CN101757408A - Medicament for treating lupus erythematosus and preparation method thereof - Google Patents
Medicament for treating lupus erythematosus and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating lupus erythematosus and a preparation method thereof. The medicament is prepared by using subprostrate sophorae, radix astragali, sweet wormwood, radix rehmanniae, radix scrophulariae, buffalo horn, honeysuckle flower, liquorice, sinkiang arnebia root, red flower, lilium brownii, radix asparagi, lucid ganoderma and American ginseng as raw materials, the raw materials are extracted and dried to prepare dry powder, and various preparations can be prepared according to the demands. The medicament of the invention has good treatment effect on the lupus erythematosus, and has functions of strengthening body resistance to consolidate constitution, tonifying the kidney, nourishing the liver, tonifying qi, nourishing the lung, nourishing and suppressing yang, clearing heat, detoxicating, invigorating the blood circulation, removing the blood stasis, diminishing inflammation, relieving the pain and strengthening the immunity.
Description
Technical field
The present invention relates to a kind of Chinese medicine and preparation method thereof, relate in particular to a kind of medicine for the treatment of lupus erythematosus and preparation method thereof.
Background technology
The traditional Chinese medical science is thought: the mechanism of lupus erythematosus morbidity, the factor of inside and outside two aspects is arranged, and interior root is in the internal organs imbalance of YIN and YANG, and is outer because of in pyretic toxicity and damp and hot causing.The name of disease of traditional Chinese medical science ancient books unsystematic lupus erythematosus (SLE), the description of its symptom sporadically appears and sends out speckle etc. in YIN YANG toxin syndrome, butterfly spot, chronic erythematosus, itching eruption due to wind-heat in blood, YANG toxin syndrome, and its internal organs pathological changes then sees edema, in the disease such as deficient, blood disorder obstruction and rejection.As " Medical Treasures of the Golden Chamber " record " YANG toxin syndrome be disease, flushed complexion is full of stains or spots as bright and beautiful stricture of vagina, throat pain, spitting bloody pus." insidious be disease, appearance is clear, general pain as if the patient were suffering a severe beating with sticks, throat pain.It is described and (SIE) erythra arthralgia, and it is hemorrhage generate heat, performances such as oral ulcer very similar " husband desires to debate the YIN YANG toxin syndrome patient, and the beginning can see when falling ill that brothers refer to, cold person is the moon, and not cold person is positive ".The traditional Chinese medical science is thought: " etiology and pathogenesis, the natural endowment deficiency, the hepatic and renal YIN deficiency, or because of internal injury caused by excess of seven emotions, overwork so that the yang blood and qi disequilibrium, the vital organs of the human body are impaired, and QI-blood circulation is not smooth, qi depression to blood stasis, meridians intercept and are the primary disease cause of disease.And the M ﹠ M of lupus erythematosus is progressively rising.
At present, how the treatment of lupus erythematosus is that primary and secondary effect is big with doctor trained in Western medicine, but a large amount of clinical observation proves, therapy of combining Chinese and Western medicine SLE can not only improve also effective prolong remission of symptom, the reduction mortality rate.Adhering to therapy of combining Chinese and Western medicine in the catabasis, is the successful key of primary disease treatment.The compound recipe Radix Gentianae Macrophyllae sheet that China produces is thought eliminating aspect symptom and lupus erythematosus turn out cloudy through clinical practice, is better than Western medicine prednisone matched group.The present domestic treatment policy that has adopted the combination of Chinese and Western medicine, but still do not have comparatively practical and specific Chinese medicine preparation.
Summary of the invention
Technical problem to be solved by this invention provides a kind of medicine for the treatment of lupus erythematosus and preparation method thereof, a kind of new medicine is provided, overcome existing weak point in the above-mentioned prior art, have practicality, have no side effect, and comparatively effectively treat the medicine of lupus erythematosus, and the preparation method of this medicine is provided.
Technical problem to be solved by this invention is achieved through the following technical solutions:
A kind of medicine for the treatment of lupus erythematosus is characterized in that it is the medicament of being made by following materials of weight proportions: Radix Sophorae Tonkinensis 5-11, Radix Astragali 4-9, Herba Artemisiae Annuae 3-9, Radix Rehmanniae 3-9, Radix Scrophulariae 3-9, Cornu Bubali 3-9, Flos Lonicerae 2-8, Radix Glycyrrhizae 1-4, Radix Arnebiae (Radix Lithospermi) 2-8, Flos Carthami 1-4, Bulbus Lilii 2-8, Radix Asparagi 2-7, Ganoderma 1-4, Radix Panacis Quinquefolii 2-7.
The medicine of described treatment lupus erythematosus, wherein the weight proportion of each raw material is: Radix Sophorae Tonkinensis 7-9, Radix Astragali 6-7, Herba Artemisiae Annuae 5-7, Radix Rehmanniae 5-7, Radix Scrophulariae 5-7, Cornu Bubali 5-7, Flos Lonicerae 4-6, Radix Glycyrrhizae 2-3, Radix Arnebiae (Radix Lithospermi) 4-6, Flos Carthami 2-3, Bulbus Lilii 4-6, Radix Asparagi 4-5, Ganoderma 2-3, Radix Panacis Quinquefolii 4-5.
The medicine of described treatment lupus erythematosus, wherein the weight proportion of each raw material is: Radix Sophorae Tonkinensis 8, the Radix Astragali 6.5, Herba Artemisiae Annuae 6, the Radix Rehmanniae 6, Radix Scrophulariae 6, Cornu Bubali 6, Flos Lonicerae 5, Radix Glycyrrhizae 2.5, Radix Arnebiae (Radix Lithospermi) 5, Flos Carthami 2.5, Bulbus Lilii 5, Radix Asparagi 4.7, Ganoderma 2.5, Radix Panacis Quinquefolii 4.5.
Described medicament is powder, unguentum, electuary or capsule.
The preparation method of above-mentioned treatment lupus erythematosus medicine may further comprise the steps:
A. take by weighing each raw medicinal material by weight;
B. Flos Lonicerae, Radix Glycyrrhizae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Asparagi, Bulbus Lilii and Ganoderma are carried out the water distillation, its volatile oil is provided;
C. the solid medicine material after the distillation adds decocting twice, and each amount of water was not advisable to have spice, merged two
Inferior decocting liquid filters to get filtrate, and adds the ethanol of 90%-95% after concentrating, and makes pure content reach 60%-80%, precipitate with ethanol filter pure liquid, reclaim the ethanol reconcentration, concentrate the back and add Extraction oil, 40-46 ° dry down, make dry extract 1;
D. Radix Sophorae Tonkinensis, the Radix Astragali, Herba Artemisiae Annuae, the Radix Rehmanniae, Radix Panacis Quinquefolii, Radix Scrophulariae and Cornu Bubali are added together the ethanol of 90%-95%, carry out reflux, extract,, extracting solution reclaims ethanol, and is dry under 40-46 ° environment, makes dry extract 2;
E. merge dry extract 1 and dry extract 2, be ground into powder, promptly.
Further make required powder, unguentum, electuary and capsule after being ground into powder among the described step e.
Theory of Chinese medical science is thought: under the normal condition, human body is keeping the health status of YIN and YANG in a relative equilibrium, as because of " seven emotions " factors such as " six desire ", make imbalance between YIN and YANG, cause symptoms such as " excess of YANG bringing about heat syndrome; excess of YIN bringing about cold syndrome ", the healthy energy internal memory, heresy can not be done, and the institute of heresy gathers, its gas must be empty, and " treatment is when to regulate equilibrium between yin and yang, and vigorate qi and replenish the blood be originally.Dialectical lupus erythematosus " the case cause of disease " " pathogenesis " should be the negative and positive disequilibrium, and excess of YIN leading to deficiency of YANG, vim and vigour can not normally be moved, and cold in blood then coagulates, and QI and blood is retarded by silt, three warmers are contained heat, and taste are long-pending wet, insufficiency of lung-QI, and heart kidney does not conform to, immunologic hypofunction, thereby blood clotting then stagnates formation noxious dampness invasion and attack body.
The prescription of medicine of the present invention is: Radix Sophorae Tonkinensis is monarch, and the Radix Astragali, Herba Artemisiae Annuae are minister, and the Radix Rehmanniae, Radix Scrophulariae, Cornu Bubali are assistant, Flos Lonicerae, and Radix Glycyrrhizae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Bulbus Lilii, Radix Asparagi, Ganoderma is for making.
Radix Sophorae Tonkinensis, Compendium of Material Medica is carried: " abnormal smells from the patient, sweet cold, nontoxic.Li Shizhen (1518-1593 A.D.): grind not usefulness, fried in shallow oil the soup clothes, and controlled the abdominal distention dyspnea with fullness of the chest in five minutes: (medicine) to be taken with wine three money, control woman's vim and vigour abdominal distention, can drive various worms again; Make the ball clothes, end dysentery, mill juice clothes end and suffer from the cold limbs due to intense heat in the interior cardiac and abdominal pain suddenly, and five kinds of hemorrhoid pains are ground juice and embrocated the swollen tinea alba of various heat, Serpentis, and Canis familiaris L., Aranea hinders." Kaibao Bencao " record: separate various medicine poison, pain relieving, the pyogenic infections from tumour or sore heresy that disappears is controlled fever and cough, and the acute jaundice of people and horse kills small worm, contains juice and separates the throat toxic swelling." preemergency side ": the treatment acute jaundice, Radix Sophorae Tonkinensis grinds, and water is obeyed three money, if folder legendary venomous insect gas send down with wine; Treatment cholera vomiting and diarrhea, Radix Sophorae Tonkinensis does not take three money with JUPITANG.Treat red white dysentery, Radix Sophorae Tonkinensis grinding honeyed pill such as Semen Firmianae are big, obey 20 balls at every turn, and boiled water takes on an empty stomach, obeys and can end for three times, white scales, gingival swelling and pain, throat distending pain on the enemy, the render meritorious service of clothes." Chinese medicine grand ceremony " carries: " Bencao Jingshu " Radix Sophorae Tonkinensis is discussed by each family, so sweet and malicious, so cold heat extraction, all malicious Bi Rebixin get poor gas, the flavor of sweetness and bitterness, and then all poison are explained by oneself, so be medicine on the detoxifcation heat clearing away.All pains must be because of in heat, and poison is analgesic to loose, and then pain is from ending, and skin ulcer is swollen, and acute jaundice is that the heat in blood utmost point is sent out from disappearing, so must generate heat, cough is then sent out in the steam rising, parasites is also damp and hot to be changed, thus know the master, and obtain special effect also more.
The Radix Astragali: nature and flavor are sweet, and tepor is nontoxic, and gas is thin rich, can rise and can fall, and belongs to cloudy middle-jiao yang, function of the spleen and stomach medicine, and the master returns the lunar edema caused by disorder of QI of brothers, few sun of starting with again, the few cloudy gate of vitality of foot.Its function cures mainly: the energy tonify deficiency, and the toxin expelling pain relieving, with the passing of time treatment carbuncle lose skin ulcer, leprosy, hemorrhoid, scrofula and children's's all kinds of diseases and ailments; But QI invigorating, it is deficient to mend the men and women, and the five internal organs blood stasis of dispelling quenches the thirst, and Li Yin gas is treated women's cold womb, and five kinds of over strain is become thin, and stomachache is let out dysentery, and the treatment of inside and outside poison holding, the carbuncle carbuncle on the back, tonifying the lung gas, nourishing the stomach gas is separated pyretic toxicity, and toxin expelling ends skin ulcer, and the benefiting blood and regulating blood circulation promoting pus discharge and tissue regeneration strengthening is persons particularly liable to develop skin infection's panacea.
Herba Artemisiae Annuae: the nature and flavor bitter cold, nontoxic.The Shennong's Herbal meaning: can control scabies, the scabies crust, pruritus is controlled pathogenic heat and is stayed between the joint, and materials for improving vision." all families of solar corona book on Chinese herbal medicine " said: the invigorating the spleen and replenishing QI of this product energy, and the tonify deficiency labor of making light of one's life by commiting suicide, beauty treatment, hair growth promoting, the double Bulbus Allii that goes is sent out, and kills pathogenic wind toxic, if pained heat Huang can be given birth to smashing juice clothes or external application.Li Shizhen (1518-1593 A.D.) is said: Herba Artemisiae Annuae gets spring wood, the gas of few sun the earliest, so the disease for the treatment of all is few sun, four minutes the disease of the moon of fainting.
Medicine garden: the Radix Astragali and Herba Artemisiae Annuae compatibility, go into liver, gallbladder, spleen, lung, the heart, large intestine the six channels, a removing toxic substances and promoting granulation, immunomodulating, the evanescence of heat of dispelling is wet, invigorating the spleen and replenishing QI, the two mutually beneficial shape.
The Radix Rehmanniae: nourishing YIN and benefiting blood, fever due to yin deficiency is quenched one's thirst, menoxenia, tonifying five ZANG-organs, physical strength profiting.
Radix Scrophulariae: nourishing YIN to lower pathogenic fire, the calentura excessive thirst is controlled in the relieving restlessness detoxifcation, and the fragrant labor of hectic fever due to YIN-deficiency is decided the five internal organs, clear toxic swelling.
Cornu Bubali: clearing away heat and cooling blood, the calentura headache is controlled in detoxifcation, heating coma, sore throat pharyngeal swelling.
Last three the flavor, go into liver, spleen, lung, stomach, kidney channel, beneficial vital essence, bone and muscle strengthening, separate vicious, heat clearing away and restlessness relieving, removing heat from blood and promoting blood circulation, YIN nourishing and the production of body fluid promoting.
Flos Lonicerae, Radix Glycyrrhizae, Radix Arnebiae (Radix Lithospermi), Flos Carthami is compatible is messenger drug, the side's of going into effect, and heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, nourshing Yin and drynsessmoistening prescription, the QI invigorating nourishing the stomach.Bulbus Lilii, Radix Asparagi, Ganoderma nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, nourshing Yin and drynsessmoistening prescription, the lung heat clearing pathogenic fire reducing improves immunity, and the side's of going into contingent lupus erythematosus of treatment merges syndrome, and can alleviate toxic and side effects and untoward reaction that the Western medicine medication occurs.
In order to obtain further therapeutic effect, medicine of the present invention adds Radix Panacis Quinquefolii on the basis of above prescription, and the West participates in cardiopulmonary kidney three warps, the lung heat clearing kidney, cool heart spleen can be subsidized edema caused by disorder of QI with pathogenic fire reducing, and can tonification blood system, promoting the production of body fluid to quench thirst, and the nourishing YIN for suppressing the hyperactive YANG controlling nocturnal emission with astringent drugs unique effect of calming the nerves is arranged.
Medicine of the present invention adopts modernized Chinese medicine preparation technology to be prepared into multiple medicinal preparation for oral administration, especially powder, unguentum, electuary or capsule.
Compared with prior art, beneficial effect of the present invention is embodied in:
1. medicine of the present invention has solid to be set upright, the kidney tonifying nourishing the liver, and QI invigorating is supported lung, nourishing YIN for suppressing the hyperactive YANG, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgesic, the function of enhance immunity has certain curative effect to treatment lupus erythematosus and anti-multiple toxin.
2. compare with similar medicine, ingredient of the present invention is cheap, easy to use having no side effect.
For proving above-mentioned advantage, it is apparent in view that medicine of the present invention has carried out the clinical verification curative effect of following examples 1. capsules, and curative effect is as follows:
1. the experimenter originates and sample content
The experimenter derives from the lupus erythematosus patient that makes a definite diagnosis totally 60 examples, male's 8 examples wherein, women's 52 examples, age 18-45 year, the course of disease 6 months～7 years.
2. the usage and dosage and the course of treatment:
Each 1.0 grams, 2 times on the one; With 60 days was 1 course of treatment.
3. efficacy assessment standard:
(1) produce effects: symptom and sign disappear, and lab testing antinuclear antibody titre descends, and anti-ds-DNA antibody is turned out cloudy or hanged down titre, take medicine continuously to keep the state of an illness to alleviate.
(2) take a turn for the better: symptom and sign major part disappear or alleviate, and lab index is improved, and taking medicine continuously to keep stable disease.
(3) do not heal: symptom and sign and lab testing do not have improvement.
4. therapeutic outcome: produce effects person 42, and the responder 18, and the nonresponder does not have, total effective rate 100%.
5. safety adverse events: in process of the test, do not observe other obvious adverse reaction.
6. conclusion: medicine of the present invention has solid to be set upright, the kidney tonifying nourishing the liver, and QI invigorating is supported lung, nourishing YIN for suppressing the hyperactive YANG, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgesic, the function of enhance immunity has certain curative effect to treatment lupus erythematosus and anti-multiple toxin.
The specific embodiment
Embodiment 1
Raw material (kg): Radix Sophorae Tonkinensis 8, the Radix Astragali 6.5, Herba Artemisiae Annuae 6, the Radix Rehmanniae 6, Radix Scrophulariae 6, Cornu Bubali 6, Flos Lonicerae 5, Radix Glycyrrhizae 2.5, Radix Arnebiae (Radix Lithospermi) 5, Flos Carthami 2.5, Bulbus Lilii 5, Radix Asparagi 4.7, Ganoderma 2.5, Radix Panacis Quinquefolii 4.5.
Preparation process is:
A. take by weighing each raw medicinal material by weight;
B. Flos Lonicerae, Radix Glycyrrhizae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Bulbus Lilii, Radix Asparagi, Ganoderma are carried out the water distillation, extract volatile oil;
C. the solid medicine material after the distillation adds the decocting secondary, each amount of water was not advisable to have medical material, merged to fry in shallow oil for twice to filter to get filtrate, and added the ethanol of 90-95% after concentrated, make ethanol content reach 60-80%, precipitate with ethanol, filter pure liquid, reclaim the ethanol reconcentration, concentrate the back and add Extraction oil, under 40-46 °, drying makes dry extract 1;
D. Radix Sophorae Tonkinensis, the Radix Astragali, Herba Artemisiae Annuae, the Radix Rehmanniae, Radix Panacis Quinquefolii, Radix Scrophulariae and Cornu Bubali are added together the ethanol of 90-95%, carry out reflux, extract,, extracting solution reclaims ethanol, and is dry under 40-46 ° environment, makes dry extract 2;
E. merge dry extract 1 and dry extract 2, be ground into powder, further the encapsulated capsule of making.
Embodiment 2
Raw material (kg): Radix Sophorae Tonkinensis 8, the Radix Astragali 6.5, Herba Artemisiae Annuae 6, the Radix Rehmanniae 6, Radix Scrophulariae 6, Cornu Bubali 6, Flos Lonicerae 5, Radix Glycyrrhizae 2.5, Radix Arnebiae (Radix Lithospermi) 5, Flos Carthami 2.5, Bulbus Lilii 5, Radix Asparagi 4.7, Ganoderma 2.5, Radix Panacis Quinquefolii 4.5.
Preparation process is:
A. take by weighing each raw medicinal material by weight;
B. Flos Lonicerae, Radix Glycyrrhizae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Bulbus Lilii, Radix Asparagi, Ganoderma are carried out the water distillation, extract volatile oil;
C. the solid medicine material after the distillation adds the decocting secondary, each amount of water was not advisable to have medical material, merged to fry in shallow oil for twice to filter to get filtrate, and added the ethanol of 90-95% after concentrated, make ethanol content reach 60-80%, precipitate with ethanol, filter pure liquid, reclaim the ethanol reconcentration, concentrate the back and add Extraction oil, under 40-46 °, drying makes dry extract 1;
D. Radix Sophorae Tonkinensis, the Radix Astragali, Herba Artemisiae Annuae, the Radix Rehmanniae, Radix Panacis Quinquefolii, Radix Scrophulariae and Cornu Bubali are added together the ethanol of 90-95%, carry out reflux, extract,, extracting solution reclaims ethanol, and is dry under 40-46 ° environment, makes dry extract 2;
E. merge dry extract 1 and dry extract 2, be ground into powder, promptly get powder.
Embodiment 3
Raw material (kg): Radix Sophorae Tonkinensis 5, the Radix Astragali 4, Herba Artemisiae Annuae 3, the Radix Rehmanniae 3, Radix Scrophulariae 3, Cornu Bubali 3, Flos Lonicerae 2, Radix Glycyrrhizae 1, Radix Arnebiae (Radix Lithospermi) 2, Flos Carthami 1, Bulbus Lilii 2, Radix Asparagi 2, Ganoderma 1, Radix Panacis Quinquefolii 2.
Preparation process is:
A. take by weighing each raw medicinal material by weight;
B. Flos Lonicerae, Radix Glycyrrhizae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Bulbus Lilii, Radix Asparagi, Ganoderma are carried out the water distillation, extract volatile oil;
C. the solid medicine material after the distillation adds the decocting secondary, each amount of water was not advisable to have medical material, merged to fry in shallow oil for twice to filter to get filtrate, and added the ethanol of 90-95% after concentrated, make ethanol content reach 60-80%, precipitate with ethanol, filter pure liquid, reclaim the ethanol reconcentration, concentrate the back and add Extraction oil, under 40-46 °, drying makes dry extract 1;
D. Radix Sophorae Tonkinensis, the Radix Astragali, Herba Artemisiae Annuae, the Radix Rehmanniae, Radix Panacis Quinquefolii, Radix Scrophulariae and Cornu Bubali are added together the ethanol of 90-95%, carry out reflux, extract,, extracting solution reclaims ethanol, and is dry under 40-46 ° environment, makes dry extract 2;
E. merge dry extract 1 and dry extract 2, be ground into powder, further make electuary.
Embodiment 4
Raw material (kg): Radix Sophorae Tonkinensis 11, the Radix Astragali 9, Herba Artemisiae Annuae 9, the Radix Rehmanniae 9, Radix Scrophulariae 9, Cornu Bubali 9, Flos Lonicerae 8, Radix Glycyrrhizae 4, Radix Arnebiae (Radix Lithospermi) 8, Flos Carthami 4, Bulbus Lilii 8, Radix Asparagi 7, Ganoderma 4, Radix Panacis Quinquefolii 7.
Preparation process is:
A. take by weighing each raw medicinal material by weight;
B. Flos Lonicerae, Radix Glycyrrhizae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Bulbus Lilii, Radix Asparagi, Ganoderma are carried out the water distillation, extract volatile oil;
C. the solid medicine material after the distillation adds the decocting secondary, each amount of water was not advisable to have medical material, merged to fry in shallow oil for twice to filter to get filtrate, and added the ethanol of 90-95% after concentrated, make ethanol content reach 60-80%, precipitate with ethanol, filter pure liquid, reclaim the ethanol reconcentration, concentrate the back and add Extraction oil, under 40-46 °, drying makes dry extract 1;
D. Radix Sophorae Tonkinensis, the Radix Astragali, Herba Artemisiae Annuae, the Radix Rehmanniae, Radix Panacis Quinquefolii, Radix Scrophulariae and Cornu Bubali are added together the ethanol of 90-95%, carry out reflux, extract,, extracting solution reclaims ethanol, and is dry under 40-46 ° environment, makes dry extract 2;
E. merge dry extract 1 and dry extract 2, be ground into powder, further make unguentum.
Embodiment 5
Raw material (kg): Radix Sophorae Tonkinensis 7, the Radix Astragali 6, Herba Artemisiae Annuae 5, the Radix Rehmanniae 5, Radix Scrophulariae 5, Cornu Bubali 5, Flos Lonicerae 4, Radix Glycyrrhizae 2, Radix Arnebiae (Radix Lithospermi) 4, Flos Carthami 2, Bulbus Lilii 4, Radix Asparagi 4, Ganoderma 2, Radix Panacis Quinquefolii 4.
Preparation process is identical with embodiment 1.
Embodiment 6
Raw material (kg): Radix Sophorae Tonkinensis 9, the Radix Astragali 7, Herba Artemisiae Annuae 7, the Radix Rehmanniae 7, Radix Scrophulariae 7, Cornu Bubali 7, Flos Lonicerae 6, Radix Glycyrrhizae 3, Radix Arnebiae (Radix Lithospermi) 6, Flos Carthami 3, Bulbus Lilii 6, Radix Asparagi 5, Ganoderma 3, Radix Panacis Quinquefolii 5.
Preparation process is identical with embodiment 1.
Claims (6)
1. a medicine for the treatment of lupus erythematosus is characterized in that it is the medicament of being made by following materials of weight proportions: Radix Sophorae Tonkinensis 5-11, Radix Astragali 4-9, Herba Artemisiae Annuae 3-9, Radix Rehmanniae 3-9, Radix Scrophulariae 3-9, Cornu Bubali 3-9, Flos Lonicerae 2-8, Radix Glycyrrhizae 1-4, Radix Arnebiae (Radix Lithospermi) 2-8, Flos Carthami 1-4, Bulbus Lilii 2-8, Radix Asparagi 2-7, Ganoderma 1-4, Radix Panacis Quinquefolii 2-7.
2. the medicine of treatment lupus erythematosus according to claim 1, wherein the weight proportion of each raw material is: Radix Sophorae Tonkinensis 7-9, Radix Astragali 6-7, Herba Artemisiae Annuae 5-7, Radix Rehmanniae 5-7, Radix Scrophulariae 5-7, Cornu Bubali 5-7, Flos Lonicerae 4-6, Radix Glycyrrhizae 2-3, Radix Arnebiae (Radix Lithospermi) 4-6, Flos Carthami 2-3, Bulbus Lilii 4-6, Radix Asparagi 4-5, Ganoderma 2-3, Radix Panacis Quinquefolii 4-5.
3. the medicine of treatment lupus erythematosus according to claim 1, wherein the weight proportion of each raw material is: Radix Sophorae Tonkinensis 8, the Radix Astragali 6.5, Herba Artemisiae Annuae 6, the Radix Rehmanniae 6, Radix Scrophulariae 6, Cornu Bubali 6, Flos Lonicerae 5, Radix Glycyrrhizae 2.5, Radix Arnebiae (Radix Lithospermi) 5, Flos Carthami 2.5, Bulbus Lilii 5, Radix Asparagi 4.7, Ganoderma 2.5, Radix Panacis Quinquefolii 4.5.
4. according to the medicine of claim 1,2 or 3 described treatment lupus erythematosus, described medicament is powder, unguentum, electuary or capsule.
5. the preparation method of a claim 1,2 or 3 described treatment lupus erythematosus medicines may further comprise the steps:
A. take by weighing each raw medicinal material by weight;
B. Flos Lonicerae, Radix Glycyrrhizae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Asparagi, Bulbus Lilii and Ganoderma are carried out the water distillation, its volatile oil is provided;
C. the solid medicine material after the distillation adds decocting twice, each amount of water was not advisable to have spice, merge decocting liquid twice, filter to get filtrate, add the ethanol of 90%-95% after concentrating, make pure content reach 60%-80%, precipitate with ethanol filter pure liquid, reclaim the ethanol reconcentration, concentrate the back and add Extraction oil, dry under 40-46 °, make dry extract 1;
D. Radix Sophorae Tonkinensis, the Radix Astragali, Herba Artemisiae Annuae, the Radix Rehmanniae, Radix Panacis Quinquefolii, Radix Scrophulariae and Cornu Bubali are added together the ethanol of 90%-95%, carry out reflux, extract,, extracting solution reclaims ethanol, and is dry under 40-46 ° environment, makes dry extract 2;
E. merge dry extract 1 and dry extract 2, be ground into powder, promptly.
6. according to the preparation method of the described treatment lupus erythematosus of claim 5 medicine, medicament is further made required powder, unguentum, electuary or capsule after being ground into powder among the described step e.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106871A (en) * | 2015-10-08 | 2015-12-02 | 万健 | Traditional Chinese medicine preparation for treating systemic lupus erythematosus |
| CN107582601A (en) * | 2017-10-30 | 2018-01-16 | 罗天碧 | A kind of medicine for treating lupus erythematosus and preparation method thereof |
| EP3441078A4 (en) * | 2016-04-07 | 2019-11-27 | Beijing Lu De Kai Qi Co., Ltd. | Pharmaceutical product for treating lupus erythematosus and combined immune defect, and preparation and application thereof |
| CN110755557A (en) * | 2019-11-21 | 2020-02-07 | 云南省中医医院 | Preparation method of traditional Chinese medicine pills for treating toxic heat flourishing type lupus erythematosus |
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| CN101040991A (en) * | 2007-04-19 | 2007-09-26 | 牟培新 | Chinese traditional medicine compound took orally for treating lupus erythematosus |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106871A (en) * | 2015-10-08 | 2015-12-02 | 万健 | Traditional Chinese medicine preparation for treating systemic lupus erythematosus |
| EP3441078A4 (en) * | 2016-04-07 | 2019-11-27 | Beijing Lu De Kai Qi Co., Ltd. | Pharmaceutical product for treating lupus erythematosus and combined immune defect, and preparation and application thereof |
| CN107582601A (en) * | 2017-10-30 | 2018-01-16 | 罗天碧 | A kind of medicine for treating lupus erythematosus and preparation method thereof |
| CN110755557A (en) * | 2019-11-21 | 2020-02-07 | 云南省中医医院 | Preparation method of traditional Chinese medicine pills for treating toxic heat flourishing type lupus erythematosus |
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