CN104666663A

CN104666663A - Medicine for treating damp toxin immersed type edema and preparation method of medicine

Info

Publication number: CN104666663A
Application number: CN201510138466.2A
Authority: CN
Inventors: 李佃场
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-03-27
Filing date: 2015-03-27
Publication date: 2015-06-03

Abstract

The invention discloses a medicine for treating damp toxin immersed type edema and a preparation method of the medicine. The medicine comprises the following bulk drugs: soft water coptis, platycodon grandiflorum, fructus arctii, stellaria neglecta, blacken saussurea herb, herba schizonepetae, drymotaenium miyoshianum, rhizoma atractylodis, daimyo oak leaves, periostracum cicada, radix saposhnikoviae, paleyellow elsholtzia herb, radix sophorae flavescentis, ligularia lapathifolia, radix puerariae, fleshy spurge pistil and stamen, gardenia, patrinia heterophylla, honeysuckle, periploca forrestii roots, dandelion, phellodendron amurense, swertia erythrosticta maxim, cortex dictamni, fructus forsythiae, cirsium esculentum, berberidis, andrographis paniculata, lobelia chinensis, physalis angulata, poria cocos, rhizoma alismatis, rubus rufo-lanatus, polyporus, cortex periplocae, ricepaperplant pith, fructus kochiae and mountain magnolia flowers. The medicine has the beneficial effects that the medicine has the efficacies of clearing away heat, drying dampness and inducing diuresis to reduce edema, mainly treats damp toxin immersed type edema, and has the characteristics that the medicine takes effect rapidly, is high in efficiency, definite in curative effect, high in safety, and short in treatment course, and has no toxic or side effect; the drug efficacy reaches a focus directly; the drug resistance does not generate easily; the preparation process is simple and convenient; the cost is low; and the possibility of relapse after cure is low.

Description

A kind ofly treat medicine of noxious dampness contamination type edema and preparation method thereof

Technical field

The present invention relates to technical field of pharmaceuticals, particularly a kind ofly treat medicine of noxious dampness contamination type edema and preparation method thereof.

Background technology

Edema refers in EV interstice have too much body fluid accumulation, is one of clinical common sympton.Edema is the one performance of whole body gasification function obstacle, closely related with lung, spleen, kidney, three burnt each internal organs.Be divided into YANG edema, YIN edema two class according to Symptoms difference, be common in the diseases such as nephritis, pulmonary heart disease, liver cirrhosis, malnutrition and endocrine disturbance.

Edema shows as: time position (on front side of shank) that finger presses subcutaneous tissue is few, have obvious depression.Edema is a common pathological process, and its body fluid gathered is from blood plasma, and ratio and the blood plasma of its sodium and water are roughly the same.Traditionally, too much body fluid is gathered in body cavity and is called hydrops or hydrops, as hydrothorax, hydroabdomen, hydropericardium etc.Edema is originally many from eyelid, continues, and prolongs and women's head-ornaments, extremity, the abdomen back of the body, notably swollen all over whole body, the edema also had first from lower limb foot shin, then and in whole body.The lighter is eyelid or sufficient shin edema only, and severe one whole body is all swollen, and swollen place skin stretches tight anxious light, by depression namely rise, or cutis laxa, the depression of pressing not easily is recovered, very then press as mud.As swollen gesture is serious, can see abdominal distension with ascites pleural fluid, chest distress and palpitation symptoms, asthma can not be put down sleeping, and lip is black, supraclavicular fossa, umbilical hernia, back of the body equality disease.

Chinese medicine is thought, edema refers to because of being invaded by exogenous pathogen, drinking and eating irregularly, or overstrain etc., make the logical tune of impairment of dispersing and descending function of the lung, dysfunction of the spleen in transportation, kidney loses folding, and functioning of bladder is not normal, cause water retention in body, spread unchecked skin, with women's head-ornaments, eyelid, extremity, the abdomen back of the body, even anasarca is a class disease of Clinical symptoms.Primary disease is called in "Nei Jing" " water ", and is divided into edema due to wind pathogen, stony edema, retention of excessive fluid according to different symptoms." Ling Shu Miraculous Pivot or Divine Axis, watery distension " section has done detailed description to its symptom, as " water has begun also, slightly swelling of the eyelids, and as the shape newly crouched, its notable and rashing pulsation of common carotid artery, time is coughed, cold over the region between the genitalia and thigh, puffiness of the legs, and abdomen is large, and its water becomes.With hands by its abdomen, rise, ascites as if water being contained within the abdomen conveniently, this its time also." to its pathogenic factor, " a Plain Questions hydro-thermal cave opinion section " is pointed out: " thus the fundamental cause of water disease being in the kidney, the incidental cause of water disease being in the lung." " Plain Questions the most pure virginity will discuss a section greatly " point out again: " all damp-edema are full, all belong to spleen." visible in the "Nei Jing" epoch, clearer and more definite understanding be there has been to edema disease." Medical Treasures of the Golden Chamber " claims primary disease to be " aqueous vapor ", is divided into edema due to wind pathogen, the severe edema due to hypofunction of the spleen, the anasarca with shortness of breath, stony edema, yellowish perspiration five class by the cause of disease, disease.Edema with the heart involved, edema caused by the lung disorder, edema caused by disorder of the liver, edema caused by the spleen disease, kidney water is divided into again according to the five internal organs syndrome.Just edema is divided into YIN edema and the large class of YANG edema two to Yuan Dynasty's " danxi's experiential therapy edema ", points out: " if general edema, excessive thirst, hot urination, stool closes, and this belongs to YANG edema; If " general edema, not excessive thirst, large loose stool, oliguria, not puckery red, this belongs to YIN edema ".This sorting technique is still significant to instructing clinical syndrome differentiation so far.Ming Dynasty's " Elementary Medicine miscellaneous diseases classification edema " proposes desolation and can cause edema, and describe the phenomenon of " abscess is applied ointment; swell more afterwards ", the Qing Dynasty " Zhengzi Huibu edema " the induction and conclusion method for the treatment of of former worthies about edema, think swollen rule for the treatment of of harnessing the river, and " spleen invigorating in should adjusting; sthenic splenoqi; self energy lifting runs, then water is wet from removing, and this controls it also." list again six methods of dividing and ruling of edema simultaneously: control forked rubbing, control point antiperspirant ooze, damp and hot should clearly, cold-damp should warm, the deficiency of YIN should be mended, the domination of pathogen ought be attacked.Be respectively the etiology that improves edema and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs has made respective contribution.

The etiology and pathogenesis of edema: the operation of human liquid, depends on the promotion of gas, and the liter namely depending on temper is transferred, and the Xuan Jiangtong of lung qi adjusts, the promotion of the motive, kidney qi evaporate folding.These functions are normal, then three burnt performances certainly show disrespect on effect, and functioning of bladder passes unimpeded, normal urination, can maintain the metabolism of normal water liquid.Otherwise if because of the damp and hot heresy of affection of exogenous wind-cold, the wet dipping of water, sore is contaminated, and improper diet and overtiredness, weakness due to chronic disease etc. cause above-mentioned visceral dysfunction, and three Jiao certainly show disrespect on mistake department, and functioning of bladder is unfavorable, and water retention in body, spreads unchecked skin, can send out as edema.Therefore distinguish that its cause of disease is divided into: attack type outside ailment said due to cold or exposure, noxious dampness contamination type, water wets proofing type, damp and hot interior Sheng type, improper diet and overtiredness type, asthenia of renal qi type; Wherein, noxious dampness contamination type: carbuncle and ulcer sore is born in skin, fail removing summer-heat and in return lung spleen, damage of the spleen can not rise Tianjin, and lung wound is lost a surname Yu and fallen, so that in water retention body, spreads unchecked skin, sends out as edema." Prescriptions for Succouring the Sick edema " is called: " have again young, the raw skin ulcer of heat in blood, becomes generalized edema with distention of the chest and abdomen, excessive thirst, oliguria, and this is that heat is swollen.”

The patient of current treatment edema should for etiological treatment, and the edema of lower limbs caused for conscience kidney diaseases can give diuretic, can mitigation symptoms.Hypothyroidism person can take thyroxin tablet treatment.Deep vein thrombosis of lower extremity sexually transmitted disease (STD) is become and can take operation.In order to prevention of deep vein thrombosis is formed, anticoagulation treatment should be given.Modern medical therapy noxious dampness contamination type edema drugs kind is less, and the untoward reaction caused after medication is more, the course for the treatment of is longer, do not reach desirable clinical effectiveness.Therefore, a kind of untoward reaction of clinical needs is less, toxic and side effects is low, the good drug treatment edema of curative effect, meet clinical needs.

Summary of the invention

Technical problem to be solved by this invention is, a kind of medicine for the treatment of noxious dampness contamination type edema of effect with heat clearing and damp drying, inducing diuresis to remove edema is provided, mouthfeel is suitable for, patient is easy to accept, and have rapid-action, efficiency is high, determined curative effect, safety are high, have no side effect, treat short treating period, drug effect goes directly focus, not easily produces drug resistance, and processing technology is easy, with low cost, the not easily feature such as recurrence more.

For solving the problems of the technologies described above, the invention provides a kind of medicine for the treatment of noxious dampness contamination type edema, wherein, the various raw medicinal material of described medicine is: Herba Thalictri Ramosi, Radix Platycodonis, Fructus Arctii, match Herba stellariae mediae, Herba saussureae nigrescentis, Herba Schizonepetae, Drymotaenium miyoshianum (Mak.) Mak., Rhizoma Atractylodis, Folium Querci dentatae, Periostracum Cicadae, Radix Saposhnikoviae, Herba elsholtziae luteolae, Radix Sophorae Flavescentis, Folium rumicis acetosae Farfugium kaemferi, Radix Puerariae, Stamen Euphorbiae Antiquori, Fructus Gardeniae, Radix Patriniae heterophyllae, Flos Lonicerae, Radix Rubi parvifolii, Herba Taraxaci, Cortex Phellodendri, Herba Swertiae erythrostictae, Cortex Dictamni, Fructus Forsythiae, Herba cirsii esculenti, Radix Berberidis, Herba Andrographis, Herba Lobeliae Chinensis, Herba Physalis pubescentis, Poria, Rhizoma Alismatis, Rubus rufolanatus H. T. Chang, Polyporus, Cortex Periplocae, Medulla Tetrapanacis, the Fructus Kochiae and Flos Micheliae Yunnanensis.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Thalictri Ramosi 15-35 part, Radix Platycodonis 10-30 part, Fructus Arctii 15-35 part, match Herba stellariae mediae 10-35 part, Herba saussureae nigrescentis 10-30 part, Herba Schizonepetae 17-35 part, Drymotaenium miyoshianum (Mak.) Mak. 10-30 part, Rhizoma Atractylodis 15-35 part, Folium Querci dentatae 10-25 part, Periostracum Cicadae 15-35 part, Radix Saposhnikoviae 19-35 part, Herba elsholtziae luteolae 17-35 part, Radix Sophorae Flavescentis 10-30 part, Folium rumicis acetosae Farfugium kaemferi 15-35 part, Radix Puerariae 15-35 part, Stamen Euphorbiae Antiquori 17-35 part, Fructus Gardeniae 10-30 part, Radix Patriniae heterophyllae 15-35 part, Flos Lonicerae 10-30 part, Radix Rubi parvifolii 17-35 part, Herba Taraxaci 15-35 part, Cortex Phellodendri 10-30 part, Herba Swertiae erythrostictae 15-35 part, Cortex Dictamni 17-35 part, Fructus Forsythiae 10-30 part, Herba cirsii esculenti 15-35 part, Radix Berberidis 10-30 part, Herba Andrographis 15-30 part, Herba Lobeliae Chinensis 17-30 part, Herba Physalis pubescentis 18-35 part, Poria 10-30 part, Rhizoma Alismatis 15-35 part, Rubus rufolanatus H. T. Chang 18-30 part, Polyporus 10-30 part, Cortex Periplocae 15-35 part, Medulla Tetrapanacis 10-30 part, Fructus Kochiae 15-35 part and Flos Micheliae Yunnanensis 15-30 part.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Thalictri Ramosi 17-30 part, Radix Platycodonis 15-30 part, Fructus Arctii 17-35 part, match Herba stellariae mediae 10-30 part, Herba saussureae nigrescentis 15-30 part, Herba Schizonepetae 17-30 part, Drymotaenium miyoshianum (Mak.) Mak. 15-30 part, Rhizoma Atractylodis 15-30 part, Folium Querci dentatae 16-25 part, Periostracum Cicadae 17-30 part, Radix Saposhnikoviae 20-35 part, Herba elsholtziae luteolae 17-30 part, Radix Sophorae Flavescentis 15-30 part, Folium rumicis acetosae Farfugium kaemferi 15-30 part, Radix Puerariae 17-35 part, Stamen Euphorbiae Antiquori 18-30 part, Fructus Gardeniae 15-30 part, Radix Patriniae heterophyllae 15-30 part, Flos Lonicerae 15-30 part, Radix Rubi parvifolii 18-35 part, Herba Taraxaci 15-30 part, Cortex Phellodendri 16-30 part, Herba Swertiae erythrostictae 18-30 part, Cortex Dictamni 19-35 part, Fructus Forsythiae 15-30 part, Herba cirsii esculenti 17-30 part, Radix Berberidis 15-30 part, Herba Andrographis 15-25 part, Herba Lobeliae Chinensis 17-25 part, Herba Physalis pubescentis 18-30 part, Poria 10-25 part, Rhizoma Alismatis 15-30 part, Rubus rufolanatus H. T. Chang 22-30 part, Polyporus 15-30 part, Cortex Periplocae 15-30 part, Medulla Tetrapanacis 15-30 part, Fructus Kochiae 17-35 part and Flos Micheliae Yunnanensis 18-25 part.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Thalictri Ramosi 20 parts, Radix Platycodonis 18 parts, Fructus Arctii 22 parts, match Herba stellariae mediae 17 parts, Herba saussureae nigrescentis 25 parts, Herba Schizonepetae 20 parts, Drymotaenium miyoshianum (Mak.) Mak. 22 parts, Rhizoma Atractylodis 27 parts, Folium Querci dentatae 22 parts, Periostracum Cicadae 19 parts, Radix Saposhnikoviae 25 parts, Herba elsholtziae luteolae 20 parts, Radix Sophorae Flavescentis 22 parts, Folium rumicis acetosae Farfugium kaemferi 25 parts, Radix Puerariae 30 parts, Stamen Euphorbiae Antiquori 22 parts, Fructus Gardeniae 17 parts, Radix Patriniae heterophyllae 25 parts, Flos Lonicerae 18 parts, Radix Rubi parvifolii 20 parts, Herba Taraxaci 25 parts, Cortex Phellodendri 28 parts, Herba Swertiae erythrostictae 22 parts, Cortex Dictamni 25 parts, Fructus Forsythiae 18 parts, Herba cirsii esculenti 22 parts, Radix Berberidis 25 parts, Herba Andrographis 22 parts, Herba Lobeliae Chinensis 18 parts, Herba Physalis pubescentis 25 parts, 20 parts, Poria, Rhizoma Alismatis 22 parts, Rubus rufolanatus H. T. Chang 25 parts, Polyporus 18 parts, Cortex Periplocae 25 parts, Medulla Tetrapanacis 22 parts, the Fructus Kochiae 30 parts and Flos Micheliae Yunnanensis 20 parts.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Thalictri Ramosi 30 parts, Radix Platycodonis 20 parts, Fructus Arctii 19 parts, match Herba stellariae mediae 15 parts, Herba saussureae nigrescentis 22 parts, Herba Schizonepetae 25 parts, Drymotaenium miyoshianum (Mak.) Mak. 22 parts, Rhizoma Atractylodis 18 parts, Folium Querci dentatae 20 parts, Periostracum Cicadae 25 parts, Radix Saposhnikoviae 30 parts, Herba elsholtziae luteolae 25 parts, Radix Sophorae Flavescentis 28 parts, Folium rumicis acetosae Farfugium kaemferi 20 parts, Radix Puerariae 30 parts, Stamen Euphorbiae Antiquori 22 parts, Fructus Gardeniae 25 parts, Radix Patriniae heterophyllae 18 parts, Flos Lonicerae 20 parts, Radix Rubi parvifolii 30 parts, Herba Taraxaci 27 parts, Cortex Phellodendri 25 parts, Herba Swertiae erythrostictae 26 parts, Cortex Dictamni 30 parts, Fructus Forsythiae 28 parts, Herba cirsii esculenti 25 parts, Radix Berberidis 28 parts, Herba Andrographis 20 parts, Herba Lobeliae Chinensis 25 parts, Herba Physalis pubescentis 19 parts, 20 parts, Poria, Rhizoma Alismatis 25 parts, Rubus rufolanatus H. T. Chang 26 parts, Polyporus 28 parts, Cortex Periplocae 22 parts, Medulla Tetrapanacis 20 parts, the Fructus Kochiae 30 parts and Flos Micheliae Yunnanensis 22 parts.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Thalictri Ramosi 27 parts, Radix Platycodonis 30 parts, Fructus Arctii 25 parts, match Herba stellariae mediae 18 parts, Herba saussureae nigrescentis 25 parts, Herba Schizonepetae 22 parts, Drymotaenium miyoshianum (Mak.) Mak. 28 parts, Rhizoma Atractylodis 25 parts, Folium Querci dentatae 22 parts, Periostracum Cicadae 20 parts, Radix Saposhnikoviae 25 parts, Herba elsholtziae luteolae 22 parts, Radix Sophorae Flavescentis 26 parts, Folium rumicis acetosae Farfugium kaemferi 22 parts, Radix Puerariae 19 parts, Stamen Euphorbiae Antiquori 26 parts, Fructus Gardeniae 18 parts, Radix Patriniae heterophyllae 22 parts, Flos Lonicerae 25 parts, Radix Rubi parvifolii 20 parts, Herba Taraxaci 28 parts, Cortex Phellodendri 18 parts, Herba Swertiae erythrostictae 27 parts, Cortex Dictamni 30 parts, Fructus Forsythiae 25 parts, Herba cirsii esculenti 22 parts, Radix Berberidis 25 parts, Herba Andrographis 20 parts, Herba Lobeliae Chinensis 19 parts, Herba Physalis pubescentis 22 parts, 20 parts, Poria, Rhizoma Alismatis 27 parts, Rubus rufolanatus H. T. Chang 25 parts, Polyporus 17 parts, Cortex Periplocae 20 parts, Medulla Tetrapanacis 26 parts, the Fructus Kochiae 22 parts and Flos Micheliae Yunnanensis 19 parts.

In order to solve the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the medicine of noxious dampness contamination type edema, and wherein, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

When the dosage form of described medicine is tablet, its preparation method comprises the following steps:

The first step, be mixed in proportion by raw medicinal material each in described medicine, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 95%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, by the first step obtain dry cream be placed in super micron mill pulverize 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulates, dry, add relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes tablet.

In order to solve the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the medicine of noxious dampness contamination type edema, and wherein, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

The first step, Herba cirsii esculenti, Radix Berberidis, Herba Andrographis, Herba Lobeliae Chinensis, Herba Physalis pubescentis, Poria, Rhizoma Alismatis, Rubus rufolanatus H. T. Chang, Polyporus, Cortex Periplocae, Medulla Tetrapanacis, the Fructus Kochiae and Flos Micheliae Yunnanensis to be mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stir 60 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtains volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba stellariae mediae, Herba saussureae nigrescentis, Herba Schizonepetae, Drymotaenium miyoshianum (Mak.) Mak., Rhizoma Atractylodis, Folium Querci dentatae, Periostracum Cicadae, Radix Saposhnikoviae, Herba elsholtziae luteolae, Radix Sophorae Flavescentis and Folium rumicis acetosae Farfugium kaemferi will be matched mix in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 75% ~ 95% alcohol reflux 5 ~ 7 times, each 1 ~ 3 hour, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, by except after the raw medicinal material in the first step and second step, remaining raw medicinal material mixes in described ratio, adds relative to mixture 8 ~ 10 times of water gagings, boils 6 ~ 8 hours, filters, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step fully to be mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule, obtain capsule.

In order to solve the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the medicine of noxious dampness contamination type edema, and wherein, when described medicine is oral liquid, its preparation method comprises the following steps:

The first step, by Radix Patriniae heterophyllae, Flos Lonicerae, Radix Rubi parvifolii, Herba Taraxaci, Cortex Phellodendri, Herba Swertiae erythrostictae, Cortex Dictamni, Fructus Forsythiae, Herba cirsii esculenti, Radix Berberidis, Herba Andrographis, Herba Lobeliae Chinensis He Herba Physalis pubescentis mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 75% alcohol reflux 1 time ~ 3 times, each 3 hours ~ 5 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, will except Radix Patriniae heterophyllae, Flos Lonicerae, Radix Rubi parvifolii, Herba Taraxaci, Cortex Phellodendri, Herba Swertiae erythrostictae, Cortex Dictamni, Fructus Forsythiae, Herba cirsii esculenti, Radix Berberidis, Herba Andrographis, Herba Lobeliae Chinensis be with except Herba Physalis pubescentis, remaining raw medicinal material is mixed in proportion, add relative to mixture 3 ~ 5 times of water gagings, boil 2 ~ 4 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

Add ethanol in 4th step, the described dried cream powder that the 3rd step obtained, obtain containing alcohol mastic, the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;

5th step, add cane sugar powder, active carbon by described dealcoholysis mastic, and carry out dilution process, be uniformly mixed to evenly, carry out heat treated, filtration treatment successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, again by the 5th step obtain described semi-finished product carry out filtration treatment, embedding process, sterilization treatment successively, obtain the oral liquid finished product of described medicine.

The invention has the beneficial effects as follows: medicine of the present invention has effect of heat clearing and damp drying, inducing diuresis to remove edema in treatment noxious dampness contamination type edema, mouthfeel is suitable for, patient is easy to accept, and have rapid-action, efficiency is high, determined curative effect, safety are high, have no side effect, treat short treating period, drug effect goes directly focus, not easily produce drug resistance, and processing technology is easy, with low cost, the not easily feature such as recurrence more.

Detailed description of the invention

Chinese medicine is thought, the sick position of edema is dirty at lung, spleen, kidney three, has substantial connection with the heart.Basic disease cause is the logical tune of impairment of dispersing and descending function of the lung, and spleen loses and transfers, and kidney loses folding, and functioning of bladder is not normal, causes water retention in body, spreads unchecked skin.Therefore distinguish that its cause of disease is divided into: attack type outside ailment said due to cold or exposure, noxious dampness contamination type, water wets proofing type, damp and hot interior Sheng type, improper diet and overtiredness type, asthenia of renal qi type; Wherein noxious dampness contamination type: carbuncle and ulcer sore is born in skin, fail removing summer-heat and in return lung spleen, damage of the spleen can not rise Tianjin, and lung wound is lost a surname Yu and fallen, so that in water retention body, spreads unchecked skin, sends out as edema." Prescriptions for Succouring the Sick edema " is called: " have again young, the raw skin ulcer of heat in blood, becomes generalized edema with distention of the chest and abdomen, excessive thirst, oliguria, and this is that heat is swollen.”

Therefore, medicine of the present invention is in treatment noxious dampness contamination type edema, with heat clearing and damp drying, inducing diuresis to remove edema is primary treatment principle, in described medicine, each raw medicinal material is: Herba Thalictri Ramosi, Radix Platycodonis, Fructus Arctii, match Herba stellariae mediae, Herba saussureae nigrescentis, Herba Schizonepetae, Drymotaenium miyoshianum (Mak.) Mak., Rhizoma Atractylodis, Folium Querci dentatae, Periostracum Cicadae, Radix Saposhnikoviae, Herba elsholtziae luteolae, Radix Sophorae Flavescentis, Folium rumicis acetosae Farfugium kaemferi, Radix Puerariae, Stamen Euphorbiae Antiquori, Fructus Gardeniae, Radix Patriniae heterophyllae, Flos Lonicerae, Radix Rubi parvifolii, Herba Taraxaci, Cortex Phellodendri, Herba Swertiae erythrostictae, Cortex Dictamni, Fructus Forsythiae, Herba cirsii esculenti, Radix Berberidis, Herba Andrographis, Herba Lobeliae Chinensis, Herba Physalis pubescentis, Poria, Rhizoma Alismatis, Rubus rufolanatus H. T. Chang, Polyporus, Cortex Periplocae, Medulla Tetrapanacis, the Fructus Kochiae and Flos Micheliae Yunnanensis.

Wherein, the pharmacological property of above-mentioned raw materials medical material is as follows:

Radix Platycodonis: bitter in the mouth, pungent, property is put down.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, effect of filling blood, mending five kinds of over strain, foster the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus." herbal classic " is said: " main chest and hypochondrium as lancination, abdominal distention, borborygmus are faint, gas of throbbing with fear in terror "." Japan hanako materia medica " is said: " mend five kinds of over strain, foster the spirit of nobility, evil removing wards off temperature, tonify deficiency expectorant for all gas lower, only cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, broken lump in the abdomen, and evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat ".Herba Schizonepetae: acrid in the mouth, micro-hardship, property is micro-wet; Enter lung, Liver Channel." Japan hanako materia medica ": " sharp the five internal organs, removing stagnancy of indigested food and making QI downward, relieving alcoholic intoxication.Heat-dissipating of cooking is eaten and is simmered tea, and controls wind syndrome of head and antiperspirant goes out; Semen Glycines preparatum decoct control violent trauma tremble with fear." " detailed outline ": " throat, the skin ulcer that disappears swells for loose wind heat, refresh oneself.Control stiffness of the nape, black flower in order, and raw skin ulcer, cloudy ruined, spit blood, epistaxis, hematochezia, dysentery, metrorrhagia, anal fistula." main cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.Herba Schizonepetae decoct has stronger antibacterial action to staphylococcus aureus and diphtheria corynebacterium.

Fructus Arctii: acrid in the mouth; Bitter; Cold in nature.Return lung; Stomach warp.Can dispelling wind and heat pathogens; Heat-clearing and toxic substances removing rash; Lung qi dispersing sore-throat relieving is loose swollen.Cure mainly anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out not smooth and rubella pruritus; Sore swollen toxin and mumps etc.Raw with can loosening bowel to relieve constipation, pyretic toxicity red swelling and pain of throat, has constipation with heat retention concurrently especially suitable." Bencao Jingshu " is said: " dislike real, for loose wind is except the key medicine of thermal detoxification.Pungent can eliminating stagnation, hardship can expel the heat-evil, and the loose then visceral-qi of accumulation of heat is clear and bright, therefore improving eyesight and invigorating middle warmer.The institute of wind hinders, and defending gas must stop up, stop up then generate heat, Xin Liang dismiss then show gas and, wind without stay.Hide the swollen all flaccidity of device main air poison; The main lung moistening of element, eliminating stagnation gas, sore-throat relieving diaphragm, peeling skin wind, logical twelve channels and collaterals person, know this meaning ear.Therefore in order to control urticaria, variola, especially obtain and very test ".

Rhizoma Atractylodis: nature and flavor: pungent, bitter, temperature.Return spleen, stomach, Liver Channel." pearl sac " day: " stomach invigorating can pacify spleen, non-this of all damp-edema can not remove." Compendium of Material Medica says: " control damp-phlegm prolonged fluid-retention ... and spleen wets dirty, turbid drop leukorrhagia, slides and rushes down hemorrhoidal hamorrhage." " Newly Revised Canon of Materia Medica " claim it can " diuresis ".Cure mainly: the transporting imbalance that the spleen being blocked by dampness causes, inappetence, vomiting is unhappy, and abdominal distention is had loose bowels, arthralgia.For dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.Control dampness taste, and see the thick disease such as turbid of distension and fullness in the abdomen, inappetence, fatigue and weakness, white and greasy fur.

Periostracum Cicadae: sweet, cold; Return lung, Liver Channel.Amplification on Canon of Materia Medica: " control blurred vision nebula.Decocting shell juice again, controlling children's, to go out skin ulcer rash unhappy." Compendium of Material Medica: " controls phlegm-accumulating vertigo, skin wind heat, and varioliform exanthema is had an itch, tetanus and treatment toxic swelling skin ulcer, and adult's aphonia, children's's lockjaw sky hangs, frightened night cry of crying, swelling of the vulva." loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.Periostracum Cicadae each several part all has central nervous system and extensively suppresses usefulness, and alcohol extract has remarkable sedation.

Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature; Enter urinary bladder channel, lung meridian, spleen channel, Liver Channel." Japan hanako materia medica ": " control wind as 36, all labor of man are bad, invigorating middle warmer benefit god, blepharitis marginalis, and arresting lacrimation and paralysis delay, tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse." " Changsha medicine solution ": " network of passing through, by wet excessive, gets round by bribery, and relieve the pain pain, relaxing muscles and tendons arteries and veins, stretches anxious twin, podomere of living, and plays paralysis, holds back spontaneous perspiration, night sweat, break, metrorrhagia." function expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.For affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, and stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of.

Radix Sophorae Flavescentis: bitter in the mouth, cold in nature; Return liver, kidney, large intestine, small intestine meridian, bladder, heart channel, urinary bladder channel." Amplification on Materia Medica addendum ": " Radix Sophorae Flavescentis, can high nourishing YIN gas, or and cause waist severe one, do not rise also because its gas falls, non-meaning of being impairment of the kidney is also.It is controlled strong wind and gains merit, the thin rash of condition wind heat." " book on Chinese herbal medicine is through hundred kinds of records ": " Radix Sophorae Flavescentis, specially controls the fire of heart channel, close with Rhizoma Coptidis function.But Rhizoma Coptidis seemingly goes the fire of heart to be many, Radix Sophorae Flavescentis seemingly goes the fire of heart internal organs small intestinal to be many, then clear with the abnormal smells from the patient of Rhizoma Coptidis, and the abnormal smells from the patient of Radix Sophorae Flavescentis is also turbid.By invigorating middle warmer two word, also get its hardship with the justice of dry spleen also." can heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.

Radix Puerariae: cool in nature, sweet in the mouth, pungent, enter spleen, stomach warp.The famous physician's Li Shizhen (1518-1593 A.D.) of the Ming Dynasty has carried out systematic research to Radix Puerariae, think the stem of Radix Puerariae, leaf, flower, really, root all can be used as medicine.He records like this in Compendium of Material Medica: " Pueraria lobota, property is sweet, pungent, flat, nontoxic, cures mainly: quench one's thirst, high fever of the body, vomiting, all frauds, cloudy gas, separates all poison ".Can yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cure the wound cold, warm headache stiffness of the nape, and dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.

Fructus Gardeniae: bitter, cold, nontoxic; Enter heart channel, Liver Channel, lung meridian, stomach warp, tri-jiao channel.Shennong's Herbal: " pathogen in main five, pathogenic heat in the stomach gas, flushed complexion wine acne vulgaris nose, the red impetigo infections of tuberculoid leprosy." " Mingyi Bielu ": " Great Cold, nontoxic.Cure mainly the hot swelling pain of order, the large heat of breast heart intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas." pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cooling blood for hemostasis.Calentura is vexed, liver-fire conjunctival congestion, and headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprains and swell and ache.This product bitter cold is fallen clearly, can rush down clearly three burnt pathogenic fire, eliminating heart-fire and relieving restlessness, the key medicine that calentura is vexed in order to control, restlessness is not peaceful.There is effect of sharp clearly part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels dampness-heat in the liver and gallbladder, the jaundice of available treating the liver gallbladder retention and fumigation of damp-heat inside the body, oliguria with reddish urine person.The hypotensive activity position of Fructus Gardeniae, at maincenter, mainly strengthens caused by medulla oblongata parasympathetic maincenter tensity.

Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae tea has unique weight losing function simultaneously, can also suppress and the pathogen killing bottleneck throat, have infection effect to old man and child.Herba Taraxaci: nature and flavor are sweet, micro-hardship, cold.Enter spleen, stomach, kidney three warp." Bencao Jingshu ": " Herba Taraxaci is hidden sweet flat, and its property is nontoxic.When being enter stomach into liver, the key medicine of antipyretic removing heat from blood.Acute mastitis belongs to Liver Channel, and married woman is after row, and Liver Channel is taken charge, therefore housewife's human milk carbuncle breast poison, and should give birth to warm good." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " apply all pyogenic infections from tumour or sore, the ruined tinea skin ulcer of scabies; Dispel the wind, disappear all sores, loose scrofula tuberculosis; Stop little having blood in stool, control the five types of stranguria difficulty in urination, sharp bladder." heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Can be used for upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, cholecystitis, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci, simultaneously containing protein, fat, carbohydrate, trace element and vitamin etc., has abundant nutritive value, raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Experiment proves, Herba Taraxaci is to staphylococcus aureus, Hemolytic streptococcus, Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, dysentery bacterium, Bacillus typhi, micrococcus catarrhalis etc., all there is killing action, also have certain inhibitory action to tubercule bacillus, some fungus and virus.Cortex Phellodendri: be the dry bark of rutaceae wampee or Cortex Phellodendri.The former practises title " Cortex Phellodendri ", and the latter practises title " Cortex Phellodendri ".Can be used as medicine, nature and flavor bitter cold, has heat clearing and damp drying, and pathogenic fire purging removes steams, effect of detoxification sore treatment.Cortex Phellodendri is distributed in the area such as Northeast China and North China each province, and happiness is grown among mountain area, assorted woods, and strong adaptability, is applicable to the cultivation of sun-drenched place, also can anti-severe cold.Cortex Phellodendri is common drug, and its cold in nature, bitter in the mouth, the effects such as tool heat clearing and damp drying, eliminating fire and detoxication, are usually used in damp-heat dysentery, jaundice, leucorrhea and the disease such as pyretic arthralgia, pyretic stranguria.Modern study shows, Cortex Phellodendri is containing the main component such as berberine, obacunone, and have the effect of antibacterial, convergence, antiinflammatory, to symptoms such as various skin noxious dampness, skin infection, effect is good." herbal classic is met former " is said: " Cortex Phellodendri, raw with falling excess-fire, processed with wine is controlled in YIN-fire scorching, and salt system controls the inferior the fire of Jiao, and processed with Rhizoma Zingiberis Recens controls middle burnt phlegm-fire, and Sucus Zingberis is fried and blackly controlled damp and hot, and black asthenic fire processed fried by salt wine, deficiency of YIN fire Sheng flushed complexion floating YANG, Radix Aconiti Lateralis Preparata juice system ".

Cortex Dictamni: bitter, salty, cold; Enter spleen channel, lung meridian, small intestine meridian, stomach warp, urinary bladder channel." Mingyi Bielu ": " shaggy-fruited dittany.As if the raw upper valley and dried flank meat.April, May adopt root, dry in the shade." " property of medicine opinion ": " control all pyretic toxicity wind, aversion to wind, wind skin ulcer, scabies are red rotten, and eyebrow loss of hairs is crisp, and musculus cutaneus is anxious, high fever aversion to cold; Principal solution heat is yellow, wine is yellow, acute jaundice, paddy Huang, labor are yellow." Compendium of Material Medica: " Cortex Dictamni, gas is trembled with fear benefaction, and bitter in the mouth is dry, is various jaundice syndromes migratory arthralgia key medicine, and the skin ulcer section that the physicians from a family for generations only execute is shallow." Fructus Forsythiae: bitter in the mouth, cold nature; Enter the heart, lung, small intestine meridian." property of medicine opinion ": " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat." Tang Materia Medica: " Fructus Forsythiae has two kinds, sticks up greatly, Herba Hyperici Erecti.Stick up greatly leaf long and narrow, as Herba Stachydis Japonicae, brightly yellowish lovely, give birth to wetland, work, like the Chinese toon person of not opening in fact, sticks up outstanding grass as room.On the raw hilllock of its Herba Hyperici Erecti is former, Ye Huashi is all carefully little like sticking up greatly, and mountain people from south also uses it.Only with sticking up son greatly under modern capital, without stem flower also." pharmacological action such as have antibacterial, heart tonifying, diuresis, town to tell, be the medicine of heat-clearing and toxic substances removing, cure mainly calentura from the beginning of, anemopyretic cold, heating, vexed, symptom, its bacteriostasis and the Flos Lonicerae broadly similar such as laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus.Weakness of the spleen and stomach, fever due to deficiency of QI, carbuncle is burst, the light person of the rare color of pus avoids clothes.Oleanolic acid contained by this product has heart tonifying, diuresis and hypotensive activity, and Citrin can reduce vascular permeability and fragility, prevents haemolysis.

Radix Berberidis: bitter, cold.Happiness light, resistance to the moon, happiness is loose, rich soil, barren-resistant, strong adaptability.Heat clearing and damp drying, eliminating fire and detoxication.For damp-heat dysentery, jaundice eczema, pharyngalgia conjunctival congestion, Ting discharging ear, carbuncle sore tumefacting virus.Main containing berberine (berberine), palmatine (palmatine palmatine), berbamine (berbamine).Berbamine has remarkable inhibitory action to rat sarcoma W256, share with cyclophosphamide, and effect is added, and both are all strong than alone.Herba Andrographis: have another name called Chun Lianqiuliu, Herba Andrographitis, Lan Helian, Radix Gentianae, golden Rhizoma et radix valerianae, Tremella aurantialba Bandoni et Zang hook, India's grass, Herba vallisneriae Spiralis etc.There are heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external can treat furuncle toxic swelling, trauma infection contamination etc.Herba Andrographis has eliminating inflammation and expelling toxin effect, once multi-infection disease was applied to clinically, comprise trauma infection contamination, furuncle, carbuncle, erysipelas, upper respiratory tract infection, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infection, endometritis, pelvic inflammatory disease, otitis media, periodontitis etc., all have curative effect in various degree.

Herba Lobeliae Chinensis: sweet in the mouth; Property is put down.GUIXIN warp, lung meridian, small intestine meridian." Luchuan book on Chinese herbal medicine ": " detoxicating, relieving inflammation, diuresis, hemostasia and promoting granulation.Control ascites, infantile convulsion, two unilateral tonsillitis, dermatitis rhus, traumatic hemorrhage, skin scabies, Serpentis honeybee scorpion hinders." function heat-clearing and toxic substances removing, inducing diuresis to remove edema.Cure mainly in venom, carbuncle furuncle, tonsillitis, warm rash, tinea pedis, traumatic injury, jaundice due to damp-heat, appendicitis, enteritis, nephritis, cirrhotic ascites and kinds cancer.

Poria: sweet, light is flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness." medication heart method ": " sweet with supporing yang, the panacea of dehumidifying also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, inducing QI of promoting the production of body fluid." modern study shows that the effect that Poria has an enhancing immunity can many-sided regulate immunologic function.Poria has significant inhibitory action to staphylococcus aureus, Bacillus proteus.Concoct: be soaked in water, clean, slightly steam after profit, cut skin and block in time or cut sheet, drying.

Rhizoma Alismatis: sweet in the mouth, light, cold in nature, enter kidney, urinary bladder channel, theory of Chinese medical science thinks that it is cold in nature, has promoting diuresis to eliminate damp pathogen, the lung that clears away heart-fire, rushes down effect of kidney fire.Be mainly used in insufficiency of the spleen retention of water-damp, the wet hydrosarca of spreading unchecked of water; The tired resistance of the heresy of diseases caused by retention of fluid phlegm-damp, what cause that clear YANG failing to ascend voiced sound do not fall is dizzy; The dysuria of damp invasion of lower energizer, red short puckery pain, and the card such as jaundice due to damp-heat.Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Rhizoma Alismatis and preparation modern times thereof are also used for the treatment of auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.

Polyporus: sweet in the mouth, light, flat.Enter the heart, spleen, stomach, lung, kidney, warp.Collective Notes to the Canon of Materia medica note has: " maple Siberian cocklebur, its skin de-black makes block like pig dung, thus with name it.Meat Bai Ershi person is good, with it casting skin of pruning." control dysuria, edema, to have loose bowels, stranguria with turbid discharge, leukorrhagia.Polyporus is the fungus medicinal material that China commonly uses, and the medicinal history of existing more than 2000 year, at home and abroad enjoys high reputation.It not only has diuresis and antibacterial action, finds that there is antitumaous effect after deliberation, and requirement will increase year by year.

Cortex Periplocae: warm in nature, acrid in the mouth, hardship; Return liver, kidney, heart channel." Sichuan medicine will ": " analgesia, except rheumatism.Control anemofrigid-damp arthralgia, the contracture of foot knee joint, bones and muscles pain." wind-damp dispelling, bone and muscle strengthening.For anemofrigid-damp arthralgia, soreness of the waist and knees, shortness of breath and palpitation, edema of lower limbs.

Medulla Tetrapanacis: sweet in the mouth, light, cold nature; Enter lung, stomach warp." Japan hanako materia medica ": " improving eyesight, brings down a fever, and expedites the emergence of, lower eyelid, stimulating milk secretion." " Changsha medicine solution ": " stimulate the menstrual flow and close, treat jaundice, eliminating carbuncle cellulitis, sharp nose carbuncle, except vexed." clear snobbish water, lactogenesis.The puckery pain of main stranguria, dysuria, edema, jaundice, damp-warm diseases, oliguria with reddish urine, puerperal, breast was few, amenorrhea, leukorrhagia.For hygropyrexia dark coloured urine, the puckery pain of gonorrhea, edema oliguria, agalactia.Deficiency of both QI and YIN, interior without the damp and hot and careful clothes of anemia of pregnant woman.The Fructus Kochiae: cold in nature, acrid in the mouth, hardship; Enter kidney, urinary bladder channel." property of medicine opinion ": " with Actinolitum with taking, main husband's impotence does not rise, QI invigorating benefit power; Control cloudy ovum Huang disease, reduce phlegm and internal heat wind, can make soup and take a shower." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " sharp bladder urine accumulated heat, washes the wind of skin, treats married woman all through exopathogenic heat, clear sharp fetal heat in pregnancy, damp-heat vaginal discharge." clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.Fructus Kochiae water logging agent (1:3), all has inhibitory action in various degree to dermatophytess such as being permitted blue achorion, Du's big belly microspore tinea bacterium difficult to understand, rust microspore tinea bacterium, ulotrichy microspore tinea bacterium, star-shaped nocardia in vitro.

Herba Thalictri Ramosi: nature and flavor: bitter, cold.1. " Sichuan medicine will ": " bitter, cold, nontoxic." 2. Guangzhou army " conventional Chinese herbal medicine handbook ": " micro-hardship, cool." cure mainly: heat clearing away, dampness removing, removing toxic substances.Control dysentery, jaundice, conjunctival congestion, carbuncle.1. " conventional glossary of Herbs and Drugs among the people ": " heat-clearing and toxic substances removing.Harness the Yellow River swollen." 2. " Sichuan medicine will ": " controls conjunctival congestion, hematodiarrhoea, jaundice, gastric heat and ascariasis, and subsides a swelling, and dries, and treats lyssodexis." 3. Guangzhou army " conventional Chinese herbal medicine handbook ": " clear late at night improving eyesight.Control acute conjunctivitis, dysentery, infectious hepatitis, suppurative infection."

Herba saussureae nigrescentis: nature and flavor: acrid in the mouth is bitter, cool in nature.Cure mainly: promoting blood flow to regulate menstruation, expelling wind and removing dampness, clearing away heat to improve acuity of vision.Control menoxenia, asthenia hectic fever due to YIN-deficiency, order disease.

Folium Querci dentatae: nature and flavor: Tang Materia Medica: " sweet-bitter flavor is flat, nontoxic." cure mainly: control haematemesis, epistaxis, dysentery, internal hemorrhoid with bleeding, gonorrhea.1. Tang Materia Medica: " main hemorrhoid, hemostasis, dysentery, quenches the thirst." 2. " detailed outline ": " invigorates blood circulation, and diuresis, except on face, Zha is red." 3. " modern practical medicine ": " controls gonorrhea, dark coloured urine, expelling tenia again."

Herba elsholtziae luteolae: Gui Jing: enter lung, stomach, large intestine three warp.Cure mainly: clearing away summer-heat heat, diuresis, except fullness in the chest, reason excessive thirst.Control heatstroke dysentery, generate heat thirsty, vexed hypochondriac pain, halitosis, glossorrhagia.

Stamen Euphorbiae Antiquori: nature and flavor: sweet; Cold.Gui Jing: Liver Channel.Cure mainly: diuresis; Removing toxic substances, main expansion.

Radix Rubi parvifolii: nature and flavor: sweetness and bitterness is flat.1. Guangzhou army " conventional Chinese herbal medicine handbook ": " sweetness and bitterness, cool." 2. " Fujian traditional herbal medicine ": " sweet acid, flat, nontoxic." 3. " Chongqing medical herbs ": " is bitter, flat, nontoxic." cure mainly: heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and detumescence.Cure cold high heat, laryngopharynx swelling and pain, rheumatic arthralgia, hepatitis, dysentery, oedema due to nephritis, urinary tract infection, calculus, and hemoptysis, spits blood, married woman's metrorrhagia, traumatic injury, furuncle swelling toxin.1. " the SHENGCAO property of medicine is standby to be wanted ": " infusing drugs in wine strengthening bone and muscle." 2. " book on Chinese herbal medicine asks former ": " controls scrofula.Fry sustainability, open oil and put furunculosis of the buttock on the skin." 3. " Zhiwu Mingshi Tukao ": " nourishing muscle and tendon is invigorated blood circulation, and disappear red detumescent." 4. " classifying herbal ": " controls haematemesis, irregular menstruation, traumatic injury." 5. " south of the Five Ridges gather medicinal herbs record ": " reason snakebite, flu folder color." 6. " Guizhou side among the people medicine collection ": " antipyretic wind dispelling, dispelling the wind and dampness pathogens pain, demented.Relieving heat toxin, controls furuncle swelling toxin." 7. " Fujian traditional herbal medicine ": " tonifying YIN arresting seminal emission, treats the splenic diarrhea, only dysentery." 8. " Chinese herbal medicine is commonly used in Shanghai ": " heat-clearing and toxic substances removing, promoting blood circulation and detumescence, expelling wind and removing dampness.Cure cold high heat, laryngopharynx swelling and pain, hepatitis, and hemoptysis, spits blood, oedema due to nephritis, urinary tract infection, traumatic injury, rheumatic ostalgia." 9. " will planted by middle traditional Chinese medicines ": " controls chronic hepatitis."

Herba Swertiae erythrostictae: nature and flavor: bitter, cool.Gui Jing: enter the heart, lung, spleen channel.Cure mainly: control that pneumonia, jaundice, syphilis, skin ulcer are swollen, pharyngeal swelling, scabies.

Herba cirsii esculenti: nature and flavor: sweet is cool.Cure mainly: dissipating blood stasis for subsidence of swelling, evacuating pus and expelling toxin by reinforcing QI and blood, hemostasis.Control pulmonary abscess, sore and toxic, dermatosis, liver-heat, various hemorrhage.

Herba Physalis pubescentis: nature and flavor: 1. " Jiangxi traditional herbal medicine proved recipe ": " cold in nature, bitter in the mouth is nontoxic." 2. " Chinese herbal medicine is commonly used in Shanghai ": " acid, flat." cure mainly: heat clearing away, diuresis, removing toxic substances.Cure cold, cough due to lung-heat, laryngopharynx swelling and pain, swelling of the gum, jaundice due to damp-heat, dysentery, edema, pyretic stranguria, pemphigus, furuncle.1. " Jiangxi traditional herbal medicine ": " control pemphigus, infection with swollen head, furuncle of finger, gingival swelling and pain, jaundice due to damp-heat, red swelling and pain of throat, cough due to lung-heat, pyretic stranguria." 2. " Chinese herbal medicine is commonly used in Shanghai ": " heat-clearing and toxic substances removing, diuresis is stopped blooding, dispersing swelling and dissipating binds.Control laryngopharynx swelling and pain.Lung abscess, parotitis; Dysuria, hematuria.Gingival swelling and pain, pemphigus."

Rubus rufolanatus H. T. Chang: nature and flavor: puckery; Flat.Gui Jing: stomach; Bladder; Lung meridian.Cure mainly: astringing to arrest bleeding.Main haematemesis, spitting of blood, hematuria, metrorrhagia, traumatic hemorrhage, operative hemorrhage.

Flos Micheliae Yunnanensis: nature and flavor: cool, puckery micro-hardship.Cure mainly: antiinflammatory, heat clearing away.Control laryngitis, rhinitis, ophthalmia.

Match Herba stellariae mediae: nature and flavor: acid is flat.Cure mainly: detoxification and removing stasis, clearing away heat and promoting diuresis, stimulating milk secretion.Cure mainly hemorrhoid, swell and ache, appendicitis, pyretic stranguria, urinary tract infection.

Drymotaenium miyoshianum (Mak.) Mak.: nature and flavor: sweet; Cool.Gui Jing: liver; Kidney channel.Cure mainly: clearing away heat and relieving the wind syndrome; Invigorate blood circulation.Main infantile convulsion; Impairment caused by overstrain.Folium rumicis acetosae Farfugium kaemferi: nature and flavor: pungent, numb, micro-hardship, heat.Slightly poisonous.Cure mainly: dissipating blood stasis, invigorate blood circulation, pain relieving.Cure mainly traumatic injury, pain caused by ecchymoma, bones and muscles pain due to rheumatism.Radix Patriniae heterophyllae: source: " detailed outline ".Nature and flavor: " Guangxi medicine will ": " acrid in the mouth, warm in nature." return through: " Guangxi medicine will ": " enters the heart, liver two warp." cure mainly: control pyrexial malaria, women's metrorrhagia, leucorrhea with red and white discharge, traumatic injury.1. " book on Chinese herbal medicine is original ": " cure the wound cold, pyrexial malaria." 2. " Henan Arzneibucs ": " foot bath, controls foot pain." 3. " Shanxi medicine will ": " holds back liver dampness, hemostasis.Control married woman's hip cellulitis, leucorrhea with red and white discharge." 4. " Guangxi medicine will ": " blood stasis dispelling, detumescence.Control traumatic injury."

Wherein, in described medicine, the parts by weight of each raw medicinal material can preferably than being Herba Thalictri Ramosi 15-35 part, Radix Platycodonis 10-30 part, Fructus Arctii 15-35 part, match Herba stellariae mediae 10-35 part, Herba saussureae nigrescentis 10-30 part, Herba Schizonepetae 17-35 part, Drymotaenium miyoshianum (Mak.) Mak. 10-30 part, Rhizoma Atractylodis 15-35 part, Folium Querci dentatae 10-25 part, Periostracum Cicadae 15-35 part, Radix Saposhnikoviae 19-35 part, Herba elsholtziae luteolae 17-35 part, Radix Sophorae Flavescentis 10-30 part, Folium rumicis acetosae Farfugium kaemferi 15-35 part, Radix Puerariae 15-35 part, Stamen Euphorbiae Antiquori 17-35 part, Fructus Gardeniae 10-30 part, Radix Patriniae heterophyllae 15-35 part, Flos Lonicerae 10-30 part, Radix Rubi parvifolii 17-35 part, Herba Taraxaci 15-35 part, Cortex Phellodendri 10-30 part, Herba Swertiae erythrostictae 15-35 part, Cortex Dictamni 17-35 part, Fructus Forsythiae 10-30 part, Herba cirsii esculenti 15-35 part, Radix Berberidis 10-30 part, Herba Andrographis 15-30 part, Herba Lobeliae Chinensis 17-30 part, Herba Physalis pubescentis 18-35 part, Poria 10-30 part, Rhizoma Alismatis 15-35 part, Rubus rufolanatus H. T. Chang 18-30 part, Polyporus 10-30 part, Cortex Periplocae 15-35 part, Medulla Tetrapanacis 10-30 part, Fructus Kochiae 15-35 part and Flos Micheliae Yunnanensis 15-30 part.

Wherein, in described medicine, the parts by weight of each raw medicinal material can also preferably than being Herba Thalictri Ramosi 17-30 part, Radix Platycodonis 15-30 part, Fructus Arctii 17-35 part, match Herba stellariae mediae 10-30 part, Herba saussureae nigrescentis 15-30 part, Herba Schizonepetae 17-30 part, Drymotaenium miyoshianum (Mak.) Mak. 15-30 part, Rhizoma Atractylodis 15-30 part, Folium Querci dentatae 16-25 part, Periostracum Cicadae 17-30 part, Radix Saposhnikoviae 20-35 part, Herba elsholtziae luteolae 17-30 part, Radix Sophorae Flavescentis 15-30 part, Folium rumicis acetosae Farfugium kaemferi 15-30 part, Radix Puerariae 17-35 part, Stamen Euphorbiae Antiquori 18-30 part, Fructus Gardeniae 15-30 part, Radix Patriniae heterophyllae 15-30 part, Flos Lonicerae 15-30 part, Radix Rubi parvifolii 18-35 part, Herba Taraxaci 15-30 part, Cortex Phellodendri 16-30 part, Herba Swertiae erythrostictae 18-30 part, Cortex Dictamni 19-35 part, Fructus Forsythiae 15-30 part, Herba cirsii esculenti 17-30 part, Radix Berberidis 15-30 part, Herba Andrographis 15-25 part, Herba Lobeliae Chinensis 17-25 part, Herba Physalis pubescentis 18-30 part, Poria 10-25 part, Rhizoma Alismatis 15-30 part, Rubus rufolanatus H. T. Chang 22-30 part, Polyporus 15-30 part, Cortex Periplocae 15-30 part, Medulla Tetrapanacis 15-30 part, Fructus Kochiae 17-35 part and Flos Micheliae Yunnanensis 18-25 part.

Wherein, in described medicine, the parts by weight of each raw medicinal material also can preferably than being Herba Thalictri Ramosi 20 parts, Radix Platycodonis 18 parts, Fructus Arctii 22 parts, match Herba stellariae mediae 17 parts, Herba saussureae nigrescentis 25 parts, Herba Schizonepetae 20 parts, Drymotaenium miyoshianum (Mak.) Mak. 22 parts, Rhizoma Atractylodis 27 parts, Folium Querci dentatae 22 parts, Periostracum Cicadae 19 parts, Radix Saposhnikoviae 25 parts, Herba elsholtziae luteolae 20 parts, Radix Sophorae Flavescentis 22 parts, Folium rumicis acetosae Farfugium kaemferi 25 parts, Radix Puerariae 30 parts, Stamen Euphorbiae Antiquori 22 parts, Fructus Gardeniae 17 parts, Radix Patriniae heterophyllae 25 parts, Flos Lonicerae 18 parts, Radix Rubi parvifolii 20 parts, Herba Taraxaci 25 parts, Cortex Phellodendri 28 parts, Herba Swertiae erythrostictae 22 parts, Cortex Dictamni 25 parts, Fructus Forsythiae 18 parts, Herba cirsii esculenti 22 parts, Radix Berberidis 25 parts, Herba Andrographis 22 parts, Herba Lobeliae Chinensis 18 parts, Herba Physalis pubescentis 25 parts, 20 parts, Poria, Rhizoma Alismatis 22 parts, Rubus rufolanatus H. T. Chang 25 parts, Polyporus 18 parts, Cortex Periplocae 25 parts, Medulla Tetrapanacis 22 parts, the Fructus Kochiae 30 parts and Flos Micheliae Yunnanensis 20 parts.

Wherein, in described medicine, the parts by weight of each raw medicinal material again can preferably than being Herba Thalictri Ramosi 30 parts, Radix Platycodonis 20 parts, Fructus Arctii 19 parts, match Herba stellariae mediae 15 parts, Herba saussureae nigrescentis 22 parts, Herba Schizonepetae 25 parts, Drymotaenium miyoshianum (Mak.) Mak. 22 parts, Rhizoma Atractylodis 18 parts, Folium Querci dentatae 20 parts, Periostracum Cicadae 25 parts, Radix Saposhnikoviae 30 parts, Herba elsholtziae luteolae 25 parts, Radix Sophorae Flavescentis 28 parts, Folium rumicis acetosae Farfugium kaemferi 20 parts, Radix Puerariae 30 parts, Stamen Euphorbiae Antiquori 22 parts, Fructus Gardeniae 25 parts, Radix Patriniae heterophyllae 18 parts, Flos Lonicerae 20 parts, Radix Rubi parvifolii 30 parts, Herba Taraxaci 27 parts, Cortex Phellodendri 25 parts, Herba Swertiae erythrostictae 26 parts, Cortex Dictamni 30 parts, Fructus Forsythiae 28 parts, Herba cirsii esculenti 25 parts, Radix Berberidis 28 parts, Herba Andrographis 20 parts, Herba Lobeliae Chinensis 25 parts, Herba Physalis pubescentis 19 parts, 20 parts, Poria, Rhizoma Alismatis 25 parts, Rubus rufolanatus H. T. Chang 26 parts, Polyporus 28 parts, Cortex Periplocae 22 parts, Medulla Tetrapanacis 20 parts, the Fructus Kochiae 30 parts and Flos Micheliae Yunnanensis 22 parts.

Wherein, in described medicine, the parts by weight of each raw medicinal material again can preferably than being Herba Thalictri Ramosi 27 parts, Radix Platycodonis 30 parts, Fructus Arctii 25 parts, match Herba stellariae mediae 18 parts, Herba saussureae nigrescentis 25 parts, Herba Schizonepetae 22 parts, Drymotaenium miyoshianum (Mak.) Mak. 28 parts, Rhizoma Atractylodis 25 parts, Folium Querci dentatae 22 parts, Periostracum Cicadae 20 parts, Radix Saposhnikoviae 25 parts, Herba elsholtziae luteolae 22 parts, Radix Sophorae Flavescentis 26 parts, Folium rumicis acetosae Farfugium kaemferi 22 parts, Radix Puerariae 19 parts, Stamen Euphorbiae Antiquori 26 parts, Fructus Gardeniae 18 parts, Radix Patriniae heterophyllae 22 parts, Flos Lonicerae 25 parts, Radix Rubi parvifolii 20 parts, Herba Taraxaci 28 parts, Cortex Phellodendri 18 parts, Herba Swertiae erythrostictae 27 parts, Cortex Dictamni 30 parts, Fructus Forsythiae 25 parts, Herba cirsii esculenti 22 parts, Radix Berberidis 25 parts, Herba Andrographis 20 parts, Herba Lobeliae Chinensis 19 parts, Herba Physalis pubescentis 22 parts, 20 parts, Poria, Rhizoma Alismatis 27 parts, Rubus rufolanatus H. T. Chang 25 parts, Polyporus 17 parts, Cortex Periplocae 20 parts, Medulla Tetrapanacis 26 parts, the Fructus Kochiae 22 parts and Flos Micheliae Yunnanensis 19 parts.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 tablet

The manufacturing process of oral medicine tablet of the present invention is: get Herba Thalictri Ramosi 2000g, Radix Platycodonis 1800g, Fructus Arctii 2200g, match Herba stellariae mediae 1700g, Herba saussureae nigrescentis 2500g, Herba Schizonepetae 2000g, Drymotaenium miyoshianum (Mak.) Mak. 2200g, Rhizoma Atractylodis 2700g, Folium Querci dentatae 2200g, Periostracum Cicadae 1900g, Radix Saposhnikoviae 2500g, Herba elsholtziae luteolae 2000g, Radix Sophorae Flavescentis 2200g, Folium rumicis acetosae Farfugium kaemferi 2500g, Radix Puerariae 3000g, Stamen Euphorbiae Antiquori 2200g, Fructus Gardeniae 1700g, Radix Patriniae heterophyllae 2500g, Flos Lonicerae 1800g, Radix Rubi parvifolii 2000g, Herba Taraxaci 2500g, Cortex Phellodendri 2800g, Herba Swertiae erythrostictae 2200g, Cortex Dictamni 2500g, Fructus Forsythiae 1800g, Herba cirsii esculenti 2200g, Radix Berberidis 2500g, Herba Andrographis 2200g, Herba Lobeliae Chinensis 1800g, Herba Physalis pubescentis 2500g, Poria 2000g, Rhizoma Alismatis 2200g, Rubus rufolanatus H. T. Chang 2500g, Polyporus 1800g, Cortex Periplocae 2500g, Medulla Tetrapanacis 2200g, Fructus Kochiae 3000g and Flos Micheliae Yunnanensis 2000g,

The first step, be mixed in proportion by raw medicinal material each in described medicine, adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 85%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, by the first step obtain dry cream be placed in super micron mill pulverize 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, the micropowders obtained by second step, add relative to the microcrystalline Cellulose of its quality 0.2 times, 0.15 times of lactose, the starch of 0.2 times, sieve, mix homogeneously, granulate, dry, add relative to micropowders quality 0.009 times of magnesium stearate, granulate, tabletting, makes tablet.

Embodiment 2 capsule

The manufacturing process of oral medicine capsule of the present invention is: get Herba Thalictri Ramosi 3000g, Radix Platycodonis 2000g, Fructus Arctii 1900g, match Herba stellariae mediae 1500g, Herba saussureae nigrescentis 2200g, Herba Schizonepetae 2500g, Drymotaenium miyoshianum (Mak.) Mak. 2200g, Rhizoma Atractylodis 1800g, Folium Querci dentatae 2000g, Periostracum Cicadae 2500g, Radix Saposhnikoviae 3000g, Herba elsholtziae luteolae 2500g, Radix Sophorae Flavescentis 2800g, Folium rumicis acetosae Farfugium kaemferi 2000g, Radix Puerariae 3000g, Stamen Euphorbiae Antiquori 2200g, Fructus Gardeniae 2500g, Radix Patriniae heterophyllae 1800g, Flos Lonicerae 2000g, Radix Rubi parvifolii 3000g, Herba Taraxaci 2700g, Cortex Phellodendri 2500g, Herba Swertiae erythrostictae 2600g, Cortex Dictamni 3000g, Fructus Forsythiae 2800g, Herba cirsii esculenti 2500g, Radix Berberidis 2800g, Herba Andrographis 2000g, Herba Lobeliae Chinensis 2500g, Herba Physalis pubescentis 1900g, Poria 2000g, Rhizoma Alismatis 2500g, Rubus rufolanatus H. T. Chang 2600g, Polyporus 2800g, Cortex Periplocae 2200g, Medulla Tetrapanacis 2000g, Fructus Kochiae 3000g and Flos Micheliae Yunnanensis 2200g,

The first step, Herba cirsii esculenti, Radix Berberidis, Herba Andrographis, Herba Lobeliae Chinensis, Herba Physalis pubescentis, Poria, Rhizoma Alismatis, Rubus rufolanatus H. T. Chang, Polyporus, Cortex Periplocae, Medulla Tetrapanacis, the Fructus Kochiae and Flos Micheliae Yunnanensis to be mixed in described ratio, add the water extraction volatile oil relative to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 5, stir 80 minutes, temperature 40 DEG C, obtains volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.16;

Second step, Herba stellariae mediae, Herba saussureae nigrescentis, Herba Schizonepetae, Drymotaenium miyoshianum (Mak.) Mak., Rhizoma Atractylodis, Folium Querci dentatae, Periostracum Cicadae, Radix Saposhnikoviae, Herba elsholtziae luteolae, Radix Sophorae Flavescentis and Folium rumicis acetosae Farfugium kaemferi will be matched mix in described ratio, add relative to mixture 7 times amount determining alcohol be 80% alcohol reflux 6 times, each 2 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.21, for subsequent use;

3rd step, by except after the raw medicinal material in the first step and second step, remaining raw medicinal material mixes in described ratio, adds relative to mixture 9 times of water gagings, boils 7 hours, filters, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 70 DEG C of reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step fully to be mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 6 weight portion carboxymethyl starch sodium, 45 weight starch mix homogeneously, adding 200 weight portion determining alcohols is 85% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 4 weight portion magnesium stearate, then load in gelatine capsule, obtain capsule.

Embodiment 3 oral liquid

The manufacturing process of oral medicine oral liquid of the present invention is: get Herba Thalictri Ramosi 2700g, Radix Platycodonis 3000g, Fructus Arctii 2500g, match Herba stellariae mediae 1800g, Herba saussureae nigrescentis 2500g, Herba Schizonepetae 2200g, Drymotaenium miyoshianum (Mak.) Mak. 2800g, Rhizoma Atractylodis 2500g, Folium Querci dentatae 2200g, Periostracum Cicadae 2000g, Radix Saposhnikoviae 2500g, Herba elsholtziae luteolae 2200g, Radix Sophorae Flavescentis 2600g, Folium rumicis acetosae Farfugium kaemferi 2200g, Radix Puerariae 1900g, Stamen Euphorbiae Antiquori 2600g, Fructus Gardeniae 1800g, Radix Patriniae heterophyllae 2200g, Flos Lonicerae 2500g, Radix Rubi parvifolii 2000g, Herba Taraxaci 2800g, Cortex Phellodendri 1800g, Herba Swertiae erythrostictae 2700g, Cortex Dictamni 3000g, Fructus Forsythiae 2500g, Herba cirsii esculenti 2200g, Radix Berberidis 2500g, Herba Andrographis 2000g, Herba Lobeliae Chinensis 1900g, Herba Physalis pubescentis 2200g, Poria 2000g, Rhizoma Alismatis 2700g, Rubus rufolanatus H. T. Chang 2500g, Polyporus 1700g, Cortex Periplocae 2000g, Medulla Tetrapanacis 2600g, Fructus Kochiae 2200g and Flos Micheliae Yunnanensis 1900g,

The first step, by Radix Patriniae heterophyllae, Flos Lonicerae, Radix Rubi parvifolii, Herba Taraxaci, Cortex Phellodendri, Herba Swertiae erythrostictae, Cortex Dictamni, Fructus Forsythiae, Herba cirsii esculenti, Radix Berberidis, Herba Andrographis, Herba Lobeliae Chinensis He Herba Physalis pubescentis mixing, add relative to mixture 4 times amount determining alcohol be 65% alcohol reflux 2 times, each 4 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.31, for subsequent use;

Second step, will except Radix Patriniae heterophyllae, Flos Lonicerae, Radix Rubi parvifolii, Herba Taraxaci, Cortex Phellodendri, Herba Swertiae erythrostictae, Cortex Dictamni, Fructus Forsythiae, Herba cirsii esculenti, Radix Berberidis, Herba Andrographis, Herba Lobeliae Chinensis be with except Herba Physalis pubescentis, remaining raw medicinal material is mixed in proportion, add relative to mixture 5 times of water gagings, boil 3 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;

3rd step, the described mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder;

Add ethanol in 4th step, the described dried cream powder that the 3rd step obtained, obtain containing alcohol mastic, the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 35 hours;

5th step, add cane sugar powder, active carbon by described dealcoholysis mastic, and carry out dilution process, be uniformly mixed to evenly, carry out heat treated, filtration treatment successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.002; The time of described heat treated is 30 minutes, and temperature is 110 DEG C;

Long term toxicity test:

Respectively by tablet prepared by the embodiment of the present invention 1, capsule prepared by embodiment 2, Oral Liquid On Mice prepared by embodiment 3 is all by 10.78, 20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: medicine of the present invention is to the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Acute toxicity testing:

Application NIH mice 80, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into four groups at random, often organizes 20, i.e. matched group and administration group (embodiment group 1, embodiment group 2, embodiment group 3), fasting 12 hours before experiment; Capsule prepared by tablet embodiments of the invention group 1 prepared respectively, embodiment group 2 and oral liquid prepared by embodiment group 3 and water dissolution Homogeneous phase mixing, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage medicine LD50>32.9 crude drug/kg of the present invention, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage medicine of the present invention is 901 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.

Clinical treatment:

Case selection: fetch patient 232 example coming from the court and suffer from noxious dampness contamination type edema, man 165 example, female 67 example; 20 ~ 65 years old age; The patient 232 examples being suffered from noxious dampness contamination type edema is divided into tablet in treatment group, capsule treatment group, oral liquid treatment group and matched group, each experimental group 58 people at random.

The patient clinical symptom main manifestations that 232 examples suffer from noxious dampness contamination type edema is: body sends out desolation, very then fester, or pharyngitis, or tonsillitis enlargement pain, continue the then puffiness of the eyes, prolong and whole body, dysuria, appearance and extremity edema, sores ulceration of skin carbuncle, fever with aversion to wind, red tongue, yellow and thin fur, floating and rapid pulse or sliding number.

Therapeutic Method:

In medication therapy groups:

Tablet in treatment group: take the embodiment of the present invention 1 prepare tablet, every day 3 times, one time 4, within every 60 days, be 1 course for the treatment of;

Capsule treatment group: take the embodiment of the present invention 2 prepare capsule, every day 3 times, one time 2, within every 60 days, be a course for the treatment of;

Oral liquid treatment group: take oral liquid prepared by the embodiment of the present invention 3, every day 3 times, 30ml/ time every 60 days is a course for the treatment of.

Matched group: take triamterene hydrochlorothiazide tablet, every day 2 times, each 1 every 60 days is a course for the treatment of.

Diagnostic criteria:

Formulate with reference to " internal medicine edema disease " diagnostic criteria: (1) has the puffiness of the eyes, prolongs and whole body, dysuria, appearance and extremity edema, sores ulceration of skin carbuncle, fever with aversion to wind pathological changes; (2) there is health to send out desolation, very then fester, or pharyngitis, or tonsillitis enlargement pain, red tongue, yellow and thin fur, floating and rapid pulse or sliding number; (3) the visible pharyngitis of x-ray plain film, red tongue, yellow and thin fur.And hope according to the traditional Chinese medical science, hear, ask, cut and be dialectically diagnosed as noxious dampness contamination type edema further.

The standard of curative effect evaluation:

Efficacy assessment standard according to noxious dampness contamination type edema in " disease of tcm Standardization of diagnosis and curative effect " is formulated.

(1) fully recover: edema all disappears, and body sends out desolation, very then festers, or pharyngitis, or tonsillitis enlargement pain, continue the then puffiness of the eyes, dysuria, appearance and extremity edema, sores ulceration of skin carbuncle, fever with aversion to wind, red tongue, the transference cures such as yellow and thin fur, floating and rapid pulse or sliding number;

(2) effective: edema and body send out desolation, very then fester, or pharyngitis, or tonsillitis enlargement pain, continue the then puffiness of the eyes, dysuria, appearance and extremity edema, sores ulceration of skin carbuncle, fever with aversion to wind, red tongue, the symptoms such as yellow and thin fur, floating and rapid pulse or sliding number alleviate more than 50%;

(3) effective: edema and body send out desolation, very then fester, or pharyngitis, or tonsillitis enlargement pain, continue the then puffiness of the eyes, dysuria, appearance and extremity edema, sores ulceration of skin carbuncle, fever with aversion to wind, red tongue, the symptoms such as yellow and thin fur, floating and rapid pulse or sliding number alleviate 50%;

(4) invalid: edema and body send out desolation, very then fester, or pharyngitis, or tonsillitis enlargement pain, continue the then puffiness of the eyes, dysuria, appearance and extremity edema, sores ulceration of skin carbuncle, fever with aversion to wind, red tongue, the symptoms such as yellow and thin fur, floating and rapid pulse or sliding number are unchanged or have and increase the weight of.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt medicine of the present invention in treatment noxious dampness contamination type edema, relative to conventional medicament on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy noxious dampness contamination type edema of the present invention, relative to conventional medicament, treatment the course for the treatment of on significantly shorten.

After table 1 liang group treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine

Group	Number of cases	Recovery from illness number	Effective number	Significant figure	Invalid number	Recovery from illness, aobvious and effective percentage (%)
							Tablet in treatment group	58	42	15	1	0	100％
Capsule treatment group	58	46	10	1	1	98.3％
							Oral liquid treatment group	58	44	12	2	0	100％
Matched group	58	13	17	22	6	89.7％

Table 2 Four composition does not treat recovery from illness and effective number and time comparative example (%) after 4 courses for the treatment of

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of	4th course for the treatment of
						Tablet in treatment group	57	7（12.3％）	10（17.5％）	17（29.8％）	23（40.4％）
Capsule treatment group	56	8（14.3％）	11（19.6％）	18（32.1％）	19（33.9％）
						Oral liquid treatment group	56	7（12.5％）	12（21.4％）	16（28.6％）	21（37.5％）
Matched group	30	0（0％）	3（10％）	7（23.3％）	20（66.7％）

According to the clinical statistics in above table, medicine of the present invention in treatment noxious dampness contamination type edema, have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; Simultaneously to 169 examples of the recovery from illness of tablet in treatment group, capsule treatment group and oral liquid treatment group and effective number and matched group recovery from illness and effective 53 routine follow-up of patients 1 year half, result is added up, fully recover in 42 examples without recurring in the recovery from illness of tablet in treatment group and effective number 57 example, 1 case relapsed in effective 15 examples, relapse rate is 1.7%; Fully recover without recurrence in 46 examples in the recovery from illness of capsule treatment group and effective number 56 example, recur 2 routine in effective 10 examples, relapse rate is 3.5%; Fully recover in the recovery from illness of oral liquid treatment group and effective number 56 example recurrence 1 in 44 examples, recur 2 routine in effective 12 examples, relapse rate is 5.3%; 30 examples of matched group recovery from illness and effective number, in 13 routine patients of recovery from illness, recurrence 9 example, in effective 17 routine patients, recurs 15 people, relapse rate 80%; Above-mentioned recurrence refer to patient outcomes reach recovery from illness or effective after, in 1 year half of following up a case by regular visits to, obviously there is the appearance before treatment and extremity edema, sores ulceration of skin carbuncle, fever with aversion to wind, red tongue, yellow and thin fur, the symptoms such as floating and rapid pulse.

Model case: Liu, male, 59 years old, because of the extremity edema several months, also with fever with aversion to wind symptom, is tentatively judged as edema on inspection, and hopes according to the traditional Chinese medical science, hears, asks, cuts dialectical being diagnosed as further as noxious dampness contamination type edema.Take the tablet of Medications Example 1 of the present invention, every day 3 times, each 4, treat 2 months effectively, continue to take medicine 2 months effective, follow up a case by regular visits to and do not recur for 1 year half.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the medicine of noxious dampness contamination type edema for one kind, it is characterized in that, comprise following raw medicinal material: Herba Thalictri Ramosi, Radix Platycodonis, Fructus Arctii, match Herba stellariae mediae, Herba saussureae nigrescentis, Herba Schizonepetae, Drymotaenium miyoshianum (Mak.) Mak., Rhizoma Atractylodis, Folium Querci dentatae, Periostracum Cicadae, Radix Saposhnikoviae, Herba elsholtziae luteolae, Radix Sophorae Flavescentis, Folium rumicis acetosae Farfugium kaemferi, Radix Puerariae, Stamen Euphorbiae Antiquori, Fructus Gardeniae, Radix Patriniae heterophyllae, Flos Lonicerae, Radix Rubi parvifolii, Herba Taraxaci, Cortex Phellodendri, Herba Swertiae erythrostictae, Cortex Dictamni, Fructus Forsythiae, Herba cirsii esculenti, Radix Berberidis, Herba Andrographis, Herba Lobeliae Chinensis, Herba Physalis pubescentis, Poria, Rhizoma Alismatis, Rubus rufolanatus H. T. Chang, Polyporus, Cortex Periplocae, Medulla Tetrapanacis, the Fructus Kochiae and Flos Micheliae Yunnanensis.

2. the medicine for the treatment of noxious dampness contamination type edema according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Thalictri Ramosi 15-35 part, Radix Platycodonis 10-30 part, Fructus Arctii 15-35 part, match Herba stellariae mediae 10-35 part, Herba saussureae nigrescentis 10-30 part, Herba Schizonepetae 17-35 part, Drymotaenium miyoshianum (Mak.) Mak. 10-30 part, Rhizoma Atractylodis 15-35 part, Folium Querci dentatae 10-25 part, Periostracum Cicadae 15-35 part, Radix Saposhnikoviae 19-35 part, Herba elsholtziae luteolae 17-35 part, Radix Sophorae Flavescentis 10-30 part, Folium rumicis acetosae Farfugium kaemferi 15-35 part, Radix Puerariae 15-35 part, Stamen Euphorbiae Antiquori 17-35 part, Fructus Gardeniae 10-30 part, Radix Patriniae heterophyllae 15-35 part, Flos Lonicerae 10-30 part, Radix Rubi parvifolii 17-35 part, Herba Taraxaci 15-35 part, Cortex Phellodendri 10-30 part, Herba Swertiae erythrostictae 15-35 part, Cortex Dictamni 17-35 part, Fructus Forsythiae 10-30 part, Herba cirsii esculenti 15-35 part, Radix Berberidis 10-30 part, Herba Andrographis 15-30 part, Herba Lobeliae Chinensis 17-30 part, Herba Physalis pubescentis 18-35 part, Poria 10-30 part, Rhizoma Alismatis 15-35 part, Rubus rufolanatus H. T. Chang 18-30 part, Polyporus 10-30 part, Cortex Periplocae 15-35 part, Medulla Tetrapanacis 10-30 part, Fructus Kochiae 15-35 part and Flos Micheliae Yunnanensis 15-30 part.

3. the medicine for the treatment of noxious dampness contamination type edema according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Thalictri Ramosi 17-30 part, Radix Platycodonis 15-30 part, Fructus Arctii 17-35 part, match Herba stellariae mediae 10-30 part, Herba saussureae nigrescentis 15-30 part, Herba Schizonepetae 17-30 part, Drymotaenium miyoshianum (Mak.) Mak. 15-30 part, Rhizoma Atractylodis 15-30 part, Folium Querci dentatae 16-25 part, Periostracum Cicadae 17-30 part, Radix Saposhnikoviae 20-35 part, Herba elsholtziae luteolae 17-30 part, Radix Sophorae Flavescentis 15-30 part, Folium rumicis acetosae Farfugium kaemferi 15-30 part, Radix Puerariae 17-35 part, Stamen Euphorbiae Antiquori 18-30 part, Fructus Gardeniae 15-30 part, Radix Patriniae heterophyllae 15-30 part, Flos Lonicerae 15-30 part, Radix Rubi parvifolii 18-35 part, Herba Taraxaci 15-30 part, Cortex Phellodendri 16-30 part, Herba Swertiae erythrostictae 18-30 part, Cortex Dictamni 19-35 part, Fructus Forsythiae 15-30 part, Herba cirsii esculenti 17-30 part, Radix Berberidis 15-30 part, Herba Andrographis 15-25 part, Herba Lobeliae Chinensis 17-25 part, Herba Physalis pubescentis 18-30 part, Poria 10-25 part, Rhizoma Alismatis 15-30 part, Rubus rufolanatus H. T. Chang 22-30 part, Polyporus 15-30 part, Cortex Periplocae 15-30 part, Medulla Tetrapanacis 15-30 part, Fructus Kochiae 17-35 part and Flos Micheliae Yunnanensis 18-25 part.

4. the medicine of the treatment noxious dampness contamination type edema according to any one of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Thalictri Ramosi 20 parts, Radix Platycodonis 18 parts, Fructus Arctii 22 parts, match Herba stellariae mediae 17 parts, Herba saussureae nigrescentis 25 parts, Herba Schizonepetae 20 parts, Drymotaenium miyoshianum (Mak.) Mak. 22 parts, Rhizoma Atractylodis 27 parts, Folium Querci dentatae 22 parts, Periostracum Cicadae 19 parts, Radix Saposhnikoviae 25 parts, Herba elsholtziae luteolae 20 parts, Radix Sophorae Flavescentis 22 parts, Folium rumicis acetosae Farfugium kaemferi 25 parts, Radix Puerariae 30 parts, Stamen Euphorbiae Antiquori 22 parts, Fructus Gardeniae 17 parts, Radix Patriniae heterophyllae 25 parts, Flos Lonicerae 18 parts, Radix Rubi parvifolii 20 parts, Herba Taraxaci 25 parts, Cortex Phellodendri 28 parts, Herba Swertiae erythrostictae 22 parts, Cortex Dictamni 25 parts, Fructus Forsythiae 18 parts, Herba cirsii esculenti 22 parts, Radix Berberidis 25 parts, Herba Andrographis 22 parts, Herba Lobeliae Chinensis 18 parts, Herba Physalis pubescentis 25 parts, 20 parts, Poria, Rhizoma Alismatis 22 parts, Rubus rufolanatus H. T. Chang 25 parts, Polyporus 18 parts, Cortex Periplocae 25 parts, Medulla Tetrapanacis 22 parts, the Fructus Kochiae 30 parts and Flos Micheliae Yunnanensis 20 parts.

5. the medicine of the treatment noxious dampness contamination type edema according to any one of claim 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Thalictri Ramosi 30 parts, Radix Platycodonis 20 parts, Fructus Arctii 19 parts, match Herba stellariae mediae 15 parts, Herba saussureae nigrescentis 22 parts, Herba Schizonepetae 25 parts, Drymotaenium miyoshianum (Mak.) Mak. 22 parts, Rhizoma Atractylodis 18 parts, Folium Querci dentatae 20 parts, Periostracum Cicadae 25 parts, Radix Saposhnikoviae 30 parts, Herba elsholtziae luteolae 25 parts, Radix Sophorae Flavescentis 28 parts, Folium rumicis acetosae Farfugium kaemferi 20 parts, Radix Puerariae 30 parts, Stamen Euphorbiae Antiquori 22 parts, Fructus Gardeniae 25 parts, Radix Patriniae heterophyllae 18 parts, Flos Lonicerae 20 parts, Radix Rubi parvifolii 30 parts, Herba Taraxaci 27 parts, Cortex Phellodendri 25 parts, Herba Swertiae erythrostictae 26 parts, Cortex Dictamni 30 parts, Fructus Forsythiae 28 parts, Herba cirsii esculenti 25 parts, Radix Berberidis 28 parts, Herba Andrographis 20 parts, Herba Lobeliae Chinensis 25 parts, Herba Physalis pubescentis 19 parts, 20 parts, Poria, Rhizoma Alismatis 25 parts, Rubus rufolanatus H. T. Chang 26 parts, Polyporus 28 parts, Cortex Periplocae 22 parts, Medulla Tetrapanacis 20 parts, the Fructus Kochiae 30 parts and Flos Micheliae Yunnanensis 22 parts.

6. the medicine of the treatment noxious dampness contamination type edema according to any one of claim 1-5, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Thalictri Ramosi 27 parts, Radix Platycodonis 30 parts, Fructus Arctii 25 parts, match Herba stellariae mediae 18 parts, Herba saussureae nigrescentis 25 parts, Herba Schizonepetae 22 parts, Drymotaenium miyoshianum (Mak.) Mak. 28 parts, Rhizoma Atractylodis 25 parts, Folium Querci dentatae 22 parts, Periostracum Cicadae 20 parts, Radix Saposhnikoviae 25 parts, Herba elsholtziae luteolae 22 parts, Radix Sophorae Flavescentis 26 parts, Folium rumicis acetosae Farfugium kaemferi 22 parts, Radix Puerariae 19 parts, Stamen Euphorbiae Antiquori 26 parts, Fructus Gardeniae 18 parts, Radix Patriniae heterophyllae 22 parts, Flos Lonicerae 25 parts, Radix Rubi parvifolii 20 parts, Herba Taraxaci 28 parts, Cortex Phellodendri 18 parts, Herba Swertiae erythrostictae 27 parts, Cortex Dictamni 30 parts, Fructus Forsythiae 25 parts, Herba cirsii esculenti 22 parts, Radix Berberidis 25 parts, Herba Andrographis 20 parts, Herba Lobeliae Chinensis 19 parts, Herba Physalis pubescentis 22 parts, 20 parts, Poria, Rhizoma Alismatis 27 parts, Rubus rufolanatus H. T. Chang 25 parts, Polyporus 17 parts, Cortex Periplocae 20 parts, Medulla Tetrapanacis 26 parts, the Fructus Kochiae 22 parts and Flos Micheliae Yunnanensis 19 parts.

7. the medicine of the treatment noxious dampness contamination type edema according to any one of claim 1-6, it is characterized in that, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

8. the preparation method of the medicine of the treatment noxious dampness contamination type edema according to any one of claim 1-6, it is characterized in that, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

9. the medicine of the treatment noxious dampness contamination type edema according to any one of claim 1-6, it is characterized in that, when described medicine is oral liquid, its preparation method comprises the following steps: