CN107998242A - A kind of Chinese medicine composition for treating mastitis for milk cows and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating mastitis for milk cows and preparation method thereof Download PDFInfo
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- CN107998242A CN107998242A CN201711210249.5A CN201711210249A CN107998242A CN 107998242 A CN107998242 A CN 107998242A CN 201711210249 A CN201711210249 A CN 201711210249A CN 107998242 A CN107998242 A CN 107998242A
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Abstract
A kind of composition for treating mastitis for milk cows and preparation method thereof；Said composition is made of pangolin, honeysuckle, the bark of ash, dandelion, semiaquilegia adoxoides, Radix Salviae Miltiorrhizae, Ligusticum wallichii, Cortex Magnoliae Officinalis, Fructus Forsythiae, luffa, Chinese violet, radix astragali, Angelica sinensis, the seed of cowherb, radix glycyrrhizae, rhizoma cyperi, and above-mentioned raw materials are soaked, boils and forms；This composition materials are extensive, of low cost, easy to use, safe effectively, there is invigorate blood circulation, dissipating blood stasis and reducing the stagnation, antibacterial anti-inflammatory, the newborn network of dredging, belong to non-specific antimicrobial, not only there is directly antibacterial, sterilization, not the advantages of not producing drug resistance, and have the effect of resistance and immunity for strengthening body.
Description
Technical field
The invention belongs to animal medicinal composition, more particularly to be a kind of Chinese medicine composition and its system for treating mastitis for milk cows
Preparation Method.
Background technology
Mastitis for milk cows is the important diseases for endangering milk cattle cultivating, and huge harm and economic damage are caused to Cow product
Lose.Mastitis for milk cows refers to the inflammation of the cow breast as caused by the various causes of disease, in economic loss caused by mammitis, due to
The output of milk accounts for the 70% of loss caused by reducing, and makes what milk cow did sth. in advance to eliminate to account for 14% due to diseased, discarded milk accounts for 10%.
In a cows, most mammitises are recessive types, therefore cause mainly recessive mastitis, its loss of economic loss to account for
The 10%~11% of the annual total productive capacity of every lactating cow.Microbiological factor, environmental factor, Milking Methods And Techniques etc. can draw
Mastitis for milk cows is played, such as the infection of Streptococcusagalactiae and staphylococcus aureus, milker do not sterilize, milking person's misoperation
Deng.In addition, for high yield cow, though the daily ration of high-energy, high protein is conducive to protect and improve the output of milk, also increase at the same time
The load of breast, makes the resistance of body reduce, so as to trigger mammitis.
The infected cattle clinical manifestation for suffering from mastitis for milk cows changes for milk color, and milk is thin, wherein having floccule, coagulating
Block and a large amount of leucocytes or into serum sample, the acute swelling of ill breast district, rubefaction, the fever of palpation breast, swelling, have lump,
Pain sensitivity, for acute generalised mammitis, if effectively treatment not in time, can jeopardize affected animal life.
It is many to treat mastitis for milk cows method, has been summed up：1. whole body application antibiosis extract for treating eliminates the cause of disease of infection
Body, such as penicillin, streptomysin, erythromycin, sulfa drugs；2. intramammary injection antibiotic etc..These methods exist certain
Therapeutic effect, but there is also shortcomings, for example, long-term, high-dose causes antibody-resistant bacterium to increase using antibiotic, tetracycline,
The application of the antibiotic such as erythromycin can influence Immune Function, cause organism infection complicated symptoms, antibiotic is in breast
Residual in juice can directly influence the health of people, prevent medicine from being combined with protein to reduce drug effect, medicine after intramammary injection
Thing will have a longer half-life period in vivo, abandon newborn phase extension after causing medication, cause economic loss.And Chinese herbal treatment breast
Inflammation, short treating period is quick, economical and practical, and Chinese herbal medicine not only has antibacterial, antivirus action, also has the work for adjusting body function
With.Therefore it is trend of the times to apply Chinese medicine or explore other effective treatment methods having no toxic side effect.
The content of the invention
The purpose of the present invention aiming at above-mentioned treatment mastitis for milk cows there are the problem of, research and development one kind treat milk cow
Chinese medicine composition of mammitis and preparation method thereof, reaches and increases substantially mastitis for milk cows cure rate, and of low cost, nothing
The purpose of toxic side effect；The invention also discloses the preparation method of the Chinese medicine composition.
The technical scheme is that：A kind of Chinese medicine composition for treating mastitis for milk cows, is matched somebody with somebody by following raw materials and consumption
System：Pangolin 5-10g, honeysuckle 20-30g, bark of ash 20-30g, dandelion 20-30g, semiaquilegia adoxoides 10-20g, Radix Salviae Miltiorrhizae 10-20g, river
Rhizome of chuanxiong 10-20g, Cortex Magnoliae Officinalis 10-20g, Fructus Forsythiae 20-30g, luffa 10-20g, Chinese violet 10-20g, radix astragali 10-20g, Angelica sinensis
10-20g, seed of cowherb 10-20g, radix glycyrrhizae 10-20g, rhizoma cyperi 10-20g.
Preferably, a kind of Chinese medicine composition for treating mastitis for milk cows, said composition are prepared by following raw materials and consumption：Wear
7-9 parts of naze, 22-27 parts of honeysuckle, 21-27 parts of the bark of ash, 23-26 parts of dandelion, 12-18 parts of semiaquilegia adoxoides, 13-15 parts of Radix Salviae Miltiorrhizae, river
12-17 parts of rhizome of chuanxiong, 13-19 parts of Cortex Magnoliae Officinalis, 22-26 parts of Fructus Forsythiae, 12-18 parts of luffa, 11-19 parts of Chinese violet, radix astragali 12-18
Part, 12-18 parts of Angelica sinensis, 11-18 parts of the seed of cowherb, 12-18 parts of radix glycyrrhizae, 13-18 parts of rhizoma cyperi, 50-58 parts of fig.
Preferably, a kind of Chinese medicine composition for treating mastitis for milk cows, said composition are prepared by following raw materials and consumption：Wear
8 parts of naze, 25 parts of honeysuckle, 24 parts of the bark of ash, 25 parts of dandelion, 17 parts of semiaquilegia adoxoides, 14 parts of Radix Salviae Miltiorrhizae, 15 parts of Ligusticum wallichii, 18 parts of Cortex Magnoliae Officinalis,
25 parts of Fructus Forsythiae, 13 parts of luffa, 15 parts of Chinese violet, 17 parts of radix astragali, 15 parts of Angelica sinensis, 15 parts of the seed of cowherb, 17 parts of radix glycyrrhizae, perfume
Attached 16 parts, 56 parts of fig.
Present invention also offers a kind of Chinese medicine composition preparation method for treating mastitis for milk cows, comprise the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water
Solid-liquid ratio is 1: 1.6-1.9, carries out ultrasonication, then as fermenting under the conditions of 25-35 DEG C, in fermentation process at microwave
Reason, ferments 1-3 days and filters, obtain fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds complex enzyme and 2 parts of water, digested, isolate supernatant and solid
Slag；Supernatant and solid slag are dried respectively, mixes, obtains fiber；
(3) medicament is prepared：Weigh except other raw materials of fig mix；2500~3000 are added into the medicament mixed
Part normal-temperature water, soaks 30 minutes；After boiling by intense fire, continue to decoct 40~50 minutes using slow boiling, filtering, obtains the dregs of a decoction and a medicine
Liquid；2000~2500 parts of normal-temperature waters are added into the dregs of a decoction, using being cooked by slow fire 40~45 minutes, filters, obtains secondary liquid；
Liquid and secondary liquid are merged, add the fiber that step 2 obtains, that is, obtains the Chinese medicine of one treatment mastitis for milk cows
Composition.
Preferably, the condition of the ultrasonication is 20-25kHz, power 200-280W, time 0.5-1h.
Preferably, acetobacter and glucose oxidation and bacillus are added in the fermentation described in step (1), acetobacter and
Glucose oxidation and bacillus additive amount is the 0.5% and 0.3% of fig weight respectively.
Preferably, the condition of the microwave treatment is 1.05kHz, and power 500W, the time is daily 25s.
Preferably, the weight ratio of the fig and complex enzyme is 100: 0.5-2；The complex enzyme is fig egg
White enzyme, papain, the mixture of glucoamylase, ficin, papain, the matter of glucoamylase
Amount is than being 2: 1: 5.
Core drug in the Chinese medicine composition for the treatment of mastitis for milk cows of the present invention includes honeysuckle, the bark of ash, Pu
Public English：(1) honeysuckle energy antibacterial anti-inflammatory, antipyretic, antagonism and the pathogenic microorganism for suppressing to cause mastitis for milk cows.Can also and it improve
The immunity of body.(2) bark of ash has mammitis anti-inflammatory, analgesic activity, and has bacteriostasis, can act synergistically with honeysuckle.
(3) dandelion has stronger bacteriostasis, and the immune function of energy excitating organism, can act synergistically with honeysuckle and the bark of ash.
Remove above-mentioned core drug, the other medicines in composition, such as pangolin, the seed of cowherb and Fructus Forsythiae, breast under promoting menstruation,
The effect of anti-stain in solid is stronger, particularly the seed of cowherb, is particularly suitable for agalactia, acute mastitis swelling and pain, the dredging of postpartum thymus gland, leaching
Puckery pain is demonstrate,proved, is the important medicine of clinical common lower breast.Cryptotanshinone, dihydrotanshinone in Radix Salviae Miltiorrhizae, to staphylococcus, large intestine bar
Bacterium, denaturation bacillus have a stronger inhibitory action, and the magnolol in Cortex Magnoliae Officinalis has strong antibacterial action, for including staphylococcus, haemolysis
Property streptococcus including bacterium have and acted on compared with high inhibition, the two, which is combined, can effectively suppress the micro- life of cause of disease that causes mastitis for milk cows
Thing.Chinese violet and Angelica sinensis can give full play to antibacterial and anti-inflammation functions, the two inflammatory reaction with reference to caused by can alleviate inflammation.Ligusticum wallichii
There are calm, analgesic, bacteriostasis, rhizoma cyperi improves the threshold of pain, Ligusticum wallichii can be cooperateed with to ease pain.Radix astragali has invigorating qi for consolidating superficies, the work(of cardiac stimulant profit water
Effect, moreover it is possible to improve immunity, while bacteriostasis can also be played.Radix glycyrrhizae is also right in addition to can be with anti-inflammatory, enhancing immunity of organisms
Chinese medicine composition plays flavored action.
The pharmacological action of various Chinese medicines in the Chinese medicine composition for the treatment of mastitis for milk cows of the present invention：
(1) pangolin：Breast, anti-stain in solid under blood circulation promoting and dispersing pathogen accumulation, promoting menstruation.Treat blood stasis, abdominal mass, arthralgia pain due to rheumatism, milk
Under not, carbuncle swells, scrofula.
The decocting liquid of pangolin piece plays the role of being obviously prolonged the big white mouse clotting time and reduces big white mouse blood viscosity
Effect.Aqueous extracts, the alcohol extract of pangolin piece have small white mouse ear inflammation effect caused by obvious anti-bar of oil oil.Pangolin
Cyclic dipeptides VI and VII in piece can improve the tolerance of small white mouse normobaric hypoxia.
(2) honeysuckle：It is clearing heat and detoxicating, dispelling wind and heat from the body.Treatment carbuncle swells treatment sore, larynx numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold,
Warm disease heating.
Honeysuckle is to various pathogens such as staphylococcus aureus, hemolytic streptococcus, Escherichia coli, shigella dysenteriae, suddenly
Random vibrios, typhoid bacillus, paratyphosum Bacterium etc. have certain inhibitory action, to pneumococcus, diplococcus meningitidis, green pus bar
Bacterium, tubercle bacillus are also effective.Honeysuckle also has obvious anti-inflammatory and refrigeration function, and honeysuckle flower water and steeping in wine liquid are to tentative swollen
Oncocyte has obvious lethal effect.Booster immunization function acts on, and promotes the phagocytic function of leucocyte.There is antiendotoxin work
With.
(3) bark of ash：Heat-clearing and damp-drying drug, inducing astrigency stop dysentery, stop-band, improving eyesight.Damp-heat dysentery is treated, with lower pruritus vulvae, leukorrhea with reddish discharge, mesh
Red swelling and pain, raw screen film of mesh.
Bark of ash decoction has suppression to make staphylococcus aureus, Escherichia coli, shigella flexneri, bacterium sonnei
With.Aesculin has inhibitory action to staphylococcus aureus, micrococcus catarrhalis, streptococcus, neisser's diplococcus, also have anti-inflammatory,
Analgesic activity.Fraxin has diuresis, can promote the excretion of rabbit and rheumatisant's uric acid.It can suppress Isolated Toad Heart
And isolated rabbit intestines, light contraction toad lower limb vascular.
(4) dandelion：Clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia.Treat furuncle swelling toxin, acute mastitis, scrofula, hot eyes, pharynx
Bitterly, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea.
This product decoction or preserved material, have staphylococcus aureus, hemolytic streptococcus and micrococcus catarrhalis stronger suppression to make
With also having to Diplococcus pneumopniae, diplococcus meningitidis, corynebacterium diphtheriae, shigella flexneri, Pseudomonas aeruginosa and Leptospira etc.
Certain inhibitory action.Still there are cholagogic, liver protection, antiendotoxin and diuresis.Dandelion aerial part water extract can activate
Macrophage, there is antitumor action.The immune function of energy excitating organism.
(5) semiaquilegia adoxoides：It is clearing heat and detoxicating, moisten the lung and relieve the cough, eliminating stasis to subdue swelling, promote the production of body fluid to quench thirst.Treat exogenous high fever, cough with lung heat, wound
The diseases such as sound of the wind is neighed, carbuncle sore tumefacting virus, treating swelling and pain by traumatic injury.
Contain in semiaquilegia adoxoides containing a variety of chemical compositions such as alkaloid, lactone, cumarin, phenolic constituent and amino acid, mainly into
Divide lactone and cyanogen glycosides compound that there is certain pharmacological activity.Semiaquilegia adoxoides contains the ferro element of hematopoiesis function, flavonoid
Thing, vitamin A etc..The component energy strengthen immunity such as contained Flavonoid substances, zinc, manganese and vitamin E in semiaquilegia adoxoides.Semiaquilegia adoxoides removes
Antioxidant ability of organism can be strengthened and removed outside free radical, there is antibacterial, anti-inflammatory, adjust blood pressure and blood lipoid and the pharmacology work(of anti-freezing
Energy.Semiaquilegia root extract is obvious to bacteriostasis under the conditions of specific pH and certain temperature, especially to Staphylococcus aureus
The fungistatic effect of bacterium is the most notable, is secondly bacillus subtilis and Escherichia coli, still, fungistatic effect of the semiaquilegia adoxoides to saccharomycete
It is only general, to aspergillus niger then without any fungistatic effect.Semiaquilegia adoxoides n-butanol extract can significantly improve normal mouse macrophage
Phagocytic index α, HC50, index and spleen index, prompt semiaquilegia adoxoides to strengthen the immune function of normal mouse.
(6) Radix Salviae Miltiorrhizae：Promoting blood circulation, inducing meastruation to relieve menalgia, cool blood to disappear carbuncle.Treat arthralgia pain due to rheumatism, uterine hemorrhage, haematemesis, mastitis,
Sore swell and ache curative.
Radix Salviae Miltiorrhizae energy coronary artery dilator, increases coronary flow, improves myocardial ischemia, infraction and cardiac function, adjusts the rhythm of the heart,
And peripheral blood vessel can be expanded, improve microcirculation；Shorten the convalescence of red blood cell and hemochrome, increase Reticulocyte, can promote
The reparation of tissue；Body's hypoxia tolerance, and anticoagulation can also be improved, promotes fibrinolytic, suppresses platelet aggregation, suppresses thrombus
The effect of formation, and the immune function of body can be strengthened.
(7) Ligusticum wallichii：Blood-activating and qi-promoting, wind-expelling pain-stopping.Treat chest impediment and cardialgia, chest side of body shouting pain, tumbling and swelling, addiction lump in the abdomen abdominal pain, head
Bitterly, traumatic injury, ulcer sores.
Rhizoma Chuanxiong extract ligustrazine has cardiac effect to whole animal ligustrazine, to animal brain when rhizoma chuanxiong volatile oil is a small amount of
It is movable inhibited, and there is excitation to medulla oblongata respiratory center, vasomotor center and spinal reflex maincenter.It is micro-
Uterus of becoming pregnant can be stimulated during amount, increases its tension force, shrinks enhancing.Ligusticum wallichii is to large intestine, dysentery (sonnei), deformation, green pus, wound
Cold, paratyphosum Bacterium and comma bacillus etc. have inhibitory action.Ligustrazine can also increase the renal blood flow of anesthetized rabbit, and can diuresis.
(8) Cortex Magnoliae Officinalis：Gas consumption product, eliminating dampness except full, relieving asthma, cure mainly stagnation of QI due to dyspepsia, abdominal distention constipation, damp retention in middle-jiao, gastral cavity
Ruffian vomiting and diarrhoea, phlegm stops up the circulation of vital energy in the wrong direction, chest full of cough.
The ether and methanolic extract of Cortex Magnoliae Officinalis have strong antibacterial action to cariogenic bacteria streptococcus mutans, its Antibacterial Constituents is true
It is set to magnolol.Experiment in vitro proves that Cortex Magnoliae Officinalis decoction is to gram positive bacterias such as staphylococcus, hemolytic streptococcus, pneumococcus
With bacillus anthracis, shigella dysenteriae, typhoid bacillus, paratyphosum Bacterium, comma bacillus, Escherichia coli, proteus, hay bacillus etc.
Gram negative bacilli has antibacterial action.In vitro, Cortex Magnoliae Officinalis to the inhibitory action of staphylococcus aureus compared with the coptis, radix scutellariae,
Rheum officinale is strong.Magnolol also has the function that to prevent irritability stomach dysfunction, and magnolol has special and holds with iso-agnolol
Long muscle relaxant activities.
(9) Fructus Forsythiae：Heat-clearing, removing toxic substances, dissipating bind, detumescence.Control warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching closes,
Control acute mastitis, newborn core.
Fructus Forsythiae has broad-spectrum antibacterial action, has very strong inhibitory action to staphylococcus aureus, Hayes shigella dysenteriae, to it
His pathogenic bacteria, influenza virus, fungi have certain inhibitory action.There is anti-inflammatory effect.Oleanolic acid contained by this product has cardiac stimulant, diuresis
And hypotensive activity, citrin can reduce vasopermeability and brittleness, prevent haemolysis.Decoction have anti-vomiting effect, dispelling wind and heat from the body,
Anti-liver injury acts on.
(10) luffa：Clearing and activating the channels and collaterals, removing toxicity for detumescence.For numbness pain contraction, distending pain in the chest and hypochondrium, alactation, phlegm-heat cough,
Heat toxin carbuncle swells,.
Luffa water decoction has obvious analgesic activity to the pain caused by chemistry, electricity, thermostimulation, its ease pain intensity and cranium
Pain is fixed similar；Spontaneous activity in mice can also be substantially reduced, and has good synergistic effect with subthreshold hypnotic dosage amobarbital；Together
When can also significantly mitigate rat paw edema degree caused by carrageenan, and have certain anti-inflammatory effect to granuloma induced by implantation of cotton pellets.
Luffa extract component plays the role of suppressing immune hemolysis and very strong anti-japanese encephalitis virus.
(11) Chinese violet：Clearing heat and detoxicating, cool blood detumescence, clearing heat and promoting diuresis, cure mainly furunculosis, carbuncle swells, scrofula, acute mastitis, jaundice,
Dysentery, diarrhea, hot eyes, larynx numbness, venomous snake bite.
Chinese violet has obvious antibacterial action, to tubercle bacillus, shigella dysenteriae, staphylococcus aureus, pneumococcus,
Dermatophyte and Leptospira have inhibitory action, and have exact antivirus action.It is demonstrated experimentally that its extracting solution is to endogenous toxic material
It is known as direct destruction effect.Chinese violet still has the effect such as antipyretic, anti-inflammatory, detumescence, its decocting liquid orally taken for curing acute tonsillotome
Inflammation, acute pneumonia, pulmonary heart disease pulmonary infection and surgery purulent inflammation.
(12) radix astragali：There is the effect of invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema, for spontaneous perspiration, night sweat, blood
Numbness, edema, un-festering of ulcer burst and do not hold back etc. disease long.
It can strengthen heart contraction, have cardiac effect to the heart of exhaustion.It can make coronary vasodilator and whole body peripheral vasodilation,
Thus decline blood pressure.There is diuresis.Play the role of strengthening capillary resistance, caused by can preventing histamine, chloroform
The increased phenomenon of capillary permeability, and the increased pathological phenomenon of capillary fragility caused by x-ray can be made multiple normal.Can occlusion
The secretory pit of skin, suppresses sweating, therefore has anti-hidropoiesis.There is class sex hormone.To shigella dysenteriae, bacillus anthracis, haemolysis
Property streptococcus, Diplococcus pneumopniae, staphylococcus aureus etc. have inhibitory action.
(13) Angelica sinensis：Replenishing and activating blood, menstruction regulating and pain relieving, moisturize laxation, cure mainly the deficiency of blood it is all card, abdominal mass knot gather, uterine bleeding, cold of insufficiency type abdomen
Bitterly, Impotence numbness, numbness, intestines are dry and shit is difficult, weight, ulcer sores, injury from falling down after dysentery characterized by blood in the stool.Being capable of Apocenosis pain relieving when controlling ulcer.
Chinese angelica volatile oil has direct repression, envoy to the isolated uterine of the animals such as rabbit, cavy, mouse, rat, dog
Rule property, which is shunk, to be tapered into disappearance, in relaxation state；And resist pituitrin, histamine, adrenaline and acetylcholine etc.
Caused uterine contractile.Contained volatile oil can be such that myocardial contraction frequency is substantially suppressed in Angelica sinensis decoction or root and leaf, it contains
There are many kinds of substance such as volatile oil, organic acid, amino acid, vitamin, trace element, body hematopoiesis function can be remarkably promoted, raise
Red blood cell, leucocyte and content of hemoglobin；Suppress platelet aggregation, antithrombotic, adjusts blood fat；Resist myocardial ischemia, the rhythm of the heart loses
Often, blood vessel is expanded, is reduced blood pressure；Adjust uterine smooth muscle.Also strengthen immune, anti-inflammatory, liver protection, anti-oxidant and removing free radical
Deng effect, can there is antibacterial action to external dysentery, typhoid fever, paratyphoid, Escherichia coli, comma bacillus etc..Angelica sinensis tune blood is
Dam key medicine, controls and is rushed on pregnant woman's postpartum extravesated blood, qi and blood can be made respectively to have returned.
(14) seed of cowherb：Invigorate blood circulation, lower breast detumescence, inducing diuresis for treating strangurtia.Suitable for agalactia, acute mastitis swelling and pain, postpartum
Thymus gland dredging, the puckery pain of stranguria, are the important medicines of clinical common lower breast.
Seed of cowherb aqua has contraction to rat uterus, has easing pain and diminishing inflammation effect to the wound of mouse；Also can dredge
Promoting lactation gland, is conducive to the milk outflow of accumulation in breast.
(15) radix glycyrrhizae：Invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moistens the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription.
Radix glycyrrhizae life, can purging intense heat and detonicating, relieving spasm to stop pain with cooler；Process and use partial temperature, exterior cold, tonifying middle-Jiao and Qi can be dissipated.Radix glycyrrhizae has class
Like adrenocortical hormones fuction, there is inhibitory action to gastroxia caused by histamine；And there are antiacid and alleviation stomach and intestine
Smooth muscle spasm acts on.Extract of licorice root and enoxolone have obvious antitussive effect, and phlegm-dispelling functions are also more significant；Contained by radix glycyrrhizae
Hypo acid can block Induced by Carcinogen tumour growth.In addition, radix glycyrrhizae is also good at mediation property of medicine, the poison of hundred medicines is solved, and has anti-inflammatory, resist
The effect of allergic reaction.
(16) rhizoma cyperi：Soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, promoting blood circulation and stopping pain.Cure mainly stagnation of QI due to depression of the liver, the distending pain in hypochondrium, breast swelling, hernia
Gas pain, epigastric abdominal fullness pain, belch acid regurgitation, evil of vomitting, fetal irritability.
The Rhizoma Cyperi volatile oil of various dose can substantially cooperate with syngignoscism of the yellow Jackets to mouse, rhizoma cyperi alcohol extracting
Thing has a refrigeration function to rat fever caused by injection saccharomycete, rhizoma cyperi total alkaloid, glucoside, flavonoids and phenolic compound
Aqueous solution also has cardiac stimulant and reducing heart rate effect, and has obvious antihypertensive effect.There is inhibitory action to isolated uterine, make it
Convergent force weakens, Muscle tensility reduces.Rhizoma Cyperi volatile oil has slight estrogenic activity, and in vitro test, Rhizoma Cyperi volatile oil is to golden yellow
Color staphylococcus has inhibitory action, invalid to other bacteriums.Rhizoma Cyperi extract also has inhibitory action to some fungies.
Beneficial effects of the present invention：
(1) Chinese medicine composition of the present invention be effectively combined honeysuckle, the bark of ash, three taste core medicinal material of dandelion and
13 taste such as Fructus Forsythiae, Ligusticum wallichii, seed of cowherb aid in medicinal material the effect of, and use matched preparation method, realize antibacterial anti-inflammatory,
It is newborn under clearing heat and detoxicating, mass dissipating and swelling eliminating, promoting menstruation, and the drug effect of strengthen immunity is taken into account, effectively increase the healing of mastitis for milk cows
Rate, reduces the incidence of mastitis for milk cows, improves the output of milk, reduces the economic loss of raiser, to promoting cattle-raising health
Development has great importance；
(2) Chinese medicine composition materials of the present invention are extensive, of low cost, easy to use and safe and effective, have
The effect of antibacterial anti-inflammatory, clearing heat and detoxicating, strengthen immunity, can not only reduce the probability of mastitis for milk cows infection, can also carry
The disease resistance of high health ox；
(3) Chinese medicine composition of the present invention is greatly improved the cure rate of mastitis for milk cows, after also can ensure that healing
The output of milk of ox, efficiently solve ineffective, medicament residue in existing treatment method, be easy to recur, cure after the output of milk very
The problems such as hardly possible is recovered；
(4) Chinese medicine composition of the present invention avoids the use of antibiotic, using diagnosis and treatment based on an overall analysis of the illness and the patient's condition, the side to treat both principal and secondary aspect of disease
Method, suppresses or kills the pathogen of mammitis directly or by the immunity for improving body indirectly.
(5) present invention uses fig and pure water solid-liquid ratio as 1: 1.6-1.9, and effectively aga can be carried out
Maximized extraction, and after carrying out ultrasonication to fig using this solid-liquid ratio, fiber and decocts medicament and is combined
Use, the treatment to follow-up mammitis is acted on good dredging.
(6) acetobacter and glucose oxidation and bacillus are added in ferment at constant temperature, and under daily 25 seconds to bacterium solution into
Row microwave treatment, can improve the fermentation rate of strain, and under microwave treatment, strain can more effectively decompose fig,
The additive amount of follow-up enzyme is reduced, it is cost-effective.
(7) weight ratio of fig and complex enzyme is 100: 0.5-2, and complex enzyme uses ficin, Papain
Enzyme, glucoamylase mixing, can effectively remove deproteinized and carbohydrate.
Embodiment
With reference to embodiment, the present invention is described further.
Embodiment 1
A kind of Chinese medicine composition for treating mastitis for milk cows, it is characterised in that said composition is matched somebody with somebody by following raw materials and consumption
System：5 parts of pangolin, 20 parts of honeysuckle, 20 parts of the bark of ash, 20 parts of dandelion, 10 parts of semiaquilegia adoxoides, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of Ligusticum wallichii, Cortex Magnoliae Officinalis
10 parts, 20 parts of Fructus Forsythiae, 10 parts of luffa, 10 parts of Chinese violet, 10 parts of radix astragali, 10 parts of Angelica sinensis, 10 parts of the seed of cowherb, radix glycyrrhizae 10
Part, 10 parts of rhizoma cyperi, 30 parts of fig.
A kind of Chinese medicine composition preparation method for treating mastitis for milk cows, comprises the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water
Solid-liquid ratio is 1: 1.6, carries out ultrasonication, and the condition of ultrasonication is 20kHz, power 200W, time 0.5h, so
Afterwards as fermenting under the conditions of 25 DEG C, during fermentation, add acetobacter and glucose oxidation and bacillus, acetobacter and grape are glycoxidative
Bacillus additive amount is the 0.5% and 0.3% of fig weight respectively, microwave treatment in fermentation process, the microwave treatment
Condition is 1.05kHz, and power 500W, the time is daily 25s, ferments 1-3 days and filters, obtains fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds the weight of complex enzyme and 2 parts of water, the fig and complex enzyme
Amount is than being 100: 0.5；The complex enzyme is ficin, papain, the mixture of glucoamylase, no flower
Fruit protease, papain, the mass ratio of glucoamylase is 2: 1: 5, and enzymolysis, isolates supernatant and solid slag；Point
Other that supernatant and solid slag are dried, mixing, obtains fiber；
(3) medicament is prepared：Weigh except other raw materials of fig mix；2500 parts of room temperature are added into the medicament mixed
Water, soaks 30 minutes；After boiling by intense fire, continue to decoct 40 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；To described
2000 parts of normal-temperature waters are added in the dregs of a decoction, using being cooked by slow fire 40 minutes, filters, obtains secondary liquid；By a liquid and secondary medicine
Liquid merges, and adds the fiber that step 2 obtains, that is, obtains the Chinese medicine composition of one treatment mastitis for milk cows.
Embodiment 2：
A kind of Chinese medicine composition for treating mastitis for milk cows, it is characterised in that said composition is matched somebody with somebody by following raw materials and consumption
System：10 parts of pangolin, 30 parts of honeysuckle, 30 parts of the bark of ash, 30 parts of dandelion, 20 parts of semiaquilegia adoxoides, 20 parts of Radix Salviae Miltiorrhizae, 20 parts of Ligusticum wallichii, Cortex Magnoliae Officinalis
20 parts, 30 parts of Fructus Forsythiae, 20 parts of luffa, 20 parts of Chinese violet, 20 parts of radix astragali, 20 parts of Angelica sinensis, 20 parts of the seed of cowherb, radix glycyrrhizae 20
Part, 20 parts of rhizoma cyperi, 60 parts of fig.
A kind of Chinese medicine composition preparation method for treating mastitis for milk cows, comprises the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water
Solid-liquid ratio is 1: 1.9, carries out ultrasonication, and the condition of ultrasonication is 25kHz, power 200-280W, time 1h,
Then as fermenting under the conditions of 35 DEG C, during fermentation, acetobacter and glucose oxidation and bacillus, acetobacter and grape glycosyloxy are added
It is the 0.5% and 0.3% of fig weight respectively to change bacillus additive amount, microwave treatment in fermentation process, the microwave treatment
Condition be 1.05kHz, power 500W, the time is daily 25s, fermentation 1-3 days filtering, obtain fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds the weight of complex enzyme and 2 parts of water, the fig and complex enzyme
Amount is than being 100: 2；The complex enzyme is ficin, papain, the mixture of glucoamylase, fig
Protease, papain, the mass ratio of glucoamylase is 2: 1: 5, and enzymolysis, isolates supernatant and solid slag；Respectively
Supernatant and solid slag are dried, mixes, obtains fiber；
(3) medicament is prepared：Weigh except other raw materials of fig mix；3000 parts of room temperature are added into the medicament mixed
Water, soaks 30 minutes；After boiling by intense fire, continue to decoct 50 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；To described
2500 parts of normal-temperature waters are added in the dregs of a decoction, using being cooked by slow fire 45 minutes, filters, obtains secondary liquid；By a liquid and secondary medicine
Liquid merges, and adds the fiber that step 2 obtains, that is, obtains the Chinese medicine composition of one treatment mastitis for milk cows.
Embodiment 3：
A kind of Chinese medicine composition for treating mastitis for milk cows, said composition are prepared by following raw materials and consumption：Pangolin 7
Part, 22 parts of honeysuckle, 21 parts of the bark of ash, 23 parts of dandelion, 12 parts of semiaquilegia adoxoides, 13 parts of Radix Salviae Miltiorrhizae, 12 parts of Ligusticum wallichii, 13 parts of Cortex Magnoliae Officinalis, Fructus Forsythiae 22
Part, 12 parts of luffa, 11 parts of Chinese violet, 12 parts of radix astragali, 12 parts of Angelica sinensis, 11 parts of the seed of cowherb, 12 parts of radix glycyrrhizae, rhizoma cyperi 13
Part, 50 parts of fig.
A kind of Chinese medicine composition preparation method for treating mastitis for milk cows, comprises the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water
Solid-liquid ratio is 1: 1.8, carries out ultrasonication, and the condition of ultrasonication is 25kHz, power 280W, time 0.5h, so
Afterwards as fermenting under the conditions of 30 DEG C, during fermentation, add acetobacter and glucose oxidation and bacillus, acetobacter and grape are glycoxidative
Bacillus additive amount is the 0.5% and 0.3% of fig weight respectively, microwave treatment in fermentation process, the microwave treatment
Condition is 1.05kHz, and power 500W, the time is daily 25s, ferments 1-3 days and filters, obtains fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds the weight of complex enzyme and 2 parts of water, the fig and complex enzyme
Amount is than being 100: 1；The complex enzyme is ficin, papain, the mixture of glucoamylase, fig
Protease, papain, the mass ratio of glucoamylase is 2: 1: 5, and enzymolysis, isolates supernatant and solid slag；Respectively
Supernatant and solid slag are dried, mixes, obtains fiber；
(3) medicament is prepared：Weigh except other raw materials of fig mix；3000 parts of room temperature are added into the medicament mixed
Water, soaks 30 minutes；After boiling by intense fire, continue to decoct 50 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；To described
2000 parts of normal-temperature waters are added in the dregs of a decoction, using being cooked by slow fire 45 minutes, filters, obtains secondary liquid；By a liquid and secondary medicine
Liquid merges, and adds the fiber that step 2 obtains, that is, obtains the Chinese medicine composition of one treatment mastitis for milk cows.
Embodiment 4
A kind of Chinese medicine composition for treating mastitis for milk cows, said composition are prepared by following raw materials and consumption：Pangolin 9
Part, 27 parts of honeysuckle, 27 parts of the bark of ash, 26 parts of dandelion, 18 parts of semiaquilegia adoxoides, 15 parts of Radix Salviae Miltiorrhizae, 17 parts of Ligusticum wallichii, 19 parts of Cortex Magnoliae Officinalis, Fructus Forsythiae 26
Part, 18 parts of luffa, 19 parts of Chinese violet, 18 parts of radix astragali, 18 parts of Angelica sinensis, 18 parts of the seed of cowherb, 18 parts of radix glycyrrhizae, rhizoma cyperi 18
Part, 58 parts of fig.
A kind of Chinese medicine composition preparation method for treating mastitis for milk cows, comprises the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water
Solid-liquid ratio is 1: 1.8, carries out ultrasonication, and the condition of ultrasonication is 20kHz, power 250W, time 1h, then
As for fermenting under the conditions of 25 DEG C, during fermentation, acetobacter and glucose oxidation and bacillus, acetobacter and the glycoxidative bar of grape are added
Bacterium additive amount is the 0.5% and 0.3% of fig weight respectively, microwave treatment in fermentation process, the bar of the microwave treatment
Part is 1.05kHz, and power 500W, the time is daily 25s, ferments 1-3 days and filters, obtains fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds the weight of complex enzyme and 2 parts of water, the fig and complex enzyme
Amount is than being 100: 1.5；The complex enzyme is ficin, papain, the mixture of glucoamylase, no flower
Fruit protease, papain, the mass ratio of glucoamylase is 2: 1: 5, and enzymolysis, isolates supernatant and solid slag；Point
Other that supernatant and solid slag are dried, mixing, obtains fiber；
(3) medicament is prepared：Weigh except other raw materials of fig mix；3000 parts of room temperature are added into the medicament mixed
Water, soaks 30 minutes；After boiling by intense fire, continue to decoct 50 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；To described
2000 parts of normal-temperature waters are added in the dregs of a decoction, using being cooked by slow fire 45 minutes, filters, obtains secondary liquid；By a liquid and secondary medicine
Liquid merges, and adds the fiber that step 2 obtains, that is, obtains the Chinese medicine composition of one treatment mastitis for milk cows.
Embodiment 5
A kind of Chinese medicine composition for treating mastitis for milk cows, said composition are prepared by following raw materials and consumption：Pangolin 8
Part, 25 parts of honeysuckle, 24 parts of the bark of ash, 25 parts of dandelion, 17 parts of semiaquilegia adoxoides, 14 parts of Radix Salviae Miltiorrhizae, 15 parts of Ligusticum wallichii, 18 parts of Cortex Magnoliae Officinalis, Fructus Forsythiae 25
Part, 13 parts of luffa, 15 parts of Chinese violet, 17 parts of radix astragali, 15 parts of Angelica sinensis, 15 parts of the seed of cowherb, 17 parts of radix glycyrrhizae, rhizoma cyperi 16
Part, 56 parts of fig.
A kind of Chinese medicine composition preparation method for treating mastitis for milk cows, comprises the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water
Solid-liquid ratio is 1: 1.9, carries out ultrasonication, and the condition of ultrasonication is 20kHz, power 230W, time 0.5h, so
Afterwards as fermenting under the conditions of 30 DEG C, during fermentation, add acetobacter and glucose oxidation and bacillus, acetobacter and grape are glycoxidative
Bacillus additive amount is the 0.5% and 0.3% of fig weight respectively, microwave treatment in fermentation process, the microwave treatment
Condition is 1.05kHz, and power 500W, the time is daily 25s, ferments 1-3 days and filters, obtains fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds the weight of complex enzyme and 2 parts of water, the fig and complex enzyme
Amount is than being 100: 2；The complex enzyme is ficin, papain, the mixture of glucoamylase, fig
Protease, papain, the mass ratio of glucoamylase is 2: 1: 5, and enzymolysis, isolates supernatant and solid slag；Respectively
Supernatant and solid slag are dried, mixes, obtains fiber；
(3) medicament is prepared：Weigh except other raw materials of fig mix；3000 parts of room temperature are added into the medicament mixed
Water, soaks 30 minutes；After boiling by intense fire, continue to decoct 40 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；To described
2000 parts of normal-temperature waters are added in the dregs of a decoction, using being cooked by slow fire 40 minutes, filters, obtains secondary liquid；By a liquid and secondary medicine
Liquid merges, and adds the fiber that step 2 obtains, that is, obtains the Chinese medicine composition of one treatment mastitis for milk cows.
Following table is to be counted using the traditional Chinese medicine composition for treating mastitis for milk cows result of the present invention
| Treat case | Treat number | Cure number | It is dead to wash in a pan number | Cure rate % |
| 1 | 100 | 98 | 2 | 98 |
| 2 | 100 | 99 | 1 | 99 |
| 3 | 100 | 98 | 2 | 98 |
| 4 | 100 | 98 | 2 | 98 |
| 5 | 100 | 98 | 2 | 98 |
The present invention has good therapeutic effect to mastitis for milk cows as can be seen from the table.
The above is only the preferred embodiment of the present invention, it should be pointed out that：For the ordinary skill people of the art
For member, without departing from the principle of the present invention, some improvement can also be made, these improvement should be regarded as the guarantor of the present invention
Protect scope.
Claims (8)
1. a kind of Chinese medicine composition for treating mastitis for milk cows, it is characterised in that said composition is prepared by following raw materials and consumption：
5-10 parts of pangolin, 20-30 parts of honeysuckle, 20-30 parts of the bark of ash, 20-30 parts of dandelion, 10-20 parts of semiaquilegia adoxoides, 10-20 parts of Radix Salviae Miltiorrhizae,
10-20 parts of Ligusticum wallichii, 10-20 parts of Cortex Magnoliae Officinalis, 20-30 parts of Fructus Forsythiae, 10-20 parts of luffa, 10-20 parts of Chinese violet, radix astragali 10-20
Part, 10-20 parts of Angelica sinensis, 10-20 parts of the seed of cowherb, 10-20 parts of radix glycyrrhizae, 10-20 parts of rhizoma cyperi, 30-60 parts of fig.
A kind of 2. Chinese medicine composition for treating mastitis for milk cows as claimed in claim 1, it is characterised in that said composition by with
Lower raw materials and consumption is prepared：7-9 parts of pangolin, 22-27 parts of honeysuckle, 21-27 parts of the bark of ash, 23-26 parts of dandelion, semiaquilegia adoxoides 12-
18 parts, 13-15 parts of Radix Salviae Miltiorrhizae, 12-17 parts of Ligusticum wallichii, 13-19 parts of Cortex Magnoliae Officinalis, 22-26 parts of Fructus Forsythiae, 12-18 parts of luffa, Chinese violet
11-19 parts, 12-18 parts of radix astragali, 12-18 parts of Angelica sinensis, 11-18 parts of the seed of cowherb, 12-18 parts of radix glycyrrhizae, 13-18 parts of rhizoma cyperi, no flower
50-58 parts of fruit.
A kind of 3. Chinese medicine composition for treating mastitis for milk cows as claimed in claim 1, it is characterised in that said composition by with
Lower raw materials and consumption is prepared：8 parts of pangolin, 25 parts of honeysuckle, 24 parts of the bark of ash, 25 parts of dandelion, 17 parts of semiaquilegia adoxoides, 14 parts of Radix Salviae Miltiorrhizae,
15 parts of Ligusticum wallichii, 18 parts of Cortex Magnoliae Officinalis, 25 parts of Fructus Forsythiae, 13 parts of luffa, 15 parts of Chinese violet, 17 parts of radix astragali, 15 parts of Angelica sinensis, the seed of cowherb
15 parts, 17 parts of radix glycyrrhizae, 16 parts of rhizoma cyperi, 56 parts of fig.
4. a kind of Chinese medicine composition preparation method for the treatment of mastitis for milk cows as described in claim 1-3 is any, its feature exist
In comprising the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water feed liquid
Than for 1: 1.6-1.9, carrying out ultrasonication, then as fermenting under the conditions of 25-35 DEG C, microwave treatment in fermentation process, hair
Ferment filters for 1-3 days, obtains fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds complex enzyme and 2 parts of water, digested, isolate supernatant and solid slag；Point
Other that supernatant and solid slag are dried, mixing, obtains fiber；
(3) medicament is prepared：Weigh except other raw materials of fig mix；2500~3000 parts are added into the medicament mixed often
Warm water, soaks 30 minutes；After boiling by intense fire, continue to decoct 40~50 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；
2000~2500 parts of normal-temperature waters are added into the dregs of a decoction, using being cooked by slow fire 40~45 minutes, filters, obtains secondary liquid；Will
Liquid and secondary liquid merge, and add the fiber that step 2 obtains, that is, obtain the Chinese medicine group of one treatment mastitis for milk cows
Compound.
5. the Chinese medicine composition preparation method for the treatment of mastitis for milk cows according to claim 4, it is characterised in that：Described
The condition of ultrasonication is 20-25kHz, power 200-280W, time 0.5-1h.
6. the Chinese medicine composition preparation method for the treatment of mastitis for milk cows according to claim 4, it is characterised in that：In step
(1) during fermentation described in, acetobacter and glucose oxidation and bacillus, acetobacter and glucose oxidation and bacillus additive amount point are added
It is not the 0.5% and 0.3% of fig weight.
7. the Chinese medicine composition preparation method for the treatment of mastitis for milk cows according to claim 4, it is characterised in that：Described
The condition of microwave treatment is 1.05kHz, and power 500W, the time is daily 25s.
8. the Chinese medicine composition preparation method for the treatment of mastitis for milk cows according to claim 4, it is characterised in that：Described
The weight ratio of fig and complex enzyme is 100: 0.5-2；The complex enzyme is ficin, papain, grape
The mixture of saccharogenic amylase, ficin, papain, the mass ratio of glucoamylase is 2: 1: 5.
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| CN113117029A (en) * | 2021-04-22 | 2021-07-16 | 章国忠 | Traditional Chinese medicine composition for reducing somatic cell count in milk and preparation method thereof |
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