CN107320631B - Anti-fatigue traditional Chinese medicine composition and preparation method thereof - Google Patents
Anti-fatigue traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an anti-fatigue traditional Chinese medicine composition, which is prepared by compounding more than 20 traditional Chinese medicines of astragalus, codonopsis pilosula, ginseng and the like according to a reasonable proportion, so that the drug effects of the components generate a synergistic effect, the body immunity is enhanced, and the physical fatigue of people is relieved. The invention also provides a preparation method of the traditional Chinese medicine composition.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to an anti-fatigue traditional Chinese medicine composition and a preparation method thereof.
Background
With the advent of informatization and globalization, fatigue syndrome has become a ubiquitous problem for workers in the world. According to the investigation of the world health organization, more than 35% of people in the world are in fatigue state, and the fatigue state of male population is higher up to 60-70%. Statistics show that: about 2 hundred million people in China are in a sub-healthy fatigue state, and the urban morbidity of the fatigue syndrome in China is 10-20%.
Fatigue is a protective response that prevents the body from experiencing life-threatening excessive failure. The physiological and pathological reasons for fatigue are various, and from the traditional Chinese medical and health-preserving viewpoints, fatigue can be caused by kidney deficiency, qi deficiency, overwork, unsmooth qi and blood, absentmindedness and the like, and the fatigue can cause the phenomena of physical weakness, hypoimmunity, cerebral reaction retardation, premature senility and the like. Although fatigue does not cause death directly and rapidly like cancer and heart disease, the fatigue serving as an invisible killer endangering the health of modern people seriously affects the work and life of people and greatly increases the number of sub-health people. When a human body is in a fatigue state for a long time, premature senility and fatigue syndrome can be generated, and death can be accelerated even if the human body is in a fatigue state.
How to enhance the immunity of people in the modern life environment with more and more rhythm and pressure, relieve the physical fatigue of people, keep away from the sub-health state, protect the normal body functions of people and improve the life quality is the problem to be solved by medical researchers. People hope to take a food or health care product which is convenient, has no side effect and is effective for a long time to relieve various sub-health states, Chinese medicine is profound, medicinal materials are natural, and the food or health care product has unique advantages in the aspects of health preservation and human body fatigue resistance.
Chinese patent publication No. CN 105770177A discloses an anti-fatigue Chinese medicinal preparation, which comprises 20-40% of apricot leaf extract, 20-40% of American ginseng extract, 15-30% of medlar extract, 15-30% of astragalus extract, 2-10% of ferrous lactate, and the balance of auxiliary materials. The formula has the effect of improving the anti-fatigue effect and has no obvious side effect.
Chinese patent document with publication number CN 104623061A discloses an anti-fatigue traditional Chinese medicine, which comprises the following raw materials: 5-30 parts of codonopsis pilosula, 5-20 parts of poria cocos, 5-12 parts of bighead atractylodes rhizome, 5-20 parts of white peony root, 3-9 parts of ligusticum wallichii, 5-10 parts of honey-fried licorice root, 1.5-12 parts of polygala tenuifolia, 5-15 parts of angelica sinensis, 5-20 parts of radix rehmanniae, 7-20 parts of achyranthes bidentata, 5-9 parts of adenophora stricta and 5-20 parts of prepared rehmannia. Can be made into decoction, granule, tablet, pill, and paste, and has effects of increasing blood and oxygen supply for heart and brain, and relieving fatigue.
Chinese patent publication No. CN 105497495a discloses a Chinese medicinal composition with anti-fatigue effect, and its preparation method and use. The traditional Chinese medicine composition comprises the following raw medicines: 3-9 parts of ginseng, 3-9 parts of schisandra chinensis, 6-10 parts of radix ophiopogonis, 6-10 parts of wolfberry fruit and 6-12 parts of salvia miltiorrhiza. The Chinese medicinal composition can obviously enhance swimming endurance, has anti-fatigue effect, and can be used as a potential anti-fatigue medicament.
There is still a need in the art to develop new anti-fatigue Chinese medicinal compositions to provide better anti-fatigue and health-care effects.
Disclosure of Invention
The invention aims to provide an anti-fatigue traditional Chinese medicine composition which has the effects of enhancing body immunity and relieving physical fatigue of people; in addition, the traditional Chinese medicine composition can also improve the mental fatigue symptoms such as lassitude, distraction, insomnia, amnesia and the like caused by excessive mental labor, physical labor or long-term mental tension. The invention also provides a preparation method of the anti-fatigue traditional Chinese medicine composition.
In order to achieve the above purpose, one aspect of the present invention provides an anti-fatigue traditional Chinese medicine composition, which comprises the following components in parts by weight:
18-25 parts of astragalus membranaceus, 12-18 parts of codonopsis pilosula, 14-18 parts of ginseng, 6-12 parts of peach kernel, 5-10 parts of safflower, 18-25 parts of salvia miltiorrhiza, 10-15 parts of ligusticum wallichii, 12-18 parts of angelica sinensis, 24-30 parts of lumbricus, 24-30 parts of zaocys dhumnade, 26-35 parts of radix morindae officinalis, 26-32 parts of eucommia ulmoides, 26-32 parts of epimedium, 26-35 parts of cistanche, 6-12 parts of cinnamon, 24-32 parts of prepared rehmannia rhizome, 16-22 parts of antler slices, 12-18 parts of mulberry, 12-18 parts of medlar, 24-30 parts of rhizoma polygonati, 12-18 parts of glossy privet fruit, 18-24 parts of eclipta alba and 12-20 parts of raspberry.
Further, the traditional Chinese medicine composition comprises the following components in parts by weight:
18-23 parts of astragalus membranaceus, 13-16 parts of codonopsis pilosula, 15-18 parts of ginseng, 6-10 parts of peach kernel, 5-8 parts of safflower, 18-22 parts of salvia miltiorrhiza, 10-14 parts of ligusticum wallichii, 12-16 parts of angelica sinensis, 26-30 parts of lumbricus, 26-30 parts of zaocys dhumnade, 28-34 parts of radix morindae officinalis, 26-30 parts of eucommia ulmoides, 28-32 parts of epimedium, 28-33 parts of cistanche, 6-11 parts of cinnamon, 26-31 parts of prepared rehmannia rhizome, 17-21 parts of antler slices, 13-18 parts of mulberry, 12-16 parts of medlar, 26-30 parts of rhizoma polygonati, 12-16 parts of glossy privet fruit, 18-22 parts of eclipta alba and 12-18 parts of raspberry.
Further, the traditional Chinese medicine composition comprises the following components in parts by weight:
20-22 parts of astragalus membranaceus, 14-16 parts of codonopsis pilosula, 15-17 parts of ginseng, 8-10 parts of peach kernels, 5-6 parts of safflower, 18-20 parts of salvia miltiorrhiza, 10-13 parts of ligusticum wallichii, 12-15 parts of angelica sinensis, 28-30 parts of lumbricus, 28-30 parts of zaocys dhumnade, 30-34 parts of morinda officinalis, 28-30 parts of eucommia ulmoides, 30-32 parts of epimedium, 30-32 parts of cistanche, 8-10 parts of cinnamon, 28-30 parts of prepared rehmannia rhizome, 18-20 parts of antler slices, 14-16 parts of mulberries, 12-15 parts of lycium barbarum, 28-30 parts of polygonatum kingianum, 12-15 parts of glossy privet fruits, 18-20 parts of eclipta alba and 15-18 parts of.
In one embodiment, the traditional Chinese medicine composition comprises the following components in parts by weight:
20 parts of astragalus membranaceus, 15 parts of codonopsis pilosula, 15 parts of ginseng, 10 parts of peach kernel, 5 parts of safflower, 20 parts of salvia miltiorrhiza, 10 parts of ligusticum wallichii, 15 parts of angelica sinensis, 30 parts of lumbricus, 30 parts of zaocys dhumnade, 30 parts of radix morindae officinalis, 30 parts of eucommia ulmoides, 30 parts of epimedium, 30 parts of cistanche, 10 parts of cinnamon, 30 parts of prepared rehmannia rhizome, 20 parts of antler pieces, 15 parts of mulberry, 15 parts of medlar, 30 parts of rhizoma polygonati, 15 parts of glossy privet fruit, 20 parts of eclipta alba and 15 parts of raspberry.
In another embodiment, the traditional Chinese medicine composition comprises the following components in parts by weight:
22 parts of astragalus membranaceus, 16 parts of codonopsis pilosula, 17 parts of ginseng, 9 parts of peach kernel, 6 parts of safflower, 18 parts of salvia miltiorrhiza, 12 parts of ligusticum wallichii, 12 parts of angelica sinensis, 28 parts of lumbricus, 28 parts of zaocys dhumnade, 33 parts of radix morindae officinalis, 28 parts of eucommia ulmoides, 32 parts of epimedium, 32 parts of cistanche, 8 parts of cinnamon, 28 parts of prepared rehmannia rhizome, 20 parts of antler slice, 16 parts of mulberry, 12 parts of medlar, 28 parts of rhizoma polygonati, 12 parts of glossy privet fruit, 18 parts of eclipta alba and 18 parts of raspberry.
The effects of each component are as follows:
astragalus root: also named as astragalus root. Perennial herbs. Sweet and warm. It enters lung, spleen, liver and kidney meridians. It has effects in enhancing immunity, protecting liver, promoting urination, resisting aging, resisting stress, lowering blood pressure, and inhibiting bacteria. Can eliminate albuminuria caused by experimental nephritis, enhance myocardial contraction force, and regulate blood sugar content. Radix astragali can not only dilate coronary artery, improve myocardial blood supply, and enhance immunity, but also delay cell aging process.
Codonopsis pilosula: a perennial herb belonging to the genus Codonopsis of the family Campanulaceae. Sweet root, neutral root. Tonify middle-jiao and Qi, harmonize stomach and promote fluid production, dispel phlegm and relieve cough. Has the effects of invigorating spleen and replenishing qi, and invigorating spleen and lung. Radix Codonopsis has effects of enhancing immunity, dilating blood vessel, lowering blood pressure, improving microcirculation, and improving hemopoiesis function. In addition, the composition has an effect of improving leucocyte reduction caused by chemotherapy and radiotherapy.
Ginseng: is a perennial herb, which is called the king of Huangshen, Dijing, Shencao and Baicao. The record of Shen nong Ben Cao Jing: ginseng, radix Ginseng, sweet in taste and slightly cold in nature, has the effects of nourishing five internal organs, calming mind, stopping palpitation, eliminating pathogenic factors, improving eyesight, and improving intelligence. It can be taken for a long time, and has effects of reducing weight and prolonging life. One for each person and one for each ghost. A raw valley ". The succulent root of ginseng is a well-known tonic, is suitable for regulating blood pressure, recovering heart function, neurasthenia and asthenia, and also has expectorant, stomach invigorating, diuretic and exciting effects.
Peach kernel: is dried mature seed of Prunus persica or Prunus davidiana of Rosaceae. Bitter, sweet and neutral. It enters heart, liver and large intestine meridians. Has the effects of promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, and relieving cough and asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal carbuncle, traumatic injury, intestinal dryness, constipation, cough, and asthma.
Safflower: alias: carthamus tinctorius flower, Compositae, and Carthamus plant. Pungent and warm in nature. Enter heart and liver meridians. Promoting blood circulation, dredging channels, removing blood stasis, and relieving pain, and can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, thoracic obstruction, cardialgia, blood stasis, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, and pyocutaneous disease with swelling and pain. Has effects of promoting blood circulation, removing blood stasis, eliminating dampness, and relieving swelling.
Red sage root: is dried root and rhizome of Salvia miltiorrhiza Bunge of Labiatae. Bitter and slightly cold in taste. It enters heart and liver meridians. Has the effects of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.
Ligusticum wallichii: pungent and warm in flavor. Entering liver and gallbladder meridians. The rhizome of Sichuan lovage is pungent, warm, fragrant and dry, and can be scattered and ascended to the vertex; it enters the blood system and goes down to reach the blood sea. It is suitable for various diseases caused by blood stasis, and can be used for treating headache, and rheumatalgia. Xiren is that Chuan Xiong is a qi-flowing medicine in blood, but it has the functions of dispersing acrid, relieving depression, dredging and relieving pain. It is indicated for wind-cold headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, postpartum pain due to blood stasis, carbuncle, cellulitis, sore and ulcer.
Chinese angelica: the herbs are also called as Gui, Qin and xi Dang Gui, and are perennial herbs, and the root of the herb can be used as a medicine, which is one of the most commonly used Chinese herbs. Sweet, pungent and warm in nature. It enters liver, heart and spleen meridians. Has effects in nourishing blood, regulating menstruation, relieving pain, moistening dryness, smoothing intestine, resisting cancer, resisting aging, and enhancing immunity.
Earthworm: earthworm is one of the important Chinese medicinal materials in China. Earthworms exist in 67 animal medicines collected in the earliest monograph of traditional Chinese medicine science, Shennong's herbal Jing. Listed as the inferior product in Shen nong Ben Cao Jing, it has the effects of clearing heat and calming endogenous wind, clearing and activating the channels and collaterals, clearing away the lung-heat and relieving asthma, and clearing heat and promoting urination. After being stir-baked, the Chinese medicinal composition is used for treating high fever, coma, fright epilepsy and convulsion, arthralgia, cough and asthma due to lung heat, oliguria and edema, hypertension and the like. Contains multiple amino acids.
Black-tail snake: zaocys, commonly known as Zaocys and Zaocys, is a large sized snake of Zaocys of Colubridae. The black-tail snake in the traditional Chinese medicine is a dry product after the seed treatment. Sweet and neutral. It enters liver meridian. Dispel wind, unblock collaterals, stop convulsions. Can be used for treating rheumatism, numbness, spasm, facial distortion, hemiplegia, convulsion, tetanus, leprosy, scabies, and lymphoid tuberculosis.
Radix Morindae officinalis: is the root of Morinda officinalis of Rubiaceae family, commonly known as JICHANGFENG, is one of four southern medicines in China, and contains anthraquinone and flavonoid compounds. Pungent and sweet with warm nature. Enter liver and kidney meridians. Has the effects of strengthening blood and qi, strengthening muscles and bones, expelling wind-damp, nourishing and strengthening yang, and is a traditional Chinese medicine for tonifying kidney and strengthening yang and strengthening muscles and bones.
Eucommia ulmoides: also called as Bakelia, the Chinese medicinal material is dry bark of eucommia ulmoides Oliver belonging to family Eucommiaceae. It is sweet in taste and warm in nature. It enters liver and kidney meridians. Has effects in tonifying liver and kidney, strengthening muscle and bone, regulating Chong and ren meridians, and preventing miscarriage. Can be used for treating lumbago, leg pain, soreness, weakness, and asthenia due to kidney yang deficiency, and symptoms such as hypochondriac instability, and scrotum pruritus due to liver qi deficiency. Modern researches show that eucommia bark has the pharmacological effects of clearing away in-vivo garbage, strengthening the metabolism of human cell substances, preventing the aging of musculoskeletal tissues, balancing the blood pressure of human bodies, decomposing cholesterol in the bodies, reducing in-vivo fat, restoring the elasticity of blood vessels, inducing diuresis, clearing heat, resisting bacteria in a broad spectrum, exciting central nerves and improving leucocytes.
Herba epimedii: epimedium herb of berberidaceae belongs to perennial herb, and whole plant of Epimedium herb is used as medicine. It can be used for treating sexual impotence, premature ejaculation, soreness of waist, skelalgia, numbness of limbs, hemiplegia, neurasthenia, amnesia, tinnitus, and blurred vision. Modern researches show that epimedium contains icariine, volatile oil, ceryl alcohol, phytosterol, tannin, vitamin E and other components, can excite sexual function and has the effect of promoting semen secretion of animals. It also has blood pressure lowering (peripheral vasodilation inducing), blood glucose lowering, diuretic, antitussive, expectorant, and vitamin E-like effects. Herba Epimedii can increase cardiovascular and cerebrovascular blood flow, promote hemopoiesis, immunity and bone metabolism, and has antiaging and antitumor effects.
Cistanche deserticola: the alias of Jiangxu, Cistanchis herba is parasitic plant parasitic on root of desert tree Haloxylon ammodendron, and has reputation of desert ginseng and high medicinal value. Sweet, salty and warm in nature; it enters kidney and large intestine meridians. Has the effects of invigorating kidney yang, replenishing essence and blood, and moistening intestinal tract. Mainly treats kidney-yang deficiency; impotence due to deficiency of essence and blood; spermatorrhea; white turbidity; frequent micturition and dribbling; lumbago and weak feet; tinnitus and blurred vision; menstrual period of menstruation; infertility due to cold uterus; constipation due to intestinal dryness.
Cinnamon: also called cortex Cinnamomi, Concha Ostreae, and Chinese cortex Cinnamomi Japonici, is the dried bark of Cinnamomum Cassia Presl of Lauraceae. Fragrant, and can be used as perfume. Cinnamon contains rich nutrient components, has a strong health-care effect, has sweet and pungent smell, can tonify vitality and yang, warm spleen and stomach, remove cold accumulation and promote blood circulation. Can be used for treating decline of vital gate fire, cold limbs, weak pulse, yang exhaustion, asthenia, abdominal pain, diarrhea, cold hernia, cold pain of waist and knee, amenorrhea, cellulitis in yin, multiple abscess, and floating yang, upper heat and lower cold.
Prepared rhizome of rehmannia: is prepared from radix rehmanniae Preparata or radix rehmanniae Preparata of Scrophulariaceae. Sweet and warm. It enters liver and kidney meridians. The prepared rehmannia root is a superior traditional Chinese medicine, has the effects of enriching blood and nourishing yin, can be used for treating blood deficiency and chlorosis, dizziness, palpitation and insomnia, irregular menstruation, metrorrhagia and metrostaxis and the like, can also be used for treating tidal fever and bone steaming, night sweat, spermatorrhea, diabetes and the like caused by kidney yin deficiency, and is one of the main components of a deficiency syndrome type over-the-counter medicament, namely a six-ingredient rehmannia pill.
Antler pieces: the cornu Cervi tablet has effects of invigorating kidney yang, replenishing essence and blood, strengthening tendons and bones, promoting blood circulation and detumescence, and can be used for treating kidney essence deficiency, waist and spine psychroalgia, sexual impotence, nocturnal emission, metrorrhagia, leucorrhea, pollakisuria, polyuria, dorsal furuncle, pyocutaneous disease, mammary abscess, swelling and pain, traumatic injury, blood stasis and swelling, and bone and muscle pain. Contains colloid 25%, calcium phosphate 50-60%, calcium carbonate and nitride. And also contains various amino acids.
Mulberry: mature dry fruit of mulberry. The medicinal value and the use of mulberry are elaborated in various medical classics such as Bencao gang mu, etc., and the mulberry has the efficacies of tonifying liver and kidney, promoting the production of body fluid and lubricating intestines, blackening hair and improving eyesight, quenching thirst and detoxifying, beautifying and the like after entering lung, liver, kidney and large intestine channels due to the fact that the mulberry is sour and cold in nature, and is suitable for symptoms such as yin and blood deficiency, dizziness, night sweat, body fluid consumption and thirst, diabetes, intestinal dryness and constipation.
Medlar: is the mature fruit of Lycium chinense Mill of Solanaceae, and the product is prepared by drying in the shade and insolating. Fructus Lycii contains betaine (betane), atropine (atropine), and henbane, and is sweet and neutral. Nourish liver, nourish kidney, moisten lung. Tonifying deficiency, replenishing vital essence, clearing heat, improving eyesight, and regulating immunity.
Rhizoma polygonati: also named: rhizoma Polygonati, herba Elsholtziae Blumeae, rhizoma Gynurae Divaricatae, etc. Is a plant of Polygonatum, a plant used for traditional Chinese medicine, and has the functions of invigorating qi, nourishing yin, invigorating spleen, tonifying kidney, moistening lung and promoting fluid production.
Glossy privet fruit: the variant is glossy privet fruit, Chinese holly fruit, waxtree and catalpa ovata, which are dry mature fruits of glossy privet of the family Oleaceae, and are sweet, bitter and cool. It belongs to liver and kidney meridians, is a Chinese medicine for tonifying kidney, nourishing yin, nourishing liver and improving eyesight, and can be used for treating liver and kidney deficiency, dizziness, tinnitus, premature graying of hair, blurred vision, etc.
Eclipta alba: generally, the snakehead gut is a plant of snakehead genus of Compositae family. Sweet and sour in flavor, cool in nature, entering liver and kidney meridians. The herbs have astringent, hemostatic, and liver and kidney tonifying effects.
Raspberry: is mature dry fruit of Rubus chingii Hu of Rosaceae. Sweet and sour in flavor and warm in nature. It enters liver, kidney and bladder meridians. Has the functions of invigorating kidney, stopping nocturnal emission, reducing urination, nourishing liver and improving eyesight. It is commonly used for seminal emission, spermatorrhea, enuresis, frequent micturition, impotence, premature ejaculation, dim eyesight and dim flower.
The invention also provides a preparation method of the anti-fatigue traditional Chinese medicine composition, which comprises the following steps:
(1) weighing the raw materials of each component respectively, and removing impurities for later use;
(2) adding water into earthworm, zaocys dhumnade, antler slices, astragalus, codonopsis pilosula, ginseng, peach kernel, safflower, salvia miltiorrhiza, ligusticum wallichii, angelica, morinda officinalis, eucommia ulmoides, epimedium herb, cistanche deserticola, cinnamon, prepared rhizome of rehmannia, medlar, rhizoma polygonati, glossy privet fruit, eclipta alba, mulberry and raspberry respectively, decocting for 2 times, decocting for 60 minutes each time, filtering, and mixing the filtrate to obtain a decoction medicine material;
(3) concentrating the decocted medicine material in the step (2) under reduced pressure to obtain a concentrated medicine material;
(4) and (4) carrying out spray drying on the concentrated medicine material obtained in the step (3) to obtain a powdery mixture, namely the traditional Chinese medicine composition.
Further, the pressure of the reduced pressure concentration in the step (3) is 0.07-0.08MPa, and the temperature is 50-60 ℃.
Further, the density of the concentrated medicine material in the step (3) is 1.25-1.32 g/ml.
Further, the obtained traditional Chinese medicine composition of the powdery mixture is further processed into powder, pills, tablets or capsules after the step (4).
Further, when the traditional Chinese medicine composition is processed into powder, auxiliary materials are further added to prepare solid beverage or liquid bottled beverage, and the auxiliary materials comprise flavoring agents, dispersing agents and/or thickening agents; or, when the Chinese medicinal composition is processed into pills, honey is further added.
The method of the invention has the following advantages:
(1) the anti-fatigue traditional Chinese medicine composition is prepared by compounding astragalus, codonopsis pilosula, ginseng, peach kernel, safflower, salvia miltiorrhiza, ligusticum wallichii, angelica sinensis, earthworm, zaocys dhumnade, morinda officinalis, eucommia ulmoides, epimedium, cistanche, cinnamon, prepared rhizome of rehmannia, antler pieces, mulberry, medlar, rhizoma polygonati, glossy privet fruit, eclipta alba and raspberry in a reasonable proportion, so that the medicine effects of the components generate a synergistic effect, and the anti-fatigue traditional Chinese medicine composition achieves the effects of enhancing the body immunity and relieving the physical fatigue of people.
(2) Can improve mental fatigue syndrome caused by excessive mental labor, physical labor or long-term mental tension, such as deficiency of energy, fatigue, lassitude, listlessness, distraction, chest distress, palpitation, insomnia, amnesia, and has remarkable treatment effect.
(3) The traditional Chinese medicine composition is easy to prepare, the preparation method has high process degree and low cost.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. Unless otherwise specified, the raw materials and equipment used in the following examples are commercially available.
Example 1
The traditional Chinese medicine composition comprises the following components in parts by weight:
20 parts of astragalus membranaceus, 15 parts of codonopsis pilosula, 15 parts of ginseng, 10 parts of peach kernel, 5 parts of safflower, 20 parts of salvia miltiorrhiza, 10 parts of ligusticum wallichii, 15 parts of angelica sinensis, 30 parts of lumbricus, 30 parts of zaocys dhumnade, 30 parts of radix morindae officinalis, 30 parts of eucommia ulmoides, 30 parts of epimedium, 30 parts of cistanche, 10 parts of cinnamon, 30 parts of prepared rehmannia rhizome, 20 parts of antler pieces, 15 parts of mulberry, 15 parts of medlar, 30 parts of rhizoma polygonati, 15 parts of glossy privet fruit, 20 parts of eclipta alba and 15 parts of raspberry.
The preparation method comprises the following steps:
(1) weighing the raw materials of each component respectively, and removing impurities for later use;
(2) adding water into earthworm, zaocys dhumnade, antler slices, astragalus, codonopsis pilosula, ginseng, peach kernel, safflower, salvia miltiorrhiza, ligusticum wallichii, angelica, morinda officinalis, eucommia ulmoides, epimedium herb, cistanche deserticola, cinnamon, prepared rhizome of rehmannia, medlar, rhizoma polygonati, glossy privet fruit, eclipta alba, mulberry and raspberry respectively, decocting for 2 times, decocting for 60 minutes each time, filtering, and mixing the filtrate to obtain a decoction medicine material;
(3) concentrating the decocted medicine material in the step (2) under reduced pressure to obtain a concentrated medicine material, wherein the density of the concentrated medicine material is 1.30 g/ml;
(4) and (4) carrying out spray drying on the concentrated medicine material obtained in the step (3) to obtain a powdery mixture, namely the traditional Chinese medicine composition.
(5) Adding honey into the powdery mixture obtained in the step (4) to prepare pills.
Example 2
The traditional Chinese medicine composition comprises the following components in parts by weight:
22 parts of astragalus membranaceus, 16 parts of codonopsis pilosula, 17 parts of ginseng, 9 parts of peach kernel, 6 parts of safflower, 18 parts of salvia miltiorrhiza, 12 parts of ligusticum wallichii, 12 parts of angelica sinensis, 28 parts of lumbricus, 28 parts of zaocys dhumnade, 33 parts of radix morindae officinalis, 28 parts of eucommia ulmoides, 32 parts of epimedium, 32 parts of cistanche, 8 parts of cinnamon, 28 parts of prepared rehmannia rhizome, 20 parts of antler slice, 16 parts of mulberry, 12 parts of medlar, 28 parts of rhizoma polygonati, 12 parts of glossy privet fruit, 18 parts of eclipta alba and 18 parts of raspberry.
The preparation method comprises the following steps:
(1) weighing the raw materials of each component respectively, and removing impurities for later use;
(2) adding water into earthworm, zaocys dhumnade, antler slices, astragalus, codonopsis pilosula, ginseng, peach kernel, safflower, salvia miltiorrhiza, ligusticum wallichii, angelica, morinda officinalis, eucommia ulmoides, epimedium herb, cistanche deserticola, cinnamon, prepared rhizome of rehmannia, medlar, rhizoma polygonati, glossy privet fruit, eclipta alba, mulberry and raspberry respectively, decocting for 2 times, decocting for 60 minutes each time, filtering, and mixing the filtrate to obtain a decoction medicine material;
(3) concentrating the decocted medicine material in the step (2) under reduced pressure to obtain a concentrated medicine material, wherein the density of the concentrated medicine material is 1.28 g/ml;
(4) and (4) carrying out spray drying on the concentrated medicine material obtained in the step (3) to obtain a powdery mixture, namely the traditional Chinese medicine composition.
(5) Adding flavoring agent, dispersant and thickener into the powder mixture of step (4) to obtain solid beverage. In another embodiment, a liquid bottled beverage is prepared.
Example 3
The traditional Chinese medicine composition comprises the following components in parts by weight:
20 parts of astragalus membranaceus, 16 parts of codonopsis pilosula, 16 parts of ginseng, 10 parts of peach kernel, 5 parts of safflower, 18 parts of salvia miltiorrhiza, 10 parts of ligusticum wallichii, 15 parts of angelica sinensis, 30 parts of lumbricus, 30 parts of zaocys dhumnade, 30 parts of radix morindae officinalis, 30 parts of eucommia ulmoides, 30 parts of epimedium, 30 parts of cistanche, 10 parts of cinnamon, 30 parts of prepared rehmannia rhizome, 20 parts of antler pieces, 16 parts of mulberry, 12 parts of medlar, 28 parts of rhizoma polygonati, 15 parts of glossy privet fruit, 18 parts of eclipta alba and 18 parts of raspberry.
The preparation method comprises the following steps:
(1) weighing the raw materials of each component respectively, and removing impurities for later use;
(2) adding water into earthworm, zaocys dhumnade, antler slices, astragalus, codonopsis pilosula, ginseng, peach kernel, safflower, salvia miltiorrhiza, ligusticum wallichii, angelica, morinda officinalis, eucommia ulmoides, epimedium herb, cistanche deserticola, cinnamon, prepared rhizome of rehmannia, medlar, rhizoma polygonati, glossy privet fruit, eclipta alba, mulberry and raspberry respectively, decocting for 2 times, decocting for 60 minutes each time, filtering, and mixing the filtrate to obtain a decoction medicine material;
(3) concentrating the decocted medicine material in the step (2) under reduced pressure to obtain a concentrated medicine material, wherein the density of the concentrated medicine material is 1.26 g/ml;
(4) and (4) carrying out spray drying on the concentrated medicine material obtained in the step (3) to obtain a powdery mixture, namely the traditional Chinese medicine composition.
(5) And (4) preparing the traditional Chinese medicine composition of the powdery mixture in the step (4) into tablets.
Example 4
The traditional Chinese medicine composition comprises the following components in parts by weight:
18 parts of astragalus membranaceus, 16 parts of codonopsis pilosula, 18 parts of ginseng, 10 parts of peach kernel, 8 parts of safflower, 18 parts of salvia miltiorrhiza, 10 parts of ligusticum wallichii, 12 parts of angelica sinensis, 26 parts of lumbricus, 26 parts of zaocys dhumnade, 28 parts of morinda officinalis, 26 parts of eucommia ulmoides, 28 parts of epimedium, 28 parts of cistanche, 10 parts of cinnamon, 26 parts of prepared rehmannia rhizome, 18 parts of antler pieces, 18 parts of mulberry, 16 parts of medlar, 30 parts of rhizoma polygonati, 16 parts of glossy privet fruit, 18 parts of eclipta alba and 18 parts of raspberry.
The preparation method comprises the following steps:
(1) weighing the raw materials of each component respectively, and removing impurities for later use;
(2) adding water into earthworm, zaocys dhumnade, antler slices, astragalus, codonopsis pilosula, ginseng, peach kernel, safflower, salvia miltiorrhiza, ligusticum wallichii, angelica, morinda officinalis, eucommia ulmoides, epimedium herb, cistanche deserticola, cinnamon, prepared rhizome of rehmannia, medlar, rhizoma polygonati, glossy privet fruit, eclipta alba, mulberry and raspberry respectively, decocting for 2 times, decocting for 60 minutes each time, filtering, and mixing the filtrate to obtain a decoction medicine material;
(3) concentrating the decocted medicine material in the step (2) under reduced pressure to obtain a concentrated medicine material, wherein the density of the concentrated medicine material is 1.25 g/ml;
(4) and (4) carrying out spray drying on the concentrated medicine material obtained in the step (3) to obtain a powdery mixture, namely the traditional Chinese medicine composition.
(5) And (4) preparing the traditional Chinese medicine composition of the powdery mixture in the step (4) into capsules.
Example 5
The traditional Chinese medicine composition comprises the following components in parts by weight:
18 parts of astragalus mongholicus, 18 parts of codonopsis pilosula, 18 parts of ginseng, 12 parts of peach kernel, 5 parts of safflower carthamus, 18 parts of salvia miltiorrhiza, 10 parts of ligusticum wallichii, 18 parts of angelica sinensis, 24 parts of lumbricus, 24 parts of zaocys dhumnade, 35 parts of radix morindae officinalis, 32 parts of eucommia ulmoides, 32 parts of epimedium, 35 parts of cistanche, 12 parts of cinnamon, 24 parts of prepared rehmannia rhizome, 22 parts of antler pieces, 18 parts of mulberry, 18 parts of medlar, 30 parts of rhizoma polygonati, 18 parts of glossy privet fruit, 18 parts of eclipta alba and 20 parts of.
The preparation method comprises the following steps:
(1) weighing the raw materials of each component respectively, and removing impurities for later use;
(2) adding water into earthworm, zaocys dhumnade, antler slices, astragalus, codonopsis pilosula, ginseng, peach kernel, safflower, salvia miltiorrhiza, ligusticum wallichii, angelica, morinda officinalis, eucommia ulmoides, epimedium herb, cistanche deserticola, cinnamon, prepared rhizome of rehmannia, medlar, rhizoma polygonati, glossy privet fruit, eclipta alba, mulberry and raspberry respectively, decocting for 2 times, decocting for 60 minutes each time, filtering, and mixing the filtrate to obtain a decoction medicine material;
(3) concentrating the decocted medicine material in the step (2) under reduced pressure to obtain a concentrated medicine material, wherein the density of the concentrated medicine material is 1.32 g/ml;
(4) and (4) carrying out spray drying on the concentrated medicine material obtained in the step (3) to obtain a powdery mixture, namely the traditional Chinese medicine composition.
(5) And (4) preparing the traditional Chinese medicine composition of the powdery mixture in the step (4) into pills.
The results of clinical trials of the Chinese medicinal composition of the present invention for treating fatigue diseases are as follows.
1. Subject of clinical observation
The immunity of the body is reduced, the physical fatigue is often felt, and the patients also have one or more symptoms of insufficient energy, fatigue and sleepiness, lassitude, distraction, chest distress, palpitation, insomnia, amnesia and the like: 80 of the patients were observed, 48 men and 32 women, all of which were adults.
2. Method of treatment
The traditional Chinese medicine composition is decocted with water for one dose, each dose is 30g, one dose is taken every day, and the decoction is taken for 3-5 times a day; or taking powder, pill, tablet or capsule made of the traditional Chinese medicine composition, 10g of each dose, three times a day. Half a month is taken continuously as a course of treatment, and 5 courses of treatment are observed at most. During the treatment period, meat and greasy food are not eaten, and liquor is not drunk.
And (4) effect judgment: the clinical fatigue symptom is completely eliminated, and the patients who do not relapse after the follow-up visit for 3 months are cured; more than 30% of fatigue symptoms are eliminated, and the patients who relapse but are lighter after follow-up for 3 months are effective; others are not.
3. Therapeutic results
68 cases of recovery, accounting for 85 percent; 12 effective cases account for 15 percent; and invalid 0 case.
The clinical test results show that the traditional Chinese medicine composition disclosed by the invention can enhance the immunity of the body, relieve the physical fatigue of people, and simultaneously improve the mental fatigue syndrome caused by excessive mental labor, physical labor or long-term mental stress, and has a remarkable treatment effect.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (7)
1. The anti-fatigue traditional Chinese medicine composition is characterized by being prepared from the following components in parts by weight:
18-25 parts of astragalus membranaceus, 12-18 parts of codonopsis pilosula, 14-18 parts of ginseng, 6-12 parts of peach kernel, 5-10 parts of safflower, 18-25 parts of salvia miltiorrhiza, 10-15 parts of ligusticum wallichii, 12-18 parts of angelica sinensis, 24-30 parts of earthworm, 24-30 parts of zaocys dhumnade, 26-35 parts of morinda officinalis, 26-32 parts of eucommia ulmoides, 26-32 parts of epimedium, 26-35 parts of cistanche, 6-12 parts of cinnamon, 24-32 parts of prepared rehmannia rhizome, 16-22 parts of antler slices, 12-18 parts of mulberry, 12-18 parts of medlar, 24-30 parts of rhizoma polygonati, 12-18 parts of glossy privet fruit, 18-24 parts of eclipta alba and 12-20 parts of raspberry;
the preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) weighing the raw materials of each component respectively, and removing impurities for later use;
(2) adding water into earthworm, zaocys dhumnade, antler slices, astragalus, codonopsis pilosula, ginseng, peach kernel, safflower, salvia miltiorrhiza, ligusticum wallichii, angelica, morinda officinalis, eucommia ulmoides, epimedium herb, cistanche deserticola, cinnamon, prepared rhizome of rehmannia, medlar, rhizoma polygonati, glossy privet fruit, eclipta alba, mulberry and raspberry respectively, decocting for 2 times, decocting for 60 minutes each time, filtering, and mixing the filtrate to obtain a decoction medicine material;
(3) concentrating the decocted medicine material in the step (2) under reduced pressure to obtain a concentrated medicine material;
(4) spray drying the concentrated medicinal material obtained in the step (3) to obtain a powdery mixture, namely the traditional Chinese medicine composition;
in the step (3), the pressure of the reduced pressure concentration is 0.07-0.08MPa, and the temperature is 50-60 ℃;
the density of the concentrated medicine in the step (3) is 1.25-1.32 g/ml.
2. The traditional Chinese medicine composition as claimed in claim 1, wherein the traditional Chinese medicine composition is prepared from the following components in parts by weight:
18-23 parts of astragalus membranaceus, 13-16 parts of codonopsis pilosula, 15-18 parts of ginseng, 6-10 parts of peach kernel, 5-8 parts of safflower, 18-22 parts of salvia miltiorrhiza, 10-14 parts of ligusticum wallichii, 12-16 parts of angelica sinensis, 26-30 parts of lumbricus, 26-30 parts of zaocys dhumnade, 28-34 parts of radix morindae officinalis, 26-30 parts of eucommia ulmoides, 28-32 parts of epimedium, 28-33 parts of cistanche, 6-11 parts of cinnamon, 26-31 parts of prepared rehmannia rhizome, 17-21 parts of antler slices, 13-18 parts of mulberry, 12-16 parts of medlar, 26-30 parts of rhizoma polygonati, 12-16 parts of glossy privet fruit, 18-22 parts of eclipta alba and 12-18 parts of raspberry.
3. The traditional Chinese medicine composition as claimed in claim 1, wherein the traditional Chinese medicine composition is prepared from the following components in parts by weight:
20-22 parts of astragalus membranaceus, 14-16 parts of codonopsis pilosula, 15-17 parts of ginseng, 8-10 parts of peach kernels, 5-6 parts of safflower, 18-20 parts of salvia miltiorrhiza, 10-13 parts of ligusticum wallichii, 12-15 parts of angelica sinensis, 28-30 parts of lumbricus, 28-30 parts of zaocys dhumnade, 30-34 parts of morinda officinalis, 28-30 parts of eucommia ulmoides, 30-32 parts of epimedium, 30-32 parts of cistanche, 8-10 parts of cinnamon, 28-30 parts of prepared rehmannia rhizome, 18-20 parts of antler slices, 14-16 parts of mulberries, 12-15 parts of lycium barbarum, 28-30 parts of polygonatum kingianum, 12-15 parts of glossy privet fruits, 18-20 parts of eclipta alba and 15-18 parts of.
4. The traditional Chinese medicine composition as claimed in claim 1, wherein the traditional Chinese medicine composition is prepared from the following components in parts by weight:
20 parts of astragalus membranaceus, 15 parts of codonopsis pilosula, 15 parts of ginseng, 10 parts of peach kernel, 5 parts of safflower, 20 parts of salvia miltiorrhiza, 10 parts of ligusticum wallichii, 15 parts of angelica sinensis, 30 parts of lumbricus, 30 parts of zaocys dhumnade, 30 parts of radix morindae officinalis, 30 parts of eucommia ulmoides, 30 parts of epimedium, 30 parts of cistanche, 10 parts of cinnamon, 30 parts of prepared rehmannia rhizome, 20 parts of antler pieces, 15 parts of mulberry, 15 parts of medlar, 30 parts of rhizoma polygonati, 15 parts of glossy privet fruit, 20 parts of eclipta alba and 15 parts of raspberry.
5. The traditional Chinese medicine composition as claimed in claim 1, wherein the traditional Chinese medicine composition is prepared from the following components in parts by weight:
22 parts of astragalus membranaceus, 16 parts of codonopsis pilosula, 17 parts of ginseng, 9 parts of peach kernel, 6 parts of safflower, 18 parts of salvia miltiorrhiza, 12 parts of ligusticum wallichii, 12 parts of angelica sinensis, 28 parts of lumbricus, 28 parts of zaocys dhumnade, 33 parts of radix morindae officinalis, 28 parts of eucommia ulmoides, 32 parts of epimedium, 32 parts of cistanche, 8 parts of cinnamon, 28 parts of prepared rehmannia rhizome, 20 parts of antler slice, 16 parts of mulberry, 12 parts of medlar, 28 parts of rhizoma polygonati, 12 parts of glossy privet fruit, 18 parts of eclipta alba and 18 parts of raspberry.
6. The preparation method according to claim 1, wherein the obtained Chinese medicinal composition of the powdery mixture is further processed into powder, pill, tablet or capsule after step (4).
7. The preparation method according to claim 6, wherein after the Chinese medicinal composition is processed into powder, the powder is further added with adjuvants to prepare solid beverage or liquid bottled beverage, wherein the adjuvants are selected from one or more of flavoring agent, dispersing agent and/or thickening agent; or, when the Chinese medicinal composition is processed into pills, honey is further added.
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| CN105273950A (en) * | 2015-11-13 | 2016-01-27 | 刘炳兴 | Zhuangyang wine and making method thereof |
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