CN106109521A - A kind of Radix Notoginseng oral liquid - Google Patents
A kind of Radix Notoginseng oral liquid Download PDFInfo
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Abstract
The invention discloses a kind of Radix Notoginseng oral liquid, it includes Radix Notoginseng extract and straight chain activation of small molecule water；Product of the present invention, while quickly supplementing cell moisture, also can make effective ingredient rapid osmotic enter cell, through focus, be used for preventing and treat cardiovascular and cerebrovascular vessel relevant disease；Reduce blood lipid level, particularly triglyceride；Regulation blood glucose, improves hyperglycemia viscous pasty state, reduces complication；Expansion blood vessel, improves microcirculation, regulates blood pressure, maintains blood pressure balance；Enhancing human body immunity power, slow down aging, the health-care effect such as antitumor.
Description
Technical field
The invention belongs to medicine production technical field, be specifically related to one can quickly absorb, lowering blood pressure and blood fat, benefit
Gas, the Radix Notoginseng oral liquid of raising body immunity in benefit.
Background technology
Radix Notoginseng: have another name called Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), for Araliaceae, using its root as medicinal effects, has dissipating blood stasis hemostasis, and detumescence is fixed
Effect of pain.Cure mainly spitting of blood, spit blood, epistaxis, to have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling down swells and ache.Radix Notoginseng is the most medicinal
Composition has Radix Notoginseng total arasaponins, Radix Notoginseng flavone and Radix Notoginseng polysaccharide etc..Radix Notoginseng total arasaponins is by ginsenoside rg1, rb1, re and Radix Notoginseng soap
Glycosides r1 etc. is grouped into, and is Radix Notoginseng chief active position, and modern pharmacology finds, the pharmacologically active of Radix Notoginseng essentially consists in and improves blood
The aspects such as system and systema cariovasculare functional, strengthening by means of tonics, immunomodulating；Radix Notoginseng flavone have blood fat reducing, scavenging activated oxygen,
Suppression Platelet；And Radix Notoginseng polysaccharide is improved the effect of immunity of organisms.
Radix Angelicae Sinensis: Radix Angelicae Sinensis is mainly containing sucrose, several amino acids, volatile oil and n-butene, lactone, nicotinic acid, ferulic acid and half
Terpenoid, possibly together with VitAVitE, volatile oil, arginine and several mineral materials.Warm in nature, sweet in the mouth is pungent.GUIXIN,
Liver, spleen channel.Benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation.Controlling menoxenia, amenorrhea is suffered from abdominal pain, and lump in the abdomen knot is poly-, metrorrhagia；Blood deficiency head
Bitterly, dizziness, flaccidity syndrome and arthralgia syndrome；Dryness of the intestine dyschezia, weight after bloody dysentery；Carbuncle skin ulcer is stolen, injury from falling down.1. enrich blood, body hemopoietic merit can be remarkably promoted
Can, raise erythrocyte, leukocyte and content of hemoglobin；2. Adjust-blood lipid, suppresses platelet aggregation, antithrombotic, regulates blood fat；3.
Blood pressure lowering, resists myocardial ischemia, arrhythmia, expands blood vessel, reduces blood pressure；4. enhancing immunity, strengthen immunity, antiinflammatory, protect the liver,
Radioprotective, antioxidation and removing free radical etc..It addition, uterine smooth muscle can also be regulated.
Rhizoma Chuanxiong: Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong (Ligusticum chuanxiong).Treatment headache
Choice drug.Menoxenia；Amenorrhea dysmenorrhea；Puerperal the stasis of blood stagnant raw meat pain；Lump in the abdomen lump；Pain in chest and hypochondrium；Headache dizziness；Anemofrigid-damp arthralgia；
Traumatic injury；Ulcer sores etc..
Radix Codonopsis: for traditional tonic that China is conventional, ancient times are top grade with the Radix Codonopsis that area, Shangdang, Shanxi produces, and have benefit
Middle QI invigorating, effect of strengthening spleen and tonifying lung.Modern study, Radix Codonopsis contains various saccharides, phenols, sterol, volatile oil, baicalin glucose
Glycoside, Saponin and Alkaloid, have enhancing immunity, expansion blood vessel, blood pressure lowering, improve the work such as microcirculation, enhancing hemopoietic function
With.In addition the leukopenia caused chemotherapy radiotherapy has castering action.
The Radix Astragali: the Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, lack of appetite
Loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and bursts for a long time and does not holds back, and blood deficiency and yellow complexion, interior-heat is quenched one's thirst.
" herbal classic " is recorded: " main carbuncle loses skin ulcer, evacuation of pus pain relieving for a long time.Qi-restoratives, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas to strengthen muscle
Bone, puts on flesh and enriches blood.
Cortex Cinnamomi: Cortex Cinnamomi extremely hot in nature, acrid in the mouth, sweet.Cure mainly: insufficiency of kidney-YANG；Gate of vitality's fire aversion to cold and cold limbs；Soreness of the waist and knees；Sexual impotence is lost
Essence；Dysuria or frequency；Lose heart dyspnea with rapid and short breath；The all cards of edema oliguria；Decline of the fire from the gate of life；Fire not Gui Yuan；Floating YANG；Refusing yang；And under upper heat
Cold；Flushed complexion cold foot；Dizziness and tinnitus；Dispute gruel is broken；Spleen-kidney vacuity cold；Coldness and pain in the epigastrium；Decreased food intake loose stool；Lumbago due to renal deficiency；Arthralgia due to cold-dampnes；Cold
Hernia pain；Cold womb is infertile；Dysmenorrhea amenorrhea；Puerperal the stagnant stomachache of the stasis of blood；Carbuncle of yin nature multiple abscess；Or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus；Or do not hold back after bursting.
Radix Glycyrrhizae: Radix Glycyrrhizae property is put down, sweet in the mouth returns 12 warps.Have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer.
In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, to grow and cough lung moistening, emergency is detoxified, and is in harmonious proportion hundred medicines.Clinical practice divide " raw with " and " processed with honey " it
Not.Raw with curing mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.；Processed with honey cures mainly spleen and stomach function
Going down, big loose stool is thin, weak heating and cough, cardiopalmus etc..
Ampelopsis grossedentata: Ampelopsis grossedentata, Doanngo tea, rattan mother-in-law's tea (also known as mountain Folium hydrangeae strigosae, dragon beard tea).It is that Vitaceae Ampelopsis shows tooth
The young stem and leaf of Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) section (Ampelopsis grossedentata) (Hand-Mazz) W.T.wang.English name is vine
tea.Primary growth is in various places, China Chiang-Nan mountain area.This dark brown green bloom；The sweet length of micro-hardship, promoting the production of body fluid to quench thirst；Its sweet in the mouth sugariness is cool,
There is the effects such as heat-clearing and toxic substances removing, anti-inflammation, expelling wind and removing dampness, bone and muscle strengthening, lowering blood pressure and blood fat, hepatoprotective.Among the people it is usually used in
The preventing and treating of the diseases such as hypertension, cold, fever, cardiovascular and cerebrovascular disease, dermatitis, eczema.
Straight chain activation of small molecule water is to replicate with earth earth's magnetic field same frequency 7.8HZ, utilizes and is referred to as destructive interference
Physical resonant vibration effect, changes the hydrogen bond angle of micel structure and hydrone so that water clusters is spatially arranged in straight chain
Cloth, making hydrone molecular frequency is also 7.8HZ, makes the energy of water strengthen and is easier to integrate free radical.
The general water of ratio of viscosities of this low frequency water is low 400 times, this moisture or internal flowed in making blood vessel and blood capillary
The speed that cell absorbs increases by 3 times, reduces viscosity and means when the tiny pore in water penetration human body and blood capillary, its tool
There are fabulous mobility and extremely low resistance.People really can be made to want to drink to obtain water, be transformed into cell need water (cell is directly drunk
Water), after drinking 20 minutes, the viscosity of blood is i.e. improved, and blood rubbish is effectively cleared up.Formulated drink can also change
The quality of beverage and edible liquid, mouthfeel is more preferable.
Confirm that at present human body is the most different at different age level PCms, from embryo, baby, adult normal,
Old man's water content reduces successively, and percentage ratio is 100%, 80%, 70%, 50% respectively.Also confirm that dehydration can make in human body to produce simultaneously
The physiological environment being conducive to cancerous cell to be formed, produce multinomial physiological dysfunction (DNA is impaired, DNA repair system efficiency declines,
Receptor imbalance, immune system are suppressed), doctor of medicine's F battement of the U.S. also elaborates in " water is best medicine "
One world-shaking medical discovery, health hydropenia is the arch-criminal of chronic disease.So moisturizing and correct moisturizing are ours
Become the most important in the middle of life.
Summary of the invention
It is an object of the present invention to provide a kind of Radix Notoginseng oral liquid, it includes Radix Notoginseng extract and straight chain activation of small molecule water,
Wherein Radix Notoginseng extract mass percent concentration in straight chain activation of small molecule water is 2-10%.
Another object of the present invention is to provide a kind of composite oral liquid containing Radix Notoginseng extract, and it is that every 100mL straight chain is little
In molecule activation water containing Radix Notoginseng extract 2.5-4.5g, Radix Angelicae Sinensis extract 0.5-1.25g, Rhizoma Chuanxiong extract 0.25-0.38g,
Radix Astragali extract 0.5-1.05g, Radix Codonopsis extract 0.2-0.6g, Cortex Cinnamomi extract 0.05-0.15g, Radix Glycyrrhizae extract 0.15-
0.45g, Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract 0.8-2.0g.
The preparation method of above-mentioned Radix Notoginseng extract is as follows:
(1) Yunnan mountain of papers Radix Notoginseng tuberous root is pulverized, cross 60 mesh sieves standby；
(2) in the ratio that mass volume ratio g:mL is 1:10-12 of Radix Notoginseng powder Yu water, with the water soaking Radix Notoginseng of temperature 30-50 DEG C
After powder 30-60 minute, supersound process 10-20 minute；
(3) temperature of set-up procedure (2) soak is 40-50 DEG C, adds pectase, α-amylase and cellulase, stirs enzyme
Solve 20-30 minute；Chilling temperature, to 30-40 DEG C, adds the flocculant of coolant quality 0.5 ‰-2 ‰, flocculant while stirring
After being completely dissolved, standing 30-50 minute, filter, wherein the addition of pectase is the 0.2-0.5% of soak quality, alphalise starch
The addition of enzyme is the 0.5-0.9% of soak quality, and the addition of cellulase is the 0.1-0.4% of soak quality；
(4) filtrate of step (3) is crossed nonpolarity macroporous adsorptive resins chromatographic column, be 5-8%, 30-with concentration of volume percent successively
35%, the ethanol solution of 70-80% carries out gradient elution, collects eluent, respectively obtains containing Radix Notoginseng polysaccharide, Radix Notoginseng flavone and three
The solution of seven saponin；Concentration and recovery ethanol after the eluent mix homogeneously that will collect, is then passed through weak basic anion exchange tree
Fat post, collects effluent, and concentrate drying i.e. obtains Radix Notoginseng extract.
Described ultrasonic power is 150-250w.
In the present invention, weak basic anion exchange model is D001 etc..
Nonpolar macroporous adsorption resin model is D401, D402 etc..
Radix Notoginseng oral liquid of the present invention can also add in prepared by traditional oral liquid the adjuvant added by dosage routinely, in order to
Oral liquid for adjusting mouthfeel, stability etc., such as sweet taste correctives, above-mentioned oral liquid prepared after sterilizing according to a conventional method, point
Fill and i.e. obtain Radix Notoginseng oral liquid finished product.
Described straight chain activation of small molecule water prepares, for example with Zhong Ke nation of Shenzhen for using Conventional activation water preparation apparatus
Reach company limited's equipment Schumann ripple low frequency water-activating instrument (MR-605) to obtain.
In the present invention, Radix Angelicae Sinensis extract, Rhizoma Chuanxiong extract, Radix Astragali extract, Radix Codonopsis extract, Cortex Cinnamomi extract, Radix Glycyrrhizae carry
Take thing, Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract is conventional commercial product or according to a conventional method prepare extract, extracting method can use
But it is not limited to following methods:
Radix Angelicae Sinensis extract technique is as follows: angelica root is selected to be smashed, and crosses 20 mesh sieves standby；By the ratio that solid-liquid ratio g:mL is 1:12-15
Example, the ethanol solution adding concentration of volume percent 50-70% in Radix Angelicae Sinensis powder carries out circumfluence distillation, during each reflux, extract,
Between 40-60 minute, extract 2-3 time；Collect extracting solution, filter and go the removal of impurity, concentrate, be spray-dried and i.e. obtain Radix Angelicae Sinensis extract.
Rhizoma Chuanxiong extract technique is as follows: selected Rhizoma Chuanxiong dry rhizome, smashes 20 mesh sieves standby；It is 1 by solid-liquid ratio g:mL:
The ratio of 10-12, the ethanol solution adding concentration of volume percent 70-80% in Rhizoma Chuanxiong power carries out circumfluence distillation, returns every time
40-50 minute extraction time of stream, extract 2-3 time；Collect extracting solution, filter and go the removal of impurity, concentrate, be spray-dried and i.e. obtain Radix Angelicae Sinensis and carry
Take thing.
Radix Astragali extract technique is as follows: selected astragalus root, smashes 20 mesh sieves；In the ratio of solid-liquid ratio g:mL 1:8-10,
In astragalus membranaceus powder, add water carry out decocting extraction, 60-80 minute each extraction time, extraction time 2-3 time；Collect extracting solution,
It is concentrated to ointment density 1.1-1.25；Adding the ethanol of concentration of volume percent 95%, stirring and adjusting is to the ethanol of extractum diluent
Concentration reaches 50-60%, stands precipitate with ethanol 30-40 minute；Collect precipitate with ethanol supernatant concentration, be spray-dried and obtain Radix Astragali extract.
Radix Codonopsis extract's technique is as follows: selected Radix Codonopsis root, smashes 20 mesh sieves；In the ratio of solid-liquid ratio g:mL 1:9-11,
In Radix Codonopsis powder, add water carry out decocting extraction, 55-70 minute extraction time, extraction time 2-3 time；Collect extracting solution, concentrate
To ointment density 1.1-1.25；Adding the ethanol of concentration of volume percent 95%, stirring and adjusting is to the concentration of alcohol of extractum diluent
Reach 50-60%, stand precipitate with ethanol 30-40 minute；Collect precipitate with ethanol supernatant concentration, be spray-dried and obtain Radix Codonopsis extract.
Cortex Cinnamomi extract technique is as follows: selected Cortex Cinnamomi, smashes 20 mesh sieves；In the ratio of solid-liquid ratio g:mL 1:6-8,
Raw material adds water carry out decocting extraction, 40-55 minute extraction time, extraction time 2-3 time；Collect extracting solution, be concentrated to medicine
Cream density 1.1-1.25；Adding the ethanol of concentration of volume percent 95%, stirring and adjusting reaches to the concentration of alcohol of extractum diluent
60-70%, stands precipitate with ethanol 30-40 minute；Collect precipitate with ethanol supernatant to continue to concentrate, be concentrated to give paste Cortex Cinnamomi extract.
Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract extraction process is as follows: selected Ampelopsis grossedentata, by the ratio of solid-liquid ratio g:mL1:15-18
Example, adds purification water boiling and extraction, 50-60 minute extraction time, extracts 2 times；Collect extracting solution, be concentrated to ointment density 1.1-
1.25, add the ethanol of concentration of volume percent 95%, the concentration of alcohol of stirring and adjusting to extractum diluent reaches 45-50%, quiet
Put precipitate with ethanol 40-55 minute；Collecting precipitate with ethanol supernatant concentration, concentrated spray is dried to obtain Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract.
Radix Glycyrrhizae extract technique is as follows: essence chooses dry licorice, smashes 20 mesh sieves standby；By solid-liquid ratio g:mL 1:7-
The ratio of 10, adds weak ammonia alcoholic solution in the feed, and wherein constituent and the percentage ratio of weak ammonia alcoholic solution is ammonia volume
Percentage ratio is 0.4-0.7%, ethanol percent by volume is 60%, remaining is water；Maintain temperature 35-45 DEG C, stirring to extract 60-80 to divide
Clock, extracts 2 times, collects supernatant, concentrates, be spray-dried and i.e. obtain Radix Glycyrrhizae extract.
The present invention compared with prior art has the advantage that 1, the single extraction process of Radix Notoginseng the most prevailing is had
Effect combination, lifting effective ingredient retention and extraction ratio, application combination macroporous adsorbent resin and ion exchange resin simultaneously,
Gradient elution principle active component, removes the pesticide brought because of Chinese medicine plant simultaneously and endangers with heavy-metal residual；2, it is molten with water
It is basic ideas that agent globality extracts the effective site (active materials) of Chinese medicine, maintains advantage and the characteristic of Chinese medicine；3、
Not through the process such as high temperature, organic solvent extraction during extraction, use physical method effectively to extract ingredient, remain
The integrity of ingredient；4, in the allotment of Radix Notoginseng oral liquid, straight chain activation of small molecule water is used, hence it is evident that improve ingredient
Dissolution rate and the stability of finished product, moreover it is possible to make effective ingredient rapidly enter human body cell, repair impaired, active cell merit
Energy.
Inventive formulation is theoretical according to the compatibility of drugs of monarch, and Radix Notoginseng is monarch drug, promoting flow of QI and blood, blood-activating analgetic, when
Returning with Rhizoma Chuanxiong is ministerial drug, replenishing and activating blood, dissipating blood stasis cold expelling；The Radix Astragali, Radix Codonopsis and Cortex Cinnamomi are adjuvant drug invigorating middle warmer yang invigorating, temperature three-way meridian；Radix Glycyrrhizae
For making medicine, coordinating the actions of various ingredients in a prescription, inducting the medicines into affected channel.Open impatency, blood-activating and qi-promoting, invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid, tonifying Qi and lifting yang, thus reach
To promoting blood circulation to remove obstruction in the collateral, regulation blood fat and blood pressure effect；It is equipped with new resource food Ampelopsis grossedentata, expelling wind and removing dampness, strong muscle simultaneously
Bone, promoting the production of body fluid to quench thirst, hepatoprotective.
Product of the present invention, while quickly supplementing cell moisture, also can make effective ingredient rapid osmotic enter thin
Born of the same parents, through focus, it is used for preventing and treat cardiovascular and cerebrovascular vessel relevant disease；Reduce blood lipid level, particularly triglyceride；Regulation blood
Sugar, improves hyperglycemia viscous pasty state, reduces complication；Expansion blood vessel, improves microcirculation, regulates blood pressure, maintains blood pressure balance；Increase
Strong immunity of organisms, slow down aging, antitumor action；And preparation is simple, production suitable for industrialized and marketing application.
Detailed description of the invention
Below by embodiment, the present invention is described in further detail, but scope is not limited to described interior
Hold.
Embodiment 1: this Radix Notoginseng oral liquid includes Radix Notoginseng extract and straight chain activation of small molecule water, wherein Radix Notoginseng extract
Mass percent concentration in straight chain activation of small molecule water is 2.5%；Radix Notoginseng oral liquor is as follows:
(1) the Yunnan mountain of papers genuine Radix Notoginseng tuberous root of selected 60 is smashed, cross 60 mesh sieves standby；
(2) in the ratio that mass volume ratio g:mL is 1:10 of Radix Notoginseng powder Yu water, with the water soaking Radix Notoginseng powder 40 points of temperature 40 DEG C
Clock, and then 150w ultrasonic Treatment 10 minutes；
(3) temperature of set-up procedure (2) soak 40 DEG C, adds pectase, α-amylase and cellulose esterase, continuously stirred enzyme
Solve 20 minutes；Chilling temperature to 30 DEG C, adds the flocculant (gelatin) of coolant quality 1.0 ‰ while stirring, and flocculant is complete
Keeping after dissolving standing, time of repose 40 minutes, filter, make solid-liquid separation, wherein the addition of pectase is soak quality
0.2%, the addition of α-amylase is the 0.5% of soak quality, and the addition of cellulase is the 0.1% of soak quality；
(4) filtrate of step (3) is crossed nonpolar macroporous adsorption resin (D401) post, with concentration of volume percent be successively
5%, the ethanol solution of 31%, 70% carries out gradient elution, collects eluent, respectively obtains containing Radix Notoginseng polysaccharide, Radix Notoginseng flavone and three
The solution of seven saponin；Concentration and recovery ethanol after the eluent mix homogeneously that will collect, is then passed through weak basic anion exchange tree
Fat (D001) post, collects effluent, and concentrate drying i.e. obtains Radix Notoginseng extract；Through data analysis, this extracts Radix Notoginseng total arasaponins
Content reaches 39.73%；
(5) adding in straight chain activation of small molecule water by step (4) Radix Notoginseng extract, to final concentration of 2.5%, low temperature (4 DEG C) is cold
Freeze standing 10 hours, then 0.2 μm membrane filtration；Filtrate carries out fill, rolls lid, moist heat sterilization 5 minutes, obtains brownish red three
Seven oral liquid finished products.
Using voluntary principle, recruit hyperpietic and carry out foretasting experiment, this group recruits 30 people, and half is experimental group
(taking above-mentioned oral liquid), half is matched group (taking conventional buck Western medicine reserpine), within 2 weeks, is a course for the treatment of, collects one
Data blood pressure data before the course for the treatment of and after the course for the treatment of, carries out statistical analysis more afterwards, and result shows P ＜ 0.05, and difference has
Statistically significant.After treatment, experimental group and matched group show at the comparative result of these two indexs, and P ＜ 0.05, difference has
Statistical significance.
<120/80mmHg,>=140/90mmHg are hypertension to human normal pressure value；
Table 1: blood pressure synopsis before and after experiment
。
Embodiment 2: this Radix Notoginseng oral liquid includes Radix Notoginseng extract and straight chain activation of small molecule water, wherein Radix Notoginseng extract
Mass percent concentration in straight chain activation of small molecule water is 8%；Radix Notoginseng oral liquor is as follows:
(1) the Yunnan mountain of papers genuine Radix Notoginseng tuberous root of selected 60 is smashed, cross 60 mesh sieves standby；
(2) in the ratio that mass volume ratio g:mL is 1:12 of Radix Notoginseng powder Yu water, with the water soaking Radix Notoginseng powder 60 points of temperature 30 DEG C
Clock, and then 200w ultrasonic Treatment 15 minutes；
(3) temperature 50 C of set-up procedure (2) soak, adds pectase, α-amylase and cellulose esterase, continuously stirred enzyme
Solve 25 minutes；Chilling temperature to 40 DEG C, adds the flocculant (chitin) of coolant quality 0.5 ‰ while stirring, and flocculant is complete
Keeping after CL standing, time of repose 50 minutes, filter, make solid-liquid separation, wherein the addition of pectase is soak matter
The 0.4% of amount, the addition of α-amylase is the 0.7% of soak quality, and the addition of cellulase is soak quality
0.2%；
(4) filtrate of step (3) is crossed nonpolar macroporous adsorption resin (D402) post, with concentration of volume percent be successively
8%, the ethanol solution of 35%, 80% carries out gradient elution, collects eluent, respectively obtains containing Radix Notoginseng polysaccharide, Radix Notoginseng flavone and three
The solution of seven saponin；Concentration and recovery ethanol after the eluent mix homogeneously that will collect, is then passed through weak basic anion exchange tree
Fat (D001) post, collects effluent, and concentrate drying i.e. obtains Radix Notoginseng extract；Through data analysis, this extracts Radix Notoginseng total arasaponins
Content reaches 39.96%；
(5) adding in straight chain activation of small molecule water by step (4) Radix Notoginseng extract, to final concentration of 8%, low temperature (4 DEG C) is freezing
Stand 10 hours, then 0.2 μm membrane filtration；Filtrate carries out fill, rolls lid, moist heat sterilization 5 minutes, obtains brownish red Radix Notoginseng
Oral liquid finished product.
Using voluntary principle, recruit hyperpietic and carry out foretasting experiment, this group recruits 30 people, and half is experimental group
(taking above-mentioned oral liquid), half is matched group (taking conventional buck Western medicine metoprolol), within 2 weeks, is a course for the treatment of, collects one
Blood pressure data before the individual course for the treatment of and after the course for the treatment of, carries out statistical analysis more afterwards, and result shows P ＜ 0.05, and difference has
Statistical significance.After treatment, experimental group and matched group show at the comparative result of these two indexs, and P ＜ 0.05, difference has system
Meaning learned by meter.
<120/80mmHg,>=140/90mmHg are hypertension to human normal pressure value
Blood pressure synopsis before and after table 2 experiment
。
Embodiment 3: this Radix Notoginseng oral liquid is containing Radix Notoginseng extract 3g, Radix Angelicae Sinensis in every 100mL straight chain activation of small molecule water
Extract 0.5g, Rhizoma Chuanxiong extract 0.25g, Radix Astragali extract 0.5g, Radix Codonopsis extract 0.4g, Cortex Cinnamomi extract 0.1g, Radix Glycyrrhizae
Extract 0.15g, Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract 1g.
The preparation method of above-mentioned Radix Notoginseng oral liquid is as follows:
(1) Yunnan mountain of papers Radix Notoginseng tuberous root is pulverized, cross 60 mesh sieves standby；
(2) in the ratio that mass volume ratio g:mL is 1:11 of Radix Notoginseng powder Yu water, with the water soaking Radix Notoginseng powder 60 points of temperature 50 C
Zhong Hou, 250w supersound process 15 minutes；
(3) temperature of set-up procedure (2) soak is 45 DEG C, adds pectase, α-amylase and cellulase, stirs enzymolysis 30
Minute；Chilling temperature, to 35 DEG C, adds the flocculant (tannin) of coolant quality 2 ‰ while stirring, after flocculant is completely dissolved,
Standing 40 minutes, filter, wherein the addition of pectase is the 0.5% of soak quality, and the addition of α-amylase is soak
The 0.9% of quality, the addition of cellulase is the 0.1% of soak quality；
(4) filtrate of step (3) is crossed nonpolarity macroporous adsorptive resins chromatographic column (D402), with concentration of volume percent be successively
7%, the ethanol solution of 33%, 75% carries out gradient elution, collects eluent, respectively obtains containing Radix Notoginseng polysaccharide, Radix Notoginseng flavone and three
The solution of seven saponin；Concentration and recovery ethanol after the eluent mix homogeneously that will collect, is then passed through weak basic anion exchange tree
Fat post (D001), collects effluent, and concentrate drying i.e. obtains Radix Notoginseng extract.This content extracting Radix Notoginseng total arasaponins reaches
39.88%。
(5) Radix Notoginseng extract, Radix Angelicae Sinensis extract, Rhizoma Chuanxiong extract, Radix Astragali extract, Radix Codonopsis extract, Cortex Cinnamomi are extracted
Thing, Radix Glycyrrhizae extract, Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract mix, with straight chain activation of small molecule water as solvent；Add conventional sweet taste to rectify
Taste agent, after stirring and dissolving, low temperature (4 DEG C) is freezing stands 10 hours, then 0.2 μm membrane filtration；Filtrate carries out fill, rolls lid,
Moist heat sterilization 5 minutes, obtains brownish red Radix Notoginseng oral liquid finished product.
Using voluntary principle, recruit hyperpietic and carry out foretasting experiment, this group recruits 30 people, and half is experimental group,
Half is matched group (taking conventional buck Western medicine Nitrendipine Tablet), within 2 weeks, is a course for the treatment of, collects before a course for the treatment of and a treatment
Blood pressure data after journey, carries out statistical analysis more afterwards, and result shows P ＜ 0.05, and difference has statistical significance.Treatment
After, experimental group and matched group show at the comparative result of these two indexs, and P ＜ 0.05, difference has statistical significance.
<120/80mmHg,>=140/90mmHg are hypertension to human normal pressure value；
Table 3: blood pressure synopsis before and after experiment
Experimental group takes this Radix Notoginseng oral liquid after three months continuously, and blood pressure recovers normal.Withdrawing 2 weeks, blood pressure is the most normal.
Embodiment 4: this Radix Notoginseng oral liquid be in every 100mL straight chain activation of small molecule water containing Radix Notoginseng extract 2.5g, when
Return extract 1.25g, Rhizoma Chuanxiong extract 0.38g, Radix Astragali extract 1g, Radix Codonopsis extract 0.6g, Cortex Cinnamomi extract 0.07g, sweet
Grass extract 0.3g, Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract 2g.
The preparation method of above-mentioned Radix Notoginseng oral liquid is as follows:
(1) Yunnan mountain of papers Radix Notoginseng tuberous root is pulverized, cross 60 mesh sieves standby；
(2) in the ratio that mass volume ratio g:mL is 1:10 of Radix Notoginseng powder Yu water, with the water soaking Radix Notoginseng powder 60 points of temperature 30 DEG C
Zhong Hou, 150w supersound process 20 minutes；
(3) temperature of set-up procedure (2) soak is 50 DEG C, adds pectase, α-amylase and cellulase, stirs enzymolysis 20
Minute；Chilling temperature, to 30 DEG C, adds the flocculant (tannin) of coolant quality 0.8 ‰ while stirring, and flocculant is completely dissolved
After, stand 35 minutes, filter, wherein the addition of pectase is the 0.2% of soak quality, and the addition of α-amylase is leaching
The 0.5% of bubble liquid quality, the addition of cellulase is the 0.4% of soak quality；
(4) filtrate of step (3) is crossed nonpolarity macroporous adsorptive resins chromatographic column (D402), with concentration of volume percent be successively
6%, the ethanol solution of 30%, 80% carries out gradient elution, collects eluent, respectively obtains containing Radix Notoginseng polysaccharide, Radix Notoginseng flavone and three
The solution of seven saponin；Concentration and recovery ethanol after the eluent mix homogeneously that will collect, is then passed through weak basic anion exchange tree
Fat post (D001), collects effluent, and concentrate drying i.e. obtains Radix Notoginseng extract.This content extracting Radix Notoginseng total arasaponins reaches
39.81%。
(5) Radix Notoginseng extract, Radix Angelicae Sinensis extract, Rhizoma Chuanxiong extract, Radix Astragali extract, Radix Codonopsis extract, Cortex Cinnamomi are extracted
Thing, Radix Glycyrrhizae extract, Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract mix, with straight chain activation of small molecule water as solvent；Add conventional sweet taste to rectify
Taste agent, after stirring and dissolving, low temperature (4 DEG C) is freezing stands 10 hours, then 0.2 μm membrane filtration；Filtrate carries out fill, rolls lid,
Moist heat sterilization 5 minutes, obtains brownish red Radix Notoginseng oral liquid finished product.
Using voluntary principle, recruit hyperlipemic patients and carry out foretasting experiment, this group recruits 20 people, and half is experimental group,
Half is matched group, within 30 days, is a course for the treatment of, the blood fat data before collecting a course for the treatment of and after the course for the treatment of, unites more afterwards
Meter credit analysis, result shows P ＜ 0.05, and difference has statistical significance.After treatment, experimental group and blank group are at these two
The comparative result of index shows, P ＜ 0.05, difference has statistical significance.
T-CHOL (TC): normal range is at 5.23-5.69 mM/l；Triglyceride (TG): normal range
At 0.56-1.7 mM/l；Low density lipoprotein, LDL (LDL): scope is less than 3.12 mM/ls；
Table 4: blood fat synopsis before and after experiment
。
Embodiment 5: this Radix Notoginseng oral liquid be in every 100mL straight chain activation of small molecule water containing Radix Notoginseng extract 4.5g, when
Return extract 1g, Rhizoma Chuanxiong extract 0.3g, Radix Astragali extract 0.8g, Radix Codonopsis extract 0.4g, Cortex Cinnamomi extract 0.15g, Radix Glycyrrhizae
Extract 0.45g, Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract 0.8g.
The preparation method of above-mentioned Radix Notoginseng oral liquid is as follows:
(1) Yunnan mountain of papers Radix Notoginseng tuberous root is pulverized, cross 60 mesh sieves standby；
(2) in the ratio that mass volume ratio g:mL is 1:10 of Radix Notoginseng powder Yu water, with the water soaking Radix Notoginseng powder 60 points of temperature 30 DEG C
Zhong Hou, 150w supersound process 20 minutes；
(3) temperature of set-up procedure (2) soak is 50 DEG C, adds pectase, α-amylase and cellulase, stirs enzymolysis 20
Minute；Chilling temperature, to 30 DEG C, adds the flocculant (tannin) of coolant quality 0.8 ‰ while stirring, and flocculant is completely dissolved
After, stand 35 minutes, filter, wherein the addition of pectase is the 0.3% of soak quality, and the addition of α-amylase is leaching
The 0.7% of bubble liquid quality, the addition of cellulase is the 0.3% of soak quality；
(4) filtrate of step (3) is crossed nonpolarity macroporous adsorptive resins chromatographic column (D402), with concentration of volume percent be successively
6%, the ethanol solution of 30%, 80% carries out gradient elution, collects eluent, respectively obtains containing Radix Notoginseng polysaccharide, Radix Notoginseng flavone and three
Seven saponin；Concentration and recovery ethanol after the filter liquor mix homogeneously that will collect, is then passed through weak basic anion exchange post
(D001), collecting effluent, concentrate drying i.e. obtains Radix Notoginseng extract.This content extracting Radix Notoginseng total arasaponins reaches 39.75%.
(5) Radix Notoginseng extract, Radix Angelicae Sinensis extract, Rhizoma Chuanxiong extract, Radix Astragali extract, Radix Codonopsis extract, Cortex Cinnamomi are extracted
Thing, Radix Glycyrrhizae extract, Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract mix, with straight chain activation of small molecule water as solvent；Add conventional sweet taste to rectify
Taste agent, after stirring and dissolving, low temperature (4 DEG C) is freezing stands 10 hours, then 0.2 μm membrane filtration；Filtrate carries out fill, rolls lid,
Moist heat sterilization 5 minutes, obtains brownish red Radix Notoginseng oral liquid finished product.
Using voluntary principle, recruit hyperlipemic patients and carry out foretasting experiment, this group recruits 20 people, and half is experimental group,
Half is blank group, within 30 days, is a course for the treatment of, the blood fat data before collecting a course for the treatment of and after the course for the treatment of, the most laggard
Row statistical analysis, result shows P ＜ 0.05, and difference has statistical significance；After treatment, experimental group and blank group are at this
The comparative result of two indexs shows, P ＜ 0.05, difference has statistical significance.Monitoring blood fat related data (table five) shows,
Radix Notoginseng oral liquid has good lipid-lowering effect, and the decline of relevant blood lipids index all occurs in user, blood no longer thickness, blood vessel
Stopping state alleviates, and physical function reaches to be substantially improved.
T-CHOL (TC): normal range at 5.23-5.69 mM/l, triglyceride (TG): normal range
At 0.56-1.7 mM/l, low density lipoprotein, LDL (LDL): scope is less than 3.12 mM/ls；
Table 5: blood fat synopsis before and after experiment
。
Claims (5)
1. a Radix Notoginseng oral liquid, it is characterised in that including Radix Notoginseng extract and straight chain activation of small molecule water, wherein Radix Notoginseng carries
Taking thing mass percent concentration in straight chain activation of small molecule water is 2-10%.
Radix Notoginseng oral liquid the most according to claim 1, it is characterised in that contain in every 100mL straight chain activation of small molecule water
Radix Notoginseng extract 2.5-4.5g, Radix Angelicae Sinensis extract 0.5-1.25g, Rhizoma Chuanxiong extract 0.25-0.38g, Radix Astragali extract 0.5-
1.05g, Radix Codonopsis extract 0.2-0.6g, Cortex Cinnamomi extract 0.05-0.15g, Radix Glycyrrhizae extract 0.15-0.45g, Ampelopsis grossedentata
Extract 0.8-2.0g.
Radix Notoginseng oral liquid the most according to claim 1 and 2, it is characterised in that the preparation method of Radix Notoginseng extract is as follows:
(1) Yunnan mountain of papers Radix Notoginseng tuberous root is pulverized, cross 60 mesh sieves standby；
(2) in the ratio that mass volume ratio g:mL is 1:10-12 of Radix Notoginseng powder Yu water, with the water soaking Radix Notoginseng of temperature 30-50 DEG C
After powder 30-60 minute, supersound process 10-20 minute；
(3) temperature of set-up procedure (2) soak is 40-50 DEG C, adds pectase, α-amylase and cellulase, stirs enzyme
Solve 20-30 minute；Chilling temperature, to 30-40 DEG C, adds the flocculant of coolant quality 0.5 ‰-2 ‰, flocculant while stirring
After being completely dissolved, standing 30-50 minute, filter, wherein the addition of pectase is the 0.2-0.5% of soak quality, alphalise starch
The addition of enzyme is the 0.5-0.9% of soak quality, and the addition of cellulase is the 0.1-0.4% of soak quality；
(4) filtrate of step (3) is crossed nonpolarity macroporous adsorptive resins chromatographic column, be 5-8%, 30-with concentration of volume percent successively
35%, the ethanol solution of 70-80% carries out gradient elution, collects eluent, respectively obtains containing Radix Notoginseng polysaccharide, Radix Notoginseng flavone and three
The solution of seven saponin；Concentration and recovery ethanol after the eluent mix homogeneously that will collect, is then passed through weak basic anion exchange tree
Fat post, collects effluent, and concentrate drying i.e. obtains Radix Notoginseng extract.
Radix Notoginseng oral liquid the most according to claim 3, it is characterised in that ultrasonic power is 150-250w.
Radix Notoginseng oral liquid the most according to claim 3, it is characterised in that flocculant is gelatin, chitin or tannin.
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| CN108721353A (en) * | 2018-08-15 | 2018-11-02 | 云南龙发制药股份有限公司 | A kind of preparation method of Radix Notoginseng oral solution |
| CN114344352A (en) * | 2021-12-29 | 2022-04-15 | 汤臣倍健股份有限公司 | Composition with effect of resisting advanced glycosylation end products and application thereof |
| CN115006585A (en) * | 2022-06-01 | 2022-09-06 | 楼天女 | Wound dressing with good hemostatic performance and preparation method thereof |
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| CN108721353A (en) * | 2018-08-15 | 2018-11-02 | 云南龙发制药股份有限公司 | A kind of preparation method of Radix Notoginseng oral solution |
| CN114344352A (en) * | 2021-12-29 | 2022-04-15 | 汤臣倍健股份有限公司 | Composition with effect of resisting advanced glycosylation end products and application thereof |
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| CN115006585A (en) * | 2022-06-01 | 2022-09-06 | 楼天女 | Wound dressing with good hemostatic performance and preparation method thereof |
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