CN104758736A - Blood-glucose-reducing traditional Chinese medicine composition and preparation method thereof - Google Patents
Blood-glucose-reducing traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The invention provides a blood-glucose-reducing traditional Chinese medicine composition and a preparation method thereof. The composition comprises gynostemma pentaphylla, jasmine, Chinese yam, radix polygonati officinalis, polygonum multiflorum, wolfberry, Chinese angelica, gingko leaf, mint, ginseng beard, astragalus, poria cocos, anemarrhenae, Chinese angelica, ligusticum wallichii, salviae miltiorrhizae, red peony root, rhizoma alismatis, malt, radix trichosanthis, rehmannia, rhizoma polygonati, radix ophiopogonis, dendrobe, puerarin, eucommia ulmoides, cornus officinalis, gorgon fruit, schisandra chinensis, cortex lycii radicis, Sichuan fritillary bulb, honeysuckle, rhizoma curculiginis, blackend swallowwort root, madder, semen cassia and fructus chebulae. The preparation method comprises the following steps: uniformly mixing the components, crushing the components into crude powder, performing supercritical CO2 extraction, adsorbing obtained extracting liquor by macroporous adsorption resin, eluting by an alcohol aqueous solution, filtering eluant with an ultrafiltration membrane, concentrating, and drying to obtain the traditional Chinese medicine composition. The blood-glucose-reducing traditional Chinese medicine composition disclosed by the invention can be used for effectively reducing blood glucose, has a blood glucose reducing effect which is much higher than that of an existing drug, and can be widely used for preparing a drug for treating diabetes.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, be specifically related to a kind of sugar-reduction traditional Chinese medicine composition and preparation method thereof.
Background technology
Along with the improvement of Chinese society economic condition, improving constantly of living standards of the people, the change of dietary structure, the attenuating of labor intensity, crowd's average life extends, and stress state increases, and the improvement of diabetes detection means, diabetes prevalence is rising gradually, according to statistics, every 10 clocks in the whole world just have 1 people to die from diabetes-associated disease, arrange the 4th in global main vital disease, within 2007, the whole world about 3,800 ten thousand people dies from diabetes, accounts for 6% of whole world general mortality rate.The mortality rate of this numeral about with 2002 years acquired immune deficiency syndrome (AIDS) is suitable.
The impact of diabetes on our people's health is also on the rise.Though China belongs to the low prevalence country of diabetes in the world, the number of diabetics has occupied second place of the world (being only second to the U.S.), gathers way surprising.China's diabetics sum about 3,600 ten thousand people according to the preliminary statistics, wherein the patient of type Ⅰ diabetes mellitus accounts for 5%, sum about 2,000,000 people, and the sickness rate of China's type Ⅰ diabetes mellitus is about 0.7 ~ 1.0/10 ten thousand.The prevalence of China's type Ⅱdiabetes mellitus increases very fast, according to investigation in China 300,000 population in 1979, diabetes prevalence is 0.6%, within 1989, be 2.02%, average annual growth about 0.1%, China's generaI investigation 200,000 populations in 1994, prevalence rises to 2.5%, and in current 20 ~ 75 years old crowd, diabetes prevalence is about about 3%.Patients with impaired glucose tolerance is not less than 3%.
Diabetes can cause many serious complication, comprise blind, renal failure, neuropathy, cardiovascular disease and limb ischemia downright bad etc.Unfortunately, the diabetics about more than 50% does not recognize the harm of these complication, in some this ratio of country even up to 80%.Therefore, the whole society has to spend tens million of dollar for due to non-early diagnosis or the severe complication that do not obtain regular treatment and cause every year.The financial burden that diabetes are brought is huge and heavy.In 2007, the whole world was used for the treatment of about 2,320 hundred million dollars of the expense of diabetes, will reach 3,020 hundred million in 2025.By strengthening the prevention, particularly early diagnosis of diabetes, nursing one's health in early days, avoiding the generation of diabetes-related complication, is reduce onset diabetes rate and medical expense the best way.
The chronic complicating diseases of diabetes is main causes that patient is lethal, disable.The genesis mechanism of its complication is very complicated, Chinese scholars is own to be formed aspects such as removing imbalance be studied from albumen nonenzymatic glycosylation, polyhydric alcohol path Developmental and Metabolic Disorder, free radical, and think that these several respects influence each other, but still owe desirable to the treatment means of chronic complicating diseases, existing being mainly conceived to controls in the prevention of blood glucose, early diagnosis, risk factor.Main Function as lattice train urea promotes insulin secretion, also can promote that peripheral tissues is to the effect of insulin, but it is durative action preparation, easily accumulates in vivo, can cause intractable hypoglycemic generation.It is obvious to blood sugar decreasing effect, but not evidence suggests preventing or delaying the generation of complication and development has obvious effect.
Existing reduction blood glucose method is all generally use the secretion of nonencapsulated islets element or exogenous increase islets of langerhans and usually control blood glucose, and cannot realize the self regulation of blood glucose, long-term prescription blood glucose is fluctuated, and drug side effect is large at all.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art and provide a kind of sugar-reduction traditional Chinese medicine composition and preparation method thereof, said composition has significantly and stable function of reducing blood sugar.
A kind of sugar-reduction traditional Chinese medicine composition, comprise with parts by weight: Herb Gynostemmae Pentaphylli 2 ~ 9 parts, Fructus Gardeniae 1 ~ 7 part, Rhizoma Dioscoreae 3 ~ 8 parts, Rhizoma Polygonati Odorati 1 ~ 5 part, Radix Polygoni Multiflori 2 ~ 8 parts, Fructus Lycii 1 ~ 7 part, Radix Angelicae Sinensis 2 ~ 9 parts, Folium Ginkgo 3 ~ 9 parts, Herba Menthae 1 ~ 8 part, Leptoradix Ginseng 2 ~ 7 parts, the Radix Astragali 1 ~ 6 part, 3 ~ 8 parts, Poria, the Rhizoma Anemarrhenae 4 ~ 12 parts, Radix Angelicae Sinensis 1 ~ 7 part, Rhizoma Chuanxiong 2 ~ 9 parts, Radix Salviae Miltiorrhizae 2 ~ 10 parts, Radix Paeoniae Rubra 1 ~ 8 part, Rhizoma Alismatis 2 ~ 9 parts, 4 ~ 10 parts, Fructus Hordei Germinatus, Radix Trichosanthis 2 ~ 8 parts, Radix Rehmanniae 1 ~ 7 part, Rhizoma Polygonati 3 ~ 8 parts, Radix Ophiopogonis 2 ~ 7 parts, Herba Dendrobii 4 ~ 12 parts, Radix Puerariae 3 ~ 9 parts, the Cortex Eucommiae 2 ~ 8 parts, Fructus Corni 3 ~ 7 parts, Semen Euryales 1 ~ 9 part, Fructus Schisandrae Chinensis 2 ~ 8 parts, Cortex Lycii 3 ~ 10 parts, Bulbus Fritillariae Cirrhosae 4 ~ 9 parts, Flos Lonicerae 1 ~ 6 part, Rhizoma Curculiginis 1 ~ 9 part, Radix Cynanchi Atrati 3 ~ 6 parts, 2 ~ 8 parts, Radix Rubiae, Semen Cassiae 1 ~ 9 part, Fructus Chebulae 4 ~ 12 parts.
Herb Gynostemmae Pentaphylli: bitter in the mouth, micro-sweet, cool in nature.Return lung, spleen, kidney channel.There is effect of heat clearing away, tonify deficiency, removing toxic substances.Cure mainly that body void is weak, nephrasthenia emission, leukopenia, hyperlipemia, viral hepatitis, chronic gastroenteritis, chronic tracheitis.
Fructus Gardeniae: property is bitter, cold.GUIXIN, liver, lung, stomach, tri-jiao channel.There is effect of pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Cure mainly that calentura is vexed, liver-fire conjunctival congestion, headache, damp and hot yellow infantile malnutrition, stranguria, leaf blood epistaxis, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprain and swell and ache.
Rhizoma Polygonati Odorati: nature and flavor, sweet, flat.Attach to the lung and stomach meridians.There is effect of nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid.Cure mainly cough caused by dryness, chronic cough, the dry throat and mouth of calentura cloudy liquid consumption wound, interior-heat are quenched one's thirst, deficiency of YIN diseases caused by exogenous pathogenic factor, dizzy, the muscle arteries and veins spasm and pain of giddy.
Radix Polygoni Multiflori: nature and flavor are bitter, sweet, puckery, slightly warm in nature.Return liver, kidney channel.There is nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, dispel the wind, detoxify.Cure mainly blood deficiency Light-headedness, cardiopalmus, insomnia, the soreness of the waist and knees of the hepatic and renal YIN deficiency, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, chronic malaria body void, rubella pruritus, carbuncle sore, scrofula, hemorrhoid.
The Radix Astragali: nature and flavor are sweet, warm.GUIXIN, lung, spleen, kidney channel.There is effect of invigorating QI to consolidate the body surface resistance, diuresis, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing.Cure mainly impractical swollen, chronic nephritis, the carbuncle difficulty of cardiopalmus of breathing hard, asthenia, weak, spontaneous perspiration, night sweat, chronic diarrhea, proctoptosis, uterine prolapse, body to burst or burst and do not hold back for a long time.
Poria: nature and flavor are sweet, light, flat.GUIXIN, spleen, lung, kidney channel.There is effect of eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.Cure mainly dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, have loose bowels, palpitation and restlessness, insomnia forgetfulness, seminal emission nebulousurine.
The Rhizoma Anemarrhenae: bitter in the mouth, cold in nature.Return lung, stomach, kidney channel.There is effect of clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, relieving restlessness of quenching the thirst.Cure mainly epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, stranguria with turbid discharge of quenching one's thirst.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.There is effect of blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping.Cure mainly that menoxenia, amenorrhea dysmenorrhea, the stasis of blood in puerperal stagnant raw meat Tong, mass in the abdomen lump, pain in chest and hypochondrium, headache are dizzy, anemofrigid-damp arthralgia, traumatic injury, ulcer sores.
Radix Paeoniae Rubra: property is bitter, be slightly cold.Return liver, spleen channel.There is effect of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Cure mainly maculae caused by violent heat pathogen, hematemesis and epistaxis, discharging fresh blood stool, conjunctival congestion and swelling pain, carbuncle skin infection, amenorrhea, dysmenorrhea, metrorrhagia and leukorrhagia stranguria with turbid discharge, the stagnant hypochondriac pain of the stasis of blood, hernia abdominal mass are gathered, injury from falling down.
Radix Trichosanthis: sweet in the mouth, micro-hardship, cold nature.Attach to the lung and stomach meridians.There is clearing away heat and promoting production of body fluid, moistening the lung and resolving phlegm, detumescence arrange dense effect.Cure mainly that calentura is thirsty, polydipsia of quenching one's thirst, lung-heat type cough, sore swollen toxin.
Radix Rehmanniae: sweet in the mouth, hardship, be slightly cold.GUIXIN, liver, kidney channel.There is nourishing YIN and clearing away heat, effect that removing heat from blood is enriched blood.Cure mainly calentura excessive thirst, interior-heat quenched one's thirst, hectic fever due to YIN-deficiency consumptive fever, epidemic febrile disease send out haematemesis, metrorrhagia, hematuria caused by speckle, heat in blood, have blood in stool, blood deficiency and yellow complexion, dizzy cardiopalmus, insufficiency of blood amenorrhea.
Rhizoma Polygonati: nature and flavor are sweet, flat.Return spleen, lung, kidney channel.There is effect of nourishing YIN and moistening the lung, invigorating the spleen and replenishing QI, Zishen fill fine.Cure mainly deficiency of YIN chronic cough, xeropulmonary cough, insufficiency of the spleen weak, lack of appetite xerostomia, quench one's thirst, deficiency of the kidney soreness of the waist and knees, impotence and seminal emission, tinnitus order are dark, early whitening of beard and hair, body void wins thin, wind favus disease.
Herba Dendrobii: nature and flavor are sweet, be slightly cold.Return stomach, lung, kidney channel.There is effect of the stomach reinforcing that promotes the production of body fluid, nourishing YIN and clearing away heat, lung moistening kidney tonifying, the strong waist of improving eyesight.Cure mainly consumption of body fluid caused by febrile disease, xerostomia excessive thirst, deficiency of stomach-Yin, stomachache retch, dryness of the lung dry cough, deficiency-heat are not moved back, the moon hinders that order is dark, waist knee joint is weak.
Cortex Lycii: sweet in the mouth, cold in nature.Return lung, kidney channel.There is effect of clearind deficient heat, purte the white, removing heat from blood.Cure mainly hectic fever due to deficiency of YIN, hectic fever due to YIN-deficiency night sweat, infantile malnutrition heating, dyspnea and cough due to lung-heat, haematemesis, epistaxis, hematuria, quench one's thirst.
Radix Cynanchi Atrati: bitter in the mouth, salty, cold in nature.Return lung, stomach, Liver Channel.There is effect of heat clearing away tonifying YIN, inducing diuresis for treating stranguria syndrome, detoxification sore treatment.Cure mainly warm, fever of the body macule, hectic fever hectic fever due to YIN-deficiency, cough due to lung-heat, puerperal fidgets due to deficiency, pyretic stranguria, stranguria with blood, laryngopharynx swelling and pain, sore and toxic, venom.
Radix Rubiae: nature and flavor are bitter, cold returns liver, heart channel.Return liver, the heart, kidney, spleen, stomach, pericardium channel.There is effect of cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling.Cure mainly heat in blood spitting of blood, haematemesis, epistaxis, hematuria, have blood in stool, metrorrhagia, amenorrhea, postpartum stagnation stomachache, traumatic injury, rheumatic arthralgia, jaundice, carbuncle sore, hemorrhoid swell.
The preparation method of above-mentioned sugar-reduction traditional Chinese medicine composition, comprises the following steps:
Step 1, get Herb Gynostemmae Pentaphylli, Fructus Gardeniae, Rhizoma Dioscoreae, Rhizoma Polygonati Odorati, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, Folium Ginkgo, Herba Menthae, Leptoradix Ginseng, the Radix Astragali, Poria, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Alismatis, Fructus Hordei Germinatus, Radix Trichosanthis, Radix Rehmanniae, Rhizoma Polygonati, Radix Ophiopogonis, Herba Dendrobii, Radix Puerariae, the Cortex Eucommiae, Fructus Corni, Semen Euryales, Fructus Schisandrae Chinensis, Cortex Lycii, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Rhizoma Curculiginis, Radix Cynanchi Atrati, Radix Rubiae, Semen Cassiae and Fructus Chebulae, after mix homogeneously, be ground into coarse powder, carry out supercritical CO
2extraction, collects extract;
Step 2, adsorbs step 1 gained extract through macroporous adsorbent resin, then carries out eluting with ethanol water, obtain eluent;
Step 3, by step 2 gained eluent after ultrafiltration membrance filter, concentrated, dry, obtain Chinese medicine composition.
As the further improvement of foregoing invention, when the yellow wine system of being classified as, concocting step is: Radix Angelicae Sinensis adds yellow wine and mixes thoroughly, after vexed, and parch at 210 ~ 220 DEG C.
As the further improvement of foregoing invention, supercritical CO in step 1
2the pressure of extraction is 20 ~ 45MPa, and temperature is 25 ~ 50 DEG C, and extraction time is 3 ~ 5h.
As the further improvement of foregoing invention, macroporous adsorbent resin described in step 2 is selected from AB-8, NKA, HDP-100, HDP-722 or HDP-750.
As the further improvement of foregoing invention, in step 2, the concentration of ethanol water is 60 ~ 90wt.%.
As the further improvement of foregoing invention, the molecular cut off of ultrafilter membrane described in step 3 is 100000 ~ 200000Da.
As the further improvement of foregoing invention, dry in step 3 is lyophilization or spraying dry.
Sugar-reduction traditional Chinese medicine composition of the present invention, between each component, compatibility is reasonable, jointly plays synergism, demonstrates significantly and stable function of reducing blood sugar.The concocting method of Radix Angelicae Sinensis is infiltrated by common clear water, dry and be adjusted to yellow wine system after, effectively can get rid of the impurity component in Radix Angelicae Sinensis, improve separating degree when absorption with macroporous adsorbent resin is separated, improve drug effect.
Detailed description of the invention
Embodiment 1
A kind of sugar-reduction traditional Chinese medicine composition, comprise with parts by weight: Herb Gynostemmae Pentaphylli 2 parts, Fructus Gardeniae 1 part, Rhizoma Dioscoreae 3 parts, Rhizoma Polygonati Odorati 1 part, Radix Polygoni Multiflori 2 parts, Fructus Lycii 1 part, Radix Angelicae Sinensis 2 parts, Folium Ginkgo 3 parts, Herba Menthae 1 part, Leptoradix Ginseng 2 parts, the Radix Astragali 1 part, 3 parts, Poria, the Rhizoma Anemarrhenae 4 parts, Radix Angelicae Sinensis 1 part, Rhizoma Chuanxiong 2 parts, Radix Salviae Miltiorrhizae 2 parts, Radix Paeoniae Rubra 1 part, Rhizoma Alismatis 2 parts, 4 parts, Fructus Hordei Germinatus, Radix Trichosanthis 2 parts, Radix Rehmanniae 1 part, Rhizoma Polygonati 3 parts, Radix Ophiopogonis 2 parts, Herba Dendrobii 4 parts, Radix Puerariae 3 parts, the Cortex Eucommiae 2 parts, Fructus Corni 3 parts, Semen Euryales 1 part, Fructus Schisandrae Chinensis 2 parts, Cortex Lycii 3 parts, Bulbus Fritillariae Cirrhosae 4 parts, Flos Lonicerae 1 part, Rhizoma Curculiginis 1 part, Radix Cynanchi Atrati 3 parts, 2 parts, Radix Rubiae, Semen Cassiae 1 part, Fructus Chebulae 4 parts.
The preparation method of above-mentioned sugar-reduction traditional Chinese medicine composition, comprises the following steps:
Step 1, get Herb Gynostemmae Pentaphylli, Fructus Gardeniae, Rhizoma Dioscoreae, Rhizoma Polygonati Odorati, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, Folium Ginkgo, Herba Menthae, Leptoradix Ginseng, the Radix Astragali, Poria, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Alismatis, Fructus Hordei Germinatus, Radix Trichosanthis, Radix Rehmanniae, Rhizoma Polygonati, Radix Ophiopogonis, Herba Dendrobii, Radix Puerariae, the Cortex Eucommiae, Fructus Corni, Semen Euryales, Fructus Schisandrae Chinensis, Cortex Lycii, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Rhizoma Curculiginis, Radix Cynanchi Atrati, Radix Rubiae, Semen Cassiae and Fructus Chebulae, after mix homogeneously, be ground into coarse powder, carry out supercritical CO
2extraction, extracting pressure is 20MPa, and temperature is 25 DEG C, and extraction time is 3h.Collect extract;
Step 2, adsorbs step 1 gained extract through AB-8 macroporous adsorbent resin, then carries out eluting with 60wt.% ethanol water, obtain eluent;
Step 3, by step 2 gained eluent after ultrafiltration membrance filter, the molecular cut off of ultrafilter membrane is 100000Da, and concentrated, lyophilization, obtains Chinese medicine composition.
Embodiment 2
A kind of sugar-reduction traditional Chinese medicine composition, comprise with parts by weight: Herb Gynostemmae Pentaphylli 4 parts, Fructus Gardeniae 2 parts, Rhizoma Dioscoreae 6 parts, Rhizoma Polygonati Odorati 3 parts, Radix Polygoni Multiflori 5 parts, Fructus Lycii 2 parts, Radix Angelicae Sinensis 4 parts, Folium Ginkgo 8 parts, Herba Menthae 6 parts, Leptoradix Ginseng 4 parts, the Radix Astragali 2 parts, 5 parts, Poria, the Rhizoma Anemarrhenae 10 parts, Radix Angelicae Sinensis 6 parts, Rhizoma Chuanxiong 5 parts, Radix Salviae Miltiorrhizae 3 parts, Radix Paeoniae Rubra 2 parts, Rhizoma Alismatis 4 parts, 9 parts, Fructus Hordei Germinatus, Radix Trichosanthis 3 parts, Radix Rehmanniae 4 parts, Rhizoma Polygonati 6 parts, Radix Ophiopogonis 5 parts, Herba Dendrobii 11 parts, Radix Puerariae 8 parts, the Cortex Eucommiae 6 parts, Fructus Corni 5 parts, Semen Euryales 4 parts, Fructus Schisandrae Chinensis 3 parts, Cortex Lycii 7 parts, Bulbus Fritillariae Cirrhosae 6 parts, Flos Lonicerae 2 parts, Rhizoma Curculiginis 3 parts, Radix Cynanchi Atrati 5 parts, 7 parts, Radix Rubiae, Semen Cassiae 4 parts, Fructus Chebulae 10 parts.
The preparation method of above-mentioned sugar-reduction traditional Chinese medicine composition, comprises the following steps:
Step 1, get Herb Gynostemmae Pentaphylli, Fructus Gardeniae, Rhizoma Dioscoreae, Rhizoma Polygonati Odorati, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, Folium Ginkgo, Herba Menthae, Leptoradix Ginseng, the Radix Astragali, Poria, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Alismatis, Fructus Hordei Germinatus, Radix Trichosanthis, Radix Rehmanniae, Rhizoma Polygonati, Radix Ophiopogonis, Herba Dendrobii, Radix Puerariae, the Cortex Eucommiae, Fructus Corni, Semen Euryales, Fructus Schisandrae Chinensis, Cortex Lycii, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Rhizoma Curculiginis, Radix Cynanchi Atrati, Radix Rubiae, Semen Cassiae and Fructus Chebulae, after mix homogeneously, be ground into coarse powder, carry out supercritical CO
2extraction, extracting pressure is 25MPa, and temperature is 30 DEG C, and extraction time is 4h.Collect extract;
Step 2, adsorbs step 1 gained extract through NKA macroporous adsorbent resin, then carries out eluting with 70wt.% ethanol water, obtain eluent;
Step 3, by step 2 gained eluent after ultrafiltration membrance filter, the molecular cut off of ultrafilter membrane is 100000Da, and concentrated, lyophilization, obtains Chinese medicine composition.
Embodiment 3
A kind of sugar-reduction traditional Chinese medicine composition, comprise with parts by weight: Herb Gynostemmae Pentaphylli 8 parts, Fructus Gardeniae 3 parts, Rhizoma Dioscoreae 6 parts, Rhizoma Polygonati Odorati 4 parts, Radix Polygoni Multiflori 3 parts, Fructus Lycii 2 parts, Radix Angelicae Sinensis 8 parts, Folium Ginkgo 6 parts, Herba Menthae 2 parts, Leptoradix Ginseng 5 parts, the Radix Astragali 4 parts, 6 parts, Poria, the Rhizoma Anemarrhenae 6 parts, Radix Angelicae Sinensis 4 parts, Rhizoma Chuanxiong 3 parts, Radix Salviae Miltiorrhizae 8 parts, Radix Paeoniae Rubra 3 parts, Rhizoma Alismatis 6 parts, 9 parts, Fructus Hordei Germinatus, Radix Trichosanthis 6 parts, Radix Rehmanniae 2 parts, Rhizoma Polygonati 5 parts, Radix Ophiopogonis 4 parts, Herba Dendrobii 10 parts, Radix Puerariae 6 parts, the Cortex Eucommiae 5 parts, Fructus Corni 5 parts, Semen Euryales 8 parts, Fructus Schisandrae Chinensis 6 parts, Cortex Lycii 9 parts, Bulbus Fritillariae Cirrhosae 7 parts, Flos Lonicerae 5 parts, Rhizoma Curculiginis 7 parts, Radix Cynanchi Atrati 4 parts, 5 parts, Radix Rubiae, Semen Cassiae 3 parts, Fructus Chebulae 11 parts.
The preparation method of above-mentioned sugar-reduction traditional Chinese medicine composition, comprises the following steps:
Step 1, get Herb Gynostemmae Pentaphylli, Fructus Gardeniae, Rhizoma Dioscoreae, Rhizoma Polygonati Odorati, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, Folium Ginkgo, Herba Menthae, Leptoradix Ginseng, the Radix Astragali, Poria, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Alismatis, Fructus Hordei Germinatus, Radix Trichosanthis, Radix Rehmanniae, Rhizoma Polygonati, Radix Ophiopogonis, Herba Dendrobii, Radix Puerariae, the Cortex Eucommiae, Fructus Corni, Semen Euryales, Fructus Schisandrae Chinensis, Cortex Lycii, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Rhizoma Curculiginis, Radix Cynanchi Atrati, Radix Rubiae, Semen Cassiae and Fructus Chebulae, after mix homogeneously, be ground into coarse powder, carry out supercritical CO
2extraction, extracting pressure is 35MPa, and temperature is 40 DEG C, and extraction time is 4h.Collect extract;
Step 2, adsorbs step 1 gained extract through HDP-100 macroporous adsorbent resin, then carries out eluting with 80wt.% ethanol water, obtain eluent;
Step 3, by step 2 gained eluent after ultrafiltration membrance filter, the molecular cut off of ultrafilter membrane is 1200000Da, and concentrated, spraying dry, obtains Chinese medicine composition.
Embodiment 4
A kind of sugar-reduction traditional Chinese medicine composition, comprise with parts by weight: Herb Gynostemmae Pentaphylli 5 parts, Fructus Gardeniae 3 parts, Rhizoma Dioscoreae 6 parts, Rhizoma Polygonati Odorati 2 parts, Radix Polygoni Multiflori 7 parts, Fructus Lycii 6 parts, Radix Angelicae Sinensis 8 parts, Folium Ginkgo 6 parts, Herba Menthae 2 parts, Leptoradix Ginseng 4 parts, the Radix Astragali 5 parts, 6 parts, Poria, the Rhizoma Anemarrhenae 9 parts, Radix Angelicae Sinensis 5 parts, Rhizoma Chuanxiong 7 parts, Radix Salviae Miltiorrhizae 8 parts, Radix Paeoniae Rubra 2 parts, Rhizoma Alismatis 7 parts, 8 parts, Fructus Hordei Germinatus, Radix Trichosanthis 7 parts, Radix Rehmanniae 2 parts, Rhizoma Polygonati 6 parts, Radix Ophiopogonis 3 parts, Herba Dendrobii 8 parts, Radix Puerariae 7 parts, the Cortex Eucommiae 6 parts, Fructus Corni 5 parts, Semen Euryales 3 parts, Fructus Schisandrae Chinensis 6 parts, Cortex Lycii 9 parts, Bulbus Fritillariae Cirrhosae 7 parts, Flos Lonicerae 2 parts, Rhizoma Curculiginis 8 parts, Radix Cynanchi Atrati 4 parts, 7 parts, Radix Rubiae, Semen Cassiae 3 parts, Fructus Chebulae 6 parts.
The preparation method of above-mentioned sugar-reduction traditional Chinese medicine composition, comprises the following steps:
Step 1, get Herb Gynostemmae Pentaphylli, Fructus Gardeniae, Rhizoma Dioscoreae, Rhizoma Polygonati Odorati, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, Folium Ginkgo, Herba Menthae, Leptoradix Ginseng, the Radix Astragali, Poria, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Alismatis, Fructus Hordei Germinatus, Radix Trichosanthis, Radix Rehmanniae, Rhizoma Polygonati, Radix Ophiopogonis, Herba Dendrobii, Radix Puerariae, the Cortex Eucommiae, Fructus Corni, Semen Euryales, Fructus Schisandrae Chinensis, Cortex Lycii, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Rhizoma Curculiginis, Radix Cynanchi Atrati, Radix Rubiae, Semen Cassiae and Fructus Chebulae, after mix homogeneously, be ground into coarse powder, carry out supercritical CO
2extraction, extracting pressure is 45MPa, and temperature is 30 DEG C, and extraction time is 3h.Collect extract;
Step 2, adsorbs step 1 gained extract through HDP-750 macroporous adsorbent resin, then carries out eluting with 960wt.% ethanol water, obtain eluent;
Step 3, by step 2 gained eluent after ultrafiltration membrance filter, the molecular cut off of ultrafilter membrane is 100000Da, and concentrated, lyophilization, obtains Chinese medicine composition.
Embodiment 5
A kind of sugar-reduction traditional Chinese medicine composition, comprise with parts by weight: Herb Gynostemmae Pentaphylli 9 parts, Fructus Gardeniae 7 parts, Rhizoma Dioscoreae 8 parts, Rhizoma Polygonati Odorati 5 parts, Radix Polygoni Multiflori 8 parts, Fructus Lycii 7 parts, Radix Angelicae Sinensis 9 parts, Folium Ginkgo 9 parts, Herba Menthae 8 parts, Leptoradix Ginseng 7 parts, the Radix Astragali 6 parts, 8 parts, Poria, the Rhizoma Anemarrhenae 12 parts, Radix Angelicae Sinensis 7 parts, Rhizoma Chuanxiong 9 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Paeoniae Rubra 8 parts, Rhizoma Alismatis 9 parts, 10 parts, Fructus Hordei Germinatus, Radix Trichosanthis 8 parts, Radix Rehmanniae 7 parts, Rhizoma Polygonati 8 parts, Radix Ophiopogonis 7 parts, Herba Dendrobii 12 parts, Radix Puerariae 9 parts, the Cortex Eucommiae 8 parts, Fructus Corni 7 parts, Semen Euryales 9 parts, Fructus Schisandrae Chinensis 8 parts, Cortex Lycii 10 parts, Bulbus Fritillariae Cirrhosae 9 parts, Flos Lonicerae 6 parts, Rhizoma Curculiginis 9 parts, Radix Cynanchi Atrati 6 parts, 8 parts, Radix Rubiae, Semen Cassiae 9 parts, Fructus Chebulae 12 parts.
The preparation method of above-mentioned sugar-reduction traditional Chinese medicine composition, comprises the following steps:
Step 1, get Herb Gynostemmae Pentaphylli, Fructus Gardeniae, Rhizoma Dioscoreae, Rhizoma Polygonati Odorati, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, Folium Ginkgo, Herba Menthae, Leptoradix Ginseng, the Radix Astragali, Poria, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Alismatis, Fructus Hordei Germinatus, Radix Trichosanthis, Radix Rehmanniae, Rhizoma Polygonati, Radix Ophiopogonis, Herba Dendrobii, Radix Puerariae, the Cortex Eucommiae, Fructus Corni, Semen Euryales, Fructus Schisandrae Chinensis, Cortex Lycii, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Rhizoma Curculiginis, Radix Cynanchi Atrati, Radix Rubiae, Semen Cassiae and Fructus Chebulae, after mix homogeneously, be ground into coarse powder, carry out supercritical CO
2extraction, extracting pressure is 45MPa, and temperature is 50 DEG C, and extraction time is 5h.Collect extract;
Step 2, adsorbs step 1 gained extract through HDP-722 macroporous adsorbent resin, then carries out eluting with 90wt.% ethanol water, obtain eluent;
Step 3, by step 2 gained eluent after ultrafiltration membrance filter, the molecular cut off of ultrafilter membrane is 200000Da, and concentrated, spraying dry, obtains Chinese medicine composition.
Embodiment 6
Be with the difference of embodiment 3: when the yellow wine system of being classified as, concocting step is: Radix Angelicae Sinensis adds yellow wine and mixes thoroughly, after vexed, and parch at 210 ~ 220 DEG C.
Sugar-reduction traditional Chinese medicine composition, comprise with parts by weight: Herb Gynostemmae Pentaphylli 8 parts, Fructus Gardeniae 3 parts, Rhizoma Dioscoreae 6 parts, Rhizoma Polygonati Odorati 4 parts, Radix Polygoni Multiflori 3 parts, Fructus Lycii 2 parts, Radix Angelicae Sinensis (yellow wine system) 8 parts, Folium Ginkgo 6 parts, Herba Menthae 2 parts, Leptoradix Ginseng 5 parts, the Radix Astragali 4 parts, 6 parts, Poria, the Rhizoma Anemarrhenae 6 parts, Radix Angelicae Sinensis 4 parts, Rhizoma Chuanxiong 3 parts, Radix Salviae Miltiorrhizae 8 parts, Radix Paeoniae Rubra 3 parts, Rhizoma Alismatis 6 parts, 9 parts, Fructus Hordei Germinatus, Radix Trichosanthis 6 parts, Radix Rehmanniae 2 parts, Rhizoma Polygonati 5 parts, Radix Ophiopogonis 4 parts, Herba Dendrobii 10 parts, Radix Puerariae 6 parts, the Cortex Eucommiae 5 parts, Fructus Corni 5 parts, Semen Euryales 8 parts, Fructus Schisandrae Chinensis 6 parts, Cortex Lycii 9 parts, Bulbus Fritillariae Cirrhosae 7 parts, Flos Lonicerae 5 parts, Rhizoma Curculiginis 7 parts, Radix Cynanchi Atrati 4 parts, 5 parts, Radix Rubiae, Semen Cassiae 3 parts, Fructus Chebulae 11 parts.
The preparation method of above-mentioned sugar-reduction traditional Chinese medicine composition, comprises the following steps:
Step 1, get Herb Gynostemmae Pentaphylli, Fructus Gardeniae, Rhizoma Dioscoreae, Rhizoma Polygonati Odorati, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, Folium Ginkgo, Herba Menthae, Leptoradix Ginseng, the Radix Astragali, Poria, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Alismatis, Fructus Hordei Germinatus, Radix Trichosanthis, Radix Rehmanniae, Rhizoma Polygonati, Radix Ophiopogonis, Herba Dendrobii, Radix Puerariae, the Cortex Eucommiae, Fructus Corni, Semen Euryales, Fructus Schisandrae Chinensis, Cortex Lycii, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Rhizoma Curculiginis, Radix Cynanchi Atrati, Radix Rubiae, Semen Cassiae and Fructus Chebulae, after mix homogeneously, be ground into coarse powder, carry out supercritical CO
2extraction, extracting pressure is 35MPa, and temperature is 40 DEG C, and extraction time is 4h.Collect extract;
Step 2, by step 1 gained extract after ultrafiltration membrance filter, the molecular cut off of ultrafilter membrane is 1200000Da, and concentrated, spraying dry, obtains Chinese medicine composition.
Test example 1 toxicity research is tested
Studies on acute toxicity:
Get Kunming mouse, give medicine of the present invention (compound for reducing blood suger prepared by embodiment 1 to 5) by 10g/kg gavage, 1 day successive administration 4 times, every minor tick 6h, then give normal diet, pathologic inspection is carried out to each organ, does not find organ disease.
Long term toxicity is studied:
Get Kunming mouse, in pressing, heavy dose of group of (4g/kg, 8g/kg) gavage gives medicine of the present invention (compound for reducing blood suger prepared by embodiment 1 to 5), every day 1 time, successive administration is after 14 days, measure the indexs such as Mouse Weight, cardiac function, liver function, renal function, electrocardiogram, administration group compares with matched group respectively, shows no obvious abnormalities.The internal organs such as the pathological examination heart, liver,kidney,spleen, lung, Stomach duodenum, large intestine, small intestinal, adrenal gland and genitals, administration group compares with matched group respectively, is showed no obvious toxic and changes.Above result points out Chinese medicine composition safety non-toxic of the present invention, can be used for clinical.
The test example 2 blood sugar lowering test of pesticide effectiveness
Laboratory animal: Kun Ming mice, 80, each 40 of male and female, healthy, body weight 18 ~ 22g.Get above-mentioned mice to divide at random 8 groups (blank group, model group, positive drug control group, test group) by body weight, often organize 10, each 5 of male and female, each treated animal is all drunk water under same environment, ingest, keep natural lighting (temperature 25 DEG C, humidity 60 ~ 70%).
Experimental drug:
Test group: the compound for reducing blood suger that any one of the embodiment of the present invention 1 to 5 obtains;
Positive drug control: glyburide, Beijing doube bridge pharmaceutical factory produces;
Model formulation: Glucose Oxidase kit, the safe clinical reagent company limited of Beijing Northization produces.
Experimental technique: before test, by administration after above-mentioned mice fasting 14h.The compound for reducing blood suger of the embodiment of the present invention 1 to 5 presses 50mg/Kg dosage gastric infusion respectively, and glyburide gavages by the dosage of 50mg/Kg.Except blank group, each group, after administration 30min, gavages 20% glucose solution by 0.2ml/Kg, and difference 30min, 90min upon administration, get blood from socket of the eye venous sinus, with determination of glucose oxidase blood glucose.Take blood sugar concentration as index, between each group of administration and model group, carry out t inspection.The results are shown in following table.
Compound for reducing blood suger reduces the effect of mouse blood sugar
Wherein, * P < 0.05, * * P < 0.01.
As can be known from the above table, compound for reducing blood suger provided by the invention effectively can reduce blood glucose, and hypoglycemic effect is far superior to existing medicine, can be widely used in the medicine of preparation treatment diabetes.Wherein, embodiment 6, compared with embodiment 3, by improving the concocting method of Radix Angelicae Sinensis, making its impurity can remove in concocting process, avoiding impurity impact on main constituent in macroporous absorption purge process, improve the hypoglycemic effect of pharmaceutical composition.
Claims (8)
1. a sugar-reduction traditional Chinese medicine composition, it is characterized in that: comprise with parts by weight: Herb Gynostemmae Pentaphylli 2 ~ 9 parts, Fructus Gardeniae 1 ~ 7 part, Rhizoma Dioscoreae 3 ~ 8 parts, Rhizoma Polygonati Odorati 1 ~ 5 part, Radix Polygoni Multiflori 2 ~ 8 parts, Fructus Lycii 1 ~ 7 part, Radix Angelicae Sinensis 2 ~ 9 parts, Folium Ginkgo 3 ~ 9 parts, Herba Menthae 1 ~ 8 part, Leptoradix Ginseng 2 ~ 7 parts, the Radix Astragali 1 ~ 6 part, 3 ~ 8 parts, Poria, the Rhizoma Anemarrhenae 4 ~ 12 parts, Radix Angelicae Sinensis 1 ~ 7 part, Rhizoma Chuanxiong 2 ~ 9 parts, Radix Salviae Miltiorrhizae 2 ~ 10 parts, Radix Paeoniae Rubra 1 ~ 8 part, Rhizoma Alismatis 2 ~ 9 parts, 4 ~ 10 parts, Fructus Hordei Germinatus, Radix Trichosanthis 2 ~ 8 parts, Radix Rehmanniae 1 ~ 7 part, Rhizoma Polygonati 3 ~ 8 parts, Radix Ophiopogonis 2 ~ 7 parts, Herba Dendrobii 4 ~ 12 parts, Radix Puerariae 3 ~ 9 parts, the Cortex Eucommiae 2 ~ 8 parts, Fructus Corni 3 ~ 7 parts, Semen Euryales 1 ~ 9 part, Fructus Schisandrae Chinensis 2 ~ 8 parts, Cortex Lycii 3 ~ 10 parts, Bulbus Fritillariae Cirrhosae 4 ~ 9 parts, Flos Lonicerae 1 ~ 6 part, Rhizoma Curculiginis 1 ~ 9 part, Radix Cynanchi Atrati 3 ~ 6 parts, 2 ~ 8 parts, Radix Rubiae, Semen Cassiae 1 ~ 9 part, Fructus Chebulae 4 ~ 12 parts.
2. the preparation method of sugar-reduction traditional Chinese medicine composition according to claim 1, is characterized in that: comprise the following steps:
Step 1, get Herb Gynostemmae Pentaphylli, Fructus Gardeniae, Rhizoma Dioscoreae, Rhizoma Polygonati Odorati, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, Folium Ginkgo, Herba Menthae, Leptoradix Ginseng, the Radix Astragali, Poria, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Alismatis, Fructus Hordei Germinatus, Radix Trichosanthis, Radix Rehmanniae, Rhizoma Polygonati, Radix Ophiopogonis, Herba Dendrobii, Radix Puerariae, the Cortex Eucommiae, Fructus Corni, Semen Euryales, Fructus Schisandrae Chinensis, Cortex Lycii, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Rhizoma Curculiginis, Radix Cynanchi Atrati, Radix Rubiae, Semen Cassiae and Fructus Chebulae, after mix homogeneously, be ground into coarse powder, carry out supercritical CO
2extraction, collects extract;
Step 2, adsorbs step 1 gained extract through macroporous adsorbent resin, then carries out eluting with ethanol water, obtain eluent;
Step 3, by step 2 gained eluent after ultrafiltration membrance filter, concentrated, dry, obtain Chinese medicine composition.
3. the preparation method of sugar-reduction traditional Chinese medicine composition according to claim 2, is characterized in that: supercritical CO in step 1
2the pressure of extraction is 20 ~ 45MPa, and temperature is 25 ~ 50 DEG C, and extraction time is 3 ~ 5h.
4. the preparation method of sugar-reduction traditional Chinese medicine composition according to claim 2, is characterized in that: macroporous adsorbent resin described in step 2 is selected from AB-8, NKA, HDP-100, HDP-722 or HDP-750.
5. the preparation method of sugar-reduction traditional Chinese medicine composition according to claim 2, is characterized in that: in step 2, the concentration of ethanol water is 60 ~ 90wt.%.
6. the preparation method of sugar-reduction traditional Chinese medicine composition according to claim 2, is characterized in that: the molecular cut off of ultrafilter membrane described in step 3 is 100000 ~ 200000Da.
7. the preparation method of sugar-reduction traditional Chinese medicine composition according to claim 2, is characterized in that: dry in step 3 is lyophilization or spraying dry.
8. the preparation method of sugar-reduction traditional Chinese medicine composition according to claim 2, is characterized in that: when the yellow wine system of being classified as, and concocts step to be: Radix Angelicae Sinensis adds yellow wine and mixes thoroughly, after vexed, and parch at 210 ~ 220 DEG C.
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Application publication date: 20150708 |