CN102755516B - Traditional Chinese medicine preparation for inhibiting human immunodeficiency virus and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for inhibiting human immunodeficiency virus. The traditional Chinese medicine preparation is characterized by being prepared from the following traditional Chinese medicines in parts by weight: 10-30 parts of radix astragali, 5-15 parts of rhizoma atractylodis macrocephalae, 5-15 parts of radix paeoniae alba, 5-15 parts of codonopsis pilosula, 5-15 parts of radix rehmanniae preparata, 5-15 parts of lycium barbarum, 5-15 parts of fructus corni, 5-15 parts of fructus psoraleae, 5-15 parts of radix ophiopogonis, 10-20 parts of lucid ganoderma, 5-15 parts of human placenta, 15-30 parts of gecko, 5-15 parts of cassia twig and 5-15 parts of Chinese date. In accordance with the traditional Chinese medicine clinical characteristics of AIDs and the Clinical Technical Solution for Treating AIDs with Traditional Chinese Medicine (on Trial) formulated by the state administration of traditional Chinese medicine and in combination with the factors of climatic characteristics of Guangxi, constitutive characters, environmental factors, people conditions and the like, a therapeutic medicine suitable for most of the infected people in Guangxi is created, and the medicine has an effect of improving the related symptoms and signs of AIDs. The traditional Chinese medicine preparation for treating AIDs disclosed by the invention has a better effect of improving weakness, anorexia, breath shortness and lumbago when combined with antiviral drug than the treatment with antiviral drug only.

Description

Suppress Chinese medicine preparation of HIV (human immunodeficiency virus) and preparation method thereof

Technical field

The invention discloses a kind of medicine that suppresses HIV (human immunodeficiency virus) and preparation method thereof, the pharmaceutical formulation of auxiliary treatment AIDS that the Chinese medicine of specifically take is raw material and the preparation method of related preparations thereof, belong to the field of Chinese medicines.

Background technology

Acquired immune deficiency syndrome (AIDS), the i.e. transliteration of acquired immune deficiency syndrome (AIDS) (translate again: acquired immunity defect syndrome), english abbreviation AIDS(Acquired Immune Deficiency Syndrome).Acquired immune deficiency syndrome (AIDS) originates from Africa, after by immigrant, bring the U.S. into.On June 5th, 1981, U.S. Atlanta Center for Disease Control (CDC) has briefly introduced the medical history of 5 routine AIDS patients on < < incidence and mortality weekly > >, and this is the formal record of relevant acquired immune deficiency syndrome (AIDS) for the first time in the world.Nineteen eighty-two, this disease is named as " acquired immune deficiency syndrome (AIDS) ".In the near future, acquired immune deficiency syndrome (AIDS) rapid spread is to each continent.1985, foreign nationality to travel in China young ill move in after BJ Union Hospital very fast dead, after be proved and die from acquired immune deficiency syndrome (AIDS).Zhe Shi China finds acquired immune deficiency syndrome (AIDS) for the first time.Acquired immune deficiency syndrome (AIDS) is seriously threatening the mankind's existence, has caused the great attention of World Health Organization (WHO) and national governments.Acquired immune deficiency syndrome (AIDS) propagation is worldwide more and swifter and more violent, and the mankind's health and social development in serious threat, has become the fourth-largest killer who threatens health of people.UNAIDS's declaration on May 30th, 2006 is since confirming acquired immune deficiency syndrome (AIDS) first in June, 1981, and between 25 years, whole world accumulative total has 6,500 ten thousand people's aids infections poison, and wherein 2,500,000 people are dead.To the end of the year 2005, the whole world has 3,860 ten thousand patients infected hivs, and newly-increased patients infected hiv 4,100,000 people, separately have 2,800,000 people to die from acquired immune deficiency syndrome (AIDS) then.According to the < < of UNAIDS 2008 Summary of HIV/AIDS Epidemic report > >, point out, 2007, the effort that the whole world prevents and treats acquired immune deficiency syndrome (AIDS) makes remarkable progress, HIV/AIDS Epidemic presents and defuses a situation first, newly-increased HIV patient's quantity and all occur declining because of the number of acquired immune deficiency syndrome (AIDS) death.The newly-increased HIV patient 2,700,000 in the whole world in 2007, has declined 300,000 than calendar year 2001; Because the number of acquired immune deficiency syndrome (AIDS) death is 2,000,000, decline 200,000 than calendar year 2001.

For acquired immune deficiency syndrome (AIDS), there is no at present the Therapeutic Method of determined curative effect, integrally-regulated by body of the traditional Chinese medical science, dialectically combines with differential diagnosis of diseases, can improve patient's symptom, improve life quality, alleviate the toxic and side effects of antiviral drugs, improve body's immunity, reduce the incidence rate of opportunistic infection.These advantages of Chinese traditional treatment have demonstrated powerful vitality, also for not accepting the patient of antiviral therapy, provide new treatment approach simultaneously.It is introduced, patients infected hiv is counted from initial infection, be through the several years, even reach 10 years or just can develop into AIDS patients after longer incubation period.AIDS patients there will be multi-infection because resistivity extremely declines, as herpes zoster, Fungi Infection of Oral, pulmonary tuberculosis, the enteritis that specific disease pathogenic microorganism causes, pneumonia, encephalitis, candidiasis, the severe infections that the multiple pathogens such as lung sac worm cause etc., usually there is malignant tumor in the later stage, until consume because of long-term, and cachexia and death.

Although the numerous medical research personnel in the whole world have paid huge effort, not yet develop so far the specific medicament of radical cure acquired immune deficiency syndrome (AIDS), not can be used for the effective vaccine of prevention yet.

Acquired immune deficiency syndrome (AIDS) is very fast at more western regional spread speeds ratios.From Guangxi Zhuang Autonomous Region Department of Public Health, learn, by October 31 this year, Guangxi accumulative total reports AIDSinfected patient 51877 examples a few days ago, and number of the infected rises to national second.At present, on average approximately there are 30 people's aids infection viruses in Guangxi every day, and the situation is tense for anti-Chinese mugwort.Difference due to regional culture background and life style and customs, schooling is low, some patients are difficult to accept conventional therapeutic modality, this just requires the treatment of acquired immune deficiency syndrome (AIDS) must take into account all kinds of crowds in different society culture background, after expert group's research, the modal two kinds of pattern of syndrome qi-deficiency types of Guangxi HIV sufferers and damp-heat type, therefore, necessary according to < < Treating AIDS with Traditional Chinese Medicine clinical technology scheme (trying) the > > of the tcm clinical practice feature of Guangxi acquired immune deficiency syndrome (AIDS) and State Administration of Traditional Chinese Medicine's formulation, climate characteristic in conjunction with Guangxi, constitutive character, environmental factors, the factors such as staff condition, a kind of medicine that adapts to the most of infection populations in Guangxi of innovation and creation.

Summary of the invention

Object of the present invention is exactly for the modal two kinds of pattern of syndrome qi-deficiency types of Guangxi HIV sufferers and damp-heat type, in conjunction with factors such as the climate characteristic in Guangxi, constitutive character, environmental factors, staff conditions, provide Chinese medicine preparation of a kind of inhibition HIV (human immunodeficiency virus) that adapts to the most of HIV (human immunodeficiency virus) infection crowds in Guangxi and preparation method thereof.

The present invention is achieved in that

The present invention suppresses the Chinese medicine preparation of HIV (human immunodeficiency virus), it is characterized in that: this Chinese medicine preparation is to be made by the raw material of Chinese medicine of following parts by weight:

Radix Astragali 10-30;

Rhizoma Atractylodis Macrocephalae 5-15;

Radix Paeoniae Alba 5-15;

Radix Codonopsis 5-15;

Radix Rehmanniae Preparata 5-15;

Fructus Lycii 5-15;

Fructus Corni 5-15;

Fructus Psoraleae 5-15;

Radix Ophiopogonis 5-15;

Ganoderma 10-20;

Placenta Hominis 5-15;

Gecko 15-30;

Ramulus Cinnamomi 5-15;

Fructus Jujubae 5-15.

The HIV-1 carrying capacity of the Chinese medicine preparation of above-mentioned inhibition HIV (human immunodeficiency virus) in can patient body becomes stable, can suppress HIV-1 virus, and safe and reliable, do not take the toxic and side effects that similar Western medicine causes.Its price only reaches 1/10 of similar Western medicine.The achievement that this institute is obtained, using the adjuvant drug as AIDS virus resisting.

Each medicine active ingredient of the Chinese medicine formula of the Chinese medicine preparation of above-described inhibition HIV (human immunodeficiency virus) is analyzed:

The Radix Astragali: have another name called: Radix Astragali, wear crushed grain, wear mulberry, solely mulberry, water caltrop grass, another name for Sichuan Province fat, hundred, Rhizoma Paridis tetraphyllae, continuous stilbene, the continuous Radix Astragali, be the general designation of plant and Chinese crude drug.Latin Astragalusmembranaceus (Fisch.) Bunge, English name: Astragalus Membranaceus is leguminous plant Radix Astagali Astragalus membranaceus Bge. var.mongholicus(Bge.) root of Hsiao, invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema Radix Astragali disk, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.For deficiency of spleen-QI and stomach-QI; Deficiency of spleen-QI, sinking of QI of middle-JIAO, visceroptosis (proctoptosis, uterine prolapse, gastroptosis etc.); Insufficiency of lung-QI, cough with asthma is losed heart; Spontaneous sweating due to deficiency of QI, is easy to flu; Deficiency of vital energy edema, dysuria; Insufficiency of vital energy and blood, anemia is sallow, or numb limbs and tense tendons, or skin infection, creation are difficult for healing; Quench one's thirst (diabetes).

The Rhizoma Atractylodis Macrocephalae: another name: Rhizoma Atractylodis Macrocephalae, winter art, the winter Rhizoma Atractylodis Macrocephalae, Latin Rhizoma Atractylodis Macrocephalae, English by name Largehead Atractylodes Rh, the effects such as the Rhizoma Atractylodis Macrocephalae has the gastrointestinal motility of adjustment function, antiulcer, protects the liver, enhancing human body immunity function, anti-stress, enhancing hemopoietic function, antioxidation, slow down aging, blood sugar lowering, anticoagulation, antitumor.< < medicine origin > > records: " dehumidifying benefit is dry, and middle QI invigorating, and warming middle-JIAO goes to wet in taste, and except gastric heat, strong taste, enter diet, quench the thirst, antiabortive." modern pharmacological research confirmation, Rhizoma Atractylodis Macrocephalae decocting liquid has the effect of the HIV (human immunodeficiency virus) of inhibition.

The Radix Paeoniae Alba: latin name: Radix Paeoniae Alba, different name gold Radix Paeoniae, English name White Paeony Root, is Ranunculaceae Paeonia plant.There is antibacterial action.For nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.1. < < herbal classic > >: " main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." 2. < < does not record > >: " clear and coherent blood vessels, in delaying, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder, intestine and small intestine, subduing inflammation, row cold and heat when (controlling), attacked by pestiferous factors stomachache, lumbago." 3. < < property of medicine opinion > >: " controls pathogen of the lung gas Fu Zhong Xu pain, and vim and vigour are gathered, and logical a surname's internal organs are gathered around gas, control evil pain deteriorated blood, disease bone heat when main, strong the five internal organs, the kidney invigorating gas, control trusted subordinate's heavily fortified point swollen, married woman's blood closes obstructed, and repercussive blood can lose pus ".

Radix Codonopsis: another name: Shangdang Radix Ginseng, Radix Saposhnikoviae Radix Codonopsis, Sphallerocarpus gracilis, preventing lanceolata, upper Radix Codonopsis, SHITOUSEN, middle Ganoderma, yellow party, Codonopsis plant, campanulaceae, English name: Root of Pilose Asiabell, Pilose Asiabell Root Moderate Asiabell Root Szechwon Tangshen Root, Latin formal name used at school: Root of Pilose Asiabell, meridian distribution of property and flavor: property is flat, sweet in the mouth, micro-acid.Return spleen, lung meridian.There is invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.Cure mainly weakness of the spleen and stomach, anorexia and loose stool, fatigue and weakness, the deficiency of the lung is breathed with cough, the lazy speech of breathing hard, spontaneous perspiration, blood deficiency and yellow complexion, thirsty.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc.< < Bencao Congxin > > records: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.A little less than middle feeble QI, in order to adjust, mend, very smooth and proper.”

Radix Rehmanniae Preparata: have another name called Radix Rehmanniae Preparata or throw oneself on the ground, belong to goatweed, Scrophulariaceae, English name: Prepared rhizome of Adhesive Rehmannia Latin literary fame: Radix Rehmanniae Preparata. Latin plant animal mineral name: Rehmannia glutinosa (Gaertn.) the Libosch EX Fisch.et Mey.[property of medicine] sweet, tepor.Return liver, kidney channel.[effect] yin nourishing of enriching blood, life essence-filling, marrow-benefitting.Cure mainly: blood tiger is sallow; Dizzy cardiopalmus; Menoxenia; Collapse more than; Hepatic and renal YIN deficiency; Hectic fever night sweat; Seminal emission sexual impotence; Infertility; Soreness of the waist and knees; Hiccough and deaf; The head is dim-sighted; Early whitening of beard and hair; Quench one's thirst; Constipation; The dyspnea with rapid and short breath of suffering from a deficiency of the kidney.

Fructus Lycii: another name: der Bockdorn, the young thorn of red pearl, the right power of cattle, Canis familiaris L. serratd edge, it is the multi-branched shrub plant of Solanaceae Lycium, English name Barbary Wolfberry Fruit, Latin formal name used at school is Lycium chinense, there is the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.

Fructus Corni: another name: Fructus Corni, medicine Fructus Jujubae, Fructus Corni, another name for Sichuan Province Ziziphi Spinosae, meat Fructus Jujubae, potato Fructus Jujubae, chicken foot, real Fructus Jujubae, Fructus Corni, medicine Fructus Jujubae, day wooden seed, Fructus Corni, real Fructus Jujubae, English name: Medical Dogwood, Latin formal name used at school: Cornus officinalis, Cornaceae machaka or dungarunga, meridian distribution of property and flavor: sour, puckery, tepor, returns liver, kidney channel; Function cures mainly: function: liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating, controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping only collapses, hidroschesis, promoting the production of body fluid to quench thirst; For soreness of waist and knee joint, dizziness and tinnitus, forgetful, emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses menoxenia, profuse sweating collapse, interior-heat, quench one's thirst.

Fructus Psoraleae: another name: Fructus Psoraleae, bone fat, Fructus Psoraleae, therefore fat, therefore son, therefore it, Semen Oroxyli, bosom Fructus Psoraleae, broken event fat, Fructus Psoraleae, Fructus Psoraleae, broken frame, the solid fat of mother-in-law, Psoralen sparrow hawk, FRUCTUS PSORALEAE, black Semen Oroxyli, recklessly Fructus Psoraleae, recklessly Semen Allii Tuberosi, lucky solid son, and blue Herba Amaranthi tricoloris, Gu son, Gu fat, river Fructus Psoraleae, lucky Fructus Psoraleae, broken solid fat, recklessly Semen Allii Tuberosi; Leguminous plant; English name: Malaytea Scurfpea Fruit, Fruit of Malaytea Scurfpea Latin plant animal mineral name: Psoralea corylifolia L. nature and flavor: acrid in the mouth, hardship, warm in nature; Effect: reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha; Function cures mainly: reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Impotence and seminal emission; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; Stool chronic diarrhea; Vitiligo; Speckle is bald; Psoriasis.

Radix Ophiopogonis: have another name called Radix Ophiopogonis, dwarf lilyturf, book band grass; Liliaceae Ophiopogon perennial evergreen herbaceous plant; Latin formal name used at school: O.japonicus(L. f.) Ker-Gawl., meridian distribution of property and flavor: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.Effect 1. replenishing YIN and removing heat treatment yin asthenia generating intrinsic heat or the sick impairment of body fluid of calentura, restlessness and thirst.2. thick, the QI rising in reverse order of cough, the expectorant due to nourishing the lung to arrest cough treatment dryness-heat impairing the lung.Function cures mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, quenches one's thirst, calentura Tianjin wound, dry mouth and throat, constipation.

Ganoderma: this product is On Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst., Latin Ganoderma lucidum (Legss.ex Fr.) Karst. or Ganoderma Ganoderma sinense Zhao, the dry sporophore of Xust Zhang.Ganoderma just has the title of " Herba mesonae chinensis ", " Ganoderma " from ancient times, is the precious Chinese medicine of traditional Chinese medical science strengthening the body resistance, strengthening by means of tonics, in China, has long medicinal history, and medical value is high, is regarded as precious Chinese crude drug, is the treasure in pools of traditional Chinese medicine.The < < of Eastern Han Dynasty Sheng Nong's herbal classic > > classifies Ganoderma as top grade, thinks " food, makes light of one's life by commiting suicide not old for a long time, and angle prolongs life ".Modern medicine proves: Ganoderma contains several physiological active substances, can regulate and strengthen body immunity.Current research shows, Ganoderma also has resisting fatigue, looks improving and the skin nourishing, slow down aging and prevents and treats the effects such as acquired immune deficiency syndrome (AIDS).Ganoderan is one of effective ingredient in Ganoderma, is the main component that improves body immunity function of a specified duration, strengthening the body resistance in Ganoderma.The multiple pharmacologically active of Ganoderma is mostly relevant with ganoderan, has isolated at present kind more than 200.Present known ganoderan has pharmacologically active widely, can improve body immunity and human body hypoxia-bearing capability, eliminates free radical, suppress tumor, anti-radiation, improves liver, bone marrow, blood synthetic DNA, RNA and protein ability, life lengthening etc., ganoderan is water-soluble components.

Placenta Hominis: Latin Placenta Hominis, English name Human Placenta, another name: Placenta Hominis, afterbirth, afterbirth, afterbirth, plancenta hominis, Jing Heche, Du Heche.There is tonification, QI invigorating, nourish blood, benefit essence.Be used for controlling deficient, weakness and emaciation, consumptive fever hectic fever due to YIN-deficiency, cough with asthma, spitting of blood, night sweat, seminal emission, sexual impotence, women's vim and vigour are not enough, infertile or newborn few.

Gecko: claim again clam solution, clam Eriocheir sinensis, gecko, celestial toad, Taiwan is called large Gekko Swinhonis, Latin title: Gekko gecko, Gekkonidae, terrestrial reptile, English name Tokay, is mainly distributed near the subtropical zone of the Asia tropic of cancer, comprise China, Vietnam, Thailand and Laos, there is kidney tonifying tonifying the lung; Dingchuan antitussive effect, < < detailed outline > >: former times people's words drugs with tonic function being used for the debility, the genus of Radix Ginseng, Carnis caprae seu ovis.Gecko tonifying the lung gas, Dingchuan is quenched the thirst, the same Radix Ginseng of merit, tonifying YIN blood, helps essence to hold up thin, the same Carnis caprae seu ovis of merit.A little less than controlling strain flaccidity modern times, Xu Shuwei is controlled and is quenched one's thirst, and all uses it, all gets its nourishing also.Liu Chunyun, gas-liquid declines, cloudy Sanguis Draxonis person should use it.What great Ying cloud, Dingchuan antitussive, Mo Jia is in this.< < Bencao Jingshu > >: Gecko, its main lung impairment and cough of a specified duration, pouring drop person, all lung kidney is disease, the labor utmost point lung is suffered from a deficiency of the kidney and heat-dissipating, therefore exopathogen is easily invaded, internal evidence is held concurrently and is sent out also.It is cloudy that Gecko belongs to, can moisturizing on source, lung kidney all institute is supported, and consumptive fever is coughed and is certainly removed; The convergence of vessels in the lung, regulating fluid apssage, lower defeated bladder, normal lung-QI, therefore drench dewatering road from leading to also.< < Haiyao Bencao, Oversea Materia Medica > >: treat injured, gas in main consumptive lung disease, spitting of blood cough.< < Japan hanako materia medica > >: control lung qi, antitussive, and logical menstruation, lower stranguria caused by urinary stone and control blood.< < Kaibao Bencao > >: main impairment of the lung caused by overstrain of a specified duration, treat cough, lower pouring drop, waterway.< < Amplification on Materia Medica > >: tonifying the lung asthenia is coughed.Through the inventor, study discovery, Gecko, in preparation of the present invention, has certain effect to the function of protection internal organs.

Ramulus Cinnamomi: another name: Liu Gui, RAMULUS CINNAMOMI; For Lauraceae aiphyllium plant; English name: Cassia Twig, Latin literary fame: Ramulus Cinnamomi [meridian distribution of property and flavor] acrid, sweet, warm.GUIXIN, lung, urinary bladder channel (diaphoresis power is weak).[function cures mainly] diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Fructus Jujubae: [another name] Fructus Jujubae, Fructus Jujubae, Chinese date, dry Fructus Jujubae, U.S. Fructus Jujubae, good Fructus Jujubae (< < does not record > >), Fructus Jujubae (< < Elementary Medicine > >); [Latin] Chaenomeles sinensis, the fruit of Rhamnaceae xylophyta Fructus Jujubae; In the China's plantation of existing more than 8,000 year history, be just listed in since ancient times one of " five fruits " (Fructus Persicae, Lee, prunus mume (sieb.) sieb.et zucc., Fructus Pruni, Fructus Jujubae); The nutritional labelings such as Fructus Jujubae rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, ferrum and cyclic adenosine monophosphate.Wherein ascorbic content comes out at the top in fruit, has vitamin king's laudatory title.The modern pharmacological research of Fructus Jujubae shows that tool increases the effect of the cAMP in leukocyte, has antiallergic action, protects the liver, increases the effect of muscular strength, calmness, hypnosis and blood pressure lowering.These are all conducive to life lengthening; Jujube polysaccharide is active substance important in Fructus Jujubae, and it has obvious complement activity and promotes Proliferation of lymphocytes, can improve immunity of organisms.Nature and flavor: fruit is sweet, temperature; Return spleen, stomach warp; For weakness of the spleen and stomach, deficiency of QI in middle-JIAO, fatigue and lack of strength, anorexia and loose stool; Blood deficiency fistula is yellow, become thin, or women is dirty dry, and spirit is uneasy.

The Chinese medicine preparation of the invention described above inhibition HIV (human immunodeficiency virus) adds taste by strengthening the body resistance side and is become, the Rhizoma Atractylodis Macrocephalae, and bitter, sweet, temperature, has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis effect.Modern pharmacological research confirmation, the Rhizoma Atractylodis Macrocephalae has the effect of the HIV (human immunodeficiency virus) of inhibition.Other Chinese medicine plays effects such as improving immunity, opposing virus, protection internal organs, comprehensively plays to suppress virus and contaminate body, and dissipating blood stasis for subsidence of swelling, goes the aspects effects such as empty nourishing YIN, mutual aid anti-stress, strengthens the functions such as hemopoietic function.

The Chinese medicine preparation of inhibition HIV (human immunodeficiency virus) of the present invention, by the conventional formulation technique of relevant dosage form, adds appropriate amount of auxiliary materials to make corresponding dosage form, and above-mentioned Chinese medicine preparation can be made oral liquid, granule, capsule, tablet or other pharmaceutically useful dosage form.

The production method of the oral liquid of above-described inhibition HIV (human immunodeficiency virus) is: get by weight ratio the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Codonopsis, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Corni, Fructus Psoraleae, Radix Ophiopogonis, Ganoderma, Placenta Hominis, Ramulus Cinnamomi, Fructus Jujubae and Gecko 14 tastes, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filter, add adjuvant, make oral liquid.

The production method of the granule of above-described inhibition HIV (human immunodeficiency virus), capsule, tablet is: get by weight ratio the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Codonopsis, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Corni, Fructus Psoraleae, Radix Ophiopogonis, Ganoderma, Placenta Hominis, Ramulus Cinnamomi, Fructus Jujubae 13 tastes, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filter, be concentrated into relative density and be 1.30 thick paste, following dry at 80 ℃ again, be ground into fine powder, add and grind to form fine powder sterilized Gecko powder, add adjuvant, mix, granulation agent, capsule or tablet.

The Chinese medicine preparation of above-described inhibition HIV (human immunodeficiency virus) can with the coupling of antiviral Western medicine, the application as treatment in AIDS-treating medicine.

The Chinese medicine preparation of above-described inhibition HIV (human immunodeficiency virus) is tentatively on probation in clinical treatment acquired immune deficiency syndrome (AIDS) project, and reflection is good, without obvious toxic-side effects.

Specific embodiment

Embodiment 1

Getting 10 parts of the Radixs Astragali, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of the Radix Paeoniae Albas, 5 parts of Radix Codonopsis, 5 parts, Radix Rehmanniae Preparata, 5 parts of Fructus Lyciis, 5 parts of Fructus Corni, 5 parts of Fructus Psoraleaes, 5 parts of Radix Ophiopogonis, 10 parts of Ganodermas, 5 parts of Placenta Hominiss, 5 parts of Ramulus Cinnamomi, 5 part of 13 taste of Fructus Jujubae adds water 5-8 by gross weight and doubly decocts secondary, each 2 hours, collecting decoction, filters, and is concentrated into relative density and is 1.30 thick paste, following dry at 80 ℃ again, be ground into fine powder, add and grind to form 15 parts, fine powder sterilized Gecko powder, add adjuvant, mix, make capsule.

Embodiment 2

Getting 12 parts of the Radixs Astragali, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of the Radix Paeoniae Albas, 8 parts of Radix Codonopsis, 8 parts, Radix Rehmanniae Preparata, 10 parts of Fructus Lyciis, 10 parts of Fructus Corni, 10 parts of Fructus Psoraleaes, 10 parts of Radix Ophiopogonis, 15 parts of Ganodermas, 10 parts of Placenta Hominiss, 10 parts of Ramulus Cinnamomi, 10 parts, Fructus Jujubae and Gecko 14 tastes adds water 5-8 by gross weight and doubly decocts with water secondary, each 2 hours, collecting decoction, filter, add adjuvant, make oral liquid.

Embodiment 3

Getting 15 parts of the Radixs Astragali, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Codonopsis, 10 parts, Radix Rehmanniae Preparata, 10 parts of Fructus Lyciis, 10 parts of Fructus Corni, 10 parts of Fructus Psoraleaes, 10 parts of Radix Ophiopogonis, 15 parts of Ganodermas, 10 parts of Placenta Hominiss, 10 parts of Ramulus Cinnamomi, 10 part of 13 taste of Fructus Jujubae adds water 5-8 by gross weight and doubly decocts with water secondary, each 2 hours, collecting decoction, filter, be concentrated into relative density and be 1.30 thick paste, following dry at 80 ℃ again, be ground into fine powder, add and grind to form 25 parts, fine powder sterilized Gecko powder, add adjuvant, mix, make tablet.

Embodiment 4

Getting 30 parts of the Radixs Astragali, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of the Radix Paeoniae Albas, 15 parts of Radix Codonopsis, 15 parts, Radix Rehmanniae Preparata, 15 parts of Fructus Lyciis, 15 parts of Fructus Corni, 15 parts of Fructus Psoraleaes, 15 parts of Radix Ophiopogonis, 20 parts of Ganodermas, 15 parts of Placenta Hominiss, 15 parts of Ramulus Cinnamomi, 15 part of 13 taste of Fructus Jujubae adds water 5-8 by gross weight and doubly decocts with water secondary, each 2 hours, collecting decoction, filter, be concentrated into relative density and be 1.30 thick paste, following dry at 80 ℃ again, be ground into fine powder, add and grind to form 30 parts, fine powder sterilized Gecko powder, add adjuvant, mix granulation agent.

clinical trial data

The present invention's 20 examples offer Guangxi provincial hospital, and to carry out antiviral therapy treatment situation as follows.

One, clinical observation:

1. preparation for treating acquired immune deficiency syndrome (AIDS) clinical symptoms of the present invention, sign situation of change (table 1):

Tcm clinical practice symptom, sign situation of change before and after this compound treatment of table 1

2. preparation for treating acquired immune deficiency syndrome (AIDS) Carlow Paderewski integration situation of change of the present invention (table 2):

Carlow Paderewski integration situation of change before and after table 2 preparation for treating of the present invention

3. preparation for treating acquired immune deficiency syndrome (AIDS) CD4 situation of change of the present invention (table 3):

CD4 situation of change (individual/μ l) before and after table 3 preparation for treating of the present invention

Two, model case:

Case 1:

AIDSinfected patient Lee, company clerk, when within 2004, there is erythra, primary dcreening operation HIV is positive, makes a definite diagnosis HIV infect by confirmatory test.Survey at that time cd4 cell and be counted as 529, body weight is 55kg, start to occur inappetence in August, 2008, dyspepsia, spirit is poor, become thin, weak, spontaneous perspiration, easy catching a cold, 10 times every year on average, diarrhoea, average every day 5 times, watery stool, time have a fear of cold, acid regurgitation, vomiting watery fluid, deep pulse is unable, pale tongue with white fur, from taking diarrhea, have no improvement, then hospital admission, survey cd4 cell and be counted as 302, body weight is 45kg, the traditional Chinese medical science is examined as having loose bowels, syndrome of yang deficiency of spleen and kidney, give this prescription and add Fructus Psoraleae 20g, Semen Myristicae 15g, Fructus Schisandrae Chinensis 15, Fructus Corni 20g, treat altogether after 1 month, patient's appetite is greatly improved, spirit takes a turn for the better, from perspiration stopped, symptom of diarrhea is clearly better, defecate 2 average every day, embark on journey, body weight 52kg, take a good rest, adhere to suitable exercise.Follow up a case by regular visits to in August, 2011, patient catches a cold 3 times every year on average, occasionally has diarrhoea, surveys cd4 cell and is counted as 459.

Case 2

AIDSinfected patient Zhang, driver, in calendar year 2001 start injection drug abuse, will inject 3 times when frequent for 1 day, has repeatedly with other people shared syringe to be, and when Yin Gaore will be in hospital in the end of the year 2006, primary dcreening operation HIV is positive, is diagnosed as HIV infects by Guangxi District CDC confirmatory test.Survey at that time cd4 cell and be counted as 568, start to occur becoming thin in February, 2010, weak, spontaneous perspiration, easy catching a cold, on average monthly 1 time, clear urine in large amounts, sexual impotence, premature ejaculation, can not normally carry out sexual life, time have a fear of cold, time have an acid regurgitation, vomiting watery fluid, deep-slow pulse is unable, pale tongue with white fur, from taking Western medicine, have no improvement, Sui Laiwo center is medical, survey cd4 cell and be counted as 216, the traditional Chinese medical science is examined as sexual impotence, syndrome of yang deficiency of spleen and kidney, give this prescription and add Rhizoma Zingiberis 20g, Actinolitum 15g, Herba Epimedii 15g, Fructus Cnidii 15g, Rhizoma Polygonati 10g, Radix Rehmanniae Preparata 10g, give doctor trained in Western medicine HAART treatment simultaneously, during treatment, have no obvious toxic-side effects, treat altogether after three months, patient's appetite is greatly improved, spirit takes a turn for the better, from perspiration stopped, sexual impotence symptom is clearly better, can normally have sexual intercourse, look steadily it and adhere to taking antiviral drugs, take a good rest, adhere to suitable exercise.Follow up a case by regular visits to in June, 2011, patient catches a cold, and surveys cd4 cell and is counted as 405.

clinical conclusion

Chinese medicine preparation of the present invention is in the first half of the year in 2011 and antiviral combination application, clinical effectiveness shows, Chinese medicine preparation of the present invention and antiviral Western medicine use in conjunction are after 6 months, except myalgia and menoxenia, other symptom and signs all improve significantly, wherein, weak, indigestion and loss of appetite, breathe hard and the curative effect of lumbago is better than using merely antiviral agents, to the curative effect of other symptom and signs with simple by antiviral agents there are no significant difference.The effect that the Chinese medicine preparation of inhibition HIV (human immunodeficiency virus) of the present invention is described is better than simple Western medicine antiviral therapy.

In sum, the Chinese medicine preparation of inhibition HIV (human immunodeficiency virus) of the present invention has the effect that improves AIDS related complex shape sign, that Chinese medicine and antiviral combination improve is weak, indigestion and loss of appetite, breathe hard and the effect of lumbago is better than applying merely antiviral agents, and with antiviral agents use in conjunction without obvious untoward reaction.

Claims (5)

1. a Chinese medicine preparation that suppresses HIV (human immunodeficiency virus), is characterized in that: this Chinese medicine preparation is to be made by the raw material of Chinese medicine of following parts by weight: Radix Astragali 10-30, Rhizoma Atractylodis Macrocephalae 5-15, Radix Paeoniae Alba 5-15, Radix Codonopsis 5-15, Radix Rehmanniae Preparata 5-15, Fructus Lycii 5-15, Fructus Corni 5-15, Fructus Psoraleae 5-15, Radix Ophiopogonis 5-15, Ganoderma 10-20, Placenta Hominis 5-15, Gecko 15-30, Ramulus Cinnamomi 5-15, Fructus Jujubae 5-15.

2. according to the Chinese medicine preparation of the inhibition HIV (human immunodeficiency virus) described in claim l, it is characterized in that: described Chinese medicine preparation is oral liquid, granule, capsule or tablet.

3. according to the production method of the Chinese medicine preparation of the above-described inhibition HIV (human immunodeficiency virus) of claim 1, it is characterized in that: get by weight ratio the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Codonopsis, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Corni, Fructus Psoraleae, Radix Ophiopogonis, Ganoderma, Placenta Hominis, Ramulus Cinnamomi, Fructus Jujubae and Gecko 14 tastes, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filter, add adjuvant, make oral liquid.

4. according to the production method of the Chinese medicine preparation of the above-described inhibition HIV (human immunodeficiency virus) of claim 1, it is characterized in that: get by weight ratio the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Codonopsis, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Corni, Fructus Psoraleae, Radix Ophiopogonis, Ganoderma, Placenta Hominis, Ramulus Cinnamomi, Fructus Jujubae 13 tastes, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filter, be concentrated into relative density and be 1.30 thick paste, following dry at 80 ℃ again, be ground into fine powder, add and grind to form fine powder sterilized Gecko powder, add adjuvant, mix, make capsule.

5. Chinese medicine preparation claimed in claim 1 suppresses the application in HIV (human immunodeficiency virus) medicine in preparation.