CN105381414A - Traditional Chinese medicine preparation for treating breast lumps and cystic hyperplasia and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for treating breast lumps and cystic hyperplasia and preparation method thereof Download PDF

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Publication number
CN105381414A
CN105381414A CN201510976805.4A CN201510976805A CN105381414A CN 105381414 A CN105381414 A CN 105381414A CN 201510976805 A CN201510976805 A CN 201510976805A CN 105381414 A CN105381414 A CN 105381414A
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China
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radix
preparation
chinese medicine
fructus
breast
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CN201510976805.4A
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不公告发明人
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Qingdao You Cheng New And High Technology Co Ltd
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Qingdao You Cheng New And High Technology Co Ltd
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating breast lumps and cystic hyperplasia. The traditional Chinese medicine preparation is prepared from all-grass of Japanese violets, a longhairy antenoron herb, rhizoma coptidis, fresh ramie roots, green tangerine peels, fructus forsythiae, honeysuckles, dandelion, burdocks, platycodon grandiflorum, radix angelica sinensis, pseudo-ginsengs, radix angelicae, radix astragali, Chinese rhubarb, ligusticum chuanxiong hort, concha arcae, Chinese wolfberry fruits, licorice, prepared fleece flower roots, Chinese dates, poria cocos and the like. Compared with the prior art, the traditional Chinese medicine preparation has the advantages of being good in curative effect, low in cost, small in limitation, free of adverse reaction and the like. The traditional Chinese medicine composition is simple in production process, safe in use, stable, reliable and good in curative effect and is an effective medicine for treatment of the breast lumps and the cystic hyperplasia. Compared with the like drugs, the traditional Chinese medicine preparation has the advantages of being rigorous in compatibility, moderate in medicine properties and remarkable in curative effect and facilitates large-area clinical popularization and application.

Description

A kind ofly treat Chinese medicine preparation of lump in breast and cystic hyperplasia and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to a kind ofly treat Chinese medicine preparation of lump in breast and cystic hyperplasia and preparation method thereof.
Background technology
Lump in breast is the common clinical manifestation of mastopathy.Because the factors such as endocrine disturbance, for a long time psychentonia are depressed, dietary structure is unreasonable cause modern female breast lump incidence rate greatly to increase compared with before the eighties; From anatomic angle, lump in breast makes interior minister have a kind of disease of lump because of the structural change of breast tissue.Lump in breast mainly comprises: 1. mammary gland fibroadenoma; 2. cyclomastopathy; 3. mastitis; 4. mammary gland amass newborn pus swell; 5. breast carcinoma.Except breast carcinoma be pernicious except, all the other lumps all belong to optimum.
Treatment as breast carcinoma has Canonical management method both at home and abroad at present, and for breast benign lesion, at present except small part need be performed the operation, the overwhelming majority can adopt oral medicinal herb or external application for curing, with alleviating pain, reduces until eliminate lump.But because endo-medicine is as RUPIXIAO, RUKUAIXIAO etc., long-term taking is not easily adhered to comparatively greatly gastrointestinal irritation, and costly.So adopt the method for the external application of Chinese medicine can avoid these problems above.
Summary of the invention
In order to overcome deficiency of the prior art, the invention provides a kind of Chinese medicine preparation for the treatment of lump in breast and cystic hyperplasia.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Chinese medicine preparation for the treatment of lump in breast and cystic hyperplasia, is made up of each component of following parts by weight:
Herba Violae japonicae 1-30 part, Herba Lysimachiae 1-30 part, Rhizoma Coptidis 1-30 part, fresh Radix Boehmeriae 1-30 part, Pericarpium Citri Reticulatae Viride 1-30 part, Fructus Forsythiae 1-30 part, Flos Lonicerae 1-30 part, Herba Taraxaci 1-30 part, Fructus Arctii 1-30 part, Radix Platycodonis 1-30 part, Radix Angelicae Sinensis 1-30 part, Radix Notoginseng 1-30 part, Radix Angelicae Dahuricae 1-30 part, Radix Astragali 1-30 part, Radix Et Rhizoma Rhei 1-30 part, Rhizoma Chuanxiong 1-30 part, Concha Arcae 1-30 part, Fructus Lycii 1-30 part, Radix Glycyrrhizae 1-30 part, Radix Polygoni Multiflori Preparata 1-30 part, Fructus Jujubae 1-30 part, Poria 1-30 part, Myrrha 1-30 part, Rhizoma Curcumae 1-30 part, Radix Trichosanthis 1-30 part, Caulis Spatholobi 1-30 part, Fructus Trichosanthis 1-30 part, Periostracum Cicadae 1-30 part, Pheretima 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Radix Dipsaci 1-30 part, soybean isoflavone 1-30 part, Flos Rosae Rugosae 1-30 part, Semen Cassiae 1-30 part, Flos Carthami 1-30 part, Fructus Akebiae 1-30 part.
The Chinese medicine preparation of described treatment lump in breast and cystic hyperplasia, in Chinese medicine preparation described in it, the parts by weight of various crude drug can be preferably:
Herba Violae japonicae 10-30 part, Herba Lysimachiae 5-30 part, Rhizoma Coptidis 5-30 part, fresh Radix Boehmeriae 5-30 part, Pericarpium Citri Reticulatae Viride 5-30 part, Fructus Forsythiae 5-30 part, Flos Lonicerae 5-30 part, Herba Taraxaci 5-30 part, Fructus Arctii 5-30 part, Radix Platycodonis 5-30 part, Radix Angelicae Sinensis 5-30 part, Radix Notoginseng 5-30 part, Radix Angelicae Dahuricae 5-30 part, Radix Astragali 5-30 part, Radix Et Rhizoma Rhei 5-30 part, Rhizoma Chuanxiong 5-30 part, Concha Arcae 5-30 part, Fructus Lycii 5-30 part, Radix Glycyrrhizae 1-30 part, Radix Polygoni Multiflori Preparata 1-30 part, Fructus Jujubae 1-30 part, Poria 1-30 part, Myrrha 1-30 part, Rhizoma Curcumae 1-30 part, Radix Trichosanthis 1-30 part, Caulis Spatholobi 1-30 part, Fructus Trichosanthis 1-30 part, Periostracum Cicadae 1-30 part, Pheretima 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Radix Dipsaci 1-30 part, soybean isoflavone 1-30 part, Flos Rosae Rugosae 1-30 part, Semen Cassiae 1-30 part, Flos Carthami 1-30 part, Fructus Akebiae 1-30 part.
The Chinese medicine preparation of described treatment lump in breast and cystic hyperplasia, in Chinese medicine preparation described in it, the parts by weight of various crude drug can also be preferably:
Herba Violae japonicae 10-30 part, Herba Lysimachiae 5-30 part, Rhizoma Coptidis 5-30 part, fresh Radix Boehmeriae 5-30 part, Pericarpium Citri Reticulatae Viride 5-30 part, Fructus Forsythiae 5-30 part, Flos Lonicerae 5-30 part, Herba Taraxaci 5-30 part, Fructus Arctii 5-30 part, Radix Platycodonis 5-30 part, Radix Angelicae Sinensis 5-30 part, Radix Notoginseng 5-30 part, Radix Angelicae Dahuricae 5-30 part, Radix Astragali 5-30 part, Radix Et Rhizoma Rhei 5-30 part, Rhizoma Chuanxiong 5-30 part, Concha Arcae 5-30 part, Fructus Lycii 5-30 part, Radix Glycyrrhizae 10-30 part, Radix Polygoni Multiflori Preparata 10-30 part, Fructus Jujubae 10-30 part, Poria 10-30 part, Myrrha 10-30 part, Rhizoma Curcumae 10-30 part, Radix Trichosanthis 10-30 part, Caulis Spatholobi 10-30 part, Fructus Trichosanthis 10-30 part, Periostracum Cicadae 10-30 part, Pheretima 10-30 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Dipsaci 10-30 part, soybean isoflavone 10-30 part, Flos Rosae Rugosae 10-30 part, Semen Cassiae 10-30 part, Flos Carthami 10-30 part, Fructus Akebiae 10-30 part.
The Chinese medicine preparation of described treatment lump in breast and cystic hyperplasia, the dosage form of described Chinese medicine preparation is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.
For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine preparation for the treatment of lump in breast and cystic hyperplasia, and the dosage form of described endo-medicine is pill, and its preparation process comprises:
A. described crude drug is mixed, chopping, cross 120 mesh sieves, obtain thin medicated powder for subsequent use;
B. unsifted coarse powder is soaked in ethanol and extract 2 times;
C. the medicinal residues after above-mentioned steps extraction are got again, the heating and refluxing extraction that adds water 2 times;
D. merged by above-mentioned two kinds of extracting solution, decompression recycling ethanol becomes extractum, obtains thin medicated powder merge and add Mel and be twisted into pill with a step.
In described step b, get raw material to add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-180 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating is concentrated, stand for standby use.
In described step c, 10 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, and each extraction time is 1 ~ 2 hour, 100-120 order filters, use aperture at 1000um again, molecular cut off, in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolates the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.14, and heating is concentrated, stand for standby use.
For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine preparation for the treatment of lump in breast and cystic hyperplasia, and described preparation formulation is capsule, comprising of its preparation method:
A. described raw material is put into pulverizer grinding and sieving;
B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;
C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 1 time;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine preparation for the treatment of lump in breast and cystic hyperplasia, and described preparation formulation is oral solutions, comprising of its preparation method:
A, get raw material and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;
B, medicinal residues water extraction 2 times, thickening filtration is paste, is component 2;
C, above-mentioned two kinds of pastes are condensed into pasty state, sterilizing, add dextrin, then vacuum freezing sealing.
In described step c, above-mentioned two kinds of component pastes are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, then vacuum canning sealing and get final product, and directly drinks during use.
The present invention has the advantages such as good effect, cost is low, limitation is little, have no adverse reaction relative to prior art.Chinese medicine composition production technology of the present invention is simple, and drug safety is reliable and stable, good effect, is the active drug for the treatment of lump in breast and cystic hyperplasia.Compare with similar drugs, it is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, is convenient to large scale application clinically.
Detailed description of the invention
The present invention adopts pure Chinese medicinal preparation, safety non-pollution, meets clinical practice.
In the present invention:
Herba Violae japonicae: nature and flavor: bitter in the mouth; Micro-pungent; Cold in nature.Gui Jing: liver; Spleen channel.Function cures mainly: heat-clearing and toxic substances removing; Blood stasis dispelling evacuation of pus; Removing heat from blood liver heat removing.Main swollen ulcer drug; Acute mastitis; Acute appendicitis hematochezia; Suppurative osteomyelitis; Jaundice; Conjunctival congestion and swelling pain; Scrofula; Traumatic hemorrhage; Snakebite.
Herba Lysimachiae: nature and flavor: toil is cool.1. " detailed outline is picked up any lost article from the road ": " taste is micro-sweet, cold nature." 2. " south of the Five Ridges gather medicinal herbs record ": " puckery, gas is fragrant, and property is put down." 3. " modern Practical Chinese medicinal ": " is bitter, cold." function cures mainly: heat clearing away, diuresis, antitussive, detumescence, removing toxic substances.Harness the Yellow River subcutaneous ulcer, edema, vesical calculus, malaria, lung abscess, cough, spits blood, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, infantile malnutrition, infantile convulsion, carbuncle, skin ulcer tinea, eczema.
Rhizoma Coptidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
Fresh Radix Boehmeriae: nature and flavor: sweet, cold.1. " not Lu ": " cold." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " Japan hanako materia medica ": " sweet in the mouth is sliding, cold, nontoxic." 4. " Zhejiang traditional herbal medicine ": " is cold in nature, and sour in the mouth is nontoxic." return through: 1. " must join book on Chinese herbal medicine ": " enters meridian of Foot-JUE YIN blood system." 2. " book on Chinese herbal medicine brief points ": " staff, meridian of Foot-TAI YIN." function cures mainly: heat clearing away, hemostasis, removing toxic substances, dissipating blood stasis.Control calentura extreme thirst, mad greatly, stranguria with blood, the difficulty in urination, spit blood, hematochezia, leucorrhea with red and white discharge, erysipelas, carbuncle, traumatic injury, snake bite and insect sting.
Pericarpium Citri Reticulatae Viride: nature and flavor: toil, tepor. 1. " Bencao Tujing ": " bitter in the mouth." 2. " medicine origin ": " temperature, acrid in the mouth." curing mainly secret formula " cloud, cold in nature, bitter in the mouth.The pungent micro-acid of " 3. " about can cure mirror ": " bitter in the mouth." return through: enter liver, gallbladder meridian. 1. Li Gao: " foot faints the guiding drug of the moon, shaoyang channel." 2. Materia Medica of Decoction: " meridian of Foot-JUE YIN guiding drug, enters meridian of Hand-SHAO YANG again." 3. " Thunder God concocts property of medicine solution ": " enters liver, spleen two warp." 4. " book on Chinese herbal medicine is through separating ": " enters liver channel of foot-Jueyin, lung meridian, heart channel of Hand-Shaoyin." function cures mainly: soothing the liver dispelling the stagnated QI, eliminating stagnation expectorant.Control breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, chronic malaria addiction block.1. " Bencao Tujing ": " the main stagnation of QI, lower food, removing mass knot and diaphragm gas." 2. " medicine origin ": " " curing mainly secret formula " cloud, dividing of the moon of fainting, few sun illly uses it.Broken hard addiction, loose stagnant gas, go the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels all wet, left flank has pneumatosis." 3. " detailed outline ": " controls chest and diaphragm QI rising in reverse order, hypochondriac pain, lower abdomen hernia, and disappear swelling of the breast, soothing the liver gallbladder, eliminating the pathogens from the lung gas." 4. essentials of Matea Medica: " expectorant disappears painful abdominal mass, controls depression of liver-QI, the many anger of hypochondriac pain, chronic malaria knot addiction, colic, swelling of the breast." 5. " modern Practical Chinese medicinal ": " treats for stomachache, and tells inverse, antipyretic, expectorant water."
Fructus Forsythiae: nature and flavor: bitter, is slightly cold.Gui Jing: return lung, the heart, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.
Flos Lonicerae: nature and flavor: sweet, cold.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold in nature, bitter in the mouth." 2. " book on Chinese herbal medicine just ": " sweet in the mouth, gas is put down, its cold nature." return through: enter lung, stomach warp.1. " Thunder God concocts property of medicine solution ": " enter lung meridian." 2. " must join book on Chinese herbal medicine ": " enters bright, the Taiyin channels of foot sun." function cures mainly: heat clearing away, removing toxic substances.Control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " heat clearing away, separates all skin ulcers, carbuncle carbuncle on the back, red stream scrofula." 2. " the SHENGCAO property of medicine is standby to be wanted "; " energy eliminating carbuncle cellulitis furunculosis, dysentery relieving disease, washes chancre, peeling skin heat in blood."
Herba Taraxaci: nature and flavor: bitter sweet, cold.1. Tang Materia Medica: " sweet in the mouth is flat, nontoxic." 2. Li Gao: " micro-hardship, cold." 3. " book on Chinese herbal medicine is stated ": " is sweet, puts down and is slightly cold." 4. Guangzhou army " conventional Chinese herbal medicine handbook ": " is bitter sweet, cold." return through: enter liver, stomach warp.1. Li Gao: " meridian of Foot-SHAO YIN." 2. " Amplification on Materia Medica addendum ": " enters bright, the Taiyin channels of sun." function cures mainly: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.
Fructus Arctii: nature and flavor: bitter sweet, cold.1. Tang Materia Medica: " sweet in the mouth is flat, nontoxic." 2. Li Gao: " micro-hardship, cold." 3. " book on Chinese herbal medicine is stated ": " is sweet, puts down and is slightly cold." 4. Guangzhou army " conventional Chinese herbal medicine handbook ": " is bitter sweet, cold." return through: enter liver, stomach warp.1. Li Gao: " meridian of Foot-SHAO YIN." 2. " amplification on Materia Medicaaddendum ": " enter bright, the Taiyin channels of sun." function cures mainly: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.
Radix Platycodonis: nature and flavor: toil is flat.1. " herbal classic ": " pungent, tepor." 2. " not Lu ": " be bitter, slightly poisonous." 3. " property of medicine opinion ": " is bitter, flat, nontoxic." return through: enter lung, stomach warp.1. Materia Medica of Decoction: " enter the few the moon of foot, hands is lunar." 2. " product remittance essence is wanted ": " row meridian of Foot-TAI YIN." 3. " Bencao Jingshu ": " starts with lunar, few cloudy, double enter the stomach channel of foot-Yang-ming." function cures mainly: open lung qi dispersing gas, evacuation of pus of eliminating the phlegm.Control exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery is suffered from abdominal pain.1. " herbal classic ": " main chest and hypochondrium is as lancination, and abdominal distention, borborygmus are faint, gas of throbbing with fear in terror." 2. " not Lu ": " sharp the five internal organs the intestines and stomach, gas of enriching blood, except cold and heat, migratory arthralgia, warming middle-JIAO rapid digestion of food, treats laryngopharynx pain." 3. " property of medicine opinion ": " controls the inferior dysentery, removing blood stasis, removes pneumatosis, and removing food stagnancy gathers, sputum, and main lung-heat tachypnea is coughed inverse, except cold type of pain in abdomen, and main attacked by pestiferous factors and pediatric epilepsy scared." 4. " Japan hanako materia medica ": " all gas lower, only cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, mend five kinds of over strain, foster the spirit of nobility, evil removing wards off temperature, tonify deficiency expectorant, broken lump in the abdomen, and evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat."
Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Notoginseng: nature and flavor: sweet, micro-hardship, temperature.Gui Jing: return liver, stomach warp.Function cures mainly: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.
The Radix Angelicae Dahuricae: nature and flavor: pungent, temperature.1. " herbal classic ": " pungent, temperature." 2. " not Lu ": " be nontoxic." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " is warm in nature, and acrid in the mouth is micro-sweet." 4. " medicine figure examines ": " is slightly poisonous, smelly perfume (or spice), acrid in the mouth." return through: enter lung, thigh, stomach warp.1. " pearl sac ": " stomach of foot Yang Ming, hands sun bright large intestine, lung meridian." 2. " Thunder God concocts property of medicine solution ": " enters lung, spleen, stomach three warp." 3. " book on Chinese herbal medicine is through separating ": " enters liver channel of foot-Jueyin, the stomach channel of foot-Yang-ming, the large intesting channel of Hand-Yangming." function cures mainly: dispel the wind, dampness, detumescence, pain relieving.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.
The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Et Rhizoma Rhei: nature and flavor: bitter, cold.Gui Jing: return spleen, stomach, large intestine, liver, pericardium channel.Function cures mainly: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.
Rhizoma Chuanxiong: nature and flavor: pungent, temperature.1. " herbal classic ": " acrid in the mouth, temperature." 2. " WU Pu Bencao ": " Yellow Emperor, a legendary ruler, qi primary, Thunder God: pungent, nontoxic are fragrant.Bian Que: acid, nontoxic.Li Shi: raw temperature, ripe cold." 3. Tang Materia Medica: " bitter in the mouth is pungent." 4. " book on Chinese herbal medicine just ": " acrid in the mouth is micro-sweet, temperature." return through: enter liver, gallbladder meridian.1. Materia Medica of Decoction: " meridian of Foot-JUE YIN of starting with, shaoyang channel." 2. " medicineization justice ": " enters liver, spleen, three burnt three warps." function cures mainly: activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Concha Arcae: nature and flavor: Gan Xian is flat.1. " book on Chinese herbal medicine covers bamboo fish trap ": " salty in the mouth, temperature is nontoxic." 2. " detailed outline ": " is sweet salty, flat, nontoxic." return through: enter liver, spleen channel.1. " book on Chinese herbal medicine is looked for the truth ": " enter liver." 2. " key medicine divides agent ": " enters late at night, lung, spleen channel." function cures mainly: reduce phlegm, softening the hard mass, dissipating blood stasis, removing food stagnancy.Control accumulation of phlegm, stomachache, noisy, acid regurgitation, lump in the abdomen, scrofula, ulcerative gingivitis.1. " Japan hanako materia medica ": " burnt quench in vinegar, vinegar ball takes, and controls all vim and vigour, cold air, disease addiction.The merit of " 2. " daily book on Chinese herbal medicine ": " expectorant is maximum, and all expectorant uses it every disease." 3. " danxi's experiential therapy ": " can disappear clot, secondary expectorant." 4. " detailed outline ": " connects meat charred medicinal herb with its property retained, grinds deposited children's's acute gangrenous stomatitis." 5. " medical center collection is wanted ": " removes all accumulation of phlegm, accumulation of blood, air parcel, and broken lump in the abdomen, attacks scrofula." 6. " modern Practical Chinese medicinal ": " for rickets of child, pulmonary tuberculosis, the diseases such as lymphoid tuberculosis."
Fructus Lycii: nature and flavor: sweet, flat.1. " not Lu ": " be slightly cold, nontoxic." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " Treatise on Dietetic Therapy ": " trembles with fear, nontoxic." return through: enter liver, kidney channel.1. " book on Chinese herbal medicine converges and says ": " enter few cloudy, the meridian of Foot-JUE YIN of foot." 2. " book on Chinese herbal medicine is through separating ": " enters kidney meridian, heart channel of Hand-Shaoyin." 3. " key medicine divides agent ": " enters liver, stomach two warp, double enter lung meridian." function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.1. TAO Hong-Jing: " nourishing the essence and strengthening QI, prosperous and powerful vagina." 2. " property of medicine opinion ": " energy tonification essence various symptoms and signs of deficiency, easy color, bleaches, and improving eyesight is calmed the nerves." 3. " Treatise on Dietetic Therapy ": " hard muscle is always resistance to, and except wind, tonification muscles and bones, the beneficial people of energy, removes asthenia." 4. Wang Haogu: " main cardiopathia dry sensation in the pharynx, pained, taking fluids profusely yearningly, during nephropathy disappears." 5. " detailed outline ": " nourishing kidney, lung moistening, improving eyesight."
Radix Glycyrrhizae: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Polygoni Multiflori Preparata: nature and flavor: bitter sweet puckery, tepor.1. " Radix Polygoni Multiflori record ": " sweet in the mouth, temperature, nontoxic." 2. " Kaibao Bencao ": " bitter and puckery flavor, tepor, nontoxic." 3. " book on Chinese herbal medicine converges and says ": " raw use gas is trembled with fear, and property is held back, poisonous; Make ripe temperature, nontoxic." return through: enter liver, kidney channel.1. " detailed outline ": " sufficient the moon of fainting, few the moon." 2. " book on Chinese herbal medicine is through separating ": " enters the Gallbladder Channel of Foot-Shaoyang, triple energizer meridian, heart channel of Hand-Shaoyin, kidney meridian." 3. " book on Chinese herbal medicine is new again ": " enters spleen, lung, kidney three warp." function cures mainly: tonifying liver, and kidney tonifying nourishes blood, and dispels the wind.Control hepatic and renal YIN deficiency, sending out must be early white, and blood deficiency is dizzy, and waist knee joint is weak, and muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.Radix Polygoni Multiflori Preparata invigorating the liver and kidney, benefiting essence-blood, black beard and hair, strengthening bone and muscle; For vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, neurasthenia, hyperlipidemia.
Fructus Jujubae: nature and flavor: sweet, temperature.1. " herbal classic ": " sweet in the mouth is flat.' 2. " a thousand pieces of gold dietetic therapy ": " sweet in the mouth is pungent, heat, nontoxic." 3. the Meng numerous: " temperature." return through: enter spleen, stomach warp.1. " detailed outline ": " spleen channel blood system.It is lunar that " 2. " Bencao Jingshu ": " enters foot, Yangming Channel." function cures mainly: spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid, adjusts battalion to defend, separates poison of drug.Control insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation.Married woman's stolen goods are hot-tempered.
Poria: nature and flavor: sweet light is flat.1. " herbal classic ": " sweet in the mouth is flat." 2. " medicine origin ": " " curing mainly secret formula " cloud, warm in nature, lightly seasoned." return through: enter the heart, spleen, lung meridian.1. Materia Medica of Decoction: " start with large cloudy, the large sun of foot, shaoyang channel." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " enters bladder, kidney, lung." 3. " Thunder God concocts property of medicine solution ": " enters lung, spleen, small intestinal three warp.It is few cloudy that " 4. " Bencao Jingshu ": " enters brothers, the hands sun, lunar, the Yangming Channel of foot." function cures mainly: eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.1. " herbal classic ": " the inverse gas of the main breast side of body, melancholy is angerd frightened heresy and probably throbbed with fear, knot pain under the heart, cold and heat stuffy sensation with restlessness, cough with dyspnea, the burnt dry tongue of mouth, diuresis." 2. " not Lu ": " only quenches one's thirst, and likes to sleep, and large abdomen drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema drenches knot.Open breast internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, physical strength profiting, during guarantor god keeps."
Myrrha: nature and flavor: bitter is flat.1. " property of medicine opinion ": " bitter in the mouth is pungent." 2. " Haiyao Bencao, Oversea Materia Medica ": " bitter in the mouth is pungent, temperature, nontoxic." 3. " Kaibao Bencao ": " bitter in the mouth is flat, nontoxic." return through: enter Liver Channel.1. " Bencao Jingshu ": " enter meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine is newly organized ": " enters spleen, kidney two warp." 3. " book on Chinese herbal medicine is looked for the truth ": " enters the heart, liver." function cures mainly: loose blood blood stasis removing, subduing swelling and relieving pain.Control and fall damage, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye,
Rhizoma Curcumae: nature and flavor: acrid in the mouth; Bitter; Warm in nature.Gui Jing: return liver, spleen channel.Function cures mainly: circulation of qi promoting removing blood stasis; Removing food stagnancy pain relieving.Main vim and vigour are pained; Eating accumulation; Abdominal distention; Amenorrhea due to stagnation of blood; Dysmenorrhea; Lump in the abdomen tumor mass in the abdomen; Traumatic injury.
Radix Trichosanthis: nature and flavor: sweetness and bitterness acid is cool.1. " herbal classic ": " bitter in the mouth, cold." 2. " not Lu ": " be nontoxic." 3. " detailed outline ": " sweet micro-picric acid, is slightly cold." return through: enter lung, stomach warp.1. " Thunder God concocts property of medicine solution ": " enter lung, the heart, spleen, stomach, the small intestinal Five Classics." 2. " book on Chinese herbal medicine is through separating ": " enters kidney meridian, bladder meridian, heart channel of Hand-Shaoyin." function cures mainly: promote the production of body fluid, and quenches the thirst, and pathogenic fire reducing is moisturized, evacuation of pus, detumescence.Control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.1. " herbal classic ": " master quenches one's thirst, fever of the body, and stuffy sensation with restlessness is hot greatly, tonify deficiency regulating the spleen and stomach, continuous wound absolutely." 2. " not Lu ": ", except heat chronic in the intestines and stomach, eight subcutaneous ulcer body yellowish complexion, dry lip, dry mouth, loses heart.Logical moon water, only normal urination." 3. " Japan hanako materia medica ": " leads to small intestinal, evacuation of pus, and detumescence poison, granulation promoting is put on flesh, and disappears and flutters damage blood stasis.Disease when controlling fanatical, acute mastitis, carbuncle on the back, hemorrhoid complicated by anal fistula furuncle." 4. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controls carbuncle pyogenic infections from tumour or sore, the band blood and cough-relieving is coughed." 5. " book on Chinese herbal medicine covers bamboo fish trap ": " controls inclined hernia."
Caulis Spatholobi: nature and flavor: bitter sweet, temperature.1. " decoction pieces is newly joined ": " pained fragrant micro-sweet." 2. " book on Chinese herbal medicine justice ": " temperature." 3. Jiangxi " Chinese herbology ": " bitter temperature is micro-sweet." return through: " book on Chinese herbal medicine is new again ": " enters the heart, spleen two warp." function cures mainly: invigorate blood circulation, relaxing muscles and tendons.Control soreness of waist and knee joint, paralysis and numbness, menoxenia.1. " detailed outline is picked up any lost article from the road ": " invigorate blood circulation, warm waist knee joint, paralysis." 2. " book on Chinese herbal medicine is new again ": " dry stomach of invigorating middle warmer." 3. " decoction pieces is newly joined ": " blood stasis removing blood, tissue regeneration promoting blood, fluent passages through which vital energy circulates.Control summer filthy infection, wind arthralgia due to stagnation of blood disease.The hematonic that " 4. " modern Practical Chinese medicinal ": " is robustness, is applicable to anemicus neural paralysis disease, as limbs and soreness of waist and knee joint, apathetic etc.Again for menoxenia, menstruation apolipsis etc., have the effect of invigorating blood circulation analgesia."
Fructus Trichosanthis: nature and flavor: sweet, micro-hardship, cold.Gui Jing: return lung, stomach, large intestine channel.Function cures mainly: clearing away heat and eliminating phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.
Periostracum Cicadae: nature and flavor: Gan Xian is cool.1. " detailed outline ": " salty sweet, cold, nontoxic." 2. " book on Chinese herbal medicine just ": " taste is micro-sweet micro-salty, slightly cool in nature." 3. " king Chinese catalpa medicine solution ": " acrid in the mouth, gas is put down." return through: enter lung, Liver Channel.1. " Bencao Jingshu ": " enter liver." 2. " book on Chinese herbal medicine is new again ": " enters liver, spleen, lung three warp." function cures mainly: loose wind heat, lung qi dispersing, determines convulsion.Control affection due to external wind and heat, cough hoarseness, measles is sent out not smooth thoroughly, rubella pruritus, pediatric epilepsy scared, conjunctival congestion, cataracta, furuncle swelling toxin, tetanus.
Pheretima: nature and flavor: salty in the mouth; Cold in nature.Gui Jing: return liver; Spleen; Urinary bladder channel.Function cures mainly: clear gesture relieving convulsion; Suppressing the hyperactive liver to relieve the wind syndrome; Dredge the meridian passage; To relieving asthma diuresis.Main calentura heating is mad dry; Infantile convulsion is twitched; Headache due to hyperactivity of liver-YANG; Apoplectic hemiplegia; Rheumatic arthralgia; Dyspnea and cough due to lung-heat; Urinary obstruction.
Radix Salviae Miltiorrhizae: nature and flavor: bitter, is slightly cold.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Radix Dipsaci: meridian distribution of property and flavor: bitter, pungent, tepor.Return liver, kidney channel.Function cures mainly: this kind of root is used as medicine, and has promoting the circulation of blood detumescence, granulation promoting pain relieving, reunion of fractured tendons and bones, invigorating the liver and kidney, strong waist knee joint, antiabortive effect.Bone and muscle strengthening, sharp joint, only metrorrhagia.For soreness of waist and knee joint, rheumatic arthritis, fracture, traumatic injury, threatened abortion, metrorrhagia, leukorrheal diseases, seminal emission, frequent micturition.Bencao Tujing: Radix Dipsaci, modern Shaanxi, korneforos, Xing Yuanfu, relax, more, Jinzhou also has it.Raw Seedling after March, dry four ribs, like Boehmeria; Leaf also class it, relatively give birth between two; Blossom in April, red and white, like Herba Leonuri flower; Root as Radix Cirsii Japonici, helvolus.July, August adopt.Careful by " Fan Wangfang " cloud, namely Radix Dipsaci is horse Ji, similar to little Artichoke leaf, but be greater than Herba Cirsii that, leaf is little thick like other father-in-law's dish, both sides spinosity thorn people, its flower purple, state survivor's phase class is got over the present, and the goods in city is seen, also there are several, can distinguish that its rent is good less, doctor people, with it, but is true with disconnected, Beijing opera wrinkle person successively.
Soybean isoflavone: containing mineral such as abundant natural complex and ferrum, zinc, calcium, the combination that this product adopts current international most advanced CO2 supercritical low-temperature extraction technology to skim the cream off milk.Modern study finds, middle aged and aged women decrease in estrogen is very fast, the decline of estrogen level and fluctuation, easily cause autonomic nervous system dysfunction, and as occurred, agitation, insomnia, hypomnesis, hyposexuality, sexual life are inharmonious, painstaking effort functional disorder, climacteric syndrome.Complementing estrogen can guarantee bone mass, bone density, with prevention of osteoporosis.Often take this product and greatly will alleviate the above-mentioned various ill symptom of middle and aged women, improve their healthy living quality, another women remains youth appearance.
Flos Rosae Rugosae: resolving depression of regulating the flow of vital energy, and blood dissipating blood stasis.Treating the liver peratodynia, new lingering pathogenic wind numbness, spitting of blood of spitting blood, menoxenia, leucorrhea with red and white discharge, dysentery, acute mastitis, toxic swelling.1. Yao can become " food book on Chinese herbal medicine ": " gas of the evil that exorcises evil spirits, the fragrance of food is sweet and refreshing, makes us refreshing refreshing for main sharp lung spleen, the liver benefiting gallbladder." 2. " property of medicine is examined ": " promoting the circulation of blood removing mass, damage stasis of blood pain, infusing drugs in wine is drunk." 3. " detailed outline is picked up any lost article from the road ": " and blood, promoting the circulation of blood, regulates the flow of vital energy.Control migratory arthralgia.The strongly fragrant gas of " 4. " book on Chinese herbal medicine is new again ": " soothing liver-QI gallbladder, spleen invigorating pathogenic fire reducing.Control cold type of pain in abdomen, gastral cavilty is long-pending cold, and holding concurrently can removing blood stasis." 5. " occupying diet spectrum with breath ": " invigorates blood circulation in adjusting, and Shu Yujie, wards off dirty, regulating liver-QI.Wine brewing can disappear nodules of the breast." 6. " modern Practical Chinese medicinal ": " for married woman's menorrhagia, leucorrhea with red and white discharge and general enteritis dysentery etc." 7. " Shandong Chinese medicine ": " is controlled and is looked up with eyes wide open peratodynia, nausea and vomiting, dyspepsia, has loose bowels, and dispute gruel is broken, spits blood, fasting dysentery."
Semen Cassiae: bitter in the mouth, sweet, salty, cold nature, enters liver, kidney, large intestine channel; Loosening bowel to relieve constipation, blood fat reducing improving eyesight, treatment constipation and hyperlipidemia, hypertension.Liver heat removing and eyesight improving, diuretic relieving constipation, has laxative action, reducing blood pressure and blood fat.
Flos Carthami: nature and flavor: pungent, temperature.1. " Kaibao Bencao ": pungent, temperature, nontoxic.2. Materia Medica of Decoction: pungent and sweet temperature is bitter.Gui Jing: enter the heart, Liver Channel.1. " Thunder God concocts property of medicine solution ": enter the heart, liver two warp.2. " book on Chinese herbal medicine is through separating ": enter liver channel of foot-Jueyin, lung meridian.3. " book on Chinese herbal medicine is new again ": enter liver, kidney two warp.Function cures mainly: promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.Control amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.
Fructus Akebiae: nature and flavor: hide micro-hardship, property is put down.Return liver, stomach, urinary bladder channel.Gui Jing: liver; Stomach warp.Function cures mainly: dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor.
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
A, by Herba Violae japonicae 5 parts, Herba Lysimachiae 5 parts, Rhizoma Coptidis 5 parts, fresh Radix Boehmeriae 5 parts, 5 parts, Pericarpium Citri Reticulatae Viride, Fructus Forsythiae 5 parts, Flos Lonicerae 5 parts, Herba Taraxaci 5 parts, Fructus Arctii 5 parts, Radix Platycodonis 5 parts, Radix Angelicae Sinensis 5 parts, Radix Notoginseng 5 parts, the Radix Angelicae Dahuricae 5 parts, the Radix Astragali 5 parts, Radix Et Rhizoma Rhei 5 parts, Rhizoma Chuanxiong 5 parts, Concha Arcae 5 parts, Fructus Lycii 5 parts, 10 parts, Radix Glycyrrhizae, Radix Polygoni Multiflori Preparata 10 parts, 10 parts, Fructus Jujubae, 10 parts, Poria, Myrrha 10 parts, Rhizoma Curcumae 10 parts, Radix Trichosanthis 10 parts, Caulis Spatholobi 10 parts, Fructus Trichosanthis 10 parts, Periostracum Cicadae 10 parts, Pheretima 10 parts, Radix Salviae Miltiorrhizae 5 parts, Radix Dipsaci 10 parts, soybean isoflavone 10 parts, Flos Rosae Rugosae 10 parts, Semen Cassiae 10 parts, 10 parts, Flos Carthami, Fructus Akebiae 10 parts of crude drug mixing, chopping, cross 120 mesh sieves, obtain thin medicated powder for subsequent use.
B. above-mentioned unsifted coarse powder is added in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-180 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating is concentrated, stand for standby use.
C. the medicinal residues that ethanol extraction is crossed are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, then uses aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.14, heating is concentrated, stand for standby use.
D. merged by above-mentioned two kinds of extracting solution, decompression recycling ethanol becomes extractum, obtains thin medicated powder merge and add Mel and be twisted into pill with a step.
Embodiment 2
A, by Herba Violae japonicae 5 parts, Herba Lysimachiae 5 parts, Rhizoma Coptidis 5 parts, fresh Radix Boehmeriae 5 parts, 5 parts, Pericarpium Citri Reticulatae Viride, Fructus Forsythiae 5 parts, Flos Lonicerae 5 parts, Herba Taraxaci 5 parts, Fructus Arctii 5 parts, Radix Platycodonis 5 parts, Radix Angelicae Sinensis 5 parts, Radix Notoginseng 5 parts, the Radix Angelicae Dahuricae 5 parts, the Radix Astragali 5 parts, Radix Et Rhizoma Rhei 5 parts, Rhizoma Chuanxiong 5 parts, Concha Arcae 5 parts, Fructus Lycii 5 parts, 10 parts, Radix Glycyrrhizae, Radix Polygoni Multiflori Preparata 10 parts, 10 parts, Fructus Jujubae, 10 parts, Poria, Myrrha 10 parts, Rhizoma Curcumae 10 parts, Radix Trichosanthis 10 parts, Caulis Spatholobi 10 parts, Fructus Trichosanthis 10 parts, Periostracum Cicadae 10 parts, Pheretima 10 parts, Radix Salviae Miltiorrhizae 5 parts, Radix Dipsaci 10 parts, soybean isoflavone 10 parts, Flos Rosae Rugosae 10 parts, Semen Cassiae 10 parts, 10 parts, Flos Carthami, Fructus Akebiae 10 parts of crude drug mixing, chopping, cross 120 mesh sieves, obtain thin medicated powder for subsequent use.
B, above-mentioned unsifted coarse powder added in the ethanol of 5-10 times amount and soaks 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-180 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 1;
10 times of water gagings put into by c, the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 2;
D, above-mentioned two kinds of extracting solution to be merged, decompression recycling ethanol spraying dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
Embodiment 3
A, get Herba Violae japonicae 5 parts, Herba Lysimachiae 5 parts, Rhizoma Coptidis 5 parts, fresh Radix Boehmeriae 5 parts, 5 parts, Pericarpium Citri Reticulatae Viride, Fructus Forsythiae 5 parts, Flos Lonicerae 5 parts, Herba Taraxaci 5 parts, Fructus Arctii 5 parts, Radix Platycodonis 5 parts, Radix Angelicae Sinensis 5 parts, Radix Notoginseng 5 parts, the Radix Angelicae Dahuricae 5 parts, the Radix Astragali 5 parts, Radix Et Rhizoma Rhei 5 parts, Rhizoma Chuanxiong 5 parts, Concha Arcae 5 parts, Fructus Lycii 5 parts, 10 parts, Radix Glycyrrhizae, Radix Polygoni Multiflori Preparata 10 parts, 10 parts, Fructus Jujubae, 10 parts, Poria, Myrrha 10 parts, Rhizoma Curcumae 10 parts, Radix Trichosanthis 10 parts, Caulis Spatholobi 10 parts, Fructus Trichosanthis 10 parts, Periostracum Cicadae 10 parts, Pheretima 10 parts, Radix Salviae Miltiorrhizae 5 parts, Radix Dipsaci 10 parts, soybean isoflavone 10 parts, Flos Rosae Rugosae 10 parts, Semen Cassiae 10 parts, 10 parts, Flos Carthami, Fructus Akebiae 10 parts of crude drug are put into ethanol and are soaked, heat is extracted 2 times, become paste, for component 1,
B, medicinal residues water extraction 2 times, thickening filtration is paste, is component 2;
C, above-mentioned two kinds of component pastes are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, then vacuum canning sealing and get final product, and directly drinks during use.
The animal toxicity test of pharmaceutical composition of the present invention
1, apply mice to carry out acute toxicity testing and show: Mouse oral gavage Traditional Chinese medicine preparation capsule of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule of the present invention is 488.8g crude drug/kg/d (LD50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.
2, SD rat is selected, give the Chinese medicine preparation pill of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
3, SD rat is selected, give the Traditional Chinese medicine preparation capsule agent of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
Pharmacological experiment illustrates:
Chinese medicine composition of the present invention was in 2010 to 2015 the routine patients of clinical observation lump in breast 203, and clinical report is as follows: select case to be diagnosed as the patient of benign breast lump to go to the hospital by prefecture-level front three; Age is minimum is 18 years old, is 70 years old to the maximum.
Be divided into Types Below by check result:
A. mammary gland fibroadenoma 68 example, wherein simple adenoma of breast 2 example, merges cyclomastopathy 10 example.
B. cyclomastopathy 88 example.
C. mastitis 47 example, is women breast-feeding their children, side or bilateral breast redness, pain, lump tenderness, heating.
By above-mentioned a, b, c tri-kinds of patients respectively with medicine prepared by the embodiment of the present invention 1, observe each group for the treatment of situation.
2, curative effect determinate standard
(1) fully recover: mastalgia and lump disappear, and drug withdrawal has no recurrence in three months.
(2) effective: lump in breast reduces more than 1/2nd, pain obviously alleviates or substantially disappears.
(3) effective: lump in breast reduces less than 1/2nd, pain relief.
(4) invalid: lump in breast does not change, pain does not slow down or increases the weight of, or after alleviating again recurrence with original.
3, therapeutic outcome.
Group N Recovery from illness Effective Effectively Invalid
Mammary gland fibroadenoma 68 41 26 1 0
Cyclomastopathy 88 43 35 9 1
Mastitis 47 37 11 7 1
Clinical effectiveness also show Chinese medicine preparation of the present invention has significant curative effect to the lump in breast that mammary gland fibroadenoma, cyclomastopathy, mastitis produce, and instant effect, side effect is little, and expense is low.
The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.

Claims (10)

1. treat a Chinese medicine preparation for lump in breast and cystic hyperplasia, it is characterized in that: be made up of each component of following parts by weight:
Herba Violae japonicae 1-30 part, Herba Lysimachiae 1-30 part, Rhizoma Coptidis 1-30 part, fresh Radix Boehmeriae 1-30 part, Pericarpium Citri Reticulatae Viride 1-30 part, Fructus Forsythiae 1-30 part, Flos Lonicerae 1-30 part, Herba Taraxaci 1-30 part, Fructus Arctii 1-30 part, Radix Platycodonis 1-30 part, Radix Angelicae Sinensis 1-30 part, Radix Notoginseng 1-30 part, Radix Angelicae Dahuricae 1-30 part, Radix Astragali 1-30 part, Radix Et Rhizoma Rhei 1-30 part, Rhizoma Chuanxiong 1-30 part, Concha Arcae 1-30 part, Fructus Lycii 1-30 part, Radix Glycyrrhizae 1-30 part, Radix Polygoni Multiflori Preparata 1-30 part, Fructus Jujubae 1-30 part, Poria 1-30 part, Myrrha 1-30 part, Rhizoma Curcumae 1-30 part, Radix Trichosanthis 1-30 part, Caulis Spatholobi 1-30 part, Fructus Trichosanthis 1-30 part, Periostracum Cicadae 1-30 part, Pheretima 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Radix Dipsaci 1-30 part, soybean isoflavone 1-30 part, Flos Rosae Rugosae 1-30 part, Semen Cassiae 1-30 part, Flos Carthami 1-30 part, Fructus Akebiae 1-30 part.
2. a kind of Chinese medicine preparation for the treatment of lump in breast and cystic hyperplasia according to claim 1, is characterized in that: be made up of each component of following parts by weight:
Herba Violae japonicae 10-30 part, Herba Lysimachiae 5-30 part, Rhizoma Coptidis 5-30 part, fresh Radix Boehmeriae 5-30 part, Pericarpium Citri Reticulatae Viride 5-30 part, Fructus Forsythiae 5-30 part, Flos Lonicerae 5-30 part, Herba Taraxaci 5-30 part, Fructus Arctii 5-30 part, Radix Platycodonis 5-30 part, Radix Angelicae Sinensis 5-30 part, Radix Notoginseng 5-30 part, Radix Angelicae Dahuricae 5-30 part, Radix Astragali 5-30 part, Radix Et Rhizoma Rhei 5-30 part, Rhizoma Chuanxiong 5-30 part, Concha Arcae 5-30 part, Fructus Lycii 5-30 part, Radix Glycyrrhizae 1-30 part, Radix Polygoni Multiflori Preparata 1-30 part, Fructus Jujubae 1-30 part, Poria 1-30 part, Myrrha 1-30 part, Rhizoma Curcumae 1-30 part, Radix Trichosanthis 1-30 part, Caulis Spatholobi 1-30 part, Fructus Trichosanthis 1-30 part, Periostracum Cicadae 1-30 part, Pheretima 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Radix Dipsaci 1-30 part, soybean isoflavone 1-30 part, Flos Rosae Rugosae 1-30 part, Semen Cassiae 1-30 part, Flos Carthami 1-30 part, Fructus Akebiae 1-30 part.
3. according to a kind of Chinese medicine preparation for the treatment of lump in breast and cystic hyperplasia described in claim 1 to 2, it is characterized in that: be made up of each component of following parts by weight:
Herba Violae japonicae 10-30 part, Herba Lysimachiae 5-30 part, Rhizoma Coptidis 5-30 part, fresh Radix Boehmeriae 5-30 part, Pericarpium Citri Reticulatae Viride 5-30 part, Fructus Forsythiae 5-30 part, Flos Lonicerae 5-30 part, Herba Taraxaci 5-30 part, Fructus Arctii 5-30 part, Radix Platycodonis 5-30 part, Radix Angelicae Sinensis 5-30 part, Radix Notoginseng 5-30 part, Radix Angelicae Dahuricae 5-30 part, Radix Astragali 5-30 part, Radix Et Rhizoma Rhei 5-30 part, Rhizoma Chuanxiong 5-30 part, Concha Arcae 5-30 part, Fructus Lycii 5-30 part, Radix Glycyrrhizae 10-30 part, Radix Polygoni Multiflori Preparata 10-30 part, Fructus Jujubae 10-30 part, Poria 10-30 part, Myrrha 10-30 part, Rhizoma Curcumae 10-30 part, Radix Trichosanthis 10-30 part, Caulis Spatholobi 10-30 part, Fructus Trichosanthis 10-30 part, Periostracum Cicadae 10-30 part, Pheretima 10-30 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Dipsaci 10-30 part, soybean isoflavone 10-30 part, Flos Rosae Rugosae 10-30 part, Semen Cassiae 10-30 part, Flos Carthami 10-30 part, Fructus Akebiae 10-30 part.
4. a kind of Chinese medicine preparation for the treatment of lump in breast and cystic hyperplasia according to claims 1 to 3, is characterized in that: the dosage form of described Chinese medicine preparation is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.
5. a kind of preparation method for the treatment of the Chinese medicine preparation of lump in breast and cystic hyperplasia according to Claims 1-4, is characterized in that: the dosage form of described endo-medicine is pill, comprising of its preparation process:
A. described crude drug is mixed, chopping, cross 120 mesh sieves, obtain thin medicated powder for subsequent use;
B. unsifted coarse powder is soaked in ethanol and extract 2 times;
C. the medicinal residues after above-mentioned steps extraction are got again, the heating and refluxing extraction that adds water 2 times;
D. merged by above-mentioned two kinds of extracting solution, decompression recycling ethanol becomes extractum, obtains thin medicated powder merge and add Mel and be twisted into pill with a step.
6. a kind of preparation method for the treatment of the Chinese medicine preparation of lump in breast and cystic hyperplasia according to claim 5, it is characterized in that: in described step b, get raw material and add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-180 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating is concentrated, stand for standby use.
7. a kind of preparation method for the treatment of the Chinese medicine preparation of lump in breast and cystic hyperplasia according to claim 5, it is characterized in that: in described step c, 10 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, 100-120 order filters, use aperture at 1000um again, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.14, heating is concentrated, stand for standby use.
8. a preparation method for the treatment lump in breast as described in claim 1 to 8 and the Chinese medicine preparation of cystic hyperplasia, is characterized in that, described preparation formulation is capsule, comprising of its preparation method:
A. described raw material is put into pulverizer grinding and sieving;
B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;
C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 1 time;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
9. a preparation method for the treatment lump in breast as described in claim 1 to 9 and the Chinese medicine preparation of cystic hyperplasia, is characterized in that, the oral solutions that described preparation formulation is, comprising of its preparation method:
A, get raw material and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;
B, medicinal residues water extraction 2 times, thickening filtration is paste, is component 2;
C, above-mentioned two kinds of pastes are condensed into pasty state, sterilizing, add dextrin, then vacuum freezing sealing.
10. a kind of preparation method for the treatment of the Chinese medicine preparation of lump in breast and cystic hyperplasia according to claim 9, it is characterized in that: in described step c, above-mentioned two kinds of component pastes are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, add dextrin, then vacuum canning sealing and get final product, directly drink during use.
CN201510976805.4A 2015-12-23 2015-12-23 Traditional Chinese medicine preparation for treating breast lumps and cystic hyperplasia and preparation method thereof Pending CN105381414A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112791147A (en) * 2021-02-03 2021-05-14 张文博 Traditional Chinese medicine for treating nodules of breast and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
李月玲: ""消核饮内服配合离子透入治疗乳腺增生260例"", 《四川中医》 *
汤礼共: ""早期乳痈分期论治的体会"", 《光明中医》 *
陈文莉: ""乳痈的辨证治疗及护理"", 《河北中医》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112791147A (en) * 2021-02-03 2021-05-14 张文博 Traditional Chinese medicine for treating nodules of breast and preparation method thereof

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