CN104857370A - Traditional Chinese medicine composition for treating breast cancer - Google Patents

Traditional Chinese medicine composition for treating breast cancer Download PDF

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CN104857370A
CN104857370A CN201510311019.2A CN201510311019A CN104857370A CN 104857370 A CN104857370 A CN 104857370A CN 201510311019 A CN201510311019 A CN 201510311019A CN 104857370 A CN104857370 A CN 104857370A
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杜小卫
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杜小卫
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Abstract

The invention provides a traditional Chinese medicine composition for treating a breast cancer. The traditional Chinese medicine composition conforms to the principle of traditional Chinese medicine combination. Fundamentally, salviae miltiorrhizae, cortex moutan, chrysanthemum, flos carthami, sinapis alba, vervain, paeonia suffruticosa, Chinese actinidia root, water chestnut, cicca arietina, leech, toad skin, selfheal, ganoderma lucidum and berberis poiretii schneid are taken as monarch and minister medicines for clearing away heat and toxic materials, activating blood circulation to arrest pain, and softening hardness to dissipate stagnation; and ligusticum wallichii, peach kernel, cassia twig, rhizoma corydalis, coix leaf, Chinese yam, polygonum multiflorum, bitter gourd, mulberry, dogwood, tortoise shell, rhizoma atractylodis macrocephalae, radix rehmanniae praeparata, angelica sinensis, aspongopus, tangerine, lemon, jujube and wolfberry fruit are taken as assistant and guide medicines for playing a coordinating role, discharging the liver, relieving depression, promoting qi flow to regulate the stomach, replenishing vigor, and improving the immunity, so that the traditional Chinese medicine composition is capable of enhancing the functions of monarch medicines and minister medicines, and restricting the toxic or side effects of other medicines.

Description

A kind of Chinese medicine composition for the treatment of breast cancers
Technical field
The present invention relates to Chinese medicine and pharmacy technical field, specifically a kind of Chinese medicine composition for the treatment of breast cancers.
Background technology
The traditional Chinese medical science is classified as breast carcinoma breast carcinoma.Ancient medicine is thought, breast carcinoma is often depression of liver-QI in early days, then occurs thereafter the symptom of qi depression to blood stasis, QI and blood stasis, for a long time then heat-dissipating, causes insidious vigorous, with the passing of time causes asthenia of qi and blood and decline.Current breast cancer treatment is based on doctor trained in Western medicine, and the traditional Chinese medical science is mainly through individualized treatment, and auxiliary doctor trained in Western medicine is better improved in quality of life and in relief of symptoms to patient.It is tangible long-pending that breast is removed in operation, and residual poison still exists.Chemotherapeutic belongs to pyretic toxicity, and radiotherapy belongs to pathogenic fire, pathogenic heat, and the internal organs damage of these pathogens to human body is very clear and definite, and the traditional Chinese medical science is the body resistance strengthening and constitution consolidating treatment.
Patient is postoperative there will be weak, the weak performance such as to breathe hard; Also have local swelling, twinge etc., the effect improving symptom, reduce blood viscosity, prevent and treat recurrence can be played by Chinese traditional treatment.Chinese medicine also can combine with radiotherapy, and after some patients finish radiotherapy, the situations such as Jiao is dark, be full of cracks, dry mouth and tougue appear in local skin, coordinate the medicine of nourishing YIN and clearing away heat, can play certain curative effect.Alleviate toxic and side effects, extend life cycle.
Summary of the invention
Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, and the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost.The present invention is the effect that Chinese medicine preparation has warming YANG and strengthening body resistance, dispersing the stagnated live-QI to relieve the stagnation of QI, benefiting qi and nourishing blood, promoting blood circulation, removing blood stasis and relieving pain, reaches the object of anticancer diffusion simultaneously.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, and focus of going directly, healing time is short, not easily recurs after healing.
The invention provides a kind of Chinese medicine composition for the treatment of breast cancers, medicine of the present invention meets the principle of drug matching, first fundamentally start with, with Radix Salviae Miltiorrhizae, Cortex Moutan, Flos Chrysanthemi, Flos Carthami, Semen Sinapis Albae, Herba Verbenae, Cortex Moutan, Radix Actinidiae Chinensis, Pedicellus et Pericarpium Trapae, Semen Ciceris Arietini, Hirudo, Cutis Bufonis, Spica Prunellae, Ganoderma and Radix Berberidis are that the medicine of the monarch and his subjects is drawn out pus by applying a plaster to the affected part for heat clearing away, promoting blood circulation and stopping pain, hard masses softening and resolving, with Rhizoma Chuanxiong, Semen Persicae, Ramulus Cinnamomi, Rhizoma Corydalis, Folium Coicis, Rhizoma Dioscoreae, Radix Polygoni Multiflori, Fructus Momordicae charantiae, Fructus Mori, Fructus Corni, Carapax Et Plastrum Testudinis, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Aspongopus, Fructus Citri tangerinae, Fructus Citri Limoniae, Fructus Jujubae and Fructus Lycii play coordinative role for the medicine of assisting a ruler in governing a country, dispersing the stagnated live-QI to relieve the stagnation of QI, relieving QI stagnancy in the stomach, supplement vigour, improve immunity, strengthen monarch drug and ministerial drug function, and restrict the toxic and side effects of other drug.Above material combination makes each efficacy of drugs produce synergism, giving consideration to both the incidental and fundamental, medication is gentle, there is warming YANG and strengthening body resistance, dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, hard masses softening and resolving supplements effect of vigour, flowers and fruits are used as medicine, make its mouthfeel good, also do not lose the property of medicine and drug effect, by coordinating traditional western medical treatment, thus can effectively spread by anticancer, better improve patients symptomatic, alleviate or suppress General Symptoms to react, protect each tract function, improve the effective percentage for the treatment of breast cancers, alleviate toxic and side effects, extend life cycle, reduce mortality.
the property of medicine and the pharmacology of medicine selected by the present invention are respectively:
Radix Salviae Miltiorrhizae:
[meridian distribution of property and flavor] is bitter, is slightly cold.GUIXIN, Liver Channel.
[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris." book on Chinese herbal medicine justice ": Radix Salviae Miltiorrhizae, being slightly cold of " herbal classic " meaning, TAO Hong-Jing has doubted it by mistake, and Miao's secondary alcohol also doubts it, and stupid to a stone is transform tepor into." herbal classic ": main trusted subordinate's pathogen, borborygmus are faint as leaked water, and cold and heat gather; Broken disease, except abdominal mass, stops stuffy sensation with restlessness, QI invigorating." WU Pu Bencao ": control cardiac and abdominal pain." not Lu ": nourish blood, remove trusted subordinate's obstinate disease stagnation of QI, stiffness along the spinal column, foot numbness; Except wind, Xing stays heat, takes sharp people for a long time.TAO Hong-Jing: stain beverage it, treat migratory arthralgia." property of medicine opinion ": control flaccidity of the lower limbs, pain numbness, main attacked by pestiferous factors; Control stomachache, gas is done sound ring and is shouted." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed." the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful palpitation with a distress feeling, palpitation with fear is insomnia." detailed outline ": invigorate blood circulation, logical percardium.Control colic." choosing of Yunnan Chinese herbal medicine ": promoting blood circulation to remove blood stasis, sedation-analgesia.Control menoxenia, dysmenorrhea, rheumatic arthralgia, metrorrhagia, spit blood, mastitis, carbuncle.
Cortex Moutan
[nature and flavor] are cold in nature, bitter in the mouth, pungent.
[function cures mainly] clearing away heat and cooling blood, blood circulation promoting competent silt.For maculae caused by violent heat pathogen, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.
Flos Chrysanthemi:
There is effect of dispelling wind, heat clearing away, improving eyesight, removing toxic substances.The disease such as primary treatment headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Modern pharmacological research shows, Flos Chrysanthemi has treatment coronary heart disease, reduces blood pressure, prevents hyperlipidemia, antibacterial, antiviral, antiinflammatory, anti-ageing multiple pharmacologically active of waiting for a long time.
Flos Carthami:
[nature and flavor] are warm in nature, acrid in the mouth.
[function cures mainly] invigorates blood circulation latus rectum, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury, be suitable for various varicosis, peripheral neuritis, blood circulation, lower limb numbness or the congestion such as livid purple.
Semen Sinapis Albae:
[nature and flavor] odorless, acrid in the mouth, peppery.
" detailed outline ": " pungent, heat, nontoxic."
" Traditional Chinese Medicine in Sichuan will ": " warm in nature, acrid in the mouth is nontoxic."
[return through] " must book on Chinese herbal medicine be joined ": " enter meridian of Hand-TAI YIN."
[function]: warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.
[curing mainly]: reduce phlegm by drink; Mass dissipating and swelling eliminating.Main cough with asthma abundant expectoration; Fullness in the chest and hypochondriac pain; Numb limbs and tense tendons; Arthralgia; Multiple abscess caused by damp-phlegm; Carbuncle of yin nature toxic swelling.Control acute mastitis, breast carcinoma, mammary gland pain, tuberculosis, phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.
Herba Verbenae:
Meridian distribution of property and flavor: bitter, cool.Return liver, spleen channel.
Function cures mainly: heat and toxic materials clearing away medicine; Promoting blood circulation to restore menstrual flow medicine; Edema-alleviating diuretic; Preventing the attack (or recurrence) of malaria medicine; Promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema.For lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria.
Cortex Moutan: Paeonia suffruticosa not only has ornamental value, but also there is very high medical value.Being processed into " Cortex Moutan " by the root of Paeonia suffruticosa, is famous and precious Chinese herbal medicine.Its cold nature, acrid in the mouth, nontoxic, enter the heart, liver, kidney three warp, have dissipating blood stasis blood, purify the blood and blood, pain relieving, the effect of stimulating the menstrual flow, reduce blood pressure in addition, effect of anti-inflammation, clothes can be lengthened the life by beneficial body for a long time.Nourish blood regulating liver-QI, loose strongly fragrant blood stasis dispelling, is applicable to chloasma faciei, skin aging, and normal drink QI and blood is lived lung, and appearance is ruddy, improves menoxenia, dysmenorrhea, only sweating due to debility, night sweat.
Radix Actinidiae Chinensis:
[nature and flavor] " Shaanxi Chinese herbal medicine ": " acid is micro-sweet, cool, slightly poisonous."
[function cures mainly] heat clearing away, diuresis, invigorates blood circulation, detumescence.Treating the liver is scorching, edema, traumatic injury, rheumatic arthritis, stranguria with turbid discharge, leukorrhagia, furuncle, scrofula.1. " Guizhou side's medicine among the people collection ": " diuresis, cathartic.Control ascites; External synthetism, disappear wound." 2. " Zhejiang conventional medical herbs among the people ": " stomach invigorating, invigorates blood circulation, lactogenic, antiinflammatory." 3. " Shaanxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, promoting blood circulation and detumescence, anticancer.Control furuncle, scrofula."
Pedicellus et Pericarpium Trapae:
Property, sweet, puckery, flat, nontoxic.Sarcocarp rich in starch, in addition containing enriching glucose, protein, vitamin (B, C) etc.Have that clearing away summer-heat is antipyretic, QI invigorating stomach invigorating, only quench one's thirst, alcoholic intoxication, diuresis lactogenesis, the effect such as anticancer.Fresh Pedicellus et Pericarpium Trapae is eaten raw, heat of relieving summer heat, only excessive thirst, and vexed, the thirsty spontaneous perspiration of all summer-heat impairment of body fluid, fever of the body, inappetence person, can make dietetic therapy fruit; Pedicellus et Pericarpium Trapae prepared food is warm in nature, and gas in energy strengthening the spleen and stomach, benefit, the tired Mental fatigue of all deficiency of the spleen causing weakness of QI, body, anorexia, the meciless person of extremity should eat.Be applicable to the control of gastric ulcer, dysentery, the esophageal carcinoma, breast carcinoma, uterus carcinoma and other cancers.
Semen Ciceris Arietini:
Regulating middle-JIAO and making the adverse QI downward, diuresis, separates sore.Control cramp caused by acute vomiting and diarrhea, beriberi, carbuncle.
1. " Shaoxing edits Zhenglei Bencao ": a homophony battalion defends, flat gas in benefit.
2. " daily book on Chinese herbal medicine ": lower milk of cooking.
3. " detailed outline ": grind into powder and be coated with carbuncle, variola.
4. " Bencao Congxin ": reason taste.
5. " medical center bun is wanted ": diuresis.
6. " with breath occupy diet spectrum ": cook, and in promote the production of body fluid, the therapeutic method to keep the adverse QI flowing downwards of quenching the thirst, lactogenesis relieving distension.
Trophic analysis: be rich in vitamin C and can the enzyme of nitrosamine in decomposer in the tender leaf of Huis soybean pod and bean seedlings, can decomposing nitrosamine, has the effect of anti-cancer and cancer-preventing.Semen Ciceris Arietini and general vegetable different, the materials such as the acid of contained only wooden fork, gibberellins and the solidifying element of plant, have anti-inflammation, strengthen metabolic function.Containing the dietary fiber compared with horn of plenty in garden pea and bean seedlings, can constipation be prevented, have bowel relieving effect.1. enhancing human body immunity function: the various nutrient substance being rich in needed by human body in Semen Ciceris Arietini, especially containing high quality protein, can improve resistance against diseases and the rehabilitation ability of body.2. cancer preventing and treating: be rich in carotene in Semen Ciceris Arietini, can prevent the synthesis of human carcinogen's material after edible, thus reduces the formation of cancerous cell, reduces the sickness rate of human carcinoma.3. tonneau large intestine: be rich in crude fibre in Semen Ciceris Arietini, can promote intestinal peristalsis, keeps stool freely, can play the effect of clean large intestine.
Hirudo:
[meridian distribution of property and flavor] salty in the mouth, hardship, property is put down, nontoxic.Return Liver Channel.
[function cures mainly] removing blood stasis, eliminating mass of stimulating the menstrual flow abdominal mass.This product removing blood stasis power is large, is applicable to blood stasis and stagnates the diseases such as amenorrhea, tumor mass and the treating swelling and pain by traumatic injury caused.The benefaction of gas raw meat, enters blood broken loose.
Cutis Bufonis:
[meridian distribution of property and flavor] acrid in the mouth; Cool in nature; Poisonous; GUIXIN; Liver; Spleen; Lung meridian.
[function cures mainly] detoxicating and resolving stagnation of pathogens; Removing food stagnancy diuretic; Destroying parasites for curing malnutrition.Main dysentery cellulitis; Furuncle; Carbuncle on the back; Scrofula; Malignant boil; The lump in the abdomen hypochondriac lump; Expand; Edema; Infantile malnutrition; Tetanus; Chronic cough and asthma.Function removing toxic substances, diuretic, relieving distension, cure mainly various tumor.
Spica Prunellae: acrid in the mouth, bitterness are cold, return Liver Channel, can liver heat removing and eyesight improving, dispersing swelling and dissipating binds, suppressing the hyperactive liver sun.
Ganoderma:
[nature and flavor] are for sweet, flat, GUIXIN, lung, liver, kidney channel.
[curing mainly] asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.
Fructus Lycii:
[nature and flavor] are sweet, flat, enter liver, stomach two warp, double enter lung meridian;
[function cures mainly] the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.Cure mainly: control apoplexy dizzy, asthenia, allly see blood disorder, cough blood, flaccidity, faint, contraction, disappear miasma, hinders dry, seminal emission, reddish and whitish turbid urine, beriberi, the arthroncus of knee.
Radix Berberidis:
[nature and flavor] are bitter, cold.
[effect] heat clearing and damp drying, eliminating fire and detoxication.
Application
Mainly be applicable to colorectal cancer, tumor etc.
(1) for the colorectal cancer of hyperactivity of toxic heat, disease sees that times of defecation increases, with pus and blood mucus time just, and abdominal part distending pain, burning sensation of the anus etc., the fit applications such as normal and Herba Patriniae, Herba Hedyotidis Diffusae, Cortex Phellodendri.
(2) stop up the pulmonary carcinoma of containing for expectorant heat, disease sees heating, chest pain, out of breath, thirsty, constipation, cough with copious phlegm etc., often coordinates should have with Herba Taraxaci, Cortex Lycii, Folium Pyrrosiae, Herba Gnaphalii Affinis etc.
(3) for tumor patient through radiotherapy, Leukocytes after Chemotherapy reduce normal with the Radix Astragali, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Scrophulariae etc. blood medicine compatibility at the beginning of supplementing QI and nourishing YIN apply.
Rhizoma Chuanxiong:
[meridian distribution of property and flavor] is pungent, and temperature, returns liver, gallbladder, pericardium channel;
[effect] activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Blood-activating and qi-promoting, wind-expelling pain-stopping. for menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Semen Persicae:
[meridian distribution of property and flavor] property gan Ping, bitter in the mouth, enter lung, liver, large intestine channel;
[function cures mainly] has blood stasis removing and clots absorbing, moisturizes effect of laxation; Control amenorrhea, dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, traumatic injury, dryness of the intestine constipation.
Rhizoma Corydalis:
[nature,taste and action] acrid in the mouth, hardship, warm in nature.There is promoting blood circulation to remove blood stasis, the function of promoting the circulation of QI pain relieving.
[curing mainly usage] for whole body each portion qi depression to blood stasis pain, dysmenorrhea, amenorrhea, lump in the abdomen, postpartum stagnation, injury from falling down, herniahave a pain.Be decocted in water for oral dose.
Folium Coicis:
[collection] summer, autumn take.
[chemical composition] leaf is containing alkaloid.
[function cures mainly-Folium Coicis effect] has effect of warming spleen and stomach for dispelling cold, benefiting vital QI and blood, cures mainly cold syndrome of the stomach pain, the symptom of deficient qi and blood.
1. " Bencao Tujing ": for drinking perfume (or spice), beneficial hollow diaphragm.
2. " trifling record ": the summer-heat moon decocts drink, warming the stomach, replenishing QI and blood.
Rhizoma Dioscoreae:
[nature and flavor] sweet in the mouth, property are flat, enter lung, spleen, kidney channel;
[function cures mainly] has strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red disease such as swollen, fat of frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.
Radix Polygoni Multiflori:
[meridian distribution of property and flavor] is bitter, sweet, puckery, and temperature, returns liver, the heart, kidney channel.
[function cures mainly] detoxifies, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia, right neurasthenia, poliosis, alopecia, anemiatherapeutical effect is had etc. disease, therefore, delaying sanility, building body, health care heart.
Fructus Momordicae charantiae:
[meridian distribution of property and flavor] is bitter, cold.Return spleen, stomach, the heart, Liver Channel.
[effect] heat clearing away is dispelled heart-fire, removing toxic substances, improving eyesight, and QI invigorating benefit essence, quenches the thirst and relieve summer heat, control carbuncle.
Fructus Mori:
[nature and flavor] are sweet, are slightly cold; GUIXIN, liver, kidney channel.
[function cures mainly] controls hepatic and renal YIN deficiency, sends and takes off, constipation, and order is dark, tinnitus, former infections, articular instability.It is improved skin (comprising scalp) blood supply, nutrition skin, makes the effects such as the delicate and black hair of skin, and can slow down aging.Fructus Mori is that middle-aged and elderly people is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent.Fructus Mori has immunologic enhancement.Fructus Mori has effect of gain to spleen, has potentiation to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism; Fructus Mori can promote the growth of erythrocyte, prevents leukopenia, and has auxiliary curative effect to diseases such as treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenias.Fructus Mori has the effects such as promoting the production of body fluid to quench thirst, facilitating digestion, help defecation, and proper amount of edible can promote gastric secretion, stimulates enterokinesia and removes scorching.The traditional Chinese medical science is thought, Fructus Mori is sweet in flavor and cold in property, there is the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, the effect such as black hair improving eyesight.
Fructus Corni: property is flat, sweet in the mouth, acid, function nourishing the liver and kidney, astringing YIN to stop sweating emergency treatment of collapse, is nourishing kidney yin key medicine, is mainly used in syndrome of yin deficiency of liver and kidney, is applicable to the soreness of the waist and knees caused by Liver and kidney two void, vertigo and tinnitus, sexual impotence, seminal emission, frequent micturition, the diseases such as incessant sweating due to debility.
Carapax Et Plastrum Testudinis:
[meridian distribution of property and flavor] is salty, sweet, is slightly cold.Return liver, kidney, heart channel.
[function cures mainly] nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful.
The Rhizoma Atractylodis Macrocephalae:
[nature and flavor] are warm in nature, sweet in the mouth, hardship.
[effect] air making-up and spleen enlivening, can be used for asthenia weak breath, insufficiency of the spleen transporting mistake department.
Radix Rehmanniae Preparata:
[meridian distribution of property and flavor] property is sweet, tepor, enters liver, kidney channel.
[effect] nourishing the blood and yin, vital essence replenishing and marrow benifiting.
Radix Angelicae Sinensis:
[nature and flavor] are warm in nature, hide sweet, pungent.
[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Aspongopus:
[meridian distribution of property and flavor] property is salty, pungent, warm; Return stomach, liver, large intestine channel.
[effect] regulating QI to relieve pain, warming middle-JIAO is supporing yang, relieves internal heat anticancer, for cold syndrome of the stomach distending pain, and stomachache due to hyperactive liver-QI attacking the stomach, impotence due to deficiency of the kidney, soreness of waist and knee joint.
Fructus Citri tangerinae:
[meridian distribution of property and flavor] sweet in the mouth is sour, cool in nature, enters lung, stomach warp;
[function] has appetizing and regulates the flow of vital energy, effect of relieving cough and moistening lung, cures mainly very thirsty in septum pectorale stagnation of QI, mouth, cough due to lung-heat etc.
Fructus Citri Limoniae:
[meridian distribution of property and flavor] sour in the mouth is sweet, property is flat, enters liver, stomach warp.
[function] has preventing phlegm from forming and stopping coughing, promotes the production of body fluid, effect of spleen invigorating; Mainly treating bronchitis, pertussis, vitamin C deficiency, heatstroke excessive thirst, inappetence, pregnant woman's disorder of stomach-QI, poor appetite, eructation etc.
Fructus Jujubae:
[meridian distribution of property and flavor] is sweet, and temperature, returns spleen, stomach warp;
[function cures mainly] invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of breast cancers, in described Chinese medicine composition, the ratio of weight and number of various crude drug is:
Radix Salviae Miltiorrhizae 20-30 part, Cortex Moutan 20-30 part, Flos Chrysanthemi 20-30 part, Flos Carthami 20-30 part, Semen Sinapis Albae 20-30 part, Herba Verbenae 20-30 part, Cortex Moutan 20-30 part, Radix Actinidiae Chinensis 20-30 part, Pedicellus et Pericarpium Trapae 20-30 part, Semen Ciceris Arietini 20-30 part, Hirudo 20-30 part, Cutis Bufonis 20-30 part, Spica Prunellae 20-30 part, Ganoderma 20-30 part, Radix Berberidis 20-30 part, Rhizoma Chuanxiong 15-25 part, Semen Persicae 15-25 part, Ramulus Cinnamomi 15-25 part, Rhizoma Corydalis 15-25 part, Folium Coicis 15-25 part, Rhizoma Dioscoreae 15-25 part, Radix Polygoni Multiflori 15-25 part, Fructus Momordicae charantiae 15-25 part, Fructus Mori 15-25 part, Fructus Corni 15-25 part, Carapax Et Plastrum Testudinis 15-25 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Radix Rehmanniae Preparata 15-25 part, Radix Angelicae Sinensis 15-25 part, Aspongopus 15-25 part, Fructus Citri tangerinae 15-25 part, Fructus Citri Limoniae 15-25 part, Fructus Jujubae 15-25 part, Fructus Lycii 15-25 part.
Described a kind of Chinese medicine composition for the treatment of breast cancers, the ratio of weight and number of various crude drug also can be:
Radix Salviae Miltiorrhizae 22-28 part, Cortex Moutan 22-28 part, Flos Chrysanthemi 22-28 part, Flos Carthami 22-28 part, Semen Sinapis Albae 22-28 part, Herba Verbenae 22-28 part, Cortex Moutan 22-28 part, Radix Actinidiae Chinensis 22-28 part, Pedicellus et Pericarpium Trapae 22-28 part, Semen Ciceris Arietini 22-28 part, Hirudo 22-28 part, Cutis Bufonis 22-28 part, Spica Prunellae 22-28 part, Ganoderma 22-28 part, Radix Berberidis 22-28 part, Rhizoma Chuanxiong 16-22 part, Semen Persicae 16-22 part, Ramulus Cinnamomi 16-22 part, Rhizoma Corydalis 16-22 part, Folium Coicis 16-22 part, Rhizoma Dioscoreae 16-22 part, Radix Polygoni Multiflori 16-22 part, Fructus Momordicae charantiae 16-22 part, Fructus Mori 16-22 part, Fructus Corni 16-22 part, Carapax Et Plastrum Testudinis 16-22 part, Rhizoma Atractylodis Macrocephalae 16-22 part, Radix Rehmanniae Preparata 16-22 part, Radix Angelicae Sinensis 16-22 part, Aspongopus 16-22 part, Fructus Citri tangerinae 16-22 part, Fructus Citri Limoniae 16-22 part, Fructus Jujubae 16-22 part, Fructus Lycii 16-22 part.
Described a kind of Chinese medicine composition for the treatment of breast cancers, the ratio of weight and number of various crude drug can also be:
Radix Salviae Miltiorrhizae 25 parts, Cortex Moutan 25 parts, Flos Chrysanthemi 25 parts, 25 parts, Flos Carthami, Semen Sinapis Albae 25 parts, Herba Verbenae 25 parts, Cortex Moutan 25 parts, Radix Actinidiae Chinensis 25 parts, Pedicellus et Pericarpium Trapae 25 parts, Semen Ciceris Arietini 25 parts, Hirudo 25 parts, Cutis Bufonis 25 parts, Spica Prunellae 25 parts, Ganoderma 25 parts, Radix Berberidis 25 parts, Rhizoma Chuanxiong 20 parts, 20 parts, Semen Persicae, Ramulus Cinnamomi 20 parts, Rhizoma Corydalis 20 parts, Folium Coicis 20 parts, Rhizoma Dioscoreae 20 parts, Radix Polygoni Multiflori 20 parts, 20 parts, Fructus Momordicae charantiae, 20 parts, Fructus Mori, Fructus Corni 20 parts, Carapax Et Plastrum Testudinis 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Rehmanniae Preparata 20 parts, Radix Angelicae Sinensis 20 parts, Aspongopus 20 parts, Fructus Citri tangerinae 20 parts, 20 parts, Fructus Citri Limoniae, 20 parts, Fructus Jujubae, Fructus Lycii 20 parts.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of breast cancers, and the form of Chinese drug of described Chinese medicine composition is that sweet preparation method of refining pill comprises:
A, to get Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii put into juice extractor, remove slag → get fruit juice → mixing for standby use respectively;
B, by formula proportion, the surplus stock medicine except Fructus Citri tangerinae, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 1-2 hour, removes supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use;
C, medicinal residues are soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, adds fruit juice for subsequent use, and 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape;
D, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of breast cancers, and the form of Chinese drug of described Chinese medicine composition is that the preparation method of soup potus comprises:
A, to get Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii put into juice extractor, remove slag → get fruit juice → mixing for standby use respectively;
B, will except Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, surplus stock medicine beyond Fructus Lycii is mixed in proportion, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, first time decocts 2 ~ 4 hours after boiling, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boil rear slow fire, second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, centrifugal 30 minutes ~ 1 hour, extract supernatant and add fruit juice mixt for subsequent use, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtain soup potus.
beneficial effect of the present invention:
The present invention is Chinese medicine preparation; giving consideration to both the incidental and fundamental; medication is gentle; there is warming YANG and strengthening body resistance, effect that dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, hard masses softening and resolving supplement vigour; flowers and fruits are used as medicine; make its mouthfeel good; also not losing the property of medicine and drug effect, by coordinating traditional western medical treatment, thus can effectively spread by anticancer; better improve patients symptomatic; alleviate or suppress General Symptoms to react, protect each tract function, improving the effective percentage for the treatment of breast cancers, alleviate toxic and side effects; extend life cycle, reduce mortality.
detailed description of the invention:
embodiment 1, formula:radix Salviae Miltiorrhizae 20g, Cortex Moutan 20g, Flos Chrysanthemi 20g, Flos Carthami 20g, Semen Sinapis Albae 20g, Herba Verbenae 20g, Cortex Moutan 20g, Radix Actinidiae Chinensis 20g, Pedicellus et Pericarpium Trapae 20g, Semen Ciceris Arietini 20g, Hirudo 20g, Cutis Bufonis 20g, Spica Prunellae 20g, Ganoderma 20g, Radix Berberidis 20g, Rhizoma Chuanxiong 15g, Semen Persicae 15g, Ramulus Cinnamomi 15g, Rhizoma Corydalis 15g, Folium Coicis 15g, Rhizoma Dioscoreae 15g, Radix Polygoni Multiflori 15g, Fructus Momordicae charantiae 15g, Fructus Mori 15g, Fructus Corni 15g, Carapax Et Plastrum Testudinis 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Rehmanniae Preparata 15g, Radix Angelicae Sinensis 15g, Aspongopus 15g, Fructus Citri tangerinae 15g, Fructus Citri Limoniae 15g, Fructus Jujubae 15g, Fructus Lycii 15g.
Preparation method:
A, to get Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii put into juice extractor, remove slag → get fruit juice → mixing for standby use respectively;
B, by formula proportion, the surplus stock medicine except Fructus Citri tangerinae, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 1-2 hour, removes supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use;
C, medicinal residues are soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, adds fruit juice for subsequent use, and 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape;
D, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.
Treatment model case: Wang's Mammary cancer two coerces distending pain, and irritability is easily hot-tempered, breast caking is as stone, and thin white fur of tongue, red tongue has petechia, wiry forceful pulse.Take Chinese medicine preparation warming YANG and strengthening body resistance of the present invention, dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, oral 6 balls, one day four times, warm water takes, and takes transference cure after two weeks, consolidates one month afterwards, and postoperative rehabilitation is fine, and cancerous cell does not spread so far.
embodiment 2, formula:radix Salviae Miltiorrhizae 22g, Cortex Moutan 22g, Flos Chrysanthemi 22g, Flos Carthami 22g, Semen Sinapis Albae 22g, Herba Verbenae 22g, Cortex Moutan 22g, Radix Actinidiae Chinensis 22g, Pedicellus et Pericarpium Trapae 22g, Semen Ciceris Arietini 22g, Hirudo 22g, Cutis Bufonis 22g, Spica Prunellae 22g, Ganoderma 22g, Radix Berberidis 22g, Rhizoma Chuanxiong 16g, Semen Persicae 16g, Ramulus Cinnamomi 16g, Rhizoma Corydalis 16g, Folium Coicis 16g, Rhizoma Dioscoreae 16g, Radix Polygoni Multiflori 16g, Fructus Momordicae charantiae 16g, Fructus Mori 16g, Fructus Corni 16g, Carapax Et Plastrum Testudinis 16g, Rhizoma Atractylodis Macrocephalae 16g, Radix Rehmanniae Preparata 16g, Radix Angelicae Sinensis 16g, Aspongopus 16g, Fructus Citri tangerinae 16g, Fructus Citri Limoniae 16g, Fructus Jujubae 16g, Fructus Lycii 16g.
Preparation method:
A, to get Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii put into juice extractor, remove slag → get fruit juice → mixing for standby use respectively;
B, will except Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, surplus stock medicine beyond Fructus Lycii is mixed in proportion, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, first time decocts 2 ~ 4 hours after boiling, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boil rear slow fire, second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, centrifugal 30 minutes ~ 1 hour, extract supernatant and add fruit juice mixt for subsequent use, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtain soup potus.
Treatment model case: certain 50 years old together, during breast carcinoma chemicotherapy, nausea and vomiting, did not have appetite, swelling of the breast lumps, as hard as flint, and what push away does not move, with soreness of the waist and knees, menoxenia, dysphoria with feverish sensation in the chest palms and soles, pale tongue without fur, thready pulse.Take Chinese medicine preparation warming YANG and strengthening body resistance of the present invention, dispersing the stagnated live-QI to relieve the stagnation of QI, Chong and Ren Meridians regulating, an oral potion, one day twice, take transference cure after two weeks, consolidate one month afterwards, reach clinical cure standard, rehabilitation is fine, and cancerous cell does not spread so far.
embodiment 3, formula:radix Salviae Miltiorrhizae 25g, Cortex Moutan 25g, Flos Chrysanthemi 25g, Flos Carthami 25g, Semen Sinapis Albae 25g, Herba Verbenae 25g, Cortex Moutan 25g, Radix Actinidiae Chinensis 25g, Pedicellus et Pericarpium Trapae 25g, Semen Ciceris Arietini 25g, Hirudo 25g, Cutis Bufonis 25g, Spica Prunellae 25g, Ganoderma 25g, Radix Berberidis 25g, Rhizoma Chuanxiong 20g, Semen Persicae 20g, Ramulus Cinnamomi 20g, Rhizoma Corydalis 20g, Folium Coicis 20g, Rhizoma Dioscoreae 20g, Radix Polygoni Multiflori 20g, Fructus Momordicae charantiae 20g, Fructus Mori 20g, Fructus Corni 20g, Carapax Et Plastrum Testudinis 20g, Rhizoma Atractylodis Macrocephalae 20g, Radix Rehmanniae Preparata 20g, Radix Angelicae Sinensis 20g, Aspongopus 20g, Fructus Citri tangerinae 20g, Fructus Citri Limoniae 20g, Fructus Jujubae 20g, Fructus Lycii 20g.
Preparation method:
A, to get Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii put into juice extractor, remove slag → get fruit juice → mixing for standby use respectively;
B, by formula proportion, the surplus stock medicine except Fructus Citri tangerinae, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 1-2 hour, removes supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use;
C, medicinal residues are soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, adds fruit juice for subsequent use, and 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape;
D, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.
Treatment model case: during Wang's breast cancers chemicotherapy, nausea and vomiting, slight fever, breast caking increases fast, diabrosis, and shape is as mountain rock, and the likeness in form seedpod of the lotus, retracted nipple, deep red tongue, shells in tongue, soft and rapid pulse.Oral Chinese medicine preparation heat-clearing and toxic substances removing of the present invention and warming YANG and strengthening body resistance are also executed, oral 6 balls, and one day four times, warm water takes, and takes transference cure after 1 month, consolidate one month afterwards, clinically reach criterion of cure, and rehabilitation is fine, and cancerous cell does not spread so far.
embodiment 4, formula:radix Salviae Miltiorrhizae 28g, Cortex Moutan 28g, Flos Chrysanthemi 28g, Flos Carthami 28g, Semen Sinapis Albae 28g, Herba Verbenae 28g, Cortex Moutan 28g, Radix Actinidiae Chinensis 28g, Pedicellus et Pericarpium Trapae 28g, Semen Ciceris Arietini 28g, Hirudo 28g, Cutis Bufonis 28g, Spica Prunellae 28g, Ganoderma 28g, Radix Berberidis 28g, Rhizoma Chuanxiong 22g, Semen Persicae 22g, Ramulus Cinnamomi 22g, Rhizoma Corydalis 22g, Folium Coicis 22g, Rhizoma Dioscoreae 22g, Radix Polygoni Multiflori 22g, Fructus Momordicae charantiae 22g, Fructus Mori 22g, Fructus Corni 22g, Carapax Et Plastrum Testudinis 22g, Rhizoma Atractylodis Macrocephalae 22g, Radix Rehmanniae Preparata 22g, Radix Angelicae Sinensis 22g, Aspongopus 22g, Fructus Citri tangerinae 22g, Fructus Citri Limoniae 22g, Fructus Jujubae 22g, Fructus Lycii 22g.
Preparation method:
A, to get Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii put into juice extractor, remove slag → get fruit juice → mixing for standby use respectively;
B, will except Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, surplus stock medicine beyond Fructus Lycii is mixed in proportion, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, first time decocts 2 ~ 4 hours after boiling, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boil rear slow fire, second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, centrifugal 30 minutes ~ 1 hour, extract supernatant and add fruit juice mixt for subsequent use, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtain soup potus.
Treatment model case: the postoperative people of Liu's breast cancers feels dizziness and tinnitus, emaciated physique, dysphoria with feverish sensation in the chest palms and soles, pale complexion, uneasy sleeping at night, breast caking fester, color purple is dim, time stream sewage, foul smell is unpleasant, crimson tongue without fur, and pulse condition is unable.Take Chinese medicine preparation warming YANG and strengthening body resistance of the present invention, benefiting qi and nourishing blood.An oral potion, one day twice, takes transference cure after two weeks, consolidates one month afterwards, and reach clinical cure standard, rehabilitation is fine, and cancerous cell does not spread so far.
embodiment 5, formula:radix Salviae Miltiorrhizae 30g, Cortex Moutan 30g, Flos Chrysanthemi 30g, Flos Carthami 30g, Semen Sinapis Albae 30g, Herba Verbenae 30g, Cortex Moutan 30g, Radix Actinidiae Chinensis 30g, Pedicellus et Pericarpium Trapae 30g, Semen Ciceris Arietini 30g, Hirudo 30g, Cutis Bufonis 30g, Spica Prunellae 30g, Ganoderma 30g, Radix Berberidis 30g, Rhizoma Chuanxiong 25g, Semen Persicae 25g, Ramulus Cinnamomi 25g, Rhizoma Corydalis 25g, Folium Coicis 25g, Rhizoma Dioscoreae 25g, Radix Polygoni Multiflori 25g, Fructus Momordicae charantiae 25g, Fructus Mori 25g, Fructus Corni 25g, Carapax Et Plastrum Testudinis 25g, Rhizoma Atractylodis Macrocephalae 25g, Radix Rehmanniae Preparata 25g, Radix Angelicae Sinensis 25g, Aspongopus 25g, Fructus Citri tangerinae 25g, Fructus Citri Limoniae 25g, Fructus Jujubae 25g, Fructus Lycii 25g.
Preparation method:
A, to get Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii put into juice extractor, remove slag → get fruit juice → mixing for standby use respectively;
B, by formula proportion, the surplus stock medicine except Fructus Citri tangerinae, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 1-2 hour, removes supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use;
C, medicinal residues are soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, adds fruit juice for subsequent use, and 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape;
D, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.
Treatment model case: Zhang patient's breast carcinoma deficiency of qi and blood in late period, shortness of breath and palpitation, pale complexion, the shape body that disappears is thin, spiritlessness and weakness, anorexia, and lump in breast festers and spreads, and wound color is purple dark, and sewage taste is smelly, light red tongue or deep red, thin fur, deep,thready and forceless pulse.Oral Chinese medicine preparation harmonizing the liver and spleen of the present invention, benefiting qi and nourishing blood, oral 6 balls, one day four times, warm water takes, and takes transference cure after 1 month, adheres to taking invention formulation one month, cancerous cell is controlled, and adhere to every day so far over 3 years taking pill of the present invention, cancerous cell does not spread.
pharmacology pharmacodynamic is tested:
1, acute toxicity test
Application mice carries out acute toxicity testing and shows: Mouse oral gavage Chinese medicine preparation soup of the present invention potus, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Chinese medicine preparation of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.
, long term toxicity test
Select SD rat, give the Chinese medicine preparation pill of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
, animal local excitation test:
The allergic reaction on guinea pigs of injection of the present invention and honey refining pill Rat-rectum medication irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.
clinical data
1.1 physical data choose patient 100 example being diagnosed as breast cancers altogether, random digits table is adopted to be divided into treatment group and matched group at random, two groups of each 50 examples, to two groups of ages through statistical procedures, no significant difference (P>0.05).
1.2 diagnostic criteria
1.2.1 Western medicine diagnose standard is drafted with reference to " new Chinese medicine guideline of clinical investigations ".
1.2.2 the traditional Chinese medical science " breast carcinoma " demonstrate,proves diagnostic criteria.
1.3 case inclusive criterias are all to be met two doctor's diagnostic criterias and TCM Syndrome Type diagnostic criteria and outside exclusion standard, all can be used as and include case in.Participate in experimenter and all sign Informed Consent Form.
1.4 case exclusion standards (1) have other complication to affect the treatment to observe or have the disease of taboo to observing medicine.(2) other organ serious diseases person that needs medication treatment is had.(3) not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person.
2 Therapeutic Method
2.1 treatment groups give oral Chinese medicine preparation of the present invention.
2.2 matched groups are to giving liquid resuscitation, using antibiotic to control.
3 observation of curative effect
3.1 observation item tcm syndromes observe weekly its change.
3.2 effect criterion are divided into four grade standards (1) clinical recovery.(2) effective.(3) effective.(4) invalid.
3.3 statistical procedures all data acquisition SPSS12.0 statistical software adds up.
3.4 therapeutic outcomes are in Table
A table 1 liang group total effective rate compares (example)
Group n Recovery from illness Effective Effectively Invalid Total effective rate (%)
Treatment group 50 34 11 2 3 94
Matched group 50 26 12 5 7 86
In addition, in treatment group, final 2 examples are dead, and in matched group, final 6 examples are dead, as can be seen from Table 1, adopt Chinese medicine preparation of the present invention can improve overall treatment effect to breast cancers, reduce mortality, treatment group is compared with matched group, and P<0.05, has comparability.
A table 2 liang group Chinese medicine syndrome integral compares (x ± s, point)
Group n Before treatment After treatment
Treatment group 50 25.21±2.5 11.81±2.42
Matched group 50 24.41±1.34 12.51±2.54
Table 2 statistical analysis is pointed out: treat front two groups of integration no significant difference, after treatment, two groups of integrations are compared with before treatment, difference all has statistical significance (P<0.01), two groups of integral contrasts after treatment, difference has statistical significance (P<0.05).
After table 3 liang organizes 1 year, relapse rate compares (example)
Group n Recurrence Recovery from illness Relapse rate (%)
Treatment group 50 5 45 10
Matched group 50 9 41 18
Table 3 statistical analysis is pointed out: treatment group relapse rate compares with matched group, and difference has statistical significance (P<0.05).
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (5)

1. treat a Chinese medicine composition for breast cancers, it is characterized in that: in described Chinese medicine composition, the ratio of weight and number of various crude drug is:
Radix Salviae Miltiorrhizae 20-30 part, Cortex Moutan 20-30 part, Flos Chrysanthemi 20-30 part, Flos Carthami 20-30 part, Semen Sinapis Albae 20-30 part, Herba Verbenae 20-30 part, Cortex Moutan 20-30 part, Radix Actinidiae Chinensis 20-30 part, Pedicellus et Pericarpium Trapae 20-30 part, Semen Ciceris Arietini 20-30 part, Hirudo 20-30 part, Cutis Bufonis 20-30 part, Spica Prunellae 20-30 part, Ganoderma 20-30 part, Radix Berberidis 20-30 part, Rhizoma Chuanxiong 15-25 part, Semen Persicae 15-25 part, Ramulus Cinnamomi 15-25 part, Rhizoma Corydalis 15-25 part, Folium Coicis 15-25 part, Rhizoma Dioscoreae 15-25 part, Radix Polygoni Multiflori 15-25 part, Fructus Momordicae charantiae 15-25 part, Fructus Mori 15-25 part, Fructus Corni 15-25 part, Carapax Et Plastrum Testudinis 15-25 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Radix Rehmanniae Preparata 15-25 part, Radix Angelicae Sinensis 15-25 part, Aspongopus 15-25 part, Fructus Citri tangerinae 15-25 part, Fructus Citri Limoniae 15-25 part, Fructus Jujubae 15-25 part, Fructus Lycii 15-25 part.
2. a kind of Chinese medicine composition for the treatment of breast cancers according to claim 1, is characterized in that: the ratio of weight and number of various crude drug also can be:
Radix Salviae Miltiorrhizae 22-28 part, Cortex Moutan 22-28 part, Flos Chrysanthemi 22-28 part, Flos Carthami 22-28 part, Semen Sinapis Albae 22-28 part, Herba Verbenae 22-28 part, Cortex Moutan 22-28 part, Radix Actinidiae Chinensis 22-28 part, Pedicellus et Pericarpium Trapae 22-28 part, Semen Ciceris Arietini 22-28 part, Hirudo 22-28 part, Cutis Bufonis 22-28 part, Spica Prunellae 22-28 part, Ganoderma 22-28 part, Radix Berberidis 22-28 part, Rhizoma Chuanxiong 16-22 part, Semen Persicae 16-22 part, Ramulus Cinnamomi 16-22 part, Rhizoma Corydalis 16-22 part, Folium Coicis 16-22 part, Rhizoma Dioscoreae 16-22 part, Radix Polygoni Multiflori 16-22 part, Fructus Momordicae charantiae 16-22 part, Fructus Mori 16-22 part, Fructus Corni 16-22 part, Carapax Et Plastrum Testudinis 16-22 part, Rhizoma Atractylodis Macrocephalae 16-22 part, Radix Rehmanniae Preparata 16-22 part, Radix Angelicae Sinensis 16-22 part, Aspongopus 16-22 part, Fructus Citri tangerinae 16-22 part, Fructus Citri Limoniae 16-22 part, Fructus Jujubae 16-22 part, Fructus Lycii 16-22 part.
3. a kind of Chinese medicine composition for the treatment of breast cancers according to claim 1, is characterized in that: the ratio of weight and number of various crude drug can also be:
Radix Salviae Miltiorrhizae 25 parts, Cortex Moutan 25 parts, Flos Chrysanthemi 25 parts, 25 parts, Flos Carthami, Semen Sinapis Albae 25 parts, Herba Verbenae 25 parts, Cortex Moutan 25 parts, Radix Actinidiae Chinensis 25 parts, Pedicellus et Pericarpium Trapae 25 parts, Semen Ciceris Arietini 25 parts, Hirudo 25 parts, Cutis Bufonis 25 parts, Spica Prunellae 25 parts, Ganoderma 25 parts, Radix Berberidis 25 parts, Rhizoma Chuanxiong 20 parts, 20 parts, Semen Persicae, Ramulus Cinnamomi 20 parts, Rhizoma Corydalis 20 parts, Folium Coicis 20 parts, Rhizoma Dioscoreae 20 parts, Radix Polygoni Multiflori 20 parts, 20 parts, Fructus Momordicae charantiae, 20 parts, Fructus Mori, Fructus Corni 20 parts, Carapax Et Plastrum Testudinis 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Rehmanniae Preparata 20 parts, Radix Angelicae Sinensis 20 parts, Aspongopus 20 parts, Fructus Citri tangerinae 20 parts, 20 parts, Fructus Citri Limoniae, 20 parts, Fructus Jujubae, Fructus Lycii 20 parts.
4. a kind of Chinese medicine composition for the treatment of breast cancers according to claim 1-3 any one, is characterized in that: form of Chinese drug is that the preparation method of honey refining pill comprises:
A, to get Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii put into juice extractor, remove slag → get fruit juice → mixing for standby use respectively;
B, by formula proportion, the surplus stock medicine except Fructus Citri tangerinae, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 1-2 hour, removes supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use;
C, medicinal residues are soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, adds fruit juice for subsequent use, and 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape;
D, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.
5. a kind of Chinese medicine composition for the treatment of breast cancers according to claim 1-3 any one, is characterized in that: form of Chinese drug is that the preparation method of soup potus comprises:
A, to get Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, Fructus Lycii put into juice extractor, remove slag → get fruit juice → mixing for standby use respectively;
B, will except Fructus Citri tangerinae by formula proportion, Fructus Citri Limoniae, Fructus Jujubae, surplus stock medicine beyond Fructus Lycii is mixed in proportion, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, first time decocts 2 ~ 4 hours after boiling, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boil rear slow fire, second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, centrifugal 30 minutes ~ 1 hour, extract supernatant and add fruit juice mixt for subsequent use, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtain soup potus.
CN201510311019.2A 2015-06-09 2015-06-09 Traditional Chinese medicine composition for treating breast cancer Pending CN104857370A (en)

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