CN102488850B - Traditional Chinese medicinal composition for treating alcoholic fatty liver and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating alcoholic fatty liver and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating alcoholic fatty liver and a preparation method thereof. The traditional medicinal composition contains the following raw materials of: by weight, 15-35 parts of Artemisia capillaries, 15-30 parts of Radix Puerariae, 15-35 parts of Poria cocos, 10-25 parts of couchgrass root, 10-25 parts of Herba Eupatorii, 10-25 parts of cassia seed, 4-10 parts of green tea, 5-12 parts of haw, 5-12 parts of red sage root, 5-12 parts of sweet wormwood, 5-12 parts of cortex lycii, 8-15 parts of burdock, 4-10 parts of Caulis Bambusae In Taeniam, 4-10 parts of polygonatum rhizome, 4-10 parts of ligustrum lucidum, 4-10 parts of Ligusticum wallichii and 2-8 parts of licorice. The traditional Chinese medicinal composition can be made into any clinically acceptable oral medicinal preparation including pill, particulate agent, capsules or tablet and the like. It shows through clinical observation result that the traditional Chinese medicinal composition has substantial curative effects for alcoholic fatty liver. Safety observation indicates that the traditional Chinese medicinal composition is safe in clinic usage and has no toxic and side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of alcoholic fatty liver and preparation method thereof, belong to the treatment by Chinese herbs field of alcoholic fatty liver.
Background technology
Alcoholic fatty liver refers to surpass 5% of the wet quality of liver because taking in the excessive caused hepatocyte inner lipid accumulation of ethanol, and perhaps the upper per unit area of histology has the hepatocyte generation fat more than 1/3 to become.Compare with the other types fatty liver, the process of alcoholic fatty liver generation hepatic fibrosis and liver cirrhosis is relative very fast, and incidence rate is relatively high.According to estimates, approximately there are 1,500 ten thousand-2,000 ten thousand people excessive drinkings in the whole world, has 10%-20% that in various degree alcoholic liver disease is arranged in these people.Alcoholic liver disease in early days can be without any symptom, but this moment, pathological change occurred the liver interior tissue.Alcoholic liver disease mainly can be divided three classes, i.e. alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis.These three kinds of forms can separately or be mixed existence.
Chronic excessive drinking be modal fatty liver because of, long-term excessive drinking, can make hepatocyte that steatosis, necrosis and regeneration occur repeatedly by ethanol itself and its derivant acetaldehyde, and cause alcoholic liver disease, comprise alcoholic fatty liver, alcoholic hepatitis, hepatic fibrosis and liver cirrhosis.
Alcoholic fatty liver belongs to " wine is long-pending ", " hypochondriac pain ", " gathering (alcoholophilia) " and " liver addiction (painful abdominal mass) " category.Wine is damp and hot product, but the cold expelling of a small amount of drink is opened the stasis of blood, the collateral dredging that helps digestion, harmonizing yingfen and weifen; And long-term excessive drinking just forms damp and hot poisonous heresy, pents up middle Jiao, injures taste, connects and liver and gall, is stopped at the gastral cavity abdomen or hinders under the side of body.Wine contains damp and hot two property, can impairment of YANG also can impairment of YIN.The author thinks, wine is that a kind of special damp and hot poison is evil, heavy drinking, damp and hot accumulate to steam cause edema with the liver involved and lose and dredge, irritability stasis, incoordination between the liver and stomach, with the passing of time blood-vessel obstructive, the turbid interior life of expectorant, be stopped under the side of body and form primary disease,
The clinical manifestation of alcoholic fatty liver is directly proportional to the degree of fatty infiltration of liver, and after excess fat is removed in liver, symptom can disappear.Clinically with hepatomegaly for the most common sign, secondly be pain in the hepatic region and tenderness.A few patients can have slight jaundice, and the lab testing prompting is blocked relevant with biliary system.The patient with severe symptoms can have ascites and lower limbs edema, accidental splenomegaly.Some patients were can show with vitamin deficiency, as peripheral neuritis, glossitis, angular cheilitis, the dermal ecchymosis etc.
Most patients' alcoholic fatty liver is completely reversibility, and generally after alleviating alcohol addiction, fatty liver fades away.If but long-term excessive drinking can make hepatocyte that steatosis, necrosis occur repeatedly, finally develops into alcoholic hepatitis and alcoholic cirrhosis, severe patient jeopardizes people's life.The fatty liver people can die suddenly once in a while, and this is the result of multiple encephalopathy and pulmonary fat embolism.
Mostly there is slow, the defect such as curative effect is remarkable not that takes effect in the existing Chinese patent medicine that is used for the treatment of the alcoholic liver fatty liver, and haves much room for improvement.
Summary of the invention
Technical problem to be solved by this invention is to overcome the deficiencies in the prior art, and the Chinese medicine composition of a kind of instant effect, the treatment alcoholic fatty liver that evident in efficacy, safety is good is provided.
Technical problem to be solved by this invention is achieved through the following technical solutions:
A kind of Chinese medicine composition for the treatment of alcoholic fatty liver comprises that each crude drug of following weight portion is made:
Herba Artemisiae Scopariae 15-35 part, Radix Puerariae 15-30 part, Poria 15-35 part, Rhizoma Imperatae 10-25 part, Herba Eupatorii 10-25 part, Semen Cassiae 10-25 part, green tea 4-10 part, Fructus Crataegi 5-12 part, Radix Salviae Miltiorrhizae 5-12 part, Herba Artemisiae Annuae 5-12 part, Cortex Lycii 5-12 part, Fructus Arctii 8-15 part, Caulis Bambusae In Taenia 4-10 part, Rhizoma Polygonati 4-10 part, Fructus Ligustri Lucidi 4-10 part, Rhizoma Chuanxiong 4-10 part and Radix Glycyrrhizae 2-8 part.
Preferably, the parts by weight of each crude drug is:
30 parts of Herba Artemisiae Scopariae, 25 parts of Radix Puerariaes, 30 parts, Poria, 20 parts of Rhizoma Imperataes, 20 parts of Herba Eupatoriis, 20 parts of Semen Cassiaes, 8 parts of green tea, 10 parts of Fructus Crataegis, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Herba Artemisiae Annuaes, 10 parts of Cortex Lycii, 12 parts of Fructus Arctiis, 8 parts of Caulis Bambusae In Taenia, 8 parts of Rhizoma Polygonatis, 8 parts of Fructus Ligustri Lucidi, 8 parts of Rhizoma Chuanxiongs, 4 parts, Radix Glycyrrhizae.
It is heavy drinking to the cause of disease of alcoholic fatty liver that Chinese medicine composition of the present invention is based on the inventor, damp and hot accumulate to steam cause edema with the liver involved and lose and dredge, irritability stasis, incoordination between the liver and stomach, with the passing of time blood-vessel obstructive, the turbid interior life of expectorant, be stopped under the side of body and form primary disease, take alcoholic intoxication as first, hold concurrently and lead to stagnant as the rule for the treatment of take soothing the liver purging heat with blood stasis dispelling, simultaneously according to inventor clinical experience and pharmaceutical research achievement for many years, the crude drug of the calming liver and clearing heat that filters out, QI invigorating stomach reinforcing, blood fat reducing antiviral, heat-clearing and toxic substances removing, replenishing blood and nourishing liver, according to certain weight proportion prescription, be prepared from.
Herba Artemisiae Scopariae: be the seedling of feverfew Herba Artemisiae Scopariae Artemisia capillaris Thunb..Formal name used at school: Artemisia scoparia Waldst.et Kit. Herba Artemisiae Scopariae is not dead through the winter, and old of Chun Zeyin and giving birth to is therefore named because of old or Herba Artemisiae Scopariae.The nature and flavor cold nature, acrid in the mouth, hardship.Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.Be used for jaundice oliguria, eczema pruritus, infectious jaundice type hepatitis.Pharmaceutical research has function of gallbladder promoting, and liver function protecting is analgesic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating.
Radix Puerariae: property is sweet, hot, flat, nontoxic, cures mainly: quench one's thirst, high fever of the body, vomiting, all frauds, play cloudy gas, separate all poison.
Poria: nature and flavor: sweet, light, flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness.Cure mainly: dysuria; The edema distension; The phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; The seminal emission nebulousurine.
Rhizoma Imperatae: be the rhizome of grass perennial herb Herba Imperatae.Sweet-bitter flavor, cold in nature, nontoxic.Enter lung meridian, stomach warp, small intestine meridian.Function: cooling blood for hemostasis, heat-clearing and toxic substances removing.Cure mainly: be used for to spit blood, hematuria, pyretic stranguria, edema, jaundice, dysuria, calentura excessive thirst, the gastric heat sound of vomiting of vomitting, cough.
Herba Eupatorii: the aerial parts of feverfew Herba Eupatorii (Herba Chlorophyti) Eupatorium fortunei Turcz. has another name called Radix Crotonis Crassifolii, water perfume.With all herbal medicine.The effect of analgesic clearing away summer-heat, dispelling dampness to invigorate the stomach, preventing or arresting vomiting is arranged.The property hot, flat.Return spleen, stomach, lung meridian.Effect: expelling summer-heat and damp, ward off dirty and in.Cure mainly and experience heat-damp in summer; The cold and heat headache; Accumulate in moistening; The gastral cavity painful abdominal mass is not hungry; Nausea and vomiting; Sweet greasy in mouthful.
Semen Cassiae: property is sweet, and is bitter, salty, be slightly cold.Return liver, large intestine channel.Has clearing away heat to improve acuity of vision, the effect of loosening bowel to relieve constipation.Be used for the puckery pain of conjunctival congestion, the many tears of photophobia, have a headache dizzy, poor vision, constipation.
Fructus Crataegi: acid is sweet, tepor.Enter spleen, stomach, Liver Channel.Function cures mainly: helps digestion long-pending, and dissipating blood stasis blood, expelling tenia.Promoting digestion and invigorating the stomach, the circulation of qi promoting dissipating blood stasis.Be used for meat stagnation, stomach alkane distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipidemia.
Radix Salviae Miltiorrhizae: property is bitter, is slightly cold.GUIXIN, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.Cure mainly menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Herba Artemisiae Annuae: be the dry aerial parts of feverfew Herba Artemisiae Annuae Artemisia ann ua L..Clearing away summer-heat, except steaming, preventing the attack (or recurrence) of malaria.Be used for the pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.Clear deficiency-heat thoroughly, removing heat from blood, except steaming, removes and steams, preventing the attack (or recurrence) of malaria.Be used for the pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.
Cortex Lycii: be the root bark of eggplant kind of plant Fructus Lycii etc.Function cures mainly: heat clearing away, removing heat from blood.Control asthenia hectic fever night sweat, the lung-heat cough with asthma, spit blood, epistaxis, and stranguria with blood, quench one's thirst, hypertension, carbuncle, malignant boil.
Fructus Arctii: property is hot, and hardship is cold.Enter meridian of Hand-TAI YIN.Function cures mainly: the heat of dispeling the wind, detumescence poison.Control the pathogenic wind toxic swelling of the face, dizziness, throat heat is swollen, toothache, cough, quench one's thirst, carbuncle skin ulcer scabies.
Caulis Bambusae In Taenia: the dry intermediate layer that is the stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.Property is sweet, is slightly cold.Enter lung, stomach, gallbladder meridian.Effect: clearing away heat to stop vomiting, clearing away phlegm dissipating depression of QI.
Rhizoma Polygonati: be the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati (Polygonatum kingianum Coll.et Hemsl.), Rhizoma Polygonati (Polygonatum sibiricum Red.) or Polygonatum cyrtonema Hua (Polygonatum cyrtonema Hua.).Has boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, the interior-heat disease such as quench one's thirst.
Fructus Ligustri Lucidi: the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi.Sweet in the mouth, hardship, cool in nature.Return liver, kidney channel.Effect: the tonifying liver kidney yin, crow must improving eyesight.Cure mainly: be used for the hepatic and renal YIN deficiency, soreness of waist tinnitus, early whitening of beard and hair; Unseeing, poor vision; Fever due to yin deficiency, gastropathy and gout and hyperuricemia.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Function with cure mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for pacifying nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Radix Glycyrrhizae: Radix Glycyrrhizae: property is sweet, and is flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
In order to reach better therapeutic effect, when the patient has the hyperactivity of fire caused by deficiency of YIN pattern of syndrome, can add the crude drug of following weight parts in above-mentioned Chinese medicine composition: Herba Dendrobii 8-15 part, Radix Scutellariae 8-15 part, Cornu Saigae Tataricae 3-8 part, Cortex Moutan 6-12 part, Radix Gentianae 6-12 part, Flos Chrysanthemi 5-10 part, Fructus Gardeniae 5-10 part, Aloe 5-10 part; Preferably, the weight portion of each crude drug is: 12 parts of Herba Dendrobii, 12 parts of Radix Scutellariaes, 5 parts of Cornu Saigae Tataricae, 10 parts of Cortex Moutans, 10 parts of Radix Gentianaes, 8 parts of Flos Chrysanthemis, 8 parts of Fructus Gardeniaes, 8 parts of Aloes.
Herba Dendrobii: another name: Herba Dendrobii, Shi Lan, bracketplant, Dendrobium nobile, maple bean.Cold nature, sweet; Return stomach, kidney channel; Function cures mainly: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Be used for cloudy impairment of body fluid and lose, the xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.
Cornu Saigae Tataricae: property is salty, cold.Function: clearing away heat and relieving spasm, suppressing the hyperactive liver to relieve the wind syndrome, removing toxic substances and promoting subsidence of swelling.Cure mainly that unconsciousness due to high fever, delirium are gone mad, the diseases such as infantile convulsion is twitched, conjunctival congestion and swelling pain.
Cortex Moutan: cold in nature, bitter in the mouth; Cool; Be slightly cold.GUIXIN; Liver; Kidney; Lung meridian.Effect: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; The rheumatism pyretic arthralgia.
Radix Gentianae: be root and the rhizome of gentianaceae plant Radix Gentianae, bar leaf Radix Gentianae, three flower Radix Gentianae and Yunnan Radix Gentianae.Effect with heat clearing away, eliminating pathogen in the liver, arresting convulsion.The Compendium of Material Medica record: " nature and flavor are bitter, and are puckery, Great Cold, nontoxic.Cure mainly cold and heat between bone, frightened pathogenic factor gas, the wound absolutely that continues, determine the five internal organs, the parasite killing poison.
When the patient has wet Sheng pattern of syndrome, can add the crude drug of following weight parts in above-mentioned Chinese medicine composition: Polyporus 8-15 part, Rhizoma Alismatis 6-12 part, Cortex Phellodendri 6-12 part, Herba Lysimachiae 5-10 part, Herba Lobeliae Chinensis 5-10 part, Semen Plantaginis 5-10 part and Medulla Tetrapanacis 4-8 part; Preferably, the weight portion of each crude drug is: 12 parts of Polyporus, 10 parts of Rhizoma Alismatis, 10 parts of Cortex Phellodendris, 8 parts of Herba Lysimachiaes, 8 parts of Herba Lobeliae Chinensis, 8 parts of Semen Plantaginiss, 6 parts of Medulla Tetrapanaciss.
Polyporus: sweet in the mouth, light, flat, return kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen.Control dysuria, edema, have loose bowels, stranguria with turbid discharge, leukorrhagia.
Cortex Phellodendri: be the dry bark of rutaceae wampee or Cortex Phellodendri.The former practises title " Cortex Phellodendri ", and the latter practises title " Cortex Phellodendri ".The nature and flavor bitter cold, have heat clearing and damp drying, and pathogenic fire purging is except steaming, the effect of detoxification sore treatment.
Herba Lysimachiae: be Ofthe Primulaceae Lysimachia christinae Hance (formal name used at school: dry herb Lysimachia christinaeHance).All there is distribution each province, the south of the River.Summer, Qiu Erji gather.Remove impurity, dry, cutting is given birth to and is used.Have heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, the effect of dampness removing jaundice eliminating, can be used for pyretic stranguria, and husky the pouring urinated and puckeryly had a pain, jaundice dark coloured urine, carbuncle furuncle, venom, liver and bile stone, the diseases such as lithangiuria.
Herba Lobeliae Chinensis: have another name called anxious separate that rope, half ray flower, Herba Lobeliae Chinensis, edible kernel of melon seeds grass, snake are careless, Herba Hedyotidis Diffusae etc., for the perennial herblet of campanulaceae, all herbal medicine, possess inducing diuresis to remove edema, the effects such as heat-clearing and toxic substances removing, can be used for treating extensive abdominal edema, face foot edema, carbuncle furuncle, snake bite and insect sting etc.
Semen Plantaginis: have another name called Herba Plantaginis reality, Rana limnocharis clothing, pig ear tassel, phoenix eyes Semen Plantaginis, this product is the dry mature seed of Plantaginaceae plant Herba Plantaginis.Be all wild.The fruit ear of gathering during seed maturity in summer, two season of autumn, dry, and rubs seed, removes impurity.Main product in Heilungkiang, the ground such as Liaoning, Hebei.Former plant is born in hill, roadside, flower nursery or vegetable garden.Happiness warm and moist weather, cold-resistant, all can grow in the level land, mountain area, to soil, requires not tight.This product is sweet in flavor and cold in property, enters kidney, bladder, liver, lung meridian, function relieving stranguria by diuresis, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, removing heat-phlegm.
Medulla Tetrapanacis: another name: the bandit takes off, from south, the Tuo that lives, lean on that business, rice-paper plant, Herba Alii fistulosi grass, white Medulla Tetrapanacis, logical flower, flowers and plants, MEDULLA TETRAPANACIS, Semen Sterculiae Lychnophorae, bubble are logical, slender acanthopanax wind, wide intestinal, Da Tongta, clematis biondiana Pavolini, five jiaos of Cortex Acanthopanacis Radicis, logical slender acanthopanax, the Da Ye Cortex Acanthopancis spent.Cure mainly: hygropyrexia dark coloured urine, the puckery pain of gonorrhea, edema oliguria, agalactia etc.
When patient's liver pain, can add the crude drug of following weight parts in above-mentioned Chinese medicine composition: Radix Angelicae Sinensis 6-12 part, Rhizoma Cyperi 8-15 part, Rhizoma Corydalis 8-15 part, Radix Aucklandiae 6-12 part, Radix Curcumae 5-10 part, Fructus Aurantii 5-10 part, Fructus Toosendan 5-10 part and Retinervus Luffae Fructus 3-8 part; Preferably, the weight portion of each crude drug is: 9 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Cyperis, 12 parts of Rhizoma Corydalis, 9 parts of the Radix Aucklandiae, 8 parts of Radix Curcumaes, 8 parts of Fructus Aurantiis, 8 parts of Fructus Toosendans, 5 parts of Retinervus Luffae Fructuss.
Rhizoma Cyperi: the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.
Rhizoma Corydalis: have another name called Rhizoma Corydalis, Rhizoma Corydalis, be Papaveraceae Corydalis herbaceos perennial,, with the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae, Bulbus Fritillariae Uninbracteatae etc. and title " Zhejiang eight flavors ", be large conventional Chinese medicine.The Rhizoma Corydalis history is stated from " Kaibao Bencao ", and is warm in nature, and acrid in the mouth is bitter, enters the heart, spleen, liver, lung, is the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, especially with the effect of pain relieving, is world-famous for.Li Shizhen (1518-1593 A.D.) is concluded Rhizoma Corydalis in Compendium of Material Medica have " invigorating blood circulation, promoting the circulation of QI, pain relieving, diuresis " four large effects.
Fructus Toosendan: be again Fructus Toosendan, the property of medicine is cold, bitter in the mouth.Effect is promoting the circulation of QI to relieve pain, soothing the liver purging heat, and parasite killing is treated tinea.Cure mainly the side of body costalgia that pathogenic fire derived from stagnation of liver-QI produces.
Retinervus Luffae Fructus: the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Summer, two season of autumn fruit maturation, peel flavescence, innerly pluck when withered, remove crust and sarcocarp, clean, dry, remove seed.The property sweet, flat.Return lung, stomach, Liver Channel.Function cures mainly: collateral dredging, invigorate blood circulation, and dispel the wind.Be used for the arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis.
When patient's food is received, can add the crude drug of following weight parts in order to reach better therapeutic effect in above-mentioned Chinese medicine composition: Rhizoma Dioscoreae 6-12 part, Fructus Setariae Germinatus 6-12 part, Fructus Hordei Germinatus 6-12 part, Massa Medicata Fermentata 8-15 part, Fructus Amomi 8-15 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Radix Ginseng 4-8 part and Pericarpium Citri Reticulatae 4-8 part; Preferably, the weight portion of each crude drug is: 9 parts of Rhizoma Dioscoreaes, 9 parts of Fructus Setariae Germinatuss, 9 parts, Fructus Hordei Germinatus, 12 parts of Massa Medicata Fermentata, 12 parts of Fructus Amomis, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Radix Ginsengs, 6 parts of Pericarpium Citri Reticulataes.
Massa Medicata Fermentata: by the herbal leaven that the mixing after fermentation such as flour, wheat bran obtain, warm in nature, Gan Xinzhi retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis stomachache, children's's enlarged abdomen is hard long-pending.
The present invention treats take alcoholic intoxication as first, hold concurrently and lead to stagnant with soothing the liver purging heat with blood stasis dispelling, filter out the crude drug of calming liver and clearing heat, QI invigorating stomach reinforcing, blood fat reducing antiviral, heat-clearing and toxic substances removing, replenishing blood and nourishing liver, all medicines share, and play altogether detoxification and promoting urination, soothing the liverly purge heat, blood stasis dispelling is logical stagnant and change the merit of turbid blood fat reducing.The principles of formulating prescriptions of Chinese medicine composition of the present invention had both met the principle of differentiation of tcm, the pathogenesis of the alcoholic fatty liver that hits again.Clinical observation on the therapeutic effect is tested and is shown, can effectively improve clinical symptoms, sign and the blood lipid level of alcoholic fatty liver on Chinese medicine composition of the present invention, evident in efficacy, clinical observation has no Chinese medicine composition of the present invention any toxic and side effects.
The specification of the crude drug of respectively distinguishing the flavor of that the present invention is used all meets national medical standard, can buy and obtain at pharmacy.
Chinese medicine composition of the present invention can be prepared into any acceptable oral formulations clinically by this area conventional formulation method; Described oral formulations includes but not limited to tablet, capsule, granule, powder, pill, oral liquid, syrup or drop pill etc.
A kind of preparation method of Chinese medicine composition of the present invention: after each crude drug of the present invention is taken by described weight portion proportioning, pulverize, sieve (can be for example the 400-1000 mesh sieve), obtain.Certainly, after also each crude drug can being pulverized, add the required adjuvant of preparations shaping or excipient, according to conventional method, be prepared into capsule, tablet or pill.
Preferably, a kind of method for preparing above-mentioned Chinese medicine composition comprises the following steps:
(1) take each crude drug by described weight proportion;
(2) get each crude drug and decoct with water, decoction liquor filters, and merging filtrate, be condensed into thick paste, and drying obtains dry extract, and is standby;
(3), with dry extract and the pharmaceutical preparation auxiliary materials and mixing of step (2) gained, make the preparation semi-finished product, then through preparations shaping technique, make the preparation finished product.
Preferably, in step (2), each crude drug is decocted with water 2 times, the decocting that wherein adds 3-8 times of weight for the 1st time boils 1-2.5 hour, and the decocting that adds 3-5 times of weight for the 2nd time boils 1-2.5 hour;
While preferably, in step (2), filtrate being condensed into 55 ℃ of mensuration, relative density is 1.06～1.10 thick paste;
Drying described in step (2) can be spray drying, lyophilization or vacuum drying, is preferably spray drying.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factors such as concrete dosage form, patient's age, health status.As guidance: for capsule, oral: calculate with contained crude drug amount in Chinese medicine composition, 3 times on the one, each 2.7g 5.4g.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.But these embodiment are only exemplary, scope of the present invention are not formed any restriction.It will be understood by those skilled in the art that lower without departing from the spirit and scope of the present invention and can modify or replace details and the form of technical solution of the present invention, but these modifications and replacement all fall within the scope of protection of the present invention.
The preparation of embodiment 1 capsule
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 30, Radix Puerariae 25, Poria 30, Rhizoma Imperatae 20, Herba Eupatorii 20, Semen Cassiae 20, green tea 8, Fructus Crataegi 10, Radix Salviae Miltiorrhizae 10, Herba Artemisiae Annuae 10, Cortex Lycii 10, Fructus Arctii 12, Caulis Bambusae In Taenia 8, Rhizoma Polygonati 8, Fructus Ligustri Lucidi 8, Rhizoma Chuanxiong 8 and Radix Glycyrrhizae 4.
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 2 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 15, Radix Puerariae 15, Poria 15, Rhizoma Imperatae 10, Herba Eupatorii 10, Semen Cassiae 10, green tea 4, Fructus Crataegi 5, Radix Salviae Miltiorrhizae 5, Herba Artemisiae Annuae 5, Cortex Lycii 5, Fructus Arctii 8, Caulis Bambusae In Taenia 4, Rhizoma Polygonati 4, Fructus Ligustri Lucidi 4, Rhizoma Chuanxiong 4 and Radix Glycyrrhizae 2.
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 3 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 35, Radix Puerariae 30, Poria 35, Rhizoma Imperatae 25, Herba Eupatorii 25, Semen Cassiae 25, green tea 10, Fructus Crataegi 12, Radix Salviae Miltiorrhizae 12, Herba Artemisiae Annuae 12, Cortex Lycii 12, Fructus Arctii 15, Caulis Bambusae In Taenia 10, Rhizoma Polygonati 10, Fructus Ligustri Lucidi 10, Rhizoma Chuanxiong 10, Radix Glycyrrhizae 8.
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 4 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 30, Radix Puerariae 25, Poria 30, Rhizoma Imperatae 20, Herba Eupatorii 20, Semen Cassiae 20, green tea 8, Fructus Crataegi 10, Radix Salviae Miltiorrhizae 10, Herba Artemisiae Annuae 10, Cortex Lycii 10, Fructus Arctii 12, Caulis Bambusae In Taenia 8, Rhizoma Polygonati 8, Fructus Ligustri Lucidi 8, Rhizoma Chuanxiong 8, Radix Glycyrrhizae 4, Herba Dendrobii 12, Radix Scutellariae 12, Cornu Saigae Tataricae 5, Cortex Moutan 10, Radix Gentianae 10, Flos Chrysanthemi 8, Fructus Gardeniae 8, Aloe 8.
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 5 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 15, Radix Puerariae 15, Poria 15, Rhizoma Imperatae 10, Herba Eupatorii 10, Semen Cassiae 10, green tea 4, Fructus Crataegi 5, Radix Salviae Miltiorrhizae 5, Herba Artemisiae Annuae 5, Cortex Lycii 5, Fructus Arctii 8, Caulis Bambusae In Taenia 4, Rhizoma Polygonati 4, Fructus Ligustri Lucidi 4, Rhizoma Chuanxiong 4, Radix Glycyrrhizae 2, Herba Dendrobii 8, Radix Scutellariae 8, Cornu Saigae Tataricae 3, Cortex Moutan 6, Radix Gentianae 6, Flos Chrysanthemi 5, Fructus Gardeniae 5 and Aloe 5.
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 6 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 35, Radix Puerariae 30, Poria 35, Rhizoma Imperatae 25, Herba Eupatorii 25, Semen Cassiae 25, green tea 10, Fructus Crataegi 12, Radix Salviae Miltiorrhizae 12, Herba Artemisiae Annuae 12, Cortex Lycii 12, Fructus Arctii 15, Caulis Bambusae In Taenia 10, Rhizoma Polygonati 10, Fructus Ligustri Lucidi 10, Rhizoma Chuanxiong 10, Radix Glycyrrhizae 8, Herba Dendrobii 15, Radix Scutellariae 15, Cornu Saigae Tataricae 8, Cortex Moutan 12, Radix Gentianae 12, Flos Chrysanthemi 10, Fructus Gardeniae 10, Aloe 10;
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 7 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 30, Radix Puerariae 25, Poria 30, Rhizoma Imperatae 20, Herba Eupatorii 20, Semen Cassiae 20, green tea 8, Fructus Crataegi 10, Radix Salviae Miltiorrhizae 10, Herba Artemisiae Annuae 10, Cortex Lycii 10, Fructus Arctii 12, Caulis Bambusae In Taenia 8, Rhizoma Polygonati 8, Fructus Ligustri Lucidi 8, Rhizoma Chuanxiong 8, Radix Glycyrrhizae 4, Polyporus 12, Rhizoma Alismatis 10, Cortex Phellodendri 10, Herba Lysimachiae 8, Herba Lobeliae Chinensis 8, Semen Plantaginis 8, Medulla Tetrapanacis 6;
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 8 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 15, Radix Puerariae 15, Poria 15, Rhizoma Imperatae 10, Herba Eupatorii 10, Semen Cassiae 10, green tea 4, Fructus Crataegi 5, Radix Salviae Miltiorrhizae 5, Herba Artemisiae Annuae 5, Cortex Lycii 5, Fructus Arctii 8, Caulis Bambusae In Taenia 4, Rhizoma Polygonati 4, Fructus Ligustri Lucidi 4, Rhizoma Chuanxiong 4, Radix Glycyrrhizae 2, Polyporus 8, Rhizoma Alismatis 6, Cortex Phellodendri 6, Herba Lysimachiae 5, Herba Lobeliae Chinensis 5, Semen Plantaginis 5 and Medulla Tetrapanacis 4.
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 9 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 35, Radix Puerariae 30, Poria 35, Rhizoma Imperatae 25, Herba Eupatorii 25, Semen Cassiae 25, green tea 10, Fructus Crataegi 12, Radix Salviae Miltiorrhizae 12, Herba Artemisiae Annuae 12, Cortex Lycii 12, Fructus Arctii 15, Caulis Bambusae In Taenia 10, Rhizoma Polygonati 10, Fructus Ligustri Lucidi 10, Rhizoma Chuanxiong 10, Radix Glycyrrhizae 8, Polyporus 15, Rhizoma Alismatis 12, Cortex Phellodendri 12, Herba Lysimachiae 10, Herba Lobeliae Chinensis 10, Semen Plantaginis 10 and Medulla Tetrapanacis 8.
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 10 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 30, Radix Puerariae 25, Poria 30, Rhizoma Imperatae 20, Herba Eupatorii 20, Semen Cassiae 20, green tea 8, Fructus Crataegi 10, Radix Salviae Miltiorrhizae 10, Herba Artemisiae Annuae 10, Cortex Lycii 10, Fructus Arctii 12, Caulis Bambusae In Taenia 8, Rhizoma Polygonati 8, Fructus Ligustri Lucidi 8, Rhizoma Chuanxiong 8, Radix Glycyrrhizae 4, Radix Angelicae Sinensis 9, Rhizoma Cyperi 12, Rhizoma Corydalis 12, the Radix Aucklandiae 9, Radix Curcumae 8, Fructus Aurantii 8, Fructus Toosendan 8, Retinervus Luffae Fructus 5;
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 11 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 15, Radix Puerariae 15, Poria 15, Rhizoma Imperatae 10, Herba Eupatorii 10, Semen Cassiae 10, green tea 4, Fructus Crataegi 5, Radix Salviae Miltiorrhizae 5, Herba Artemisiae Annuae 5, Cortex Lycii 5, Fructus Arctii 8, Caulis Bambusae In Taenia 4, Rhizoma Polygonati 4, Fructus Ligustri Lucidi 4, Rhizoma Chuanxiong 4, Radix Glycyrrhizae 2, Radix Angelicae Sinensis 6, Rhizoma Cyperi 8, Rhizoma Corydalis 8, the Radix Aucklandiae 6, Radix Curcumae 5, Fructus Aurantii 5, Fructus Toosendan 5 and Retinervus Luffae Fructus 3;
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 12 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 35, Radix Puerariae 30, Poria 35, Rhizoma Imperatae 25, Herba Eupatorii 25, Semen Cassiae 25, green tea 10, Fructus Crataegi 12, Radix Salviae Miltiorrhizae 12, Herba Artemisiae Annuae 12, Cortex Lycii 12, Fructus Arctii 15, Caulis Bambusae In Taenia 10, Rhizoma Polygonati 10, Fructus Ligustri Lucidi 10, Rhizoma Chuanxiong 10, Radix Glycyrrhizae 8, Radix Angelicae Sinensis 12, Rhizoma Cyperi 15, Rhizoma Corydalis 15, the Radix Aucklandiae 12, Radix Curcumae 10, Fructus Aurantii 10, Fructus Toosendan 10 and Retinervus Luffae Fructus 8;
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 13 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 30, Radix Puerariae 25, Poria 30, Rhizoma Imperatae 20, Herba Eupatorii 20, Semen Cassiae 20, green tea 8, Fructus Crataegi 10, Radix Salviae Miltiorrhizae 10, Herba Artemisiae Annuae 10, Cortex Lycii 10, Fructus Arctii 12, Caulis Bambusae In Taenia 8, Rhizoma Polygonati 8, Fructus Ligustri Lucidi 8, Rhizoma Chuanxiong 8, Radix Glycyrrhizae 4, Rhizoma Dioscoreae 9, Fructus Setariae Germinatus 9, Fructus Hordei Germinatus 9, Massa Medicata Fermentata 12, Fructus Amomi 12, the Rhizoma Atractylodis Macrocephalae 8, Radix Ginseng 6 and Pericarpium Citri Reticulatae 6;
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 14 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 15, Radix Puerariae 15, Poria 15, Rhizoma Imperatae 10, Herba Eupatorii 10, Semen Cassiae 10, green tea 4, Fructus Crataegi 5, Radix Salviae Miltiorrhizae 5, Herba Artemisiae Annuae 5, Cortex Lycii 5, Fructus Arctii 8, Caulis Bambusae In Taenia 4, Rhizoma Polygonati 4, Fructus Ligustri Lucidi 4, Rhizoma Chuanxiong 4, Radix Glycyrrhizae 2, Rhizoma Dioscoreae 6, Fructus Setariae Germinatus 6, Fructus Hordei Germinatus 6, Massa Medicata Fermentata 8, Fructus Amomi 8, the Rhizoma Atractylodis Macrocephalae 5, Radix Ginseng 4 and Pericarpium Citri Reticulatae 4;
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The preparation of embodiment 15 capsules
(1) take clean medical material (unit: g): Herba Artemisiae Scopariae 35, Radix Puerariae 30, Poria 35, Rhizoma Imperatae 25, Herba Eupatorii 25, Semen Cassiae 25, green tea 10, Fructus Crataegi 12, Radix Salviae Miltiorrhizae 12, Herba Artemisiae Annuae 12, Cortex Lycii 12, Fructus Arctii 15, Caulis Bambusae In Taenia 10, Rhizoma Polygonati 10, Fructus Ligustri Lucidi 10, Rhizoma Chuanxiong 10, Radix Glycyrrhizae 8, Rhizoma Dioscoreae 12, Fructus Setariae Germinatus 12, Fructus Hordei Germinatus 12, Massa Medicata Fermentata 15, Fructus Amomi 15, the Rhizoma Atractylodis Macrocephalae 10, Radix Ginseng 8 and Pericarpium Citri Reticulatae 8;
(2) preparation of dry extract
After being mixed, above-mentioned each crude drug decocts with water twice, the decocting that adds for the first time 10 times of weight boiled 2.5 hours, the decocting that adds for the second time 8 times of weight boiled 1.5 hours, decoction liquor filters, merging filtrate, filtrate are concentrated into the thick paste that relative density is 1.06～1.10 (55 ℃), spray drying, obtain dry extract, standby;
(3) preparation of capsule
Get it filled material fine powder and dry extract, add appropriate lactose, mixes, and dry-pressing becomes granule, incapsulates, and obtains; Containing effective crude drug amount in every capsules is 1.33g.
The clinical observation on the therapeutic effect test of test example traditional Chinese medicine composition for treating alcoholic fatty liver of the present invention
One, clinical physical data
1.1 case is selected: all are observed case and all meet the alcoholic liver disease diagnostic criteria; The diagnostic criteria of alcoholic fatty liver: (1) has long-term heavy drinking history, drink every day amount to ethanol amount 〉=40g (women 〉=20g), continuous more than 5 years; Or within nearly 2 weeks every day drink and amount to ethanol amount 〉=80g person.(2) non-evident sympton or slight abdominal distention, anorexia are arranged, feel sick and dull pain in liver.(3) physical examination liver enlargement.(4) serum alanine aminotransferase (alanine aminotrans-ferase, ALT), aspartate aminotransferase (aspartate aminotransferase, AST) and gamma glutamyl transpeptidase (γ-glutamyl transpeptidase, γ-GT) raise, general in 5 times of Upper Limit of Normal Value, and with AST, increase and preponderate, AST/ALT＞2, be down to Upper Limit of Normal Value below 2 times after 4 weeks of alcohol prohibition.(5) light, the moderate swelling of ultrasound diagnosis liver, the high echo of near field, hepatic region diffusivity point-like, far field echo attenuation, luminous point is sparse, and the liver flexible innerduct structure shows unclear.(6) non-alcoholic fatty liver disease and viral infection and drug-induced hepatic injury except.(7) can strict abstainer after treatment starts.
1.2 physical data: observe case and be the outpatient of the hospital of traditional Chinese hospital, totally 225 examples, male 196 examples, female's 29 examples; 26～69 years old age, average 45.8 years old; The course of disease 3～12 years, average 6.8 years.225 routine patients are divided into 5 groups at random.Every group of 45 examples, compare the equal not statistically significant of difference for 5 groups at aspects such as sex, age and the courses of disease.
Two, Therapeutic Method
Test 1 group and adopt the prepared capsule treatment of embodiment 1-3, test 2 groups and adopt the prepared capsule treatment of embodiment 4-6; Test 3 groups and adopt the prepared capsule treatment of embodiment 7-9, test 4 groups and adopt the prepared capsule treatment of embodiment 10-12; Test 5 groups and adopt the prepared capsule treatment of embodiment 13-15; Oral, one time 8 (0.6g crude drug/grain), 3 times on the one, 30 days is a course for the treatment of, treats altogether 3 courses for the treatment of; All cases except strict alleviating alcohol addiction, advise it to note suitably having a rest and moderate exercise, the absorption that increases high-quality protein, heat, low fat and be rich in folic acid food.
Three, observational technique
Main observation clinical efficacy, Blood Lipid and untoward reaction.Observe weekly 1 sings and symptoms during treatment and change, every 3 weeks check 1 ALT, AST, γ-GT, TC, TG and liver B ultrasonic.Ultrasound diagnosis is divided into fatty liver level Four and scores respectively, normal (0 minute); Slightly (2 minutes): near field, hepatic region diffusivity echo is slightly increased and is increased slightly, and a little more than spleen and kidney, the liver interior conduit is owed clear person; Moderate (4 minutes): near field, hepatic region diffusivity Echoenhance and increase thick, higher than spleen and kidney person, the unclear person of liver flexible innerduct structure; Severe (6 minutes): near field, hepatic region diffusivity echo obviously strengthens and increases slightly, apparently higher than spleen and kidney person.
Three, efficacy assessment standard
Clinical cure: clinical symptom disappearance, liver function test ALT, AST and γ-GT full recovery is normal, and liver bounces back to normally, and it is normal that ultrasound diagnosis liver echo is recovered, or by severe, returned to slightly;
Effectively: clinical symptom relief, liver function, ultrasound diagnosis are improved;
Invalid: as not reach effective standard.
Four, observation of curative effect result
The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating alcoholic fatty liver of the present invention
The clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention has significant curative effect for alcoholic fatty liver; Safety observe to be found, does not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (13)
1. a Chinese medicine composition for the treatment of alcoholic fatty liver, made by each crude drug of following weight portion: Herba Artemisiae Scopariae 15-35 part, Radix Puerariae 15-30 part, Poria 15-35 part, Rhizoma Imperatae 10-25 part, Herba Eupatorii 10-25 part, Semen Cassiae 10-25 part, green tea 4-10 part, Fructus Crataegi 5-12 part, Radix Salviae Miltiorrhizae 5-12 part, Herba Artemisiae Annuae 5-12 part, Cortex Lycii 5-12 part, Fructus Arctii 8-15 part, Caulis Bambusae In Taenia 4-10 part, Rhizoma Polygonati 4-10 part, Fructus Ligustri Lucidi 4-10 part, Rhizoma Chuanxiong 4-10 part and Radix Glycyrrhizae 2-8 part.
2. according to the Chinese medicine composition for the treatment of alcoholic fatty liver claimed in claim 1, it is characterized in that, the weight portion of each crude drug is: 30 parts of Herba Artemisiae Scopariae, 25 parts of Radix Puerariaes, 30 parts, Poria, 20 parts of Rhizoma Imperataes, 20 parts of Herba Eupatoriis, 20 parts of Semen Cassiaes, 8 parts of green tea, 10 parts of Fructus Crataegis, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Herba Artemisiae Annuaes, 10 parts of Cortex Lycii, 12 parts of Fructus Arctiis, 8 parts of Caulis Bambusae In Taenia, 8 parts of Rhizoma Polygonatis, 8 parts of Fructus Ligustri Lucidi, 8 parts of Rhizoma Chuanxiongs, 4 parts, Radix Glycyrrhizae.
3. Chinese medicine composition for the treatment of alcoholic fatty liver, each crude drug by following weight portion is made: Herba Artemisiae Scopariae 15-35 part, Radix Puerariae 15-30 part, Poria 15-35 part, Rhizoma Imperatae 10-25 part, Herba Eupatorii 10-25 part, Semen Cassiae 10-25 part, green tea 4-10 part, Fructus Crataegi 5-12 part, Radix Salviae Miltiorrhizae 5-12 part, Herba Artemisiae Annuae 5-12 part, Cortex Lycii 5-12 part, Fructus Arctii 8-15 part, Caulis Bambusae In Taenia 4-10 part, Rhizoma Polygonati 4-10 part, Fructus Ligustri Lucidi 4-10 part, Rhizoma Chuanxiong 4-10 part, Radix Glycyrrhizae 2-8 part, Herba Dendrobii 8-15 part, Radix Scutellariae 8-15 part, Cornu Saigae Tataricae 3-8 part, Cortex Moutan 6-12 part, Radix Gentianae 6-12 part, Flos Chrysanthemi 5-10 part, Fructus Gardeniae 5-10 part and Aloe 5-10 part.
4. according to the Chinese medicine composition for the treatment of alcoholic fatty liver claimed in claim 3, it is characterized in that, the weight portion of each crude drug is: 30 parts of Herba Artemisiae Scopariae, 25 parts of Radix Puerariaes, 30 parts, Poria, 20 parts of Rhizoma Imperataes, 20 parts of Herba Eupatoriis, 20 parts of Semen Cassiaes, 8 parts of green tea, 10 parts of Fructus Crataegis, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Herba Artemisiae Annuaes, 10 parts of Cortex Lycii, 12 parts of Fructus Arctiis, 8 parts of Caulis Bambusae In Taenia, 8 parts of Rhizoma Polygonatis, 8 parts of Fructus Ligustri Lucidi, 8 parts of Rhizoma Chuanxiongs, 4 parts, Radix Glycyrrhizae, 12 parts of Herba Dendrobii, 12 parts of Radix Scutellariaes, 5 parts of Cornu Saigae Tataricae, 10 parts of Cortex Moutans, 10 parts of Radix Gentianaes, 8 parts of Flos Chrysanthemis, 8 parts of Fructus Gardeniaes, 8 parts of Aloes.
5. Chinese medicine composition for the treatment of alcoholic fatty liver, each crude drug by following weight portion is made: Herba Artemisiae Scopariae 15-35 part, Radix Puerariae 15-30 part, Poria 15-35 part, Rhizoma Imperatae 10-25 part, Herba Eupatorii 10-25 part, Semen Cassiae 10-25 part, green tea 4-10 part, Fructus Crataegi 5-12 part, Radix Salviae Miltiorrhizae 5-12 part, Herba Artemisiae Annuae 5-12 part, Cortex Lycii 5-12 part, Fructus Arctii 8-15 part, Caulis Bambusae In Taenia 4-10 part, Rhizoma Polygonati 4-10 part, Fructus Ligustri Lucidi 4-10 part, Rhizoma Chuanxiong 4-10 part, Radix Glycyrrhizae 2-8 part, Polyporus 8-15 part, Rhizoma Alismatis 6-12 part, Cortex Phellodendri 6-12 part, Herba Lysimachiae 5-10 part, Herba Lobeliae Chinensis 5-10 part, Semen Plantaginis 5-10 part and Medulla Tetrapanacis 4-8 part.
6. according to the Chinese medicine composition for the treatment of alcoholic fatty liver claimed in claim 5, it is characterized in that, the weight portion of each crude drug is: 30 parts of Herba Artemisiae Scopariae, 25 parts of Radix Puerariaes, 30 parts, Poria, 20 parts of Rhizoma Imperataes, 20 parts of Herba Eupatoriis, 20 parts of Semen Cassiaes, 8 parts of green tea, 10 parts of Fructus Crataegis, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Herba Artemisiae Annuaes, 10 parts of Cortex Lycii, 12 parts of Fructus Arctiis, 8 parts of Caulis Bambusae In Taenia, 8 parts of Rhizoma Polygonatis, 8 parts of Fructus Ligustri Lucidi, 8 parts of Rhizoma Chuanxiongs, 4 parts, Radix Glycyrrhizae, 12 parts of Polyporus, 10 parts of Rhizoma Alismatis, 10 parts of Cortex Phellodendris, 8 parts of Herba Lysimachiaes, 8 parts of Herba Lobeliae Chinensis, 8 parts of Semen Plantaginiss, 6 parts of Medulla Tetrapanaciss.
7. Chinese medicine composition for the treatment of alcoholic fatty liver, each crude drug by following weight portion is made: Herba Artemisiae Scopariae 15-35 part, Radix Puerariae 15-30 part, Poria 15-35 part, Rhizoma Imperatae 10-25 part, Herba Eupatorii 10-25 part, Semen Cassiae 10-25 part, green tea 4-10 part, Fructus Crataegi 5-12 part, Radix Salviae Miltiorrhizae 5-12 part, Herba Artemisiae Annuae 5-12 part, Cortex Lycii 5-12 part, Fructus Arctii 8-15 part, Caulis Bambusae In Taenia 4-10 part, Rhizoma Polygonati 4-10 part, Fructus Ligustri Lucidi 4-10 part, Rhizoma Chuanxiong 4-10 part, Radix Glycyrrhizae 2-8 part, Radix Angelicae Sinensis 6-12 part, Rhizoma Cyperi 8-15 part, Rhizoma Corydalis 8-15 part, Radix Aucklandiae 6-12 part, Radix Curcumae 5-10 part, Fructus Aurantii 5-10 part, Fructus Toosendan 5-10 part and Retinervus Luffae Fructus 3-8 part.
8. according to the Chinese medicine composition for the treatment of alcoholic fatty liver claimed in claim 7, it is characterized in that, the weight portion of each crude drug is: 30 parts of Herba Artemisiae Scopariae, 25 parts of Radix Puerariaes, 30 parts, Poria, 20 parts of Rhizoma Imperataes, 20 parts of Herba Eupatoriis, 20 parts of Semen Cassiaes, 8 parts of green tea, 10 parts of Fructus Crataegis, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Herba Artemisiae Annuaes, 10 parts of Cortex Lycii, 12 parts of Fructus Arctiis, 8 parts of Caulis Bambusae In Taenia, 8 parts of Rhizoma Polygonatis, 8 parts of Fructus Ligustri Lucidi, 8 parts of Rhizoma Chuanxiongs, 4 parts, Radix Glycyrrhizae, 9 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Cyperis, 12 parts of Rhizoma Corydalis, 9 parts of the Radix Aucklandiae, 8 parts of Radix Curcumaes, 8 parts of Fructus Aurantiis, 8 parts of Fructus Toosendans, 5 parts of Retinervus Luffae Fructuss.
9. Chinese medicine composition for the treatment of alcoholic fatty liver, each crude drug by following weight portion is made: Herba Artemisiae Scopariae 15-35 part, Radix Puerariae 15-30 part, Poria 15-35 part, Rhizoma Imperatae 10-25 part, Herba Eupatorii 10-25 part, Semen Cassiae 10-25 part, green tea 4-10 part, Fructus Crataegi 5-12 part, Radix Salviae Miltiorrhizae 5-12 part, Herba Artemisiae Annuae 5-12 part, Cortex Lycii 5-12 part, Fructus Arctii 8-15 part, Caulis Bambusae In Taenia 4-10 part, Rhizoma Polygonati 4-10 part, Fructus Ligustri Lucidi 4-10 part, Rhizoma Chuanxiong 4-10 part, Radix Glycyrrhizae 2-8 part, Rhizoma Dioscoreae 6-12 part, Fructus Setariae Germinatus 6-12 part, Fructus Hordei Germinatus 6-12 part, Massa Medicata Fermentata 8-15 part, Fructus Amomi 8-15 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Radix Ginseng 4-8 part and Pericarpium Citri Reticulatae 4-8 part.
10. according to the Chinese medicine composition for the treatment of alcoholic fatty liver claimed in claim 9, it is characterized in that, the weight portion of each crude drug is: 30 parts of Herba Artemisiae Scopariae, 25 parts of Radix Puerariaes, 30 parts, Poria, 20 parts of Rhizoma Imperataes, 20 parts of Herba Eupatoriis, 20 parts of Semen Cassiaes, 8 parts of green tea, 10 parts of Fructus Crataegis, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Herba Artemisiae Annuaes, 10 parts of Cortex Lycii, 12 parts of Fructus Arctiis, 8 parts of Caulis Bambusae In Taenia, 8 parts of Rhizoma Polygonatis, 8 parts of Fructus Ligustri Lucidi, 8 parts of Rhizoma Chuanxiongs, 4 parts, Radix Glycyrrhizae, 9 parts of Rhizoma Dioscoreaes, 9 parts of Fructus Setariae Germinatuss, 9 parts, Fructus Hordei Germinatus, 12 parts of Massa Medicata Fermentata, 12 parts of Fructus Amomis, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Radix Ginsengs, 6 parts of Pericarpium Citri Reticulataes.
11., according to any one described Chinese medicine composition of claim 1-10, it is characterized in that: it is prepared into any acceptable oral drug preparation clinically; Described oral drug preparation is pill, powder, granule, capsule, tablet or oral liquid.
12. a method for preparing any one described Chinese medicine composition of claim 1-10 comprises the following steps:
(1), take each crude drug by described weight proportion;
(2), each crude drug water is decocted, merge decoction liquor, filter, filtrate is condensed into clear paste, adds the adjuvant of preparations shaping, and preparations shaping, obtain.
13. the purposes of any one described Chinese medicine composition of claim 1-10 in preparation treatment alcoholic fatty liver medicine.
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| CN103083573B (en) * | 2013-01-20 | 2014-04-02 | 李孝芹 | Traditional Chinese medicine used for treating alcoholic fatty liver |
| CN103142944B (en) * | 2013-04-03 | 2014-05-28 | 陈莉 | Traditional Chinese medicine composition for treating alcoholic liver |
| CN103272146B (en) * | 2013-06-24 | 2014-11-19 | 天津市石天药业有限责任公司 | Medicine composition used for preventing and treating alcoholic fatty liver and preparation method thereof |
| CN103598364B (en) * | 2013-10-29 | 2014-11-05 | 安徽博格生物科技有限公司 | Tea product capable of dispelling effects of alcohol and protecting liver, and preparation method thereof |
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| CN103977112B (en) * | 2014-05-28 | 2016-08-24 | 新乡医学院第一附属医院 | A kind of Chinese medicine treating alcoholic liver |
| CN104524353A (en) * | 2014-12-06 | 2015-04-22 | 唐云峰 | Traditional Chinese medicinal composition for treating infantile jaundice |
| CN104815298A (en) * | 2015-05-31 | 2015-08-05 | 高忠青 | Traditional Chinese medicine for treating alcoholic liver disease |
| CN105125871A (en) * | 2015-09-28 | 2015-12-09 | 卞文青 | Medicine preparation for treating fatty liver |
| CN105327045A (en) * | 2015-11-18 | 2016-02-17 | 潘建荣 | Lipid-lowering traditional Chinese medicine for treating NAFLD (non-alcoholic fatty liver diseases) and treatment method |
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