CN107951972A - Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof - Google Patents
Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof Download PDFInfo
- Publication number
- CN107951972A CN107951972A CN201711210247.6A CN201711210247A CN107951972A CN 107951972 A CN107951972 A CN 107951972A CN 201711210247 A CN201711210247 A CN 201711210247A CN 107951972 A CN107951972 A CN 107951972A
- Authority
- CN
- China
- Prior art keywords
- parts
- medicine composition
- thing
- chinese traditional
- milk cows
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing, said composition is made of radix scutellariae, Radix Salviae Miltiorrhizae, Fructus Forsythiae, safflower, Angelica sinensis, garden burnet, dandelion, giant knotweed, frankincense, myrrh, honeysuckle, radix glycyrrhizae, oldenlandia diffusa, rhizoma cyperi, and above-mentioned raw materials are soaked, are boiled, cream processed forms；This composition materials are extensive, of low cost, easy to use, safe effectively, there is invigorate blood circulation, dissipating blood stasis and reducing the stagnation, antibacterial anti-inflammatory, the newborn network of dredging, belong to non-specific antimicrobial, not only there is directly antibacterial, sterilization, not the advantages of not producing drug resistance, and have the effect of resistance and immunity for strengthening body.
Description
Technical field
The invention belongs to animal medicinal composition, more particularly to be that one kind treats mastitis for milk cows composition and its preparation side
Method.
Background technology
Mastitis for milk cows is the important diseases for endangering milk cattle cultivating, and huge harm and economic damage are caused to Cow product
Lose.Mastitis for milk cows refers to the inflammation of the cow breast as caused by the various causes of disease, in economic loss caused by mammitis, due to
The output of milk accounts for the 70% of loss caused by reducing, and makes what milk cow did sth. in advance to eliminate to account for 14% due to diseased, discarded milk accounts for 10%.
In a cows, most mammitises are recessive types, therefore cause mainly recessive mastitis, its loss of economic loss to account for
The 10%~11% of the annual total productive capacity of every lactating cow.Microbiological factor, environmental factor, Milking Methods And Techniques etc. can draw
Mastitis for milk cows is played, such as the infection of Streptococcusagalactiae and staphylococcus aureus, milker do not sterilize, milking person's misoperation
Deng.In addition, for high yield cow, though the daily ration of high-energy, high protein is conducive to protect and improve the output of milk, also increase at the same time
The load of breast, makes the resistance of body reduce, so as to trigger mammitis.
The infected cattle clinical manifestation for suffering from mastitis for milk cows changes for milk color, and milk is thin, wherein having floccule, coagulating
Block and a large amount of leucocytes or into serum sample, the acute swelling of ill breast district, rubefaction, the fever of palpation breast, swelling, have lump,
Pain sensitivity, for acute generalised mammitis, if effectively treatment not in time, can jeopardize affected animal life.
It is many to treat mastitis for milk cows method, has been summed up：1. whole body application antibiosis extract for treating eliminates the cause of disease of infection
Body, such as penicillin, streptomysin, erythromycin, sulfa drugs；2. intramammary injection antibiotic etc..These methods exist certain
Therapeutic effect, but there is also shortcomings, for example, long-term, high-dose causes antibody-resistant bacterium to increase using antibiotic, tetracycline,
The application of the antibiotic such as erythromycin can influence Immune Function, cause organism infection complicated symptoms, antibiotic is in breast
Residual in juice can directly influence the health of people, prevent medicine from being combined with protein to reduce drug effect, medicine after intramammary injection
Thing will have a longer half-life period in vivo, abandon newborn phase extension after causing medication, cause economic loss.And Chinese herbal treatment breast
Inflammation, short treating period is quick, economical and practical, and Chinese herbal medicine not only has antibacterial, antivirus action, also has the work for adjusting body function
With.Therefore it is trend of the times to apply Chinese medicine or explore other effective treatment methods having no toxic side effect.
The content of the invention
The purpose of the present invention aiming at above-mentioned treatment mastitis for milk cows there are the problem of, research and development one kind treat milk cow
Apply medicinal lotion or ointment outside the Chinese traditional medicine composition of mammitis thing and preparation method thereof, reach and increase substantially mastitis for milk cows cure rate, and cost
Purpose that is cheap, having no toxic side effect；The invention also discloses the preparation method of the Chinese medicine composition.
The technical scheme is that：Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing, said composition by with
Lower raw materials and consumption is prepared：10-20 parts of radix scutellariae, 10-20 parts of Radix Salviae Miltiorrhizae, 20-30 parts of Fructus Forsythiae, 10-20 parts of safflower, 10-20 parts of Angelica sinensis,
10-20 parts of garden burnet, 20-30 parts of dandelion, 10-20 parts of giant knotweed, 10-20 parts of frankincense, 10-20 parts of myrrh, 20-30 parts of honeysuckle,
10-20 parts of radix glycyrrhizae, 10-20 parts of oldenlandia diffusa, 10-20 parts of rhizoma cyperi, 30-60 parts of fig.
Preferably, apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing, said composition is by following raw materials and consumption
Prepare：12-18 parts of radix scutellariae, 13-17 parts of Radix Salviae Miltiorrhizae, 21-28 parts of Fructus Forsythiae, 11-16 parts of safflower, 13-17 parts of Angelica sinensis, 12-19 parts of garden burnet,
21-27 parts of dandelion, 13-16 parts of giant knotweed, 11-17 parts of frankincense, 13-16 parts of myrrh, 22-26 parts of honeysuckle, 11-17 parts of radix glycyrrhizae,
13-19 parts of oldenlandia diffusa, 12-19 parts of rhizoma cyperi, 33-56 parts of fig.
Preferably, apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing, it is characterised in that said composition is by following
Raw materials and consumption is prepared：14 parts of radix scutellariae, 15 parts of Radix Salviae Miltiorrhizae, 27 parts of Fructus Forsythiae, 13 parts of safflower, 16 parts of Angelica sinensis, 18 parts of garden burnet, dandelion 26
Part, 15 parts of giant knotweed, 16 parts of frankincense, 14 parts of myrrh, 25 parts of honeysuckle, 16 parts of radix glycyrrhizae, 18 parts of oldenlandia diffusa, 17 parts of rhizoma cyperi, nothing
50 parts of flowers and fruits.
Present invention also offers a kind of preparation method for thing of applying medicinal lotion or ointment outside Chinese traditional medicine composition for treating mastitis for milk cows, including it is following
Step：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water
Solid-liquid ratio is 1: 1.6-1.9, carries out ultrasonication, then as fermenting under the conditions of 25-35 DEG C, in fermentation process at microwave
Reason, ferments 1-3 days and filters, obtain fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds complex enzyme and 2 parts of water, digested, isolate supernatant and solid
Slag；Supernatant and solid slag are dried respectively, mixes, obtains fiber；
(3) other raw materials mixing except fig is weighed；2500~3000 parts of normal-temperature waters are added into the medicament mixed,
Immersion 30 minutes；After boiling by intense fire, continue to decoct 40~50 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；To described
2000~2500 parts of normal-temperature waters are added in the dregs of a decoction, using being cooked by slow fire 40~45 minutes, filters, obtains secondary liquid；By a medicine
Liquid and secondary liquid merge；
(4) medicament that step (3) has boiled is purified with ethanol water bath, the triethanolamine of 0.3mL is added after sterilizing, is made
Aqueous solution, adds 3.5g glycerin monostearates and 3g vaseline in aqueous, and 80 DEG C of stirring in water bath, are made paste, then
The fiber that the azone of addition paste 5%, 10% 1,2-PD, 30% dimethyl sulfoxide (DMSO), step (2) are prepared,
Condensation is continuously stirring to, liniment is made, that is, obtains the Chinese traditional medicine composition liniment of one treatment mastitis for milk cows.
Preferably, in the ferment at constant temperature described in step (1), acetobacter and glucose oxidation and bacillus, acetic acid bar are added
Bacterium and glucose oxidation and bacillus additive amount are the 0.5% and 0.3% of fig weight respectively.
Preferably, the condition of the ultrasonication is 20-25kHz, power 200-280W, time 0.5-1h.
Preferably, the condition of the microwave treatment is 1.05kHz, power 500W, time 25s.
Preferably, the weight ratio of the complex enzyme and fig is 100: 1-2；The complex enzyme is Papain
Enzyme, the mixture of glucoamylase, papain, the mass ratio of glucoamylase is 1: 4.
Core drug in the Chinese medicine composition for the treatment of mastitis for milk cows of the present invention includes Fructus Forsythiae, dandelion, gold
Honeysuckle flower：(1) Fructus Forsythiae is clearing heat and detoxicating, antibacterial anti-inflammatory, antagonism and suppresses the pathogenic microorganism for causing mastitis for milk cows, and the carbuncle that can also disappear
Burst hard, have obvious effect for acute mastitis swelling and pain, the dredging of postpartum thymus gland.(2) dandelion has stronger bacteriostasis, and can exactor
The immune function of body, can act synergistically with Fructus Forsythiae.(3) clearing heat and detoxicating, the dispelling wind and heat from the body of honeysuckle energy, while also resist with wide spectrum
Bacterium acts on, and also has inhibitory action to the multiple pathogenic microorganisms for causing mastitis for milk cows.
Remove above-mentioned core drug, the other medicines in composition, as the baicalein in radix scutellariae, scutelloside can suppress anxious
Property inflammatory reaction, suppress inflammatory seep swelling, while penetrating amount increase that can be to capillary together with safflower has significantly
Inhibitory action.Cryptotanshinone, the dihydrotanshinone contained in red sage formulation, to staphylococcus, Escherichia coli, denaturation bacillus have compared with
Strong inhibitory action.Angelica sinensis, garden burnet and giant knotweed can play the effect that wound, Apocenosis pain relieving are held back in detumescence when controlling ulcer, and garden burnet is also
There is good anastalsis.Myrrh, frankincense, oldenlandia diffusa and rhizoma cyperi can cooperate with performance antibacterial when treating mastitis for milk cows
Anti-inflammatory, detumescence ding-tong, the effect for dissipating blood stasis eliminatings, while can also make to causing the pathogenic microorganism of mastitis for milk cows to play suppression
With.Radix glycyrrhizae also plays flavored action in addition to can be with anti-inflammatory, enhancing immunity of organisms to Chinese medicine composition.
The pharmacological action of various Chinese medicines in the Chinese medicine composition for the treatment of mastitis for milk cows of the present invention：
(1) radix scutellariae：Heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, tocolysis, blood pressure lowering.It is damp and hot for damp-warm syndrome, heat temperature chest tightness and emesis
Feeling of fullness, rush down dysentery, jaundice, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, fetal irritability.Cure mainly the warm heat disease, infection of the upper respiratory tract, wet
The diseases such as hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, carbuncle swells furuncle sore.
The clinical practice antibacterial of radix scutellariae is not worse than the coptis, and does not develop immunity to drugs.To a variety of gram positive bacterias, Ge Lanyin
Property bacterium, pathogenic dermatophyte have inhibitory action.Baicalein, scutelloside can suppress acute inflammatory reaction, suppress inflammatory seep
Swelling, capillary permeability increase；Adjust immune function, antipyretic, calm, liver protection, cholagogic etc..The antibiotic such as penicillin are produced
Raw drug-fast staphylococcus aureus, it is still very sensitive to radix scutellariae.
(2) Radix Salviae Miltiorrhizae：Promoting blood circulation, inducing meastruation to relieve menalgia, cool blood to disappear carbuncle.Treat arthralgia pain due to rheumatism, uterine hemorrhage, haematemesis, mastitis,
Sore swell and ache curative.
Radix Salviae Miltiorrhizae energy coronary artery dilator, increases coronary flow, improves myocardial ischemia, infraction and cardiac function, adjusts the rhythm of the heart,
And peripheral blood vessel can be expanded, improve microcirculation；Shorten the convalescence of red blood cell and hemochrome, increase Reticulocyte, can promote
The reparation of tissue；Body's hypoxia tolerance, and anticoagulation can also be improved, promotes fibrinolytic, suppresses platelet aggregation, suppresses thrombus
The effect of formation, and the immune function of body can be strengthened.
(3) Fructus Forsythiae：Heat-clearing, removing toxic substances, dissipating bind, detumescence.Control warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching closes,
Control acute mastitis, newborn core.
Fructus Forsythiae has broad-spectrum antibacterial action, has very strong inhibitory action to staphylococcus aureus, Hayes shigella dysenteriae, to it
His pathogenic bacteria, influenza virus, fungi have certain inhibitory action.There is anti-inflammatory effect.Oleanolic acid contained by this product has cardiac stimulant, diuresis
And hypotensive activity, citrin can reduce vasopermeability and brittleness, prevent haemolysis.Decoction have anti-vomiting effect, dispelling wind and heat from the body,
Anti-liver injury acts on.
(4) safflower：Invigorate blood circulation, removing blood stasis and analgesics.For Amenorrhea, dysmenorrhoea, lochia, abdominal mass lump in the abdomen, traumatic injury, sore
Ulcer swell and ache, and blood stasis and swelling pain caused by traumatic injury, carbuncle swells and haematemesis and have the stagnant person of the stasis of blood.
Crude extract from carthamus tinctorius L. with water and safflower water soluble mixt-carthamin yellow have increase coronary blood flow and myocardial nutrition
The effect of blood flow, while myocardial ischemia can be improved；It can influence internal and external blood coagulation system at the same time, suppress thrombus shape
Into.Penetrating amount increase of the carthamin yellow to rat skin capillary caused by histamine has obvious inhibitory action.It is in addition, red
Flower polysaccharide can promote to drench cell transformation, be a kind of new immunomodulator.
(5) Angelica sinensis：Replenishing and activating blood, menstruction regulating and pain relieving, moisturize laxation, cure mainly the deficiency of blood it is all card, abdominal mass knot gather, uterine bleeding, cold of insufficiency type abdomen
Bitterly, Impotence numbness, numbness, intestines are dry and shit is difficult, weight, ulcer sores, injury from falling down after dysentery characterized by blood in the stool.Being capable of Apocenosis pain relieving when controlling ulcer.
Chinese angelica volatile oil has direct repression, envoy to the isolated uterine of the animals such as rabbit, cavy, mouse, rat, dog
Rule property, which is shunk, to be tapered into disappearance, in relaxation state；And resist pituitrin, histamine, adrenaline and acetylcholine etc.
Caused uterine contractile.Contained volatile oil can be such that myocardial contraction frequency is substantially suppressed in Angelica sinensis decoction or root and leaf, it contains
There are many kinds of substance such as volatile oil, organic acid, amino acid, vitamin, trace element, body hematopoiesis function can be remarkably promoted, raise
Red blood cell, leucocyte and content of hemoglobin；Suppress platelet aggregation, antithrombotic, adjusts blood fat；Resist myocardial ischemia, the rhythm of the heart loses
Often, blood vessel is expanded, is reduced blood pressure；Adjust uterine smooth muscle.Also strengthen immune, anti-inflammatory, liver protection, anti-oxidant and removing free radical
Deng effect, can there is antibacterial action to external dysentery, typhoid fever, paratyphoid, Escherichia coli, comma bacillus etc..Angelica sinensis tune blood is
Dam key medicine, controls and is rushed on pregnant woman's postpartum extravesated blood, qi and blood can be made respectively to have returned.
(6) garden burnet：Cooling blood and hemostasis, clearing heat and detoxicating, ulcerative carbuncle swelling and pain, healing up sore and subduing swelling.For having blood in stool, hemorrhoid blood, bloody flux, uterine bleeding,
Scald, carbuncle sore tumefacting virus.
Garden burnet contains tannin, has astriction, energy antidiarrheal and hemostasis, can reduce exudation reduction, infection rate；Garden burnet
100% decocting liquid is to typhoid bacillus, diplococcus meningitidis, beta hemolytic streptococcus, staphylococcus aureus, the double balls of pneumonia
Bacterium, Escherichia coli, hay bacillus, typhoid bacillus, paratyphosum Bacterium, Pseudomonas aeruginosa, comma bacillus have different degrees of suppression
Effect.Radix Sangusorbae, water extract, charred RADIX SANGUISORBAE, Rhizoma sanguisorbae preparation have blood effect processed, this effect is mainly related with tannin；Garden burnet decoction
Low concentration can strengthen isolated frog heart shrink, frequency deceleration, cardiac output increase.
(7) dandelion：Clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia.Treat furuncle swelling toxin, acute mastitis, scrofula, hot eyes, pharynx
Bitterly, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea.
This product decoction or preserved material, have staphylococcus aureus, hemolytic streptococcus and micrococcus catarrhalis stronger suppression to make
With also having to Diplococcus pneumopniae, diplococcus meningitidis, corynebacterium diphtheriae, shigella flexneri, Pseudomonas aeruginosa and Leptospira etc.
Certain inhibitory action.Still there are cholagogic, liver protection, antiendotoxin and diuresis.Dandelion aerial part water extract can activate
Macrophage, there is antitumor action.The immune function of energy excitating organism.
(8) giant knotweed：It is clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, scattered stasis pain, relieving cough and reducing sputum.It is wet for joint pain
Hot jaundice, Amenorrhea , wei lumps in the abdomen, coughing with a lot of sputum, scald, injury from falling down, carbuncle sore tumefacting virus.
Giant knotweed can increase myocardial alimentary blood flow, and giant knotweed, small hypericum japonicum decoction can substantially reduce serum liver red pigment amount and drop
The effect of low serum glutamic pyruvic transminase vigor；7.5% decocting liquid of giant knotweed can shrink guinea pig trachea caused by antihistamine, have certain
Antiasthmatic effect；Also there can be convergence to scald wound, prevent infection and antiinflammation.A kind of in addition, flavones contained in giant knotweed
Class material has inhibitory action to staphylococcus aureus, staphylococcus albus, proteus.
(9) frankincense：Regulating qi and activating blood, analgesic therapy, chases after poison.Control qi and blood stagnation, trusted subordinate's pain, ulcerative carbuncle pyogenic infections, traumatic injury, postpartum
Hemostasis shouting pain.
Its component mainly has resin, natural gum and volatile oil, polynuclear leucocyte can be promoted to increase, with the dead blood cell of phagocytosis and
Cell, improves metabolism, so that antiinflammation is played, while also astriction, wound healing can be promoted；Second in volatile oil
Sour n-octyl has analgesic activity；Damage of the medicine to gastric mucosa can also be reduced；Diuresis promoting menstruation effect is obvious.There is stronger analgesia
And bacteriostasis, and can effectively kill trichomonad.
(10) myrrh：Promoting blood circulation and stopping pain, detumescence and promoting granulation, antibacterial anti-inflammatory, dissipate blood stasis eliminatings, cure mainly chest and abdomen stasis caused pain, Amenorrhea, Disorder lumps in the abdomen,
Traumatic injury, carbuncle swells sore, acute appendicitis.
The flooding agent (1: 2) of myrrh is a variety of to trichophyton, Trichophyton concentricum, oidium schoenleinii etc. in vitro
Pathomycete has different degrees of inhibitory action, and the antibacterial action of myrrh may be related with the phenol of song containing cloves；With other oil-containing trees
The material of fat is similar, and myrrh has some local irritant effects (generally with tincture), available in mouth wass, it can also be used to stomach and intestine
With excited enterocinesia when powerless.
(11) honeysuckle：It is clearing heat and detoxicating, dispelling wind and heat from the body.Treat carbuncle swells and treat sore, larynx numbness, erysipelas, toxic-heat and blood stasis, wind-heat sense
Emit, warm disease heating.
Honeysuckle is to various pathogens such as staphylococcus aureus, hemolytic streptococcus, Escherichia coli, shigella dysenteriae, suddenly
Random vibrios, typhoid bacillus, paratyphosum Bacterium etc. have certain inhibitory action, to pneumococcus, diplococcus meningitidis, green pus bar
Bacterium, tubercle bacillus are also effective.Honeysuckle also has obvious anti-inflammatory and refrigeration function, and honeysuckle flower water and steeping in wine liquid are to tentative swollen
Oncocyte has obvious lethal effect.Booster immunization function acts on, and promotes the phagocytic function of leucocyte.There is antiendotoxin work
With.
(12) radix glycyrrhizae：Invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moistens the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription.
Radix glycyrrhizae life, can purging intense heat and detonicating, relieving spasm to stop pain with cooler；Process and use partial temperature, exterior cold, tonifying middle-Jiao and Qi can be dissipated.Radix glycyrrhizae has class
Like adrenocortical hormones fuction, there is inhibitory action to gastroxia caused by histamine；And there are antiacid and alleviation stomach and intestine
Smooth muscle spasm acts on.Extract of licorice root and enoxolone have obvious antitussive effect, and phlegm-dispelling functions are also more significant；Contained by radix glycyrrhizae
Hypo acid can block Induced by Carcinogen tumour growth.In addition, radix glycyrrhizae is also good at mediation property of medicine, the poison of hundred medicines is solved, and has anti-inflammatory, resist
The effect of allergic reaction.
(13) oldenlandia diffusa：Clearing heat and detoxicating, medicinal powder for relieving pain knot, inducing diuresis to remove edema.For abscess of throat, dyspnea and cough due to lung-heat, heat gonorrhea
Puckery pain, jaundice with damp-heat pathogen, venomous snake bite, the hot carbuncle of sore swells, outstanding kind treatment all kinds inflammation.
(suitable 6 grams per milliliter of crude drug) is to acute lymphoblastic type, granulocyte type, monocyte type and chronic in vitro
The tumour cell of granulocyte type has to be acted on compared with high inhibition, has inhibitory action to staphylococcus aureus and shigella dysenteriae, its anti-inflammatory
Effect, is caused by stimulating reticuloendothelial system hyperplasia and the enhancing factor such as phagocyte vigor.
(14) rhizoma cyperi：Soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, promoting blood circulation and stopping pain.Cure mainly stagnation of QI due to depression of the liver, the distending pain in hypochondrium, breast swelling, hernia
Gas pain, epigastric abdominal fullness pain, belch acid regurgitation, evil of vomitting, fetal irritability.
The Rhizoma Cyperi volatile oil of various dose can substantially cooperate with syngignoscism of the yellow Jackets to mouse, rhizoma cyperi alcohol extracting
Thing has a refrigeration function to rat fever caused by injection saccharomycete, rhizoma cyperi total alkaloid, glucoside, flavonoids and phenolic compound
Aqueous solution also has cardiac stimulant and reducing heart rate effect, and has obvious antihypertensive effect.There is inhibitory action to isolated uterine, make it
Convergent force weakens, Muscle tensility reduces.Rhizoma Cyperi volatile oil has slight estrogenic activity, and in vitro test, Rhizoma Cyperi volatile oil is to golden yellow
Color staphylococcus has inhibitory action, invalid to other bacteriums.Rhizoma Cyperi extract also has inhibitory action to some fungies.
Beneficial effects of the present invention：
(1) Chinese medicine composition of the present invention be effectively combined Fructus Forsythiae, dandelion, three taste core medicinal material of honeysuckle and
Radix scutellariae, Radix Salviae Miltiorrhizae, safflower etc. ten aids in the effect of medicinal material simply, and uses matched preparation method, realizes antibacterial anti-inflammatory, heat-clearing
It is newborn under removing toxic substances, mass dissipating and swelling eliminating, promoting menstruation, and the drug effect of strengthen immunity is taken into account, the cure rate of mastitis for milk cows is effectively increased, is subtracted
The incidence of few mastitis for milk cows, improves the output of milk, reduces the economic loss of raiser, has to promoting cattle-raising to develop in a healthy way
There is important meaning；
(2) Chinese medicine composition materials of the present invention are extensive, of low cost, easy to use and safe and effective, have
The effect of antibacterial anti-inflammatory, clearing heat and detoxicating, strengthen immunity, the preparation process of outer liniment can at utmost retain the effective of medicine
Component, matrix components purity therein is high, quality is good, drug storage amount is big, it is small, safe to stimulate, and can make medicine through outer wiping administration
Affected part is directly acted on after absorption, it is possible to increase the utilization rate of medicine；
(3) Chinese medicine composition of the present invention is greatly improved the cure rate of mastitis for milk cows, after also can ensure that healing
The output of milk of ox, the problem of effectively prevent dairy produce drug residue, the application method of outer liniment is easy to learn, time saving province
Power, it is quick using outer liniment, i.e. it can be seen that obvious mitigation in the short time, anti-inflammatory analgesic, after drug absorption can also and
Newborn effect, can be used alone, can also coordinate oral preparations to use, efficiently solve existing under the antibacterial detumescences of Shi Fahui, promoting menstruation
Medicine is in vivo after metabolism the problem of drug effect reduction in technology, while also saves manpower and materials；
(4) Chinese medicine composition of the present invention avoids the use of antibiotic, using diagnosis and treatment based on an overall analysis of the illness and the patient's condition, the side to treat both principal and secondary aspect of disease
Method, is suppressed or killed the pathogen of mammitis directly or by the immunity for improving body, directly applied using breast outside indirectly
The mode smeared, makes medicine directly act on affected part, rapid-action, drug effect duration length.
(5) present invention uses fig and pure water solid-liquid ratio as 1: 1.6-1.9, and effectively aga can be carried out
Maximized extraction, and after carrying out ultrasonication to fig using this solid-liquid ratio, fiber and decocts medicament and is combined
Use, the treatment of follow-up mammitis is acted on good dredging.
(6) in ferment at constant temperature, acetobacter and glucose oxidation and bacillus are added, and bacterium solution is carried out under daily 25 seconds
Microwave treatment, can improve the fermentation rate of strain, and under microwave treatment, strain can more effectively decompose fig, drop
The additive amount of low follow-up enzyme, it is cost-effective.
(7) weight ratio of fig and complex enzyme is 100: 0.5-2, and complex enzyme uses papain, glucoamylase
Enzyme mixes, and can effectively remove deproteinized and carbohydrate.
Embodiment
With reference to embodiment, the present invention is described further.
Embodiment 1
Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing, it is characterised in that said composition by following raw material and
Dosage is prepared：10 parts of radix scutellariae, 10 parts of Radix Salviae Miltiorrhizae, 20 parts of Fructus Forsythiae, 10 parts of safflower, 10 parts of Angelica sinensis, 10 parts of garden burnet, 20 parts of dandelion, tiger
10 parts of cane, 10 parts of frankincense, 10 parts of myrrh, 20 parts of honeysuckle, 10 parts of radix glycyrrhizae, 10 parts of oldenlandia diffusa, 10 parts of rhizoma cyperi, fig 30
Part.
Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows the preparation method of thing, comprise the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water
Solid-liquid ratio is 1: 1.6, carries out ultrasonication, and the condition of ultrasonication is 20kHz, power 200W, time 0.5h, so
Afterwards as fermenting under the conditions of 25 DEG C, during fermentation, add acetobacter and glucose oxidation and bacillus, acetobacter and grape are glycoxidative
Bacillus additive amount is the 0.5% and 0.3% of fig weight respectively, microwave treatment in fermentation process, the microwave treatment
Condition is 1.05kHz, and power 500W, the time is daily 25s, ferments 1-3 days and filters, obtains fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds the weight of complex enzyme and 2 parts of water, the fig and complex enzyme
Amount is than being 100: 0.5；The complex enzyme is papain, the mixture of glucoamylase, papain, glucose
The mass ratio of amylase is 1: 4, and enzymolysis, isolates supernatant and solid slag；Supernatant and solid slag are dried respectively, mixed
Close, obtain fiber；
(3) medicament is prepared：Weigh except other raw materials of fig mix；2500 parts of room temperature are added into the medicament mixed
Water, soaks 30 minutes；After boiling by intense fire, continue to decoct 40 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；To described
2000 parts of normal-temperature waters are added in the dregs of a decoction, using being cooked by slow fire 40 minutes, filters, obtains secondary liquid；By a liquid and secondary medicine
Liquid merges, and the merging medicament boiled is purified with ethanol water bath, and the triethanolamine of 0.3mL is added after sterilizing, aqueous solution is made,
3.5g glycerin monostearates and 3g vaseline are added in aqueous, and 80 DEG C of stirring in water bath, are made paste, add paste
The fiber that the azone of thing 5%, 10% 1,2-PD, 30% dimethyl sulfoxide (DMSO), step (2) are prepared, continuously stirs
To condensation, liniment is made, that is, obtains the Chinese traditional medicine composition liniment of one treatment mastitis for milk cows.
Embodiment 2：
Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing, it is characterised in that said composition by following raw material and
Dosage is prepared：20 parts of radix scutellariae, 20 parts of Radix Salviae Miltiorrhizae, 30 parts of Fructus Forsythiae, 20 parts of safflower, 20 parts of Angelica sinensis, 20 parts of garden burnet, 30 parts of dandelion, tiger
20 parts of cane, 20 parts of frankincense, 20 parts of myrrh, 30 parts of honeysuckle, 20 parts of radix glycyrrhizae, 20 parts of oldenlandia diffusa, 20 parts of rhizoma cyperi, fig 60
Part.
Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows the preparation method of thing, comprise the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water
Solid-liquid ratio is 1: 1.9, carries out ultrasonication, and the condition of ultrasonication is 25kHz, power 200-280W, time 1h,
Then as fermenting under the conditions of 35 DEG C, during fermentation, acetobacter and glucose oxidation and bacillus, acetobacter and grape glycosyloxy are added
It is the 0.5% and 0.3% of fig weight respectively to change bacillus additive amount, microwave treatment in fermentation process, the microwave treatment
Condition be 1.05kHz, power 500W, the time is daily 25s, fermentation 1-3 days filtering, obtain fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds the weight of complex enzyme and 2 parts of water, the fig and complex enzyme
Amount is than being 100: 2；The complex enzyme is papain, the mixture of glucoamylase, papain, and glucose forms sediment
The mass ratio of powder enzyme is 1: 4, and enzymolysis, isolates supernatant and solid slag；Supernatant and solid slag are dried respectively, mixed
Close, obtain fiber；
(3) medicament is prepared：Weigh except other raw materials of fig mix；3000 parts of room temperature are added into the medicament mixed
Water, soaks 30 minutes；After boiling by intense fire, continue to decoct 50 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；To described
2500 parts of normal-temperature waters are added in the dregs of a decoction, using being cooked by slow fire 45 minutes, filters, obtains secondary liquid；By a liquid and secondary medicine
Liquid merges, and the merging medicament that step (3) has boiled is purified with ethanol water bath, and the triethanolamine of 0.3mL is added after sterilizing, is made
Aqueous solution, adds 3.5g glycerin monostearates and 3g vaseline in aqueous, and 80 DEG C of stirring in water bath, are made paste, then
The fiber that the azone of addition paste 5%, 10% 1,2-PD, 30% dimethyl sulfoxide (DMSO), step (2) are prepared,
Condensation is continuously stirring to, liniment is made, that is, obtains the Chinese traditional medicine composition liniment of one treatment mastitis for milk cows.
Embodiment 3：
Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing, said composition is prepared by following raw materials and consumption：It is yellow
18 parts of a kind of reed mentioned in ancient books, 17 parts of Radix Salviae Miltiorrhizae, 28 parts of Fructus Forsythiae, 16 parts of safflower, 17 parts of Angelica sinensis, 19 parts of garden burnet, 27 parts of dandelion, 16 parts of giant knotweed, frankincense
17 parts, 16 parts of myrrh, 26 parts of honeysuckle, 17 parts of radix glycyrrhizae, 19 parts of oldenlandia diffusa, 19 parts of rhizoma cyperi, 56 parts of fig.
Process for preparing medicine is wiped outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows, is comprised the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water
Solid-liquid ratio is 1: 1.8, carries out ultrasonication, and the condition of ultrasonication is 25kHz, power 280W, time 0.5h, so
Afterwards as fermenting under the conditions of 30 DEG C, during fermentation, add acetobacter and glucose oxidation and bacillus, acetobacter and grape are glycoxidative
Bacillus additive amount is the 0.5% and 0.3% of fig weight respectively, microwave treatment in fermentation process, the microwave treatment
Condition is 1.05kHz, and power 500W, the time is daily 25s, ferments 1-3 days and filters, obtains fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds the weight of complex enzyme and 2 parts of water, the fig and complex enzyme
Amount is than being 100: 1；The complex enzyme is papain, the mixture of glucoamylase, papain, and glucose forms sediment
The mass ratio of powder enzyme is 1: 4, and enzymolysis, isolates supernatant and solid slag；Supernatant and solid slag are dried respectively, mixed
Close, obtain fiber；
(3) medicament is prepared：Weigh except other raw materials of fig mix；3000 parts of room temperature are added into the medicament mixed
Water, soaks 30 minutes；After boiling by intense fire, continue to decoct 50 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；To described
2000 parts of normal-temperature waters are added in the dregs of a decoction, using being cooked by slow fire 45 minutes, filters, obtains secondary liquid；By a liquid and secondary medicine
Liquid merges, and the merging medicament that step (3) has boiled is purified with ethanol water bath, and the triethanolamine of 0.3mL is added after sterilizing, is made
Aqueous solution, adds 3.5g glycerin monostearates and 3g vaseline in aqueous, and 80 DEG C of stirring in water bath, are made paste, then
The fiber that the azone of addition paste 5%, 10% 1,2-PD, 30% dimethyl sulfoxide (DMSO), step (2) are prepared,
Condensation is continuously stirring to, liniment is made, that is, obtains the Chinese traditional medicine composition liniment of one treatment mastitis for milk cows.
Embodiment 4
Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing, said composition is prepared by following raw materials and consumption：It is yellow
12 parts of a kind of reed mentioned in ancient books, 13 parts of Radix Salviae Miltiorrhizae, 21 parts of Fructus Forsythiae, 11 parts of safflower, 13 parts of Angelica sinensis, 12 parts of garden burnet, 21 parts of dandelion, 13 parts of giant knotweed, frankincense
11 parts, 13 parts of myrrh, 22 parts of honeysuckle, 11 parts of radix glycyrrhizae, 13 parts of oldenlandia diffusa, 12 parts of rhizoma cyperi, 33 parts of fig.
Process for preparing medicine is wiped outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows, is comprised the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water
Solid-liquid ratio is 1: 1.8, carries out ultrasonication, and the condition of ultrasonication is 20kHz, power 250W, time 1h, then
As for fermenting under the conditions of 25 DEG C, during fermentation, acetobacter and glucose oxidation and bacillus, acetobacter and the glycoxidative bar of grape are added
Bacterium additive amount is the 0.5% and 0.3% of fig weight respectively, microwave treatment in fermentation process, the bar of the microwave treatment
Part is 1.05kHz, and power 500W, the time is daily 25s, ferments 1-3 days and filters, obtains fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds the weight of complex enzyme and 2 parts of water, the fig and complex enzyme
Amount is than being 100: 1.5；The complex enzyme is papain, the mixture of glucoamylase, papain, grape
The mass ratio of saccharogenic amylase is 1: 4, and enzymolysis, isolates supernatant and solid slag；Supernatant and solid slag are dried respectively,
Mixing, obtains fiber；
(3) medicament is prepared：Weigh except other raw materials of fig mix；3000 parts of room temperature are added into the medicament mixed
Water, soaks 30 minutes；After boiling by intense fire, continue to decoct 50 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；To described
2000 parts of normal-temperature waters are added in the dregs of a decoction, using being cooked by slow fire 45 minutes, filters, obtains secondary liquid；By a liquid and secondary medicine
Liquid merges, and the merging medicament that step (3) has boiled is purified with ethanol water bath, and the triethanolamine of 0.3mL is added after sterilizing, is made
Aqueous solution, adds 3.5g glycerin monostearates and 3g vaseline in aqueous, and 80 DEG C of stirring in water bath, are made paste, then
The fiber that the azone of addition paste 5%, 10% 1,2-PD, 30% dimethyl sulfoxide (DMSO), step (2) are prepared,
Condensation is continuously stirring to, liniment is made, that is, obtains the Chinese traditional medicine composition liniment of one treatment mastitis for milk cows.
Embodiment 5
Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing, said composition is prepared by following raw materials and consumption：It is yellow
14 parts of a kind of reed mentioned in ancient books, 15 parts of Radix Salviae Miltiorrhizae, 27 parts of Fructus Forsythiae, 13 parts of safflower, 16 parts of Angelica sinensis, 18 parts of garden burnet, 26 parts of dandelion, 15 parts of giant knotweed, frankincense
16 parts, 14 parts of myrrh, 25 parts of honeysuckle, 16 parts of radix glycyrrhizae, 18 parts of oldenlandia diffusa, 17 parts of rhizoma cyperi, 50 parts of fig.
Process for preparing medicine is wiped outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows, is comprised the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water
Solid-liquid ratio is 1: 1.9, carries out ultrasonication, and the condition of ultrasonication is 20kHz, power 230W, time 0.5h, so
Afterwards as fermenting under the conditions of 30 DEG C, during fermentation, add acetobacter and glucose oxidation and bacillus, acetobacter and grape are glycoxidative
Bacillus additive amount is the 0.5% and 0.3% of fig weight respectively, microwave treatment in fermentation process, the microwave treatment
Condition is 1.05kHz, and power 500W, the time is daily 25s, ferments 1-3 days and filters, obtains fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds the weight of complex enzyme and 2 parts of water, the fig and complex enzyme
Amount is than being 100: 2；The complex enzyme is papain, the mixture of glucoamylase, papain, and glucose forms sediment
The mass ratio of powder enzyme is 1: 4, and enzymolysis, isolates supernatant and solid slag；Supernatant and solid slag are dried respectively, mixed
Close, obtain fiber；
(3) medicament is prepared：Weigh except other raw materials of fig mix；3000 parts of room temperature are added into the medicament mixed
Water, soaks 30 minutes；After boiling by intense fire, continue to decoct 40 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；To described
2000 parts of normal-temperature waters are added in the dregs of a decoction, using being cooked by slow fire 40 minutes, filters, obtains secondary liquid；By a liquid and secondary medicine
Liquid merges, and the merging medicament that step (3) has boiled is purified with ethanol water bath, and the triethanolamine of 0.3mL is added after sterilizing, is made
Aqueous solution, adds 3.5g glycerin monostearates and 3g vaseline in aqueous, and 80 DEG C of stirring in water bath, are made paste, then
The fiber that the azone of addition paste 5%, 10% 1,2-PD, 30% dimethyl sulfoxide (DMSO), step (2) are prepared,
Condensation is continuously stirring to, liniment is made, that is, obtains the Chinese traditional medicine composition liniment of one treatment mastitis for milk cows.
Following table is to be counted using the traditional Chinese medicine composition for treating mastitis for milk cows result of the present invention
| Treat case | Treat number | Cure number | It is dead to wash in a pan number | Cure rate % |
| 1 | 100 | 98 | 2 | 98 |
| 2 | 100 | 99 | 1 | 99 |
| 3 | 100 | 98 | 2 | 98 |
| 4 | 100 | 98 | 2 | 98 |
| 5 | 100 | 98 | 2 | 98 |
The present invention has good therapeutic effect to mastitis for milk cows as can be seen from the table.
The above is only the preferred embodiment of the present invention, it should be pointed out that：For the ordinary skill people of the art
For member, without departing from the principle of the present invention, some improvement can also be made, these improvement should be regarded as the guarantor of the present invention
Protect scope.
Claims (8)
1. thing of applying medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows, it is characterised in that said composition is by following raw material and use
Amount is prepared：10-20 parts of radix scutellariae, 10-20 parts of Radix Salviae Miltiorrhizae, 20-30 parts of Fructus Forsythiae, 10-20 parts of safflower, 10-20 parts of Angelica sinensis, garden burnet 10-20
Part, 20-30 parts of dandelion, 10-20 parts of giant knotweed, 10-20 parts of frankincense, 10-20 parts of myrrh, 20-30 parts of honeysuckle, radix glycyrrhizae 10-20
Part, 10-20 parts of oldenlandia diffusa, 10-20 parts of rhizoma cyperi, 30-60 parts of fig.
2. apply medicinal lotion or ointment thing outside the Chinese traditional medicine composition for the treatment of mastitis for milk cows as claimed in claim 1, it is characterised in that said composition by
Following raw materials and consumption is prepared：12-18 parts of radix scutellariae, 13-17 parts of Radix Salviae Miltiorrhizae, 21-28 parts of Fructus Forsythiae, 11-16 parts of safflower, Angelica sinensis 13-17
Part, 12-19 parts of garden burnet, 21-27 parts of dandelion, 13-16 parts of giant knotweed, 11-17 parts of frankincense, 13-16 parts of myrrh, honeysuckle 22-26
Part, 11-17 parts of radix glycyrrhizae, 13-19 parts of oldenlandia diffusa, 12-19 parts of rhizoma cyperi, 33-56 parts of fig.
3. apply medicinal lotion or ointment thing outside the Chinese traditional medicine composition for the treatment of mastitis for milk cows as claimed in claim 1, it is characterised in that said composition by
Following raw materials and consumption is prepared：14 parts of radix scutellariae, 15 parts of Radix Salviae Miltiorrhizae, 27 parts of Fructus Forsythiae, 13 parts of safflower, 16 parts of Angelica sinensis, 18 parts of garden burnet, Pu Gong
26 parts of English, 15 parts of giant knotweed, 16 parts of frankincense, 14 parts of myrrh, 25 parts of honeysuckle, 16 parts of radix glycyrrhizae, 18 parts of oldenlandia diffusa, rhizoma cyperi 17
Part, 50 parts of fig.
4. a kind of preparation method for thing of applying medicinal lotion or ointment outside Chinese traditional medicine composition for the treatment of mastitis for milk cows as claimed in claim 1, its feature
It is, comprises the following steps：
(1) fig is weighed by above-mentioned composition proportioning, pure water will be added in fig, be made into fig and pure water feed liquid
Than for 1: 1.6-1.9, carrying out ultrasonication, then as fermenting under the conditions of 25-35 DEG C, microwave treatment in fermentation process, hair
Ferment filters for 1-3 days, obtains fermentation residue；
(2) fermentation residue is cleaned 1-3 times with pure water, adds complex enzyme and 2 parts of water, digested, isolate supernatant and solid slag；Point
Other that supernatant and solid slag are dried, mixing, obtains fiber；
(3) other raw materials mixing except fig is weighed；2500~3000 parts of normal-temperature waters of middle addition into the medicament mixed, leaching
Bubble 30 minutes；After boiling by intense fire, continue to decoct 40~50 minutes using slow boiling, filtering, obtains the dregs of a decoction and a liquid；To the medicine
2000~2500 parts of normal-temperature waters are added in slag, using being cooked by slow fire 40~45 minutes, filters, obtains secondary liquid；By a liquid
Merge with secondary liquid；
(4) the merging medicament that step (3) has boiled is purified with ethanol water bath, the triethanolamine of 0.3mL is added after sterilizing, is made
Aqueous solution, adds 3.5g glycerin monostearates and 3g vaseline in aqueous, and 80 DEG C of stirring in water bath, are made paste, then
The fiber that the azone of addition paste 5%, 10% 1,2-PD, 30% dimethyl sulfoxide (DMSO), step (2) are prepared,
Condensation is continuously stirring to, liniment is made, that is, obtains the Chinese traditional medicine composition liniment of one treatment mastitis for milk cows.
5. the preparation method for thing of applying medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows according to claim 4, it is special
Sign is：In the ferment at constant temperature described in step (1), acetobacter and glucose oxidation and bacillus, acetobacter and grape are added
Glycoxidative bacillus additive amount is the 0.5% and 0.3% of fig weight respectively.
6. the preparation method for thing of applying medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows according to claim 4, it is special
Sign is：The condition of the ultrasonication is 20-25kHz, power 200-280W, time 0.5-1h.
7. the preparation method for thing of applying medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows according to claim 4, it is special
Sign is：The condition of the microwave treatment is 1.05kHz, power 500W, time 25s.
8. the preparation method for thing of applying medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows according to claim 4, it is special
Sign is：The complex enzyme and the weight ratio of fig are 100: 1-2；The complex enzyme is papain, glucose
The mixture of amylase, papain, the mass ratio of glucoamylase is 1: 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711210247.6A CN107951972A (en) | 2017-11-27 | 2017-11-27 | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711210247.6A CN107951972A (en) | 2017-11-27 | 2017-11-27 | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107951972A true CN107951972A (en) | 2018-04-24 |
Family
ID=61959459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711210247.6A Pending CN107951972A (en) | 2017-11-27 | 2017-11-27 | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107951972A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110740785A (en) * | 2017-05-01 | 2020-01-31 | I·E·基亚尼 | Antiviral compositions and methods |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965976A (en) * | 2006-11-05 | 2007-05-23 | 武瑞 | Chinese medicinal composition for preventing and treating cow mastitis |
| CN102488814A (en) * | 2011-12-22 | 2012-06-13 | 中国农业科学院北京畜牧兽医研究所 | Chinese medicinal composition for treating bovine mastitis |
| CN102972779A (en) * | 2012-12-11 | 2013-03-20 | 长沙理工大学 | Method for preparing dietary fiber of lotus seed shells by virtue of microwave-assisted enzymolysis |
| CN103142776A (en) * | 2013-03-08 | 2013-06-12 | 青岛农业大学 | Traditional Chinese medicine composition for treating endometritis of sheep and preparation method thereof |
| CN103751509A (en) * | 2014-01-13 | 2014-04-30 | 黑龙江八一农垦大学 | Chinese herbal medicine composition for treating clinical mastitis |
| CN105726734A (en) * | 2016-04-08 | 2016-07-06 | 吉林农业科技学院 | Liniment for treating cow mastitis and preparation method thereof |
| CN105832891A (en) * | 2016-05-30 | 2016-08-10 | 青岛海之源智能技术有限公司 | Injection for treating mastitis of female minks and preparation method of injection |
-
2017
- 2017-11-27 CN CN201711210247.6A patent/CN107951972A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965976A (en) * | 2006-11-05 | 2007-05-23 | 武瑞 | Chinese medicinal composition for preventing and treating cow mastitis |
| CN102488814A (en) * | 2011-12-22 | 2012-06-13 | 中国农业科学院北京畜牧兽医研究所 | Chinese medicinal composition for treating bovine mastitis |
| CN102972779A (en) * | 2012-12-11 | 2013-03-20 | 长沙理工大学 | Method for preparing dietary fiber of lotus seed shells by virtue of microwave-assisted enzymolysis |
| CN103142776A (en) * | 2013-03-08 | 2013-06-12 | 青岛农业大学 | Traditional Chinese medicine composition for treating endometritis of sheep and preparation method thereof |
| CN103751509A (en) * | 2014-01-13 | 2014-04-30 | 黑龙江八一农垦大学 | Chinese herbal medicine composition for treating clinical mastitis |
| CN105726734A (en) * | 2016-04-08 | 2016-07-06 | 吉林农业科技学院 | Liniment for treating cow mastitis and preparation method thereof |
| CN105832891A (en) * | 2016-05-30 | 2016-08-10 | 青岛海之源智能技术有限公司 | Injection for treating mastitis of female minks and preparation method of injection |
Non-Patent Citations (2)
| Title |
|---|
| 胡郁坤 等主编: "《中医单方全书》", 30 June 2012, 湖南科学技术出版社 * |
| 齐艳梅等: "介绍几种奶牛乳房炎的治疗方法 ", 《北方牧业》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110740785A (en) * | 2017-05-01 | 2020-01-31 | I·E·基亚尼 | Antiviral compositions and methods |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102145111B (en) | Traditional Chinese medicine composition for treating colpitis mycotica and preparation method thereof | |
| CN103652501B (en) | Feed for treating cow mastitis and preparation method thereof | |
| CN103800772A (en) | Gynecological external lotion for preventing and treating vagina inflammatory diseases and preparation method thereof | |
| CN106804643A (en) | A kind of clinical laboratory Chinese medicine sterilizing thimerosal | |
| CN102579701B (en) | Compound dandelion decoction | |
| CN109364207A (en) | A kind of composition and preparation method and the application for the treatment of and alleviation acne | |
| CN102847021B (en) | Enema for treating ulcerative colitis and preparation method thereof | |
| CN101987166B (en) | Medicament for treating stye and preparation method thereof | |
| CN107823375A (en) | A kind of Chinese medicinal tablet for treating mastitis for milk cows and preparation method thereof | |
| CN108853277A (en) | A kind of Traditional Chinese medicine disinfectant for acupuncture | |
| CN101391065B (en) | Compound momordica seed pepper soup for treating urgent chronic pelvic inflammatory disease | |
| CN103656048B (en) | Medicine being used for the treatment of mammitis of cow and preparation method thereof | |
| CN101439114B (en) | Chinese medicine for treating burn and scald, and preparation method thereof | |
| CN105816594A (en) | Medicinal composition for treating acne as well as preparation method and application of medicinal composition | |
| CN107998242A (en) | A kind of Chinese medicine composition for treating mastitis for milk cows and preparation method thereof | |
| CN107951972A (en) | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof | |
| CN103099885A (en) | Soft capsules having acne removing function and preparation method thereof | |
| CN107890502A (en) | A kind of Chinese traditional medicine composition dabbling drug for treating mastitis for milk cows and preparation method thereof | |
| CN101953951B (en) | Hand and feed health-care and beautifying liquid and preparation method thereof | |
| CN110585379A (en) | External application medicine for treating dermatitis | |
| CN104435244A (en) | Traditional Chinese medicine composition for effectively treating mammary cancer | |
| CN109248244A (en) | A kind of Chinese medicine and preparation method thereof for treating gynaecological imflammation | |
| CN107095961A (en) | A kind of instant particles as Chinese medicine and preparation method for being used to treat adolescent acne | |
| CN106474236A (en) | A kind of treat pharmaceutical composition of pruitus and preparation method thereof | |
| CN1927273A (en) | Bath agent for influenza defervesce and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180424 |