CN110193076A - A kind of Chinese medicine composition and preparation for treating hypertension, hyperlipidemia, high blood viscosity - Google Patents

A kind of Chinese medicine composition and preparation for treating hypertension, hyperlipidemia, high blood viscosity Download PDF

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Publication number
CN110193076A
CN110193076A CN201910632953.2A CN201910632953A CN110193076A CN 110193076 A CN110193076 A CN 110193076A CN 201910632953 A CN201910632953 A CN 201910632953A CN 110193076 A CN110193076 A CN 110193076A
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parts
rhizoma
radix
hyperlipidemia
chinese medicine
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吴文喜
吴创礼
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吴文喜
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/648Myriapods, e.g. centipedes or millipedes
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

The present invention, which discloses, a kind of treats hypertension, hyperlipidemia, the Chinese medicine composition of high blood viscosity, by pueraria lobata, Radix Astragali, hawthorn, cassia seed, Prunella vulgaris, stir-baked CORTEX EUCOMMIAE, herba taxilli, radix scutellariae, the coptis, lotus nut, radix aconiti lateralis preparata, Chinese ephedra, asarum, ramulus cinnamomi, rhizoma zingiberis, radix saposhnikoviae, scorpio, centipede, Herba Cistanches, Radix Salviae Miltiorrhizae, tuber fleeceflower stem, rhizoma atractylodis, rheum officinale, rhizoma cyperi, Rhizoma Chuanxiong, Divine Comedy, stir-baked FRUCTUS GARDENIAE, Cortex Phellodendri, Radix Glycyrrhizae, rhizoma anemarrhenae, Rhizoma Atractylodis Macrocephalae, the raw materials such as rhizoma alismatis are prepared, with Shengyang Zhixie, invigorating qi for strengthening superficies, promoting blood circulation, it is clearing heat and detoxicating, warming spleen and stomach for dispelling cold, it removes obstruction in channels to relieve pain, it is drying damp and strengthening spleen, the effects of The flat liver of heat-clearing, effectively treatment hypertension, hyperlipidemia, high blood viscosity and both the above or three kinds of symptoms symptoms such as concurrently.Chinese medicine composition of the invention can be made into several formulations, takes, is easy to carry, and formula is scientific and reasonable for Chinese medicine composition, and Small side effects, preparation method is simple, and preparation cost is low, can mitigate body and the financial burden of patient significantly, have very big promotional value.

Description

A kind of Chinese medicine composition and preparation for treating hypertension, hyperlipidemia, high blood viscosity
[technical field]
The application belongs to medicines and health protection field, and in particular to it is a kind of treat hypertension, hyperlipidemia, high blood viscosity Chinese medicine composition and Preparation.
[background technique]
Hypertension is to continue the disease of hyperpiesia, can cause the diseases such as apoplexy, heart disease, hemangioma, kidney failure.It is slow by onset Urgency and disease progression can be divided into slow-moving type and rapidly progressive type, common with slow-moving type.Benign hypertension show as common headache, It is dizzy;When excited, blood pressure can hurried raising, show as severe headache, vision disorder, Nausea and vomiting, twitch, or even dusk Fan, transient hemiplegia, aphasia etc..This brings greatly pain and burden to the life of patient.
Blood lipid is the general name of contained lipoids in blood.It mainly include cholesterol, triglyceride (i.e. neutral fats in blood lipid Fat), phosphatide, fatty acid etc..Blood lipid, which increases, is hyperlipidemia, but is commonly referred to as hyperlipidemia in clinical hyperlipidemia, and it is solid to show as high gallbladder Alcoholemia, hypertriglyceridemia or both have concurrently, are clinically divided into two classes: 1. primary, rare, and it is disorderly to belong to heredity lipid metaboli Random disease;2. it is secondary, the bad diabetes of control are common in, are drunk, hypothyroidism, nephrotic syndrome, Rend dialysis, Kidney transplant, biliary obstruction, oral contraceptive etc..
High blood viscosity is clinically commonly referred to as hypercoagulable blood, is the pathology synthesis increased with blood viscosity mainly to show Sign, after blood viscosity increases, blood resistance is increased, flowing slowly causes blood-perfusion of tissues amount to substantially reduce and make the devices such as heart and brain Official generates a series of performances of ischemic, anoxic, such as uncomfortable in chest, pectoralgia, headache, dizziness, tinnitus, dysopia, numb limb, swelling Thrombus is formed Deng, serious person, causes cerebral atherosclerosis, hypertension, coronary heart disease, myocardial infarction, apoplexy etc. a series of serious Disease.
In present market production and the drug for using treatment hypertension, blood lipid, blood viscous, three can only temporarily be controlled by taking Western medicine High target, but cannot fundamentally cure, and need to take all the life, it is larger to human body side effect, category is treated with this medicine Yu Zhibiao does not control root, and the pain of heavy financial burden and Long-term taking medicine is brought to patient, so in place of there are many deficiencies, nothing Method reaches treatment optimum efficiency.
Inventor uses traditional Chinese medical herbal treatment above-mentioned symptom, and emphasis centralizing qi adjusts viscera function, cooperateed with viscera function Effect, endocrine is normal adjusting, and here it is the skills and essence of the diseases such as radical cure hypertension, hyperlipidemia, high blood viscosity, from entirety It adjusts, search for the primary cause of disease in treatment, can effectively adjust the function balance between each system of body, Small side effects are suitble to be used for a long time.
[summary of the invention]
Present invention is generally directed in existing drug, treat above-mentioned " three high " in the presence of the problems such as table does not control root is controlled, a kind of warp is provided The verifying of clinical induction and conclusion, treatment hypertension, hyperlipidemia, high blood viscosity Chinese medicine preparation, using helping sun to consolidate principle, emphasis righting Gas adjusts viscera function, is acted synergistically with viscera function, normal to adjust endocrine, eradicates hypertension, hyperlipidemia, high blood viscosity Etc. diseases, so providing a kind of Chinese medicine composition for treating hypertension, hyperlipidemia, high blood viscosity.Therapeutic effect is significant, it can be achieved that mark Originally simultaneous to control, it is securely and reliably, without any side effects.
To achieve the goals above, The technical solution adopted by the invention is as follows:
Treatment hypertension of the invention, hyperlipidemia, high blood viscosity Chinese medicine composition, be prepared by the raw material of following parts by weight: 0.1-3 parts of pueraria lobata, 1-3 parts of Radix Astragali, 0.5-3 parts of hawthorn, 1-2 parts of cassia seed, 1-3 parts of Prunella vulgaris, 1-2 parts of stir-baked CORTEX EUCOMMIAE, herba taxilli 0.5-3 parts, 0.3-2 parts of radix scutellariae, 1-2 parts of the coptis, 0.1-1 parts of lotus nut, 0.1-1 parts of radix aconiti lateralis preparata, 0.2-1.5 parts of Chinese ephedra, asarum 0.1-1 parts, 1-3 parts of ramulus cinnamomi, 1-2 parts of rhizoma zingiberis, 0.5-1 parts of radix saposhnikoviae, 0.1-1 parts of scorpio, 0.1-1 parts of centipede, 1-3 parts of Herba Cistanches, 0.5-2 parts of Radix Salviae Miltiorrhizae, 1-3 parts of tuber fleeceflower stem, 1-2 parts of rhizoma atractylodis, 0.1-1.5 parts of rheum officinale, 0.5-1 parts of rhizoma cyperi, 1-1.5 parts of Rhizoma Chuanxiong, Divine Comedy 1-2 parts, 0.5-1 parts of stir-baked FRUCTUS GARDENIAE, 0.5-1.5 parts of Cortex Phellodendri, 0.1-2 parts of Radix Glycyrrhizae, 0.2-1.3 parts of rhizoma anemarrhenae, 1-3 parts of Rhizoma Atractylodis Macrocephalae, rhizoma alismatis 0.5-2 parts.
Preferably, it is prepared by the raw material of following parts by weight: 0.5-2 parts of pueraria lobata, 1.5-2 parts of Radix Astragali, hawthorn 1.5-2.5 Part, 1.2-1.8 parts of cassia seed, 1.5-2.5 parts of Prunella vulgaris, 1.2-1.8 parts of stir-baked CORTEX EUCOMMIAE, 1.5-2.5 parts of herba taxilli, radix scutellariae 0.6- 1.5 parts, 1.2-1.8 parts of the coptis, 0.3-0.7 parts of lotus nut, 0.3-0.7 parts of radix aconiti lateralis preparata, 0.5-1 parts of Chinese ephedra, 0.4-0.8 parts of asarum, 1.5-2.5 parts of ramulus cinnamomi, 1.2-1.8 parts of rhizoma zingiberis, 0.6-0.8 parts of radix saposhnikoviae, 0.3-0.7 parts of scorpio, 0.3-0.7 parts of centipede, Herba Cistanches 1.5-2.5 parts, 1-1.5 parts of Radix Salviae Miltiorrhizae, 1.5-2.5 parts of tuber fleeceflower stem, 1.2-1.8 parts of rhizoma atractylodis, 0.5-1 parts of rheum officinale, rhizoma cyperi 0.6-0.8 Part, 0.8-1.2 parts of Cortex Phellodendri, 0.5-1.5 parts of Radix Glycyrrhizae, is known 1.2-1.4 parts of Rhizoma Chuanxiong, 1.2-1.8 parts of Divine Comedy, 0.6-0.8 parts of stir-baked FRUCTUS GARDENIAE 0.5-1 parts female, 1.5-2.5 parts of Rhizoma Atractylodis Macrocephalae, 1-1.5 parts of rhizoma alismatis.
Preferably, it is prepared by the raw material of following parts by weight: 1.5 parts of pueraria lobata, 1.8 parts of Radix Astragali, 2 parts of hawthorn, cassia seed 1.5 parts, 2 parts of Prunella vulgaris, 1.5 parts of stir-baked CORTEX EUCOMMIAE, 2 parts of herba taxilli, 1 part of radix scutellariae, 1.5 parts of the coptis, 0.5 part of lotus nut, radix aconiti lateralis preparata 0.5 Part, 0.8 part of Chinese ephedra, 0.6 part of asarum, 2 parts of ramulus cinnamomi, 1.5 parts of rhizoma zingiberis, windproof 0.7 part, 0.5 part of scorpio, 0.5 part of centipede, Herba Cistanches 2 parts, 1.2 parts of Radix Salviae Miltiorrhizae, 2 parts of tuber fleeceflower stem, 1.5 parts of rhizoma atractylodis, 0.7 part of rheum officinale, 0.7 part of rhizoma cyperi, 1.2 parts of Rhizoma Chuanxiong, 1.6 parts of Divine Comedy, stir-fry 0.7 part of cape jasmine, 1 part of Cortex Phellodendri, 1 part of Radix Glycyrrhizae, 0.8 part of rhizoma anemarrhenae, 2 parts of Rhizoma Atractylodis Macrocephalae, 1.2 parts of rhizoma alismatis.
Preferably, the active constituent of the Chinese medicine composition is made of being prepared by the following method:
Whole medicinal materials are taken, are placed in pressure pan, and 3-5 times of water for being equivalent to medicinal material total weight is added, are forced into tank with steam Interior pressure is 0.4-1.5MPa, and controlling temperature of charge in tank is 120-180 DEG C, material in agitator tank, after steam pressure 1.5-5h, from It is so cooled to room temperature, takes the filtrate in tank, filtrate is placed in vacuum freeze drier and is freeze-dried, obtain 70-78 DEG C When relative density be 1.05-1.25 clear cream, obtain active constituent.
Preferably, when filtrate being carried out vacuum freeze drying, first the pre-freeze 1-1.5h at -10 DEG C to -15 DEG C, is then arranged The vacuum degree of vacuum freeze drier is 5-100Pa, and microwave heating makes filtrate temperature DEG C gradually rise to 0 from -10 DEG C to -15 DEG C, make the free water sublimate in filtrate, sublimation time 1.5-2.5h, it is to be concentrated after filtrate when ice is not present, microwave heating, Filtrate temperature after making concentration, which rises rapidly, to be parsed, and maximum temperature control is kept at 15-18 DEG C, and in this temperature range 0.5-1h obtains the clear cream that relative density at 70-78 DEG C is 1.05-1.25.
Various systems can also be made with pharmaceutically acceptable carrier combination in herbal composite of the present invention Agent, such as tablet, capsule, oral solution, syrup, mixture, granule, pill.
Pharmaceutically acceptable carrier of the invention includes but is not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive: purified water, ethyl alcohol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrating agent: starch, sodium carboxymethyl starch, cellulose derivative, crospovidone etc..
Lubricant: magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent: water, ethyl alcohol, glycerol, propylene glycol, liquid paraffin, vegetable oil etc..
Corrigent: sucrose, monosaccharide, aromatic, xylitol, oligofructose etc..
Preservative: benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
Method 1: tablet
Gained active constituent is taken, tablet is added and often uses auxiliary material, routinely production method is prepared into Tablets.
Above-mentioned tablet often includes one of diluent, wetting agent, adhesive, disintegrating agent, lubricant or whole with auxiliary material.
Method 2: capsule
Gained active constituent is taken, capsule is added and often uses auxiliary material, routinely production method is prepared into capsule of the present invention.
Above-mentioned capsule often includes one of diluent, wetting agent, adhesive, disintegrating agent, lubricant or whole with auxiliary material.
Method 3: syrup
Gained active constituent is taken, syrup is added and often uses auxiliary material, routinely production method is prepared into syrup of the present invention.
Above-mentioned syrup often includes one of corrigent, preservative, cosolvent or whole with auxiliary material.
Method 4: mixture
Gained active constituent is taken, mixture is added and often uses auxiliary material, routinely production method is prepared into mixture of the present invention.
Above-mentioned mixture often includes one of corrigent, preservative or whole with auxiliary material.
Method 5: oral solution
Gained active constituent is taken, dissolution after-purification, concentration are added oral solution and often use auxiliary material, and routinely production method is prepared into this Invention oral solution.
Above-mentioned oral solution often includes one of corrigent, preservative, cosolvent or whole with auxiliary material.
Method 6: granule
Gained active constituent is taken, granule is added and often uses auxiliary material, routinely production method is prepared into granule of the present invention.
Above-mentioned granule often includes one of diluent, wetting agent, adhesive, disintegrating agent, lubricant or whole with auxiliary material.
Method 7: pill
Gained active constituent is taken, edible gelatin is added, maltose, honey, cornstarch, routinely production method is prepared into this hair Bright pill.
It is the crude drug source of herbal composite of the present invention below:
Pueraria lobata, for legume pueraria lobata Pueraria lobata(Willd.) Ohwi or sweet kudzu Pueraria thomsonii Benth. dry root.It is sweet, pungent, it is cool.Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid, promoting eruption, Shengyang Zhixie.For fever caused by exogenous pathogens headache, rigid neck and back Bitterly, thirsty, it quenches one's thirst, measles without adequate eruption, hot dysentery, diarrhea, hypertension neck pain.
Radix Astragali, the entitled Leguminosae of Latin, alias astragali, northern alpine yarrow, Astragalus, be leguminous herbaceous plant's astragalus mongolicus, The dry root of Astragalus membranacus.It is warm-natured, sweet in flavor, slightly sweet.With with invigorating qi, consolidating exterior, promoting urination and detoxification, apocenosis, the work of expelling pus and promoting granulation With.
Hawthorn, be rosaceous plant large-fruited Chinese hawthorn Crataegus pinnatifida Bge.var.major N.E.Br. or The dry mature fruit of hawthorn Crataegus pinnatifida Bge..Sour, sweet, tepor.With food digesting stomach fortifying, promoting blood circulationization It becomes silted up, the function of convergence and dysentery.Not for meat accumulation phlegm retention, feeling of fullness acid regurgitation, dysentery intestines wind, pain in the loins hernia, postpartum postpartum abdominal pain, lochia To the greatest extent, pediatric milk food stagnation.
Cassia seed is legume cassia Cassia obtusifolia L.'s or little cassia tora Cassia tora L. Dry mature seed.It is sweet, bitter, salty, it is slightly cold.Heat-clearing improving eyesight, relax bowel and defecation.For the puckery pain of hot eyes, the more tears of photophobia, headache and dizziness, Mesh is secretly unknown, constipation.
Prunella vulgaris is the drying fruit ear of Lamiaceae plant Prunella vulgaris Prunella vulgaris L..It is pungent, bitter, it trembles with fear.Clearly Fire, improving eyesight, dissipating bind, detumescence.For red eye, swell pain, eyeball night pain, headache and dizziness, scrofula, goiter, acute mastitis swelling and pain;Goitre Greatly, scrofula, the proliferation of mammary gland, hypertension.
Cortex Eucommiae is the dry bark of Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv..Sweet, warm.Nourishing liver and kidney, Strengthening the bones and muscles, miscarriage prevention.For lumbago due to the kidney deficiency, muscles and bones is powerless, blood leaking in gestation, threatened abortion, hypertension.
Herba taxilli is the dry zone leaf of Loranthaceae plant herba taxilli Taxillus chinensis (DC.) Danser Stem branch.Bitter, sweet, flat.Nourishing liver and kidney, strengthening bones and muscles, dispelling wind and dampness, miscarriage prevention member.For rheumatic arthralgia, soreness and weakness of waist and knees, muscles and bones is powerless, metrorrhagia and metrostaxis Through more, blood leaking in gestation, threatened abortion;Hypertension.
Radix scutellariae, the entitled Scutellaria baicalensis Georgi of Latin are Labiatae, radix scutellariae platymiscium.Expelling pathogenic factors from muscles and skin It brings down a fever, promotes the production of body fluid, promoting eruption, Shengyang Zhixie.Hardship is trembled with fear.Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid, promoting eruption, Shengyang Zhixie.For fever caused by exogenous pathogens headache, item The strong pain of back, it is thirsty, it quenches one's thirst, measles without adequate eruption, hot dysentery, diarrhea;Hypertension neck pain.
The coptis, scientific name Coptis chinensis Franch., alias taste connects, river connects, Rhizoma Coptidis, belongs to Ranunculaceae, the coptis Belong to herbaceos perennial.It is cold, it is bitter.Heat-clearing and damp-drying drug, purging fire for removing toxin.For damp and hot feeling of fullness, acid regurgitation, dysentery, jaundice, high fever are vomitted Coma, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache are quenched one's thirst, carbuncle swells furunculosis;Eczema, wet sore, ear canal stream are controlled outside Purulence.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach anti-vomiting.It is mutually tied for fever and chills, damp and hot middle resistance, Feeling of fullness vomiting.Cornel coptis is relaxed liver anti-vomiting.For liver-stomach disharmony, acid regurgitation is vomitted.
Lotus nut is the green radicle among the mature seed of nymphaeaceae plant lotus Nelumbo nucifera Gaertn.. Hardship is trembled with fear.Clearing away the heart fire and tranquillizing, restoring normal coordination between heart and kidney, unsmoothing the sperm and stopping bleeding.For the invasion of pericardium by heat, coma and delirium, breakdown of the normal physiological coordination between the heart and the kidney, insomnia spermatorrhea, blood-head It spits blood.
Radix aconiti lateralis preparata is the processed goods of the sub- root of ranunculaceae plant rhizome of Chinese monkshood Aconitum carmichaeli Debx..Through salt Stain, water, which are floated, boiled, frying etc. after methods process, reduces toxicity, claims " radix aconiti lateralis preparata ".It is pungent, sweet, big heat;It is toxic.Recuperating depleted yang, mends fire supporing yang, By wind-cold damp pathogen.It collapses for yang depletion, cold weak pulse of limb, impotence, palace cold, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold sensation of the genitalia oedema, outside the deficiency of yang Sense, numbness and ache of cold dampness.
Chinese ephedra is Ephedraceae plant ephedra sinica Ephedra sinica Stapf, epheday intermedia Ephedra intermedia The drying herbaceous stem stem of Schrenk et C. A. Mey. or ephedra equisetina Ephedra equisetina Bge..Pungent, slight bitter, Temperature.Sweating cold dispelling, freeings lung and relieving asthma, inducing diuresis for removing edema.It is uncomfortable in chest to breath with cough for anemofrigid cold, geomantic omen edema;Bronchial asthma.Sweet fiber crops Yellow moistening lung to arrest cough.It is chiefly used in table disease to have solved, asthma and cough.
Asarum is aristolochiaceae plant Herba Asari Asarum heterotropoides Fr. Schmidt Var.mandshuricum(Maxim.) Kitag., Seoul asarum Asarum sieboldii Miq. var. seoulense The drying herb of Nakai or asarum sieboldii Asarum sieboldii Miq..It is acrid in flavour and warm in nature.Expelling wind and clearing away cold, sensible analgesic, warm lung Drink.For anemofrigid cold, have a headache, toothache, nasosinusitis of having a stuffy nose, rheumatic arthralgia, sputum cough.
Ramulus cinnamomi is the dry twig of lauraceae plant cortex cinnamomi Cinnamomum cassia Presl.Acrid, sweet, warm.Sweating solution Flesh, warming meridian, help yang gas, flat and gas.For anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, arthralgia, phlegm retention, water It is swollen, palpitaition, renal mass.
Rhizoma zingiberis is the dry rhizome of zingiber Zingiber officinale Rosc..It is pungent, hot.Rhizoma zingiberis middle benefit gas dissipates It is cold, recover Yang and smooth venation, eliminating dampness dissolving phlegm.For coldness and pain in the epigastrium, vomiting and diarrhea, cold weak pulse of limb, sputum cough.
Radix saposhnikoviae is the dry of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk. Dry.Acrid, sweet, warm.Inducing diaphoresis to dispel wind wins wet, relieving convulsion.For cold headache, rheumatic arthralgia, rubella itch, tetanus.
Scorpio is the hirudo leech of Buthidae animal buthus martensii Karscs Buthus martensii Karsch.It is pungent, it puts down;It is toxic. Relieve the wind syndrome antispastic, dispersing pathogen accumulation are removed obstruction in channels to relieve pain.For child convulsion, spasm of twitching, middle air port is askew, hemiplegia, tetanus, wind Wet stupid numbness, migraine and general headache, sore, scrofula.
Centipede is Scolopendridae animal Scolopendpa Subspinipes Mutilans L. KOCH Scolopendra subspinipes mutilans L. Koch's Hirudo leech.It is acrid in flavour and warm in nature;It is toxic.Relieve the wind syndrome antispastic, function poison dissipating bind, removes obstruction in channels to relieve pain.For child convulsion, spasm of twitching, middle air port is askew, Hemiplegia, tetanus, rheumatoid arthritis stubborn, sore, scrofula, venomous snake bite.
Herba Cistanches are the meat of the dry zone scale leaf of orobanchaceae plant cistanche Cistanche deserticola Y.C.Ma Matter stem.It is sweet, salty, temperature.Kidney-replenishing, benefiting essence-blood, relax bowel and defecation.Infertile for impotence, soreness and weakness of waist and knees, muscles and bones is powerless, and intestinal dryness is just It is secret.
Radix Salviae Miltiorrhizae is the dry root and rhizome of Lamiaceae plant Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Hardship, it is slightly cold. Converge to heart and liver channels.It is inducing meastruation to relieve menalgia with promoting blood circulation, relieving restlessness and restlessness, the effect of cool blood to disappear carbuncle.For chest impediment and cardialgia, the stomach duct and abdomen side of body Bitterly, lump in the abdomen lump in the abdomen is gathered, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhea menostasis, sore swell and ache curative.
Tuber fleeceflower stem is the rattan or leaf bine stem of polygonum multiflorum thunb.Sweet slight bitter is put down.Can nourishing heart, calm the nerves, dredging collateral dispels Wind.Control insomnia, internal lesion caused by overexertion, hidrosis, deficiency of blood bodily pain, ulcer, scrofula, wind sore scabies tinea.
Rhizoma atractylodis are composite family [WTBX Atractylodes Lancea (Thunb.) DC. herbaceos perennial, with root Stem is used as medicine.It is pungent, bitter, temperature.Returns spleen, stomach, Liver Channel.Have the effects that drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.For abdominal fullness and distention, let out Water pouring is swollen, tinea pedis Wei lame, rheumatic arthralgia, anemofrigid cold, yctalopia.
Rheum officinale is polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Maxim Rheum tanguticum Maxim. ex Balf.Or Rheum officinale Rheum officinale Baill.Drying root and rhizome.Hardship is trembled with fear.It purges heat logical Intestines, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow.For real heat constipation, stagnate abdominal pain, and dysentery is not well, jaundice with damp-heat pathogen, blood-head tells nosebleed, hot eyes, pharynx Swollen, abdominalgia with intestinal abscess, carbuncle swells furunculosis, blood stasis closed, traumatic injury controls scald outside;Upper gastrointestinal bleeding.Rheum palmatum (processed with wine) is apt on clear Burnt noxious heat in the blood system.For hot eyes pharynx swelling, gingivitis.Prepared RADIX ET RHIZOMA RHEI, which rushes down, to be exerted oneself to delay, purging fire for removing toxin.For pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI Cooling blood and removing stasis hemostasis.There is stasis of blood haemorrhage for blood-head.
Rhizoma cyperi is the dry rhizome of sedge nutgrass flatsedge Cyperus rotundus L..Pungent, slight bitter, micro- sweet and neutral. Promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, chest gastral cavity ruffian, cold hernia stomachache, breast Distending pain, irregular menstruation, amenorrhea and algomenorrhea.
Rhizoma Chuanxiong, scientific name Ligusticum chuanxiong hort are acrid in flavour and warm in nature.Promote breath and open depression, dispels that wind-dryness is wet, and promoting blood circulation stops Bitterly.It is dizzy to control air-cooled headache rotation, hypochondriac pain abdomen pain, arthritis muscle contraction, menostasis, difficult labour, postpartum stasis block pain, ulcer sores.For menstruation It is uncomfortable, amenorrhea and algomenorrhea, lump in the abdomen abdominal pain, pricking pain in the chest, tumbling and swelling, headache, rheumatic arthralgia.
Divine Comedy is after the medicines such as polygonum flaccidum, sweet wormwood, almond are added flour or wheat bran mixes, it is fermented made of herbal leaven.Gan Xin, Temperature.Strengthening the spleen and stomach, in the tune that helps digestion.Control retention of food and drink, feeling of stuffiness in chest abdominal distension, vomiting dysentery, postpartum blood stasis abdominal pain, the big hard product of children's abdomen.
Stir-baked FRUCTUS GARDENIAE is the dry mature fruit of madder wort cape jasmine Gardenia jasminoides Ellis, root It can also be used as medicine.Hardship is trembled with fear.Fruit: purging intense heat relieving restlessness, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body.For Vexed, jaundice and reddish urine, blood strangury is puckery Bitterly, blood-head tells nosebleed, red eye, swell pain, pathogenic fire,toxin and furuncles;Bruise pain is controlled outside.
Cortex Phellodendri is rutaceae wampee Phellodendron chinense Schneid. or cork tree The dry bark of Phellodendron amurense Rupr..Hardship is trembled with fear.Heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment.For Damp-heat dysentery, jaundice, leukorrhagia, heat gonorrhea, tinea pedis, hectic fever due to yin labor heat, night sweat, spermatorrhea, sore swollen toxin, eczema itch.Stir-baked CORTEX PHELLODENDRI with salt solution enriching yin Fall fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.
Radix Glycyrrhizae is glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza The dry root of inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..Sweet and neutral.It invigorates the spleen and benefits qi, heat-clearing solution Poison, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, stomach duct and abdomen, four Limb contraction urgency pain, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
Rhizoma anemarrhenae is the dry rhizome of liliaceae plant Anemarrhena asphodeloides Bunge..Bitter, It is sweet, it trembles with fear.Clearing heat-fire, fluid dryness.For fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, lung-heat type cough, osteopyrexia and fever, Heat Diabetes, intestinal dryness Constipation.
Rhizoma Atractylodis Macrocephalae is the herbaceous plant of compositae plant Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz., with rhizome It is used as medicine.Bitter, sweet, warm.Returns spleen, stomach meridian.Have the effects that strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention.For spleen eating less, abdomen Swollen diarrhea, phlegm retention anti-dazzle nervous, indigestion, oedema, spontaneous perspiration, threatened abortion.
Rhizoma alismatis is the dry tuber of Notes On Alism At Aceae rhizoma alismatis Alisma orientalis (Sam.) Juzep..It is sweet, it trembles with fear. Diuresis, clearing away damp-heat.For difficult urination, edema swelling, oliguria of having loose bowels, phlegmatic vertigo, puckery pain of heat gonorrhea;Hyperlipidemia.
The main reason for hypertension chronic diseases is that long-term gallbladder channel and dai channel are obstructed, cause in point must dysfunction, internal organs Functional disturbance, will slowly generate hypertension and some other chronic diseases, we treat hypertension and focus on righting Gas, degrading the channel, tonifying yin sun, it is turbid to rush down phlegm, adjusts viscera function, it is normal to adjust endocrine with recovery viscera function, various functions Normally, high blood pressure disease will Lock-out.Inventor treats the diseases such as hypertension, hyperlipidemia and high blood viscosity from ancestors, is apt to In dialectical medication, dialectical as just before going into battle, medication is such as used military forces, flexible medication, and when the one's elder of inventor prescribes, usually double medicines are simultaneously Book, two medicine compatible use of implied meaning, during which plays coordinative role person, has the side effect that mutually disappears, specially takes its chief, has interaction to produce Raw, special-effect is all known as to medicine, and it is drug in pairs, the essence of actually many small sides and recipe, hair that surface, which is seen, The one's elder of bright people uses it to medicine, and entitled medication treats chronic disease and focus on centralizing qi, degrading the channel, tonifying yin actually with side Sun, turbid, the ingenious compatibility Chinese medicine that rushes down phlegm by monarch, minister, help, pharmacological function are made to arrange in pairs or groups, and here it is the skill of name medical drugs and essence.
Inventor ancestors practise medicine experience on the basis of, in conjunction with Traditional Chinese Medicine Coryza Treated by Syndrome Differentiation and modern pharmacological research at Fruit compares multiple formulations by many years development test, obtain with Shengyang Zhixie, invigorating qi for strengthening superficies, promoting blood circulation, it is clearing heat and detoxicating, Warming spleen and stomach for dispelling cold, remove obstruction in channels to relieve pain, be drying damp and strengthening spleen, The flat liver of heat-clearing the effects of Chinese medicine composition.Chinese medicine composition of the invention is to fry Cortex Eucommiae, pueraria lobata, herba taxilli, radix scutellariae, rhizoma alismatis be monarch drug in a prescription, can strengthening the bones and muscles, nourishing liver and kidney, Shengyang Zhixie, dispelling wind and relieving convulsion, be used for hypertension And hypertension neck pain.Using radix aconiti lateralis preparata, asarum, scorpio, centipede, Radix Salviae Miltiorrhizae, Chinese ephedra, tuber fleeceflower stem, rheum officinale, Rhizoma Chuanxiong as ministerial drug, Radix aconiti lateralis preparata, asarum expelling wind and clearing away cold, sensible analgesic;Scorpio, centipede relieve the wind syndrome antispastic, function poison dissipating bind are removed obstruction in channels to relieve pain;Radix Salviae Miltiorrhizae promoting blood circulation is dispelled The stasis of blood, it is inducing meastruation to relieve menalgia;Tuber fleeceflower stem tranquilizing the mind, dredging collateral;Rheum officinale purges heat logical intestines, dispelling stasis of blood and stimulating the menstrual flow;Rhizoma Chuanxiong promote breath and open depression, it is wet to dispel wind-dryness, living Blood and relieving pain;Chinese ephedra freeings lung and relieving asthma, inducing diuresis for removing edema;Above-mentioned ministerial drug can principal drug assistance activating microcirculation and removing stasis medicinal, with the function of principal drug assistance promoting blood circulation and stopping pain.With Herba Cistanches, Radix Astragali, cassia seed, the coptis, ramulus cinnamomi, rhizoma zingiberis, radix saposhnikoviae, rhizoma cyperi, Cortex Phellodendri, rhizoma anemarrhenae, Rhizoma Atractylodis Macrocephalae be adjutant, Rhizoma Atractylodis Macrocephalae, Herba Cistanches, Radix Astragali invigorating qi for strengthening superficies, kidney-replenishing, diuretic and maintain drug;Cassia seed heat-clearing improving eyesight;Cortex Phellodendri, rhizoma anemarrhenae, the coptis, rhizoma zingiberis, Rhizoma Atractylodis Macrocephalae heat-clearing and damp-drying drug, Purging fire for removing toxin;Ramulus cinnamomi warming meridian, helps yang transforming qi;Windproof inducing diaphoresis to dispel wind;Rhizoma cyperi promoting qi circulation and removing obstruction in the collateral.It is strong that adjutant carries out qi and blood, Principal drug assistance and the promoting the circulation of qi of ministerial drug promoting blood circulation to remove blood stasis can be helped and assistant makes its blood-activating and qi-promoting too qi and blood is lost.It is withered with hawthorn, summer Grass, lotus nut, Divine Comedy, stir-baked FRUCTUS GARDENIAE, Radix Glycyrrhizae are to make medicine, calming the liver and benefiting the lungs, and dispelling wind-heat is invigorated the spleen and benefited qi, clearing away the heart fire and tranquillizing, coordinating the drug actions of a prescription. The effects of Shengyang Zhixie, clearing heat and detoxicating, warming spleen and stomach for dispelling cold, promoting blood circulation, inducing meastruation to relieve menalgia, The flat liver of heat-clearing, is played altogether by full side, effectively treats Hypertension, hyperlipidemia, high blood viscosity and both the above or three kinds of symptoms symptoms such as concurrently.
In conclusion by adopting the above-described technical solution, the beneficial effects of the present invention are:
1, Chinese medicine composition of the invention and its preparation are prepared by several kinds of Chinese medicinal materials, and safety is mild, to pair nontoxic to the human body Effect has Shengyang Zhixie, invigorating qi for strengthening superficies, promoting blood circulation, clearing heat and detoxicating, warming spleen and stomach for dispelling cold, removes obstruction in channels to relieve pain, is drying damp and strengthening spleen, heat-clearing The effects of calming the liver.Stir-baked CORTEX EUCOMMIAE, pueraria lobata, herba taxilli, radix scutellariae, rhizoma alismatis are monarch drug in a prescription, can strengthening the bones and muscles, nourishing liver and kidney, Shengyang Zhixie, relieve the wind syndrome it is fixed It is frightened, it promotes blood circulation, is used for hypertension and hypertension neck pain;Radix aconiti lateralis preparata, asarum expelling wind and clearing away cold, sensible analgesic;Entirely Scorpion, centipede relieve the wind syndrome antispastic, function poison dissipating bind are removed obstruction in channels to relieve pain;Radix Salviae Miltiorrhizae promoting blood circulation, it is inducing meastruation to relieve menalgia;Tuber fleeceflower stem tranquilizing the mind, dredging collateral;Rheum officinale Purge heat logical intestines, dispelling stasis of blood and stimulating the menstrual flow;Rhizoma Chuanxiong promote breath and open depression, it is wet to dispel wind-dryness, promoting blood circulation and stopping pain;Chinese ephedra freeings lung and relieving asthma, inducing diuresis for removing edema;This nine Taste medicine can activating microcirculation and removing stasis medicinal, expelling wind and clearing away cold;Rhizoma Atractylodis Macrocephalae, Herba Cistanches, Radix Astragali invigorating qi for strengthening superficies, kidney-replenishing, diuretic and maintain drug;Cassia seed heat-clearing is bright Mesh;Cortex Phellodendri, rhizoma anemarrhenae, the coptis, rhizoma zingiberis, Rhizoma Atractylodis Macrocephalae heat-clearing and damp-drying drug, purging fire for removing toxin;Ramulus cinnamomi warming meridian, helps yang transforming qi;Anti- wind, relieving exterior syndrome is dispelled Wind;Rhizoma cyperi promoting qi circulation and removing obstruction in the collateral.This ten simply medicine share promoting blood circulation to remove blood stasis promoting the circulation of qi, and be avoided that too loss qi and blood;Hawthorn, Prunella vulgaris, Lotus nut, Divine Comedy, stir-baked FRUCTUS GARDENIAE, Radix Glycyrrhizae are to make medicine, calming the liver and benefiting the lungs, and dispelling wind-heat is invigorated the spleen and benefited qi, clearing away the heart fire and tranquillizing, coordinating the drug actions of a prescription.This hair Bright Chinese medicine composition and its preparation is effectively adjusted between each system of body using the mutual collaboration of pharmacological property between several kinds of Chinese medicinal materials Function balance, effective treatment hypertension, hyperlipidemia, high blood viscosity and both the above or three kinds of symptoms symptoms such as concurrently.
2, the present invention is dried the active constituent of Chinese medicine composition using Vacuum Freezing & Drying Technology, makes at low temperature Its water content is frozen into solid state, and then directly distillation is vapor under negative pressure, and is excluded from active constituent, thus Active constituent is set to obtain drying, this method is effectively prevented the various physical and chemical indexes of active constituent and biological nature does not change, again It is smaller to Chinese medicine biological tissue cell structure and features damage, so that it is rapidly entered dormant state, effectively maintains Chinese medicine thermal sensitivity, There is fine holding to act on some oxidizable substances, protects active drug composition, so that it will not be denaturalized and lose It is biological to lose its.Secondly freeze-drying drug object color does not send out change substantially, can quickly dissolve after taking, and restore original aqueous solution Physicochemical property and biological nature greatly improve pharmacodynamic feature.
3, Chinese medicine composition and its preparation provided by the invention are through clinical test, to treatment hypertension, hyperlipidemia, high blood viscosity And the cure rate of both the above or three kinds of symptoms symptoms such as concurrently, up to 80.41%, for total effective rate up to 98.97%, therapeutic effect is aobvious It writes, and the Liver and kidney function and hemopoietic system of patient is had no abnormal changes and adverse reaction, clinic are taken securely and reliably.
4, Traditional Chinese medicine composition formula of the invention is scientific and reasonable, and preparation method is simple, can be made into a variety of dosage forms, preparation cost It is low, body and the financial burden of patient can be mitigated significantly, wide application of the crowd has very big promotional value.
[specific embodiment]
In the following description, numerous specific details are set forth in order to facilitate a full understanding of the present invention.But the present invention can be with very much Implement different from other way described herein, those skilled in the art can do without violating the connotation of the present invention It is similar to improve, therefore the present invention is not limited to the specific embodiments disclosed below.
1 tablet of embodiment
Weigh pueraria lobata 0.1kg, Radix Astragali 1kg, hawthorn 0.5kg, cassia seed 1kg, Prunella vulgaris 1kg, stir-baked CORTEX EUCOMMIAE 1kg, herba taxilli 0.5kg, it radix scutellariae 0.3kg, coptis 1kg, lotus nut 0.1kg, radix aconiti lateralis preparata 0.1kg, Chinese ephedra 0.2kg, asarum 0.1kg, ramulus cinnamomi 1kg, does It is ginger 1kg, radix saposhnikoviae 0.5kg, scorpio 0.1kg, centipede 0.1kg, Herba Cistanches 1kg, Radix Salviae Miltiorrhizae 0.5kg, tuber fleeceflower stem 1kg, rhizoma atractylodis 1kg, big Yellow 0.1kg, rhizoma cyperi 0.5kg, Rhizoma Chuanxiong 1kg, Divine Comedy 1kg, stir-baked FRUCTUS GARDENIAE 0.5kg, Cortex Phellodendri 0.5kg, Radix Glycyrrhizae 0.1kg, rhizoma anemarrhenae 0.2kg, Rhizoma Atractylodis Macrocephalae 1kg, rhizoma alismatis 0.5kg;
Above-mentioned medicinal material is taken, is placed in pressure pan, and 3.3 times of water for being equivalent to medicinal material total weight is added, is forced into tank with steam Interior pressure is 0.6MPa, and controlling temperature of charge in tank is 128 DEG C, material in agitator tank, after steam pressure 4.5h, is naturally cooled to often Temperature takes the filtrate in tank, filtrate is placed in vacuum freeze drier and is freeze-dried, first the pre-freeze 1.4h at -11 DEG C, so The vacuum degree that vacuum freeze drier is arranged afterwards is 20Pa, and microwave heating makes filtrate temperature gradually rise to 0 DEG C from -11 DEG C, makes Free water sublimate in filtrate, sublimation time 2.2h, it is to be concentrated after filtrate when ice is not present, microwave heating, after making concentration Filtrate temperature rise rapidly and parsed, maximum temperature control keeps 0.9h at 16 DEG C, and in this temperature range, obtains 71 DEG C when relative density be 1.20 clear cream, obtain active constituent;Gained active constituent is taken, additive of tablet Icing Sugar, dextrin, shallow lake is added Powder, polyethylene glycol, talcum powder, cellulose derivative, routinely tablet is made in scheme.
2 capsule of embodiment
Pueraria lobata 0.3kg, Radix Astragali 1.4kg, hawthorn 1kg, cassia seed 1.1kg, Prunella vulgaris 1.2kg, stir-baked CORTEX EUCOMMIAE 1.1kg, mulberry is weighed to post Raw 1kg, radix scutellariae 0.4kg, coptis 1.2kg, lotus nut 0.2kg, radix aconiti lateralis preparata 0.2kg, Chinese ephedra 0.4kg, asarum 0.3kg, ramulus cinnamomi 1.4kg, rhizoma zingiberis 1.1kg, radix saposhnikoviae 0.6kg, scorpio 0.2kg, centipede 0.2kg, Herba Cistanches 1.4kg, Radix Salviae Miltiorrhizae 0.8kg, tuber fleeceflower stem 1.2kg, rhizoma atractylodis 1.1kg, rheum officinale 0.3kg, rhizoma cyperi 0.6kg, Rhizoma Chuanxiong 1.1kg, Divine Comedy 1.1kg, stir-baked FRUCTUS GARDENIAE 0.6kg, Cortex Phellodendri 0.7kg, Radix Glycyrrhizae 0.3kg, rhizoma anemarrhenae 0.4kg, Rhizoma Atractylodis Macrocephalae 1.4kg, rhizoma alismatis 0.7kg;
Above-mentioned medicinal material is taken, is placed in pressure pan, and 3.6 times of water for being equivalent to medicinal material total weight is added, is forced into tank with steam Interior pressure is 0.8MPa, and controlling temperature of charge in tank is 135 DEG C, material in agitator tank, after steam pressure 4h, is naturally cooled to often Temperature takes the filtrate in tank, filtrate is placed in vacuum freeze drier and is freeze-dried, first the pre-freeze 1.3h at -12 DEG C, so The vacuum degree that vacuum freeze drier is arranged afterwards is 35Pa, and microwave heating makes filtrate temperature gradually rise to 0 DEG C from -12 DEG C, makes Free water sublimate in filtrate, sublimation time 2h, it is to be concentrated after filtrate when ice is not present, microwave heating, after making concentration Filtrate temperature, which rises rapidly, to be parsed, and maximum temperature control keeps 0.8h at 17 DEG C, and in this temperature range, obtains 73 DEG C When relative density be 1.18 clear cream, obtain active constituent;Gained active constituent is taken, it is fine that capsule supplementary product starch, crystallite is added Element, polyethylene glycol, magnesium stearate are tieed up, routinely capsule is made in scheme.
3 oral solution of embodiment
Weigh pueraria lobata 0.5kg, Radix Astragali 1.5kg, hawthorn 1.5kg, cassia seed 1.2kg, Prunella vulgaris 1.5kg, stir-baked CORTEX EUCOMMIAE 1.2kg, mulberry Parasitic 1.5kg, radix scutellariae 0.6kg, coptis 1.2kg, lotus nut 0.3kg, radix aconiti lateralis preparata 0.3kg, Chinese ephedra 0.5kg, asarum 0.4kg, ramulus cinnamomi 1.5kg, rhizoma zingiberis 1.2kg, radix saposhnikoviae 0.6kg, scorpio 0.3kg, centipede 0.3kg, Herba Cistanches 1.5kg, Radix Salviae Miltiorrhizae 1kg, tuber fleeceflower stem 1.5kg, rhizoma atractylodis 1.2kg, rheum officinale 0.5kg, rhizoma cyperi 0.6kg, Rhizoma Chuanxiong 1.2kg, Divine Comedy 1.2kg, stir-baked FRUCTUS GARDENIAE 0.6kg, Cortex Phellodendri 0.8kg, Radix Glycyrrhizae 0.5kg, rhizoma anemarrhenae 0.5kg, Rhizoma Atractylodis Macrocephalae 1.5kg, rhizoma alismatis 1kg;
Above-mentioned medicinal material is taken, is placed in pressure pan, and 4 times of water for being equivalent to medicinal material total weight is added, is forced into tank with steam Pressure is 1.0MPa, and controlling temperature of charge in tank is 150 DEG C, material in agitator tank, after steam pressure 3.5h, is naturally cooled to often Temperature takes the filtrate in tank, filtrate is placed in vacuum freeze drier and is freeze-dried, first the pre-freeze 1.2h at -13 DEG C, so The vacuum degree that vacuum freeze drier is arranged afterwards is 50Pa, and microwave heating makes filtrate temperature gradually rise to 0 DEG C from -13 DEG C, makes Free water sublimate in filtrate, sublimation time 1.8h, it is to be concentrated after filtrate when ice is not present, microwave heating, after making concentration Filtrate temperature rise rapidly and parsed, maximum temperature control keeps 0.7h at 18 DEG C, and in this temperature range, obtains 75 DEG C when relative density be 1.12 clear cream, obtain active constituent;Gained active constituent is taken, oral solution auxiliary material sorbic acid, first is added Ester, water stir evenly, and oral solution is made.
4 syrup of embodiment
Weigh pueraria lobata 2kg, Radix Astragali 2kg, hawthorn 2.5kg, cassia seed 1.8kg, Prunella vulgaris 2.5kg, stir-baked CORTEX EUCOMMIAE 1.8kg, herba taxilli 2.5kg, radix scutellariae 1.5kg, coptis 1.8kg, lotus nut 0.7kg, radix aconiti lateralis preparata 0.7kg, Chinese ephedra 1kg, asarum 0.8kg, ramulus cinnamomi 2.5kg, It is rhizoma zingiberis 1.8kg, radix saposhnikoviae 0.8kg, scorpio 0.7kg, centipede 0.7kg, Herba Cistanches 2.5kg, Radix Salviae Miltiorrhizae 1.5kg, tuber fleeceflower stem 2.5kg, grey Art 1.8kg, rheum officinale 1kg, rhizoma cyperi 0.8kg, Rhizoma Chuanxiong 1.4kg, Divine Comedy 1.8kg, stir-baked FRUCTUS GARDENIAE 0.8kg, Cortex Phellodendri 1.2kg, Radix Glycyrrhizae 1.5kg, rhizoma anemarrhenae 1kg, Rhizoma Atractylodis Macrocephalae 2.5kg, rhizoma alismatis 1.5kg;
Above-mentioned medicinal material is taken, is placed in pressure pan, and 4.3 times of water for being equivalent to medicinal material total weight is added, is forced into tank with steam Interior pressure is 1.2MPa, and controlling temperature of charge in tank is 160 DEG C, material in agitator tank, after steam pressure 3h, is naturally cooled to often Temperature takes the filtrate in tank, filtrate is placed in vacuum freeze drier and is freeze-dried, first the pre-freeze 1.1h at -14 DEG C, so The vacuum degree that vacuum freeze drier is arranged afterwards is 68Pa, and microwave heating makes filtrate temperature gradually rise to 0 DEG C from -14 DEG C, makes Free water sublimate in filtrate, sublimation time 1.6h, it is to be concentrated after filtrate when ice is not present, microwave heating, after making concentration Filtrate temperature rise rapidly and parsed, maximum temperature control keeps 0.6h at 17 DEG C, and in this temperature range, obtains 77 DEG C when relative density be 1.10 clear cream, obtain active constituent;Gained active constituent is taken, syrup auxiliary material sucrose, sorb is added Acid and water stir evenly, and syrup is made.
5 mixture of embodiment
Weigh pueraria lobata 2.5kg, Radix Astragali 2.4kg, hawthorn 2.8kg, cassia seed 1.9kg, Prunella vulgaris 2.7kg, stir-baked CORTEX EUCOMMIAE 1.9kg, mulberry Parasitic 2.6kg, radix scutellariae 1.8kg, coptis 1.8kg, lotus nut 0.8kg, radix aconiti lateralis preparata 0.8kg, Chinese ephedra 1.2kg, asarum 0.9kg, ramulus cinnamomi 2.7kg, rhizoma zingiberis 1.8kg, radix saposhnikoviae 0.9kg, scorpio 0.8kg, centipede 0.8kg, Herba Cistanches 2.6kg, Radix Salviae Miltiorrhizae 1.7kg, tuber fleeceflower stem 2.7kg, rhizoma atractylodis 1.9kg, rheum officinale 1.2kg, rhizoma cyperi 0.9kg, Rhizoma Chuanxiong 1.4kg, Divine Comedy 1.8kg, stir-baked FRUCTUS GARDENIAE 0.9kg, Cortex Phellodendri 1.4kg, Radix Glycyrrhizae 1.8kg, rhizoma anemarrhenae 1.2kg, Rhizoma Atractylodis Macrocephalae 2.7kg, rhizoma alismatis 1.6kg;
Above-mentioned medicinal material is taken, is placed in pressure pan, and 4.6 times of water for being equivalent to medicinal material total weight is added, is forced into tank with steam Interior pressure is 1.4MPa, and controlling temperature of charge in tank is 170 DEG C, material in agitator tank, after steam pressure 2.2h, is naturally cooled to often Temperature takes the filtrate in tank, filtrate is placed in vacuum freeze drier and is freeze-dried, first the pre-freeze 1h at -15 DEG C, then The vacuum degree that vacuum freeze drier is arranged is 88Pa, and microwave heating makes filtrate temperature gradually rise to 0 DEG C from -15 DEG C, makes to filter Free water sublimate in liquid, sublimation time 1.5h, it is to be concentrated after filtrate when ice is not present, microwave heating, after making concentration Filtrate temperature, which rises rapidly, to be parsed, and maximum temperature control keeps 0.5h at 15 DEG C, and in this temperature range, obtains 78 DEG C When relative density be 1.08 clear cream, obtain active constituent;Gained active constituent is taken, mixture auxiliary material monosaccharide, benzoic acid is added, stirs It mixes uniformly, mixture is made.
6 granule of embodiment
Weigh pueraria lobata 3kg, Radix Astragali 3kg, hawthorn 3kg, cassia seed 2kg, Prunella vulgaris 3kg, stir-baked CORTEX EUCOMMIAE 2kg, herba taxilli 3kg, radix scutellariae 2kg, coptis 2kg, lotus nut 1kg, radix aconiti lateralis preparata 1kg, Chinese ephedra 1.5kg, asarum 1kg, ramulus cinnamomi 3kg, rhizoma zingiberis 2kg, radix saposhnikoviae 1kg, scorpio 1kg, centipede 1kg, Herba Cistanches 3kg, Radix Salviae Miltiorrhizae 1.5kg, tuber fleeceflower stem 3kg, rhizoma atractylodis 2kg, rheum officinale 1.5kg, rhizoma cyperi 1kg, Rhizoma Chuanxiong 1.5kg, Divine Comedy 2kg, stir-baked FRUCTUS GARDENIAE 1kg, Cortex Phellodendri 1.5kg, Radix Glycyrrhizae 2kg, rhizoma anemarrhenae 1.3kg, Rhizoma Atractylodis Macrocephalae 3kg, rhizoma alismatis 2kg;
Above-mentioned medicinal material is taken, is placed in pressure pan, and 5 times of water for being equivalent to medicinal material total weight is added, is forced into tank with steam Pressure is 1.5MPa, and controlling temperature of charge in tank is 180 DEG C, material in agitator tank, after steam pressure 1.5h, is naturally cooled to often Temperature takes the filtrate in tank, filtrate is placed in vacuum freeze drier and is freeze-dried, first the pre-freeze 1h at -15 DEG C, then The vacuum degree that vacuum freeze drier is arranged is 100Pa, and microwave heating makes filtrate temperature gradually rise to 0 DEG C from -15 DEG C, makes Free water sublimate in filtrate, sublimation time 1.5h, it is to be concentrated after filtrate when ice is not present, microwave heating, after making concentration Filtrate temperature rise rapidly and parsed, maximum temperature control keeps 0.5h at 17 DEG C, and in this temperature range, obtains 80 DEG C when relative density be 1.05 clear cream, obtain active constituent;Gained active constituent is taken, auxiliary material lactose, gelatin is added, is crosslinked and gathers Ketone, starch, microcrystalline cellulose are tieed up, granule is made in granulation, dry, whole grain.
7 pill of embodiment
Weigh pueraria lobata 1.5kg, Radix Astragali 1.8kg, hawthorn 2kg, cassia seed 1.5kg, Prunella vulgaris 2kg, stir-baked CORTEX EUCOMMIAE 1.5kg, herba taxilli 2kg, radix scutellariae 1kg, coptis 1.5kg, lotus nut 0.5kg, radix aconiti lateralis preparata 0.5kg, Chinese ephedra 0.8kg, asarum 0.6kg, ramulus cinnamomi 2kg, rhizoma zingiberis 1.5kg, radix saposhnikoviae 0.7kg, scorpio 0.5kg, centipede 0.5kg, Herba Cistanches 2kg, Radix Salviae Miltiorrhizae 1.2kg, tuber fleeceflower stem 2kg, rhizoma atractylodis 1.5kg, Rheum officinale 0.7kg, rhizoma cyperi 0.7kg, Rhizoma Chuanxiong 1.2kg, Divine Comedy 1.6kg, stir-baked FRUCTUS GARDENIAE 0.7kg, Cortex Phellodendri 1kg, Radix Glycyrrhizae 1kg, rhizoma anemarrhenae 0.8kg, Rhizoma Atractylodis Macrocephalae 2kg, rhizoma alismatis 1.2kg;
Above-mentioned medicinal material is taken, is placed in pressure pan, and 3 times of water for being equivalent to medicinal material total weight is added, is forced into tank with steam Pressure is 0.4MPa, and controlling temperature of charge in tank is 120 DEG C, material in agitator tank, after steam pressure 5h, naturally cools to room temperature, The filtrate in tank is taken, filtrate is placed in vacuum freeze drier and is freeze-dried, first the pre-freeze 1.5h at -10 DEG C, then The vacuum degree that vacuum freeze drier is arranged is 5Pa, and microwave heating makes filtrate temperature gradually rise to 0 DEG C from -10 DEG C, makes to filter Free water sublimate in liquid, sublimation time 2.5h, it is to be concentrated after filtrate when ice is not present, microwave heating, after making concentration Filtrate temperature, which rises rapidly, to be parsed, and maximum temperature control keeps 1h at 15 DEG C, and in this temperature range, when obtaining 70 DEG C The clear cream that relative density is 1.25, obtains active constituent;Gained active constituent is taken, edible gelatin, maltose, honey, jade is added Concentration pill is made to get pill of the present invention in rice starch.
Clinical test is summarized
1, basic document
97 patients are selected, male 50, female 47, the age 32-95 years old, the course of disease was most 3 months short, and longest 22 years.It is wherein simple high Blood pressure person 18, hypertension and hyperlipidemia person 15, the three disease persons of having concurrently 23.
2, diagnostic criteria
Hypertension: clinical diagnosis meets standard as defined in the World Health Organization (WTO), and basic blood pressure is greater than or equal to before treating 160/95mmHg。
Hyperlipidemia, high blood viscosity: referring to " Chinese medicine Clinical Researches of New Drugs guideline " (trial version in 2002) and " Chinese Adult The standard of dyslipidemia guideline of prevention and treatment (2007 editions) is evaluated.
3, curative effect judging standard
Clinical cure: laboratory Index for examination restores to normal, and symptom integral reduces 80% or more, and corresponding Scale assessment is equal Restore to normal 80% or more.
Effective: laboratory Index for examination is obviously improved, and symptom integral reduces 60-79%, and corresponding Scale assessment restores To normal 60-79%.
Effective: laboratory Index for examination improves, and symptom integral reduces 40-59%, and corresponding Scale assessment restores to just Normal 40-59%
Invalid: for laboratory Index for examination without improving or deteriorating, symptom integral reduces 39% hereinafter, corresponding Scale assessment is extensive Again to normal 39% or less.
4, treatment method
It is given and is treated using the pill of the embodiment of the present invention 7,3 times a day, each 5g, 30 days for a course for the treatment of.
5, result
By the treatment of the 3-7 course for the treatment of, clinical efficacy is shown in Table 1.
1 therapeutic effect of table
Healing/example Effective/example Effectively In vain/example Cure rate/% Total effective rate/%
78 12 6 1 80.41 98.97
As it can be seen from table 1 the treatment by the 3-7 course for the treatment of, Chinese medicine composition of the invention and preparation are for hypertension, high blood The illnesss such as rouge, high blood viscosity have apparent therapeutic effect, and when treatment has no toxic side effect, and medication is convenient, and cure rate is up to 80.41%, always Effective percentage up to 98.97%, has no abnormal changes the Liver and kidney function and hemopoietic system of patient and adverse reaction, sick after drug withdrawal " rebounding " do not occur in feelings, and clinic is taken securely and reliably.Since conditions of patients weight and course of disease length are different, to drug susceptibility There is also individual difference, most of patients can take effect in 2 courses for the treatment of, and clinical cure in the 3-5 course for the treatment of, few patients then need 6- 7 courses for the treatment of can be only achieved clinical cure.
Typical case
Case 1: XX, male, 46 years old, Guangxi Mo Fu the wine industry Group Co., Ltd employee.
Main suit: patient suffers from hypertension 7 years, often takes indapamide tablets and Nifedipine Tablets Western medicine carrys out blood pressure lowering, but Systolic pressure fluctuates between 155-170mmHg for a long time, content of triglyceride 4.8mmol/L, and total cholesterol level is 13.2mmol/L, Hyperlipidemia, blood viscosity are exceeded.Patient feels head distending pain, hypomnesia, and numb limb is occasionally lost It sleeps, the symptoms such as frequent urination at night.First visit on March 2 in 2019, blood pressure 170/110mmHg, 115 beats/min of heart rate, constitution is fat, the fat tongue fur of tongue Huang, phlegm wet weight, heart kidney is non-intersecting, and gallbladder channel is not smooth.Take the tablet of the present embodiment 17 days, on March 9 two examined, blood pressure 155/ 100mmHg, 105 beats/min of heart rate, in blood lipid content of triglyceride be 3.9mmol/L, total cholesterol level 11.5mmol/L, Blood lipid is reduced, blood viscosity decline.Continue to take 7 days, three examine detection patients' blood 138/80mmHg, heart rate 83 times/ Point, blood lipid and blood viscosity continue to decline, then proceed to take 21 days, measuring blood pressure 130/72mmHg, 71 beats/min of heart rate, and blood The indexs such as rouge and blood viscosity restore normal.Further consultation after being discontinued 1 month, the blood pressure of patient, blood lipid from three examine after substantially without change Change, blood pressure, blood lipid, blood viscosity, heart rate restore normal.
Case 2: beam XX, male, 40 years old, Chinese transportation built joint-stock company employee.
Main suit: patient suffers from hypertension with coronary heart disease 5 years, and patient takes telmisartan capsules Western medicine often to be depressured, but Systolic pressure fluctuates between 150-165mmHg for a long time, and it is bored alliteration often occur, extremity numbness, hypomnesia, frequent urination at night, nervous Shortness of breath occasionally has insomnia.First visit on January 3 in 2019, blood pressure 185/115mmHg, 125 beats/min of heart rate, constitution is fat, and the fat tongue fur of tongue is thick Greasy, deeptensepulse void is sliding.Take the granule of the embodiment of the present invention 67 days, on January 11 two examined blood pressure 160/100mmHg, heart rate 105 Beat/min, continue after taking 7 days two and examine, blood pressure 135/78mmHg, is further continued for taking 7 days, blood pressure 126/ by 76 beats/min of heart rate 72mmHg, is hereafter discontinued by 70 beats/min of heart rate, returns and examines after 3 months, the blood pressure of patient from three examine after substantially unchanged, blood pressure, the heart Rate restores normal.
Case 3: river XX, male, 92 years old, the father of the safety endowment insurance limited liability company Guangxi branch company employee river X tinkling of pieces of jade.
Main suit: patient has hypertension 30 years, often takes the Western medicine such as nifedipine and carrys out blood pressure lowering, but systolic pressure exists for a long time 170mmHg or so fluctuation, often has a headache, eye-blurred, failure of memory, extremity numbness, the symptoms such as frequent urination at night.2018 September first visit on the 23rd, blood pressure 180/110mmHg, 130 beats/min of heart rate, constitution is fat, the fat whitish tongue of tongue, deficient and rapid pulse.Due to patient year Year high, endocrine disturbance, three is burnt not smooth, takes the oral solution of the embodiment of the present invention 3, light diaphoretic prescription amount is taken.It examines within September 30 days two Blood pressure 170/105mmHg, continues to take 7 days, three examine blood pressure 145/85mmHg, and 85 beats/min of heart rate, three examine by 115 beats/min of heart rate After continue to take 7 days, four methods of diagnosis blood pressure 135/76mmHg, 75 beats/min of heart rate, be discontinued.It returns and examines after 3 months, patients' blood, heart rate are extensive It is multiple normal.

Claims (5)

1. a kind of Chinese medicine composition for treating hypertension, hyperlipidemia, high blood viscosity, which is characterized in that by the raw material of following parts by weight It is prepared: 0.1-3 parts of pueraria lobata, 1-3 parts of Radix Astragali, 0.5-3 parts of hawthorn, 1-2 parts of cassia seed, 1-3 parts of Prunella vulgaris, stir-baked CORTEX EUCOMMIAE 1-2 Part, 0.5-3 parts of herba taxilli, 0.3-2 parts of radix scutellariae, 1-2 parts of the coptis, 0.1-1 parts of lotus nut, 0.1-1 parts of radix aconiti lateralis preparata, Chinese ephedra 0.2-1.5 Part, 0.1-1 parts of asarum, 1-3 parts of ramulus cinnamomi, 1-2 parts of rhizoma zingiberis, 0.5-1 parts of radix saposhnikoviae, 0.1-1 parts of scorpio, 0.1-1 parts of centipede, Herba Cistanches 1-3 parts, 0.5-2 parts of Radix Salviae Miltiorrhizae, 1-3 parts of tuber fleeceflower stem, 1-2 parts of rhizoma atractylodis, 0.1-1.5 parts of rheum officinale, 0.5-1 parts of rhizoma cyperi, Rhizoma Chuanxiong 1-1.5 Part, 1-2 parts of Divine Comedy, 0.5-1 parts of stir-baked FRUCTUS GARDENIAE, 0.5-1.5 parts of Cortex Phellodendri, 0.1-2 parts of Radix Glycyrrhizae, 0.2-1.3 parts of rhizoma anemarrhenae, 1-3 parts of Rhizoma Atractylodis Macrocephalae, 0.5-2 parts of rhizoma alismatis.
2. the Chinese medicine composition for the treatment of hypertension according to claim 1, hyperlipidemia, high blood viscosity, which is characterized in that by such as The raw material of lower parts by weight is prepared: 0.5-2 parts of pueraria lobata, 1.5-2 parts of Radix Astragali, 1.5-2.5 parts of hawthorn, 1.2-1.8 parts of cassia seed, 1.5-2.5 parts of Prunella vulgaris, 1.2-1.8 parts of stir-baked CORTEX EUCOMMIAE, 1.5-2.5 parts of herba taxilli, 0.6-1.5 parts of radix scutellariae, 1.2-1.8 parts of the coptis, 0.3-0.7 parts of lotus nut, 0.3-0.7 parts of radix aconiti lateralis preparata, 0.5-1 parts of Chinese ephedra, 0.4-0.8 parts of asarum, 1.5-2.5 parts of ramulus cinnamomi, rhizoma zingiberis 1.2-1.8 parts, 0.6-0.8 parts of radix saposhnikoviae, 0.3-0.7 parts of scorpio, 0.3-0.7 parts of centipede, 1.5-2.5 parts of Herba Cistanches, Radix Salviae Miltiorrhizae 1-1.5 Part, 1.5-2.5 parts of tuber fleeceflower stem, 1.2-1.8 parts of rhizoma atractylodis, 0.5-1 parts of rheum officinale, 0.6-0.8 parts of rhizoma cyperi, 1.2-1.4 parts of Rhizoma Chuanxiong, Divine Comedy 1.2-1.8 parts, 0.6-0.8 parts of stir-baked FRUCTUS GARDENIAE, 0.8-1.2 parts of Cortex Phellodendri, 0.5-1.5 parts of Radix Glycyrrhizae, 0.5-1 parts of rhizoma anemarrhenae, Rhizoma Atractylodis Macrocephalae 1.5-2.5 Part, 1-1.5 parts of rhizoma alismatis.
3. the Chinese medicine composition for the treatment of hypertension according to claim 1, hyperlipidemia, high blood viscosity, which is characterized in that by such as The raw material of lower parts by weight is prepared: 1.5 parts of pueraria lobata, 2 parts of hawthorn, 1.5 parts of cassia seed, 2 parts of Prunella vulgaris, fries Du at 1.8 parts of Radix Astragali Secondary 1.5 parts, 2 parts of herba taxilli, 1 part of radix scutellariae, 1.5 parts of the coptis, 0.5 part of lotus nut, 0.5 part of radix aconiti lateralis preparata, 0.8 part of Chinese ephedra, asarum 0.6 Part, 2 parts of ramulus cinnamomi, 1.5 parts of rhizoma zingiberis, windproof 0.7 part, 0.5 part of scorpio, 0.5 part of centipede, 2 parts of Herba Cistanches, 1.2 parts of Radix Salviae Miltiorrhizae, tuber fleeceflower stem 2 parts, it is 1.5 parts of rhizoma atractylodis, 0.7 part of rheum officinale, 0.7 part of rhizoma cyperi, 1.2 parts of Rhizoma Chuanxiong, 1.6 parts of Divine Comedy, 0.7 part of stir-baked FRUCTUS GARDENIAE, 1 part of Cortex Phellodendri, sweet Careless 1 part, 0.8 part of rhizoma anemarrhenae, 2 parts of Rhizoma Atractylodis Macrocephalae, 1.2 parts of rhizoma alismatis.
4. the Chinese medicine composition for the treatment of hypertension according to claim 1-3, hyperlipidemia, high blood viscosity, feature It is, its active constituent is made of being prepared by the following method:
Whole medicinal materials are taken, are placed in pressure pan, and 3-5 times of water for being equivalent to medicinal material total weight is added, are forced into tank with steam Interior pressure is 0.4-1.5MPa, and controlling temperature of charge in tank is 120-180 DEG C, material in agitator tank, after steam pressure 1.5-5h, from It is so cooled to room temperature, takes the filtrate in tank, filtrate is placed in vacuum freeze drier and is freeze-dried, obtain 70-78 DEG C When relative density be 1.05-1.25 clear cream, obtain active constituent.
5. a kind of Chinese materia medica preparation for treating hypertension, hyperlipidemia, high blood viscosity, which is characterized in that by any one of claim 1-3 institute The treatment hypertension stated, hyperlipidemia, high blood viscosity Chinese medicine composition and pharmaceutically acceptable carrier combination be prepared.
CN201910632953.2A 2019-07-15 2019-07-15 A kind of Chinese medicine composition and preparation for treating hypertension, hyperlipidemia, high blood viscosity Pending CN110193076A (en)

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