CN101428113A - Traditional Chinese medicine preparation for treating type II diabetes and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating type II diabetes and preparation method thereof Download PDFInfo
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- CN101428113A CN101428113A CNA2008100166181A CN200810016618A CN101428113A CN 101428113 A CN101428113 A CN 101428113A CN A2008100166181 A CNA2008100166181 A CN A2008100166181A CN 200810016618 A CN200810016618 A CN 200810016618A CN 101428113 A CN101428113 A CN 101428113A
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating type-2 diabetes, and the traditional Chinese medicine preparation is prepared by the following raw materials according to the mixture ratio by weight: 10-20 parts of radix salviae albae, 10-15 parts of membranous milkvetch root, 10-15 parts of dried rehmannia root, 6-12 parts of barbary wolfberry fruit, 10-15 parts of Mongolian snakegourd root, 5-10 parts of common anemarrhena rhizome, 5-10 parts of kudzuvine root and 1-2 parts of liquoric root. In addition to a certain hypoglycemic effect, the traditional Chinese medicine preparation can significantly improve the type-2 diabetes, in particular to the symptoms of dry mouth and throat, malaise, fatigue, soreness and weakness of waist and knees, burning heat, insomnia, blurred vision, dizziness, heart palpitations, limb numbness and pain, and the like of patients with deficiency of both qi and yin and the blood stasis type diabetes. The greatest feature of the traditional Chinese medicine preparation to be different from the existing technologies is that the radix salviae albae which is the special local herbal medicine in Shandong is firstly applied in the formula for treating the diabetes, thereby effectively improving the clinical treatment effect.
Description
Technical field
The present invention is a field of pharmaceutical technology, relates to a kind of Chinese medicine preparation for the treatment of type 2 diabetes mellitus and preparation method thereof.
Background technology
Since the eighties in 20th century, the whole world and China patient of diabetes patient digital display work increase, and diabetes have become global serious public health problem, and are huge to health of people harm, caused massive losses for the labour force of developing country.IDF (IDF) latest data shows that just have 1 diabetics death per 10 seconds in the global range, and 2 people are diagnosed as the New Development diabetes, and the whole world had 2.46 hundred million people to suffer from diabetes approximately in 2007, and wherein 46% is 40-59 year labour force population.China in 2002 18 years old and above resident's diabetes prevalence are 2.6%, and the impaired fasting glucose (IFG) rate is 1.9%.Estimate the existing number of patients more than 2,000 ten thousand of national diabetes, wherein the type 2 diabetes mellitus people accounts for 95%, and other has nearly 2,000 ten thousand people's impaired fasting glucose (IFG), and the ill crowd trend that becomes younger, the health that directly threatens young and middle-aged people.Diabetes have become the third-largest killer who threatens the human life after tumor and cardiovascular disease.Because of diabetes are chronic, systemic diseases, if state of an illness control is bad, then changeable, can cause multiple acute and chronic complication, and acute and chronic complication to be diabetics disable lethal principal element.
At present, diabetes also can't be cured.Clinically integrated approach such as diet, motion, medicine that adopt are treated more, and target is blood sugar control, improves islet function, relief of symptoms, delay and prevent and treat complication.Wherein Diet Therapy is the basis, and Drug therapy is crucial.In Drug therapy, mainly by Western medicine, as sulphanylureas, biguanides etc., the problem of existence is: effect is single for blood sugar control, and drug side effect is big.Though Chinese medicine has certain blood sugar reducing function, effect is limited, about the Chinese medicine preparation of treatment diabetes, and existing multiple patent application in the prior art, its prescription has nothing in common with each other, and therapeutic effect also has nothing in common with each other.
Summary of the invention
The object of the present invention is to provide a kind of prior art that is different from, to type 2 diabetes mellitus therapeutic effect Chinese medicine preparation preferably.
Another object of the present invention is to provide the preparation method of this Chinese medicine preparation.
The present invention is achieved in that a kind of Chinese medicine preparation for the treatment of type 2 diabetes mellitus, is mainly made by the following weight proportion raw material: Salvia miltiorrhiza f. 10～20, the Radix Astragali 10～15, the Radix Rehmanniae 10～15, Fructus Lycii 6～12, Radix Trichosanthis 10～15, the Rhizoma Anemarrhenae 5～10, Radix Puerariae 5～10, Radix Glycyrrhizae 1～2.
Preparation method as the above-mentioned Chinese medicine preparation of the present invention comprises the following steps:
1. take by weighing above-mentioned 8 flavor Chinese herbal medicine by weight percentage;
2. decoct with water 3 times, the time was respectively 2～3,1.5～2,1～1.5 hours, and collecting decoction filters;
3. filtrate is left standstill cold preservation (4～7 ℃) filtered in 24 hours;
4. filtrate decompression is concentrated the thick paste that (65～70 ℃ of temperature) becomes relative density 1:1.2～1.3;
5. with thick paste with low-temperature vacuum drying method drying (60～70 ℃ of temperature);
6. the dried piece that drying is obtained pulverize, granulate, radiation irradiation sterilization (quality inspection);
7. use the filling machine fill, every bag of 3g, pack (quality inspection), dress box, vanning, warehouse-in.
As a further improvement on the present invention, its raw material also has: Radix Ginseng 5～10, Radix Ophiopogonis 6～12, Semen Cuscutae 6～12, Fructus Mume 6～12.
Further improve as the present invention, its raw material also has: Semen Cassiae 5～15, Fructus Crataegi 5～15.
The performance of each raw material of the present invention:
Salvia miltiorrhiza f.: hardship is slightly cold.GUIXIN, Liver Channel.Have blood circulation promoting and blood stasis dispelling, effect such as the relieving restlessness that clears away heart-fire.Salvia miltiorrhiza f. is the superfine product in the Radix Salviae Miltiorrhizae family, studies show that, its contained TANSHINONES, danshensu all are 2-3 times of pale reddish brown Radix Salviae Miltiorrhizae, and myocardial ischemia, hyperlipidemia, hypertension, atherosclerosis etc. are had significant curative effect; The Salvia miltiorrhiza f. water extract can improve hyperlipidemia rats blood fat and blood glucose situation.This kind medical material is the local characteristic medical material of applicant, for many years, Laiwu City R﹠D institution unites relevant colleges and universities institutes, has carried out a series of researchs from aspects such as species collection, wild domestication, fine-variety breeding, high-yield culturing, pharmacology, drug effect, toxicitys, and has made a breakthrough.2002, the Laiwu Salvia miltiorrhiza f. was listed Shandong Province's genuine medicinal materials in.At present, formed the resources advantage of unique Laiwu characteristic, development prospect is wide.
Radix Ginseng: sweet, little hardship, tepor.GUIXIN, lung, spleen, kidney channel.Have effects such as supplementing QI to prevent collapse, supplementing QI for promoting the production of body fluid.With control consumption of body fluid caused by febrile disease, hyperhidrosis is thirsty, normal and Gypsum Fibrosum, the Rhizoma Anemarrhenae are equal to usefulness; Taking fluids profusely was immoderate due to interior-heat was quenched one's thirst, compatibilities such as normal and Radix Trichosanthis, Radix Ophiopogonis, Radix Puerariae.Pharmacological research shows that Radix Ginseng all has the blood sugar lowering effect to normal Canis familiaris L. and alloxan diabetes dog, has the obvious functions of blood sugar effect to the alloxan diabetes Mus.Clinical research shows, Radix Ginseng treatment diabetes not only can be improved general symptom such as weak, thirsty, weakness etc., and can blood sugar lowering and glucose in urine.Be applicable to light, middle diabetes mellitus type, Chinese medical discrimination is suffered from a deficiency of the kidney, gas deficiency of YIN person better efficacy.
The Radix Astragali: sweet, tepor.Return lung, spleen channel.Have effects such as tonifying Qi and lifting yang, benefiting QI for activating blood circulation.Pharmacological research shows to have myocardial contraction, the diastole coronary vasodilator of reinforcement, bring high blood pressure down, protect effects such as hepatocyte, blood sugar lowering.Treatment diabetes such as the clinical Radix Astragali cooperation drugs for nourishing yin commonly used such as the Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis.
The Radix Rehmanniae: sweet, cold.GUIXIN, liver, kidney channel.Have effects such as clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Studies show that the Radix Rehmanniae has the blood sugar lowering effect, and can suppress experimental hyperglycemia.
Radix Ophiopogonis: sweet, little hardship is slightly cold.GUIXIN, lung, stomach warp.Have effects such as nourishing YIN and moistening the lung, reinforcing stomach reg fluid.Its extract has anti-hypoxia, enhance immunity, blood sugar lowering and lipoid peroxidization resistant.
Fructus Lycii: sweet, flat.Return liver, kidney, lung meridian.Have effects such as beneficial smart the kidney invigorating, nourishing the liver to improve visual acuity.Pharmaceutical research shows that it has effects such as blood sugar lowering, blood pressure lowering and anti-fatty liver, antioxidation.
Radix Trichosanthis: sweet, little hardship is slightly cold.Attach to the lung and stomach meridians.Have heat clearing away, promote the production of body fluid, quench the thirst, pathogenic fire reducing, effect such as moisturize.Be used for the calentura excessive thirst, lung-heat type cough, interior-heat are quenched one's thirst etc.Radix Trichosanthis is joined the Rhizoma Anemarrhenae, nourishing yin and purging fire, promoting the production of body fluid to quench thirst, the excessive thirst of treatment consumption of body fluid caused by febrile disease and the diabetes of exuberant lung-stomach heat impairment of body fluid.
The Rhizoma Anemarrhenae: bitter, sweet, cold.Return lung, stomach, kidney channel.Have clearing away heat-fire, promote the production of body fluid and effect such as moisturize.With controlling interior-heat impairment of body fluid and diabetes.Disease sees thirst and drinking person, compatibilities such as normal and Gypsum Fibrosum, Radix Puerariae, Radix Ophiopogonis.
Radix Puerariae: sweet, hot, cold.Return spleen, stomach warp.Effects such as promoting the production of body fluid to quench thirst are arranged.The flavone that extracts in the Radix Puerariae can increase brain and crown vascular flow, and vascular resistance reduces, and has hypotensive effect.Puerarin can make alloxan diabetes Mus blood glucose obviously descend, and blood sugar reducing function is lasting.
Semen Cuscutae: sweet, warm.Return the liver,kidney,spleen warp.Have effects such as warming the kidney to invigorate YANG, strengthening the tendons and bones.Cure mainly that the muscles and bones flaccidity is soft, lumbago flaccidity of the lower limbs, sexual impotence etc.
Semen Cassiae: sweet, bitter, salty, be slightly cold.Return liver, large intestine channel.Have effects such as clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.This product has the effect that reduces serum cholesterol and blood pressure lowering.Experiment showed, that Semen Cassiae has the effect that cholesterolemia raises and atheromatous plaque forms that suppresses.
Fructus Mume: sour, puckery, flat.Return liver, spleen, lung, large intestine channel.Effect such as have convergence, promote the production of body fluid, quench the thirst.With controlling the interior-heat caused by deficiency of YIN excessive thirst, normal and Radix Trichosanthis, Radix Ophiopogonis, Radix Ginseng are equal to usefulness.
Fructus Crataegi: sour, sweet, tepor.Return spleen, stomach, Liver Channel.Have effects such as promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis.Experiment showed, that this product has obvious effect for reducing blood fat to experimental hyperlipidemia.Can reduce hypercholesterolemiaserum serum T-CHOL, low-density and C-VLDL, improve the serum high-density LP cholesterol.External application may is made various preparations, is used for the treatment of hyperlipemia and coronary heart disease for many years.
Radix Glycyrrhizae: sweet, do.GUIXIN, lung, spleen, stomach warp.Have effects such as QI invigorating invigorating middle warmer, coordinating the actions of various ingredients in a prescription.
[side separate] deficiency of both QI and YIN is a syndrome the most common in the type 2 diabetes mellitus, and the deficiency of both QI and YIN stasis of blood type of holding concurrently is the most common pattern of syndrome of type 2 diabetes mellitus complication, and feature is: 1. the course of disease is longer relatively, is more common in the middle and late stage of diabetes; 2. scorching standard card is moved back, and " more than three " symptom of typical polydipsia, polyuria, polyphagia is not remarkable, merges complication such as blurred vision, dizzy cardiopalmus, limbs fiber crops ache, edema chest pain uncomfortable in chest, apoplectic hemiplegia more; 3. clinical manifestation with xerostomia, weak, breathe hard, enlarged tongue matter secretly is feature.Fully reflected the pathogenic characteristic that deficiency of both QI and YIN is held concurrently stasis of blood type.Answer supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling in the treatment.
The rule of treatment for the treatment of diabetes at all times is always based on nourishing YIN and clearing away heat, kidney and spleen invigorating, supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling.Among the we, Salvia miltiorrhiza f. is effects such as the vital energy regualting and blood circulation-promoting medical instrument has blood circulation promoting and blood stasis dispelling, the relieving restlessness that clears away heart-fire, energy blood fat reducing, blood pressure lowering, blood sugar lowering.Reuse this product, curative effect increases, and is monarch drug; Resistance and supplementing qi medicine Radix Ginseng, the Radix Astragali, the drugs for nourishing yin Radix Rehmanniae, Radix Ophiopogonis, Fructus Lycii, antipyretic Radix Trichosanthis, the Rhizoma Anemarrhenae, Radix Puerariae, the yang-tonifying drug Semen Cuscutae, principal drug assistance nourishing YIN and clearing away heat, kidney and spleen invigorating, supplementing QI and nourishing YIN are ministerial drug altogether; Fructus Mume is restrained, promotes the production of body fluid, is quenched the thirst, and Semen Cassiae clearing away heat to improve acuity of vision, loosening bowel to relieve constipation are adjuvant drug altogether; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is a messenger drug.
The prescription of this preparation can the balance body negative and positive, can play regulating action to internal organs again.We can obviously improve the particularly deficiency of both QI and YIN symptoms such as stasis of blood diabetes mellitus type dryness of the mouth and throat, fatigue and weakness, soreness of the waist and knees, dysphoria with smothery sensation insomnia, blurred vision, dizzy cardiopalmus, limbs fiber crops ache of holding concurrently of type 2 diabetes mellitus except that having certain blood sugar reducing function.The effect that also has blood pressure lowering and blood lipid regulation simultaneously.The present invention's difference has the maximum characteristics of prior art to be, first Shandong special product medical material Salvia miltiorrhiza f. is applied to treat in the prescription of diabetes, has effectively improved clinical therapeutic efficacy.
The advantage of in fact treatment by Chinese herbs diabetes is: alleviate or remove patient's clinical symptoms by the method for determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, prevent and treat multiple chronic complicating diseases, prolong the life-span of diabetics.The agent of this prescription can obviously improve patient's clinical symptoms except that having certain blood sugar reducing function, given full play to the advantage of treatment by Chinese herbs diabetes.
The specific embodiment
Embodiment 1:
A kind of Chinese medicine preparation for the treatment of type 2 diabetes mellitus is made by the following weight proportion raw material: Salvia miltiorrhiza f. 10, the Radix Astragali 10, the Radix Rehmanniae 10, Fructus Lycii 6, Radix Trichosanthis 10, the Rhizoma Anemarrhenae 5, Radix Puerariae 5, Radix Glycyrrhizae 1.
Embodiment 2:
A kind of Chinese medicine preparation for the treatment of type 2 diabetes mellitus is made by the following weight proportion raw material: Salvia miltiorrhiza f. 20, the Radix Astragali 15, the Radix Rehmanniae 15, Fructus Lycii 12, Radix Trichosanthis 15, the Rhizoma Anemarrhenae 10, Radix Puerariae 10, Radix Glycyrrhizae 2.
The preparation method of embodiment 1, embodiment 2 comprises the following steps:
1. take by weighing above-mentioned 8 flavor Chinese herbal medicine by weight percentage;
2. decoct with water 3 times, the time was respectively 2～3,1.5～2,1～1.5 hours, and collecting decoction filters;
3. filtrate is left standstill cold preservation (4～7 ℃) filtered in 24 hours;
4. filtrate decompression is concentrated the thick paste that (65～70 ℃ of temperature) becomes relative density 1:1.2～1.3;
5. with thick paste with low-temperature vacuum drying method drying (60～70 ℃ of temperature);
6. the dried piece that drying is obtained pulverize, granulate, radiation irradiation sterilization (quality inspection);
7. use the filling machine fill, every bag of 3g, pack (quality inspection), dress box, vanning, warehouse-in.
Embodiment 3:
A kind of Chinese medicine preparation for the treatment of type 2 diabetes mellitus is made by the following weight proportion raw material: Salvia miltiorrhiza f. 20, the Radix Astragali 15, the Radix Rehmanniae 15, Fructus Lycii 12, Radix Trichosanthis 15, the Rhizoma Anemarrhenae 10, Radix Puerariae 10, Radix Glycyrrhizae 2, Radix Ginseng 10, Radix Ophiopogonis 12, Semen Cuscutae 12, Fructus Mume 12.
The preparation method of present embodiment may further comprise the steps:
1. take by weighing above-mentioned 12 flavor Chinese herbal medicine by weight percentage;
2. Radix Ginseng is decocted 2 times separately, 45～60 minutes for the first time, 30～45 minutes for the second time, collecting decoction filtered filtrate for later use;
3. Radix Ginseng residue and other 11 flavor Chinese medicines are decocted with water 3 times, the time was respectively 2～3,1.5～2,1～1.5 hours, and collecting decoction filters;
4. will be 2., 3. gained filtrate merges, leave standstill cold preservation (4～7 ℃) and filtered in 24 hours;
5. filtrate decompression is concentrated the thick paste that (65～70 ℃ of temperature) becomes relative density 1:1.2～1.3;
6. with thick paste with low-temperature vacuum drying method drying (60～70 ℃ of temperature);
7. the dried piece that drying is obtained pulverize, granulate, radiation irradiation sterilization (quality inspection);
8. use the filling machine fill, every bag of 3g, pack (quality inspection), dress box, vanning, warehouse-in.
Embodiment 4:
A kind of Chinese medicine preparation for the treatment of type 2 diabetes mellitus is made by the following weight proportion raw material: Salvia miltiorrhiza f. 20, the Radix Astragali 15, the Radix Rehmanniae 15, Fructus Lycii 12, Radix Trichosanthis 15, the Rhizoma Anemarrhenae 10, Radix Puerariae 10, Radix Glycyrrhizae 2, Radix Ginseng 10, Radix Ophiopogonis 12, Semen Cuscutae 12, Fructus Mume 12, Semen Cassiae 15, Fructus Crataegi 15.
The present embodiment preparation method may further comprise the steps:
1. take by weighing above-mentioned 14 flavor Chinese herbal medicine by weight percentage;
2. Radix Ginseng is decocted 2 times separately, 45～60 minutes for the first time, 30～45 minutes for the second time, collecting decoction filtered filtrate for later use;
3. Radix Ginseng residue and other 13 flavor Chinese medicines are decocted with water three times, the time was respectively 2～3,1.5～2,1～1.5 hours, and collecting decoction filters;
4. will be 2., 3. gained filtrate merges, leave standstill cold preservation (4～7 ℃) and filtered in 24 hours;
5. filtrate decompression is concentrated the thick paste that (65～70 ℃ of temperature) becomes relative density 1:1.2～1.3;
6. with thick paste with low-temperature vacuum drying method drying (60～70 ℃ of temperature);
7. the dried piece that drying is obtained pulverize, granulate, radiation irradiation sterilization (quality inspection);
8. use the filling machine fill, every bag of 3g, pack (quality inspection), dress box, vanning, warehouse-in.
The indication of Chinese medicine preparation of the present invention: the suitable deficiency of both QI and YIN stasis of blood type type 2 diabetes mellitus patient that holds concurrently, can blood sugar lowering, obviously improve symptoms such as diabetics dryness of the mouth and throat, fatigue and weakness, soreness of the waist and knees, dysphoria with smothery sensation insomnia.The effect that also has blood pressure lowering and blood lipid regulation simultaneously.Patients whose symptoms were less severe can select embodiment 1 described prescription for use, and the heavier person of symptom can select embodiment 3 described prescriptions for use, if diabetics with hyperlipemia, adds with Semen Cassiae, Fructus Crataegi and can obtain good effect.Merge the blurred vision person, reusable Semen Cassiae can be selected embodiment 4 described prescriptions for use.
The usage of Chinese medicine preparation of the present invention: each 3g, every day 3 times, take 30 minutes ante cibum.The heavier person of symptom, each consumption can increase to 6g.
The clinical treatment case for example
Case one: Liu, the man, 50 years old, Han nationality, Fengcheng City, Laiwu City Laicheng district people from subdistrict office, it is surplus to suffer from diabetes 5 years.
The patient excessive thirst polydipsia (about 3～4 thermos flasks of drinking water every day) occurs because of unknown cause, polyuria (urinating every day about 10～15 times), and polyorexia, weight loss (about 10 kilograms) 3 months institute was gone to a doctor to me in June, 2002, was diagnosed as type 2 diabetes mellitus.Give treatments such as metformin, glipizide.Thereafter, Ceng Yinwei carries out diet, motion and psychotherapy according to the doctor's advice standard, not up to standard and 4 hospitalization of glycemic control.In July, 2005, " more than three " symptom of the typical polydipsia of patient, polyuria, polyphagia is not remarkable, but malaise occurs, breathe hard, the extremity fiber crops are painful, both hands are shaken, and still feel xerostomia.Laboratory examination: FPG14.9mmol/L, glucose in urine (++); Serum total cholesterol (TCh) 7.8mmol/L, serum triglycerides (TG) 3.2mmol/L.Be diagnosed as the concurrent peripheral neuropathy of type 2 diabetes mellitus, hyperlipemia.Give western medicines such as blood sugar lowering, blood fat reducing, trophic nerve, glycemic control is up to standard substantially, but xerostomia, malaise, breathe hard, symptom that extremity fiber crops are painful do not have obvious improvement, rate and blood-lipid decreased is not obvious.Through rounded analysis, patient's symptom meets the hold concurrently clinical characters of stasis of blood type diabetes of deficiency of both QI and YIN, adds the treatment with we then.Treat 10 days (1 course of treatment), symptom is obviously improved, and after 3 courses of treatment, symptom disappears substantially, and blood fat is reduced to normal range.Existing state of an illness control is good.
Case two: make pottery certain, the woman, 53 years old, Han nationality, high village people from subdistrict office in Laiwu City Laicheng district suffered from diabetes 4 years.
The patient institute goes to a doctor to my in March, 2004 because of weak, thirsty, skin pruritus appears in unknown cause, symptom 2 wheat harvesting periods such as become thin, and is diagnosed as type 2 diabetes mellitus.Give treatments such as metformin, glimepiride.Thereafter, Ceng Yinwei carries out diet, motion and psychotherapy according to the doctor's advice standard, not up to standard and 5 hospitalization of glycemic control.In October, 2007, the patient vision occurs and obviously descends suddenly.Check and find the retina of both eyes pathological changes, left eye has 4 of retina tumors, and right eye has retina tumor a plurality of.Survey vision right eye 0.3, left eye 0.5.Vitreum is slightly muddy.Simultaneously with weak, thirsty, cold perspiration, vexed difficulty sleep, symptom such as constipation.Be diagnosed as the concurrent retinopathy of type 2 diabetes mellitus.Give western medicines such as blood sugar lowering, trophic nerve, microcirculation improvement, glycemic control is up to standard substantially, but symptom such as weak, thirsty, blurred vision does not have obvious improvement.Through rounded analysis, patient's symptom meets the hold concurrently clinical characters of stasis of blood type diabetes of deficiency of both QI and YIN, adds the treatment with we then, reuses Semen Cassiae in the side.Treat 10 days (1 course of treatment), symptom is obviously improved, and after 3 courses of treatment, symptom disappears substantially, and patient is in high spirits, falls asleep, and self-induction has strength, and the cold perspiration symptom has also disappeared, and defecation is normal.Survey vision left eye 1.0, right eye 0.8.Existing state of an illness control is good.
Claims (6)
1, a kind of Chinese medicine preparation for the treatment of type 2 diabetes mellitus, it is characterized in that: it is mainly made by the following weight proportion raw material: Salvia miltiorrhiza f. 10～20, the Radix Astragali 10～15, the Radix Rehmanniae 10～15, Fructus Lycii 6～12, Radix Trichosanthis 10～15, the Rhizoma Anemarrhenae 5～10, Radix Puerariae 5～10, Radix Glycyrrhizae 1～2.
2, the Chinese medicine preparation of treatment type 2 diabetes mellitus according to claim 1 is characterized in that: its raw material also has: Radix Ginseng 5～10, Radix Ophiopogonis 6～12, Semen Cuscutae 6～12, Fructus Mume 6～12.
3, the Chinese medicine preparation of treatment type 2 diabetes mellitus according to claim 2 is characterized in that: its raw material also has: Semen Cassiae 5～15, Fructus Crataegi 5～15.
4,, it is characterized in that comprising the following steps: according to the preparation method of the described Chinese medicine preparation of claim 1
1. take by weighing above-mentioned 8 flavor Chinese herbal medicine by weight percentage;
2. decoct with water 3 times, the time was respectively 2～3,1.5～2,1～1.5 hours, and collecting decoction filters;
3. filtrate is left standstill cold preservation (4～7 ℃) filtered in 24 hours;
4. filtrate decompression is concentrated the thick paste that (65～70 ℃ of temperature) becomes relative density 1:1.2～1.3;
5. with thick paste with low-temperature vacuum drying method drying (60～70 ℃ of temperature);
6. the dried piece that drying is obtained pulverize, granulate, radiation irradiation sterilization (quality inspection);
7. use the filling machine fill, every bag of 3g, pack (quality inspection), dress box, vanning, warehouse-in.
5,, it is characterized in that comprising the following steps: according to the preparation method of the described Chinese medicine preparation of claim 2
1. take by weighing above-mentioned 12 flavor Chinese herbal medicine by weight percentage;
2. Radix Ginseng is decocted 2 times separately, 45～60 minutes for the first time, 30～45 minutes for the second time, collecting decoction filtered filtrate for later use;
3. Radix Ginseng residue and other 11 flavor Chinese medicines are decocted with water 3 times, the time was respectively 2～3,1.5～2,1～1.5 hours, and collecting decoction filters;
4. will be 2., 3. gained filtrate merges, leave standstill cold preservation (4～7 ℃) and filtered in 24 hours;
5. filtrate decompression is concentrated the thick paste that (65～70 ℃ of temperature) becomes relative density 1:1.2～1.3;
6. with thick paste with low-temperature vacuum drying method drying (60～70 ℃ of temperature);
7. the dried piece that drying is obtained pulverize, granulate, radiation irradiation sterilization (quality inspection);
8. use the filling machine fill, every bag of 3g, pack (quality inspection), dress box, vanning, warehouse-in.
6,, it is characterized in that comprising the following steps: according to the preparation method of the described Chinese medicine preparation of claim 3
1. take by weighing above-mentioned 14 flavor Chinese herbal medicine by weight percentage;
2. Radix Ginseng is decocted 2 times separately, 45～60 minutes for the first time, 30～45 minutes for the second time, collecting decoction filtered filtrate for later use;
3. Radix Ginseng residue and other 13 flavor Chinese medicines are decocted with water three times, the time was respectively 2～3,1.5～2,1～1.5 hours, and collecting decoction filters;
4. will be 2., 3. gained filtrate merges, leave standstill cold preservation (4～7 ℃) and filtered in 24 hours;
5. filtrate decompression is concentrated the thick paste that (65～70 ℃ of temperature) becomes relative density 1:1.2～1.3;
6. with thick paste with low-temperature vacuum drying method drying (60～70 ℃ of temperature);
7. the dried piece that drying is obtained pulverize, granulate, radiation irradiation sterilization (quality inspection);
8. use the filling machine fill, every bag of 3g, pack (quality inspection), dress box, vanning, warehouse-in.
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| CN105168873A (en) * | 2015-08-14 | 2015-12-23 | 兰为民 | Traditional Chinese medicine composition conditioning diabetes and preparation method therefor |
| CN105434802A (en) * | 2015-12-04 | 2016-03-30 | 陈雪琴 | Pharmaceutical composition for treating diabetes, and preparation method and application thereof |
| CN105535422A (en) * | 2014-10-31 | 2016-05-04 | 康普药业股份有限公司 | Non-insulin-dependent diabetes mellitus treating traditional Chinese medicine and preparation method thereof |
| CN106070820A (en) * | 2016-08-15 | 2016-11-09 | 陈德忠 | A kind of Chinese medicine blood sugar lowering tea |
| CN108159282A (en) * | 2017-12-28 | 2018-06-15 | 漳州开普生物科技有限公司 | A kind of draft nutritional formula treated diabetes and merge liver fibrosis |
| CN108465039A (en) * | 2018-06-28 | 2018-08-31 | 黄建平 | A kind of drug and preparation method thereof for treating diabetes |
| CN113995823A (en) * | 2021-10-29 | 2022-02-01 | 瑞纳康(北京)生物科技有限公司 | Blood sugar-reducing and pancreas-strengthening formula and preparation method thereof |
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2008
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| CN103751558A (en) * | 2014-01-25 | 2014-04-30 | 福建省农业科学院农业生态研究所 | Compound blood glucose reducing pills and preparation method thereof |
| CN105535422A (en) * | 2014-10-31 | 2016-05-04 | 康普药业股份有限公司 | Non-insulin-dependent diabetes mellitus treating traditional Chinese medicine and preparation method thereof |
| CN105168873A (en) * | 2015-08-14 | 2015-12-23 | 兰为民 | Traditional Chinese medicine composition conditioning diabetes and preparation method therefor |
| CN105434802A (en) * | 2015-12-04 | 2016-03-30 | 陈雪琴 | Pharmaceutical composition for treating diabetes, and preparation method and application thereof |
| CN106070820A (en) * | 2016-08-15 | 2016-11-09 | 陈德忠 | A kind of Chinese medicine blood sugar lowering tea |
| CN108159282A (en) * | 2017-12-28 | 2018-06-15 | 漳州开普生物科技有限公司 | A kind of draft nutritional formula treated diabetes and merge liver fibrosis |
| CN108159282B (en) * | 2017-12-28 | 2020-11-17 | 漳州开普生物科技有限公司 | Traditional Chinese medicine composition for treating diabetes complicated with hepatic fibrosis |
| CN108465039A (en) * | 2018-06-28 | 2018-08-31 | 黄建平 | A kind of drug and preparation method thereof for treating diabetes |
| CN113995823A (en) * | 2021-10-29 | 2022-02-01 | 瑞纳康(北京)生物科技有限公司 | Blood sugar-reducing and pancreas-strengthening formula and preparation method thereof |
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