CN104840891A - Traditional Chinese medicine preparation used for treating alcoholic cardiomyopathy and preparation method thereof - Google Patents
Traditional Chinese medicine preparation used for treating alcoholic cardiomyopathy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation used for treating alcoholic cardiomyopathy. The preparation takes mulberry twig, kudzuvine root, giant knotweed rhizome, cassia twig, safflower, root of phoenix tree, Chinese angelica, radix rhodiolae, Szechuan lovage rhizome, radix bupleuri, turmeric root-tuber, Chinese rose flower, nutgrass galingale rhizome processed with vinegar, finger citron, radix astragali, rhizoma corydalis, Danshen root, peach seed, glabrous greenbrier rhizome, frankincense, snakegourd fruit, medicinal cyathula root, Mongolian dandelion herb, Chinese honeylocust spine and liquorice root as raw materials, and belongs to the field of traditional Chinese medicine invention. The preparation is prepared by a special method after washing, dicing and pretreating the traditional Chinese medicines according to the different characteristics of the traditional Chinese medicines and mixing the traditional Chinese medicines in proportion. The preparation has the functions of dispelling wind and expelling evil, promoting qi circulation and inducing diuresis, promoting blood circulation to remove blood stasis and soothing the liver and removing toxins, and is unique in combination and preparation methods. Through clinical verification, the medicine has obvious treatment effects and short treatment cycle, is low in price, does not have adverse effects or any toxic or side effect, and has an extensive market application prospect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for alcoholic cardiomyopathy, the invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Morbidity and the Ethanol intakes a large amount of for a long time of alcoholic cardiomyopathy (alcoholic cardiomyopathy.ACM) have substantial connection, the multiple male being born in 30 ~ 55 years old, usually history of being excessively addicted to drink for more than 10 years is had, diverse clinical manifestations, main manifestations is cardiac insufficiency and arrhythmia, comprises the cardinal symptoms such as cardiac dilatation, congestive heart failure, arrhythmia, chest pain, blood pressure change.Alcoholic cardiomyopathy is the result of directly poisoning cardiac muscle due to ethanol and metabolite acetaldehyde etc. thereof.The direct toxic action of ethanol to myocardial cell is mainly manifested in following several respects: the 1. integrity of ethanol infringement myocardial cell membrane, makes membrane passage increase, efflux of K+ ions in cell, and the example balance maintaining membrane voltage is not normal; 2. alcohol metabolism product can with many protein binding, make the normal physiological function of some proteins lose, and make the immunoreation of original antigenic structure change triggers, thus cause myocardial damage; 3. can promote the release of catecholamine after acetaldehyde enters blood circulation, the long-term stimulation by catecholamine amine of cardiac muscle, can make myocardial hypertrophy, concurrent arrhythmia; 5. long-term heavy drinking also can cause human nutrition to lack of proper care, and easily causes vitamin deficiency, and especially B vitamin lacks, and also can increase the weight of cardiac insufficiency; 6. in addition, containing the noxious substance such as cobalt, lead in some additive of drinks, long-term drink can cause poisoning or myocardial damage.Interaction for above-mentioned reasons and impact finally can cause the generation of alcoholic cardiomyopathy.
How Chinese traditional treatment not for the medicine typing of alcoholic cardiomyopathy, but is carried out opinion from myocardiac pattern of syndrome and is controlled.Myocardiac tcm syndrome differentiation and typing has: the weak card of the motive, syndrome of deficiency of both qi and yin, gas sun two deficiency syndrome, but alcoholic cardiomyopathy is obviously different with dilated cardiomyopathy inherent mechanism, the former for the domination of pathogen be main good prognosis, the latter is weakened body resistance is main poor prognosis.And current clinically manyly to control from deficiency syndrome opinion, real person reality again, cause getting half the result with twice the effort.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for alcoholic cardiomyopathy, it is remarkable that this Chinese medicine preparation has therapeutic effect for treatment alcoholic cardiomyopathy, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.
Inventor is in clinical treatment practice for many years, and according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out to be used for the treatment of the new formula of the Chinese medicine preparation of alcoholic cardiomyopathy repeatedly.The present invention has that therapeutic effect is remarkable, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.
The effect of Chinese medicine of the present invention:
Wherein:
Ramulus Mori: be the dry twig of moraceae plants Mulberry Morus alba L..Nature and flavor: micro-hardship are flat.Return Liver Channel.Effect: wind-damp dispelling, sharp joint.For takeing on arm, joint aches is numb.Record in essentials of Matea Medica: sharp joint, promoting fluid production, row water dispels the wind.
Radix Puerariae: be the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi or Radix Puerariae rattan Pueraria thomsonii Benth..Nature and flavor: sweet, pungent, cool.Return spleen, stomach warp.Effect: thirsty, quenches one's thirst, measles without adequate eruption, and hematodiarrhoea, has loose bowels; Hypertension neck pain.Record in " herbal classic ": master quenches one's thirst, and body is too warm, vomiting, all numbness, play cloudy gas, separate all poison.
Rhizoma Polygoni Cuspidati: be polygonaceae plant Rhizoma Polygoni Cuspidati Polygonum cuspidatum Sieb. et Zucc., dry rhizome and root.Nature and flavor: micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian.Effect: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.Record in " Guizhou side's medicine among the people collection ": astringing to arrest bleeding, control hemorrhoid complicated by anal fistula, curing rheumatism, deliver cold expelling, dissipating blood stasis blood.
Ramulus Cinnamomi: be the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Spring, Xia Erji gather, and except defoliation, dry, or section is dried.Nature and flavor: acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Cure mainly diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Flos Carthami: be the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: pungent, temperature.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache." detailed outline ": invigorate blood circulation, moisturizes, pain relieving, loose swollen, stimulates the menstrual flow.
Radix firmianae: be the root of Sterculiaceae plant Firmiana platanifolia (Linn. f.) Marsili Firmiana plantanifolia (L.f.) Marsili.Nature and flavor: sweet; Property is put down.Gui Jing: lung; Liver; Kidney; Large intestine channel effect: expelling wind and removing dampness; Regulating menstruation, hemostasis; Detoxification sore treatment.Main air wets arthralgia; Spit blood; Discharging fresh blood stool; Have through uncomfortable; Traumatic injury.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, acrid, warm.Return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.Record in " not Lu ": warming middle-JIAO to relieve pain, fill in except in objective blood, middle puerperal tetanus, no sweating, arthralgia chiefly caused by damp pathogen, attacked by pestiferous factors is courteous, cold caused by deficiency, mend five and hide, granulation promoting meat.
Radix Rhodiolae: be Crassulaceae Rhodida plant Radix Rhodiolae Rhodiola saera (Prain) Fu, with all herbal medicine.9 ~ October gathers, and cleans and dries.Nature and flavor: sweet, puckery, cold.Return lung meridian.Effect: clearing away lung-heat to relieve cough, hemostasis, leukorrhagia stopping.For cough due to lung-heat, spitting of blood, leucorrhea; Traumatic injury is controlled in external, burn and scald.
Rhizoma Chuanxiong: be samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort.(or Ligusticum wallichii Franch.) dry rhizome.Nature and flavor: pungent, temperature.Return liver, gallbladder, pericardium channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Record in " Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjusts many arteries and veins, and broken Disorder ties stagnated blood, supports fresh blood, puts on flesh, serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, and scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood.
Radix Bupleuri: be the dry root of umbelliferae bupleurum Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd..Nature and flavor: bitter, are slightly cold.Return liver, gallbladder meridian.Effect: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.Record in " detailed outline ": control yang-energy and sink, suppressing the hyperactive liver, gallbladder, three burnt, envelope is mutually fiery.
Radix Curcumae: be the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor: pungent, bitter, cold.Return liver, the heart, lung meridian.Effect: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.Record in essentials of Matea Medica: " circulation of qi promoting, resolving depression; Let out blood, removing blood stasis with potent drugs.Cool heat in the heart, loose stagnation of liver-QI.
Flos Rosae Chinensis: be the dried floral of rosaceous plant Chinese rose Rosa chinensis Jacq..Nature and flavor: sweet, temperature.Return Liver Channel.Effect: promoting blood flow to regulate menstruation, loose poison detumescence.Record in " modern Practical Chinese medicinal ": promoting blood flow to regulate menstruation.Control difficult menstruation, menstrual phase contracture is suffered from abdominal pain. and edema of the dorsum of the foot poison is smash in external, can reducing swelling and alleviating pain.
Rhizoma Cyperi (processed with vinegar): be the dry rhizome processed product of sedge dried tuber Cyperus rotundus L..Nature and flavor: pungent, micro-hardship, micro-sweet are flat.Return liver, spleen, tri-jiao channel.Effect: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.Record in " detailed outline ": loose seasonal epidemic pathogens is trembled with fear epidemic disease, and profit three is burnt, and separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, the moon wait uncomfortable, before tire puerperal all kinds of diseases and ailments.
Fructus Citri Sarcodactylis: be the dry fruit of Rutaceae citrus plant Fructus Citri Sarcodactylis Citrus medica L. var. sarcodactylis Swingle.Nature and flavor: pungent, bitter, sour, temperature.Return liver, spleen, lung meridian.Effect: liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.
The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, temperature.Return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Rhizoma Corydalis: be the dry tuber of papaveraceae plant corydalis Corydalis yanhusuo W. T. Wang.Nature and flavor: pungent, bitter, temperature.Return liver, spleen channel.Effect: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.Record in " Japan hanako materia medica ": except wind, control gas, warm waist knee joint, broken disease addiction, flutter damage blood stasis, fall tire, and sudden and violent lumbago.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge..Nature and flavor: bitter, are slightly cold.GUIXIN, Liver Channel.Effect: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Record in " the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful punching seized with terror, palpitation with fear is insomnia.
Semen Persicae: be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Nature and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.Record in " herbal classic ": main blood stasis, blood closes lump in the abdomen, pathogen, kills small worm." not Lu ": only cough with dyspnea, disappear hardness in the epigastrium, and except soldier hits blood cruelly, broken lump in the abdomen, promotes blood circulation, pain relieving.
Rhizoma Smilacis Glabrae: be the dry rhizome of liliaceous plant smilacis glabra Smilax glabra Roxb..Nature and flavor: sweet, light are flat.Gui Jing: return liver, stomach warp.Effect: dehumidifying, removing toxic substances, easing joint movement.For damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies, syphilis and the limbs contracture caused by mercurialism, bones and muscles pain.Record in " book on Chinese herbal medicine is new again ": damp eliminating heat, relieving rigidity of muscles and joints.
Olibanum: be Burseraceae Boswellia carterii platymiscium Boswellia carterii Boswellia carterii Birdw. [B. sacra Fluek.], medicine glue XIANGSHU B. bhawdajiana Birdw. and wild Boswellia carterii B. neglecta M. Moore etc., the oleo-gum-resin that its trunk skin zone wound oozes out.Nature and flavor: pungent, bitter, temperature.Effect: promoting blood circulation and stopping pain.For all pains of trusted subordinate, the contracture of muscle arteries and veins, traumatic injury, sore, carbuncle and painful swelling; Externally used detumescence granulation promoting.Record in " detailed outline ": all poison of eliminating carbuncle cellulitis, the heart is protected in Tuoli, and analgesic therapy of invigorating blood circulation, stretches muscle, controls married woman's difficult labour, injured.
Fructus Trichosanthis: be the dry mature fruit of cucurbitaceous plant Fructus Trichosanthis Trichosanthes kirilowii Maxim. or trichosanthes rosthornii Harms Trichosan-thes rosthornii Harms.Nature and flavor: sweet, micro-hardship, cold.Gui Jing: return lung, stomach, large intestine channel.Effect: clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.
Radix Cyathulae: be the dry root of Sichuan amaranthaceous plant Radix Achyranthis Bidentatae Achyranthes bidentata Blume..Nature and flavor: bitter, sour are flat.Return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.Record in " Traditional Chinese Medicine in Sichuan will ": expelling wind and removing dampness, stimulate the menstrual flow loose blood.Control cold-damp waist thigh bone pain, flaccidity of the lower limbs clonic spasm of the muscle, women's amenorrhea and lump in the abdomen, gonorrhea, hematuria, impotence, mistake are drowned.
Herba Taraxaci: be feverfew Herba Taraxaci Taraxacum mongolicum Hand.-Mazz., alkali ground Herba Taraxaci Taraxacum sinicum Kitag. or the dry herb belonging to several plants together.Spend spring to autumn when just opening and excavate, removing impurity, cleans, dries.Nature and flavor: bitter, sweet, cold.Return liver, stomach warp.Cure mainly heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Spina Gleditsiae: be the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Nature and flavor: pungent, temperature.Return liver, stomach warp.Effect: detumescence poison holding, evacuation of pus, parasite killing.For carbuncle from the beginning of or difficulty in discharging of pus; External treatment scabies leprosy.Record in " detailed outline ": control carbuncle, acute mastitis, scrofula caused by pathogenic wind malignant boil, retention of placenta, parasite killing.
Radix Glycyrrhizae Preparata: be the Preparation process product of Radix Glycyrrhizae.Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Side's solution of the present invention is: in side, the capable water of Ramulus Mori dispels the wind, Rhizoma Polygoni Cuspidati, Radix firmianae, Radix Cyathulae expelling wind and removing dampness, Rhizoma Chuanxiong dispels the wind circulation of qi promoting, above five kinds of Chinese medicine is monarch drug, the pathogeny of alcoholic cardiomyopathy is that long-term domination of pathogen invasion body causes, so dispel the wind, evil removing, circulation of qi promoting dampness removing are the bases for the treatment of alcoholic cardiomyopathy, and evil removing of first fundamentally dispeling the wind, circulation of qi promoting dampness removing, make disease obtain basic control.Flos Carthami, Radix Salviae Miltiorrhizae, Semen Persicae promoting blood circulation to remove blood stasis, Radix Angelicae Sinensis, Olibanum promoting blood circulation and stopping pain, Radix Curcumae regulating qi to disperse stagnation, the loose poison detumescence of Flos Rosae Chinensis, Rhizoma Cyperi (processed with vinegar), Rhizoma Corydalis promoting the circulation of QI to relieve pain, Radix Astragali diuresis toxin expelling, Rhizoma Smilacis Glabrae removing dampness and detoxicating, Herba Taraxaci diuresis eliminating stagnation, Liver Channel returned by above 12 taste medicines, as ministerial drug, on the one hand auxiliary monarch drug dispels the wind evil removing, circulation of qi promoting dampness removing; As ministerial drug, there is blood circulation promoting and blood stasis dispelling, removing toxic substances circulation of qi promoting effect on the other hand.Ramulus Cinnamomi is supporing yang activating QI, Radix Rhodiolae lung heat clearing profit gas, Radix Bupleuri is soothing the liver yang invigorating, Fructus Citri Sarcodactylis depressed liver-energy dispersing and QI regulating, Fructus Trichosanthis heat clearing away eliminating stagnation, Spina Gleditsiae detumescence toxin expelling, Radix Puerariae is quenched one's thirst dampness removing.Above seven flavor medicine, as adjuvant drug, can promote the evil removing of dispeling the wind of the monarch and his subjects two medicine, circulation of qi promoting dampness removing effect, can promote body blood circulation promoting and blood stasis dispelling, removing toxic substances circulation of qi promoting by using corrigent the monarch and his subjects two medicine again.Radix Glycyrrhizae Preparata makes medicine as in side, has coordinating the actions of various ingredients in a prescription drug effect, effectively promotes that body is to the absorption of active ingredient.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, have effect of effect of evil removing of dispeling the wind, circulation of qi promoting dampness removing, blood circulation promoting and blood stasis dispelling, soothing the liver removing toxic substances, effectively can treat alcoholic cardiomyopathy.
Another important feature of the present invention is that this Chinese medicine preparation contains abundant nutritional labeling, be rich in aminoacid and have more than 17 kinds, wherein essential amino acid has threonine, valine, methionine, isoleucine, leucine, lysine and phenylalanine, trace element containing needed by human has ferrum, chromium, copper, boron, manganese, strontium and zinc, several human body macroelement of another calcic, potassium, magnesium, phosphorus.Above nutritional labeling is all needed by human material, effectively can strengthen body immunity.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Ramulus Mori 22-26 part, Radix Puerariae 13-17 part, Rhizoma Polygoni Cuspidati 18-22 part, Ramulus Cinnamomi 13-17 part, Flos Carthami 7-11 part, Radix firmianae 18-22 part, Radix Angelicae Sinensis 16-20 part, Radix Rhodiolae 16-20 part, Rhizoma Chuanxiong 13-17 part, Radix Bupleuri 13-17 part, Radix Curcumae 13-17 part, Flos Rosae Chinensis 10-14 part, Rhizoma Cyperi (processed with vinegar) 13-17 part, Fructus Citri Sarcodactylis 13-17 part, Radix Astragali 48-52 part, Rhizoma Corydalis 28-32 part, Radix Salviae Miltiorrhizae 22-26 part, Semen Persicae 10-14 part, Rhizoma Smilacis Glabrae 16-20 part, Olibanum 8-12 part, Fructus Trichosanthis 22-26 part, Radix Cyathulae 13-17 part, Herba Taraxaci 18-22 part, Spina Gleditsiae 18-22 part, Radix Glycyrrhizae Preparata 7-11 part.
Wherein be preferably: Ramulus Mori 24 parts, Radix Puerariae 15 parts, Rhizoma Polygoni Cuspidati 20 parts, Ramulus Cinnamomi 15 parts, 9 parts, Flos Carthami, Radix firmianae 20 parts, Radix Angelicae Sinensis 18 parts, Radix Rhodiolae 18 parts, Rhizoma Chuanxiong 15 parts, Radix Bupleuri 15 parts, Radix Curcumae 15 parts, Flos Rosae Chinensis 12 parts, Rhizoma Cyperi (processed with vinegar) 15 parts, Fructus Citri Sarcodactylis 15 parts, the Radix Astragali 50 parts, Rhizoma Corydalis 30 parts, Radix Salviae Miltiorrhizae 24 parts, 12 parts, Semen Persicae, Rhizoma Smilacis Glabrae 18 parts, Olibanum 10 parts, Fructus Trichosanthis 24 parts, Radix Cyathulae 15 parts, Herba Taraxaci 20 parts, Spina Gleditsiae 20 parts, Radix Glycyrrhizae Preparata 9 parts.
A kind of preparation method of the Chinese medicine preparation for alcoholic cardiomyopathy is as follows:
Step one: by weight of the present invention, gets Rhizoma Cyperi (processed with vinegar), Ramulus Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Glycyrrhizae Preparata, grinding, crosses 120 mesh sieves, for subsequent use;
Step 2: by weight of the present invention, get Olibanum, grinding, crosses 120 mesh sieves, for subsequent use;
Step 3: by weight proportion of the present invention, get Radix Puerariae, Rhizoma Polygoni Cuspidati, Radix firmianae, Radix Bupleuri, Radix Curcumae, the Radix Astragali, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Semen Persicae, Rhizoma Smilacis Glabrae, Fructus Trichosanthis, Radix Cyathulae, Spina Gleditsiae medical material be placed in marmite, add the water of 8 times of volumes, after boiling, add Ramulus Mori, Flos Carthami, Radix Rhodiolae, Flos Rosae Chinensis, Fructus Citri Sarcodactylis, Herba Taraxaci intense fire infusion 40 ~ 50 minutes, add the water of 2 times of volumes again, Flos Albiziae, Semen Platycladi, Poria cum Radix Pini are dropped in marmite, intense fire infusion 15 ~ 20 minutes, fiery infusion of larding speech with literary allusions obtains filtrate in 20 ~ 30 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use;
Step 4: step 3 filtrate is poured while hot into the punching of step 2 powder and convert, mix with step one gained powder again, stir evenly, medicine soup is carried out concentrate and add ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, it is the thick paste of relative density 1.15 ~ 1.20 under 75 DEG C of environment by gained concentration of liquid medicine, by air-dry for thick paste pulverizing, add Mel, antiseptic, wetting agent etc., carry out beating, rubbing, one-tenth ball, dry, be distributed into bag, every bag containing effective ingredient 0.1g, both treatment alcoholic cardiomyopathy honeyed pill of the present invention.
Using method of the present invention: get honeyed pill, each one bag, oral in one hour after meal, every day 3 times.It within 7 days, is a course for the treatment of.
Medicine of the present invention has the effect of evil removing of dispeling the wind, circulation of qi promoting dampness removing, blood circulation promoting and blood stasis dispelling, soothing the liver removing toxic substances, and good analgesic effect, cheap, have no side effect, easy to use, the mode that this Chinese medicine preparation adopts is treated and can be reduced the injury of Western medicine to patient body, alleviate the slight illness of patient, according to clinical 240 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 82.5%, two the total effective rate course for the treatment of 95%.
Detailed description of the invention
Embodiment one: Ramulus Mori 24 parts, Radix Puerariae 15 parts, Rhizoma Polygoni Cuspidati 20 parts, Ramulus Cinnamomi 15 parts, 9 parts, Flos Carthami, Radix firmianae 20 parts, Radix Angelicae Sinensis 18 parts, Radix Rhodiolae 18 parts, Rhizoma Chuanxiong 15 parts, Radix Bupleuri 15 parts, Radix Curcumae 15 parts, Flos Rosae Chinensis 12 parts, Rhizoma Cyperi (processed with vinegar) 15 parts, Fructus Citri Sarcodactylis 15 parts, the Radix Astragali 50 parts, Rhizoma Corydalis 30 parts, Radix Salviae Miltiorrhizae 24 parts, 12 parts, Semen Persicae, Rhizoma Smilacis Glabrae 18 parts, Olibanum 10 parts, Fructus Trichosanthis 24 parts, Radix Cyathulae 15 parts, Herba Taraxaci 20 parts, Spina Gleditsiae 20 parts, Radix Glycyrrhizae Preparata 9 parts.
Embodiment two: Ramulus Mori 23 parts, Radix Puerariae 16 parts, Rhizoma Polygoni Cuspidati 21 parts, Ramulus Cinnamomi 16 parts, 8 parts, Flos Carthami, Radix firmianae 21 parts, Radix Angelicae Sinensis 19 parts, Radix Rhodiolae 19 parts, Rhizoma Chuanxiong 15 parts, Radix Bupleuri 15 parts, Radix Curcumae 15 parts, Flos Rosae Chinensis 13 parts, Rhizoma Cyperi (processed with vinegar) 15 parts, Fructus Citri Sarcodactylis 16 parts, the Radix Astragali 51 parts, Rhizoma Corydalis 31 parts, Radix Salviae Miltiorrhizae 25 parts, 12 parts, Semen Persicae, Rhizoma Smilacis Glabrae 18 parts, Olibanum 10 parts, Fructus Trichosanthis 24 parts, Radix Cyathulae 15 parts, Herba Taraxaci 21 parts, Spina Gleditsiae 21 parts, Radix Glycyrrhizae Preparata 10 parts.
Embodiment three: Ramulus Mori 25 parts, Radix Puerariae 16 parts, Rhizoma Polygoni Cuspidati 21 parts, Ramulus Cinnamomi 15 parts, 9 parts, Flos Carthami, Radix firmianae 21 parts, Radix Angelicae Sinensis 18 parts, Radix Rhodiolae 19 parts, Rhizoma Chuanxiong 15 parts, Radix Bupleuri 15 parts, Radix Curcumae 15 parts, Flos Rosae Chinensis 13 parts, Rhizoma Cyperi (processed with vinegar) 16 parts, Fructus Citri Sarcodactylis 15 parts, the Radix Astragali 50 parts, Rhizoma Corydalis 31 parts, Radix Salviae Miltiorrhizae 24 parts, 12 parts, Semen Persicae, Rhizoma Smilacis Glabrae 19 parts, Olibanum 11 parts, Fructus Trichosanthis 22 parts, Radix Cyathulae 16 parts, Herba Taraxaci 21 parts, Spina Gleditsiae 21 parts, Radix Glycyrrhizae Preparata 10 parts.
Just the clinical statistics data that patient uses medicine of the present invention below:
One, physical data
Accept out-patient 240 example for medical treatment, patient is divided at random observation group and each 120 examples of matched group, wherein male 200 example, women 40 example, M-F 5:1, max age 68 years old, minimal ages 34 years old, course of disease some months is not by several years etc.Every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).
Two, diagnostic criteria
1, often there is cardiac function and slightly to go down phenomenon in long-term alcoholic, shows as cardiopalmus, uncomfortable in chest, tired, unable etc.Severe patient is outstanding behaviours with congestive heart failure, is generally whole heart failure, but based on left heart failure, occurs the symptoms such as dyspnea, orthopnea and nocturnal paroxysmal dyspnea, also can have distension of jugular vein.
2, there is heavy drinking history (straight alcohol amount 125ml/ days, i.e. medicated beer 4 bottles or Chinese liquor 150g), continue to occur cardiopathic sings and symptoms in more than 10 years.
3, other heart diseases can be got rid of and namely should consider primary disease.Mandatory alleviating alcohol addiction 4 ~ 8 weeks, after active treatment, the state of an illness is improved rapidly, also supports the diagnosis of alcoholic cardiomyopathy.
Three, Therapeutic Method:
1, observation group is according to Medications Example one of the present invention, and weighting raw materials, by the treatment of invention implementation method, gets honeyed pill, each one bag, decoction being taken warmly in a hour after meal, every day 3 times.It within 7 days, is a course for the treatment of.
2, normal saline 100ml+ adenosine cyclophosphate 100mg, 10% glucose 500ml+ potassium chloride 1.5g+ insulin 12 units+magnesium sulfate 1.0g is given, according to state of an illness choice for use diuretic, cardiac tonic (low dose), vasodilator, ACEI, beta receptor blocking agent (rear application is stablized in the treatment such as cardiac function 4 grades of person's heart tonifying, diuresis).
Four, efficacy assessment standard:
Formulate with reference to " study of tcm new drug guideline " and NYNA grade scale:
1, effective: clinical cardinal symptom, sign are clearly better, cardiac function improves more than 2 grades;
2, effective: symptom takes a turn for the better, and cardiac function improves 1 grade;
3, invalid: cardinal symptom is without improvement or sb.'s illness took a turn for the worse.
Five, therapeutic outcome statistics:
Matched group result is added up
Use the Comparison of therapeutic situation of this Chinese medicine preparation two groups of patients, two courses for the treatment of
Wherein: total effective rate=cure rate+improvement rate
Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness in treatment alcoholic cardiomyopathy, effectively can improve the cure rate for the treatment of, Be very effective, cheap, have no adverse reaction and any toxic and side effects, there is wide market application foreground.
Model case and curative effect:
Case one, patient Wang, man, 56 years old, people from Qingdao City, came here and goes to a doctor on January 18th, 2010.Continuous more than ten years of drinking white spirit, every day 6-8 two, conscious sensation of oppression over the chest with shortness of breath two months ago, tells white frothy sputum, and after movable, cardiopalmus is obvious, and local hospital is diagnosed as dilated cardiomyopathy, and DeGrain after medication treatment, comes to go to a doctor.Be diagnosed as alcoholic cardiomyopathy.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of of treatment, effect is very good, and chest distress and palpitation symptoms symptom greatly alleviates, and thoroughly cure after two courses for the treatment of, clinical symptoms disappears completely, and Effect of follow-up visit by telephone does not recur for 1 year.
Case two, patient Lee, man, 49 years old, people from Linyi, Shandong.Come here on May 14th, 2010 to go to a doctor, symptom is as follows after diagnosing: 8 years history of drinking history, because labour's property is uncomfortable in chest, tachypnea, two lower limbs edema, nocturnal paroxysmal dyspnea, be admitted to hospital, be diagnosed as alcoholic cardiomyopathy on inspection.Then use made preparation in our embodiment one, and selected preparation method, after a course for the treatment of of treatment, effect is very good, and thoroughly cure after two courses for the treatment of, clinical symptoms disappears completely, and Effect of follow-up visit by telephone does not recur half a year.
Claims (4)
1. the Chinese medicine preparation for alcoholic cardiomyopathy, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Ramulus Mori 22-26 part, Radix Puerariae 13-17 part, Rhizoma Polygoni Cuspidati 18-22 part, Ramulus Cinnamomi 13-17 part, Flos Carthami 7-11 part, Radix firmianae 18-22 part, Radix Angelicae Sinensis 16-20 part, Radix Rhodiolae 16-20 part, Rhizoma Chuanxiong 13-17 part, Radix Bupleuri 13-17 part, Radix Curcumae 13-17 part, Flos Rosae Chinensis 10-14 part, Rhizoma Cyperi (processed with vinegar) 13-17 part, Fructus Citri Sarcodactylis 13-17 part, Radix Astragali 48-52 part, Rhizoma Corydalis 28-32 part, Radix Salviae Miltiorrhizae 22-26 part, Semen Persicae 10-14 part, Rhizoma Smilacis Glabrae 16-20 part, Olibanum 8-12 part, Fructus Trichosanthis 22-26 part, Radix Cyathulae 13-17 part, Herba Taraxaci 18-22 part, Spina Gleditsiae 18-22 part, Radix Glycyrrhizae Preparata 7-11 part.
2. the Chinese medicine preparation for alcoholic cardiomyopathy according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Ramulus Mori 24 parts, Radix Puerariae 15 parts, Rhizoma Polygoni Cuspidati 20 parts, Ramulus Cinnamomi 15 parts, 9 parts, Flos Carthami, Radix firmianae 20 parts, Radix Angelicae Sinensis 18 parts, Radix Rhodiolae 18 parts, Rhizoma Chuanxiong 15 parts, Radix Bupleuri 15 parts, Radix Curcumae 15 parts, Flos Rosae Chinensis 12 parts, Rhizoma Cyperi (processed with vinegar) 15 parts, Fructus Citri Sarcodactylis 15 parts, the Radix Astragali 50 parts, Rhizoma Corydalis 30 parts, Radix Salviae Miltiorrhizae 24 parts, 12 parts, Semen Persicae, Rhizoma Smilacis Glabrae 18 parts, Olibanum 10 parts, Fructus Trichosanthis 24 parts, Radix Cyathulae 15 parts, Herba Taraxaci 20 parts, Spina Gleditsiae 20 parts, Radix Glycyrrhizae Preparata 9 parts.
3. the Chinese medicine preparation for alcoholic cardiomyopathy according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is honeyed pill.
4. for a preparation method for the Chinese medicine preparation of alcoholic cardiomyopathy, it is characterized in that, preparation method is as follows: step one: by weight of the present invention, gets Rhizoma Cyperi (processed with vinegar), Ramulus Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Glycyrrhizae Preparata, grinding, crosses 120 mesh sieves, for subsequent use;
Step 2: by weight of the present invention, get Olibanum, grinding, crosses 120 mesh sieves, for subsequent use; Step 3: by weight proportion of the present invention, get Radix Puerariae, Rhizoma Polygoni Cuspidati, Radix firmianae, Radix Bupleuri, Radix Curcumae, the Radix Astragali, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Semen Persicae, Rhizoma Smilacis Glabrae, Fructus Trichosanthis, Radix Cyathulae, Spina Gleditsiae medical material be placed in marmite, add the water of 8 times of volumes, after boiling, add Ramulus Mori, Flos Carthami, Radix Rhodiolae, Flos Rosae Chinensis, Fructus Citri Sarcodactylis, Herba Taraxaci intense fire infusion 40 ~ 50 minutes, add the water of 2 times of volumes again, Flos Albiziae, Semen Platycladi, Poria cum Radix Pini are dropped in marmite, intense fire infusion 15 ~ 20 minutes, fiery infusion of larding speech with literary allusions obtains filtrate in 20 ~ 30 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use; Step 4: step 3 filtrate is poured while hot into the punching of step 2 powder and convert, mix with step one gained powder again, stir evenly, medicine soup is carried out concentrate and add ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, it is the thick paste of relative density 1.15 ~ 1.20 under 75 DEG C of environment by gained concentration of liquid medicine, by air-dry for thick paste pulverizing, add Mel, antiseptic, wetting agent etc., carry out beating, rubbing, one-tenth ball, dry, be distributed into bag, every bag containing effective ingredient 0.1g, both treatment alcoholic cardiomyopathy honeyed pill of the present invention.
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| CN105194623A (en) * | 2015-10-27 | 2015-12-30 | 菏泽海诺知识产权服务有限公司 | Traditional Chinese medicine treating alcoholic cardiomyopathy |
| CN111544443A (en) * | 2020-06-16 | 2020-08-18 | 南通大学 | Pharmaceutical composition for preventing or treating cardiomyopathy |
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| CN103251885A (en) * | 2013-04-29 | 2013-08-21 | 严中明 | Traditional Chinese medicine composition for treating dilated cardiomyopathy and preparation method thereof |
| CN103536806A (en) * | 2013-11-09 | 2014-01-29 | 王墨茹 | Traditional Chinese medicine composition for treating alcoholic myocardiopathy |
| CN104258351A (en) * | 2014-10-13 | 2015-01-07 | 张红梅 | Traditional Chinese medicine preparation for treating alcoholic cardiomyopathy and preparation method of preparation |
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| CN103251885A (en) * | 2013-04-29 | 2013-08-21 | 严中明 | Traditional Chinese medicine composition for treating dilated cardiomyopathy and preparation method thereof |
| CN103536806A (en) * | 2013-11-09 | 2014-01-29 | 王墨茹 | Traditional Chinese medicine composition for treating alcoholic myocardiopathy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105194623A (en) * | 2015-10-27 | 2015-12-30 | 菏泽海诺知识产权服务有限公司 | Traditional Chinese medicine treating alcoholic cardiomyopathy |
| CN111544443A (en) * | 2020-06-16 | 2020-08-18 | 南通大学 | Pharmaceutical composition for preventing or treating cardiomyopathy |
| CN111544443B (en) * | 2020-06-16 | 2022-03-11 | 南通大学 | Pharmaceutical composition for preventing or treating cardiomyopathy |
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Application publication date: 20150819 |