CN112402569A

CN112402569A - Anti-fatigue health product and preparation method thereof

Info

Publication number: CN112402569A
Application number: CN202011326832.4A
Authority: CN
Inventors: 胡剑; 林云鹏
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-11-24
Filing date: 2020-11-24
Publication date: 2021-02-26
Also published as: CN113018398A

Abstract

The invention discloses an anti-fatigue health product and a preparation method thereof, wherein the anti-fatigue health product comprises the following raw materials: the preparation method of the anti-fatigue health-care product comprises the following steps of: selecting and cleaning materials, pretreating the raw materials, decocting the raw materials for the first time, filtering to obtain a first liquid medicine, decocting for 1-2 times, mixing the liquid medicines, decocting, filtering, concentrating to obtain a fluid extract, adding proper maltose or honey, and decocting to obtain a finished product. The anti-fatigue health product and the preparation method thereof are prepared based on the guidance of the theory of traditional Chinese medicine, the main components are selected from medicinal and edible medicinal materials, the anti-fatigue health product has no toxic or side effect, is wide in applicable population, quick in effect, good in effect, simple to prepare, has good treatment and relief effects on fatigue caused by various factors, has the effects of strengthening the body resistance and consolidating the constitution, and is mild in medicine property and suitable for long-term administration.

Description

Anti-fatigue health product and preparation method thereof

Technical Field

The invention relates to the technical field of anti-fatigue health care products, in particular to an anti-fatigue health care product and a preparation method thereof.

Background

The fatigue in a broad sense includes physical fatigue, mental fatigue, psychological fatigue and mixed type fatigue. Traditional Chinese medicine has related records about fatigue in ancient books such as Huangdi's classic and plain questions, plain questions and pain-relieving treatises, and Jinkui jade function, the slightly edited and revised treatises, wherein fatigue is mainly attributed to liver function dominance and fatigue loss of primordial qi. The mechanism of fatigue generation is quite complex, and recent modern related researches suggest that the causes of fatigue are mainly attributed to the following three factors: 1. consumption of energy materials; 2. a large accumulation of metabolites; 3. changes in the environment in and out of the body, endocrine disorders, blood glucose lowering, ATP reduction, etc., which cause failure of the impulse of the central nervous system to generate or maintain the impulse to the muscles enough to meet the exercise needs, are the main causes of muscle fatigue during work.

The results of the World Health Organization (WHO) survey show that the global population is only 5% healthy, 20% sick, and 75% of the vast majority of the population is sub-healthy between healthy and sick. According to survey, the subhealth population in China accounts for about 60-70% of the total population. Through related researches, fatigue is one of the most common symptoms in sub-health, accounts for more than 40% of sub-health people, and is one of the causes most influencing the life quality of the sub-health people. According to the investigation of the world health organization, more than 35% of people worldwide are in fatigue state, especially 60% -75% of middle-aged male people in fatigue state. Along with social development, fatigue has become an increasingly non-negligible problem commonly possessed by modern people, and related medical researches show that long-term fatigue can cause feelings of boredom and conflict of people for work and study, interpersonal relation disorder and simultaneous accompanying multiple systemic symptoms, such as headache, dizziness, pharyngalgia, muscle and joint pain, anorexia, nausea, night sweat and the like, and the symptoms of difficult falling asleep, frequent waking in sleep, daytime sleepiness and the like are frequently presented. Along with the concern of people on fatigue, huge anti-fatigue health care products are in need of oil.

At present, the anti-fatigue health care products on the market are roughly divided into three types, wherein the two types are mainly used.

The first category is various functional beverages, and the main function of the functional beverages is sports fatigue resistance. In 1982, the definition of exercise-induced fatigue was unified in the fifth international exercise biochemical conference, and the exercise-induced fatigue was considered as follows: "the physiological process of the body cannot continue its function at a certain level or and the organs cannot maintain a predetermined exercise intensity.

Taking a functional beverage as an example, the formula composition of the functional beverage taking a can as a unit is as follows:

125mg of taurine, 50mg of lysine, 50mg of caffeine, 50mg of inositol, 61 mg of vitamin B, 123-123 ug of vitamin B and 10mg of nicotinamide.

125mg of taurine, 50mg of lysine, 50mg of inositol, 50mg of caffeine, 10mg of vitamin PP, 61 mg of vitamin B and 123 ug of vitamin B.

The two formulas are summarized to obtain the formula; the common components of the two are taurine, lysine, caffeine and vitamin. The function of resisting sports fatigue is mainly realized through the following mechanisms;

1. taurine

Taurine is essential amino acid for human body condition, has the main biological effects of maintaining the stability of membrane structure and regulating osmotic balance, has the function of preventing lipid peroxidation of cell membrane, and is an important cell protective agent. The most closely related expression of increased free radical production during exercise and reduced exercise capacity is that free radicals cause lipid peroxidation in biological membranes of various organs in vivo. Taurine as sports nutritional supplement can directly exert its effectThe antioxidant function can also enhance the antioxidant capacity of the organism by improving the activity of an antioxidant enzyme system in vivo, protect cell membranes from being attacked by free radicals and further enhance the movement capacity of the organism. Taurine can effectively regulate Ca caused by various reasons²⁺Dyshomeostasis, a good endogenous Ca²⁺A stabilizing regulator. Lipid peroxidation and Ca occurring in exercise-induced fatigue²⁺There is a close relationship between homeostatic disorders, disorders of energy metabolism and biofilm damage, and taurine has a good effect on all of these processes.

2. Caffeine

Caffeine acts on adenosine receptors to delay fatigue, which may be manifested in particular by increased lipolysis of caffeine, reduced glycogen to delay fatigue, by regulation of Ca²⁺Concentration increases muscle contractile potency, delays fatigue by reducing the perception of effort. Meanwhile, caffeine can promote adrenalin in blood to be obviously increased, so that the heart rate is accelerated, the blood flow is increased, the oxygen delivery capacity is improved, tricarboxylic acid circulation is promoted to be smoothly carried out, and energy is ensured to be continuously supplemented.

3. Vitamin preparation

Because vitamins participate in various metabolisms of organisms, and deficiency and insufficiency of the vitamins can generate adverse effects on the movement ability, the work output can be reduced, and exercise fatigue and the like are easy to occur. Comprehensive supplementation is better than single supplementation.

4. Candy

Is the main energy source substance of muscles during exercise, and the sources in the body are blood sugar, muscle glycogen and liver glycogen. During long-time exercise, energy supply and blood sugar concentration in the body are mainly maintained by the hydrolysis of muscle glycogen and liver glycogen. Before exercise, the intake of carbohydrate in vivo is increased, so that sugar intake and utilization of muscle can be increased, and hepatic glycogen decomposition can be reduced, thereby saving muscle glycogen and hepatic glycogen, improving exercise ability, delaying fatigue, and preventing sports injury.

The sugar of the sports drink is preferably compounded by a plurality of sugar sources of glucose, sucrose and oligosaccharide. Besides relieving insulin reaction, the preparation can also adjust osmotic pressure, improve flavor, stimulate various sugar absorption ways of human body, and promote the absorption and utilization of sugar and water.

5. Electrolyte

The function of the ionic metabolism in the exercise-induced fatigue is more and more emphasized by people, and the exercise-induced skeletal muscle fatigue can be caused by the disturbance of the ionic metabolism during exercise.

However, studies show that although caffeine can improve alertness, sensitivity and attention of people, caffeine can cause caffeine poisoning after long-term taking in a large amount, symptoms of caffeine are similar to anxiety, and caffeine can have certain negative effects on osteoporosis or hip fracture, and particularly, the caffeine can cause bone loss of people with low calcium intake. Taking functional beverages in large quantities for a long time may lead to addiction and even some mental disorders. Meanwhile, elements such as sodium in the functional beverage can increase the burden of the organism, and cause negative effects such as increased heart load, increased blood pressure and the like. Therefore, such functional beverages are not suitable for people with hypertension and heart disease.

The second type of anti-fatigue health care product mainly comprises anti-fatigue plant active ingredients which are researched more in the prior art. The following plants are mainly included:

1. ginseng radix

Ginseng (Panax ginseng C.A. Meyer) is a perennial herb of Panax of Araliaceae. Modern pharmacological research finds that ginseng contains various chemical components, mainly including ginsenoside, ginseng polysaccharide, polypeptide, fatty acid, amino acid, polyacetylene alcohol and the like. In recent years, multi-center animal and clinical experimental research at home and abroad prove that ginseng has the anti-fatigue effect, the basis of the anti-fatigue substance of ginseng is considered to be mainly ginsenoside, and related researches on the anti-fatigue effect mechanism of ginsenoside are performed from a plurality of angles of resisting free radicals, regulating carbohydrate metabolism, reducing lactic acid accumulation, resisting central neurotransmitter disorder and the like.

2. Rhizome of Siberian solomonseal

Rhizoma Polygonati (Polygonatum sibiricum) is rhizome of Polygonatum sibiricum of Polygonatum of Liliaceae, and has effects of invigorating spleen, moistening lung, and promoting fluid production. The rhizome contains polysaccharide, flavone, and microelements such as Fe, Mn, Cu, Zn, Ca, Mg, etc., wherein the rhizoma Polygonati polysaccharide has various biological functions and biological activities, and has effects in resisting bacteria, resisting oxidation, and relieving fatigue.

3. Rhodiola root

The radix Rhodiolae is perennial herb or shrub of Rhodiola L, and contains salidroside and tyrosol glycoside as main active ingredients, and phenols, flavonoids, coumarins, organic acids, and trace elements. A large number of researches show that the rhodiola rosea has the effects of reducing oxygen consumption rate, increasing exercise endurance, enhancing glycogen storage, improving aerobic metabolic processes of important organs such as heart and brain, obviously improving the content of glycogen in liver and cardiac muscle and improving the level of sodium element in heart and lung tissues of animals, thereby relieving organ damage caused by hypoxia.

4. Sea-buckthorn

Hippophae rhamnoides (Hippophae rhamnoides L.) is deciduous shrub or small tree of Hippophae of Elaeagnaceae (Hippophae rhamnoides L.), and is also called Hippophae Rhamnoides or Hippophae rhamnoides (Hippophae rhamnoides L.). Sea-buckthorn is one of the plants both as medicine and food, which is issued by Ministry of health in 1988, and contains a plurality of physiological active substances, wherein 14 vitamins, 12 organic acids and monosaccharides, 22 amino acids and amides, 7 fatty acids, 32 lipids, 30 phenols and flavonoids, 4 proteins and 29 trace elements are detected.

Research shows that the sea buckthorn has good functions of hypoxia tolerance, myocardial oxygen consumption reduction, oxidation resistance and the like, and also has the effects of immunity enhancement, auxiliary blood fat reduction and the like.

5. Tribulus terrestris

The Chinese pharmacopoeia records that the dried mature fruits of tribulus terrestris (Tribu-lus terrestris L.) belonging to family Zygophyllaceae are named as tribulus terrestris, tribulus terrestris and tribulus terrestris, and have the effects of calming liver, resolving stagnation, promoting blood circulation, dispelling wind, improving eyesight and relieving itching. Can be used for treating headache, vertigo, distending pain in chest and hypochondrium, milk retention, mammary abscess, conjunctival congestion, nebula, rubella and pruritus. Mainly contains saponins, flavonoids, alkaloids, polysaccharides, and other compounds, and also contains sterols, amino acids, terpenes, fatty acids, and inorganic salts.

The fructus Tribuli extract can prolong the time from running the platform to exhaustion of the rat, and has antifatigue effect; its antifatigue effect may be related to its increase in glycogen content, elevation of blood testosterone levels.

The health care product mainly develops active ingredients in traditional medicinal plants by means of modern technological development, clarifies the action mechanism of the active ingredients in a human body and achieves the anti-fatigue health care effect, but the health care product has the following problems. One is that the active substances are mostly extracted from natural plants at present, and traditional rare traditional Chinese medicines such as ginseng and rhizoma polygonati have a series of risks such as lack of wild resources, limited artificial planting yield and heavy metal pollution caused by pesticide residues. And secondly, the health-care products need a certain taking period to have a more obvious improvement effect. And thirdly, the medicine has more and single action components and is suitable for people or has limited effect.

And thirdly, the traditional Chinese medicine formula obtained through reasonable compatibility under the guidance of the traditional Chinese medicine theory is applied to the anti-fatigue health care product.

The traditional Chinese medicine considers that the main pathogenesis of fatigue type sub-health is spleen deficiency and liver depression with heart deficiency, the spleen governs muscles and limbs, and the spleen deficiency causes physical fatigue and weakness; the liver regulates qi movement and is good at mind, and depression of the liver tends to cause dysphoria or depression; heart governing mind is the major part of the five zang-organs and six fu-organs, and heart deficiency leads to dizziness, confusion of thinking and poor memory. Therefore, the main treatment policy of the traditional Chinese medicine in the treatment of fatigue is to soothe the liver, relieve depression, invigorate the spleen and replenish qi. However, because of the influence of actual environment and conditions, the traditional medicine is not found in the field of anti-fatigue health care products and medicines for building a large tree.

According to the theory of traditional Chinese medicine, the pathogenesis of chronic fatigue syndrome is caused by imbalance of yin and yang of the organism, imbalance of qi and blood, and imbalance of visceral functions due to factors such as congenital deficiency, loss of work and rest, abnormal daily life, improper diet, emotional and emotional disorders, non-tranquility of the living place, and senile and body weakness. The common symptoms comprise liver qi stagnation syndrome, liver depression and spleen deficiency syndrome, heart and spleen deficiency syndrome, liver and kidney yin deficiency syndrome, lung and spleen qi deficiency syndrome, spleen deficiency and dampness obstruction syndrome, liver depression and fire transformation syndrome, and phlegm heat internal disturbance syndrome, and the main disease is in liver, spleen and kidney.

The common clinical manifestations can be divided into the following categories

The physical symptoms such as fatigue, sleep disorder, pain and the like are mainly expressed;

secondly, the mental and psychological symptoms such as depression, fright, uneasiness, irritability, fear, timidity, short-term memory decline, attention failure to concentrate and the like are mainly expressed;

the social adaptability reduction such as reduction of interpersonal interaction frequency or tension of interpersonal relationship is taken as the main point;

at present, western medicines are not considered to be chemical components or medicines capable of effectively treating CFS, only can relieve partial symptoms and improve functional state, and a plurality of medicines have adverse reactions.

The traditional Chinese medicine adopts the traditional Chinese medicine to treat chronic fatigue syndrome by internal treatment, and a plurality of documents show that the traditional Chinese medicine has good effect; .

Disclosure of Invention

The invention aims to provide an anti-fatigue health-care product and a preparation method thereof, and aims to solve the problems that the existing anti-fatigue health-care product proposed by the background art can cause adverse reactions of a human body, neglects psychological fatigue and mental fatigue, takes effect slowly and has complex preparation conditions when being taken by the human body for a long time.

In order to achieve the purpose, the invention provides the following technical scheme: an anti-fatigue health product, which comprises the following raw materials: malt, Chinese date, astragalus, medlar, yam, mint, green tea and additives.

Preferably, the additives are Chinese pine node and nardostachys root.

Preferably, the additives are chrysanthemum and tremella.

Preferably, the anti-fatigue health care product consists of the following components in parts by weight: 1-20 parts of malt, 1-20 parts of Chinese date, 1-10 parts of astragalus root, 1-5 parts of wolfberry fruit, 1-5 parts of Chinese yam, 1-5 parts of mint, 1-5 parts of green tea and an additive consisting of 1-10 parts of Chinese pine nodular branch and 1-5 parts of nardostachys root.

Preferably, the anti-fatigue health care product consists of the following components in parts by weight: 1-20 parts of malt, 1-20 parts of Chinese date, 1-10 parts of astragalus root, 1-5 parts of wolfberry fruit, 1-5 parts of Chinese yam, 1-5 parts of mint, 1-5 parts of green tea and an additive consisting of 1-5 parts of chrysanthemum and 0.1-5 parts of tremella.

Preferably, the anti-fatigue health care product consists of the following components in parts by weight: 10-20 parts of malt, 5-15 parts of Chinese date, 5-10 parts of astragalus, 2-4 parts of wolfberry fruit, 2-4 parts of Chinese yam, 2-4 parts of mint, 1-3 parts of green tea, 5-10 parts of Chinese pine node and 2-4 parts of nardostachys root.

Preferably, the anti-fatigue health care product consists of the following components in parts by weight: 18 parts of malt, 8 parts of Chinese date, 6 parts of astragalus root, 3 parts of wolfberry fruit, 2 parts of Chinese yam, 2 parts of mint, 1 part of green tea, 6 parts of Chinese pine node and 2.4 parts of nardostachys root.

Preferably, the anti-fatigue health care product consists of the following components in parts by weight: 10-20 parts of malt, 5-15 parts of Chinese date, 5-10 parts of astragalus, 2-4 parts of wolfberry fruit, 2-4 parts of Chinese yam, 2-4 parts of mint, 1-3 parts of green tea, 1-4 parts of chrysanthemum and 0.1-3 parts of tremella.

Preferably, the anti-fatigue health care product consists of the following components in parts by weight: 18 parts of malt, 8 parts of Chinese date, 6 parts of astragalus root, 3 parts of wolfberry fruit, 2 parts of Chinese yam, 2 parts of mint, 1 part of green tea, 2 parts of chrysanthemum and 0.6 part of tremella.

The invention provides another technical scheme for providing a preparation method of an anti-fatigue health-care product, which comprises the following steps:

the method comprises the following steps: when chrysanthemum and tremella are selected as additives for preparation, high-quality malt, Chinese date, astragalus, medlar, yam, tremella and chrysanthemum are selected, washed first and added with clear water with the dry weight of 8-12 times, and then placed in an extraction container for soaking for 12 hours in advance. Cleaning the superior mint and green tea, adding clear water with the weight 4-6 times of the dry weight, taking another container, and putting the container into the container for soaking for 2 hours in advance;

step two: decocting fructus Hordei Germinatus for 1.5 hr, adding soaked herba Menthae and green tea, decocting for 0.5 hr, filtering to obtain first medicinal liquid, adding the residue into the first-extracted clear water, decocting for 2-3 hr for 1-2 times, mixing the medicinal liquids, and filtering;

step three: concentrating the above medicinal liquid under boiling state to obtain fluid extract;

step four: adding maltose 2-3 times or Mel 1-2 times of the fluid extract, stirring to obtain paste, and pulling flag or dripping water to form bead;

step five: the judgment standard of the third step is that no water mark exists on the upper edge of mulberry paper or herbal paper medicine liquid which is dropped on the mulberry paper or herbal paper;

step six: when the Chinese pine nuts and the nardostachys chinensis batal are selected as the additives for preparation, the tremella fuciformis obtained in the first step to the fourth step is replaced by the Chinese pine nuts, and the chrysanthemum is replaced by the nardostachys chinensis batal.

Compared with the prior art, the invention has the beneficial effects that: the anti-fatigue health product and the preparation method thereof are prepared based on the guidance of the theory of traditional Chinese medicine, have the advantages that the main components are selected from medicinal and edible medicinal materials without toxic or side effect, the application crowd is wide, the effect is quick and good, the preparation is simple and the like, the effect of tonifying spleen and qi has good treatment and relief effect on fatigue caused by various factors, and the anti-fatigue health product has the effect of strengthening body resistance and consolidating the foundation, and is mild in medicine property and suitable for long-term administration;

the prescription selects the nardostachys chinensis batal and the Chinese pinecone, and the nardostachys chinensis batal, the malt and the Chinese date in the prescription have the functions of tonifying spleen and nourishing blood and are combined with the astragalus root to play the roles of tonifying qi and nourishing blood; the four medicines of the nardostachys chinensis bunge, the mint, the malt and the green tea are used together to play the effects of activating spleen and nourishing spirit, and soothing liver and relieving depression; the combination of the Chinese medicinal herbs of the Chinese pine knot, the Chinese date, the medlar and the Chinese yam has the effects of nourishing the acquired constitution and supplementing the innate constitution; the functions of tonifying, non-diarrhea, qi-blood nourishing and spleen-stomach coordination are combined above to achieve the effects of benefiting qi, nourishing blood, removing blood stasis and resisting diseases, and if tremella and chrysanthemum are adopted, the effects of tonifying spleen and nourishing blood of malt and Chinese date and the astragalus root are combined together to achieve the effects of benefiting qi and nourishing blood; the chrysanthemum, the mint, the malt and the green tea are used together to play the roles of activating spleen and nourishing spirit, and soothing liver and relieving depression; the combination of the four medicines of the tremella, the Chinese date, the medlar and the yam has the effects of nourishing the acquired foundation and supplementing the innate foundation;

1. the scheme adopts the mint, the mint oil is the main chemical component in the mint, the fresh mint leaves contain 0.8-1% of volatile oil, the dry stem leaves contain 1.3-2% of volatile oil, phenolic compounds, amino acids, various trace elements and other non-volatile components, the main component in the mint volatile oil is levomenthol (Mentho1) with the content of 62-87%, and more than 60 sesquiterpene volatile components such as levomenthol, isomenthone, pulegone and the like are also contained, and the small amount of mint oil can stimulate central nerves of a human body through oral administration, expand capillary vessels of the skin, promote secretion of sweat glands, increase heat dissipation, have the effects of sweating and fever reduction, and simultaneously can resist early pregnancy, implantation, inhibit uterine contraction, resist fungi and resist viruses; the non-volatile components have liver protecting, gallbladder promoting, anti-tumor, hair blackening, and antioxidant effects;

meanwhile, the mint is the dry overground part of mint (Mentha haplocalyx Briq.) of a Labiatae plant, is pungent in taste, cool in nature, enters lung and liver channels, disperses wind and heat, clears head and eyes, relieves sore throat, promotes eruption, soothes liver and promotes qi circulation, and is a traditional medicine and food dual-purpose plant;

2. the scheme adopts Chinese dates which have more complex components, and chemical components such as triterpenes, saponins, alkaloids, flavonoids, glycosides, nucleosides, saccharides, proteins, amino acids, vitamins, amides, organic acids, steroids and the like are separated from the Chinese dates in sequence until today, the Chinese dates also have multiple pharmacological activities and health-care effects, mainly have the effects of increasing cAMP in leucocytes, resisting allergic reaction, inhibiting nerves, protecting livers, enhancing muscle strength, resisting cancers, resisting mutation, resisting lipid peroxidation and the like, and are clinically used for treating diseases such as allergic purpura, non-thrombocytopenic purpura, hemorrhoidal bleeding, chronic atrophic gastritis, ulcer, diarrhea, infantile asthma, skin cancer and the like;

meanwhile, the Chinese date is a dry mature fruit of a Rhamnaceae plant Chinese date (Ziziphus jujuba Mill.), the fruit is harvested, dried, sweet and warm in autumn when ripe, enters spleen, stomach and heart channels, supplements middle warmer and benefits qi, nourishes blood and tranquilizes, and is used for spleen deficiency and poor appetite, debilitation and loose stool, women's hysteria, Chinese date germplasm resources are very rich and account for more than 98% of the total amount of the world, and the Chinese date is a traditional medicine-food homologous variety and contains abundant saccharide substances such as polysaccharide, cellulose and fructose, organic acid and ester substances thereof, saponin substances, flavonoid substances, vitamins, proteins, amino acids, mineral elements and other chemical components;

3. the scheme adopts nardostachys chinensis which contains terpenoids, flavonoids, coumarins, lignans and volatile oil, and also contains saccharides, inorganic elements and other chemical components, and has the effects of clearing heat, detoxifying and diminishing inflammation, and meanwhile, the nardostachys chinensis has the effects of resisting epilepsy, convulsion, depression, malaria, bacteria, inflammation, arrhythmia, oxidation, anxiety, blood sugar metabolism and the like;

meanwhile, the Nardostachys chinensis (L.) Merr is a dry root and rhizome of Nardostachys chinensis (Nardostachys jatamansi DC) of Valerianaceae, is pungent and sweet in taste, warm in nature, and capable of entering spleen and stomach channels, regulating qi to alleviate pain, relieving depression and activating spleen, externally used for eliminating dampness and reducing swelling, and researches on chemical components of the Nardostachys chinensis (L.) Merr have been reported at present, wherein the Nardostachys chinensis (L.) Merr comprises polysaccharides, organic acids, flavonoids, phenylpropanoids, terpenes, volatile oil and the like, and the main components are terpenes and volatile oil, so that the Nardostachys chinensis (L.) Merr has pharmacological effects of resisting depression and;

4. the scheme adopts the medlar which is a Chinese herbal medicine with sweet nature, and the pharmacological effects of the medlar are tonifying kidney and nourishing yin, treating consumptive disease and quenching thirst;

meanwhile, the medlar is a dry mature fruit of Ningxia medlar (Lycium barbarum L) of Solanaceae, is a traditional medicine-food dual-purpose tonifying traditional Chinese medicine, has mild nature and sweet taste, belongs to liver and kidney channels, has the effects of nourishing liver and kidney, replenishing vital essence and improving eyesight, and modern research shows that the medlar contains rich medlar polysaccharide, betaine, medlar pigment and other substances, wherein the medlar polysaccharide has the effects of enhancing the immunity of human bodies and animals, resisting aging, preventing tumors, resisting fatigue, preventing radiation, protecting and nourishing the liver and the like, and the medlar pigment has an important effect on resisting oxidation;

5. the scheme adopts astragalus membranaceus, 11 active ingredients in the astragalus membranaceus comprise 6 flavonoid ingredients including calycosin glucoside, calycosin, formononetin, isoflavan and pterocarpan, saponin ingredients of astragalus membranaceus, including saponin ingredients of astragalus membranaceus I, II, III and IV4 and cane sugar, the astragalus membranaceus mainly relates to biological processes of nitric oxide biosynthesis, hydrogen peroxide reaction, positive regulation of brown fat cell differentiation, active oxygen metabolism and the like, and the anti-fatigue effect is achieved by regulating cancer channels, FoxO, phosphatidylinositol 3-kinase (PI3K) -protein kinase B (Akt), hypoxia inducible factor-1 (HIF-1), Vascular Endothelial Growth Factor (VEGF), Mitogen Activated Protein Kinase (MAPK), Ca2+ signal channels, oxidative stress reaction and the like;

meanwhile, the Astragalus membranaceus is the dried root of leguminous plant Astragalus mongholicus (Fisch.) membranaceus (Bge.) Bge. Hsiao or Astragalus membranaceus (Fisch.) membranaceus (Bge.) Bge. spring and autumn, fibrous root and root head are removed, and the Astragalus membranaceus is dried, sweet and slightly warm and enters lung and spleen channels, and is listed as the superior product by Shen nong Bencao Jing as the traditional Chinese medicine and food tonifying medicine, the Astragalus membranaceus is considered as a good qi tonifying medicine in the traditional Chinese medical science, the Astragalus membranaceus is called as 'ten medicines eight Astragalus membranaceus', the Astragalus membranaceus has the effects of tonifying qi and raising yang, consolidating exterior and arresting sweating, inducing diuresis and reducing edema, nourishing blood, promoting the circulation of qi and dredging arthralgia and the like, is commonly used for loose stool, sinking of qi, deficiency and spontaneous sweating, edema due to deficiency, internal heat and thirst quenching and the like, and the main components of the Astragalus membranaceus comprise flavonoids, saccharides, organic acids, amino acids, the research on the anti-fatigue, the anti-inflammatory literature shows that the modern pharmacology research has the pharmacological effect, the astragaloside obviously improves the Peroxidase (POD) level, the total antioxidant capacity (T-AOC) and the activity of Ca2+ -Mg2+ -ATP enzyme of skeletal muscle of a rat with sports fatigue, reduces the content of Lactate Dehydrogenase (LDH), has the function of protecting muscle tissue of the rat with sports fatigue, the flavonoid component in the astragalus and fingerprint chromatogram peaks of other components (containing saponins) have the function of enhancing anti-fatigue effect, the astragalus polysaccharide can prolong the negative gravity exhaustion swimming time of the mouse, reduce the accumulation of blood lactic acid of the organism, increase the storage of liver glycogen, play the roles of delaying fatigue generation/improving the sports ability, improve the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in liver tissue of the mouse, have the function of resisting oxidative damage, and can protect oxidative stress induced by sports

6. The chrysanthemum is adopted in the scheme, the effective components in the chrysanthemum comprise volatile oil, amino acid, flavonoid, trace vitamin B and the like, pharmacological research shows that the chrysanthemum has the function of resisting pathogens, has a certain inhibition effect on gram-positive bacteria and human tubercle bacillus in vitro, and can also enhance the resistance of capillary vessels, inhibit the permeability of the capillary vessels and have the anti-inflammatory effect;

meanwhile, Chrysanthemum is a dry head-shaped inflorescence of Chrysanthemum (Chrysanthemum morifolium Ramat) of the Compositae, medicinal materials are divided into Chrysanthemum morifolium, Chrysanthemum morifolium and Chrysanthemum indicum according to different production places and processing methods, and the Chrysanthemum morifolium, Chrysanthemum indicum, Chrysanthemum morifolium, Chrysanthemum: ju can promote the five vessels, regulate the four limbs, treat head wind heat; is a medicine and food dual-purpose variety; modern pharmacological studies show that: the chrysanthemum is rich in volatile oil and flavonoid, and also contains various physiological active substances such as chlorogenic acid, polysaccharide, phenols, fatty acid, trace elements and the like, and related experiments show that the chrysanthemum extract has the effects of resisting fatigue and aging;

7. the scheme adopts the green tea, the green tea extract is the most effective substance for resisting the fatigue of the anaerobic exercise, the green tea extract can effectively relieve the fatigue state of the body of the athlete after the anaerobic exercise, and simultaneously can quickly recover the body of the athlete to the normal state, thereby ensuring good exercise performance and the body health of the athlete, and meanwhile, the substance is nontoxic and free of stimulant components, and can control the serum level, slow down the metabolism of free radicals, protect skeletal muscles, protect kidney and the like;

meanwhile, the green tea is one of the main tea types in China, is one of the traditional medicine and food homologous varieties, contains tea polyphenol, catechin, chlorophyll, caffeine, amino acid, vitamins and other nutritional ingredients, and numerous researches show that the green tea has multiple effects of regulating glycolipid metabolism, improving cardiovascular diseases, resisting cancer, resisting oxidation and the like, and meanwhile, modern pharmacological researches also prove that the green tea has good fatigue resistance and effectively relieves the fatigue state of the human body after anaerobic exercise, and simultaneously helps to quickly recover the body to a normal state, the tea polyphenol is a main ingredient for determining the color, the fragrance, the taste and the effect of the tea and accounts for 20-30% of the dry weight of the tea, and related researches show that the tea polyphenol has good anti-exercise fatigue effect;

8. the malt adopted in the scheme has sweet taste and mild nature, and has the functions of invigorating qi, promoting digestion, strengthening spleen, stimulating appetite, removing milk and relieving flatulence, and is used for treating indigestion, abdominal distension and pain, spleen deficiency and anorexia, milk stasis, breast gall, women's lactation cessation, raw malt, spleen strengthening, stomach harmonizing and lactation promotion, and spleen deficiency and anorexia and milk stasis; parched fructus Hordei Germinatus has effects of activating qi-flowing, resolving food stagnation, and promoting lactation, and can be used for treating indigestion and lactation interruption of women; the scorched malt is used for promoting digestion and resolving stagnation, is used for treating indigestion and abdominal distending pain, and is a common digestion-promoting medicine in clinical traditional Chinese medicine;

meanwhile, the malt is a processing product obtained by germinating and drying mature fruits of gramineous plant barley (Hordeurn vulgare L.), is sweet, neutral, enters spleen and stomach channels, has the effects of promoting qi circulation to promote digestion, strengthening spleen to stimulate appetite and the like, is one of medicinal and edible varieties published by Weijian, and is recorded in the Chinese pharmacopoeia 2015 edition: the raw malt has the effects of strengthening spleen and stomach, soothing liver and promoting qi circulation, is used for treating spleen deficiency and anorexia and liver depression and qi stagnation, and is a wonderful product for soothing liver and relieving depression;

9. the scheme adopts Chinese yam, particularly Tiegun Chinese yam, which is rich in polysaccharide and is an important active substance, wherein the Chinese yam polysaccharide is a main active component in the Chinese yam, mainly comprises mannose, xylose, arabinose, glucose and galactose, and has rich pharmacological activity;

meanwhile, the yam is a dry rhizome of Dioscorea opposita (Dioscorea opposita L.) belonging to the family Dioscoreaceae, is a traditional medicine and food dual-purpose plant, has the advantages of mild nature and sweet taste, and has the effects of invigorating spleen, lung and kidney channels, tonifying spleen and nourishing stomach, promoting the production of body fluid and benefiting lung, and tonifying kidney essence, and is used for treating spleen deficiency and poor appetite, chronic diarrhea, lung deficiency and cough, kidney deficiency and spermatorrhea, leukorrhagia, frequent micturition, asthenic fever and diabetes, and the yam contains starch, fat, protein and various mineral nutritive elements as well as various components such as zaixe, phenols, polysaccharides and the like according to the reports at home and abroad, and related experiments show that the yam can play a good anti-fatigue effect when being directly taken as a food, and also play a certain role in recovering sports fatigue, and related pharmacological researches prove that the yam polysaccharide has a good anti-fatigue and anti;

10. according to the scheme, tremella is adopted, is an edible fungus, has the effects of tonifying spleen, stimulating appetite, nourishing yin, moistening lung and the like, and has wide pharmacological effects such as immunoregulation, tumor resistance, oxidation resistance, blood sugar and blood fat reduction and the like as tremella polysaccharide is taken as one of main active ingredients;

meanwhile, the Tremella fuciformis is Tremella fuciformis Berk (TF), also called as Tremella fuciformis and Tremella fuciformis, belongs to the Tremella family of basidiomycetes, is a tonic for treating weakness and aging, enters the lung, stomach and kidney meridians, has the effects of nourishing yin and tonifying lung, nourishing stomach and promoting the secretion of saliva or body fluid, tonifying kidney and replenishing vital essence and calming mind, is used as a traditional edible fungus and is named as 'crown in fungus', is regarded as a famous and precious tonic good product which is a palace life prolonging tribute during clearing, contains protein, fat and 17 amino acids and mineral substances, and researches on the Tremella fuciformis prove that the Tremella fuciformis polysaccharide has various effects of oxidation resistance, tumor resistance, immunoregulation, blood sugar and fat reduction, radiation resistance, virus resistance and the like;

11. in the scheme, the Chinese pine node is adopted, the volatile oil in the Chinese pine node has special fragrance, and the Chinese pine node is favorable for activating blood and relieving pain and is favorable for resisting fatigue;

meanwhile, the Chinese pine node is a dry nodular node or a branch node of Pinus tabulaeformis (Pinus tabulieformis Carr.) or Pinus massoniana lamb (Pinus assassiana lamb.) belonging to Pinaceae, can be harvested all the year round, is sawed and dried in the shade, is bitter and pungent in taste, warm in nature, enters liver and kidney meridians, and has the effects of dispelling wind and removing dampness, and dredging collaterals and relieving pain.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention provides a technical scheme that: an anti-fatigue health product, which comprises the following raw materials: malt, Chinese date, astragalus, medlar, yam, mint, green tea and additives.

In the invention, the addition materials are Chinese pine node and nardostachys root.

In the invention, the additives are chrysanthemum and tremella.

The invention further discloses an anti-fatigue health-care product which is prepared from the following components in parts by weight: 1-20 parts of malt, 1-20 parts of Chinese date, 1-10 parts of astragalus root, 1-5 parts of wolfberry fruit, 1-5 parts of Chinese yam, 1-5 parts of mint, 1-5 parts of green tea and an additive consisting of 1-10 parts of Chinese pine nodular branch and 1-5 parts of nardostachys root.

The invention further discloses an anti-fatigue health-care product which is prepared from the following components in parts by weight: 1-20 parts of malt, 1-20 parts of Chinese date, 1-10 parts of astragalus root, 1-5 parts of wolfberry fruit, 1-5 parts of Chinese yam, 1-5 parts of mint, 1-5 parts of green tea and an additive consisting of 1-5 parts of chrysanthemum and 0.1-5 parts of tremella.

The invention further discloses an anti-fatigue health-care product which is prepared from the following components in parts by weight: 10-20 parts of malt, 5-15 parts of Chinese date, 5-10 parts of astragalus, 2-4 parts of wolfberry fruit, 2-4 parts of Chinese yam, 2-4 parts of mint, 1-3 parts of green tea, 5-10 parts of Chinese pine node and 2-4 parts of nardostachys root.

The invention further discloses an anti-fatigue health-care product which is prepared from the following components in parts by weight: 18 parts of malt, 8 parts of Chinese date, 6 parts of astragalus root, 3 parts of wolfberry fruit, 2 parts of Chinese yam, 2 parts of mint, 1 part of green tea, 6 parts of Chinese pine node and 2.4 parts of nardostachys root.

The invention further discloses an anti-fatigue health-care product which is prepared from the following components in parts by weight: 10-20 parts of malt, 5-15 parts of Chinese date, 5-10 parts of astragalus, 2-4 parts of wolfberry fruit, 2-4 parts of Chinese yam, 2-4 parts of mint, 1-3 parts of green tea, 1-4 parts of chrysanthemum and 0.1-3 parts of tremella.

The invention further discloses an anti-fatigue health-care product which is prepared from the following components in parts by weight: 18 parts of malt, 8 parts of Chinese date, 6 parts of astragalus root, 3 parts of wolfberry fruit, 2 parts of Chinese yam, 2 parts of mint, 1 part of green tea, 2 parts of chrysanthemum and 0.6 part of tremella.

The formula can be prepared into different dosage forms, such as oral liquid, tablets, capsules, paste, granules, pills, powder, solution and the like, and the different dosage forms can be used as a health-care product.

Example (b):

selecting 60 clinical subjects mainly suffering from fatigue, 40 male subjects, 20 female subjects, the maximum age of 45 years, the minimum age of 22 years, the average age of 33.2 years and the course of disease of 3 months to 1 year;

after excluding other diseases causing fatigue, reference is made to "sub-health clinical guidelines", which is divided into two groups of 30 persons each.

Two groups of subjects take oral liquid (prepared from rhizoma Nardostachyos, lignum Pini nodi/flos Chrysanthemi, and Tremella) prepared by decocting two groups of Chinese medicinal materials, 15g each time, and continuously taking with boiled water for 15 days. Evaluating the curative effect according to the following standard after the treatment course is finished;

and (3) curing: fatigue and other complications substantially disappear;

the curative effect is remarkable; fatigue and other complications partially disappear and the rest are effectively relieved;

the method is effective; fatigue and its complications are effectively relieved but not eliminated;

invalid; the symptoms are not obviously improved compared with the symptoms before the medicine taking;

the experimental results are as follows:

taking the following medicines: 20 patients are cured, the obvious curative effect is 6 patients, the effective is 4 patients, and no ineffective cases exist;

taking Tremella and flos Chrysanthemi; cure 18 people, have remarkable curative effect of 7 people, have 5 effective people and have no invalid case.

The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

The above description is only for the specific embodiments of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present application, and all the changes or substitutions should be covered by the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims

1. An anti-fatigue health product, which is characterized in that: the anti-fatigue health product comprises the following raw materials: malt, Chinese date, astragalus, medlar, yam, mint, green tea and additives.

2. The anti-fatigue health product according to claim 1, wherein: the additive is lignum Pini nodi and rhizoma Nardostachyos.

3. The anti-fatigue health product according to claim 1, wherein: the additives are chrysanthemum and tremella.

4. The anti-fatigue health product according to claim 2, wherein: the anti-fatigue health product comprises the following components in parts by weight: 1-20 parts of malt, 1-20 parts of Chinese date, 1-10 parts of astragalus root, 1-5 parts of wolfberry fruit, 1-5 parts of Chinese yam, 1-5 parts of mint, 1-5 parts of green tea and an additive consisting of 1-10 parts of Chinese pine nodular branch and 1-5 parts of nardostachys root.

5. The anti-fatigue health product according to claim 3, wherein: the anti-fatigue health product comprises the following components in parts by weight: 1-20 parts of malt, 1-20 parts of Chinese date, 1-10 parts of astragalus root, 1-5 parts of wolfberry fruit, 1-5 parts of Chinese yam, 1-5 parts of mint, 1-5 parts of green tea and an additive consisting of 1-5 parts of chrysanthemum and 0.1-5 parts of tremella.

6. The anti-fatigue health product according to claim 4, wherein: the anti-fatigue health product comprises the following components in parts by weight: 10-20 parts of malt, 5-15 parts of Chinese date, 5-10 parts of astragalus, 2-4 parts of wolfberry fruit, 2-4 parts of Chinese yam, 2-4 parts of mint, 1-3 parts of green tea, 5-10 parts of Chinese pine node and 2-4 parts of nardostachys root.

7. The anti-fatigue health product according to claim 6, wherein: the anti-fatigue health product comprises the following components in parts by weight: 18 parts of malt, 8 parts of Chinese date, 6 parts of astragalus root, 3 parts of wolfberry fruit, 2 parts of Chinese yam, 2 parts of mint, 1 part of green tea, 6 parts of Chinese pine node and 2.4 parts of nardostachys root.

8. The anti-fatigue health product according to claim 5, wherein: the anti-fatigue health product comprises the following components in parts by weight: 10-20 parts of malt, 5-15 parts of Chinese date, 5-10 parts of astragalus, 2-4 parts of wolfberry fruit, 2-4 parts of Chinese yam, 2-4 parts of mint, 1-3 parts of green tea, 1-4 parts of chrysanthemum and 0.1-3 parts of tremella.

9. The anti-fatigue health product according to claim 8, wherein: the anti-fatigue health product comprises the following components in parts by weight: 18 parts of malt, 8 parts of Chinese date, 6 parts of astragalus root, 3 parts of wolfberry fruit, 2 parts of Chinese yam, 2 parts of mint, 1 part of green tea, 0.6 part of tremella and 2 parts of chrysanthemum.

10. A preparation method of an anti-fatigue health product is characterized by comprising the following steps: the preparation method of the anti-fatigue health product comprises the following steps:

the method comprises the following steps: when chrysanthemum and tremella are selected as additives for preparation, high-quality malt, Chinese date, astragalus, medlar, yam, tremella and chrysanthemum are selected for rush washing, and are put into an extraction container for soaking in advance for 12 hours by adding clear water with the dry weight of 8-12 times. Cleaning the superior mint and green tea, adding clear water with the weight 4-6 times of the dry weight, taking another container, and putting the container into the container for soaking for 2 hours in advance;