CN103652501B - Feed for treating cow mastitis and preparation method thereof - Google Patents
Feed for treating cow mastitis and preparation method thereof Download PDFInfo
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- CN103652501B CN103652501B CN201310722973.1A CN201310722973A CN103652501B CN 103652501 B CN103652501 B CN 103652501B CN 201310722973 A CN201310722973 A CN 201310722973A CN 103652501 B CN103652501 B CN 103652501B
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Abstract
The invention discloses a feed for treating cow mastitis and a preparation method thereof. The feed comprises the following raw materials: barley, oat, soybean, peanut meal, dry alfalfa powder, shaddock peel, needle mushroom dreg, kelp powder and traditional Chinese medicine additives. The feed for treating the cow mastitis has the following benefits: the feed contains the traditional Chinese medicine additives, and uses heat clearing, poison removal, blood activation, blood stasis removal, painful menstruation relieving and collaterals activation as main treatment principles; the traditional Chinese medicine additives are matched and coacted with other raw materials of the feed, so that the immunity and disease resistance of cows can be improved, and the treatment of the mastitis has the advantages of good treating effect, difficult relapse, low toxic and side effects and no residue; the feed is fitted with external ointment to achieve better treating effect.
Description
Technical field
The present invention relates to field of feed, particularly a kind of feed being used for the treatment of mastitis for milk cows and preparation method thereof.
Background technology
Mastitis for milk cows is the inflammation of mammary glandular cell and mammary gland interstitial.Cause the pathogen of breast inflammation, about 85% is streptococcus, micrococcus scarlatinae etc., and 5% is staphylococcus.Other have tubercle bacillus, Brucella, corynebacterium pyogenes, Escherichia coli, mycoplasma and mould etc.The economic loss that mastitis for milk cows causes is very large, is first that the output of milk reduces, is secondly that disease breast can not be drunk, even gives people's communicate illness, work the mischief to people ' s health.If mammitis can not be treated in time, often make mastatrophy, milk can not be sold, and even completely loses galactogogue action.Therefore the work preventing and treating mammitis will be performed.
At present, many employing antibiotic therapy mastitis for milk cows, result for the treatment of is undesirable, and drug tolerant bacteria also by milk-born infection to people, antibiotic residual in milk cow in addition also can bring out human body generation hypersensitivity, and therefore, the non-antibiotic therapy of mastitis for milk cows causes the concern of people gradually.
Be conceived to entirety during the traditional traditional Chinese medicine application of China, emphasize to regulate allomeric function, improve the premunition of body self.Chinese medicine belongs to natural drug, has antibacterial, anti-inflammatory, not easily makes pathogenic bacteria produce the effect of drug resistance and Immune-enhancing effect, has the feature of safety, efficient, low toxicity, low-residual, can overcome a large amount of drawback using antibiotic to bring; Chinese herbal medicine has enhancing human body immune function, improves animal resisting stress, anti-disease ability, improves the multiple efficacies such as breeding performonce fo animals, and have no drug resistance, noresidue, toxic and side effect be little, demonstrates unique advantage in livestock and poultry cultivation.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of feed being used for the treatment of mastitis for milk cows and preparation method thereof, adopt have that curative effect is high, toxic and side effect is little containing the treatment of feed to mastitis for milk cows of Chinese medicine additive, noresidue, do not develop immunity to drugs, non-environmental-pollution the advantage of Abwehrkraft des Koepers and short treating period can be increased.
In order to realize foregoing invention object, the invention provides a kind of feed being used for the treatment of mastitis for milk cows, it is characterized in that, described feed comprises following raw material: barley, oat, soybean, peanut meal, clover dry powder, pomelo peel, needle mushroom dreg, Kelp Powder and Chinese medicine additive.
Described feed is made up of the raw material of following parts by weight: barley 50-70 weight portion, oat 40-60 weight portion, soybean 30-50 weight portion, peanut meal 20-30 weight portion, clover dry powder 20-30 weight portion, pomelo peel 10-15 weight portion, needle mushroom dreg 10-15 weight portion, Kelp Powder 10-15 weight portion and Chinese medicine additive 5-17 weight portion.
Described feed is made up of the raw material of following parts by weight: barley 55-65 weight portion, oat 45-55 weight portion, soybean 35-45 weight portion, peanut meal 23-25 weight portion, clover dry powder 22-25 weight portion, pomelo peel 10-15 weight portion, needle mushroom dreg 10-15 weight portion, Kelp Powder 10-15 weight portion and Chinese medicine additive 9-17 weight portion.
Described Chinese medicine additive comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, finelydivided phtheirospermum root, Radix Angelicae Sinensis, bitter leaves, notopterygium root, Radix Isatidis, Ligusticum wallichii, meropodium pearl, Boston ivy, orange peel, bodhi perfume, Radix Glycyrrhizae, wilsonii, akebi, rhizoma cyperi, donkey-hide gelatin, cactus, crape myrtle, dried orange peel, Gorgon fruit, the membrane of a chicken's gizzard, Divine Comedy and hawthorn.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, finelydivided phtheirospermum root 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, bitter leaves 15-25 weight portion, notopterygium root 10-25 weight portion, Radix Isatidis 10-16 weight portion, Ligusticum wallichii 13-20 weight portion, meropodium pearl 10-15 weight portion, Boston ivy 10-15 weight portion, orange peel 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, wilsonii 10-20 weight portion, akebi 10-15 weight portion, rhizoma cyperi 10-15 weight portion, donkey-hide gelatin 10-15 weight portion, cactus 10-15 weight portion, crape myrtle 10-20 weight portion, dried orange peel 10-20 weight portion, Gorgon fruit 10-15 weight portion, the membrane of a chicken's gizzard 10-15 weight portion, Divine Comedy 15-20 weight portion and hawthorn 10-15 weight portion.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, finelydivided phtheirospermum root 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, bitter leaves 18-22 weight portion, notopterygium root 15-20 weight portion, Radix Isatidis 12-14 weight portion, Ligusticum wallichii 15-18 weight portion, meropodium pearl 12-14 weight portion, Boston ivy 12-14 weight portion, orange peel 13-18 weight portion, the fragrant 16-18 of bodhi measures part, Radix Glycyrrhizae 15-18 weight portion, wilsonii 13-18 weight portion, akebi 11-14 weight portion, rhizoma cyperi 12-14 weight portion, donkey-hide gelatin 11-14 weight portion, cactus 11-14 weight portion, crape myrtle 12-18 weight portion, dried orange peel 12-17 weight portion, Gorgon fruit 11-14 weight portion, the membrane of a chicken's gizzard 11-14 weight portion, Divine Comedy 17-19 weight portion and hawthorn 12-14 weight portion.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portion, Radix Codonopsis 15 weight portion, finelydivided phtheirospermum root 13 weight portion, Radix Angelicae Sinensis 15 weight portion, bitter leaves 20 weight portion, notopterygium root 17 weight portion, Radix Isatidis 13 weight portion, Ligusticum wallichii 17 weight portion, meropodium pearl 13 weight portion, Boston ivy 13 weight portion, orange peel 15 weight portion, the fragrant 17 amount parts of bodhi, Radix Glycyrrhizae 16 weight portion, wilsonii 15 weight portion, akebi 12 weight portion, rhizoma cyperi 13 weight portion, donkey-hide gelatin 12 weight portion, cactus 13 weight portion, crape myrtle 15 weight portion, dried orange peel 14 weight portion, Gorgon fruit 13 weight portion, the membrane of a chicken's gizzard 13 weight portion, Divine Comedy 18 weight portion and hawthorn 13 weight portion.
Described Chinese medicine additive also comprises: ant, radix bupleuri, glossy ganoderma and rhodiola root.
Described feed is made up of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, finelydivided phtheirospermum root 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, bitter leaves 15-25 weight portion, notopterygium root 10-25 weight portion, Radix Isatidis 10-16 weight portion, Ligusticum wallichii 13-20 weight portion, meropodium pearl 10-15 weight portion, Boston ivy 10-15 weight portion, orange peel 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, wilsonii 10-20 weight portion, akebi 10-15 weight portion, rhizoma cyperi 10-15 weight portion, donkey-hide gelatin 10-15 weight portion, cactus 10-15 weight portion, crape myrtle 10-20 weight portion, dried orange peel 10-20 weight portion, Gorgon fruit 10-15 weight portion, the membrane of a chicken's gizzard 10-15 weight portion, Divine Comedy 15-20 weight portion, hawthorn 10-15 weight portion, ant 10-16 weight portion, radix bupleuri 15-20 weight portion, glossy ganoderma 10-15 weight portion and rhodiola root 10-15 weight portion.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, finelydivided phtheirospermum root 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, bitter leaves 18-22 weight portion, notopterygium root 15-20 weight portion, Radix Isatidis 12-14 weight portion, Ligusticum wallichii 15-18 weight portion, meropodium pearl 12-14 weight portion, Boston ivy 12-14 weight portion, orange peel 13-18 weight portion, the fragrant 16-18 of bodhi measures part, Radix Glycyrrhizae 15-18 weight portion, wilsonii 13-18 weight portion, akebi 11-14 weight portion, rhizoma cyperi 12-14 weight portion, donkey-hide gelatin 11-14 weight portion, cactus 11-14 weight portion, crape myrtle 12-18 weight portion, dried orange peel 12-17 weight portion, Gorgon fruit 11-14 weight portion, the membrane of a chicken's gizzard 11-14 weight portion, Divine Comedy 17-19 weight portion, hawthorn 12-14 weight portion, ant 12-14 weight portion, radix bupleuri 16-19 weight portion, glossy ganoderma 11-13 weight portion and rhodiola root 11-14 weight portion.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portion, Radix Codonopsis 15 weight portion, finelydivided phtheirospermum root 13 weight portion, Radix Angelicae Sinensis 15 weight portion, bitter leaves 20 weight portion, notopterygium root 17 weight portion, Radix Isatidis 13 weight portion, Ligusticum wallichii 17 weight portion, meropodium pearl 13 weight portion, Boston ivy 13 weight portion, orange peel 15 weight portion, the fragrant 17 amount parts of bodhi, Radix Glycyrrhizae 16 weight portion, wilsonii 15 weight portion, akebi 12 weight portion, rhizoma cyperi 13 weight portion, donkey-hide gelatin 12 weight portion, cactus 13 weight portion, crape myrtle 15 weight portion, dried orange peel 14 weight portion, Gorgon fruit 13 weight portion, the membrane of a chicken's gizzard 13 weight portion, Divine Comedy 18 weight portion, hawthorn 13 weight portion, ant 13 weight portion, radix bupleuri 17 weight portion, glossy ganoderma 12 weight portion and rhodiola root 13 weight portion.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, mixes in proportion by all raw medicinal materials, is ground into 100 order ~ 200 object powder, add the water relative to mixture quality 3 ~ 5 times, at the temperature of 90 DEG C ~ 100 DEG C, decoct 30 minutes ~ 1 hour, decoction liquor is filtered, and obtains the first filtered fluid and filter residue;
Second step, adds the water relative to first step mixture quality 1 ~ 3 times by the filter residue that the first step obtains, at the temperature of 90 DEG C ~ 100 DEG C, decocts 30 minutes ~ 1 hour, and decoction liquor is filtered, and obtains the second filtered fluid;
3rd step, the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, is ground into 200 order ~ 400 orders subsequently, obtains Chinese medicine additive powder.
In order to better realize foregoing invention object, the invention provides a kind of preparation method being used for the treatment of the feed of mastitis for milk cows, described preparation method comprises the following steps:
(1) destruction step: take corn, wheat, millet, oat, alfalfa meal and honey skin of beancurd by weight, drops into pulverizer and carries out Crushing of Ultrafine, crosses 2.0mm sieve after pulverizing;
(2) batching step: take salt, vitamin D and Chinese medicine additive according to parts by weight, pulverizes with step (1) fine powder obtained and mixes, and drop into mixer, mix, incorporation time is 30-60s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 85 DEG C, makes its gelatinization degree reach more than 90%.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: feed of the present invention contains Chinese medicine additive, with clearing heat and detoxicating, promoting blood circulation and removing blood stasis, dysmenorrhoea is active is primary treatment principle, cooperatively interact with other feedstuffs, acting in conjunction, immunity and the resistance against diseases of milk cow can not only be improved, to the treatment of mammitis, there is good effect, not easily recur, toxic and side effect is little, the advantage of noresidue; Wherein, feed formulation medicinal external emulsifiable paste of the present invention uses, and result for the treatment of is more excellent.
Detailed description of the invention
Mastitis for milk cows symptom is the inflammation of mammary parenchyma, interstitial.The cause of disease is many caused by mechanical irritation, pathogenic microorganism immersion and chemicals rationality are damaged.1. environmental management factor: environmental condition is as muddy in cowshed, ox bed and sports ground can't bear, and around ox body and breast, incrustation is too many, and sanitary condition is too poor, too high (more than 36 DEG C) of temperature or too low (less than-5 DEG C) etc.Milking conditions does not meet lactation physiological requirement, as too high in negative pressure of vacuum, too low, and unsuitable scouring breast and embarkation are milked.2. pathogenic infection: up to the present, people have isolated 150 kinds of pathogenic microorganisms from cow mammary gland tissue, and modal have 23 kinds, wherein 14 kinds, bacterium, mycoplasma 2 kinds, fungi and 7 kinds, virus.What wherein the incidence of disease was the highest is staphylococcus aureus, Escherichia coli, streptococcus, and mycoplasma, the fungus-caused mammitis incidence of disease rise year by year in recent years.3. ox oneself factor: be in lactation and contain phase or the too high milk cow of milk production, body energy is in negative balance resistance, aged ox, polyembryony time ox relative incidence rate are high.4. secondary factors: the author finds the babesiasis of milk cow in clinical treatment in recent years, also can become the paathogenic factor of mastitis for milk cows, and treatment is got up also very difficult.There is PNI also can cause mammitis occurs again.For this reason, first protopathy should be controlled after Secondary cases mammitis being made a definite diagnosis.
Mastitis for milk cows can be divided into serosity mammitis, cellulosic catarrh mammitis, suppurative mammitis, hemorrhagic mammitis, gangrenous mastitis and recessive mastitis.Clinic mastitis: be the inflammation of breast interstitial, essence or interstitial parenchymal tissue.It is characterized in that milk sex change, breast tissue presents swelling, warm and pain to some extent.Different with coincident with severity degree of condition according to course of disease length, can the most acute, acute, subacute and chronic mastitis be divided into.The most acute: suddenly, development rapidly, is multiplely born in 1 Ge Ru district in morbidity; Recessive mastitis: also known as Subclinical mammitis.For a kind of mammitis showed without clinical symptoms.It is characterized in that breast and milk without naked eyes as seen extremely, but milk changes on physicochemical property, bacteriology.Concrete manifestation pH value more than 7.0, in meta-alkalescence; Newborn block, floccule, fiber is had in breast; Sodium chloride content is more than 0.14%, and somatic number is at 500,000/more than mL, and bacterial population and electric conductivity value increase; Chronic cases: because breast tissue is progressive inflammation process, lactation acinus wrecks in a big way, and breast tissue generation fibrillatable, often causes mastatrophy and induration of breast.
Chinese veterinarian's traditional theory is thought, mammitis and acute mastitis, is phlegm, wet, gas, blood stasis knot is loose and be scorching.Because feeding and management is not good at, sleeping damp and hot ground, damp and hot poison gas steams for a long time, infringement breast; Or because of hyperpyrexia of stomach, stagnation of QI due to depression of the liver, newborn network loses smooth so that breast qi and blood stagnation, stasis and raw carbuncle swells; Or inhale breast because of calf, milk is stagnated, reasons such as breast turgor and cause this disease.Therefore, the present invention with clearing heat and detoxicating, dredging collateral is invigorated blood circulation, swelling and pain relieving, active logical breast be for principle of reatment, provide a kind of feed being used for the treatment of mastitis for milk cows containing Chinese medicine additive, Chinese medicine additive comprises: the Radix Astragali, Radix Codonopsis, finelydivided phtheirospermum root, Radix Angelicae Sinensis, bitter leaves, notopterygium root, Radix Isatidis, Ligusticum wallichii, meropodium pearl, Boston ivy, orange peel, bodhi perfume, Radix Glycyrrhizae, wilsonii, akebi, rhizoma cyperi, donkey-hide gelatin, cactus, crape myrtle, dried orange peel, Gorgon fruit, the membrane of a chicken's gizzard, Divine Comedy and hawthorn.
Wherein, the pharmacological property of each raw medicinal material is as follows:
The Radix Astragali: based on qi-restoratives, energy invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, expelling pus and promoting granulation.For insufficiency of vital energy and blood, sore caves in, purulence one-tenth is not burst or of a specified duration bursting does not hold back person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration, i.e. the abscess suppuration myogenic of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and can strengthen the immunologic function of body, therefore can also be used for the generation preventing some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five zang organs, controls arteries and veins string spontaneous perspiration, rush down yin fire, remove lung heat, lossless, sends out, has sweat then to stop." be the good medicine promoting resistance and defence disease.
Radix Codonopsis: property is put down, sweet, the micro-acid of taste.Return spleen, lung channel.Tonifying middle-Jiao and Qi, invigorating the spleen benefit lung.Weak for the spleen deficiency syndrome of the lung, palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst." book on Chinese herbal medicine justice " carries: Radix Codonopsis power energy tonifying spleen nourishing the stomach, and moistening lung is promoted the production of body fluid, and gas in tendon fortune, this is very mutually not far away with ginseng.Its outstanding valuable person, then invigorating the spleen fortune and not dry, grow stomach-Yin and not wetting, moistening lung and do not violate cold and cool, nourishes blood and partially do not grow greasy, inspiring clear sun, gas in vibration, and without just dry fraud.Radix Astragali tonifying Qi, can enriching spleen-QI be risen, can admittedly show by beneficial lung again.Radix Codonopsis tonifying Qi, can only invigorating the spleen tonifying Qi, and without the power of solid table, but Radix Codonopsis can also nourishing generate fluid, and the Radix Astragali is then without the effect of promoting the production of body fluid, and the Radix Astragali double energy Li Shui, Radix Codonopsis acts on without Li Shui.This two tastes medicine share can tonifying middle-Jiao and Qi, improves resistance.
Finelydivided phtheirospermum root: property is put down, taste is worked hard.Function cures mainly: mental-tranquilization, hemostasis.Control and have a weak heart, palpitaition, cough blood-stained sputum.Clearing heat and detoxicating, mental-tranquilization, pain relieving.For having a weak heart, palpitaition, cough, blood-stained sputum, abscess of throat, fracture; Snake, dog bite are controlled in external application.
Radix Angelicae Sinensis: taste is sweet and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting circulation of blood, and bowl spares has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, tonifying Qi production of sperm, five viscera settling, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain defaecation of dispelling, relieving rigidity of muscles and joints, controls contraction, paralysis, the card such as dry, puckery.Empty and the exterior syndrome being not relieved person of battalion, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, can fall apart greatly Biao Weire, and show not hold back person, helps with rheum officinale and so on, can admittedly show again.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Bitter leaves: bitter; Cold in nature, function cures mainly: clearing heat and detoxicating; Wines used as antirheumatic; Invigorate blood circulation.Main furunculosis carbuncle swells; Abscess of throat; Mange; Hemorrhoid; Snake bite; Arthralgia due to wind-dampness; Traumatic injury.
Notopterygium root: return bladder; Kidney channel.Nature and flavor: taste is pungent; Bitter; Warm in nature.Loose exterior cold; Wines used as antirheumatic; Profit joint; Pain relieving.Loose exterior cold, wines used as antirheumatic, sharp joint.Cure cold chill, has a headache lossless, wind-cold-dampness arthralgia, the strong muscular contracture of item, joint ache, geomantic omen edema, skin sore.For impotence and seminal emission, enuresis frequent micturition, waist knee crymodynia, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External application curing vitiligo, alopecia areata.Induce sweat loose cold, expelling wind and eliminating dampness, pain relieving.For catching cold, fever with aversion to cold, the cards such as headache bodily pain.This product has stronger expelling cold, eliminating and analgesic effect.Often be equal to use with windproof, the root of Dahurain angelica, the root of Chinese wild ginger, as Notoptreygium Decoction of Nine Ingredients.For podomere pain, aching pain in should and back caused by wind-cold damp pathogen invasion and attack, outstanding above hemialgia is more applicable.This product can be dispeled the wind and be won temperature, eliminating cold to stop pain.Often with windproof, same to use, as juanbi decoction." property of medicine opinion ": " control harmful wind, aphonia in silence, blood leprosy of itching, hands and feet caused by paralysis, the askew heresy of actinal surface, stupid numbness all over more." " Japan hanako materia medica ": " control a wind cutting and gas, muscles and bones fist contraction, four limbs are thin bad, and head revolves the red pain of eyes and mass located in the upper or lower abdomen aqueous vapor, general debility, deficient cold air, joint ache, tonneau the five internal organs." " pearl sac ": " Taiyang channel is had a headache, and removes all arthralgias, also can warm courage." " product remittance essence is wanted ": " and main all joints being painful all over, flesh table Bafeng thief heresy, except new and old rheumatism, row's slough subcutaneous ulcer sore." essentials of Matea Medica: " purging the liver of pathogenic fire gas, searches liver wind, controls evils of wind and weness blended to attack the body, and herbal classic (sun) is had a headache, and governor vessel is disease, back rigidity and fainting, and the soft convulsion of tonic convulsion, aphasia from apoplexy, head revolves hot eyes." " about can cure mirror ": " control heresy and close the loathing of cold, high fever is lossless.”
Radix Isatidis: resisting pathogenic microbes effect: Radix Isatidis has inhibitory action to various bacteria.Infusion has inhibitory action in various degree to hay bacillus, staphylococcus aureus, sarcine, Escherichia coli, typhoid bacillus, paratyphosum Bacterium, dysentery (will congratulate, Fu Shi) bacillus, bacillus enteritidis etc.; Acetone leachate also has similar effect, and to hemolytic streptococcus effectively (all using agar aperture flat band method).Similar to the bacteriostasis of A type meningococcus and garlic, honeysuckle.Infected by influenza PR8 strain and Jing Ke 68-1 strain have obvious inhibitory action.In vitro leptospiral effect killed by Radix Isatidis.To cardiovascular effect: these product can make the in vitro rabbit ear and rat lower limb perfusion flow increase, and improve Rabbit Mesentery microcirculation, reduce the blood pressure of Anaesthetic Rabbits, reduce capillary permeability, and make mouse cardiac muscle oxygen demand decline.Antiaggregating activity on platelet effect Radix Isatidis has remarkable inhibitory action to the Platelet Aggregation in Rabbits that ADP induces.From Radix Isatidis, get uridine, hypoxanthine, pyrimidine, salicylic acid etc. also all show certain inhibit activities to the Platelet Aggregation in Rabbits that ATP induces, when 0.21mg/kg concentration, its inhibiting rate is respectively 18.2%, 24.2%, 10.8% and 20%.Detoxication: dog Radix Isatidis, coptis powder and black false hellebore, with taking (each 2.0g/kg), can separate black false hellebore poison, reduces the death rate; If again with it after veratrum poisoning, then invalid; Alone Radix Isatidis powder or coptis powder respectively, effect is also bad." book on Chinese herbal medicine is stated ": bitter, cold, nontoxic." book on Chinese herbal medicine is just read ": enter liver, stomach blood system." China's book on Chinese herbal medicine ": return liver; Stomach warp.There is heat-clearing, removing toxic substances, cool blood, relieve sore throat effect.Treatment febrile virulent maculae; High heat headache; Major part pestilence; Tongue is secretly dark reddish purple, scarlet fever; Erysipelas; Mumps; Larynx numbness; Sore is swollen, carbuncle swells; Varicella; Measles; Hepatitis; Influenza, epidemic meningitis, encephalitis, pneumonia, coma tells nosebleed, and pharynx is swollen, pinkeye, sore rash; Japanese Type-B encephalitis, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.
Ligusticum wallichii: ligustrazine energy coronary artery dilator, increases coronary blood flow, improves the blood oxygen supply of cardiac muscle, and reduces the oxygen demand of cardiac muscle; The expansible cerebrovascular of ligustrazine, reduces vascular resistence, significantly increases brain and LBF amount, improves microcirculation; Can surface activity of blood platelet be reduced, suppress platelet aggregation, the formation of pre-preventing thrombosis; The neutral compound low dose of contained forulic acid promotes, heavy dose of suppression uterine smooth muscle; Water decoction has sedation to animal central nervous systems, and has obvious and lasting hypotensive effect; The absorption of fracture local hematoma can be accelerated, promote that poroma is formed; There is the effect of antivitamin E shortage; Multiple bacillus can be suppressed; There are antihistaminicum and choleretic effect.
Meropodium pearl: expelling wind and activating blood flow, blood stasis removing analgesic, anti-inflammatory.Cure mainly treating rheumatic ostealgia, traumatic injury, nephroptosis, ephritis etc.
Boston ivy: sweet, puckery, temperature.Function cures mainly: dispelling wind and removing obstruction in the meridians, promoting blood circulation and detoxication.For rheumatic arthritis; Traumatic injury is controlled in external application, carbuncle furuncle poison.
Orange peel: warm in nature, sweet-bitter flavor is nontoxic.Enter spleen, lung two warp.Function cures mainly: regulate the flow of vital energy, and reduces phlegm, invigorating the spleen, leads stagnant.Cure cold cough, and poor appetite, chest and abdomen swelling and pain, borborygmus are just rushed down, acute mastitis.
Bodhi is fragrant: pungent, sweet, flat.Function cures mainly: enriching yin and nourishing kidney, flat liver improving eyesight, swelling and pain relieving.Cure cold, dizziness headache, hypertension, anaemia, chronic enterogastritis, irregular menstruation, mastitis, the diseases such as sore.
Radix Glycyrrhizae: property is put down, and taste is sweet, returns 12 warps.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, the anxious pain of gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolysis so that the pharmacological action such as anticancer, Radix Glycyrrhizae has reducing blood lipid, oxidation resistant effect.
Wilsonii: pungent, the micro-hardship of taste, slightly warm in nature.Return spleen, kidney, the heart channel of Hang-Shaoyin.Modern medicine research proves that the action character of wilsonii is substantially identical with ginseng, has and regulates body disorderly, make it to be tending towards normal function.Have good antifatigue effect, comparatively ginseng is remarkable, and significantly can improve hypoxia-bearing capability.Bowl spares, benefit essence, strong will, wines used as antirheumatic, strengthen the bone, blood circulation and promoting silt, the function such as stomach invigorating diuresis.Clothes of a specified duration " are made light of one's life by commiting suicide and are endured hardships ".Wilsonii contains noticeable composition---and eleutheroside, it can stimulate mind & body vigor.Numerous scientific publications about wilsonii demonstrates its antifatigue effect, strengthens endurance and ability, increases alert and resourceful and learning ability.Numerous usage obtains confirmation all in human experimentation.Wilsonii is rehabilitation after being ill, bears too much pressure or anxiety, works excessive, chronic disease cause weakly crowd and those need to reach very welcome self-medication medicine in the people on physiology and psychological performance peak.It has support immune system to have the report of considerable quantity to point out equally at present, recovers improper low blood pressure, improves the circulatory system, makes disorderly glycolipid metabolism normalization, liver, testis, anabolic effect of bone density and other vitals.Siberian Ginseng P.E display can irritation cell immunity.Research finds that it can stimulate T-cell to produce, particularly assistant's cell.Therefore wilsonii is used to panimmunity relevant disease.Radix Et Caulis Acanthopanacis Senticosi polysaccharide also has strong inhibitory action to the in-vitro multiplication of mouse S180, K562 cell, and siberian Ginseng P.E is containing multiple glucoside and Radix Et Caulis Acanthopanacis Senticosi polysaccharide, have improve immunity of organisms, increasing leukocyte, raising body to anoxic, radiation, stress, the adaptive capacity of the non-specific injury such as tired, poisoning.There is obvious inhibitory action to tumour, also can promote that marrow hemopoietic stem cells makes leucocyte increase to grain-differentiate monocytes simultaneously.
Akebi: bitter, be slightly cold.Enter the heart channel of Hang-Shaoyin, small intestinl channel, urinary bladder channel.There is the effect of clearing away the heart-fire, diuresis, lactogenesis of stimulating the menstrual flow.For irritable feverish sensation in chest, larynx numbness pharyngalgia, urinates red, and five drench, oedema, whole body contraction pain, few through closing breast.Heat drenches puckery pain, oedema.This product energy inducing diuresis for removing edema, lower dampness removing heat, makes that damp and hot heresy is descending discharges from urine.Treatment bladder damp-heat, scanty drak urine, drenches the puckery pain of drop, the normal and adapted such as plantain seed, talcum; For oedema, be then equipped with umbellate pore furgus, the equivalent use of the root bark of white mulberry.Aphthae, vexed urine is red.The fire of this product energy supernatant the heart channel of Hang-Shaoyin, under let out the heat of small intestine.Often control flaring up of heart fire, aphthae, or intestines and the disease such as the vexed urine that causes is red under heart-fire moving downward, the adapteds such as many and radix rehmanniae recen, Radix Glycyrrhizae, the leaf of bamboo.Few through closing breast.These product stimulate the menstrual flow lactogenesis.With controlling blood stasis through closing, join safflower, peach kernel, the equivalent use of the red sage root; If deficient or obstructed with controlling milk, can being equal to the seed of cowherb, pangolin and using; These product can also sharp blood vessels, get round by bribery, join ramulus mori, coix seed is equal to use, treatment damp-heat arthralgia pain.
Rhizoma cyperi: pungent micro-hardship is sweet, flat, enter liver, tri-jiao channel.The distending pain in hypochondrium; Spargosis is educated; Hernia pain; Irregular menstruation; The full pain of gastral cavity abdomen ruffian; Belch acid regurgitation, evil of vomitting; Dysmenorrhea; Under uterine bleeding band; Fetal irritability.
Donkey-hide gelatin: sweet is flat.Return lung, liver, kidney channel.Function cures mainly: enriching yin of enriching blood, and moisturizes, hemostasis.Sallow for the deficiency of blood, dizzy palpitaition, flesh impotence is unable, dysphoria and insomnia, endogenous deficient wind, xeropulmonary cough, and labor is coughed spitting of blood, haematemesis hematuria, uterine bleeding of having blood in stool, vaginal bleeding during pregnancy.
Cactus: bitter, cool.Function cures mainly: clearing heat and detoxicating, eliminating stasis to subdue swelling, benefiting stomach and stopping pain, antibechic.For taste-blindness rate, acute dysentery, cough; Mumps is controlled in external application, mastitis, carbuncle furuncle poison, snake bite, burn and scald.
Crape myrtle: micro-hardship, puckery, flat.Function cures mainly: invigorate blood circulation, hemostasis, removing toxic substances, detumescence.For various hemorrhage, fracture, mastitis, eczema, hepatitis, cirrhotic ascites.
Dried orange peel: warm in nature, taste is pungent, bitter; Return spleen, lung channel, for diseases such as fullness and oppression of chest and abdomen.The pungent loose logical temperature of orange peel, fragrant odour, is longer than and regulates the flow of vital energy, spleen lung can be entered, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of qi wide in, gather around the diseases such as stagnant, chest diaphragm ruffian full and the taste stagnation of the circulation of vital energy, abdominal fullness and distention for lung qi, for damp retention in middle-jiao, gastral cavity abdomen ruffian is swollen, have loose bowels in loose stool, and the disease such as many coughs of phlegm.Orange peel dispelling dampness with bitter and warm-natured drugs and can invigorating the spleen promoting the circulation of qi, therefore be usually used in the diseases such as damp retention in middle-jiao, gastral cavity abdominal distension is vexed, loose stool tongue is greasy, can compatibility rhizoma atractylodis, the bark of official magnolia is with using.Being good at again eliminating dampness and eliminating phlegm, stopping up the conventional key medicine of lung, the many coughs of phlegm for controlling wet phlegm, reduce for insufficiency of the spleen diet, indigestion, and the disease such as n and V.This product eliminating dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and the stomach, diet minimizings, indigestion, stool diarrhea, often and the fit applications such as ginseng, the bighead atractylodes rhizome, Poria cocos.Because it can invigorating the spleen, can regulate the flow of vital energy again, therefore the assistant being often used as Qi-tonifying drug makes, and can make tonify without causing stagnation, prevent heap soil or fertilizer over and around the roots from holding back and do swollen effect, in addition, orange peel again can with in, stomach Qi rising, n and V can be controlled.
Gorgon fruit: taste is sweet, puckery, property is put down.Cure mainly rheumatic arthritis, back goinyalgia.Tonifying middle-Jiao and Qi, strong will of refreshing oneself, makes people's normal hearing and eyesight.It is not hungry that clothes of a specified duration make people make light of one's life by commiting suicide.Can also whet the appetite and help gas and kidney tonifying, control frequency of micturition, seminal emission, purulent leukorrhea.Make powder to eat, beneficial people.But children's should not eat more, not beneficial taste, are difficult to digestion.
The membrane of a chicken's gizzard: sweet, cold, return spleen, stomach, small intestine, urinary bladder channel, for food digesting stomach fortifying, arresting seminal emission.The membrane of a chicken's gizzard is containing gastric hormone, keratin, amino acid and micro-pepsin, amylase etc.After oral the membrane of a chicken's gizzard powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and stomach motion is strengthened, emptying quickening.Its acid extractants liquid or decoction can accelerate to get rid of radiostrontium from urine.
Divine Comedy: record according to " the southern regions of the Yunnan Province book on Chinese herbal medicine ", Divine Comedy can " hold up taste to enter diet, disappear the food stopped every place in stomach ".Divine Comedy is containing volume saccharomycete, and B family vitamin, also containing multiple B family vitamin in cerevisin, therefore Divine Comedy has the effect of B family vitamin sample.As improved a poor appetite, maintain normal stool function etc.
Hawthorn: section is dried, put in pot large stir-fry of useing force and be degree to outside Jiao's brown, inner yellowish-brown, spray clear water, taking-up is dried, and is charred FRUCTUS CRATAEGI.There is appetite-stimulating indigestion-relieving, change effect of stagnant long-pending, the promoting blood circulation to remove blood stasis of disappearing, promoting the circulation of qi of reducing phlegm, meridian distribution of property and flavor, sour, sweet, slightly warm in nature.Main component is containing chlorogenic acid, caffeic acid, crataegolic acid, neat chrysanthemum tartaric acid, Quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin etc.Oral hawthorn can increase digestive ferment, promotes decomposition and the digestion of fat, to because of eat meat or greasy too much caused by abdominal fullness and distention, belch, do not feel like eating, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines test shows, hawthorn has slow and lasting effect reduced blood pressure, and also can reduce cholesterol and triglycerides, atherosclerosis, but also can diastole coronary artery, increases myocardial contractive power, to anti-arrhythmia.Therefore, be conducive to preventing and treating hypertension, high fat of blood, artery sclerosis and coronary heart disease.
Chinese medicine additive of the present invention also comprises: ant, radix bupleuri, glossy ganoderma and rhodiola root.
Ant: taste is salty; Acid; Property is put down.Return liver; Kidney channel.Function cures mainly: tonifying kidney and benefiting sperm; Clearing and activating the channels and collaterals; Removing toxicity for detumescence.Main dizzy tinnitus of suffering from a deficiency of the kidney; Insomnia and dreamful sleep; Impotence and seminal emission; Arthralgia due to wind-dampness; Hemiplegia 6; Numb in every limb; Erythematosus lupus; Chorionitis; Dermatomyositis; Carbuncle swells furunculosis; Venomous snake bite.
Radix bupleuri: clearind deficient heat Chinese medicine, comes off for cold, fever, fevers and chills alternate, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, uterus, irregular menstruation.Radix bupleuri begins to be loaded in Shennong's Herbal, is classified as top grade.Promote immunity function, active ingredient: Bupleurum chinense polysaccharide.Effect: phagocytic function strengthens, Natural killer activity strengthens, and improves special viral antibody titre, improves lymphocyte and turns core rate, improve skin delayed hypersensitivity reaction.Anti-liver injury, Bupleurum injection (concentration 1: a 1) 1 ml/ hypodermic injection significantly can reduce the rat blood serum GPT that carbon tetrachloride causes for continuous 5 days and raise, degeneration of liver cells and necrosis also obviously alleviate, and in liver cell, glycogen and rna content are also close to normal.
Glossy ganoderma: property is sweet, flat.The thoughts of returning home, lung, liver, kidney channel.Cure mainly consumptive disease, cough, asthma, insomnia, indigestion, malignant tumour etc.Animal pharmacology shows experiment: glossy ganoderma has inhibitory action to nervous system, and the circulatory system has step-down and strengthens the effect of cardiac contractile force, has phlegm-dispelling functions to respiratory system, in addition, protects liver in addition, improves immunologic function, antibacterially waits effect.
Rhodiola root: sweet, puckery, cold.Function cures mainly: removing heat from the lung to relieve cough, hemostasis, only band.For cough with lung heat, spitting of blood, leukorrhea; Traumatic injury is controlled in external application, burn and scald.Tonifying Qi clearing lung-heat; Intelligence development is nourished heart; Controlling of bleeding with astringents; Eliminating stasis to subdue swelling.Main deficiency of vital energy and physically weak; Chilly after being ill; Shortness of breath and fatigue; Cough with lung heat; Spitting of blood; Leukorrhea is suffered from diarrhoea; Traumatic injury; Burn and scald; Neurosis; Altitude sickness.
Embodiment 1 feed 1
The embodiment of the present invention 1 provides a kind of feed being used for the treatment of mastitis for milk cows, and feed is made up of the raw material of following parts by weight: barley 65 weight portion, oat 55 weight portion, soybean 35 weight portion, peanut meal 25 weight portion, clover dry powder 25 weight portion, pomelo peel 15 weight portion, needle mushroom dreg 15 weight portion, Kelp Powder 15 weight portion and Chinese medicine additive 15 weight portion.
Wherein, Chinese medicine additive is made up of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portion, Radix Codonopsis 15 weight portion, finelydivided phtheirospermum root 13 weight portion, Radix Angelicae Sinensis 15 weight portion, bitter leaves 20 weight portion, notopterygium root 17 weight portion, Radix Isatidis 13 weight portion, Ligusticum wallichii 17 weight portion, meropodium pearl 13 weight portion, Boston ivy 13 weight portion, orange peel 15 weight portion, the fragrant 17 amount parts of bodhi, Radix Glycyrrhizae 16 weight portion, wilsonii 15 weight portion, akebi 12 weight portion, rhizoma cyperi 13 weight portion, donkey-hide gelatin 12 weight portion, cactus 13 weight portion, crape myrtle 15 weight portion, dried orange peel 14 weight portion, Gorgon fruit 13 weight portion, the membrane of a chicken's gizzard 13 weight portion, Divine Comedy 18 weight portion and hawthorn 13 weight portion.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, mixes in proportion by all raw medicinal materials, is ground into 100 object powder, adds the water relative to mixture quality 5 times, at the temperature of 90 DEG C, decocts 30 minutes, and decoction liquor is filtered, and obtains the first filtered fluid and filter residue;
Second step, adds the water relative to first step mixture quality 3 times by the filter residue that the first step obtains, at the temperature of 90 DEG C, decocts 1 hour, and decoction liquor is filtered, and obtains the second filtered fluid;
3rd step, the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that EAT is at 190 DEG C, leaving air temp 80 DEG C, is ground into 200 orders subsequently, obtains Chinese medicine additive powder.
Embodiment 2 Chinese medicine additive 2
Embodiments provide a kind of feed being used for the treatment of mastitis for milk cows, feed is made up of the raw material of following parts by weight: barley 62 weight portion, oat 49 weight portion, soybean 39 weight portion, peanut meal 24 weight portion, clover dry powder 24 weight portion, pomelo peel 13 weight portion, needle mushroom dreg 12 weight portion, Kelp Powder 13 weight portion and Chinese medicine additive 13 weight portion.
Wherein, Chinese medicine additive is made up of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portion, Radix Codonopsis 15 weight portion, finelydivided phtheirospermum root 13 weight portion, Radix Angelicae Sinensis 15 weight portion, bitter leaves 20 weight portion, notopterygium root 17 weight portion, Radix Isatidis 13 weight portion, Ligusticum wallichii 17 weight portion, meropodium pearl 13 weight portion, Boston ivy 13 weight portion, orange peel 15 weight portion, the fragrant 17 amount parts of bodhi, Radix Glycyrrhizae 16 weight portion, wilsonii 15 weight portion, akebi 12 weight portion, rhizoma cyperi 13 weight portion, donkey-hide gelatin 12 weight portion, cactus 13 weight portion, crape myrtle 15 weight portion, dried orange peel 14 weight portion, Gorgon fruit 13 weight portion, the membrane of a chicken's gizzard 13 weight portion, Divine Comedy 18 weight portion, hawthorn 13 weight portion, ant 13 weight portion, radix bupleuri 17 weight portion, glossy ganoderma 12 weight portion and rhodiola root 13 weight portion.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, mixes in proportion by all raw medicinal materials, is ground into 150 object powder, adds the water relative to mixture quality 4 times, at the temperature of 95 DEG C, decocts 45 minutes, and decoction liquor is filtered, and obtains the first filtered fluid and filter residue;
Second step, adds the water relative to first step mixture quality 2 times by the filter residue that the first step obtains, at the temperature of 95 DEG C, decocts 45 minutes, and decoction liquor is filtered, and obtains the second filtered fluid;
3rd step, the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that EAT is at 180 DEG C, leaving air temp 70 DEG C, is ground into 300 orders subsequently, obtains Chinese medicine additive powder.
Embodiment 3 paste
Embodiments provide a kind of medicine being used for the treatment of mastitis for milk cows, be made up of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portion, Radix Codonopsis 15 weight portion, finelydivided phtheirospermum root 13 weight portion, Radix Angelicae Sinensis 15 weight portion, bitter leaves 20 weight portion, notopterygium root 17 weight portion, Radix Isatidis 13 weight portion, Ligusticum wallichii 17 weight portion, meropodium pearl 13 weight portion, Boston ivy 13 weight portion, orange peel 15 weight portion, the fragrant 17 amount parts of bodhi, Radix Glycyrrhizae 16 weight portion, wilsonii 15 weight portion, akebi 12 weight portion, rhizoma cyperi 13 weight portion, donkey-hide gelatin 12 weight portion, cactus 13 weight portion, crape myrtle 15 weight portion, dried orange peel 14 weight portion, Gorgon fruit 13 weight portion, the membrane of a chicken's gizzard 13 weight portion, Divine Comedy 18 weight portion, hawthorn 13 weight portion, ant 13 weight portion, radix bupleuri 17 weight portion, glossy ganoderma 12 weight portion and rhodiola root 13 weight portion.
The embodiment of the present invention additionally provides a kind of preparation method being used for the treatment of the medicine of mastitis for milk cows, and medicine is paste, and preparation method comprises the following steps:
Take all raw medicinal materials by weight and soak 1.5 hours, be then placed in multi-function extractor, first time decocts 7 times that amount of water is medicinal material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release liquid, put in fluid reservoir; Second time decocts, and amount of water is medicinal material 7 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract liquid out, merge with the liquid that decocts of first time; To merge in the decoction liquor suction reduced pressure concentration tank of latter 2 times, be decompressed to 0.05MPa, temperature remains on 70 DEG C, and being concentrated into relative density is 1.20, the medicinal extract of temperature to 65 DEG C, cooling; The pearl powder getting medicinal extract weight 10% adds in medicinal extract, stirs, tinning after Ultraviolet radiation sterilizing.
Toxicity test
1, cumulative toxicity test report
Select 20 healthy mices, female, each 10 of hero, with the Chinese medicine additive of the embodiment of the present invention 1 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.With the Chinese medicine additive of embodiment 2 for object, carry out toxicity test according to the method described above, result is as identical in embodiment 1.
2, acute toxicity test
Application NIH mouse 40, SPF level, male and female half and half, body weight 16 ~ 20g, carries out acute toxicity test.Mouse is divided into two groups at random, often organizes 20, i.e. control group and administration group, fasting 12 hours before experiment; Chinese medicine additive prepared by embodiments of the invention 1 is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), control group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mouse.Experimental result shows: compare with control group, and after administration, mouse has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.The powder 1LD50>32.9 crude drug/kg of the Mouse oral gavage embodiment of the present invention 1, every day, maximum dosage-feeding was 65.8g crude drug/kg/ day.The clinical application amount of the Chinese medicine additive of the embodiment of the present invention 1 be 3g crude drug/day/head, pig weight is in 6kg, and average dosage is 0.5g crude drug/kg/ day.By batheroom scale: the dosis tolerata of the Chinese medicine additive of mouse (average weight is in 20g) the oral administration gavage embodiment of the present invention 1 is 131 times of quantity.Therefore the acute toxicity of the Chinese medicine additive of the embodiment of the present invention 1 is low, clinical drug safety.With the Chinese medicine additive of embodiment 2 for object, carry out toxicity test according to the method described above, result is as identical in embodiment 1.
3, external application acute skin irritation test
These product are according to 6.3 joints in the Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, the paste getting the 0.5g embodiment of the present invention 3 directly to spread upon on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.
4, external application acute dermal toxicity test
These product are according to the Ministry of Public Health " cosmetics health specification " (2002) Part II " acute dermal toxicity test " test method(s) of once limiting the quantity, SD rat 20, male and female half and half, body weight 90g ~ 180g, by the paste of the embodiment of the present invention 3, once smears 5000mg/kg body weight dose through skin, observe 15 days, do not find obvious poisoning symptom, without dead, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.
Clinical testing
(1) animal used as test
Animal used as test 160 of providing for certain cattle farm suffer from the milk cow of mammitis after diagnosing.Tested on May 21,6 days to 2012 May in 2012, duration of test carries out daily feeding and management by cattle farm Routine Management way.
(2) test method
160 ill milk cows are divided into four experimental group at random, often organize 40, four experimental group use the feed (embodiment group 2) of the feed of the embodiment of the present invention 1 (embodiment group 1), embodiment 2, the feed of embodiment 2 and the paste of embodiment 3 jointly to use (embodiment group 3) and conventional medicament (control group) to treat respectively.In embodiment group 3, paste coordinates the feed of embodiment 2 to use, and every day smeared twice by paste, uses 8-15 days continuously.
(3) criterion of therapeutical effect
Clinical testing of the present invention adopts California mammitis detection method (CMT) determination methods to provide curative effect determinate standard, as shown in table 1, and wherein efficient is the summation of " recovery from illness " and " improvement "; California mammitis detection method (CMT) determination methods and standard as shown in table 2.
Table 1 clinical testing curative effect determinate standard of the present invention
Table 2 California mammitis detection method (CMT) determination methods and standard
(4) result for the treatment of
Result is as shown in table 1, from result for the treatment of, adopts feed of the present invention to be more than 90% to the treated effect of mastitis for milk cows.
From the data of table 1, compared with control group, use the feed of the embodiment of the present invention 1 and embodiment 2 treatment mastitis for milk cows to have evident in efficacy, that cure rate is high advantage, both externally used paste of the present invention and feed are especially obvious with the use of effect; Find in long-term observation subsequently, embodiment group 1, embodiment group 2 and embodiment group 3 recovery from illness milk cow again the incidence of disease be starkly lower than the milk cow of control group.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (2)
1. be used for the treatment of the feed of mastitis for milk cows, it is characterized in that, described feed is made up of the raw material of following parts by weight: barley 50-70 weight portion, oat 40-60 weight portion, soybean 30-50 weight portion, peanut meal 20-30 weight portion, clover dry powder 20-30 weight portion, pomelo peel 10-15 weight portion, needle mushroom dreg 10-15 weight portion, Kelp Powder 10-15 weight portion and Chinese medicine additive 5-17 weight portion;
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, finelydivided phtheirospermum root 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, bitter leaves 15-25 weight portion, notopterygium root 10-25 weight portion, Radix Isatidis 10-16 weight portion, Ligusticum wallichii 13-20 weight portion, meropodium pearl 10-15 weight portion, Boston ivy 10-15 weight portion, orange peel 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, wilsonii 10-20 weight portion, akebi 10-15 weight portion, rhizoma cyperi 10-15 weight portion, donkey-hide gelatin 10-15 weight portion, cactus 10-15 weight portion, crape myrtle 10-20 weight portion, dried orange peel 10-20 weight portion, Gorgon fruit 10-15 weight portion, the membrane of a chicken's gizzard 10-15 weight portion, Divine Comedy 15-20 weight portion and hawthorn 10-15 weight portion.
2. the feed being used for the treatment of mastitis for milk cows according to claim 1, it is characterized in that, described feed is made up of the raw material of following parts by weight: barley 55-65 weight portion, oat 45-55 weight portion, soybean 35-45 weight portion, peanut meal 23-25 weight portion, clover dry powder 22-25 weight portion, pomelo peel 10-15 weight portion, needle mushroom dreg 10-15 weight portion, Kelp Powder 10-15 weight portion and Chinese medicine additive 9-17 weight portion.
3
.the feed being used for the treatment of mastitis for milk cows according to claim 1, is characterized in that, described Chinese medicine additive also comprises: ant, radix bupleuri, glossy ganoderma and rhodiola root, described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, finelydivided phtheirospermum root 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, bitter leaves 15-25 weight portion, notopterygium root 10-25 weight portion, Radix Isatidis 10-16 weight portion, Ligusticum wallichii 13-20 weight portion, meropodium pearl 10-15 weight portion, Boston ivy 10-15 weight portion, orange peel 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, wilsonii 10-20 weight portion, akebi 10-15 weight portion, rhizoma cyperi 10-15 weight portion, donkey-hide gelatin 10-15 weight portion, cactus 10-15 weight portion, crape myrtle 10-20 weight portion, dried orange peel 10-20 weight portion, Gorgon fruit 10-15 weight portion, the membrane of a chicken's gizzard 10-15 weight portion, Divine Comedy 15-20 weight portion, hawthorn 10-15 weight portion, ant 10-16 weight portion, radix bupleuri 15-20 weight portion, glossy ganoderma 10-15 weight portion and rhodiola root 10-15 weight portion.
4
.the feed being used for the treatment of mastitis for milk cows according to claim 3, it is characterized in that, described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, finelydivided phtheirospermum root 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, bitter leaves 18-22 weight portion, notopterygium root 15-20 weight portion, Radix Isatidis 12-14 weight portion, Ligusticum wallichii 15-18 weight portion, meropodium pearl 12-14 weight portion, Boston ivy 12-14 weight portion, orange peel 13-18 weight portion, the fragrant 16-18 of bodhi measures part, Radix Glycyrrhizae 15-18 weight portion, wilsonii 13-18 weight portion, akebi 11-14 weight portion, rhizoma cyperi 12-14 weight portion, donkey-hide gelatin 11-14 weight portion, cactus 11-14 weight portion, crape myrtle 12-18 weight portion, dried orange peel 12-17 weight portion, Gorgon fruit 11-14 weight portion, the membrane of a chicken's gizzard 11-14 weight portion, Divine Comedy 17-19 weight portion, hawthorn 12-14 weight portion, ant 12-14 weight portion, radix bupleuri 16-19 weight portion, glossy ganoderma 11-13 weight portion and rhodiola root 11-14 weight portion.
5
.the feed being used for the treatment of mastitis for milk cows according to any one of claim 1-4, is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step, mixes in proportion by all raw medicinal materials, is ground into 100 order ~ 200 object powder, add the water relative to mixture quality 3 ~ 5 times, at the temperature of 90 DEG C ~ 100 DEG C, decoct 30 minutes ~ 1 hour, decoction liquor is filtered, and obtains the first filtered fluid and filter residue;
Second step, adds the water relative to first step mixture quality 1 ~ 3 times by the filter residue that the first step obtains, at the temperature of 90 DEG C ~ 100 DEG C, decocts 30 minutes ~ 1 hour, and decoction liquor is filtered, and obtains the second filtered fluid;
3rd step, the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, is ground into 200 order ~ 400 orders subsequently, obtains Chinese medicine additive powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310722973.1A CN103652501B (en) | 2013-12-25 | 2013-12-25 | Feed for treating cow mastitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310722973.1A CN103652501B (en) | 2013-12-25 | 2013-12-25 | Feed for treating cow mastitis and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103652501A CN103652501A (en) | 2014-03-26 |
| CN103652501B true CN103652501B (en) | 2015-01-07 |
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| CN104187053A (en) * | 2014-07-24 | 2014-12-10 | 宿州市草源牧业股份有限公司 | Composite feed for preventing dairy cow mastitis |
| CN104286381A (en) * | 2014-09-09 | 2015-01-21 | 李翠和 | Feed for preventing lactating cattle mastitis |
| CN104855735A (en) * | 2015-06-11 | 2015-08-26 | 山东新希望六和集团有限公司 | Feed used for cows postpartum and preparation method thereof |
| CN105166546A (en) * | 2015-09-25 | 2015-12-23 | 山东新希望六和集团有限公司 | Milk cow compound feed and making method thereof |
| CN105707463A (en) * | 2016-04-28 | 2016-06-29 | 青岛海之星生物科技有限公司 | Enteromorpha feed for dairy cattle and preparation method thereof |
| CN105920316B (en) * | 2016-06-29 | 2019-09-24 | 河北省畜牧兽医研究所 | The Chinese materia medica preparation for improving milk cow immunity, preventing mastitis for milk cows |
| CN105998618B (en) * | 2016-06-29 | 2019-09-24 | 河北省畜牧兽医研究所 | Improve the preparation method of milk cow immunity, the Chinese materia medica preparation for preventing mastitis for milk cows |
| CN106578346A (en) * | 2016-12-29 | 2017-04-26 | 青岛嘉瑞生物技术有限公司 | Technology of using froggrass to prepare dairy cow fermented feed through bioanalysis |
| CN106879828A (en) * | 2017-03-27 | 2017-06-23 | 上海华扩达生化科技有限公司 | A kind of feed formula and processing method for improving animal immune performance |
| CN107594156A (en) * | 2017-10-25 | 2018-01-19 | 韦俊 | A kind of feed addictive for preventing mastitis for milk cows and its application |
| CN113117029A (en) * | 2021-04-22 | 2021-07-16 | 章国忠 | Traditional Chinese medicine composition for reducing somatic cell count in milk and preparation method thereof |
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| CN101385514A (en) * | 2008-10-22 | 2009-03-18 | 李爱华 | Efficient full-day cubed feed for barn feeding cattle and production method thereof |
| CN102125182B (en) * | 2011-01-07 | 2012-07-11 | 山东省农业科学院农业资源与环境研究所 | Needle mushroom fungus dreg feed for dairy cow |
| CN102940719A (en) * | 2012-09-05 | 2013-02-27 | 河北科技师范学院 | Chinese herbal medicine feed additive for treating dairy cow mastitis |
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