CN105944012A

CN105944012A - Traditional Chinese medicinal composition for treating pelvic inflammatory diseases and preparation method of traditional Chinese medicinal composition

Info

Publication number: CN105944012A
Application number: CN201610306556.2A
Authority: CN
Inventors: 曾定元; 肖萍; 王虹; 王麟; 李茜西; 吴秀芬; 王鑫丹; 贺红英
Original assignee: Liuzhou Maternity and Child Healthcare Hospital
Current assignee: Liuzhou Maternity and Child Healthcare Hospital
Priority date: 2016-05-11
Filing date: 2016-05-11
Publication date: 2016-09-21
Anticipated expiration: 2036-05-11
Also published as: CN105944012B

Abstract

The invention relates to a traditional Chinese medicinal composition for treating pelvic inflammatory diseases and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: herba patriniae, cortex phellodendri, herba taraxaci, fructus forsythia, radix paeoniae rubra, honeysuckle flowers, radix salviae miltiorrhizae, radix angelicae sinensis, flos carthami, peach kernel, rhizoma curcumae, rhizoma sparganii, spina gleditsiae, rhizoma smilacis glabrae, flos chrysanthemi indici, fructus cnidii, cortex dictamni, coix seeds, caulis spatholobi, herba leonuri, radix rubiae and liquorice root. The traditional Chinese medicinal composition provided by the invention has functions of clearing heat and diminishing inflammation, promoting blood circulation and removing stasis; and the entire prescription is strong in efficacy, and the prescription is conducive to circulation of pelvic blood and dredging of meridians and beneficial for improvement of metabolism and enhancement of an immunity function, so that purposes of diminishing inflammation and curing the diseases are achieved.

Description

A kind of Chinese medicine composition treating pelvic inflammatory disease and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition treating pelvic inflammatory disease and preparation side thereof Method.

Background technology

Pelvic inflammatory disease disease (PID) is common clinical, frequently-occurring disease, and reproductive tract infection on genus, including intrauterine Film inflammation, salpingitis, tubo-ovarian abscess, inflammation of pelvic connective tissue and pelvioperitonitis etc..Pelvic inflammatory disease disease For doctor trained in Western medicine name of disease, Chinese medical book is without the name of disease of pelvic inflammatory disease disease, according to its clinical manifestation, can belong to the traditional Chinese medical science " woman People suffers from abdominal pain ", " abdominal mass ", " invasion of the blood-chamber by heat ", the category such as " leukorrheal diseases ".Its sequela such as pelvic pain, ectopic pregnancy and infertility Etc. the quality of life having had a strong impact on numerous women.Morbidity has the trend increased year by year.

Doctor trained in Western medicine is treated mainly for pathogen, and medication is based on antibiotic, to killing pathogen determined curative effect, but right A series of pathology damage effects that pathogen is caused are inconspicuous, not notable to improving clinical symptoms effect, so that state of an illness fashion Time bad, more, and prolonged and repeated application antibiotic the most likely produces drug resistance to delay difficulty, makes Resistant strain increase, there is also and answers Send out and the problem of adverse effect.Chinese medicine pelvic inflammatory disease disease has certain curative effect, correlational study to show, anti- Raw element combines the curative effect of tcm treatment according to syndrome differentiation treatment primary disease and uses antibiotic person higher than simple, can shorten with quick symptom relief The course for the treatment of.

Women not passing through, gestation and lower abdomen or few abdomen pain occurred during puerperal, the most then pain connects waist sacrum person, is referred to as " woman People suffers from abdominal pain ".The pelvic inflammatory disease disease of doctor trained in Western medicine can refer to the dialectical treatment of primary disease.The cause of disease mostly is through row puerperal, Yu Xuewei To the greatest extent, experience damp and hot heresy, or intemperate sexual intercourse, or pudendum is unclean, damp and hot knot of fighting with blood, stagnation of blood stasis in CHONG and REN meridians: or host retention of damp-heat in the interior, flow Pouring down Jiao, block QI and blood, the long-pending punching of the stasis of blood is appointed, vessels of the uterus hematogenous blockage, stagnation of QI and blood may bring about pain, so that stomachache.

Treatment is with removing damp-heat, and blood-activating analgetic is principle, selects Chinese medicine conditioning targetedly, accomplishes treating both the principal and secondary aspects of a disease, obtaining While obtaining optimal clinical curative effect, reduce Patients on Recurrence rate.

Summary of the invention

It is an object of the invention to provide a kind of Chinese medicine composition treating pelvic inflammatory disease；

It is a further object of the present invention to provide the preparation method of a kind of Chinese medicine composition treating pelvic inflammatory disease.

It is an object of the invention to by following technical scheme realization:

The Chinese medicine composition for the treatment of pelvic inflammatory disease of the present invention, is to be prepared from by the raw material of Chinese medicine of following weight portion :

Herba Patriniae 20-50 part, Cortex Phellodendri 5-20 part, Herba Taraxaci 10-30 part, Fructus Forsythiae 10-30 part, Radix Paeoniae Rubra 10-30 part, Flos Lonicerae 10- 30 parts, Radix Salviae Miltiorrhizae 5-20 part, Radix Angelicae Sinensis 5-20 part, Flos Carthami 2-10 part, Semen Persicae 5-20 part, Rhizoma Curcumae 10-30 part, Rhizoma Sparganii 10-30 part, Fructus Gleditsia Thorn 10-30 part, Rhizoma Smilacis Glabrae 10-30 part, Flos Chrysanthemi Indici 10-30 part, Fructus Cnidii 5-20 part, Cortex Dictamni 10-30 part, Semen Coicis 20-50 Part, Caulis Spatholobi 20-50 part, Herba Leonuri 10-30 part, Radix Rubiae 10-30 part, Radix Glycyrrhizae 2-10 part.

Preferably, it is to be prepared from by the raw material of Chinese medicine of following weight portion:

Herba Patriniae 30-40 part, Cortex Phellodendri 8-15 part, Herba Taraxaci 15-20 part, Fructus Forsythiae 15-20 part, Radix Paeoniae Rubra 15-20 part, Flos Lonicerae 15- 20 parts, Radix Salviae Miltiorrhizae 8-15 part, Radix Angelicae Sinensis 8-15 part, Flos Carthami 4-6 part, Semen Persicae 8-15 part, Rhizoma Curcumae 15-20 part, Rhizoma Sparganii 15-20 part, Fructus Gleditsia Thorn 15-20 part, Rhizoma Smilacis Glabrae 15-20 part, Flos Chrysanthemi Indici 15-20 part, Fructus Cnidii 8-15 part, Cortex Dictamni 15-20 part, Semen Coicis 30-40 Part, Caulis Spatholobi 30-40 part, Herba Leonuri 15-20 part, Radix Rubiae 15-20 part, Radix Glycyrrhizae 4-6 part.

The following is the crude drug source of Chinese medicine preparation of the present invention:

Herba Patriniae, for Herba Patriniae section plant Hemerocallis citrina Baroni dragon bud Patrinia scabiosaefolia Fisch. ex Link., spends in vain Herba Patriniae (bitter vegetarian) P. villosa (Thunb.) Juss., with root stock and root, all herbal medicine.[nature and flavor] are pungent, bitter, cool.[return Warp] enter stomach, large intestine, Liver Channel.[function cures mainly] heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.Swollen for acute appendicitis, lung abscess and carbuncle sore Poison, the stagnant caused chest and abdomen pain of the excess-heat stasis of blood, puerperal the disease such as the stagnant stomachache of the stasis of blood.

Cortex Phellodendri, for rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri The dry bark of Phellodendron amurense Rupr..[nature and flavor] are bitter, cold.[return through] returns kidney, bladder warp.[function master Control] heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, tinea pedis, flaccidity { wards off }, hectic fever due to YIN-deficiency labor Heat, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.

Herba Taraxaci, for feverfew Herba Taraxaci Taraxacum mongolicum Hand.-Mazz., alkali ground Herba Taraxaci Taraxacum sinicum Kitag. or belong to the dry herb of several plants together.[nature and flavor] are bitter, sweet, cold.[return through] returns liver, stomach Warp.[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung Carbuncle, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Fructus Forsythiae, for the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.[nature and flavor] Hardship, is slightly cold.[return through] returns lung, the heart, small intestine meridian.[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, Erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warm is joined the army, high hot excessive thirst, and coma sends out speckle, pyretic stranguria urine retention.

Radix Paeoniae Rubra, for ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii The dry root of Lynch.[nature and flavor] are bitter, are slightly cold.[return through] returns Liver Channel.[function cures mainly] clearing away heat and cooling blood, eliminating stasis to stop pain.For temperature Poison sends out speckle, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.

Flos Lonicerae, for caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera Hypoglauca Miq., Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera The flower that the dry flower of dasystyla Rehd. or band are just opened.[nature and flavor] are sweet, cold.[return through] returns lung, the heart, stomach warp.[function master Control] heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.

Radix Salviae Miltiorrhizae, for the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge..[nature and flavor] Hardship, is slightly cold.[return through] GUIXIN, Liver Channel.[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, warp Closing dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia；Hepatosplenomegaly, angina pectoris.

Radix Angelicae Sinensis, for the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.[nature and flavor] Sweet, acrid, warm.[return through] returns liver, the heart, spleen channel.[function cures mainly] replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Wither for blood deficiency Huang, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Wine Radix Angelicae Sinensis promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Flos Carthami, for the dry flower of feverfew Flos Carthami Carthamus tinctorius L..[nature and flavor] are pungent, temperature.[return through] GUIXIN, Liver Channel.[function cures mainly] promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, fall and flutter damage Wound, skin infection swells and ache.

Semen Persicae, for rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) dry mature seed of Franch..[nature and flavor] bitter, sweet, flat.[return through] GUIXIN, liver, large intestine channel.[function cures mainly] lives Blood and dissolving stasis, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea, abdominal mass mass in the abdomen, injury from falling down, dryness of the intestine constipation.

Rhizoma Curcumae, for zingiberaceous plant Rhizoma Curcumae Curcuma phaeocaulis Val., Guangxi zedoary Curcuma Kwangsiensis S. G.Lee et C. F. Liang or RADIX CURCUMAE Curcuma wenyujin Y.H. Chen et C. The dry rhizome of Ling.Nature and flavor] pungent, bitter, temperature.[return through] returns liver, spleen channel.[function cures mainly] circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain；Early cervical carcinoma.

Rhizoma Sparganii, for the dried pieces of Sparganiaceae plant rhizoma scirpi Sparganium stoloniferum Buch.-Ham. Stem.[nature and flavor] are pungent, bitter, flat.[return through] returns liver, spleen channel.[function cures mainly] removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, the stasis of blood Blood amenorrhea, food stagnation distending pain.

Spina Gleditsiae, for the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..[nature and flavor] are pungent, temperature. [return through] returns liver, stomach warp.[function cures mainly] detumescence poison holding, evacuation of pus, parasite killing.For carbuncle from the beginning of or difficulty in discharging of pus；External treatment scabies Leprosy.

Rhizoma Smilacis Glabrae, for the dry rhizome of liliaceous plant smilacis glabra Smilax glabra Roxb..[nature and flavor] are sweet, light, Flat.[return through] returns liver, stomach warp.[function cures mainly] dehumidifies, removing toxic substances, easing joint movement.For damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, Limbs contracture caused by scabies, syphilis and mercurialism, bones and muscles pain.

Dry capitulum for feverfew Herba Dendranthematis indici Chrysanthemum indicum L..[nature and flavor] are bitter, pungent, micro- Cold.[return through] returns liver, heart channel.[function cures mainly] heat-clearing and toxic substances removing.For furuncle carbuncle, conjunctival congestion and swelling pain, dizziness of having a headache.

Herba Leonuri, for the fresh of labiate Herba Leonuri Leonurus japonicus Houtt. or top dryly Point.[nature and flavor] are bitter, pungent, are slightly cold.[return through] returns liver, pericardium channel.[function cures mainly] promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menstruation not Adjust, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria；Oedema due to nephritis.

Radix Rubiae, for the dry root and rhizome of Maguireothamnus speciosus Radix Rubiae Rubia cordifolia L..[nature and flavor] are bitter, cold. [return through] returns Liver Channel.[function cures mainly] removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow.For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, the amenorrhea stasis of blood Resistance, arthralgia, tumbling and swelling.

Radix Glycyrrhizae, for glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or the dry root of Glycyrrhiza glabra L. Glycyrrhiza glabra L..[nature and flavor] are sweet, flat.[return through] returns The heart, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For spleen Insufficiency of stomach is weak, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong Property.

Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method is Use water to carry or the ethanol extraction of 40-80% concentration expressed in percentage by volume is prepared from.Concrete preparation method is as follows:

Scheme one: take whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to 6-12 times of medical material gross weight, Extraction time is 1-3 hour every time, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is 1.15-1.20 Clear paste, obtain active component.

Scheme two: take whole medical material, uses 40-80% alcohol reflux 2-3 time after mixing, and each ethanol consumption is medical material total amount 4-10 times, extraction time is 1-4 hour, united extraction liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is 1.15-1.20 clear paste, obtain active component.

Scheme three: take whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-of medical material gross weight 12 times, each extraction time is 1-3 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is The clear paste of 1.15-1.20, adds ethanol, and making alcohol content is 40-70%, stands 12-24 hour, filters, and filtrate is concentrated into 70-80 DEG C time relative density be the extractum of 1.10-1.25, obtain active component.

The Chinese medicine composition for the treatment of pelvic inflammatory disease of the present invention, it is also possible to pharmaceutically acceptable carrier Coordinate, make various oral formulations, such as tablet, capsule, oral liquid, syrup, mixture etc..

The pharmaceutically acceptable carrier of the present invention includes but not limited to following:

Oral formulations:

Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc..

Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc..

Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc..

Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc..

Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, vegetable oil etc..

Correctives: sucrose, monosaccharide, aromatic etc..

Preservative: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc..

Method 1: tablet

Taking one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into this routinely Invention tablet.

Above-mentioned tablet is commonly used adjuvant and is included one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.

Method 2: capsule

Taking one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into routinely Capsule of the present invention.

Above-mentioned capsule is commonly used adjuvant and is included one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.

Method 3: syrup

Taking one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into routinely Syrup of the present invention.

Above-mentioned syrup is commonly used adjuvant and is included one of correctives, preservative, cosolvent or whole.

Method 4: mixture

Taking one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into this routinely Invention mixture.

Above-mentioned mixture is commonly used adjuvant and is included one of correctives, preservative or whole.

Method 5: oral liquid

Take one of scheme one to scheme three gained active component, dissolve after-purification, concentration, add oral liquid and commonly use adjuvant, by often Rule production method is prepared into oral liquid of the present invention.

Above-mentioned oral liquid is commonly used adjuvant and is included one of correctives, preservative, cosolvent or whole.

The applicant on the basis of research tradition tcm syndrome differentiation and treatment with reference to modern pharmacological research achievement, through for many years Test, screens multiple formulations, have found the Chinese medicine formula that can effectively treat pelvic inflammatory disease, Herba Patriniae, Pu in side Herba Taraxaci, Fructus Forsythiae, Flos Lonicerae, Flos Chrysanthemi Indici heat-clearing and toxic substances removing, dispersing swelling and dissipating binds；Flos Carthami, Semen Persicae, Radix Angelicae Sinensis, Caulis Spatholobi blood circulation promoting and blood stasis dispelling stimulate the menstrual flow；Three Rib, Rhizoma Curcumae, Radix Salviae Miltiorrhizae removing blood stasis, promoting the circulation of QI to relieve pain；Radix Paeoniae Rubra, Radix Rubiae clearing away heat and cooling blood, stasis-dispelling and pain-killing；Herba Leonuri blood circulation promoting and blood stasis dispelling, diuresis Detumescence；The heat of the clear part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels of Cortex Phellodendri；Rhizoma Smilacis Glabrae, Semen Coicis, Cortex Dictamni, Fructus Cnidii play removing damp-heat, the effect of diuretic evacuation of pus altogether；Radix Glycyrrhizae QI invigorating and in, coordinating the actions of various ingredients in a prescription.Full side has effect of heat clearing and inflammation relieving, blood circulation promoting and blood stasis dispelling, and whole prescription effect is powerful, contributes to pelvic cavity The flowing of blood, the dredging of meridians, contribute to the metabolic vigorous and enhancing of immune function, to reach the mesh that antiinflammatory is recovered 's.

A kind of Chinese medicine composition treating pelvic inflammatory disease that the present invention provides has the advantage that

1, the composite preparation that the present invention provides is safe and effective, and full side has effect of heat clearing and inflammation relieving, blood circulation promoting and blood stasis dispelling, whole prescription Effect is powerful, contributes to the flowing of pelvic cavity blood, the dredging of meridians, contributes to the metabolic vigorous and increasing of immune function By force, to reach the purpose that antiinflammatory is recovered.

2, clinical tests prove that, after traditional Chinese medicine composition for treating of the present invention, total to pelvic inflammatory disease patient Effective percentage is 93.3%.

3, the Chinese medicinal composition preparation that the present invention provides, scientific formulation is reasonable, and technique is simple, in good taste, low cost.

Detailed description of the invention

The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustrating The present invention rather than limitation of the present invention.The simple modifications that the present invention is carried out by the essence according to the present invention broadly falls into the present invention Claimed scope.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution Volume ratio.

Embodiment 1 tablet

Weigh Herba Patriniae 20g, Cortex Phellodendri 5g, Herba Taraxaci 10g part, Fructus Forsythiae 10g, Radix Paeoniae Rubra 10g, Flos Lonicerae 10g, Radix Salviae Miltiorrhizae 5g, Radix Angelicae Sinensis 5g, Flos Carthami 2g, Semen Persicae 5g, Rhizoma Curcumae 10g, Rhizoma Sparganii 10g, Spina Gleditsiae 10g, Rhizoma Smilacis Glabrae 10g, Flos Chrysanthemi Indici 10g, Fructus Cnidii 5g, Cortex Dictamni 10g, Semen Coicis 20g, Caulis Spatholobi 20g, Herba Leonuri 10g, Radix Rubiae 10g, Radix Glycyrrhizae 2g.Extracting in water 3 times, three times amount of water is respectively 12 times of medical material gross weight, 8 times, 6 times, three extraction times are respectively 3 hours, 2 hours, 1 hour, united extraction liquid, filter, When filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, adds supplementary product starch, ethanol, Pulvis Talci, prepares tablet.

Embodiment 2 tablet

Weigh Herba Patriniae 50g, Cortex Phellodendri 20g, Herba Taraxaci 30g part, Fructus Forsythiae 30g, Radix Paeoniae Rubra 30g, Flos Lonicerae 30g, Radix Salviae Miltiorrhizae 20g, Radix Angelicae Sinensis 20g, Flos Carthami 10g, Semen Persicae 20g, Rhizoma Curcumae 30g, Rhizoma Sparganii 30g, Spina Gleditsiae 30g, Rhizoma Smilacis Glabrae 30g, Flos Chrysanthemi Indici 30g, Fructus Cnidii 20g, Cortex Dictamni 30g, Semen Coicis 50g, Caulis Spatholobi 50g, Herba Leonuri 30g, Radix Rubiae 30g, Radix Glycyrrhizae 10g.With 40% alcohol reflux 3 times, Ethanol consumption is respectively 10 times of medical material total amount, 8 times, 4 times every time, and 3 hours, 2 hours, 1 hour respectively extraction time, merging carries Taking liquid, filter, when filtrate concentrates 60 DEG C, relative density is the extractum of 1.25, adds supplementary product starch, ethanol, Pulvis Talci, prepares sheet Agent.

Embodiment 3 granule

Weigh Herba Patriniae 30g, Cortex Phellodendri 8g, Herba Taraxaci 15g part, Fructus Forsythiae 15g, Radix Paeoniae Rubra 15g, Flos Lonicerae 15g, Radix Salviae Miltiorrhizae 8g, Radix Angelicae Sinensis 8g, Flos Carthami 4g, Semen Persicae 8g, Rhizoma Curcumae 15g, Rhizoma Sparganii 15g, Spina Gleditsiae 15g, Rhizoma Smilacis Glabrae 15g, Flos Chrysanthemi Indici 15g, Fructus Cnidii 8g, Cortex Dictamni 15g, Semen Coicis 30g, Caulis Spatholobi 30g, Herba Leonuri 15g, Radix Rubiae 15g, Radix Glycyrrhizae 4g.Extracting in water 3 times, three amount of water phases respectively When in 12 times, 8 times, 6 times of medical material gross weight, each extraction time is distinguished 3 hours, 2 hours, 1 hour, united extraction liquid, filter Crossing, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, adds ethanol, and making alcohol content is 40%, stands 24 hours, filter Crossing, it is the extractum of 1.10 that filtrate is concentrated into relative density when filtrate is concentrated into 70 DEG C, adds starch, dextrin, pelletizes, is dried, whole Grain and get final product.

Embodiment 4 capsule

Weigh Herba Patriniae 40g, Cortex Phellodendri 15g, Herba Taraxaci 20g part, Fructus Forsythiae 20g, Radix Paeoniae Rubra 20g, Flos Lonicerae 20g, Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 15g, Flos Carthami 6g, Semen Persicae 15g, Rhizoma Curcumae 20g, Rhizoma Sparganii 20g, Spina Gleditsiae 20g, Rhizoma Smilacis Glabrae 20g, Flos Chrysanthemi Indici 20g, Fructus Cnidii 15g, white Cortex Dictamni 20g, Semen Coicis 40g, Caulis Spatholobi 40g, Herba Leonuri 20g, Radix Rubiae 20g, Radix Glycyrrhizae 6g.By alcohol reflux 2 times, each second Determining alcohol is respectively 80%, 60%, and each ethanol consumption is respectively 10 times of medical material total amount, 8 times, extraction time be respectively 4 hours, 3 hours, united extraction liquid, to filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, adds adjuvant and form sediment in extractum Powder, ethanol, dextrin, magnesium stearate, make capsule according to a conventional method.

Embodiment 5 oral liquid

Weigh Herba Patriniae 25g, Cortex Phellodendri 8g, Herba Taraxaci 12g part, Fructus Forsythiae 18g, Radix Paeoniae Rubra 12g, Flos Lonicerae 20g, Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 12g, Flos Carthami 3g, Semen Persicae 15g, Rhizoma Curcumae 12g, Rhizoma Sparganii 12g, Spina Gleditsiae 15g, Rhizoma Smilacis Glabrae 10g, Flos Chrysanthemi Indici 20g, Fructus Cnidii 12g, white Cortex Dictamni 12g, Semen Coicis 25g, Caulis Spatholobi 30g, Herba Leonuri 15g, Radix Rubiae 18g, Radix Glycyrrhizae 5g.Extracting in water 2 times, twice amount of water divides Not Wei 10 times of medical material gross weight, 8 times, twice extraction time is respectively 2 hours, 1 hour, united extraction liquid, filter, filtrate is dense Being reduced to relative density when 80 DEG C is the extractum of 1.10, and in extractum, addition adjuvant mannitol, sorbic acid, water stir, subpackage, Prepare oral liquid.

Embodiment 6 granule

Weigh Herba Patriniae 35g, Cortex Phellodendri 12g, Herba Taraxaci 18g part, Fructus Forsythiae 20g, Radix Paeoniae Rubra 15g, Flos Lonicerae 25g, Radix Salviae Miltiorrhizae 10g, Radix Angelicae Sinensis 15g, Flos Carthami 7g, Semen Persicae 7g, Rhizoma Curcumae 23g, Rhizoma Sparganii 18g, Spina Gleditsiae 12g, Rhizoma Smilacis Glabrae 25g, Flos Chrysanthemi Indici 15g, Fructus Cnidii 18g, white Cortex Dictamni 23g, Semen Coicis 35g, Caulis Spatholobi 25g, Herba Leonuri 17g, Radix Rubiae 13g, Radix Glycyrrhizae 8g.Extracting in water 2 times, each amount of water divides Not being equivalent to 12 times of medical material gross weight, 10 times, each extraction time is respectively 3 hours, 2 hours, united extraction liquid, filters, It is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, adds ethanol, and making alcohol content is 70%, stands 12 hours, filters, When filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, adds starch, dextrin, pelletizes, is dried, granulate and get final product.

Embodiment 7 syrup

Weigh Herba Patriniae 45g, Cortex Phellodendri 6g, Herba Taraxaci 13g part, Fructus Forsythiae 23g, Radix Paeoniae Rubra 18g, Flos Lonicerae 28g, Radix Salviae Miltiorrhizae 12g, Radix Angelicae Sinensis 9g, Flos Carthami 3g, Semen Persicae 9g, Rhizoma Curcumae 28g, Rhizoma Sparganii 23g, Spina Gleditsiae 18g, Rhizoma Smilacis Glabrae 10g, Flos Chrysanthemi Indici 18g, Fructus Cnidii 7g, shaggy-fruited dittany Skin 28g, Semen Coicis 45g, Caulis Spatholobi 35g, Herba Leonuri 22g, Radix Rubiae 16g, Radix Glycyrrhizae 4g.Extracting in water 2 times, twice amount of water is respectively For 10 times, 8 times of medical material gross weight, twice extraction time is respectively 2 hours, 1 hour, united extraction liquid, filters, and filtrate concentrates It is the extractum of 1.10 to relative density when 80 DEG C.In extractum, addition syrup adjuvant sucrose, sorbic acid, water stir, system Obtain syrup.

Embodiment 8 mixture

Weigh Herba Patriniae 25g, Cortex Phellodendri 10g, Herba Taraxaci 23g part, Fructus Forsythiae 28g, Radix Paeoniae Rubra 12g, Flos Lonicerae 18g, Radix Salviae Miltiorrhizae 13g, Radix Angelicae Sinensis 17g, Flos Carthami 8g, Semen Persicae 18g, Rhizoma Curcumae 20g, Rhizoma Sparganii 15g, Spina Gleditsiae 30g, Rhizoma Smilacis Glabrae 15g, Flos Chrysanthemi Indici 25g, Fructus Cnidii 5g, white Cortex Dictamni 10g, Semen Coicis 40g, Caulis Spatholobi 30g, Herba Leonuri 15g, Radix Rubiae 20g, Radix Glycyrrhizae 5g.Extracting in water 3 times, three times amount of water divides Be not equivalent to 12 times of medical material gross weight, 8 times, 6 times, 3 hours, 2 hours, 1 hour respectively each extraction time, united extraction Liquid, filters, and filtrate is concentrated into 3 times that gross weight is medical material gross weight, fill, adds mixture adjuvant sucrose, ethyl ester, water, Pyrusussuriensis Acid stirs, and prepares mixture.

Embodiment 9 powder

Weigh Herba Patriniae 30g, Cortex Phellodendri 5g, Herba Taraxaci 30g part, Fructus Forsythiae 20g, Radix Paeoniae Rubra 15g, Flos Lonicerae 25g, Radix Salviae Miltiorrhizae 10g, Radix Angelicae Sinensis 15g, Flos Carthami 8g, Semen Persicae 15g, Rhizoma Curcumae 20g, Rhizoma Sparganii 15g, Spina Gleditsiae 25g, Rhizoma Smilacis Glabrae 20g, Flos Chrysanthemi Indici 30g, Fructus Cnidii 5g, white Cortex Dictamni 15g, Semen Coicis 40g, Caulis Spatholobi 20g, Herba Leonuri 12g, Radix Rubiae 25g, Radix Glycyrrhizae 5g.Pulverize, sieve, to obtain final product.

Clinical trial is summed up

1 basic document

Observe 89 example patients be the pelvic inflammatory disease patient that my institute accepts for medical treatment, all combine clinical manifestation and examination per vagina and B ultrasonic etc. are made a definite diagnosis.Age 21～50 years old, average (33.2 ± 2.8) year.The course of disease 3 months-4 years.Patient mainly shows as rectal tenesmus Bitterly, lifting pain, posterior fornix tenderness, palace body and attachment area tenderness etc., some patients has nauseating, dizzy, and heating is with weak Etc. symptom.B ultrasonic display pelvic hydrops 56 example, empyema 8 example.

2 Therapeutic Method

Give the embodiment of the present invention 2 tablet in treatment, each 4, be administered orally three times a day.7d is a course for the treatment of, the most sick according to patient Feelings can treat 2～3 courses for the treatment of as one sees fit.

3 curative effect judging standards

Effective: clinical symptom disappearance, leukocyte ＜ 10.0 × 10⁹/ L, inflammatory mass and pelvic cavity free fluid all disappear.

Effective: clinical symptoms has improvement in various degree, leukocyte ＜ 10.0 × 10⁹/ L, inflammatory mass and pelvic cavity are free Liquid has reduction in various degree.

Invalid: clinical symptoms is not improved, lab testing and ultrasound diagnosis index of correlation are all not improved.

Total effective rate is that obvious effective rate adds effective percentage.

4 the results are shown in Table 1.

Table 1 efficacy result

	Effective	Effectively	Invalid	Effective percentage (%)
					Curative effect	52	31	6	93.3

Clinical effectiveness shows: the present invention is 93.3% to the total effective rate of pelvic inflammatory disease patient, and result shows, the present invention has The curative effect of good treatment pelvic inflammatory disease.

Model case

Week XX, women, married, 33 years old.Main suit leucorrhea many abnormal flavour half a year, before half a year, started occur that leucorrhea amount is many, abnormal flavour, accompany lower abdomen Portion's pain, sexual anhedonia (feels conflict sense), and menstruation is not the drippingst clean, the leucorrhea band blood streak.B ultrasonic prompting pelvic hydrops, long-pending Liquid about 1.6cm, diagnoses pelvic inflammatory disease, gives the embodiment of the present invention 5 and treat, and after 5 days, hypogastralgia symptom is alleviated, in vain Ribbon amount reduces, and abnormal flavour substantially alleviates.Following the service is hypogastralgia disappearance after 8 days, and leucorrhea amount is normal, and abnormal flavour is light, and B ultrasonic display pelvic cavity is without long-pending Liquid.

X, female, 40 years old.Main suit: more than lower abdominal pain companion irregular vagina bleeding March.Patient's menstruation usually rule, before 3 months Conscious lower abdomen dull pain, accompanies irregular vagina bleeding, because subjective symptoms is relatively light, does not goes to see a doctor, and sensation stomachache increases the weight of subsequently, arrives Hospital admission, ultrasound diagnosis finds pelvic hydrops, is diagnosed as pelvic inflammatory disease.Give the embodiment of the present invention 8 after one week treatment, Hypogastralgia disappears, and after continual cure January, guides irregular bleeding transference cure, and check B ultrasonic pelvic cavity is long-pending to disappear.

Liu XX, 42 years old, female.Suffer from pelvic inflammatory disease before 3 years, but be transformed to pelvic cavity owing to not treating in time Inflammatory diseases sequela, main suit has hypogastric region pendant pain and lumbosacral region to ache, often after fatigue, sexual intercourse, aggravation before and after menstruation, and the moon Through a lot, show through ultrasound diagnosis: each visible shade, edge blurry at the adnexa of both sides, uterus, the distribution of luminous point, light belt is mixed and disorderly.Give The embodiment of the present invention 3 is treated, and after treating 3 days, the most bitterly, after 7 days, soreness of waist sense disappears lower abdomen, and the mental status is good, no longer has a sleepless night. After treating 15 days, returning institute's check, B ultrasonic display shade disappears.

Although, used general explanation, detailed description of the invention and test, the present invention made detailed retouching Stating, but on the basis of the present invention, can make some modifications or improvements it, this is apparent to those skilled in the art 's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed Scope.

Claims

1. the Chinese medicine composition treating pelvic inflammatory disease, it is characterised in that it is by the raw material of Chinese medicine system of following weight portion Standby: Herba Patriniae 20-50 part, Cortex Phellodendri 5-20 part, Herba Taraxaci 10-30 part, Fructus Forsythiae 10-30 part, Radix Paeoniae Rubra 10-30 part, gold silver Flower 10-30 part, Radix Salviae Miltiorrhizae 5-20 part, Radix Angelicae Sinensis 5-20 part, Flos Carthami 2-10 part, Semen Persicae 5-20 part, Rhizoma Curcumae 10-30 part, Rhizoma Sparganii 10-30 Part, Spina Gleditsiae 10-30 part, Rhizoma Smilacis Glabrae 10-30 part, Flos Chrysanthemi Indici 10-30 part, Fructus Cnidii 5-20 part, Cortex Dictamni 10-30 part, Semen Coicis Core 20-50 part, Caulis Spatholobi 20-50 part, Herba Leonuri 10-30 part, Radix Rubiae 10-30 part, Radix Glycyrrhizae 2-10 part.

2. the Chinese medicine composition treating pelvic inflammatory disease as claimed in claim 1, it is characterised in that it is as follows by including The raw material of Chinese medicine of weight portion is prepared from: Herba Patriniae 30-40 part, Cortex Phellodendri 8-15 part, Herba Taraxaci 15-20 part, Fructus Forsythiae 15-20 Part, Radix Paeoniae Rubra 15-20 part, Flos Lonicerae 15-20 part, Radix Salviae Miltiorrhizae 8-15 part, Radix Angelicae Sinensis 8-15 part, Flos Carthami 4-6 part, Semen Persicae 8-15 part, Rhizoma Curcumae 15-20 part, Rhizoma Sparganii 15-20 part, Spina Gleditsiae 15-20 part, Rhizoma Smilacis Glabrae 15-20 part, Flos Chrysanthemi Indici 15-20 part, Fructus Cnidii 8-15 part, white Cortex Dictamni 15-20 part, Semen Coicis 30-40 part, Caulis Spatholobi 30-40 part, Herba Leonuri 15-20 part, Radix Rubiae 15-20 part, Radix Glycyrrhizae 4-6 part.

3. the Chinese medicine composition treating pelvic inflammatory disease as claimed in claim 1 or 2, it is characterised in that its active component It is that employing water carries or the ethanol extraction of 40-80% concentration expressed in percentage by volume is prepared from.

4. the Chinese medicine composition treating pelvic inflammatory disease as claimed in claim 3, it is characterised in that its active component is Being prepared by the following method: take whole medical material, extracting in water 2-3 time after mixing, it is total that each amount of water is equivalent to medical material 6-12 times of weight, each extraction time is 1-3 hour, united extraction liquid, filters, and filtrate is concentrated into when 70-80 DEG C the closeest Degree is the clear paste of 1.15-1.20, obtains active component.

5. the Chinese medicine composition treating pelvic inflammatory disease as claimed in claim 3, it is characterised in that its active component is Being prepared by the following method: take whole medical material, use 40-80% alcohol reflux 2-3 time after mixing, each ethanol is used Amount is 4-10 times of medical material total amount, and extraction time is 1-4 hour, united extraction liquid, filters, and filtrate is concentrated into 70-80 DEG C of phase It is the clear paste of 1.15-1.20 to density, obtains active component.

6. the Chinese medicine composition treating pelvic inflammatory disease as claimed in claim 3, it is characterised in that its active component is Being prepared by the following method: take whole medical material, extracting in water 2-3 time after mixing, it is total that each amount of water is equivalent to medical material 6-12 times of weight, each extraction time is 1-3 hour, united extraction liquid, filters, and filtrate is concentrated into when 70-80 DEG C the closeest Degree is the clear paste of 1.15-1.20, adds ethanol, and making alcohol content is 40-70%, stands 12-24 hour, filters, and filtrate is concentrated into When 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.

7. treat a Chinese medicine composition for pelvic inflammatory disease, by the treatment pelvic inflammatory disease described in claim 1 or 2 Chinese medicine composition is prepared from pharmaceutically acceptable carrier combination.