism, row's slough cellulitis skin ulcer." essentials of Matea Medica: " eliminating pathogen in the liver gas, searches liver-wind, and dispelling the wind and dampness pathogens is fought mutually, and herbal classic (sun) is had a headache, and governor vessel is disease, back rigidity and fainting, and tonic convulsion rigidity with sweating, aphasia due to apoplexy, head revolves conjunctival congestion." " about can cure mirror ": " control heresy and close the loathing of cold, high fever is lossless.”
Radix Isatidis: resisting pathogenic microbes effect: Radix Isatidis has inhibitory action to various bacteria.Infusion has inhibitory action in various degree to bacillus subtilis, staphylococcus aureus, sarcine, escherichia coli, Bacillus typhi, Salmonella paratyphi, dysentery (will congratulate, Fu Shi) bacillus, bacillus enteritidis etc.; Acetone leachate also has similar effect, and to Hemolytic streptococcus effectively (all using agar aperture flat band method).Similar to the bacteriostasis of A type meningococcus and Bulbus Allii, Flos Lonicerae.Infected by influenza PR8 strain and Jing Ke 68-1 strain have obvious inhibitory action.In vitro leptospiral effect killed by Radix Isatidis.To cardiovascular effect: these product can make the in vitro rabbit ear and rat lower limb perfusion flow increase, and improve Rabbit Mesentery microcirculation, reduce the blood pressure of Anaesthetic Rabbits, reduce capillary permeability, and make mouse cardiac muscle oxygen consumption decline.Anticoagulant effect Radix Isatidis has remarkable inhibitory action to the Platelet Aggregation in Rabbits that ADP induces.From Radix Isatidis, get uridnine, hypoxanthine, pyrimidine, salicylic acid etc. also all show certain inhibit activities to the Platelet Aggregation in Rabbits that ATP induces, when 0.21mg/kg concentration, its suppression ratio is respectively 18.2%, 24.2%, 10.8% and 20%.Detoxication: dog Radix Isatidis, Rhizoma Coptidis powder and Rhizoma et radix veratri (Radix Rhizoma Veratri), with taking (each 2.0g/kg), can separate Rhizoma et radix veratri (Radix Rhizoma Veratri) poison, reduces mortality rate; If again with it after veratrum poisoning, then invalid; Alone Radix Isatidis powder or Rhizoma Coptidis powder respectively, effect is also bad." book on Chinese herbal medicine is stated ": bitter, cold, nontoxic." book on Chinese herbal medicine is just read ": enter liver, stomach blood system." China's book on Chinese herbal medicine ": return liver; Stomach warp.There is heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving effect.Treatment maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma tells nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.
Rhizoma Chuanxiong: ligustrazine energy coronary artery dilator, increases coronary artery blood flow, improves the blood oxygen supply of cardiac muscle, and reduces the oxygen consumption of cardiac muscle; The expansible cerebrovascular of ligustrazine, reduces vascular resistance, significantly increases brain and LBF amount, improves microcirculation; Can surface activity of blood platelet be reduced, suppress platelet aggregation, the formation of pre-preventing thrombosis; The neutral compound low dose of contained ferulic acid promotes, heavy dose of suppression uterine smooth muscle; Water decoction has sedation to animal central nervous systems, and has obvious and lasting hypotensive effect; The absorption of fracture local hematoma can be accelerated, promote callus formation; There is the effect of vitamin antagonist E shortage; Multiple bacillus can be suppressed; There are antihistaminic and choleretic effect.
Meropodium pearl: expelling wind and activating blood circulation, eliminating stasis to stop pain, antiinflammatory.Cure mainly rheumatic ostalgia, traumatic injury, nephroptosis, nephritis etc.
Parthenocissus: sweet, puckery, temperature.Function cures mainly: dispelling wind and removing obstruction in the collateral, promoting blood circulation and detoxication.For rheumatic arthritis; Traumatic injury is controlled in external, carbuncle furuncle and phyma poison.
Pericarpium Citri junoris: warm in nature, sweet-bitter flavor is nontoxic.Enter spleen, lung two warp.Function cures mainly: regulate the flow of vital energy, and reduces phlegm, spleen invigorating, intestinal stasis relieving.Cure cold cough, inappetence, chest and abdomen swelling and pain, and borborygmus are just rushed down, acute mastitis.
Bodhi is fragrant: pungent, sweet, flat.Function cures mainly: enriching yin and nourishing kidney, suppressing the hyperactive liver improving eyesight, reducing swelling and alleviating pain.Cure cold, dizziness headache, hypertension, anemia, chronic enterogastritis, menoxenia, mastitis, the diseases such as sore.
Radix Glycyrrhizae: property is put down, and sweet in the mouth, returns 12 warps.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic so that the pharmacological action such as anticancer, Radix Glycyrrhizae has blood fat reducing, antioxidative effect.
Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, micro-hardship, slightly warm in nature.Return spleen, kidney, heart channel.Modern medicine research proves that the action character of Radix Et Caulis Acanthopanacis Senticosi is substantially identical with Radix Ginseng, has and regulates body disorderly, make it to be tending towards normal function.Have good antifatigue effect, comparatively Radix Ginseng is remarkable, and significantly can improve hypoxia-bearing capability.The function such as invigorating middle warmer, benefit essence, strong will, wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt, stomach invigorating diuresis.Clothes of a specified duration " are made light of one's life by commiting suicide and are endured hardships ".Radix Et Caulis Acanthopanacis Senticosi contains noticeable composition---and eleutheroside, it can stimulate mind & body vigor.Numerous scientific publications about Radix Et Caulis Acanthopanacis Senticosi demonstrates its antifatigue effect, strengthens endurance and ability, increases alert and resourceful and learning capacity.Numerous usage obtains confirmation all in human experimentation.Radix Et Caulis Acanthopanacis Senticosi is rehabilitation after being ill, bears too much pressure or anxiety, works excessive, chronic disease cause weakly crowd and those need to reach very welcome self-medication medicine in the people on physiology and psychological performance peak.It has support immune system to have the report of considerable quantity to point out equally at present, recovers improper hypotension, improves blood circulation, makes disorderly glycolipid metabolism normalization, liver, testis, anabolic effect of bone density and other vitals.Radix Et Caulis Acanthopanacis Senticosi extract display can irritation cell immunity.Research finds that it can stimulate T-cell to produce, particularly assistant's cell.Therefore Radix Et Caulis Acanthopanacis Senticosi is used to panimmunity relevant disease.Radix Et Caulis Acanthopanacis Senticosi polysaccharide also has strong inhibitory action to the in-vitro multiplication of mice S180, K562 cell, and Radix Et Caulis Acanthopanacis Senticosi extract is containing multiple glycoside and Radix Et Caulis Acanthopanacis Senticosi polysaccharide, have improve immunity of organisms, leukocyte increasing, raising body to anoxia, radiation, stress, the adaptive capacity of the non-specific injury such as tired, poisoning.There is obvious inhibitory action to tumor, also can promote that marrow hemopoietic stem cells makes leukocyte increase to grain-differentiate monocytes simultaneously.
Caulis Akebiae: bitter, be slightly cold.Enter heart channel, small intestine meridian, urinary bladder channel.There is the effect of clearing away heart-fire, diuresis, stimulating milk secretion of stimulating the menstrual flow.For irritable feverish sensation in the chest, sore throat pharyngalgia, dark coloured urine, five types of stranguria, edema, whole body spasm and pain, amenorrhea breast is few.The puckery pain of pyretic stranguria, edema.This product energy inducing diuresis to remove edema, lower dampness removing heat, makes that damp and hot heresy is descending discharges from urine.Treatment damp-heat in the urinary bladder, oliguria with reddish urine, drenches the puckery pain of drop, the normal and adapted such as Semen Plantaginis, Talcum; For edema, be then equipped with Polyporus, the equivalent use of Cortex Mori.Aphtha of the mouth and tongue, vexed dark coloured urine.The fire of this product energy supernatant heart channel, under let out the heat of small intestinal.Often control flaming up of heart-fire, aphtha of the mouth and tongue, or intestinal and the diseases such as the vexed dark coloured urine that causes under heart-fire moving downward, the adapteds such as many and Radix Rehmanniae, Radix Glycyrrhizae, Folium Bambusae.Amenorrhea breast is few.These product stimulate the menstrual flow stimulating milk secretion.With controlling blood stasis amenorrhea, join Flos Carthami, Semen Persicae, the equivalent use of Radix Salviae Miltiorrhizae; If deficient or obstructed with controlling milk, can being equal to Semen Vaccariae, Squama Manis and using; These product can also sharp blood vessels, get round by bribery, join Ramulus Mori, Semen Coicis is equal to use, treat damp and hot arthralgia pain.
Rhizoma Cyperi: pungent micro-hardship is sweet, flat, enter liver, tri-jiao channel.Distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.
Colla Corii Asini: sweet is flat.Return lung, liver, kidney channel.Function cures mainly: YIN nourishing of enriching blood, and moisturizes, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
Radix et Caulis Opuntiae Dillenii: bitter, cool.Function cures mainly: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, benefiting stomach and stopping pain, antitussive.For taste-blindness rate, acute dysentery, cough; Mumps is controlled in external, mastitis, carbuncle furuncle and phyma poison, venom, burn and scald.
Lagerstroemia indica L.: micro-hardship, puckery, flat.Function cures mainly: invigorate blood circulation, hemostasis, removing toxic substances, detumescence.For various hemorrhage, fracture, mastitis, eczema, hepatitis, cirrhotic ascites.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, for diseases such as distension and fullness of the chest and abdomen.The pungent loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, is longer than and regulates the flow of vital energy, spleen lung can be entered, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gather around stagnant, chest and diaphragm feeling of fullness and the disease such as stagnation of QI in spleen and stomach, distension and fullness in the abdomen for lung qi, for retention of dampness in middle-JIAO, gastral cavity abdomen painful abdominal mass is swollen, have loose bowels in loose stool, and the disease such as abundant expectoration cough.Pericarpium Citri tangerinae dispelling the damp pathogen with bitter and warm drugs and can spleen invigorating circulation of qi promoting, therefore be usually used in the diseases such as retention of dampness in middle-JIAO, gastral cavity abdominal distention are vexed, loose stool greasy fur, can compatibility Rhizoma Atractylodis, Cortex Magnoliae Officinalis is with using.Be good at drying dampness to eliminate phlegm again, be control the conventional key medicine that damp-phlegm stops up lung, abundant expectoration cough, reduce for insufficiency of the spleen diet, dyspepsia, and the disease such as nausea and vomiting.This product dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and stomach, diet minimizings, dyspepsia, loose stool and diarrhea, often and the fit applications such as Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria.Because it can spleen invigorating, can regulate the flow of vital energy again, therefore the assistant being often used as Qi-tonifying drug makes, and can make tonify without causing stagnation, prevent heap soil or fertilizer over and around the roots from holding back and do swollen effect, in addition, Pericarpium Citri tangerinae again can with in, stomach-QI being unable to descend normally, nausea and vomiting can be controlled.
Semen Euryales: sweet in the mouth, puckery, property is put down.Cure mainly rheumatic arthritis, back gonalgia.Invigorating the spleen and replenishing QI, strong will of refreshing oneself, makes people's normal hearing and eyesight.It is not hungry that clothes of a specified duration make people make light of one's life by commiting suicide.Can also whet the appetite and help gas and the kidney invigorating, control frequency of micturition, seminal emission, purulent leukorrhea.Make powder to eat, beneficial people.But children's unsuitable polyphagia, not strengthening the spleen stomach, be difficult to digestion.
Endothelium Corneum Gigeriae Galli: sweet, cold, return spleen, stomach, small intestinal, urinary bladder channel, for promoting digestion and invigorating the stomach, arresting seminal emission.Endothelium Corneum Gigeriae Galli is containing gastric hormone, keratin, aminoacid and micro-pepsin, amylase etc.After oral Endothelium Corneum Gigeriae Galli powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and stomach motion is strengthened, emptying quickening.Its acid extraction liquid or decoct can accelerate to get rid of radiostrontium from urine.
Massa Medicata Fermentata: record according to " the southern regions of the Yunnan Province book on Chinese herbal medicine ", Massa Medicata Fermentata can " be held up taste to enter diet, disappear and stop the food of gastric every place ".Massa Medicata Fermentata is containing volume yeast, and vitamin B group, also containing multiple vitamin B group in cerevisin, therefore Massa Medicata Fermentata has the effect of vitamin B group sample.As appetite stimulator, maintain normal stool function etc.
Fructus Crataegi: section is dried, put in pot large stir-fry of useing force and be degree to outer wrinkly face brown, inner yellowish-brown, spray clear water, taking-up is dried, and is Fructus Crataegi (parched to brown).There is appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, circulation of qi promoting of reducing phlegm effect, meridian distribution of property and flavor, sour, sweet, slightly warm in nature.Main component is containing chlorogenic acid, caffeic acid, Crataegolic acid, neat chrysanthemum fruit acid, Quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin etc.Oral Fructus Crataegi can increase digestive enzyme, promotes decomposition and the digestion of fat, to because of eat meat or greasy too much caused by distension and fullness in the abdomen, belch, anorexia, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines test shows, Fructus Crataegi has slow and lasting effect reduced blood pressure, and also can reduce cholesterol and triglyceride, atherosclerosis, but also can diastole coronary artery, increases myocardial contraction, to arrhythmia.Therefore, be conducive to preventing and treating hypertension, hyperlipidemia, arteriosclerosis and coronary heart disease.
Medicine of the present invention also comprises: Formica fusca, Radix Bupleuri, Ganoderma and Radix Rhodiolae.
Formica fusca: salty in the mouth; Acid; Property is put down.Return liver; Kidney channel.Function cures mainly: the kidney invigorating and essence nourishing; Dredge the meridian passage; Removing toxic substances and promoting subsidence of swelling.Main dizzy tinnitus of suffering from a deficiency of the kidney; Insomnia and dreamful sleep; Impotence and seminal emission; Rheumatic arthralgia; Apoplectic hemiplegia 6; Numb hand and foot; Lupus erythematosus; Scleroderma; Dermatomyositis; Carbuncle furuncle; Venom.
Radix Bupleuri: clearind deficient heat Chinese medicine, comes off for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus, menoxenia.Radix Bupleuri begins to be loaded in Shennong's Herbal, is classified as top grade.Promote immunity function, effective ingredient: Bupleurum chinense polysaccharide.Effect: phagocytic function strengthens, Natural killer activity strengthens, and improves special viral antibody titre, improves lymphocyte and turns core rate, improve skin delayed hypersensitivity reaction.Anti-liver injury, injection of Radix Bupleuri (concentration 1: a 1) 1 ml/ subcutaneous injection significantly can reduce the rat blood serum GPT that carbon tetrachloride causes for continuous 5 days and raise, hepatocellular degeneration and necrosis also obviously alleviate, and in hepatocyte, glycogen and rna content are also close to normal.
Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, has phlegm-dispelling functions to respiratory system, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.
Radix Rhodiolae: sweet, puckery, cold.Function cures mainly: clearing away lung-heat to relieve cough, hemostasis, leukorrhagia stopping.For cough due to lung-heat, spitting of blood, leucorrhea; Traumatic injury is controlled in external, burn and scald.QI invigorating lung heat clearing; Fructus Alpiniae Oxyphyllae is nourished heart; Hemostasis with astringents; Dissipating blood stasis for subsidence of swelling.Main deficiency of vital energy and physically weak; Fear of cold after being ill; Shortness of breath and fatigue; Cough due to lung-heat; Spitting of blood; Leucorrhea is suffered from diarrhoea; Traumatic injury; Burn and scald; Neurosis; Altitude sickness.
Embodiment 1 powder 1
The embodiment of the present invention 1 provides a kind of medicine being used for the treatment of mammitis of cow, medicine is made up of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portion, Radix Codonopsis 15 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portion, Radix Angelicae Sinensis 15 weight portion, Herba Lactucae formosanae 20 weight portion, Rhizoma Et Radix Notopterygii 17 weight portion, Radix Isatidis 13 weight portion, Rhizoma Chuanxiong 17 weight portion, meropodium pearl 13 weight portion, parthenocissus 13 weight portion, Pericarpium Citri junoris 15 weight portion, the fragrant 17 amount parts of bodhi, Radix Glycyrrhizae 16 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Caulis Akebiae 12 weight portion, Rhizoma Cyperi 13 weight portion, Colla Corii Asini 12 weight portion, Radix et Caulis Opuntiae Dillenii 13 weight portion, Lagerstroemia indica L. 15 weight portion, Pericarpium Citri Reticulatae 14 weight portion, Semen Euryales 13 weight portion, Endothelium Corneum Gigeriae Galli 13 weight portion, Massa Medicata Fermentata 18 weight portion and Fructus Crataegi 13 weight portion.
The embodiment of the present invention additionally provides a kind of preparation method being used for the treatment of the medicine of mammitis of cow, and medicine is powder, and preparation method comprises the following steps:
The first step, is mixed in proportion all raw medicinal materials, is ground into 100 object powder, adds the water relative to mixture quality 5 times, at the temperature of 90 DEG C, decocts 30 minutes, and decoction liquor is filtered, and obtains the first filtrate and filtering residue;
Second step, adds the water relative to first step mixture quality 3 times by the filtering residue that the first step obtains, at the temperature of 90 DEG C, decocts 1 hour, and decoction liquor is filtered, and obtains the second filtrate;
3rd step, the first filtrate and the second filtrate are merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that inlet temperature is at 190 DEG C, leaving air temp 80 DEG C, is ground into 200 orders subsequently, obtains drug powder.
Embodiment 2 powder 2
Embodiments provide a kind of medicine being used for the treatment of mammitis of cow, medicine is made up of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portion, Radix Codonopsis 15 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portion, Radix Angelicae Sinensis 15 weight portion, Herba Lactucae formosanae 20 weight portion, Rhizoma Et Radix Notopterygii 17 weight portion, Radix Isatidis 13 weight portion, Rhizoma Chuanxiong 17 weight portion, meropodium pearl 13 weight portion, parthenocissus 13 weight portion, Pericarpium Citri junoris 15 weight portion, the fragrant 17 amount parts of bodhi, Radix Glycyrrhizae 16 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Caulis Akebiae 12 weight portion, Rhizoma Cyperi 13 weight portion, Colla Corii Asini 12 weight portion, Radix et Caulis Opuntiae Dillenii 13 weight portion, Lagerstroemia indica L. 15 weight portion, Pericarpium Citri Reticulatae 14 weight portion, Semen Euryales 13 weight portion, Endothelium Corneum Gigeriae Galli 13 weight portion, Massa Medicata Fermentata 18 weight portion, Fructus Crataegi 13 weight portion, Formica fusca 13 weight portion, Radix Bupleuri 17 weight portion, Ganoderma 12 weight portion and Radix Rhodiolae 13 weight portion.
The embodiment of the present invention additionally provides a kind of preparation method being used for the treatment of the medicine of mammitis of cow, and medicine is powder, and preparation method comprises the following steps:
The first step, is mixed in proportion all raw medicinal materials, is ground into 150 object powder, adds the water relative to mixture quality 4 times, at the temperature of 95 DEG C, decocts 45 minutes, and decoction liquor is filtered, and obtains the first filtrate and filtering residue;
Second step, adds the water relative to first step mixture quality 2 times by the filtering residue that the first step obtains, at the temperature of 95 DEG C, decocts 45 minutes, and decoction liquor is filtered, and obtains the second filtrate;
3rd step, the first filtrate and the second filtrate are merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that inlet temperature is at 180 DEG C, leaving air temp 70 DEG C, is ground into 300 orders subsequently, obtains drug powder.
Embodiment 3 unguentum
Embodiments provide a kind of medicine being used for the treatment of mammitis of cow, medicine is made up of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portion, Radix Codonopsis 15 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portion, Radix Angelicae Sinensis 15 weight portion, Herba Lactucae formosanae 20 weight portion, Rhizoma Et Radix Notopterygii 17 weight portion, Radix Isatidis 13 weight portion, Rhizoma Chuanxiong 17 weight portion, meropodium pearl 13 weight portion, parthenocissus 13 weight portion, Pericarpium Citri junoris 15 weight portion, the fragrant 17 amount parts of bodhi, Radix Glycyrrhizae 16 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Caulis Akebiae 12 weight portion, Rhizoma Cyperi 13 weight portion, Colla Corii Asini 12 weight portion, Radix et Caulis Opuntiae Dillenii 13 weight portion, Lagerstroemia indica L. 15 weight portion, Pericarpium Citri Reticulatae 14 weight portion, Semen Euryales 13 weight portion, Endothelium Corneum Gigeriae Galli 13 weight portion, Massa Medicata Fermentata 18 weight portion, Fructus Crataegi 13 weight portion, Formica fusca 13 weight portion, Radix Bupleuri 17 weight portion, Ganoderma 12 weight portion and Radix Rhodiolae 13 weight portion.
The embodiment of the present invention additionally provides a kind of preparation method being used for the treatment of the medicine of mammitis of cow, and medicine is unguentum, and preparation method comprises the following steps:
Take all raw medicinal materials by weight and soak 1.5 hours, be then placed in multi-function extractor, first time decocts 7 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 7 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.05MPa, temperature remains on 70 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 65 DEG C, cooling; The Margarita powder getting extractum weight 10% adds in extractum, stirs, tinning after ultraviolet radiation sterilizing.
Toxicity test
1, cumulative toxicity test report
Select 20 healthy mices, female, each 10 of hero, with the powder 1 of the embodiment of the present invention 1 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.With the powder 2 of embodiment 2 for object, carry out toxicity test according to the method described above, result is as identical in embodiment 1.
2, acute toxicity test
Application NIH mice 40, SPF level, male and female half and half, body weight 16 ~ 20g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The powder 1 prepared by embodiments of the invention 1 is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.The powder 1LD50>32.9 crude drug/kg of the Mouse oral gavage embodiment of the present invention 1, every day, maximum dosage-feeding was 65.8g crude drug/kg/ day.The clinical application amount of the powder 1 of the embodiment of the present invention 1 be 3g crude drug/day/head, pig weight is in 6kg, and average dosage is 0.5g crude drug/kg/ day.By weighing machine: the dosis tolerata of the powder 1 of mice (average weight is in 20g) the oral administration gavage embodiment of the present invention 1 is 131 times of quantity.Therefore the acute toxicity of the powder 1 of the embodiment of the present invention 1 is low, clinical drug safety.With the powder 2 of embodiment 2 for object, carry out toxicity test according to the method described above, result is as identical in embodiment 1.
3, external acute skin irritation test
These product are according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, the unguentum getting the 0.5g embodiment of the present invention 3 directly to spread upon on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.
4, external acute dermal toxicity test
These product are according to Ministry of Public Health " cosmetics health specification " (2002) Part II " acute dermal toxicity test " test method(s) of once limiting the quantity, SD rat 20, male and female half and half, body weight 90g ~ 180g, by the unguentum of the embodiment of the present invention 3, one time percutaneous smears 5000mg/kg body weight dose, observe 15 days, do not find obvious poisoning symptom, without dead, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.
Clinical trial
(1) laboratory animal
Laboratory animal 160 of providing for certain cattle farm suffer from the milch cow of mastitis after diagnosing.Tested on August 22,7 days to 2012 August in 2012, duration of test carries out daily feeding and management by cattle farm Routine Management way.
(2) test method
160 ill milch cows are divided into four experimental grouies at random, often organize 40, four experimental grouies use the medicine (embodiment group 2) of the medicine of the embodiment of the present invention 1 (embodiment group 1), embodiment 2, the medicine of embodiment 2 and the medicine of embodiment 3 jointly to use (embodiment group 3) and conventional medicament (matched group) to treat respectively.Powder 1 and powder 2 are mixed in water according to the part by weight of 1:5 and gavage by embodiment group 1 and embodiment group 2 respectively, twice daily, use 8-15 days continuously; In embodiment group 3, unguentum coordinates the powder 2 of embodiment 2 to use, and every day smeared twice by unguentum, uses 8-15 days continuously.
(3) criterion of therapeutical effect
Clinical trial of the present invention adopts California mastitis detection method (CMT) determination methods to provide curative effect determinate standard, and as shown in table 1, wherein effective percentage is the summation of " recovery from illness " and " improvement "; California mastitis detection method (CMT) determination methods and standard as shown in table 2.
Table 1 clinical trial curative effect determinate standard of the present invention
Table 2 California mastitis detection method (CMT) determination methods and standard
(4) therapeutic effect
Result is as shown in table 1, from therapeutic effect, adopts medicine of the present invention to be more than 90% to the treated effect of mammitis of cow.
From the data of table 1, compared with matched group, use the Drug therapy mammitis of cow of the embodiment of the present invention 1 and embodiment 2 to have evident in efficacy, that cure rate is high advantage, both oral medicine of the present invention and unguentum are especially obvious with the use of effect; Find in long-term observation subsequently, embodiment group 1, embodiment group 2 and embodiment group 3 recovery from illness milch cow again sickness rate be starkly lower than the milch cow of matched group.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. be used for the treatment of the medicine of mammitis of cow, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Herba Lactucae formosanae 15-25 weight portion, Rhizoma Et Radix Notopterygii 10-25 weight portion, Radix Isatidis 10-16 weight portion, Rhizoma Chuanxiong 13-20 weight portion, meropodium pearl 10-15 weight portion, parthenocissus 10-15 weight portion, Pericarpium Citri junoris 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Caulis Akebiae 10-15 weight portion, Rhizoma Cyperi 10-15 weight portion, Colla Corii Asini 10-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Lagerstroemia indica L. 10-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Semen Euryales 10-15 weight portion, Endothelium Corneum Gigeriae Galli 10-15 weight portion, Massa Medicata Fermentata 15-20 weight portion and Fructus Crataegi 10-15 weight portion.
2. the medicine being used for the treatment of mammitis of cow according to claim 1, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, Herba Lactucae formosanae 18-22 weight portion, Rhizoma Et Radix Notopterygii 15-20 weight portion, Radix Isatidis 12-14 weight portion, Rhizoma Chuanxiong 15-18 weight portion, meropodium pearl 12-14 weight portion, parthenocissus 12-14 weight portion, Pericarpium Citri junoris 13-18 weight portion, the fragrant 16-18 of bodhi measures part, Radix Glycyrrhizae 15-18 weight portion, Radix Et Caulis Acanthopanacis Senticosi 13-18 weight portion, Caulis Akebiae 11-14 weight portion, Rhizoma Cyperi 12-14 weight portion, Colla Corii Asini 11-14 weight portion, Radix et Caulis Opuntiae Dillenii 11-14 weight portion, Lagerstroemia indica L. 12-18 weight portion, Pericarpium Citri Reticulatae 12-17 weight portion, Semen Euryales 11-14 weight portion, Endothelium Corneum Gigeriae Galli 11-14 weight portion, Massa Medicata Fermentata 17-19 weight portion and Fructus Crataegi 12-14 weight portion.
3. the medicine being used for the treatment of mammitis of cow according to claim 1, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portion, Radix Codonopsis 15 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portion, Radix Angelicae Sinensis 15 weight portion, Herba Lactucae formosanae 20 weight portion, Rhizoma Et Radix Notopterygii 17 weight portion, Radix Isatidis 13 weight portion, Rhizoma Chuanxiong 17 weight portion, meropodium pearl 13 weight portion, parthenocissus 13 weight portion, Pericarpium Citri junoris 15 weight portion, the fragrant 17 amount parts of bodhi, Radix Glycyrrhizae 16 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Caulis Akebiae 12 weight portion, Rhizoma Cyperi 13 weight portion, Colla Corii Asini 12 weight portion, Radix et Caulis Opuntiae Dillenii 13 weight portion, Lagerstroemia indica L. 15 weight portion, Pericarpium Citri Reticulatae 14 weight portion, Semen Euryales 13 weight portion, Endothelium Corneum Gigeriae Galli 13 weight portion, Massa Medicata Fermentata 18 weight portion and Fructus Crataegi 13 weight portion.
4. be used for the treatment of the medicine of mammitis of cow, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Herba Lactucae formosanae 15-25 weight portion, Rhizoma Et Radix Notopterygii 10-25 weight portion, Radix Isatidis 10-16 weight portion, Rhizoma Chuanxiong 13-20 weight portion, meropodium pearl 10-15 weight portion, parthenocissus 10-15 weight portion, Pericarpium Citri junoris 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Caulis Akebiae 10-15 weight portion, Rhizoma Cyperi 10-15 weight portion, Colla Corii Asini 10-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Lagerstroemia indica L. 10-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Semen Euryales 10-15 weight portion, Endothelium Corneum Gigeriae Galli 10-15 weight portion, Massa Medicata Fermentata 15-20 weight portion, Fructus Crataegi 10-15 weight portion, Formica fusca 10-16 weight portion, Radix Bupleuri 15-20 weight portion, Ganoderma 10-15 weight portion and Radix Rhodiolae 10-15 weight portion.
5. the medicine being used for the treatment of mammitis of cow according to claim 4, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, Herba Lactucae formosanae 18-22 weight portion, Rhizoma Et Radix Notopterygii 15-20 weight portion, Radix Isatidis 12-14 weight portion, Rhizoma Chuanxiong 15-18 weight portion, meropodium pearl 12-14 weight portion, parthenocissus 12-14 weight portion, Pericarpium Citri junoris 13-18 weight portion, the fragrant 16-18 of bodhi measures part, Radix Glycyrrhizae 15-18 weight portion, Radix Et Caulis Acanthopanacis Senticosi 13-18 weight portion, Caulis Akebiae 11-14 weight portion, Rhizoma Cyperi 12-14 weight portion, Colla Corii Asini 11-14 weight portion, Radix et Caulis Opuntiae Dillenii 11-14 weight portion, Lagerstroemia indica L. 12-18 weight portion, Pericarpium Citri Reticulatae 12-17 weight portion, Semen Euryales 11-14 weight portion, Endothelium Corneum Gigeriae Galli 11-14 weight portion, Massa Medicata Fermentata 17-19 weight portion, Fructus Crataegi 12-14 weight portion, Formica fusca 12-14 weight portion, Radix Bupleuri 16-19 weight portion, Ganoderma 11-13 weight portion and Radix Rhodiolae 11-14 weight portion.
6. the medicine being used for the treatment of mammitis of cow according to claim 4, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portion, Radix Codonopsis 15 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portion, Radix Angelicae Sinensis 15 weight portion, Herba Lactucae formosanae 20 weight portion, Rhizoma Et Radix Notopterygii 17 weight portion, Radix Isatidis 13 weight portion, Rhizoma Chuanxiong 17 weight portion, meropodium pearl 13 weight portion, parthenocissus 13 weight portion, Pericarpium Citri junoris 15 weight portion, the fragrant 17 amount parts of bodhi, Radix Glycyrrhizae 16 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Caulis Akebiae 12 weight portion, Rhizoma Cyperi 13 weight portion, Colla Corii Asini 12 weight portion, Radix et Caulis Opuntiae Dillenii 13 weight portion, Lagerstroemia indica L. 15 weight portion, Pericarpium Citri Reticulatae 14 weight portion, Semen Euryales 13 weight portion, Endothelium Corneum Gigeriae Galli 13 weight portion, Massa Medicata Fermentata 18 weight portion, Fructus Crataegi 13 weight portion, Formica fusca 13 weight portion, Radix Bupleuri 17 weight portion, Ganoderma 12 weight portion and Radix Rhodiolae 13 weight portion.
7. the preparation method being used for the treatment of the medicine of mammitis of cow as described in any one of claim 1-6, is characterized in that, described preparation method comprises the following steps:
The first step, is mixed in proportion all raw medicinal materials, is ground into 100 order ~ 200 object powder, add the water relative to mixture quality 3 ~ 5 times, at the temperature of 90 DEG C ~ 100 DEG C, decoct 30 minutes ~ 1 hour, decoction liquor is filtered, and obtains the first filtrate and filtering residue;
Second step, adds the water relative to first step mixture quality 1 ~ 3 times by the filtering residue that the first step obtains, at the temperature of 90 DEG C ~ 100 DEG C, decocts 30 minutes ~ 1 hour, and decoction liquor is filtered, and obtains the second filtrate;
3rd step, the first filtrate and the second filtrate are merged, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer dry, ensure that inlet temperature is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, is ground into 200 order ~ 400 orders subsequently, obtains drug powder.
8. the preparation method being used for the treatment of the medicine of mammitis of cow as described in any one of claim 1-6, is characterized in that, described medicine is emulsifiable paste, and described preparation method comprises the following steps:
Take all raw medicinal materials by weight and soak 1-2 hour, be then placed in multi-function extractor, first time decocts 5-10 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 5-10 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C, cooling; The Margarita powder getting extractum weight 10% adds in extractum, stirs, tinning after ultraviolet radiation sterilizing.
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| CN201310722875.8A CN103656048B (en) | 2013-12-25 | 2013-12-25 | Medicine being used for the treatment of mammitis of cow and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104304809B (en) * | 2014-11-09 | 2016-08-17 | 蒋法成 | Milk cow in lactation period feed additive and application thereof |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104642816B (en) * | 2015-03-20 | 2017-03-22 | 广州市番禺区大川饲料有限公司 | Feed preventing egg drop syndrome of laying duck |
| CN106720982A (en) * | 2016-11-28 | 2017-05-31 | 全椒凤巢植保专业合作社 | A kind for the treatment of method of milk goat mastitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101181011B (en) * | 2007-11-23 | 2010-09-01 | 金陵科技学院 | Chinese herbal medicine feedstuff additive-summer quiet powder and preparation method as well as application thereof |
| CN101554400B (en) * | 2008-04-09 | 2011-09-21 | 北京大北农动物保健科技有限责任公司 | Medicine for preventing and curing agalactia, lactation lack and mastitis of livestock and preparation method thereof |
| CN102488814B (en) * | 2011-12-22 | 2013-12-04 | 中国农业科学院北京畜牧兽医研究所 | Chinese medicinal composition for treating bovine mastitis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104304809B (en) * | 2014-11-09 | 2016-08-17 | 蒋法成 | Milk cow in lactation period feed additive and application thereof |
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