CN104587416A - Traditional Chinese medicinal composition for treating early hepatocirrhosis - Google Patents
Traditional Chinese medicinal composition for treating early hepatocirrhosis Download PDFInfo
- Publication number
- CN104587416A CN104587416A CN201510084448.0A CN201510084448A CN104587416A CN 104587416 A CN104587416 A CN 104587416A CN 201510084448 A CN201510084448 A CN 201510084448A CN 104587416 A CN104587416 A CN 104587416A
- Authority
- CN
- China
- Prior art keywords
- radix
- minutes
- parts
- minute
- add
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicinal composition for treating early hepatocirrhosis. The traditional Chinese medicinal composition is prepared from the following raw medicaments in parts by weight: 12 to 17 parts of gardenia, 13 to 16 parts of cassia twigs, 8 to 15 parts of bergamots, 12 to 18 parts of polyporus umbellatus, 13 to 16 parts of radix paeoniae rubra, 5 to 14 parts of rosa davurica pall, 7 to 15 parts of Chinese thorowax roots, 11 to 16 parts of curcuma aromatica, 5 to 9 parts of phyllanthus urinaria, 15 to 20 parts of angelica, 9 to 16 parts of raspberries, 12 to 18 parts of astractylodes lancea, 11 to 18 parts of sophora flavescens and 12 to 20 parts of wolfiporia extensa. The traditional Chinese medicinal composition has the effects of clearing heat, causing diuresis, nourishing liver, strengthening spleen, promoting blood circulation and removing blood stasis, is high in recovery rate, and has remarkable therapeutic effects.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine composition for the treatment of early stage liver cirrhosis.
Background technology
Liver cirrhosis is clinical common chronic, Progressive symmetric erythrokeratodermia hepatopathy, is the diffusivity hepatic injury that, repeated action long-term by one or more causes of disease is formed.Hepatic fibrosis is the basis of pathogenesis of cirrhosis.The main pathogenesis of liver cirrhosis is Progressive symmetric erythrokeratodermia fibrosis.The collagen (I and III type) of normal liver tissue interstitial is mainly distributed in around portal area and central vein.I type and III collagen type showed increased during liver cirrhosis and calm in lobule everywhere.Along with the continuous deposition of collagen protein in sinusoid, fenestra of endothelial cell obviously reduces, and makes sinus hepaticus develop into blood capillary gradually, causes mass exchange obstacle between blood and hepatocyte.A large amount of collagens of liver cirrhosis are from the fat-storing cell (Ito cell) being positioned at sinusoid (Disse chamber), and this hyperplasia enlivens, and can change into fibroblast like cell.Though when the fibrous tissue of initial stage hypertrophy forms little bar rope but is not yet connected to each other formation interval and reconstructs lobules of liver structure, be called hepatic fibrosis.If continue progress, the fibrous septum at the places such as centrilobular district and portal area will be connected to each other, and make lobules of liver structure and blood circulation reconstruct and form liver cirrhosis.Because early stage liver cirrhosis is clinically without any specific sings and symptoms, therefore be in the subclinical pathological change stage, but there is part early stage liver cirrhosis patient can have following symptom: (1) early stage liver cirrhosis General Symptoms: to mainly contain weak, easy tired, strength dissolved.Face's pigmentation can be there is in the early stage liver of minority [1] sclerosis patient.(2) early stage liver cirrhosis chronic indigestion symptom: food poor appetite moves back, abdominal distention or companion's constipation, diarrhoea or dull pain in liver, after tired obviously.(3) early stage liver cirrhosis sign: the visible spider angioma of a few patients, the light to moderate enlargement of liver, is more common in alcoholic cirrhosis patient, general without tenderness.Spleen can normally or silght enlargement.The effective medicine of clinical still shortage generally recognized as safe, generally can fill various vitamin and can improve hepatocyte metabolism as injection Vitamin B_6 and vitamin B group etc. at present, prevents Steatosis and the hepatocellular effect of protection, also can take yeast tablet.Take the circumstances into consideration vitimin supplement K, B12 and folic acid.Secondly the hepatocellular medicine of protection can also be taken.
Publication No. CN 103055285 A(application number 201210573551.8) Chinese patent literature disclose a kind of Chinese medicine for the treatment of early stage liver cirrhosis and preparation method thereof, this Chinese medicine Fructus Evodiae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Codonopsis, Ramulus Cinnamomi, Colla Corii Asini, Cortex Moutan, Rhizoma Zingiberis Recens, Radix Glycyrrhizae, Rhizoma Pinelliae Preparatum, Radix Ophiopogonis, Radix Bupleuri, Fructus Aurantii Immaturus, Poria.Publication No. CN 103100045 A(application number 201210559141.8) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of early stage liver cirrhosis, belong to the field of Chinese medicines.It is made up of the crude drug of following weight parts: Herba Lycopi 12, Rhizoma Polygoni Cuspidati 10, Radix Codonopsis 15, Rhizoma Dioscoreae 12, Rhizoma Sparganii 10, Rhizoma Curcumae 9, Endothelium Corneum Gigeriae Galli 8, Fructus Ligustri Lucidi 10, Placenta Hominis 9, Radix Vladimiriae 12, Ramulus Cinnamomi 12, Folium Mori 8, Rhizoma Arisaematis 8, Caulis Spatholobi 12.Publication No. CN 102441141 A(application number 201110390729.0) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of early stage liver cirrhosis, be made up of the raw material of following parts by weight: the Radix Astragali 2 parts, the Radix Paeoniae Alba 3 parts, Rhizoma Polygoni Cuspidati 3 parts, Herba Leonuri 3 parts, Hirudo 2 parts, Radix Salviae Miltiorrhizae 4 parts, Radix Curcumae 2 parts, Fructus Crataegi 4 parts and large skin skin 2 parts, have the effect adjusting tonifying liver spleen, blood circulation promoting and blood stasis dispelling.
In modern medicine, the medicine that western medical treatment uses is cured the symptoms, not the disease, dependency and side effect larger, comparatively speaking, Chinese traditional treatment is more safe and effective, current traditional Chinese medical science formula has much, but its suitability and concrete curative effect still to be tested, so also need the research further strengthened this aspect Chinese medicine.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take the wide a kind of Chinese medicine composition for the treatment of early stage liver cirrhosis of safe and applicable.
Technical scheme of the present invention is:
Treat a Chinese medicine composition for early stage liver cirrhosis, be prepared from primarily of following bulk drugs, be weight portion: Fructus Gardeniae 12-17; Ramulus Cinnamomi 13-16; Fructus Citri Sarcodactylis 8-15; Polyporus 12-18; Radix Paeoniae Rubra 13-16; Flos Rosae Davuricae 5-14; Radix Bupleuri 7-15; Radix Curcumae 11-16; Cacumen Securinegae Suffruticosae 5-9; Radix Angelicae Sinensis 15-20; Fructus Rubi 9-16; Rhizoma Atractylodis 12-18; Radix Sophorae Flavescentis 11-18; Poria 12-20.
Preferably, Fructus Gardeniae 13-16; Ramulus Cinnamomi 14-15; Fructus Citri Sarcodactylis 10-13; Polyporus 14-16; Radix Paeoniae Rubra 14-15; Flos Rosae Davuricae 7-12; Radix Bupleuri 9-13; Radix Curcumae 12-15; Cacumen Securinegae Suffruticosae 6-8; Radix Angelicae Sinensis 16-19; Fructus Rubi 11-14; Rhizoma Atractylodis 14-16; Radix Sophorae Flavescentis 13-16; Poria 14-18.
More preferably, Fructus Gardeniae 14.5; Ramulus Cinnamomi 14.5; Fructus Citri Sarcodactylis 11.5; Polyporus 15; Radix Paeoniae Rubra 14.5; Flos Rosae Davuricae 9.5; Radix Bupleuri 11; Radix Curcumae 13.5; Cacumen Securinegae Suffruticosae 7; Radix Angelicae Sinensis 17.5; Fructus Rubi 12.5; Rhizoma Atractylodis 15; Radix Sophorae Flavescentis 14.5; Poria 16.
Described a kind of Chinese medicine composition for the treatment of early stage liver cirrhosis, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 25-35 minute (preferred: Steam by water bath 30 minutes), takes out, adds Mel and mix thoroughly, put into pot, explodes and turns yellow to surface, drain oil, cool with deep fat;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 15-35 minute (preferably: 20-30 minute is steamed in vinegar fumersion with vinegar fumersion; Be more preferably: vinegar fumersion steams 25 minutes), taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, add clear water after rinse and soak 15 minutes, big fire is heated to boiling, continues 10 minutes, add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae again, turn little fire and decoct 30-50 minute (preferably: little fire decocts 35-45 minute; Be more preferably: turn little fire and decoct 40 minutes), filter, obtain filtrate;
(4) by step (3) remaining filtering residue, add the water of boiled crude drug 5 times, continue decoction 30 minutes, filter to get filtrate, merge twice gained filtrate;
(5) made to step (1) (2) crude drug is pulverized, is added in step (4) gained filtrate, is concentrated into relative density 1.28(70 DEG C) thick paste, obtain unguentum.
Described a kind of preparation method for the treatment of the Traditional Chinese medicine composition paste of early stage liver cirrhosis, adds in step (3) 6-8 times (preferred: to add 7 times that clear water amount is boiled crude drug weight) that clear water amount is boiled crude drug weight.
Described a kind of Chinese medicine composition for the treatment of early stage liver cirrhosis, be made into pharmaceutically acceptable granule, its preparation method is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 25-35 minute (preferred: Steam by water bath 30 minutes), takes out, adds Mel and mix thoroughly, put into pot, explodes and turns yellow to surface, drain oil, cool with deep fat;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 15-35 minute (preferably: 20-30 minute is steamed in vinegar fumersion with vinegar fumersion; Be more preferably: vinegar fumersion steams 25 minutes), taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, the clear water adding boiled crude drug 6 times after rinse soaks 15 minutes, big fire is heated to boiling, continue 10 minutes, add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae again, turn little fire and decoct 30-50 minute (preferably: little fire decocts 35-45 minute; Be more preferably: turn little fire and decoct 40 minutes), filter, obtain filtrate;
(4) by step (3) gained filtrate spraying dry, pulverize and sieve together with step (1) (2) gained crude drug, add wetting agent after mixing and make hands and pinch agglomerating, namely the loose soft material of pressure, is pressed through 16 mesh sieves, obtains single-size, dry at 65 DEG C, packaging, obtains granule.
Described a kind of preparation method for the treatment of the Chinese medicinal composition granules of early stage liver cirrhosis, pulverized 60-100 mesh sieve (preferred: to pulverize 70-90 mesh sieve in step (4); Be more preferably: pulverized 80 mesh sieves).
Described a kind of Chinese medicine composition for the treatment of early stage liver cirrhosis, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 25-35 minute (preferred: Steam by water bath 30 minutes), takes out, adds Mel and mix thoroughly, put into pot, explodes and turns yellow to surface, drain oil, cool with deep fat;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 15-35 minute (preferably: 20-30 minute is steamed in vinegar fumersion with vinegar fumersion; Be more preferably: vinegar fumersion steams 25 minutes), taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, the clear water adding boiled crude drug weight 6 times after rinse soaks 15 minutes, and big fire is heated to boiling, continue 10 minutes, then add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae, turn little fire and decoct, filter, obtain filtrate;
(4) by step (3) remaining filtering residue, add the water of boiled crude drug 5 times, continue to decoct 20-30 minute (preferably: continue to decoct 22-28 minute; Be more preferably: continue decoction 25 minutes), filter to get filtrate, merge twice gained filtrate;
(5) pulverized by made to step (1) (2) crude drug, be added in step (4) gained filtrate, heating is concentrated into the half of original volume, obtains decoction.
Described a kind of preparation method for the treatment of the Chinese medicine composition decoction of early stage liver cirrhosis, the little fire of step (3) transfer decocts 30-40 minute (preferably: turn little fire and decoct 32-38 minute; Be more preferably: turn little fire and decoct 35 minutes).
Described a kind of Chinese medicine composition for the treatment of early stage liver cirrhosis, be made into pharmaceutically acceptable honeyed pill, its preparation method is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 25-35 minute (preferred: Steam by water bath 30 minutes), takes out, adds Mel and mix thoroughly, put into pot, explodes and turns yellow to surface, drain oil, cool with deep fat;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 15-35 minute (preferably: 20-30 minute is steamed in vinegar fumersion with vinegar fumersion; Be more preferably: vinegar fumersion steams 25 minutes), taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, the clear water adding boiled crude drug weight 6 times after rinse soaks 15 minutes, big fire is heated to boiling, continue 10 minutes, add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae again, turn little fire and decoct 30-50 minute (preferably: little fire decocts 35-45 minute; Be more preferably: turn little fire and decoct 40 minutes), filter, obtain filtrate;
(4) heat concentration step (3) gained filtrate to clear paste, pulverized by made to step (1) (2) crude drug, mix homogeneously with clear paste, add adjuvant refined honey, make plasticity agglomerate, rubbing, segmentation, round, drying, packaging, obtain honeyed pill.
Described a kind of preparation method for the treatment of the Chinese medicine composition honeyed pill of early stage liver cirrhosis, the amount adding adjuvant refined honey in step (4) is the 0.5-0.7 of clear paste weight doubly (preferred: the amount adding adjuvant refined honey is 0.6 times of clear paste weight).
A kind of Traditional Chinese medicine composition formula science for the treatment of early stage liver cirrhosis provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, gained Chinese medicine composition of the present invention has effect of clearing away heat and promoting diuresis, nourishing the liver spleen invigorating, blood circulation promoting and blood stasis dispelling;
2, Chinese crude drug safe without toxic side effect selected by the present invention, cheap, do not increase patient economy burden;
3, this prescription forms according to clinical empirical summary, and cure rate is high, evident in efficacy, the suitability is wide.
Accompanying drawing explanation
Figure 1 shows that treatments period, two groups of normal number of cases changes of patient's liver function recovery.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat a Chinese medicine composition for early stage liver cirrhosis, be prepared from primarily of following bulk drugs, every part of 10g: Fructus Gardeniae 12 parts, Ramulus Cinnamomi 13 parts, Fructus Citri Sarcodactylis 8 parts, Polyporus 12 parts, Radix Paeoniae Rubra 13 parts, Flos Rosae Davuricae 5 parts, Radix Bupleuri 7 parts, Radix Curcumae 11 parts, Cacumen Securinegae Suffruticosae 5 parts, Radix Angelicae Sinensis 15 parts, Fructus Rubi 9 parts, Rhizoma Atractylodis 12 parts, Radix Sophorae Flavescentis 11 parts, 12 parts, Poria.Above-mentioned a kind of preparation method for the treatment of the Traditional Chinese medicine composition paste of early stage liver cirrhosis is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 30 minutes, take out, add Mel and mix thoroughly, put into pot, explode with deep fat and turn yellow to surface, drain oil, cool;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 25 minutes with vinegar fumersion, taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, the clear water adding boiled crude drug weight 7 times after rinse soaks 15 minutes, and big fire is heated to boiling, continue 10 minutes, then add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae, turn little fire and decoct 40 minutes, filter, obtain filtrate;
(4) by step (3) remaining filtering residue, add the water of boiled crude drug 5 times, continue decoction 30 minutes, filter to get filtrate, merge twice gained filtrate;
(5) made to step (1) (2) crude drug is pulverized, is added in step (4) gained filtrate, is concentrated into relative density 1.28(70 DEG C) thick paste, obtain unguentum.
embodiment 2treat a Chinese medicine composition for early stage liver cirrhosis, be prepared from primarily of following bulk drugs, every part of 10g: Fructus Gardeniae 17 parts, Ramulus Cinnamomi 16 parts, Fructus Citri Sarcodactylis 15 parts, Polyporus 18 parts, Radix Paeoniae Rubra 16 parts, Flos Rosae Davuricae 14 parts, Radix Bupleuri 15 parts, Radix Curcumae 16 parts, Cacumen Securinegae Suffruticosae 9 parts, Radix Angelicae Sinensis 20 parts, Fructus Rubi 16 parts, Rhizoma Atractylodis 18 parts, Radix Sophorae Flavescentis 18 parts, 20 parts, Poria.Above-mentioned a kind of preparation method for the treatment of the Chinese medicinal composition granules of early stage liver cirrhosis is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 30 minutes, take out, add Mel and mix thoroughly, put into pot, explode with deep fat and turn yellow to surface, drain oil, cool;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 25 minutes with vinegar fumersion, taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, the clear water adding boiled crude drug 6 times after rinse soaks 15 minutes, and big fire is heated to boiling, continue 10 minutes, then add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae, turn little fire and decoct 40 minutes, filter, obtain filtrate;
(4) by step (3) gained filtrate spraying dry, pulverized 80 mesh sieves together with step (1) (2) gained crude drug, and added wetting agent after mixing and make hands and pinch agglomerating, namely the loose soft material of pressure, is pressed through 16 mesh sieves, obtains single-size, dry at 65 DEG C, packaging, obtains granule.
Model case: xxx, male, 51 years old.Medical history: patient suffered from hepatitis before 3 years, after hospitalize, liver function recovery is normal, recent sensation myasthenia of limbs, anorexia, sleep are poor, and pressing hepatic region tingle, removes examination in hospital, B ultrasonic display hepatomegaly, Echoenhance, uneven, be diagnosed as early stage liver cirrhosis.
Take this example gained Chinese medicinal composition granules, each 2-4g, one day twice, one after each meal, within 15 days, be a course for the treatment of, after patient takes two courses for the treatment of, malaise symptoms improves, adhere to taking five courses for the treatment of, symptom is all eliminated, and liver function recovery is normal on inspection, after drug withdrawal, follow up a case by regular visits in 1 year, without recurrence.
embodiment 3treat a Chinese medicine composition for early stage liver cirrhosis, be prepared from primarily of following bulk drugs, every part of 10g: Fructus Gardeniae 13 parts, Ramulus Cinnamomi 14 parts, Fructus Citri Sarcodactylis 10 parts, Polyporus 14 parts, Radix Paeoniae Rubra 14 parts, Flos Rosae Davuricae 7 parts, Radix Bupleuri 9 parts, Radix Curcumae 12 parts, Cacumen Securinegae Suffruticosae 6 parts, Radix Angelicae Sinensis 16 parts, Fructus Rubi 11 parts, Rhizoma Atractylodis 14 parts, Radix Sophorae Flavescentis 13 parts, 14 parts, Poria.Above-mentioned a kind of preparation method for the treatment of the Chinese medicine composition decoction of early stage liver cirrhosis is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 30 minutes, take out, add Mel and mix thoroughly, put into pot, explode with deep fat and turn yellow to surface, drain oil, cool;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 25 minutes with vinegar fumersion, taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, the clear water adding boiled crude drug weight 6 times after rinse soaks 15 minutes, and big fire is heated to boiling, continue 10 minutes, then add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae, turn little fire and decoct 35 minutes, filter, obtain filtrate;
(4) by step (3) remaining filtering residue, add the water of boiled crude drug 5 times, continue decoction 25 minutes, filter to get filtrate, merge twice gained filtrate;
(5) pulverized by made to step (1) (2) crude drug, be added in step (4) gained filtrate, heating is concentrated into the half of original volume, obtains decoction.
Model case: xxx, women, 42 years old.Medical history: before 10 years, patient finds to suffer from hepatitis B when unit health check-up, by diagnoses and treatment, effect is not satisfactory, a presensation autodigestion ability decline in month, abdominal part swelling, slight constipation, and period is with low grade fever's phenomenon, remove examination in hospital, B ultrasonic display liver density promotes, and has hepatic ascites, transaminase disorder, hepatitis B inspection has two to be positive, and is diagnosed as hepatitis B and turns early stage liver cirrhosis and abnormal liver function.
Listen people to introduce treatment by Chinese herbs more safe and effective, take this example gained Chinese medicine composition decoction, each 80-100ml(decides as circumstances require), one day twice, one after each meal 15 days is a course for the treatment of, after patient takes one month, hepatic ascites disappears completely, clinical symptom relief, can slightly work, and holds on again after taking four courses for the treatment of, liver function index inspection is normal, and hepatitis B virus DNA is turned out cloudy.
embodiment 4treat a Chinese medicine composition for early stage liver cirrhosis, be prepared from primarily of following bulk drugs, every part of 10g: Fructus Gardeniae 16 parts, Ramulus Cinnamomi 15 parts, Fructus Citri Sarcodactylis 13 parts, Polyporus 16 parts, Radix Paeoniae Rubra 15 parts, Flos Rosae Davuricae 12 parts, Radix Bupleuri 13 parts, Radix Curcumae 15 parts, Cacumen Securinegae Suffruticosae 8 parts, Radix Angelicae Sinensis 19 parts, Fructus Rubi 14 parts, Rhizoma Atractylodis 16 parts, Radix Sophorae Flavescentis 16 parts, 18 parts, Poria.Above-mentioned a kind of preparation method for the treatment of the Chinese medicine composition honeyed pill of early stage liver cirrhosis is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 30 minutes, take out, add Mel and mix thoroughly, put into pot, explode with deep fat and turn yellow to surface, drain oil, cool;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 25 minutes with vinegar fumersion, taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, the clear water adding boiled crude drug weight 6 times after rinse soaks 15 minutes, and big fire is heated to boiling, continue 10 minutes, then add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae, turn little fire and decoct 40 minutes, filter, obtain filtrate;
(4) heat concentration step (3) gained filtrate to clear paste, made to step (1) (2) crude drug is pulverized, mixs homogeneously with clear paste, add the adjuvant refined honey of clear paste weight 0.6 times, make plasticity agglomerate, rubbing, segmentation, round, drying, packaging, obtain honeyed pill.
Model case: xxx, male, 55 years old.Medical history: patient the year before, occurs distension and fullness in the abdomen, fatigue and weakness, the symptom of dry mouth with bitter taste, examination in hospital liver function slight abnormality, CT shows hepatosplenomegaly, rough surface is uneven, and liver echo significantly strengthens, be diagnosed as early stage liver cirrhosis, withdrawal after treatment transference cure, over nearly two months, the state of an illness increases the weight of suddenly, abdominal distention unbearably, edema of the limbs, appetite is poor, and western medicine is without obvious curative effects.
Take this example gained Chinese medicine composition honeyed pill upon somebody's introduction, each 3-4 ball, one day twice, one after each meal 15 days is a course for the treatment of, after patient takes one week, symptom starts to take a turn for the better, abdominal distention alleviates, and appetite strengthens, after adhering to taking three courses for the treatment of, symptomatology is eliminated, can normally work, after consolidating a course for the treatment of, time examination in hospital liver function recovery is normal.
embodiment 5treat a Chinese medicine composition for early stage liver cirrhosis, be prepared from primarily of following bulk drugs, every part of 10g: Fructus Gardeniae 14.5 parts, Ramulus Cinnamomi 14.5 parts, Fructus Citri Sarcodactylis 11.5 parts, Polyporus 15 parts, Radix Paeoniae Rubra 14.5 parts, Flos Rosae Davuricae 9.5 parts, Radix Bupleuri 11 parts, Radix Curcumae 13.5 parts, Cacumen Securinegae Suffruticosae 7 parts, Radix Angelicae Sinensis 17.5 parts, Fructus Rubi 12.5 parts, Rhizoma Atractylodis 15 parts, Radix Sophorae Flavescentis 14.5 parts, 16 parts, Poria.Above-mentioned a kind of preparation method for the treatment of the Traditional Chinese medicine composition paste of early stage liver cirrhosis is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 30 minutes, take out, add Mel and mix thoroughly, put into pot, explode with deep fat and turn yellow to surface, drain oil, cool;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 25 minutes with vinegar fumersion, taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, the clear water adding boiled crude drug weight 7 times after rinse soaks 15 minutes, and big fire is heated to boiling, continue 10 minutes, then add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae, turn little fire and decoct 40 minutes, filter, obtain filtrate;
(4) by step (3) remaining filtering residue, add the water of boiled crude drug 5 times, continue decoction 30 minutes, filter to get filtrate, merge twice gained filtrate;
(5) made to step (1) (2) crude drug is pulverized, is added in step (4) gained filtrate, is concentrated into relative density 1.28(70 DEG C) thick paste, obtain unguentum.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Gardeniae: bitter in the mouth, cold in nature.Have pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, effect of removing pathogenic heat from blood and toxic substance from the body, vexed for calentura, heat in blood tells nosebleed, conjunctival congestion and swelling pain.
Ramulus Cinnamomi: base is former: be the twig of canella Cortex Cinnamomi.Nature and flavor with return through acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Function with cure mainly: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Fructus Citri Sarcodactylis: base is former: be the fruit of rutaceae Fructus Citri Sarcodactylis.Chemical analysis: containing citropten. 0.007% in dry fruit; Also containing daflon and the hesperidin of trace.Nature and flavor: arduous acid, temperature.Gui Jing: enter liver, stomach warp.Function cures mainly: regulate the flow of vital energy, and reduces phlegm.Treat for stomachache, coerce swollen, vomiting, dysphagic, phlegm retention cough with asthma, and can relieve the effect of alcohol.
Polyporus: base is former: be the dry sclerotia of Polyporaceae plant Polyporus.Chemical analysis: containing ergosterol, biotin, saccharide, protein.Nature and flavor: sweet light are flat.Gui Jing: enter spleen, kidney, urinary bladder channel.Function cures mainly: diuresis eliminating dampness by diuresis.Control dysuria, edema distension, beriberi, has loose bowels, drench, turbid, leukorrhagia.
Radix Paeoniae Rubra: base is former: the root of Paeoniaceae plant peony, CHUANSHAO medicine, Paeonia obovata Maxim., hair leaf Paeonia obovata Maxim., Paeonia mairei Lévl., Paeonia anomala and tuber Radix Paeoniae.Nature and flavor: bitter; Be slightly cold.Gui Jing: liver; Spleen channel.Function cures mainly: clearing away heat and cooling blood; Blood circulation promoting and blood stasis dispelling.Main maculae caused by violent heat pathogen; Hematemesis and epistaxis; Discharging fresh blood stool; Conjunctival congestion and swelling pain; Carbuncle skin infection; Amenorrhea; Dysmenorrhea; Metrorrhagia and leukorrhagia stranguria with turbid discharge; The stagnant hypochondriac pain of the stasis of blood; Hernia abdominal mass is gathered; Injury from falling down.
Flos Rosae Davuricae: base is former: be the flower of rosaceous plant Rosa bella.Nature and flavor: acid; Sweet; Flat.Gui Jing: liver; Spleen channel.Function cures mainly: regulating qi-flowing for harmonizing stomach; Cough-relieving.Main menoxenia, dysmenorrhea, metrorrhagia, spits blood, intercostal neuralgia, pulmonary tuberculosis cough.
Radix Bupleuri: nature and flavor with return through, pungent, bitter, be slightly cold.Return liver, gallbladder, lung meridian.Evacuation is had to bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, effect of elevate a turnable ladder yang-energy.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
Radix Curcumae: base is former: be the tuber of zingiberaceous plant Rhizoma Curcumae Longae, Radix Curcumae or Rhizoma Curcumae.Property pungent, bitter, cold.Return liver, the heart, lung meridian.Can regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be generally used for amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Cacumen Securinegae Suffruticosae: base is former: be Euphorbiaceae phyllanthus emblica platymiscium Cacumen Securinegae Suffruticosae, with all herbal medicine.Nature and flavor: micro-hardship, sweet, cool.Function cures mainly: clearing away heat and promoting diuresis, improving eyesight, removing food stagnancy.For oedema due to nephritis, urinary system infection, calculus, enteritis, dysentery, young waiter in a wineshop or an inn's infantile malnutrition, eye keratitis, icterohepatitis; External is controlled Trimeresurus stejnegeri and is bitten.
Radix Angelicae Sinensis: nature and flavor with return through sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Fructus Rubi: base is former: for the dry fruit of basin is covered in Rosaceae rubus East China
.nature and flavor with return through: sweet, sour, temperature.Return liver, kidney, urinary bladder channel.Function with cure mainly: supplementing the kidney to control the nocturnal reducing urination, nourishing the liver to improve visual acuity.For emission and spermatorrhea, enuresis frequent micturition, impotence and premature ejaculation, order is secretly dim-sighted.
Rhizoma Atractylodis: base is former: be the rhizome of feverfew RHIZOMA ATRACTYLODIS IANCEAE or Atractylis chinensis etc.Nature and flavor: arduous, temperature.Gui Jing: enter spleen, stomach warp.Function cures mainly: spleen invigorating, dampness, resolving depression, wards off dirty.Control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, and seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.
Radix Sophorae Flavescentis: nature and flavor with return through: bitter, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel.There is heat clearing and damp drying, parasite killing, effect of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.
Poria: base is former: be the dry sclerotia of Polyporaceae plant Poria.Nature and flavor with return through: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, effect of mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
test example 1a kind of clinical practice for the treatment of the Chinese medicine composition (embodiment 5) of early stage liver cirrhosis of gained of the present invention:
Choose crowd: in June ,-2014 in March, 2013, be diagnosed as patient 356 example of early stage liver cirrhosis four hospital's screenings, wherein women 177 example, male 179 example, the range of age 30-70 year, the mean age is 40.5 ± 4.3 years old, course of disease 1-10, average course of disease 4 ± 2.6 years.The diagnostic criteria of early stage liver cirrhosis: 1, liver function normally or may have mile abnormality.2, liver fiber four checks that the overwhelming majority has obvious exception.3, HBV-DNA checks there is virus replication.4, liver ultrasound investigation: in liver, blood vessel display is unintelligible, and inner diameter of portal vein >=1.3cm, thickness of spleen is greater than 4.0cm, liver edge angle rust.
Before test, patient is divided into two groups at random, experimental group 240 example and matched group 116 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group takes gained unguentum of the present invention, each 10-15g, one after each meal, one day twice, within 15 days, is a course for the treatment of; Matched group takes other conventional medicines (sunflower liver-protecting tablet, FUFANG BIEJIA RUANGAN PIAN, silybin or Transmetil etc.).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) is effective: clinical symptoms disappears completely, and liver spleen obviously bounces back or stablizes constant, and liver function recovery is normal, and drug withdrawal is not recurred in half a year; (2) effective: clinical symptoms substantially disappears or alleviates, and liver spleen is stablized constant, and liver function is obviously improved, drug withdrawal occasionally has recurrence in half a year; (3) invalid: before and after treatment, symptom, sign and liver function are all not improved or increase the weight of to worsen.
Clinical effectiveness: after the taking medicine of four courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
As shown in Table 1, the total effective rate of experimental group is 97.9%, far above the total effective rate 79.3% of matched group, a kind of better effects if for the treatment of the traditional Chinese medicine composition for treating early stage liver cirrhosis of early stage liver cirrhosis of gained of the present invention is described.
Treatments period, two groups of normal number of cases of patient's liver function recovery change as shown in Figure 1:
Can be obtained by Fig. 1 analysis, the recovery situation of the patient of experimental group, obviously faster than matched group, illustrates gained Chinese medicine composition short treating period of the present invention, cures fast.
Chinese medicine selected in this prescription, there is the Fructus Gardeniae of clearing away heat and promoting diuresis, the Ramulus Cinnamomi of promoting the flow of QI-blood by warming the meridian, the Fructus Citri Sarcodactylis of activating QI to eliminate phlegm, the Polyporus of diuresis eliminating dampness by diuresis, the Radix Paeoniae Rubra of blood circulation promoting and blood stasis dispelling, the Flos Rosae Davuricae of regulating qi-flowing for harmonizing stomach, the Radix Bupleuri of dispersing the stagnated live-QI to relieve the stagnation of QI, the Radix Curcumae of promoting the function of the gallbladder to alleviate jaundice, the Cacumen Securinegae Suffruticosae of clearing away heat and promoting diuresis, the Fructus Rubi of the enrich blood Radix Angelicae Sinensis of invigorating blood circulation, nourishing the liver to improve visual acuity, the Rhizoma Atractylodis of the spleen strengthening and damp drying, the Radix Sophorae Flavescentis of diuresis dampness, the Poria of promoting diuresis to eliminate damp pathogen, plurality of raw materials medicine is arranged in pairs or groups mutually, coordinative role, effectively can alleviate the malaise symptoms of liver cirrhosis patient, improve liver function, shorten treatment time.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat a Chinese medicine composition for early stage liver cirrhosis, it is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Fructus Gardeniae 12-17; Ramulus Cinnamomi 13-16; Fructus Citri Sarcodactylis 8-15; Polyporus 12-18; Radix Paeoniae Rubra 13-16; Flos Rosae Davuricae 5-14; Radix Bupleuri 7-15; Radix Curcumae 11-16; Cacumen Securinegae Suffruticosae 5-9; Radix Angelicae Sinensis 15-20; Fructus Rubi 9-16; Rhizoma Atractylodis 12-18; Radix Sophorae Flavescentis 11-18; Poria 12-20.
2. a kind of Chinese medicine composition for the treatment of early stage liver cirrhosis as claimed in claim 1, is characterized in that, Fructus Gardeniae 13-16; Ramulus Cinnamomi 14-15; Fructus Citri Sarcodactylis 10-13; Polyporus 14-16; Radix Paeoniae Rubra 14-15; Flos Rosae Davuricae 7-12; Radix Bupleuri 9-13; Radix Curcumae 12-15; Cacumen Securinegae Suffruticosae 6-8; Radix Angelicae Sinensis 16-19; Fructus Rubi 11-14; Rhizoma Atractylodis 14-16; Radix Sophorae Flavescentis 13-16; Poria 14-18(is preferably: Fructus Gardeniae 14.5; Ramulus Cinnamomi 14.5; Fructus Citri Sarcodactylis 11.5; Polyporus 15; Radix Paeoniae Rubra 14.5; Flos Rosae Davuricae 9.5; Radix Bupleuri 11; Radix Curcumae 13.5; Cacumen Securinegae Suffruticosae 7; Radix Angelicae Sinensis 17.5; Fructus Rubi 12.5; Rhizoma Atractylodis 15; Radix Sophorae Flavescentis 14.5; Poria 16).
3. a kind of Chinese medicine composition for the treatment of early stage liver cirrhosis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 25-35 minute (preferred: Steam by water bath 30 minutes), takes out, adds Mel and mix thoroughly, put into pot, explodes and turns yellow to surface, drain oil, cool with deep fat;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 15-35 minute (preferably: 20-30 minute is steamed in vinegar fumersion with vinegar fumersion; Be more preferably: vinegar fumersion steams 25 minutes), taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, add clear water after rinse and soak 15 minutes, big fire is heated to boiling, continues 10 minutes, add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae again, turn little fire and decoct 30-50 minute (preferably: little fire decocts 35-45 minute; Be more preferably: turn little fire and decoct 40 minutes), filter, obtain filtrate;
(4) by step (3) remaining filtering residue, add the water of boiled crude drug 5 times, continue decoction 30 minutes, filter to get filtrate, merge twice gained filtrate;
(5) made to step (1) (2) crude drug is pulverized, is added in step (4) gained filtrate, is concentrated into relative density 1.28(70 DEG C) thick paste, obtain unguentum.
4. a kind of preparation method for the treatment of the Traditional Chinese medicine composition paste of early stage liver cirrhosis as claimed in claim 3, it is characterized in that, add in step (3) 6-8 times (preferred: to add 7 times that clear water amount is boiled crude drug weight) that clear water amount is boiled crude drug weight.
5. a kind of Chinese medicine composition for the treatment of early stage liver cirrhosis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable granule, its preparation method is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 25-35 minute (preferred: Steam by water bath 30 minutes), takes out, adds Mel and mix thoroughly, put into pot, explodes and turns yellow to surface, drain oil, cool with deep fat;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 15-35 minute (preferably: 20-30 minute is steamed in vinegar fumersion with vinegar fumersion; Be more preferably: vinegar fumersion steams 25 minutes), taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, the clear water adding boiled crude drug 6 times after rinse soaks 15 minutes, big fire is heated to boiling, continue 10 minutes, add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae again, turn little fire and decoct 30-50 minute (preferably: little fire decocts 35-45 minute; Be more preferably: turn little fire and decoct 40 minutes), filter, obtain filtrate;
(4) by step (3) gained filtrate spraying dry, pulverize and sieve together with step (1) (2) gained crude drug, add wetting agent after mixing and make hands and pinch agglomerating, namely the loose soft material of pressure, is pressed through 16 mesh sieves, obtains single-size, dry at 65 DEG C, packaging, obtains granule.
6. a kind of preparation method for the treatment of the Chinese medicinal composition granules of early stage liver cirrhosis as claimed in claim 5, is characterized in that, pulverizes 60-100 mesh sieve (preferred: to pulverize 70-90 mesh sieve in step (4); Be more preferably: pulverized 80 mesh sieves).
7. a kind of Chinese medicine composition for the treatment of early stage liver cirrhosis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 25-35 minute (preferred: Steam by water bath 30 minutes), takes out, adds Mel and mix thoroughly, put into pot, explodes and turns yellow to surface, drain oil, cool with deep fat;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 15-35 minute (preferably: 20-30 minute is steamed in vinegar fumersion with vinegar fumersion; Be more preferably: vinegar fumersion steams 25 minutes), taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, the clear water adding boiled crude drug weight 6 times after rinse soaks 15 minutes, and big fire is heated to boiling, continue 10 minutes, then add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae, turn little fire and decoct, filter, obtain filtrate;
(4) by step (3) remaining filtering residue, add the water of boiled crude drug 5 times, continue to decoct 20-30 minute (preferably: continue to decoct 22-28 minute; Be more preferably: continue decoction 25 minutes), filter to get filtrate, merge twice gained filtrate;
(5) pulverized by made to step (1) (2) crude drug, be added in step (4) gained filtrate, heating is concentrated into the half of original volume, obtains decoction.
8. a kind of preparation method for the treatment of the Chinese medicine composition decoction of early stage liver cirrhosis as claimed in claim 7, is characterized in that, the little fire of step (3) transfer decoct 30-40 minute (preferred: to turn little fire and decoct 32-38 minute; Be more preferably: turn little fire and decoct 35 minutes).
9. a kind of Chinese medicine composition for the treatment of early stage liver cirrhosis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable honeyed pill, its preparation method is:
(1) get Fructus Citri Sarcodactylis and Fructus Rubi removing impurity, be placed in steamer, Steam by water bath 25-35 minute (preferred: Steam by water bath 30 minutes), takes out, adds Mel and mix thoroughly, put into pot, explodes and turns yellow to surface, drain oil, cool with deep fat;
(2) get Polyporus and Poria, add meter Shui and run through, cut into slices, put into boiling container, steam 15-35 minute (preferably: 20-30 minute is steamed in vinegar fumersion with vinegar fumersion; Be more preferably: vinegar fumersion steams 25 minutes), taking-up, drying;
(3) by Fructus Gardeniae, Ramulus Cinnamomi, Radix Paeoniae Rubra, Radix Bupleuri, Radix Curcumae, Radix Angelicae Sinensis, Rhizoma Atractylodis and Radix Sophorae Flavescentis, the clear water adding boiled crude drug weight 6 times after rinse soaks 15 minutes, big fire is heated to boiling, continue 10 minutes, add Flos Rosae Davuricae and Cacumen Securinegae Suffruticosae again, turn little fire and decoct 30-50 minute (preferably: little fire decocts 35-45 minute; Be more preferably: turn little fire and decoct 40 minutes), filter, obtain filtrate;
(4) heat concentration step (3) gained filtrate to clear paste, pulverized by made to step (1) (2) crude drug, mix homogeneously with clear paste, add adjuvant refined honey, make plasticity agglomerate, rubbing, segmentation, round, drying, packaging, obtain honeyed pill.
10. a kind of preparation method for the treatment of the Chinese medicine composition honeyed pill of early stage liver cirrhosis as claimed in claim 9, it is characterized in that, the amount adding adjuvant refined honey in step (4) is the 0.5-0.7 of clear paste weight doubly (preferred: the amount adding adjuvant refined honey is 0.6 times of clear paste weight).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510084448.0A CN104587416A (en) | 2015-02-17 | 2015-02-17 | Traditional Chinese medicinal composition for treating early hepatocirrhosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510084448.0A CN104587416A (en) | 2015-02-17 | 2015-02-17 | Traditional Chinese medicinal composition for treating early hepatocirrhosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104587416A true CN104587416A (en) | 2015-05-06 |
Family
ID=53113687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510084448.0A Pending CN104587416A (en) | 2015-02-17 | 2015-02-17 | Traditional Chinese medicinal composition for treating early hepatocirrhosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104587416A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873817A (en) * | 2015-06-01 | 2015-09-02 | 朱绪臻 | Early liver cirrhosis treatment medicine |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369307A (en) * | 2002-02-07 | 2002-09-18 | 应天明 | Composite Chinese medicine for treating heptic fibrosis and cirrhosis due to hepatitis B and its mfg. method |
| CN101757544A (en) * | 2008-12-24 | 2010-06-30 | 天津市中宝制药有限公司 | Traditional Chinese medicine composition for treating hepatic fibrosis after hepatitis treatment |
| KR101402058B1 (en) * | 2012-08-03 | 2014-06-02 | 한국식품연구원 | Composition comprising extract of fermented Curcuma longa by natural fermented soybean and curcuminoid derivatives isolated therefrom for treating or preventing liver disease |
-
2015
- 2015-02-17 CN CN201510084448.0A patent/CN104587416A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369307A (en) * | 2002-02-07 | 2002-09-18 | 应天明 | Composite Chinese medicine for treating heptic fibrosis and cirrhosis due to hepatitis B and its mfg. method |
| CN101757544A (en) * | 2008-12-24 | 2010-06-30 | 天津市中宝制药有限公司 | Traditional Chinese medicine composition for treating hepatic fibrosis after hepatitis treatment |
| KR101402058B1 (en) * | 2012-08-03 | 2014-06-02 | 한국식품연구원 | Composition comprising extract of fermented Curcuma longa by natural fermented soybean and curcuminoid derivatives isolated therefrom for treating or preventing liver disease |
Non-Patent Citations (6)
| Title |
|---|
| 南京中医药大学: "《中药大辞典》", 31 March 2006 * |
| 庞玉新等: "《海南岛天然抗癌本草图鉴 第1卷》", 31 January 2009 * |
| 康武宏: "加味胃苓汤治疗肝炎后肝硬化腹水临床观察", 《现代中西医结合杂志》 * |
| 李东风: "中西医结合治疗肝硬化腹水疗效观察", 《实用中医药杂志》 * |
| 王彦刚等: "调肝方治疗肝硬化38例", 《陕西中医》 * |
| 纪戊霖: "《对症养生茶饮》", 30 June 2014 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873817A (en) * | 2015-06-01 | 2015-09-02 | 朱绪臻 | Early liver cirrhosis treatment medicine |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102488850B (en) | Traditional Chinese medicinal composition for treating alcoholic fatty liver and preparation method thereof | |
| CN104491759A (en) | Traditional Chinese medicine composition for treating cephalagra and preparation method thereof | |
| CN103816479B (en) | A kind of Chinese medicine composition for the treatment of chronic renal failure | |
| CN103055285B (en) | Traditional Chinese medicine for treating forepart hepetocirrhosis and preparation method thereof | |
| CN102000313B (en) | Medicament for treating rheumatic arthritis and preparation method thereof | |
| CN105126043A (en) | Traditional Chinese medicine composition for treating liver cirrhosis and application thereof | |
| CN105106872A (en) | Traditional Chinese medicine composition for treating coronary heart diseases and preparation method of traditional Chinese medicine composition | |
| CN104922538A (en) | Chinese herbal preparation used for IgA nephropathy and preparing method thereof | |
| CN104689279A (en) | Traditional Chinese medicine preparation for adenomyosis of uterus and preparation method thereof | |
| CN104547748A (en) | Anti-acne drug and preparation method thereof | |
| CN101204494B (en) | Medicine for chronic enteritis | |
| CN104587416A (en) | Traditional Chinese medicinal composition for treating early hepatocirrhosis | |
| CN103006809B (en) | Traditional Chinese medicine decoction for treating systemic lupus erythematosus | |
| CN105327181A (en) | Medicine composition for treating diabetes | |
| CN110193076A (en) | A kind of Chinese medicine composition and preparation for treating hypertension, hyperlipidemia, high blood viscosity | |
| CN104840891A (en) | Traditional Chinese medicine preparation used for treating alcoholic cardiomyopathy and preparation method thereof | |
| CN104547941A (en) | Traditional Chinese medicine composition for preventing and treating cerebral thrombosis | |
| CN104547875A (en) | Traditional Chinese medicine for treating arteries and veins stasis type chest stuffiness and pain | |
| CN103285360B (en) | Traditional Chinese medicinal preparation for treating thromboangiitis obliterans, and preparation method thereof | |
| CN107233528A (en) | It is a kind of effectively to treat endo-medicine of fatty liver and preparation method thereof | |
| CN104940726A (en) | Traditional Chinese medicine preparation for pulmonary alveolar proteinosis and preparation method of traditional Chinese medicine preparation | |
| CN104784649A (en) | Traditional Chinese medicine decoction for treating scapulohumeral periarthritis | |
| CN103520403B (en) | Traditional Chinese medicine for treating type II diabetes | |
| CN104873854A (en) | Traditional Chinese medicine preparation for rteriolar nephrosclerosis and preparation method thereof | |
| CN104922595A (en) | Traditional Chinese medicinal preparation for herpes zoster and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: Hami City Plaza, 839000 Xinjiang Road, Hami District No. 5 of silver district 1 building 2-301 Applicant after: Nie Wei Address before: Huayuan Road Licheng District of Ji'nan City, Shandong province 250000 No. 101 Applicant before: Nie Wei |
|
| COR | Change of bibliographic data | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150506 |