CN109248244A - A kind of Chinese medicine and preparation method thereof for treating gynaecological imflammation - Google Patents
A kind of Chinese medicine and preparation method thereof for treating gynaecological imflammation Download PDFInfo
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- CN109248244A CN109248244A CN201811360017.2A CN201811360017A CN109248244A CN 109248244 A CN109248244 A CN 109248244A CN 201811360017 A CN201811360017 A CN 201811360017A CN 109248244 A CN109248244 A CN 109248244A
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- gynaecological imflammation
- chinese medicine
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Abstract
The invention discloses a kind of Chinese medicines for treating gynaecological imflammation, are related to technical field of traditional Chinese medicines, the Chinese medicine of the treatment gynaecological imflammation includes raw material below: Caulis Spatholobi, alpine yarrow, field pennycress, dandelion, Radix Glycyrrhizae, dragon's blood, honeysuckle, motherwort, Cortex Phellodendri.The invention also discloses the preparation methods of the Chinese medicine of the treatment gynaecological imflammation.In order to solve the problems, such as using broad-spectrum antibiotic therapy gynaecological imflammation easily lead to body it is bacterial resistance occurred and gradually decrease therapeutic effect easily to body generate side effect, the present invention is cooperated by Caulis Spatholobi, alpine yarrow and field pennycress, assisting ultrasonic processing simultaneously, fungistatic effect can be effectively improved, due to being prepared using plurality of Chinese raw material, to human body Small side effects, and it is not easy to keep body bacterial resistance occurred, it is effectively ensured to the therapeutic effect to gynaecological imflammation, also there is good opsonic action to human immune system, have a vast market foreground.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, the Chinese medicine and preparation method thereof of specifically a kind for the treatment of gynaecological imflammation.
Background technique
Due to the relatively special physiological structure of women, it is easy to infect various bacteriums, fungi and mould etc. to induce woman
Section's inflammation.Gynaecological imflammation is primarily referred to as the inflammation of female sex organ, such as female vulva as a kind of women common disease
Inflammation, vaginitis, cervicitis, pelvic inflammatory disease etc..If inflammation cannot get timely medical treatment, less serious case may cause inflammation in each physiology portion
Outside position mutually sprawling and cross-infection, severe one results even in the malignant change at certain positions.
Doctor trained in Western medicine mostly uses broad-spectrum antibiotic therapy gynaecological imflammation at present, although having certain therapeutic effect, use
Antibiotic is easy to cause body bacterial resistance occurred and gradually decreases therapeutic effect, meanwhile, easily body is produced using antibiotic
Raw side effect, such as the long-term abuse potential of antibiotic lead to the damage of the built-in organ of patient, can also cause vaginal dysbacteriosis
And immunity function is low, induces candidal vaginitis etc..Therefore, it is necessary to design the treatment that a kind of therapeutic effect is good and side effect is low
The Chinese medicine of gynaecological imflammation.
Summary of the invention
The purpose of the present invention is to provide a kind of Chinese medicines and preparation method thereof for treating gynaecological imflammation, to solve above-mentioned background
The problem of proposing in technology, the present invention pass through with Caulis Spatholobi, alpine yarrow, field pennycress, dandelion, Radix Glycyrrhizae, dragon's blood, honeysuckle, benefit
The plurality of Chinese raw material such as Brittle Falsepimpernel Herb, Cortex Phellodendri carries out reasonable compatibility, to human body Small side effects, and is not easy that body bacterium is made to generate anti-medicine
Property, it has been effectively ensured to the therapeutic effect to gynaecological imflammation, also there is good opsonic action to the immune system of human body.
To achieve the above object, the invention provides the following technical scheme:
A kind of Chinese medicine for treating gynaecological imflammation, including below according to the raw material of parts by weight: 30-46 parts of Caulis Spatholobi, alpine yarrow
20-30 parts, 15-21 parts of field pennycress, 6-10 parts of dandelion, 10-18 parts of Radix Glycyrrhizae, 5-9 parts of dragon's blood, 8-14 parts of honeysuckle, motherwort
12-18 parts, 3-7 parts of Cortex Phellodendri.
As a further solution of the present invention: including below according to the raw material of parts by weight: 34-42 parts of Caulis Spatholobi, alpine yarrow
22-28 parts, 16-20 parts of field pennycress, 7-9 parts of dandelion, 12-16 parts of Radix Glycyrrhizae, 6-8 parts of dragon's blood, 10-12 parts of honeysuckle, motherwort
13-17 parts, 4-6 parts of Cortex Phellodendri.
As further scheme of the invention: including below according to the raw material of parts by weight: 38 parts of Caulis Spatholobi, alpine yarrow 25
Part, 18 parts of field pennycress, 8 parts of dandelion, 14 parts of Radix Glycyrrhizae, 7 parts of dragon's blood, 11 parts of honeysuckle, 15 parts of motherwort, 5 parts of Cortex Phellodendri.
As further scheme of the invention: the Chinese medicine of the treatment gynaecological imflammation further includes pharmaceutically acceptable load
Body and/or excipient.
The preparation method of the Chinese medicine of the treatment gynaecological imflammation, steps are as follows:
1) according to parts by weight weigh Caulis Spatholobi, alpine yarrow, field pennycress, dandelion and Radix Glycyrrhizae cleaned respectively with deionized water it is dry
Only, it is put into jointly after drying and carries out being crushed to 20 mesh into pulverizer, obtain mixture A；
2) water of 6-12 times of volume will be added in mixture A obtained in step 1), then use supersonic wave wall breaking technology
It is ultrasonically treated, obtains mixture B；By ultrasonic treatment, is conducive to water and enters the intracellular progress sufficiently dilution of raw material effectively
Sufficiently, the extraction effect to raw material is effectively increased, while being conducive to the subsequent decoction to medicinal material；
3) mixture B obtained in step 2) is conventionally subjected to decoction 3h, decoction liquor is then subjected to 200 mesh
Then the medicinal extract that relative density is 1.13 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C is sprayed using conventional method
Mist is dry, obtains mixture C；
4) dragon's blood, honeysuckle, motherwort and Cortex Phellodendri are weighed according to parts by weight, uses volume fraction for 70% after mixing
Ethyl alcohol conventionally carry out refluxing extraction three times, 30 minutes every time, be then combined with three times extracting solution carry out 200 mesh mistakes
Relative density is 1.18 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C, is then spray-dried, is obtained using conventional method
Mixture D；
5) mixture C obtained in step 3) is uniformly mixed with mixture D obtained in step 4), is sterilized, i.e.,
?.
As further scheme of the invention: in step 2), the condition of the ultrasonic treatment is that ultrasonic power is
120W, ultrasonic time 30min；The water is aseptic deionized water or distilled water or pure water.
As the present invention further scheme: in step 3), in the decoction process using acetic acid and sodium bicarbonate into
The pH that row adjusts water body is maintained at 8-10.
As further scheme of the invention: in step 5), described further include being added pharmaceutically connect after mixing
Preparation is made in the carrier and/or excipient and use this field conventional preparation method received.
Application of the Chinese medicine of the treatment gynaecological imflammation in preparation treatment gynaecological imflammation drug.
The pharmacological property and pharmacology of various Chinese medicines of the present invention are respectively as follows:
The effect of Caulis Spatholobi, Chinese medicine name is warm-natured, bitter but slightly sweet taste, returns liver, the heart, kidney channel, has and activates blood and relax tendons, nourishing blood for regulating menstruation；
Rheumatic arthralgia is cured mainly, numb in every limb, quadriplegia, irregular menstruation, blockage of menstruation, dysmenorrhea, menostasis, leukopenia has
Expand blood vessel, platelet aggregation-against, promote the effects of phosphorus metabolism, rheumatic arthritis, erythematosus lupus, blood platelet can also be treated and subtracted
Less, the diseases such as acute diarrhea.
Alpine yarrow, Chinese medicine name are Scrophulariaceae Brittle Falsepimpernel Herb platymiscium tingia Brittle Falsepimpernel Herb, mild-natured with all herbal medicine, lightly seasoned, are had
Clearing heat and detoxicating, addiction of dispelling detumescence, analgesic and other effects can be used for venomous snake bite, traumatic injury, postpartum addiction hemoperitoneum pain.
Field pennycress, Chinese medicine name is the drying herb of patrinia herb patrima villosa, cool in nature, acrid flavour, hardship, enters liver, stomach, big
Intestines warp, has the effect of clearing heat and detoxicating, eliminating the phlegm apocenosis, is usually used in acute appendicitis, pulmonary abscess, dysentery, postpartum blood stasis abdominal pain, carbuncle swells furunculosis.
Dandelion, Chinese medicine name, alias dandelion, Po Poding, Hua Hualang etc. are compositae plant dandelion, alkali ground Pu
Public English or the drying herb for belonging to several plants, it is bitter, sweet, it is cold in nature, it is mainly used for furuncle swelling toxin, acute mastitis, scrofula, hot eyes, pharynx
Bitterly, pulmonary abscess, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea etc..
Radix Glycyrrhizae, it is mild-natured, sweet in flavor, enter 12 warps, Radix Glycyrrhizae, which has, invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain,
The functions such as coordinating the drug actions of a prescription are usually used in weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, carbuncle sore tumefacting virus, can be with abirritant
It is object toxicity, strong.
Dragon's blood has and dissipates addiction analgesic therapy, and the effect of hemostasia and promoting granulation, it is more than can to control traumatic injury, internal injury addiction pain, traumatic hemorrhage
Deng.
Honeysuckle, energy dispelling wind-heat, also kind removing summer-heat blood poison are used for various febrile diseases, such as body heat, dermexanthesis, macular eruption, heat toxin sore
Carbuncle, abscess of throat.
Motherwort, it is acrid flavour, hardship, cool in nature, have that promoting blood circulation, addiction of dispelling, menstruation regulating, disappear water and other effects.
Cortex Phellodendri, bitter is cold in nature, enters kidney, bladder, large intestine channel, has heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment and other effects；
It is common to control damp-heat dysentery, yellow subcutaneous ulcer, leukorrhagia, heat gonorrhea, tinea pedis, night sweat, spermatorrhea, sore swollen toxin, the diseases such as eczema itch.
Compared with prior art, the beneficial effects of the present invention are:
1) Chinese medicine compound prescription prepared by the present invention to gynaecological imflammation have good therapeutic effect, the present invention by Caulis Spatholobi,
Alpine yarrow and field pennycress cooperate, while assisting ultrasonic is handled, and play synergistic effect, can effectively improve antibacterial
Effect is especially had excellent fungistatic effect to Candida albicans, solves and easily led using broad-spectrum antibiotic therapy gynaecological imflammation
It causes body bacterial resistance occurred and gradually decreases therapeutic effect and side effect easily is led to the problem of to body；
2) by more with Caulis Spatholobi, alpine yarrow, field pennycress, dandelion, Radix Glycyrrhizae, dragon's blood, honeysuckle, motherwort, Cortex Phellodendri etc.
Kind Chinese medicine material carries out reasonable compatibility, is conducive to improve the therapeutic effect to gynaecological imflammation, due to being former using plurality of Chinese
Material is prepared, and to the Small side effects of human body, and is not easy to keep body bacterial resistance occurred, has been effectively ensured to gynaecology
The therapeutic effect of inflammation, avoid using broad-spectrum antibiotic therapy gynaecological imflammation easily lead to body it is bacterial resistance occurred and gradually
Reduce the drawbacks of therapeutic effect easily generates side effect to body；Also by ultrasonic treatment, is conducive to water and enters the intracellular of raw material
It is effectively abundant to carry out sufficiently dilution, effectively increases the extraction effect to raw material, while being conducive to the subsequent decoction to medicinal material；
3) present invention uses plurality of Chinese compatibility, not only has good fungistatic effect, also has to the immune system of human body
There is good opsonic action, effectively increases body to the immunocompetence of bacterium, have a vast market foreground.
Specific embodiment
Technical solution of the present invention is described in more detail With reference to embodiment.
Embodiment 1
A kind of Chinese medicine for treating gynaecological imflammation, including below according to the raw material of parts by weight: 30 parts of Caulis Spatholobi, alpine yarrow 20
Part, 15 parts of field pennycress, 6 parts of dandelion, 10 parts of Radix Glycyrrhizae, 5 parts of dragon's blood, 8 parts of honeysuckle, 12 parts of motherwort, 3 parts of Cortex Phellodendri；Further include
Pharmaceutically acceptable carrier；By with Caulis Spatholobi, alpine yarrow, field pennycress, dandelion, Radix Glycyrrhizae, dragon's blood, honeysuckle, motherwort,
The plurality of Chinese raw material such as Cortex Phellodendri carries out reasonable compatibility, is conducive to improve the therapeutic effect to gynaecological imflammation.
In the present embodiment, the preparation method of the Chinese medicine of the treatment gynaecological imflammation, steps are as follows:
1) according to parts by weight weigh Caulis Spatholobi, alpine yarrow, field pennycress, dandelion and Radix Glycyrrhizae cleaned respectively with deionized water it is dry
Only, it is put into jointly after drying and carries out being crushed to 20 mesh into pulverizer, obtain mixture A；
2) water of 6 times of volumes will be added in mixture A obtained in step 1), then carried out using supersonic wave wall breaking technology
Ultrasonic treatment, obtains mixture B；The condition of the ultrasonic treatment is that ultrasonic power is 120W, ultrasonic time 30min；The water
For aseptic deionized water；By ultrasonic treatment, be conducive to water enter raw material intracellular progress sufficiently dilution it is effective abundant, effectively
The extraction effect to raw material is improved, while being conducive to the subsequent decoction to medicinal material；
3) mixture B obtained in step 2) is conventionally subjected to decoction 3h, decoction liquor is then subjected to 200 mesh
Then the medicinal extract that relative density is 1.13 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C is sprayed using conventional method
Mist is dry, obtains mixture C；
Wherein, 8 are maintained at using the pH that water body is adjusted in acetic acid and sodium bicarbonate in the decoction process；
4) dragon's blood, honeysuckle, motherwort and Cortex Phellodendri are weighed according to parts by weight, uses volume fraction for 70% after mixing
Ethyl alcohol conventionally carry out refluxing extraction three times, 30 minutes every time, be then combined with three times extracting solution carry out 200 mesh mistakes
Relative density is 1.18 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C, is then spray-dried, is obtained using conventional method
Mixture D；
5) mixture C obtained in step 3) is uniformly mixed with mixture D obtained in step 4), is sterilized, i.e.,
?；Described further include that pharmaceutically acceptable carrier (such as deionized water) is added and uses this field conventional formulation after mixing
Preparation is made in method.
In the present embodiment, application of the Chinese medicine of the treatment gynaecological imflammation in preparation treatment gynaecological imflammation drug.
Embodiment 2
A kind of Chinese medicine for treating gynaecological imflammation, including below according to the raw material of parts by weight: 46 parts of Caulis Spatholobi, alpine yarrow 30
Part, 21 parts of field pennycress, 10 parts of dandelion, 18 parts of Radix Glycyrrhizae, 9 parts of dragon's blood, 14 parts of honeysuckle, 18 parts of motherwort, 7 parts of Cortex Phellodendri；Also wrap
Include pharmaceutically acceptable excipient；By with Caulis Spatholobi, alpine yarrow, field pennycress, dandelion, Radix Glycyrrhizae, dragon's blood, honeysuckle, benefit
The plurality of Chinese raw material such as Brittle Falsepimpernel Herb, Cortex Phellodendri carries out reasonable compatibility, is conducive to improve the therapeutic effect to gynaecological imflammation.
In the present embodiment, the preparation method of the Chinese medicine of the treatment gynaecological imflammation, steps are as follows:
1) according to parts by weight weigh Caulis Spatholobi, alpine yarrow, field pennycress, dandelion and Radix Glycyrrhizae cleaned respectively with deionized water it is dry
Only, it is put into jointly after drying and carries out being crushed to 20 mesh into pulverizer, obtain mixture A；
2) will in mixture A obtained in step 1) be added 12 times of volumes water, then using supersonic wave wall breaking technology into
Row ultrasonic treatment, obtains mixture B；The condition of the ultrasonic treatment is that ultrasonic power is 120W, ultrasonic time 30min；It is described
Water is distilled water；By ultrasonic treatment, be conducive to water enter raw material intracellular progress sufficiently dilution it is effective abundant, effectively improve
To the extraction effect of raw material, while being conducive to the subsequent decoction to medicinal material；
3) mixture B obtained in step 2) is conventionally subjected to decoction 3h, decoction liquor is then subjected to 200 mesh
Then the medicinal extract that relative density is 1.13 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C is sprayed using conventional method
Mist is dry, obtains mixture C；
Wherein, 10 are maintained at using the pH that water body is adjusted in acetic acid and sodium bicarbonate in the decoction process；
4) dragon's blood, honeysuckle, motherwort and Cortex Phellodendri are weighed according to parts by weight, uses volume fraction for 70% after mixing
Ethyl alcohol conventionally carry out refluxing extraction three times, 30 minutes every time, be then combined with three times extracting solution carry out 200 mesh mistakes
Relative density is 1.18 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C, is then spray-dried, is obtained using conventional method
Mixture D；
5) mixture C obtained in step 3) is uniformly mixed with mixture D obtained in step 4), is sterilized, i.e.,
?；Described further include that pharmaceutically acceptable excipient is added and is made of this field conventional preparation method after mixing
Agent.
In the present embodiment, application of the Chinese medicine of the treatment gynaecological imflammation in preparation treatment gynaecological imflammation drug.
Embodiment 3
A kind of Chinese medicine for treating gynaecological imflammation, including below according to the raw material of parts by weight: 34 parts of Caulis Spatholobi, alpine yarrow 22
Part, 16 parts of field pennycress, 7 parts of dandelion, 12 parts of Radix Glycyrrhizae, 6 parts of dragon's blood, 10 parts of honeysuckle, 13 parts of motherwort, 4 parts of Cortex Phellodendri；Further include
Pharmaceutically acceptable carrier and excipient；By with Caulis Spatholobi, alpine yarrow, field pennycress, dandelion, Radix Glycyrrhizae, dragon's blood, gold and silver
The plurality of Chinese raw material such as flower, motherwort, Cortex Phellodendri carries out reasonable compatibility, is conducive to improve the therapeutic effect to gynaecological imflammation.
In the present embodiment, the preparation method of the Chinese medicine of the treatment gynaecological imflammation, steps are as follows:
1) according to parts by weight weigh Caulis Spatholobi, alpine yarrow, field pennycress, dandelion and Radix Glycyrrhizae cleaned respectively with deionized water it is dry
Only, it is put into jointly after drying and carries out being crushed to 20 mesh into pulverizer, obtain mixture A；
2) water of 6 times of volumes will be added in mixture A obtained in step 1), then carried out using supersonic wave wall breaking technology
Ultrasonic treatment, obtains mixture B；The condition of the ultrasonic treatment is that ultrasonic power is 120W, ultrasonic time 30min；The water
For pure water；By ultrasonic treatment, be conducive to water enter raw material intracellular progress sufficiently dilution it is effective abundant, effectively increase
To the extraction effect of raw material, while being conducive to the subsequent decoction to medicinal material；
3) mixture B obtained in step 2) is conventionally subjected to decoction 3h, decoction liquor is then subjected to 200 mesh
Then the medicinal extract that relative density is 1.13 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C is sprayed using conventional method
Mist is dry, obtains mixture C；
Wherein, 10 are maintained at using the pH that water body is adjusted in acetic acid and sodium bicarbonate in the decoction process；
4) dragon's blood, honeysuckle, motherwort and Cortex Phellodendri are weighed according to parts by weight, uses volume fraction for 70% after mixing
Ethyl alcohol conventionally carry out refluxing extraction three times, 30 minutes every time, be then combined with three times extracting solution carry out 200 mesh mistakes
Relative density is 1.18 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C, is then spray-dried, is obtained using conventional method
Mixture D；
5) mixture C obtained in step 3) is uniformly mixed with mixture D obtained in step 4), is sterilized, i.e.,
?；Described further include that pharmaceutically acceptable carrier and excipient is added and uses this field conventional preparation method after mixing
Preparation is made.
In the present embodiment, application of the Chinese medicine of the treatment gynaecological imflammation in preparation treatment gynaecological imflammation drug.
Embodiment 4
A kind of Chinese medicine for treating gynaecological imflammation, including below according to the raw material of parts by weight: 42 parts of Caulis Spatholobi, alpine yarrow 28
Part, 20 parts of field pennycress, 9 parts of dandelion, 16 parts of Radix Glycyrrhizae, 8 parts of dragon's blood, 12 parts of honeysuckle, 17 parts of motherwort, 6 parts of Cortex Phellodendri；Further include
Pharmaceutically acceptable carrier；By with Caulis Spatholobi, alpine yarrow, field pennycress, dandelion, Radix Glycyrrhizae, dragon's blood, honeysuckle, motherwort,
The plurality of Chinese raw material such as Cortex Phellodendri carries out reasonable compatibility, is conducive to improve the therapeutic effect to gynaecological imflammation.
In the present embodiment, the preparation method of the Chinese medicine of the treatment gynaecological imflammation, steps are as follows:
1) according to parts by weight weigh Caulis Spatholobi, alpine yarrow, field pennycress, dandelion and Radix Glycyrrhizae cleaned respectively with deionized water it is dry
Only, it is put into jointly after drying and carries out being crushed to 20 mesh into pulverizer, obtain mixture A；
2) water of 9 times of volumes will be added in mixture A obtained in step 1), then carried out using supersonic wave wall breaking technology
Ultrasonic treatment, obtains mixture B；The condition of the ultrasonic treatment is that ultrasonic power is 120W, ultrasonic time 30min；The water
For aseptic deionized water；By ultrasonic treatment, be conducive to water enter raw material intracellular progress sufficiently dilution it is effective abundant, effectively
The extraction effect to raw material is improved, while being conducive to the subsequent decoction to medicinal material；
3) mixture B obtained in step 2) is conventionally subjected to decoction 3h, decoction liquor is then subjected to 200 mesh
Then the medicinal extract that relative density is 1.13 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C is sprayed using conventional method
Mist is dry, obtains mixture C；
Wherein, 9 are maintained at using the pH that water body is adjusted in acetic acid and sodium bicarbonate in the decoction process；
4) dragon's blood, honeysuckle, motherwort and Cortex Phellodendri are weighed according to parts by weight, uses volume fraction for 70% after mixing
Ethyl alcohol conventionally carry out refluxing extraction three times, 30 minutes every time, be then combined with three times extracting solution carry out 200 mesh mistakes
Relative density is 1.18 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C, is then spray-dried, is obtained using conventional method
Mixture D；
5) mixture C obtained in step 3) is uniformly mixed with mixture D obtained in step 4), is sterilized, i.e.,
?；Described further include that pharmaceutically acceptable carrier (such as deionized water) is added and uses this field conventional formulation after mixing
Preparation is made in method.
In the present embodiment, application of the Chinese medicine of the treatment gynaecological imflammation in preparation treatment gynaecological imflammation drug.
Embodiment 5
A kind of Chinese medicine for treating gynaecological imflammation, including below according to the raw material of parts by weight: 38 parts of Caulis Spatholobi, alpine yarrow 25
Part, 18 parts of field pennycress, 8 parts of dandelion, 14 parts of Radix Glycyrrhizae, 7 parts of dragon's blood, 11 parts of honeysuckle, 15 parts of motherwort, 5 parts of Cortex Phellodendri；Further include
Pharmaceutically acceptable carrier；By with Caulis Spatholobi, alpine yarrow, field pennycress, dandelion, Radix Glycyrrhizae, dragon's blood, honeysuckle, motherwort,
The plurality of Chinese raw material such as Cortex Phellodendri carries out reasonable compatibility, is conducive to improve the therapeutic effect to gynaecological imflammation.
In the present embodiment, the preparation method of the Chinese medicine of the treatment gynaecological imflammation, steps are as follows:
1) according to parts by weight weigh Caulis Spatholobi, alpine yarrow, field pennycress, dandelion and Radix Glycyrrhizae cleaned respectively with deionized water it is dry
Only, it is put into jointly after drying and carries out being crushed to 20 mesh into pulverizer, obtain mixture A；
2) water of 9 times of volumes will be added in mixture A obtained in step 1), then carried out using supersonic wave wall breaking technology
Ultrasonic treatment, obtains mixture B；The condition of the ultrasonic treatment is that ultrasonic power is 120W, ultrasonic time 30min；The water
For aseptic deionized water or distilled water or pure water；By ultrasonic treatment, is conducive to water and enters the intracellular progress of raw material sufficiently
Dilution is effectively abundant, effectively increases the extraction effect to raw material, while being conducive to the subsequent decoction to medicinal material；
3) mixture B obtained in step 2) is conventionally subjected to decoction 3h, decoction liquor is then subjected to 200 mesh
Then the medicinal extract that relative density is 1.13 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C is sprayed using conventional method
Mist is dry, obtains mixture C；
Wherein, 9 are maintained at using the pH that water body is adjusted in acetic acid and sodium bicarbonate in the decoction process；
4) dragon's blood, honeysuckle, motherwort and Cortex Phellodendri are weighed according to parts by weight, uses volume fraction for 70% after mixing
Ethyl alcohol conventionally carry out refluxing extraction three times, 30 minutes every time, be then combined with three times extracting solution carry out 200 mesh mistakes
Relative density is 1.18 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C, is then spray-dried, is obtained using conventional method
Mixture D；
5) mixture C obtained in step 3) is uniformly mixed with mixture D obtained in step 4), is sterilized, i.e.,
?；Described further include that deionized water is added and preparation is made using this field conventional preparation method after mixing.
In the present embodiment, application of the Chinese medicine of the treatment gynaecological imflammation in preparation treatment gynaecological imflammation drug.
Comparative example 1
Compared with Example 5, Caulis Spatholobi and alpine yarrow are free of, other are same as Example 5.
Comparative example 2
Compared with Example 5, field pennycress is free of, other are same as Example 5.
Comparative example 3
Compared with Example 5, Caulis Spatholobi, alpine yarrow and field pennycress are free of, other are same as Example 5.
Comparative example 4
In the prior art, commercially available ' Qianjin ' capsule to treat ganopathy.
Performance test
One, long-term toxicity test for animals
To the Chinese medicine of the treatment gynaecological imflammation of embodiment 1-5 preparation, with the standard of 10mg/g rat body weight for rat 6 months
Long term administration, the general activity after observing big raticide, wherein the state of mind, hair, excrement etc. are showed no obvious abnormalities；To liver,
Renal function index, which is showed no, to be significantly affected；Total protein in animal blood serum when off-test, albumin, alkaline phosphatase content with
Control group compares no significant difference；ECG examination is no abnormal；Each main organs visual inspection has no obvious enlargement, fills
The morphological changes of various tissue components such as blood, necrosis；The weight coefficient of the organs such as the heart, liver, spleen, lung, kidney, thymus gland, adrenal gland and control group phase
Than no significant difference；Histopathologic examination is showed no exception.These results suggest that the present invention is safer, in institute's amount of reagent model
Enclose interior no obvious toxic-side effects.
Two, performance test
Bacteriostasis property detection is carried out to the Chinese medicine of the treatment gynaecological imflammation of the preparation of embodiment 1-5 and comparative example 1-4, specifically
Be using bacterial strain (including Candida albicans ATCC10231, Escherichia coli 8099, staphylococcus aureus ATCC6538, the 8th generation,
There is provided by China Committee for Culture Collection of Microorganisms's common micro-organisms center) it is diluted to bacteria suspension with 0.03mo1/LPBS,
The Chinese medicine of the preparation of embodiment 1-5 and comparative example 1-4, which is separately added into deionized water, is made washing for the 0.8g/L containing crude drug amount simultaneously
Liquid, test are pressed C4 progress bacteriostatic tests of GB15979-2002 Disposable Sanitary Accessory sanitary standard, are divided in bacteriostatic test
Washing lotion prepared by Chinese medicine not with the preparation of embodiment 1-5 and comparative example 1-4 makees stoste, bacterial strain (including Candida albicans
ATCC10231, Escherichia coli 8099, staphylococcus aureus ATCC6538) effect 15min, test weight under the conditions of 20 ± 2 DEG C
3 times multiple, as shown in table 1-3, antibacterial circle diameter size can intuitively indicate fungistatic effect to specific test result.
Chinese medicine prepared by the present invention is to Candida albicans, Escherichia coli and the In Vitro Bacteriostasis of staphylococcus aureus effect point
It is not listed in table 1-3, by table 1-3 it is found that Chinese medicine prepared by the present invention has good bacteriostasis.From embodiment 5 and comparative example 1
Data comparison in as can be seen that the present invention can effectively improve fungistatic effect by addition Caulis Spatholobi and alpine yarrow, it is especially right
Candida albicans has excellent fungistatic effect；Add from can be seen that the present invention in the data comparison of embodiment 5 and comparative example 2
Add field pennycress, fungistatic effect can be effectively improved, especially there is excellent fungistatic effect to Candida albicans；From embodiment 5 with
In the data comparison of comparative example 4 as can be seen that compared with commercial product, the present invention passes through Caulis Spatholobi, alpine yarrow and field pennycress phase
Mutually cooperation, can effectively improve fungistatic effect, especially have excellent fungistatic effect to Candida albicans, to Candida albicans
Fungistatic effect is improved more than 5%.
In addition, as can be seen that the present invention passes through Caulis Spatholobi, alpine yarrow from the data comparison of embodiment 5 and comparative example 1-4
It cooperates with field pennycress, plays synergistic effect, fungistatic effect can be effectively improved, especially have to Candida albicans
There is excellent fungistatic effect.
Bacteriostasis testing result table of the table 1 to Candida albicans
Bacteriostasis testing result table of the table 2 to Escherichia coli
Bacteriostasis testing result table of the table 3 to staphylococcus aureus
Three, clinical test
1, Yan, 38 years old, recent underbelly pain, yellowish leukorrhea amount was more, and out of strength with the whole body, menstrual period lower abdomen falling inflation is obvious, more through measuring,
Color is dark red block, examines as chronic pelvic inflammatory disease, was once treated with western medicine antibiotics, but ineffective and recurrent exerbation, takes the present invention
The medicament of preparation 2 months, symptom is substantially reduced, continues to take 2 months, and symptom and sign disappear, and follow-up half a year is without recurrence.
2, Zhang, female 28 years old, frequent abdominal pain after giving birth to suffered from cervicitis, takes medicament prepared by the present invention 3 months,
Symptom is substantially reduced, continues to take 2 months, and abdominal pain disappears, and condition, follow-up half a year is without recurrence.
3, Lee, 45 years old, conscious grade fever, lower abdomen falling inflation pain, leukorrhea amount increased significantly in the recent period, purulence band blood,
There is peculiar smell, gynecologial examination is diagnosed as endometritis, takes medicament prepared by the present invention 3 months, and symptom is substantially reduced, continues to take
With 3 months, symptom was completely disappeared, recovery from illness.
As can be seen that Chinese medicine compound prescription prepared by the present invention has good fungistatic effect from result above, can be used for controlling
Gynaecological imflammation is treated, by more with Caulis Spatholobi, alpine yarrow, field pennycress, dandelion, Radix Glycyrrhizae, dragon's blood, honeysuckle, motherwort, Cortex Phellodendri etc.
Kind Chinese medicine material carries out reasonable compatibility, is conducive to improve the therapeutic effect to gynaecological imflammation；Due to being former using plurality of Chinese
Material is prepared, and to the Small side effects of human body, and is not easy to keep body bacterial resistance occurred, has been effectively ensured to gynaecology
The therapeutic effect of inflammation, avoid using broad-spectrum antibiotic therapy gynaecological imflammation easily lead to body it is bacterial resistance occurred and gradually
Reduce the drawbacks of therapeutic effect easily generates side effect to body.
Present invention has the advantages that the present invention is cooperated by Caulis Spatholobi, alpine yarrow and field pennycress, while assisting ultrasonic
Processing plays synergistic effect, can effectively improve fungistatic effect, especially has to Candida albicans excellent antibacterial
Effect, solve using broad-spectrum antibiotic therapy gynaecological imflammation easily lead to body it is bacterial resistance occurred and gradually decrease treatment effect
Fruit easily leads to the problem of side effect to body；By with Caulis Spatholobi, alpine yarrow, field pennycress, dandelion, Radix Glycyrrhizae, dragon's blood, gold and silver
The plurality of Chinese raw material such as flower, motherwort, Cortex Phellodendri carries out reasonable compatibility, is conducive to improve the therapeutic effect to gynaecological imflammation, by
Then it is prepared using plurality of Chinese raw material, to the Small side effects of human body, and is not easy to keep body bacterial resistance occurred,
It has been effectively ensured to the therapeutic effect to gynaecological imflammation, has avoided that easily lead to body using broad-spectrum antibiotic therapy gynaecological imflammation thin
Bacterium develops drug resistance and gradually decreases the drawbacks of therapeutic effect easily generates side effect to body；Also by ultrasonic treatment, be conducive to
The intracellular progress sufficiently dilution that water enters raw material is effectively abundant, effectively increases the extraction effect to raw material, is conducive to simultaneously
The subsequent decoction to medicinal material；The present invention uses plurality of Chinese compatibility, not only has good fungistatic effect, also exempts to human body
Epidemic disease system has good opsonic action, effectively increases body to the immunocompetence of bacterium, has a vast market foreground.
Better embodiment of the invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be without departing from the purpose of the present invention
Various changes can be made.There is no necessity and possibility to exhaust all the enbodiments.And it thus amplifies out apparent
Variation or variation be still in the protection scope of this invention.
Claims (10)
1. a kind of Chinese medicine for treating gynaecological imflammation, which is characterized in that including below according to the raw material of parts by weight: Caulis Spatholobi 30-46
Part, 20-30 parts of alpine yarrow, 15-21 parts of field pennycress, 6-10 parts of dandelion, 10-18 parts of Radix Glycyrrhizae, 5-9 parts of dragon's blood, honeysuckle 8-14
Part, 12-18 parts of motherwort, 3-7 parts of Cortex Phellodendri.
2. the Chinese medicine for the treatment of gynaecological imflammation according to claim 1, which is characterized in that including below according to the original of parts by weight
Material: 34-42 parts of Caulis Spatholobi, 22-28 parts of alpine yarrow, 16-20 parts of field pennycress, 7-9 parts of dandelion, 12-16 parts of Radix Glycyrrhizae, dragon's blood 6-8
Part, 10-12 parts of honeysuckle, 13-17 parts of motherwort, 4-6 parts of Cortex Phellodendri.
3. the Chinese medicine for the treatment of gynaecological imflammation according to claim 1 or 2, which is characterized in that including below according to parts by weight
Raw material: 38 parts of Caulis Spatholobi, 25 parts of alpine yarrow, 18 parts of field pennycress, 8 parts of dandelion, 14 parts of Radix Glycyrrhizae, 7 parts of dragon's blood, honeysuckle 11
Part, 15 parts of motherwort, 5 parts of Cortex Phellodendri.
4. the Chinese medicine for the treatment of gynaecological imflammation according to claim 3, which is characterized in that further include pharmaceutically acceptable load
Body and/or excipient.
5. a kind of preparation method of the Chinese medicine of the treatment gynaecological imflammation as described in claim 1-4 is any, which is characterized in that step
It is as follows:
1) Caulis Spatholobi, alpine yarrow, field pennycress, dandelion and Radix Glycyrrhizae is weighed according to parts by weight to be cleaned up with deionized water respectively,
It is put into jointly after drying and carries out being crushed to 20 mesh into pulverizer, obtain mixture A；
2) water of 6-12 times of volume will be added in mixture A obtained in step 1), then carried out using supersonic wave wall breaking technology
Ultrasonic treatment, obtains mixture B；
3) mixture B obtained in step 2) is conventionally subjected to decoction 3h, decoction liquor is then subjected to 200 mesh mistakes
The medicinal extract that relative density is 1.13 when filtering, then filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C, is then spray-dried, obtains mixture
C；
4) dragon's blood, honeysuckle, motherwort and Cortex Phellodendri are weighed according to parts by weight, use after mixing volume fraction for 70% second
Alcohol conventionally carries out refluxing extraction three times, 30 minutes every time, is then combined with extracting solution three times and carries out 200 mesh filterings, then
Relative density is 1.18 when filtrate being taken to carry out being concentrated under reduced pressure into 60 DEG C, is then spray-dried, obtains mixture D；
5) mixture C obtained in step 3) is uniformly mixed with mixture D obtained in step 4), sterilizing to get.
6. the preparation method of the Chinese medicine for the treatment of gynaecological imflammation according to claim 5, which is characterized in that in step 2), institute
It is 120W, ultrasonic time 30min that the condition for stating ultrasonic treatment, which is ultrasonic power,.
7. the preparation method of the Chinese medicine for the treatment of gynaecological imflammation according to claim 6, which is characterized in that in step 2), institute
Stating water is aseptic deionized water or distilled water or pure water.
8. the preparation method of the Chinese medicine for the treatment of gynaecological imflammation according to claim 7, which is characterized in that in step 3), institute
It states in decoction process and pH is adjusted and is maintained at 8-10 using acetic acid and sodium bicarbonate.
9. the preparation method of the Chinese medicine for the treatment of gynaecological imflammation according to claim 8, which is characterized in that in step 5), institute
State further includes that pharmaceutically acceptable carrier and/or excipient is added and uses this field conventional preparation method system after mixing
At preparation.
10. a kind of Chinese medicine of the treatment gynaecological imflammation as described in claim 1-4 is any is in preparation treatment gynaecological imflammation drug
Application.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110559408A (en) * | 2019-09-30 | 2019-12-13 | 深圳仟枝生物科技股份有限公司 | ozone disinfecting, antibacterial and stasis-removing ointment for gynecology and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110559408A (en) * | 2019-09-30 | 2019-12-13 | 深圳仟枝生物科技股份有限公司 | ozone disinfecting, antibacterial and stasis-removing ointment for gynecology and preparation method thereof |
| CN110559408B (en) * | 2019-09-30 | 2023-08-22 | 深圳仟枝生物科技股份有限公司 | Gynecological ozone toxin-removing antibacterial stasis-removing paste and preparation method thereof |
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Effective date of registration: 20190215 Address after: 273200 No. 92 Sicheng Sihe Road, Sishui County, Jining City, Shandong Province Applicant after: Sishui County Hospital of Traditional Chinese Medicine Address before: 273200 No. 83 Health Road, Sishui County, Jining City, Shandong Province Applicant before: Sishui People's Hospital |
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Application publication date: 20190122 |