CN104474467A

CN104474467A - Traditional Chinese medicine composition for treating Qi-stagnation and blood stasis type dysmenorrheal and preparation method of traditional Chinese medicine composition

Info

Publication number: CN104474467A
Application number: CN201410698028.7A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Shen Da New And High Technology Development Corp Ltd
Current assignee: Qingdao Shen Da New And High Technology Development Corp Ltd
Priority date: 2014-11-27
Filing date: 2014-11-27
Publication date: 2015-04-01

Abstract

The invention provides a traditional Chinese medicine composition for treating Qi-stagnation and blood stasis type dysmenorrheal. An oral preparation comprises the following raw material medicines: lithospermum, herba epimedii, polygala tenuifolia, Chinese angelica, leonurus, selfheal, astragalus membranaceus, fructus aurantii, rehmannia glutinosa, cassia twig, dogwood, glossy privet fruit, resina draconis, curcuma aromatic, red peony root, rose, rhizoma cyperi, corydalis tuber, salviae miltiorrhizae, ligusticum wallichii, caulis spatholobi and trigone; an external preparation comprises the following raw material medicines: rheum officinale, dipsacus asperoids, rhizoma cyperi, salviae miltiorrhizae, radix clematidis, corydalis tuber, cassia twig, cortex lycii radicis, loranthus parasiticus, resina draconis, divaricate saposhnikovia root, folium artemisiae argyi and safflower. The traditional Chinese medicine composition provided by the invention has dual effects on the uterus, namely causing excitation contraction when the uterus at a normal state, and loosening the uterus and perfecting the circulation when the uterus is at a spasm state, to reinforce the immunity of body cells so as to promote endometrium shedding and recovery and help to recover the period, amount, color and quality of menstruation, and the purpose of treating disease from the root of dysmenorrheal is achieved in clinic.

Description

A kind of Chinese medicine composition for the treatment of dysmenorrheal caused by qi stagnation and blood stasis and preparation method thereof

Technical field

The present invention relates to medicine configuration product, the particularly a kind of Chinese medicine composition for the treatment of dysmenorrheal caused by qi stagnation and blood stasis and preparation method thereof containing deriving from plant composition.

Background technology

Dysmenorrhea disease (dysmenorrhea), means before and after menstrual period or between menstrual period, occurs hypogastric region spasmic pain, and has general malaise, the person that has a strong impact on daily life.Divide constitutional and Secondary cases two kinds.Fail to find that pelvic organ has obvious abnormal person through detailed gynecological clinic inspection, claim primary dysmenorrhea, also claim primary dysmenorrhea.Secondary dysmenorrhea then refers to that genitals has obvious pathological changes person, as endometriosis, pelvic inflammatory disease, tumor etc.

Doctor trained in Western medicine dysmenorrhea diagnosis point " constitutional " and " Secondary cases ":

(1) primary dysmenorrhea, refers to through gynecologial examination, genitals without significant organic pathological changes person, multiple be born in menarche after 2-3 adolescent girls or the young woman of having given birth to.

(2) secondary dysmenorrhea, genitals has obvious organic disease person, has pelvic inflammatory disease, uterus tumor, endometriotic lesion induced pain warp through check-up such as gynecologial examination, Type B ultrasonoscopy, peritoneoscopes.

Closed by bimanual examination and three and examine, some causes of disease causing dysmenorrhea can be found, as uterine malformation, hysteromyoma, ovarian tumor, pelvic inflammatory disease block etc.Anus is examined and is laid one's hand on jarjavay's ligaments nodositas thickens, particularly important to early diagnosis endometriosis.

Other check: as erythrocyte sedimentation rate, leucorrhea antibacterial culturing, b surpass pelvic cavity scanning, hysterosalpingography, diagnosis dilatation and curettage of uterine, finally apply hysteroscope, laparoscopy can the pathogenic factor of clear and definite dysmenorrhea early.The slender faults omitted when hysteroscopy can find dilatation and curettage of uterine, as little muscular tumor, polyp, ulcer etc., and provides valuable diagnosis basis, can examine scrape after carry out.

3 degree can be divided into according to dysmenorrhea disease degree:

(1) slight: menstrual period or before and after it lower abdomen pain obvious, companion's waist is ached, but can adhere to work, without General Symptoms, sometimes needs to take analgesic.

(2) moderate: menstrual period or lower abdomen hurt like hell before and after it, companion's waist is ached, and nausea and vomiting, extremity are not warm, postpone by pain relieving measure pain.

(3) severe: menstrual period or lower abdomen hurt like hell before and after it, feels restless, has a strong impact on work and study and daily life, must lie up, companion's waist is ached, pale complexion, dripping cold sweat, extreme cold of the limbs, vomiting and diarrhoea, or rectal tenesmus, adopt pain relieving measure without obvious alleviation.

Cause the factor of dysmenorrhea disease a lot, common are following several:

(1) the narrow mainly menstruation outflow of cervical canal is obstructed, and causes dysmenorrhea.

(2) the not good easy merging blood supply of uterine hypoplasia developing womb is abnormal, causes uterus ischemia, anoxia and cause dysmenorrhea.

(3) if lagedes uterus uterus position extremely after to bend or anteflexion, the unobstructed and induced pain warp of menses can be affected.

(4) spirit, neural factors some women are to pain extrasensitivity.

(5) there is dysmenorrhea and mother's dysmenorrhea has certain relation in inherited genetic factors daughter.

(6) endocrine factors menstrual phase stomachache raises relevant with progesterone luteal phase.

(7) in endometrium and menstrual blood, prostaglandin (PG) content raises, and PGE2 (PGE2) acts on uterus muscle fiber and makes it contraction and cause dysmenorrhea.In patient uterine internal film tissue, Prostaglandin normal women obviously raises.

(8) excess shrinkage in uterus.Although dysmenorrhea patient uterine systolic pressure substantially identical with normal women (normal person's pressure is about 4.9Kpa), duration of uterine contraction is longer, and often not easily loosens completely, therefore the dysmenorrhea caused by the excess shrinkage of occurrence factor palace.

(9) the abnormal contraction in uterus.Dysmenorrhea patient often has the abnormal contraction in uterus, therefore often causes uterine leio myocardial ischemia, and the ischemia of uterus muscle can cause again the spasmodic contraction of uterus muscle, thus produces pain and occur dysmenorrhea.

(10) gynaecopathia is as endometriosis, pelvic inflammatory disease, adenomyosis, hysteromyoma etc.Intrauterine is placed birth control apparatus (being commonly called as intrauterine device) and is also easily caused dysmenorrhea.

(11) maiden's menophania, mental pressure is large, sitting causes qi-blood circulating variation, menses run freely, like that eating cold drink food etc. causes dysmenorrhea.

(12) menstrual period strenuous exercise, clammy invasion and attack etc. of having a cold, all easily cause dysmenorrhea.

(13) stuff by some industry or chemical property Odor stimulation, such as gasoline, oil of bananas etc. cause dysmenorrhea.

The traditional Chinese medical science thinks that dysmenorrhea is the disease of long-term, an easily recurrence, and menstrual period or puerperal experience cold-evil, or the cold and cool raw food of surfeit, and prolonged illness enters the reasons such as bloodization is tired can cause dysmenorrhea.Women take blood as this, belongs to cloudy; Cold being a kind of YIN pathogen, People of the same tastes and habits like to be together, and women itself easily feels cold-evil and causes gynaecopathia.Doctor thinks stagnation of blood stasis, stays and gathers for pain, long-pendingly forms tumor.Stagnation of blood stasis is primary disease pathogenesis core.Cause the reason that blood stasis is formed, mainly contain cold coagulation and the stagnation of QI.Patients factors body yang deficiency, or daily life is careless, paddles menstrual period and drenches with rain, eating cold and uncooked food excessively, experience cold-evil, and cold-evil visitor appoints in punching and causes cold blood stasis.Woman is kind, and how strongly fragrant bosom is, often cause irritability stasis, disorder of QI movement, and gas and blood maintains mutually, disorder of QI must and blood system, formation qi depression to blood stasis.In addition puerperal in menstrual period intemperate sexual intercourse, or delivery and feed infant is too much, and artificial abortion, the punching of cesarean equivalent damage are appointed and uterus, and healthy energy is impaired, and evil poison invasion is fought with blood and tie, finally causes stagnation of blood stasis, stays poly-not all right, blood stasis vapour lock, gradually long-pending addiction, formation primary disease.Due to stagnation of blood stasis, stagnation of QI and blood may bring about pain, with the passing of time blood stasis, long-pending forms addiction, stasis blocking vessels of the uterus, and two essences can not be harmonious, therefore clinical manifestation is dysmenorrhea, addiction abdominal mass, infertile etc.

Dysmenorrhea is one of modal disease of gynecological, and its incidence rate report differs, and account for 42% ~ 90%, wherein severe pain is through accounting for 18%, nausea and vomiting can be accompanied, dripping cold sweat, deadly cold hand and foot time serious, very then faint, affect life and work more, unfavorable to the physical and mental health of women; But the treatment to dysmenorrhea, there is no desirable Therapeutic Method, western medical treatment, mainly to reduce prostaglandin in menstrual blood and symptomatic treatment, by using prostaglandin enzyme inhibitor, reduces prostaglandin (Prostaglandin, PG) generation, prevented strong or spastic uterine contraction, thus alleviate or eliminate pain, but its curative effect can not be lasting, thoroughly can not cure dysmenorrhea, and there is obvious drug side effect problem.The traditional Chinese medical science is controlled by integral syndrome differentiation opinion and is started with, and treatment dysmenorrhea demonstrates obvious advantage, has broad prospects.

Summary of the invention

Technical problem to be solved by this invention is, dysmenorrhea is a disease that is long-term, easily recurrent exerbation, can accompany nausea and vomiting, dripping cold sweat, deadly cold hand and foot, very then faint, affect life and work more time serious, totally unfavorable to the physical and mental health of women.In treatment, the appearance of PGSI, the sickness rate of this disease is greatly reduced, ibuprofen modified release capsule has stronger antiinflammatory, pain relieving, refrigeration function, by suppressing prostaglandin synthetase, thus suppresses the synthesis of prostaglandin, produce anti-inflammatory analgesic effect, therefore ibuprofen modified release capsule is premenstruum, and use has the effect prevented irritation, using menstrual period has spasmolytic, analgesic activity, is characterized in that administration is easy, instant effect.But because its symptom mainly for its pain is eased pain, improve not good to simultaneous phenomenon, thoroughly can not cure dysmenorrhea, and because of side effect larger, can cause nausea, vomit, the gastrointestinal upset such as diarrhoea, also can cause stomatitis, dizziness, tinnitus, blurred vision, the untoward reaction such as erythra, therefore still can not think that oral ibuprofen slow releasing capsule is the Perfected process for the treatment of dysmenorrhea.Chinese medicine is started with by entirety, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs demonstrates obvious advantage.For the addiction disorders of blood machine of dysmenorrhea, endocrine disturbance is main pathogeny, in conjunction with the modern pharmacological research achievement of Chinese medicine, explores traditional Chinese medical herbal treatment dysmenorrhea and has vast potential for future development.

For solving above-mentioned technical barrier, the invention provides a kind of Chinese medicine composition for the treatment of dysmenorrheal caused by qi stagnation and blood stasis, in Chinese medicine composition described in it, oral preparations can comprise following crude drug: Radix Arnebiae (Radix Lithospermi), Herba Epimedii, Radix Polygalae, Radix Angelicae Sinensis, Herba Leonuri, Spica Prunellae, the Radix Astragali, Fructus Aurantii, Radix Rehmanniae Preparata, Ramulus Cinnamomi, Fructus Corni, Fructus Ligustri Lucidi, Sanguis Draxonis, Radix Curcumae, Radix Paeoniae Rubra, Flos Rosae Rugosae, Rhizoma Cyperi, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Caulis Spatholobi and Rhizoma Sparganii; In described Chinese medicine composition, external preparation can comprise following crude drug: Radix Et Rhizoma Rhei, Radix Dipsaci, Rhizoma Cyperi, Radix Salviae Miltiorrhizae, Radix Clematidis, Rhizoma Corydalis, Ramulus Cinnamomi, Cortex Lycii, Herba Taxilli, Sanguis Draxonis, Radix Saposhnikoviae, Folium Artemisiae Argyi Flos Carthami.

The Chinese medicine composition of described treatment dysmenorrheal caused by qi stagnation and blood stasis, in Chinese medicine composition described in it, oral preparations can comprise the crude drug of following parts by weight: Radix Arnebiae (Radix Lithospermi) 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Fructus Aurantii 10 ~ 20 parts, 10 ~ 20 parts, Radix Rehmanniae Preparata, Ramulus Cinnamomi 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Flos Rosae Rugosae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, in described Chinese medicine composition, external preparation can comprise the crude drug of following parts by weight: Radix Et Rhizoma Rhei 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Clematidis 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Cortex Lycii 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami.

The Chinese medicine composition of described treatment dysmenorrheal caused by qi stagnation and blood stasis, in Chinese medicine composition described in it, oral preparations can also comprise the crude drug of following parts by weight: Radix Arnebiae (Radix Lithospermi) 10 ~ 15 parts, Herba Epimedii 10 ~ 15 parts, Radix Polygalae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Spica Prunellae 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Fructus Aurantii 10 ~ 15 parts, 10 ~ 15 parts, Radix Rehmanniae Preparata, Ramulus Cinnamomi 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Flos Rosae Rugosae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, in described Chinese medicine composition, external preparation can also comprise the crude drug of following parts by weight: Radix Et Rhizoma Rhei 10 ~ 15 parts, Radix Dipsaci 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Radix Clematidis 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Ramulus Cinnamomi 10 ~ 15 parts, Cortex Lycii 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami.

The Chinese medicine composition of described treatment dysmenorrheal caused by qi stagnation and blood stasis, in Chinese medicine preparation described in it, oral preparations also can comprise the crude drug of following parts by weight: Radix Arnebiae (Radix Lithospermi) 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Fructus Aurantii 10 ~ 20 parts, 10 ~ 20 parts, Radix Rehmanniae Preparata, Ramulus Cinnamomi 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, Radix Curcumae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Flos Rosae Rugosae 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Rhizoma Sparganii 10 ~ 15 parts, in described Chinese medicine composition, external preparation also can comprise the crude drug of following parts by weight: Radix Et Rhizoma Rhei 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Clematidis 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Cortex Lycii 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, Radix Saposhnikoviae 10 ~ 15 parts, Folium Artemisiae Argyi 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami.

For solving above-mentioned technical barrier, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of dysmenorrheal caused by qi stagnation and blood stasis, and when the oral preparations of Chinese medicine composition described in it is honey refining pill, its preparation process is:

A. described crude drug is put into pulverizer grinding and sieving;

B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;

C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 2 times;

D. merged by above-mentioned two kinds of extracting solution, spraying dry after decompression recycling ethanol, obtains medicated powder; Mix the fine powder obtained that sieves and be twisted into pill together with Mel.

In described step a, described crude drug can be put into after pulverizer is pulverized and cross 120 order dusting covers, the enable fine powder amount by 120 mesh sieves is reaching 20%, collects by the crude drug fine powder of 120 mesh sieves for subsequent use.

In described step b, coarseparticulate remaining after above-mentioned steps can being sieved puts into ethanol, soaks more than 2 hours, add respectively account for crude drug gross mass 8 times amount, 6 times amount ethanol heating extraction 2 times, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, one-tenth extractum stand for standby use.

In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed can be added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, one-tenth extractum stand for standby use.

In described steps d, extractum can be extracted by above-mentioned 4 times and merge, when concentrating under reduced pressure relative density is 80 DEG C 1.28 pasty state, reclaim ethanol, gained pasty state is passed into spray dryer and carries out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 80 DEG C, obtains crude drug medicated powder; After being mixed with crude drug medicated powder by the crude drug fine powder obtained after sieving, be in harmonious proportion Mel, be twisted into pill.

For solving above-mentioned technical barrier, the present invention reoffers a kind of preparation method for the treatment of the Chinese medicine composition of dysmenorrheal caused by qi stagnation and blood stasis, the preparation process when external preparation of Chinese medicine composition described in it is enema is: put into except Folium Artemisiae Argyi, Rhizoma Cyperi and Sanguis Draxonis by described crude drug after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 30%, collects by the crude drug fine powder of 100 mesh sieves for subsequent use; Again the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; In described steps d, crystallization of Folium Artemisiae Argyi, Rhizoma Cyperi and Sanguis Draxonis distillation being vaporized to obtain, is dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.46, stir evenly after adding the crystalline powder of fine powder and the distillation of sieving, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.50 extractum, heating be condensed into pasty state, ultraviolet virus killing after use.

The technique effect that the present invention is useful is, the present invention can only be eased pain to the symptom of dysmenorrhea pain mainly for Western medicine, to simultaneous phenomenon improve not good, thoroughly can not cure dysmenorrhea, and because of side effect larger, can cause nausea, vomit, the gastrointestinal upset such as diarrhoea, also can cause stomatitis, dizziness, tinnitus, blurred vision, the untoward reaction such as erythra, Chinese medicine is started with by entirety, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs demonstrates obvious advantage.For the addiction disorders of blood machine of dysmenorrhea, endocrine disturbance is main pathogeny, in conjunction with the modern pharmacological research achievement of Chinese medicine, explores traditional Chinese medical herbal treatment dysmenorrhea and has vast potential for future development.The present invention has dual regulation to uterus, (namely cause excitation-contraction when uterus shows as in normal state, then cause lax when uterus is in spasticity) and improve circulation, the effect of enhancing body cellular immune function, reaches and promotes that endometrium comes off and repairs, and contributes to the phase of recovering menstruation, amount, color, matter, clinical treatment dysmenorrhea reaches the object for the treatment of must aim at the pathogenesis of disease.

Detailed description of the invention

Herba Leonuri, Radix Angelicae Sinensis, Ramulus Cinnamomi, Medulla Tetrapanacis itself all has effect of invigorating blood circulation addiction, Ramulus Cinnamomi, and Herba Asari is warm in nature, and two tastes share kind in inside and outside cold, " Plain Questions " regulating menstruation opinion cloud: vim and vigour person likes temperature and aversion to cold, cold then puckeryly can not to flow, temperature then drip and and go ".So reach logical object by Wen Yike, logical i.e. invigorating blood circulation addiction, has good analgesic effect, and modern study confirms, microcirculation improves can make uterus muscle hypoxic-ischemic alleviate to some extent.The present invention has anticoagulant, the sanguimotor effect of antithrombotic, blood vessel dilating and improvement, the anticoagulant of Herba Leonuri, and anti thrombotic action is also the embodiment of invigorating blood circulation addiction effect, and modern pharmacological research confirms to show; Invigorating blood circulation addiction Chinese medicine has the effect reducing menses and endometrium PG content, and infer that it may be one of pharmacological action for the treatment of primary dysmenorrhea, Papillary no matter is to stomachache or simultaneous phenomenon all has good improvement result.

After secondary dysmenorrhea is mainly in endometriosis, pelvic inflammatory disease, modern pharmacological research shows, Herba Leonuri Main Ingredients and Appearance total alkaloids has obvious antiinflammatory! Calm! Anti-dysmenorrhea effect, has antagonism to PG, obviously can reduce the content of inflammation uterus PG EZ, might be Herba Leonuri treatment constitutional! The active ingredient of secondary dysmenorrhea.The present invention also has antiinflammatory action.May be one of mechanism for the treatment of secondary dysmenorrhea.

Herba Leonuri is added in the present invention, it acts on the anticoagulant and antithrombus formation and analgesic and anti-inflammatory effects of strengthening Radix Angelicae Sinensis on the one hand, and on the other hand more outstanding behaviours go out the advantage property of medicine of Herba Leonuri itself: have dual regulation to uterus, (namely cause excitation-contraction when uterus shows as in normal state, then cause lax when uterus is in spasticity) and improve circulation, the effect of enhancing body cellular immune function, reach and promote that endometrium comes off and repairs, contribute to the phase of recovering menstruation, amount, color, matter, clinical treatment dysmenorrhea reaches the object for the treatment of must aim at the pathogenesis of disease.

Take a broad view of this research, we can think, Chinese patent medicine is selected on the basis of Chinese medical discrimination, be used for the treatment of dysmenorrhea, curative effect is rather good, retrospective research process, selected patient is dysmenorrheal caused by qi stagnation and blood stasis, takes the present invention's treatment, can reach the therapeutic effect for the treatment of must aim at the pathogenesis of disease, effective percentage is high, curative effect is lasting, safety, to the shortening stomachache time, change phase, amount, color, matter and picture of the tongue, the pulse condition of menstruation, improve the simultaneous phenomenons such as waist is ached, extreme cold of the limbs, all there is satisfied therapeutic effect aspect of improving the quality of living.Therefore, this medicine clinic is applied.

Radix Paeoniae Rubra is cool in nature, and bitter in the mouth acid, is slightly cold, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving.Yin fluid astringing receives the effects such as antiperspirant, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.Paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Rubra decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.The condition subject such as the blood deficiency deficiency of YIN, the breast abdomen pain over the hypochondriac region, pain in the hepatic region, cholecystitis, gallstone pain, dysentery stomachache, women's menalgia, spontaneous perspiration easy antiperspirant night sweat, sural spasm, spasm of the limbs pain, uneasy lower limb syndrome are suitable edible.

Fructus Ligustri Lucidi, sweet-bitter flavor, cool in nature, return Liver and kidney warp, there is nourishing the liver and kidney, merit that tonifying YIN nourishes blood.Modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods, has heart tonifying, diuresis and hepatoprotective effect, the leukopenia quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, escherichia coli.The acid of oleanolic acid Fructus Ligustri Lucidi, nuezhenoside, ursolic acid, stearic acid, oleic acid, mannitol, betulin, phospholipid and saccharide is contained as Fructus Ligustri Lucidi polysaccharide, arabinose, glucose etc. in Fructus Ligustri Lucidi, also containing 15 seed amino acids, 11 kinds of trace element and volatilization wet goods.Research thinks that Fructus Ligustri Lucidi has blood sugar lowering and blood fat reducing and has study of anti-atherogenic effect, and antibacterial, antivirus action in addition, Fructus Ligustri Lucidi decoct all has inhibitory action to staphylococcus aureus, shigella flexneri, Bacillus typhi, bacillus pyocyaneus and escherichia coli.

Radix Polygalae (formal name used at school: Polygala tenuifolia Willd.) is Polygalaceae, rogation flower.Produce northeast, North China, northwest and Central China and Sichuan.Warm in nature, bitter in the mouth, pungent, the function of have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Clinical practice crude Radix Polygalae, Radix Polygalae (processed) and honey polygala root three kinds.

Fructus Corni, cure mainly pathogen cold and heat under the heart, warming middle-JIAO, by cold temperature numbness, goes three worms, for a long time clothes made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, stop the merit of dribbling urination; Take improving eyesight, brute force for a long time all the year round.Fructus Corni, have another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., for China commonly uses rare Chinese medicine, applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.Zhang Zhongjing is that monarch has formulated " JINGUI SHENQI WAN " with Fructus Corni.According to chemical analysis, Fructus Corni contains the effective ingredient such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibacterial, is the Herba indigoferae Pseudotinctoriae commonly used in tcm clinical practice.

Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese crude drug, there is YIN nourishing effect of enriching blood, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also diseases such as can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, pass out semen, quench one's thirst is one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.The all cards of the hepatic and renal YIN deficiency, this quality is moistened into kidney, and kind nourishing kidney yin, life essence-filling, marrow-benefitting is the key medicine of tonifying kidney-yin.Ancients call it " large tonifying five ZANG-organs is Kidney-Yin ", " the true water of large benefit ".Often be equal to use with Rhizoma Dioscoreae, Fructus Corni, the treatment hepatic and renal YIN deficiency, soreness of the waist and knees, seminal emission, night sweat, tinnitus, deafness and quench one's thirst, can invigorating the liver and kidney, beneficial marrow, as LIUWEI DIHUANG WAN.

The plant that Radix Arnebiae (Radix Lithospermi) (formal name used at school: Lithospermum erythrorhizon) is Boraginaceae Lithospermum.This showy flowers of herbaceous plants Rhizoma Seu Herba Bergeniae is purple, can contaminate purple, therefore named.Have another name called mountain Radix Arnebiae (Radix Lithospermi), Zi Dan, purple cottonrose hibiscus, small, blood, crow rank grass, Radix Arnebiae (Radix Lithospermi).Nature and flavor: cold in nature are sweet in the mouth, salty.GUIXIN, Liver Channel.Effect is classified: hemorrhage; Blood-cooling drugs; Heat and toxic materials clearing away medicine function cures mainly removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention.Also have and dislike insect bite wound.

Herba Epimedii herb hyoscine.Cure mainly impotence and premature ejaculation, pain in the low back and legs, numb limbs and tense tendons, hemiplegia, neurasthenia, forgetful, tinnitus, dizzy disease such as grade.Herba Epimedii is Chinese conventional Chinese medicine.Kidney invigorating and YANG supporting, expelling wind and removing dampness.Control sexual impotence erectile problem, hemiplegia is unsuccessful, dribbling urination, and muscles and bones contraction is anxious, and cough, optic atrohic blindness after being ill, toothache caused by fire of deficiency type, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless." herbal classic ": main impotence is hindered absolutely, pains in the penis.Diuresis, physical strength profiting, Qiang Zhi." not Lu ": hard muscles and bones.Disappear scrofula, red carbuncle; Skin ulcer is arranged at bottom, washes, and goes out worm." Japan hanako materia medica ": control all cold wind consumptive disease, mend waist knee joint, heart tonifying power, husband is exhausted, and sun does not rise, the exhausted cloudy loss of fecundity of woman, and muscles and bones contraction is anxious, and extremity are not appointed, and old man's dusk octogenarian, the middle age is forgetful.

Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.Herba Leonuri, containing the material such as leonurine, Fumaric acid, has the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.External is gynecological's good medicine of activating blood circulation to dissipate blood stasis.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Spica Prunellae is cold in nature, sweet in the mouth, pungent, micro-hardship, there is the effect of letting out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis, be applicable to lymphoid tuberculosis, goiter, acute mastitis, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, metrorrhagia, leukorrhagia, Fiedeler's disease type hepatitis and bacillary dysentery etc.Modern pharmacological research shows, Spica Prunellae has the effect reduced blood pressure, and energy blood vessel dilating, contained by it, rutin has antiinflammatory action, and can reduce vascular permeability, reduces fragility, reduces liver fat.Spica Prunellae also has the effect of resisting cancerous cell." herbal classic ": main cold and heat, scrofula, scrofula, head sore, broken disease, loose wart stagnation of QI, swelling of the feet arthralgia chiefly caused by damp pathogen." Amplification on Materia Medica addendum ": take a tonic or nourishing food to build up one's health blood vessels.

The Radix Astragali has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, and food stagnation is stagnated, carbuncle from the beginning of or the excess syndrome such as pyretic toxicity Shang Sheng after bursting.The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst." herbal classic " is recorded: " main carbuncle, loses skin ulcer for a long time, evacuation of pus pain relieving.Tonify deficiency, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas strengthening bone and muscle, put on flesh and enrich blood.”

Fructus Aurantii dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse." property of medicine opinion ": control rubella all over, dislikes as numb bean in flesh and itches, main hemorrhoidal hamorrhage haemorrhoids, stagnation of QI in chest and abdomen, and the swollen void of two sides of body, pass diaphragm is congested." Japan hanako materia medica ": spleen benefiting and stimulating the appetite, adjust the five internal organs, the therapeutic method to keep the adverse QI flowing downwards, preventing or arresting vomiting is inverse, expectorant.Control regurgitation, cholera dysentery, helps digestion, and broken crux mass beside the umbilicus, five types of dysphagia, except wind improving eyesight and lung qi edema, sharp intestine and small intestine, skin is itched.Swollen can the processing of hemorrhoid is pressed." Kaibao Bencao ": main air is itched paralysis, easing joint movement, consumptive disease is coughed, and back of the body arm is bored and listless, loosely stays knot, chest and diaphragm expectorant stagnant, and relieve oedema or abdominal distension through diuresis or purgation, full, the large hemorrhoidal hamorrhage of relieving distension, peace stomach, only wind bitterly.

The current domestic Dragon Blood of Sanguis Draxonis mostly is Liliaceae Dracaena cochinchinensis or dracaena cambodiana Pierre resin.Foreign resina draconis is comparatively rare.Yunnan Folium Dracaenae cambodianae is damaged rear flowed out myron can make Sanguis Draxonis through processing.Effect takes promoting blood circulation to remove blood stasis orally, analgesic therapy, external hemostasia and promoting granulation, sore.Cure mainly 1. congestion amenorrhea, dysmenorrhea, postpartum stagnation.2. lump in the abdomen mass in the abdomen, breast ventral spine pain.3. traumatic injury, congestion swells and ache.4. traumatic hemorrhage, ulcer being unable to heal.

Radix Curcumae this product is the dried root of zingiberaceous plant RADIX CURCUMAE Curcumawenyujin Y.H.Chen et C.Ling, Rhizoma Curcumae Longae Curcuma longaL..The above two practise title " RADIX CURCUMAE " and " Radix Curcuma " respectively, and all the other are practised by character difference and claim " osmanthus Radix Curcumae " or " green filament Radix Curcumae ".Winter, stem and leaf was excavated after withering, and removing silt and radicula, steam or boil to the saturating heart, dry.Nature and flavor with return through: pungent, bitter, cold.Return liver, the heart, lung meridian.Function cures mainly: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, and clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.

Road in Flos Rosae Rugosae " herbal text ": " Flos Rosae Rugosae, turbid clearly and not, and and violent, easing the affected liver is waken up stomach, and thin gas is invigorated blood circulation, and a surname is logical stops up stagnant and absolutely not pungent temperature is just dry fraud, disconnectedly pushes away among edema caused by disorder of QI medicine, has prompt effect and the most tractable most, and fragrant all product, there is no equal.Containing 300 various chemical components in Flos Rosae Rugosae, as the alcohol of fragrance, aldehyde, fatty acid, phenol and containing the oil of essence and fat, to wake up stomach with easing the affected liver in normal food Flos Rosae Rugosae goods, have a respite and invigorate blood circulation, looks improving and the skin nourishing, make us refreshing refreshing.The flower opened at the beginning of Flos Rosae Rugosae and root can be used as medicine, and regulate the flow of vital energy, invigorate blood circulation, Thyme Extract, cure mainly menoxenia, and traumatic injury, irritability are had a stomachache, the diseases such as newborn too fat to move pain.The sarcocarp of Rosehips, can be made into fruit jam, has flavour, and fruit contains abundant vitamin C and Citrin, and acute and chronic infectious disease, coronary heart disease, hepatopathy and prevention can be prevented to produce carcinogen etc.With the Flos Rosae Rugosae quintessence oil (title Liquor Rosae Rugosae Distillata) that roseleaf obtains with way of distillation refinement, androgen and sperm can be activated.Liquor Rosae Rugosae Distillata can also improve skin texture, blood circulation promoting and metabolism.

Rhizoma Cyperi is regulated the flow of vital energy resolving depression; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang ex Z.Y.Su et C.Y.Wu), Papaveraceae, Corydalis perennial herb, another name: Rhizoma Corydalis, corydalis tuber, rhizoma corydalis, Rhizoma Corydalis.Chinese tradition medical material.Mainly originate in Zhejiang and Jiangsu.Its tuber (Rhizoma Corydalis Decumbentis), containing the multiple alkaloid such as corydaline, protopine, through making powder or fluid-acet-extract etc., cures mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.There are analgesia, calmness, syngignoscism.

Rhizoma Chuanxiong enters liver, spleen, three burnt three warps.Function cures mainly activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." detailed outline " carries: " dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine removes vascular smooth muscle (aortic article) spasm (epinephrine, potassium chloride cause).Can also coronary vasodilator be expanded, increase coronary flow.The myocardial ischemia-anoxemia that antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that ligation arteria coronaria causes.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Rhizoma Sparganii, the blue or green Rhizoma Zingiberis Recens that has another name called, evil mind Rhizoma Zingiberis Recens, Rhizoma Curcumae Longae, Latin name: Curcuma zedoaria (Christm.) Rosc., Rhizoma Sparganii is Zingiberaceae, Curcuma perennial root draft, plant height about 1 meter; Rhizome is cylindrical, meat, fragrance as tool Camphora, faint yellow or white; Elongated or the end of root enlarges into tuber.Cultivation or wild under Lin Yin, there are distribution in the many ground of China, India to Malaysia.There is the effect of removing blood stasis promoting the circulation of QI to relieve pain, long-pending eliminating stagnation, removing blood stasis, promoting the circulation of QI to relieve pain.Rhizome claims " Rhizoma Sparganii ", hyoscine, cures mainly that " lump in the abdomen, gathers, and dyspepsia does not disappear for coagulation of QI-blood, trusted subordinate's distending pain, and women's blood stasis amenorrhea, traumatic injury is had a pain." tuber claims " green filament Radix Curcumae ", has promoting QI circulation for relieving depression, removing blood stasis with potent drugs, the function of pain relieving.Removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate's distending pain, gather, women's blood stasis amenorrhea, traumatic injury is had a pain eating accumulation.(1) promoting the circulation of QI to relieve pain, removing blood stasis removing food stagnancy: for the amenorrhea of qi depression to blood stasis, chest and hypochondrium, stomachache and lump in the abdomen lump etc.Often join Rhizoma Sparganii.(2) promoting digestion and removing stagnation: for the stomach abdominal distention and pain of eating accumulation, often join Fructus Hordei Germinatus (parched to brown), Semen Arecae Prepareta.

Its nature and flavor of Ramulus Cinnamomi are pungent, sweet, temperature, enter lung, the heart, urinary bladder channel, cure mainly the conventional drugs for dispelling internal cold of interior cold, there is effect of complement sun, promoting blood circulation, warming the spleen and stomach, normal with invigorating the liver and kidney medicine, fill blood medicine compatibility, treats insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, treat coldness and pain in the epigastrium, arthralgia due to cold lumbago with other drugs for dispelling internal cold compatibility, there is the effect of significantly analgesia and anti-cancer and cancer-preventing.Existing various wind dispelling oils medicine is if menthocamphorate, rheumatism wet goods are all containing cassia oil composition.

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Radix Et Rhizoma Rhei nature and flavor: bitter, cold.Gui Jing: spleen, stomach, large intestine, liver, pericardium channel.Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances.Cure mainly: excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald.

Radix Dipsaci, Chinese medicine name.Having another name called shaven head, is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, gains the name because of energy " synthetism of continuous folding ".Autumn excavates, and removing root head and fibrous root, be dried to half-dried with low baking temperature, when bank up " diaphoresis " is to inner virescence, then dries." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians determine in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, and antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”

Radix Clematidis belongs to medicinal plants, and medical material Ji Yuan originates more, and the Radix Clematidis that " Kaibao Bencao ", " Bencao Tujing ", herbal for Relief of Famines etc. are contained is goatweed; The Radix Clematidis that " the southern regions of the Yunnan Province book on Chinese herbal medicine " is contained is feverfew, and use now mostly be " China's book on Chinese herbal medicine " contained cohosh Radix Clematidis, Clematis hexapetala, northeast clematis.Domestic distributed more widely, its root and stem be used as medicine there is rheumatism, effect that the meridian dredging, the bone that disappears are choked.In modern clinic practice, its new purposes is constantly found, as treatment cholelithiasis, and calcanean spur, talalgia, the esophageal carcinoma etc.But it is noted that in medication, deficiency of qi and blood and the careful clothes of anemia of pregnant woman.

Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension." Bencao Jingshu ": Herba Taxilli, its bitter but sweet flavor, its gas is gentle, cold not hot, admittedly should be nontoxic.It cures mainly in detail, take out its elite for one, therefore function compares Sang Yousheng in Mulberry.Lumbago and children's's stiffback, all time of insufficiency of blood, carbuncle is many due to ying-qi heat.Skin does not fill, due to blood deficiency.Tooth person, originator, beneficial blood then sends out China after blood also, and the sufficient then tooth of kidney qi is hard and an eyebrow is long after bone also.Blood contains then tire peace certainly.Woman's metrorrhagia and internal injury deficiency, all events of blood deficiency interior-heat.Disease more than puerperal, all by blood system, agalactia, also by blood deficiency.Incised wound is then hindered entirely in blood.To come up all diseases, there's no one who doesn't or isn't know and have heat institute to send out by blood deficiency, this property of medicine can beneficial blood, thus also lead also.Hold concurrently and can wet by core, therefore also treat numbness.

Radix Saposhnikoviae returns through urinary bladder channel; Lung meridian; Spleen channel; Liver Channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly: affection of exogenous wind-cold; Headache general pain; Rheumatic arthralgia; Joint is ached; Stomachache is had loose bowels; Discharging fresh blood stool; Tetanus; Rubella pruritus; Skin infection from the beginning of." herbal classic ": main large dizziness due to wind pain, aversion to wind, ailment said due to cold or exposure, order blindness, is in fashion the whole body, arthralgia numbness, stuffy sensation with restlessness.Collective Notes to the Canon of Materia medica: kill Radix Aconiti Lateralis Preparata poison.

Folium Artemisiae Argyi is the dried leaves of feverfew Chinese mugwort Artemisia argyi Levl.et Vant..Most of China area is all produced.Be good with Hubei Qi Zhou (local of Li Shizhen (1518-1593 A.D.)) product person, claim " Artemisia argyi Levl. et Van. var. argyi cv. Qiai ", because it obtains rustic suitable, leaf is thick and floss is many, and as the material of moxibustion treatment, power is maximum.Pluck when summer, flower was not opened, removing impurity, dries or dries in the shade.Folium Artemisiae Argyi acrid in the mouth, hardship, warm in nature, there is warming the meridian for stopping bleeding, dispersing cold for relieving pain, effect of wet down parasite killing.Folium Artemisiae Argyi acrid in the mouth, hardship, warm in nature, nontoxic; Return spleen, liver, kidney channel; Fragrance temperature is loose, can rise to fall to have warming the meridian for stopping bleeding, dispersing cold for relieving pain, and effect of wet down parasite killing, cures mainly menoxenia, dysmenorrhea, infertility, frequent fetal movement, trusted subordinate's cold type of pain, spits blood, epistaxis, and spitting of blood, has blood in stool, metrorrhagia, gestation hemorrhage, chronic dysentery of having loose bowels, leukorrhagia, eczema, scabies, carbuncle, hemorrhoid.Moxibustion treatment all kinds of diseases and ailments.

Flos Carthami, another name: red indigo plant flower thorn Flos Carthami, Latin literary fame: Carthamus tinctorius L. Compositae, Flos Carthami platymiscium, dry tubular flower, is about 1.5 centimetres, orange red, floral tube is carefully narrow, and tip 5 splits, and sliver is narrow linear, long 5 ~ 8 millimeters, 5 pieces, stamen, flower pesticide is yellow, is unified into pipe, exceed outside sliver, its central authorities have stigma to expose.The special fragrance of tool, mildly bitter flavor.To spend, length of a film, color are scarlet, the soft person of matter is good.The ground such as main product Henan, Hunan, Zhejiang, Sichuan.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, swells and ache for amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, traumatic injury, skin infection.Have blood circulation promoting and blood stasis dispelling, wet dissipation goes the effect swollen, but anemia of pregnant woman will be avoided to use, otherwise can cause miscarriage.Flos Carthami can be used for foot bath, contributes to accelerating foot's blood circulation.

Cortex Lycii is the dry root bark of matrimony vine of solanaceae plant or lycium barbarum.Nature and flavor: sweet, cold.Return lung, liver, kidney channel.Function removing heat from blood, reducing the asthenic fever, purte the white.Be applicable to deficiency of YIN hectic fever, night sweat, hectic fever due to YIN-deficiency; Cough due to lung-heat; Bleeding due to blood-heat go out blood disorder.Shennong's Herbal is recorded: " in main five, pathogen, hankers quenching one's thirst, general arthralgia." therefore, ancient books is also recorded and confirmed that Cortex Lycii can control diabetes (diabetes).The main component of Cortex Lycii is: containing cinnamic acid and volume aldehydes matter, and betanin is still separated to B mono-sitosterol, linoleic acid and Kukoamine etc.These effective compositions can reduce " three-hypers " (hyperlipidemia, hypertension, hyperglycemia) just.Blood sugar lowering process mainly has facilitation to B cell excreting insulin.Modern pharmacology also confirms, the oral blood glucose that makes of its decoct reduces, and presents reduction blood fat.Can also reduce blood pressure, decreasing heart rate, heavy dose can cause atrioventricular block.Modern Chinese medicine is clinical also applies Cortex Lycii treatment diabetes widely, and decocting, for tea drink frequently, has certain blood sugar lowering and lipid-lowering effect; As Cortex Lycii made the decocting liquid of 4% concentration, white sugar of suitably adding some points, also has good curative effect to blood pressure lowering.

Specific embodiment 1: the preparation of oral solutions of the present invention

Get crude drug Radix Arnebiae (Radix Lithospermi) 1000g, Herba Epimedii 1000g, Radix Polygalae 1000g, Radix Angelicae Sinensis 1000g, Herba Leonuri 1000g, Spica Prunellae 1000g, Radix Astragali 1000g, Fructus Aurantii 1000g, Radix Rehmanniae Preparata 1000g, Ramulus Cinnamomi 1000g, Fructus Corni 1000g, Fructus Ligustri Lucidi 1000g, Sanguis Draxonis 1000g, Radix Curcumae 1000g, Radix Paeoniae Rubra 1000g, Flos Rosae Rugosae 1000g, Rhizoma Cyperi 1000g, Rhizoma Corydalis 1000g, Radix Salviae Miltiorrhizae 1000g, Rhizoma Chuanxiong 1000g, Caulis Spatholobi 1000g, Rhizoma Sparganii 1000g; Getting all crude drug medicines steeps in water, soaks more than 2 hours, add respectively account for crude drug medicine gross mass 8 times amount, 6 times amount water extraction 2 times, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.The medicinal residues of crude drug medicine said extracted crossed add ethanol, and add the ethanol warm macerating 2 times of 10 times amount of medicinal residues gross weight, 8 times amount respectively, the warm macerating time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm macerating liquid; Warm macerating liquid is evaporated to 1.25 extractum when density is 60 DEG C, and extractum is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.By also 2-in-1 to component 1 and component, when concentrating under reduced pressure relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, inserted in economic benefits and social benefits vacuum concentrator by above-mentioned two kinds of extracting solution, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.60, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again and is condensed into extractum, adds Mel or dextrin mediation, canned after ultraviolet radiation for sterilizing and disinfecting.

Specific embodiment 2: the preparation of capsule of the present invention

Get crude drug Radix Arnebiae (Radix Lithospermi) 1200g, Herba Epimedii 1100g, Radix Polygalae 1200g, Radix Angelicae Sinensis 1100g, Herba Leonuri 1100g, Spica Prunellae 1200g, Radix Astragali 1200g, Fructus Aurantii 1200g, Radix Rehmanniae Preparata 1100g, Ramulus Cinnamomi 1200g, Fructus Corni 1200g, Fructus Ligustri Lucidi 1200g, Sanguis Draxonis 1200g, Radix Curcumae 1200g, Radix Paeoniae Rubra 1200g, Flos Rosae Rugosae 1200g, Rhizoma Cyperi 1200g, Rhizoma Corydalis 1200g, Radix Salviae Miltiorrhizae 1200g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1200g, Rhizoma Sparganii 1200g, get crude drug medicine clean dry, in 70 DEG C of baking ovens, dry 1-3h, taking-up is placed in cooling in drying baker, 80-100 mesh sieve was pulverized with pulverizer.By for subsequent use for the fine powder sieved, unsifted coarse granule one bubbles in ethanol after 1-2 days, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2g crude drug amount, is then dried to powder, adds the fine powder sieved, ultraviolet disinfection, canned capsule.

Specific embodiment 3: the preparation of Tablets

Get crude drug Radix Arnebiae (Radix Lithospermi) 1300g, Herba Epimedii 1100g, Radix Polygalae 1100g, Radix Angelicae Sinensis 1100g, Herba Leonuri 1100g, Spica Prunellae 1200g, Radix Astragali 1200g, Fructus Aurantii 1200g, Radix Rehmanniae Preparata 1100g, Ramulus Cinnamomi 1200g, Fructus Corni 1200g, Fructus Ligustri Lucidi 1300g, Sanguis Draxonis 1200g, Radix Curcumae 1400g, Radix Paeoniae Rubra 1200g, Flos Rosae Rugosae 1400g, Rhizoma Cyperi 1200g, Rhizoma Corydalis 1400g, Radix Salviae Miltiorrhizae 1300g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1200g, Rhizoma Sparganii 1300g, be mixed and put into acid and alkali-resistance infusion kettle, at room temperature, 3 ~ 7 days are flooded together with more than 70 degree ethanol, then heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, filter, filtrate is got after separation, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge lixiviating solution, being condensed into pasty state becomes component 2, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the extractum of 1.60, is dried to powder, adds starch tabletting.

Specific embodiment 4: the preparation of pill of the present invention

Get crude drug Radix Arnebiae (Radix Lithospermi) 1100g, Herba Epimedii 1100g, Radix Polygalae 1300g, Radix Angelicae Sinensis 1100g, Herba Leonuri 1100g, Spica Prunellae 1200g, Radix Astragali 1200g, Fructus Aurantii 1200g, Radix Rehmanniae Preparata 1100g, Ramulus Cinnamomi 1200g, Fructus Corni 1200g, Fructus Ligustri Lucidi 1200g, Sanguis Draxonis 1200g, Radix Curcumae 1300g, Radix Paeoniae Rubra 1200g, Flos Rosae Rugosae 1300g, Rhizoma Cyperi 1200g, Rhizoma Corydalis 1200g, Radix Salviae Miltiorrhizae 1200g, Rhizoma Chuanxiong 1300g, Caulis Spatholobi 1200g, Rhizoma Sparganii 1200g; Getting all crude drug medicines steeps in water, soaks more than 2 hours, add respectively account for crude drug medicine gross mass 8 times amount, 6 times amount water extraction 2 times, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.The medicinal residues of crude drug medicine said extracted crossed add ethanol, and add the ethanol warm macerating 2 times of 10 times amount of medicinal residues gross weight, 8 times amount respectively, the warm macerating time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm macerating liquid; Warm macerating liquid is evaporated to 1.25 extractum when density is 60 DEG C, and extractum is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.Extract extractum by above-mentioned 4 times to merge, when concentrating under reduced pressure relative density is 80 DEG C 1.28 pasty state, reclaim ethanol, gained pasty state is passed into spray dryer and carries out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 80 DEG C, obtains crude drug medicated powder; Add Mel and be twisted into pill.

Specific embodiment 5: the preparation of external enema of the present invention

Described crude drug Radix Et Rhizoma Rhei 1500g, Radix Dipsaci 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Clematidis 1500g, Rhizoma Corydalis 1500g, Ramulus Cinnamomi 1500g, Cortex Lycii 1500g, Herba Taxilli 1500g, Radix Saposhnikoviae 1500g, Flos Carthami 1500g are put into after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 30%, collects by the crude drug fine powder of 100 mesh sieves for subsequent use; The particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution is merged and leaves standstill; The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; In described steps d, crystallization of Folium Artemisiae Argyi 1500g, Rhizoma Cyperi 1500g and Sanguis Draxonis 1500g distillation being vaporized to obtain, is dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.46, stir evenly after adding the crystalline powder of fine powder and the distillation of sieving, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.50 extractum, heating be condensed into pasty state, ultraviolet virus killing after use.

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolved by adding distil water of the present invention, be made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18 to dosage by crude drug amount, 14.4,11.5,9.2,7.4 (g.kg ^-1), in animal fasting (can't help water) after 18 hours, administration at twice in a day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of white mice, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicated powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicated powder dosage is > 42g/kg. day (every g medicated powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with matched group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safety range of the present invention is comparatively large, is a kind of safe and reliable health product.

Pharmacological experiment:

One, dysmenorrhea is one of modal disease of gynecological, and its incidence rate report differs, and account for 42% ~ 90%, wherein severe pain is through accounting for 18%, nausea and vomiting can be accompanied, dripping cold sweat, deadly cold hand and foot time serious, very then faint, affect life and work more, unfavorable to the physical and mental health of women; But the treatment to dysmenorrhea, there is no desirable Therapeutic Method, western medical treatment, mainly to reduce prostaglandin in menstrual blood and symptomatic treatment, by using prostaglandin enzyme inhibitor, reduces prostaglandin (Prostaglandin, PG) generation, prevented strong or spastic uterine contraction, thus alleviate or eliminate pain, but its curative effect can not be lasting, thoroughly can not cure dysmenorrhea, and there is obvious drug side effect problem.The traditional Chinese medical science is controlled by integral syndrome differentiation opinion and is started with, and treatment dysmenorrhea demonstrates obvious advantage, has broad prospects.

The traditional Chinese medical science thinks that dysmenorrhea is the disease of long-term, an easily recurrence, and menstrual period or puerperal experience cold-evil, or the cold and cool raw food of surfeit, and prolonged illness enters the reasons such as bloodization is tired can cause dysmenorrhea, common with syndrome of qi stagnation and blood stasis clinically, disease sees premenstrual inferior belly gas pain, acute through row pain, pain draws waist sacrum, and pain is very fainted, abdominal pain with tenderness; Blockage of menstruation, has held clot under the arm, alleviation of pain under block; Rectal tenesmus; Premenstrual distending pain of the breast, does not uncomfortable in chestly relax; Dyspareunia; Purplish tongue is dim, limit is sharp has ecchymosis, white and thin fur, stringy pulse.

This research, by taking ibuprofen modified release capsule as matched group, inquires into the Clinical efficacy and safety that the present invention treats dysmenorrheal caused by qi stagnation and blood stasis.

Two, case source

In March, a 2011 ~ 2013 year attached Shandong Fu Chan children's hospital of Shandong Traditional Chinese Medicine University in March is selected to meet diagnostic criteria, the outpatient service of inclusive criteria and inpatient.

Three, diagnostic criteria

(1) Western medicine diagnose standard

With reference to the diagnostic criteria about dysmenorrhea in " guideline of clinical investigations of traditional Chinese medical science Drugs in Therapy dysmenorrhea " (version in 1993),

1. primary dysmenorrhea refers to through gynecologial examination, genitals without significant organic pathological changes person, multiple be born in menarche after the adolescent girls of 2 ~ 3 years or the young woman of not giving birth to.

2. secondary dysmenorrhea genitals has obvious organic disease person, and through gynecologial examination, Type B ultrasonoscopy, the check-up such as peritoneoscope have pelvic inflammatory disease, hysteromyoma, endometriotic lesion and the dysmenorrhea caused.

According to the practical situation of this research, the secondary dysmenorrhea of selection is all the patients after the capable conservative operation dealing of endometriosis.

(2) Standards of Chinese Medical Syndrome Differentiation

Disease sees premenstrual inferior belly gas pain, and acute through row pain, pain draws waist sacrum, and pain is very fainted, abdominal pain with tenderness; Blockage of menstruation, has held clot under the arm, alleviation of pain under block; Rectal tenesmus; Premenstrual distending pain of the breast, does not uncomfortable in chestly relax; Dyspareunia; Purplish tongue is dim, limit is sharp has ecchymosis, white and thin fur, stringy pulse.

Primary symptom: premenstrual or menstrual period lack abdomen cold type of pain, pain alleviated while getting warmth, simultaneous phenomenon:

1. month through or see and postpone, amount is few, dim and have tired piece or as decoction of black soybean sample through color; 2. complexion is bluish white; 3. cold extremities with aversion to cold; 4. nausea and vomiting, waist bones of the body distending pain or rectal tenesmus; 5. the dim tongue of tongue is white; 6. deep-thready pulse or stringy and tense pulse, wherein cardinal symptom is indispensable, and simultaneous phenomenon possesses 2 and can diagnose.

(3) pain degree, symptom Quantitative marking standard

With reference to (guideline of clinical investigations 6 (version in 1993) of new Chinese medicine treatment dysmenorrhea "

1. pain degree standards of grading (see annex 1)

With reference to (guideline of clinical investigations 6 (version in 1997) of new Chinese medicine treatment dysmenorrhea "

2. tcm symptom Quantitative marking standard (see annex 2)

(4) dysmenorrhea grade scale

Draft with reference to " guideline of clinical investigations of new Chinese medicine treatment dysmenorrhea " (version in 1993):

1. severe: menstrual period or lower abdomen hurt like hell before and after it, feel restless, have a strong impact on work, study and daily life, must lie up, ache with waist, complexion is looked into the distance white, dripping cold sweat, extreme cold of the limbs, vomiting and diarrhoea, or rectal tenesmus, adopt pain relieving measure without obvious alleviation, dysmenorrhea symptom integral is more than 14 points;

2. moderate: menstrual period or lower abdomen hurt like hell before and after it, companion's waist is ached, nausea and vomiting, and extremity are not warm, and postpone separating with pain relieving measure, dysmenorrhea symptom integral is at 8 ~ 13.5 points;

3. slight: menstrual period or before and after it lower abdomen pain obvious, companion's waist is ached, but can adhere to work, and without General Symptoms, sometimes must take analgesic, dysmenorrhea symptom integral is below 8 points.

Four, inclusive criteria

(1) constitutional or secondary dysmenorrhea women, belong to qi depression to blood stasis person through Chinese medical discrimination; (2) secondary dysmenorrhea is the patient after the capable conservative operation dealing of endometriosis; (3) age was at 16 ~ 50 years old; (4) other Medicine and Surgery diseases of nonjoinder; (5) agree to reception test group or group treatment, and sign the patient of Informed Consent Form.

Five, exclusion standard

(1) Syndrome Differentiation of Traditional Chinese Medicine does not belong to qi depression to blood stasis person; (2) dysmenorrhea caused by pelvic inflammatory disease, endometriosis, uterus tumor is confirmed on inspection; (3) to known applications drug allergy person; (4) the severe primary diseases such as cardiovascular and cerebrovascular vessel, liver, kidney and hemopoietic system are associated with, psychotic; (5) do not meet inclusive criteria, not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person; (6) do not agree to reception test group or treatment of control group, do not sign the patient of Informed Consent Form.

Six, concrete condition illustrates: 1. medication is more than 1 menstrual cycle person, should enter curative effect statistics; More than medication 1 cycle (comprising 1 cycle) invalid stop using or use other similar therapeutic medicines instead, should by invalidation, not in the scope of coming off, the present invention treats in the observation of curative effect of qi depression to blood stasis dysmenorrhea; 2. medication does not reach the experimenter of 9 days, can be considered the case that comes off; 3. the patient that pair midway proposes to exit test by patient clearly will record reason; Medication is passed through and last administration time; 4. the patient of pair lost to follow-up or institute's further consultation that do not come in time, should make great efforts by telephone questionnaire reason, investigate its medication process, last administration time, and keep a record; 5. evaluation index when itemized record stop, stopping test or come off will conscientious record with the relation of test, analyzes and stops case may affect research conclusion; 6. keep the raw data of all rejectings and the case that comes off.

Seven, grouping and test method

(1) EXPERIMENTAL DESIGN

This research adopts clinical experimental study method, selects ibuprofen modified release capsule as standard control medicine, using the present invention as test group, Chinese medicine pharmacy of institute decocts to 200ml by prescription unification by me, sealing, and menstruation first day starts oral, day 1 dose, and sub-service sooner or later, serve on 3 days; With ibuprofen modified release capsule group for matched group, the same day in menstrual period oral ibuprofen slow releasing capsule 30mg, 1 time/d, namely pain only stops using, being used in conjunction 3 menstrual cycle was 1 course for the treatment of, and observing time is 3 months, by comprehensive therapeutic effect, disease curative effect, the change of primary symptom and simultaneous phenomenon, and the change etc. of check result as erythrocyte sedimentation rate value of Binding experiment room carries out clinical observation to two kinds of these diseases of Drug therapy.

Whole process of the test arrangement is made a house call for 6 times, make a house call for 1st time and be arranged in case screening, informed consent postscript is signed patient, carry out corresponding inquiring, health check-up and lab testing, if patient meets inclusion criteria, a medicine numbering will be distributed in order, i.e. random number, and arrange to enter first month through cycle therapy; Make a house call for 2nd time after being arranged in treatment menstrual cycle, further consultation before menstrual cycle next time; Make a house call for 3rd time after being arranged in treatment two menstrual cycle, under further consultation before menstrual cycle successively, treatment 3 menstrual cycle are 1 course for the treatment of continuously; After drug withdrawal, follow up a case by regular visits to 3 months continuously, monthly to patient's telephone questionnaire once, the improvement of clinical symptoms and sign are detected, evaluate Drug safety and effectiveness.

(2) sample size

Selector closes and states the 80 cases of test case standard, often organizes each 40 examples.

(3) medicine and usage

1. medicine name

Trial drug: the present invention, thered is provided by Chinese medicine pharmacy of women and children hospital of Shandong institute of traditional Chinese medicine, prescription: each 10g of Radix Arnebiae (Radix Lithospermi), Herba Epimedii, Radix Polygalae, Radix Angelicae Sinensis, Herba Leonuri, Spica Prunellae, the Radix Astragali, Fructus Aurantii, Radix Rehmanniae Preparata, Ramulus Cinnamomi, Fructus Corni, Fructus Ligustri Lucidi, Sanguis Draxonis, Radix Curcumae, Radix Paeoniae Rubra, Flos Rosae Rugosae, Rhizoma Cyperi, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Caulis Spatholobi and Rhizoma Sparganii; Described external preparation comprises following crude drug: Radix Et Rhizoma Rhei, Radix Dipsaci, Rhizoma Cyperi, Radix Salviae Miltiorrhizae, Radix Clematidis, Rhizoma Corydalis, Ramulus Cinnamomi, Cortex Lycii, Herba Taxilli, Sanguis Draxonis, Radix Saposhnikoviae, Folium Artemisiae Argyi Flos Carthami, each 15g.

Control drug: ibuprofen modified release capsule, is produced by Sino-America Tianjin Shike Pharmaceutical Co., Ltd., authentication code: the accurate word H 10900089 of traditional Chinese medicines, batch number: 08110660, every 0.39, specification: 20/box.

2. test the course for the treatment of: being used in conjunction 3 menstrual cycle was 1 course for the treatment of, judged curative effect after observing 3 menstrual cycle.

3. drug combination: duration of test must not add with in relevant with treatment primary disease, Western medicine product and other means.

(2) tcm syndrome efficacy assessment standard (with reference to nimodipine method)

Integration before therapeutic index=N (treat front integration one and treat rear integration)/treatment) X%

The observation of curative effect of Herba Leonuri danggui sini decoction treatment cold coagulation blood scabies type dysmenorrhea

1. fully recover, each transference cure after treatment, syndrome integral therapeutic index >=95%;

2. effective, after treatment, each symptom obviously alleviates, syndrome integral therapeutic index >=70%, <95%;

3. effective, after treatment, each symptom alleviates to some extent, syndrome integral therapeutic index >=30%, <70%;

4 is invalid, and after treatment, each symptom increases the weight of without alleviating or having, syndrome integral therapeutic index≤30%;

Eight statistical analysiss and date processing

Statistical analysis plan: application SPSS13.0 statistical package, after homogeneity of variance is analyzed, measurement data compares employing t inspection, and enumeration data adopts x ²inspection, ranked data adopt rank test, compare and adopt paired t-test " (note: all represent mean with-x below) in group

Experiment: patient 80 example meeting inclusive criteria is collected in this clinical trial altogether, and patient dependence is good, and no one is lost to follow-up.

The present invention treats the observation of curative effect of qi depression to blood stasis dysmenorrhea

The comparison (n, %) of table 1 liang group patient therapeutic effect of syndrome

The comparison of two groups of patient's disease curative effects is used and is expanded inspection calculating, x ²=12.831, P=0.010, two groups of cure rates, obvious effective rate, the group difference of effective percentage, inefficiency, total effective rate all has statistical significance.

After table 2 liang group patient treatment, dysmenorrhea integral difference compares (-x ± s)

The difference of the comprehensive therapeutic effect between two groups before and after patient treatment calculates through the t inspection of two independent samples, and P<0.05, the two curative effect has statistical significance.

Compare in the group of table 3 liang group Patient Global curative effect

The comparison (-x ± s) of pain degree integration before and after table 3 liang group patient treatment

Group	n	(divide) before treatment	After treatment (dividing)	t	P
						Test group	40	9.28±2.693	5.25±2.801	11.063	0.000
Matched group	40	9.88±2.791	6.83±2.129	10.979	0.000

Calculate through paired t-test, P<0.001, before and after two groups of patient treatments, therapeutic effect of syndrome integral contrast has significant difference.

Table 4, two groups of pain relieving onset times compare (n/%)

Group	n	Invalid	30min	1h	1.5h	2
							Test group	40	2(5)	17(42.5)	9(22.5)	8(20)	4(10)
Matched group	40	3(7.5)	26(65)	10(25)	1(2.5)	0

Before and after table 5 liang group treatment, the hypogastralgia time compares (n)

L () calculates through the rank test of matched-pair design data, before and after test group treatment, the hypogastralgia time compares, Z=2.611, P=0.009; Before and after treatment of control group, the hypogastralgia time compares; Z=2.426, P=0.00, before and after two groups of treatments, the difference of hypogastralgia time all has statistical significance.

(2) under completely randomized design, the rank test of two groups of ordered set data calculates, Z=2.426, P=0.015, two groups of treatments

The rear hypogastralgia time compares, and group difference has statistical significance, and the average sum of ranks of test group and matched group is 35.30,45.70.

The comparison of table 6. liang group patient simultaneous phenomenon curative effect

After table 6 liang group treatment, simultaneous phenomenon improvement situation compares (n)

Calculating through separating inspection, comparing before and after test group treatment, x ²=12.614, P=0.047, difference has statistical significance: compare before and after treatment of control group, x ²=7.030, P=0.436, no significant difference.

The comparison of table 7 liang group patient secondary efficacy index

The comparison (-x ± s) of erythrocyte sedimentation rate value before and after table 7 liang group patient treatment

Before and after two groups of patient treatments, erythrocyte sedimentation rate value calculates through paired t-test, P<0.05, and the difference before and after treatment has statistical significance

1. safety detects: in treatment and observation process thereof, routine blood test, the two just routine examination before and after of the present invention group of patient treatment, electrocardiogram, hepatic and renal function all do not find obvious exception.

2. untoward reaction: in treatment and observation process thereof, do not have patient to tell any discomfort and allergic phenomena.

Discuss

Dysmenorrhea is one of modal disease of gynecological, and its incidence rate report differs, and account for 42% ~ 90%, wherein severe pain is through accounting for 18%.Dysmenorrhea is a disease that is long-term, easily recurrent exerbation, can accompany nausea and vomiting, dripping cold sweat, deadly cold hand and foot, very then faint, affect life and work more time serious, totally unfavorable to the physical and mental health of women.In treatment, the appearance of PGSI, the sickness rate of this disease is greatly reduced, ibuprofen modified release capsule has stronger antiinflammatory, pain relieving, refrigeration function, by suppressing prostaglandin synthetase, thus suppresses the synthesis of prostaglandin, produce anti-inflammatory analgesic effect, therefore ibuprofen modified release capsule is premenstruum, and use has the effect prevented irritation, using menstrual period has spasmolytic, analgesic activity, is characterized in that administration is easy, instant effect.But because its symptom mainly for its pain is eased pain, improve not good to simultaneous phenomenon, thoroughly can not cure dysmenorrhea, and because of side effect larger, can cause nausea, vomit, the gastrointestinal upset such as diarrhoea, also can cause stomatitis, dizziness, tinnitus, blurred vision, the untoward reaction such as erythra, therefore still can not think that oral ibuprofen slow releasing capsule is the Perfected process for the treatment of dysmenorrhea.Chinese medicine is started with by entirety, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs demonstrates obvious advantage.For " addiction blood " pathogenesis of dysmenorrhea, endocrine disturbance is main pathogeny, in conjunction with the modern pharmacological research achievement of Chinese medicine, explores traditional Chinese medical herbal treatment dysmenorrhea and has vast potential for future development.

Claims

1. treat the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type for one kind, it is characterized in that, in described Chinese medicine composition, oral preparations comprises following crude drug: Medulla Tetrapanacis, Herba Epimedii, Fructus Foeniculi, Radix Angelicae Sinensis, Herba Leonuri, Oletum Trogopterori, the Radix Astragali, Fructus Mori, Cortex Moutan, Cortex Cinnamomi, Fructus Rubi, Myrrha, Sanguis Draxonis, Radix Curcumae, Radix Paeoniae Rubra, Flos Rosae Rugosae, Rhizoma Cyperi, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Caulis Spatholobi and Rhizoma Sparganii; In described Chinese medicine composition, external preparation comprises following crude drug: Fructus Foeniculi, Fructus Cnidii, Eupolyphaga Seu Steleophaga, Radix Dipsaci, Herba Asari, Radix Salviae Miltiorrhizae, the Radix Linderae, Rhizoma Corydalis, Ramulus Cinnamomi, Folium Artemisiae Argyi, Fructus Toosendan Flos Carthami.

2. treat the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type according to claim 1, it is characterized in that, in described Chinese medicine composition, oral preparations comprises the crude drug of following parts by weight: Medulla Tetrapanacis 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Fructus Foeniculi 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Flos Rosae Rugosae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, in described Chinese medicine composition, external preparation comprises the crude drug of following parts by weight: Fructus Foeniculi 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, the Radix Linderae 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Fructus Toosendan 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami.

3. treat the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type according to claim 1, it is characterized in that, in described Chinese medicine composition, oral preparations comprises the crude drug of following parts by weight: Medulla Tetrapanacis 10 ~ 15 parts, Herba Epimedii 10 ~ 15 parts, Fructus Foeniculi 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Oletum Trogopterori 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Fructus Mori 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Flos Rosae Rugosae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, in described Chinese medicine composition, external preparation comprises the crude drug of following parts by weight: Fructus Foeniculi 10 ~ 15 parts, Fructus Cnidii 10 ~ 15 parts, Eupolyphaga Seu Steleophaga 10 ~ 15 parts, Radix Dipsaci 10 ~ 15 parts, Herba Asari 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, the Radix Linderae 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Fructus Toosendan 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami.

4. treat the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type according to claim 1, it is characterized in that, in described Chinese medicine composition, oral preparations comprises the crude drug of following parts by weight: Medulla Tetrapanacis 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Fructus Foeniculi 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Myrrha 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, Radix Curcumae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Flos Rosae Rugosae 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Rhizoma Sparganii 10 ~ 15 parts, in described Chinese medicine composition, external preparation comprises the crude drug of following parts by weight: Fructus Foeniculi 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, the Radix Linderae 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Ramulus Cinnamomi 10 ~ 15 parts, Folium Artemisiae Argyi 10 ~ 15 parts, Fructus Toosendan 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami.

5. as described in any one of Claims 1 to 4 item, treat a preparation method for the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type, it is characterized in that, the preparation process when oral preparations of described Chinese medicine composition is capsule is:

A. described crude drug is put into pulverizer grinding and sieving;

6. treat the preparation method of the oral capsule of the Chinese medicine composition of dysmenorrheal caused by qi stagnation and blood stasis according to claim 5, it is characterized in that, in described step a, described crude drug is put into after pulverizer is pulverized and cross 120 order dusting covers, the enable fine powder amount by 120 mesh sieves is reaching 20%, collects by the crude drug fine powder of 120 mesh sieves for subsequent use.

7. treat the preparation method of the oral capsule of the Chinese medicine composition of dysmenorrheal caused by qi stagnation and blood stasis according to claim 5, it is characterized in that, in described step b, coarseparticulate remaining after above-mentioned steps being sieved puts into ethanol, soak more than 2 hours, add respectively account for crude drug gross mass 8 times amount, 6 times amount ethanol heating extraction 2 times, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, one-tenth extractum stand for standby use.

8. treat the preparation method of the oral capsule of the Chinese medicine composition of dysmenorrheal caused by qi stagnation and blood stasis according to claim 5, it is characterized in that, in described step c, the medicinal residues that above-mentioned ethanol extraction is crossed are added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, one-tenth extractum stand for standby use.

9. treat the preparation method of the oral capsule of the Chinese medicine composition of dysmenorrheal caused by qi stagnation and blood stasis according to claim 5, it is characterized in that, in described steps d, extract extractum by above-mentioned 4 times to merge, when concentrating under reduced pressure relative density is 80 DEG C 1.28 pasty state, reclaim ethanol, gained pasty state is passed into spray dryer and carries out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 80 DEG C, obtains crude drug medicated powder; After being mixed with crude drug medicated powder by the crude drug fine powder obtained after sieving, be in harmonious proportion Mel, be twisted into pill.

10. as described in any one of Claims 1 to 4 item, treat the preparation method of the Chinese medicine composition of dysmenorrheal caused by qi stagnation and blood stasis for one kind, it is characterized in that, the preparation process when external preparation of described Chinese medicine composition is enema is: put into except Folium Artemisiae Argyi, Rhizoma Cyperi and Sanguis Draxonis by described crude drug after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 30%, collects by the crude drug fine powder of 100 mesh sieves for subsequent use; Again the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; In described steps d, crystallization of Folium Artemisiae Argyi, Rhizoma Cyperi and Sanguis Draxonis distillation being vaporized to obtain, is dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.46, stir evenly after adding the crystalline powder of fine powder and the distillation of sieving, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.50 extractum, heating be condensed into pasty state, ultraviolet virus killing after use.