CN103417911B - Traditional Chinese medicine composition for supporting chemo-treatment - Google Patents
Traditional Chinese medicine composition for supporting chemo-treatment Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for supporting chemo-treatment. The composition comprises the following components: pangolin scales, membranous milkvetch root, curcuma aromatica, grape leaf, ginseng, radix linderae, giant knotweed, calculus bovis, laminaria, nostoc commune, cactus, pearl, realgar, croci stigma, centipede, bittersweet herb, trichosanthes root, black nightshade, radix rehmanniae recen, verbena, white paeony root, ganoderma, rhizome sparganii, fructus evodiae, puccoon, andrographis paniculata, deerhorn glue, bulb of edible tulip, daphne giraldii nitsche, and ramie root. The composition provided by the invention has the advantages of quick curative effect, high efficiency and small side effect aiming to the side effects caused by chemo-treatment.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition being used for the treatment of the side effect that chemotherapy causes.
Background technology
Effective treatment still mainly operation, chemotherapy, radiotherapy so far of tumor, but, there is the patient of 80% will be obtained the existence of longer time by chemotherapy, radiotherapy.But chemotherapy cause as toxicities such as bone marrow transplantation, hypoimmunity, gastrointestinal reactions, make patient be difficult to adhere to.The General Symptoms that chemotherapeutics causes comprises dizziness, fatigue and weak, lethargy, is off one's feed, insomnia and dreamful sleep, dry mouth and lack of saliva, defecation imbalance etc.Namely can increase curative effect as being aided with treatment by Chinese herbs, can avoid or alleviate again the toxicity of chemicotherapy to a certain extent, extend life cycle and the life quality of patient.Existing Chinese medicinal formulae is nursed one's health above-mentioned side effect mainly through following four aspects: 1. replenishing essence of enriching blood: 2. QI invigorating consolidates, and improves immunity: 3. regulating the stomach and sending down the abnormal ascending QI: alleviate the gastrointestinal reactions such as Nausea and vomiting; 4. tonifying speen and tonifying kidney.Above-mentioned side effect also can be summarized as 4 large classes: 1. digestive tract reaction: gastrointestinal mucosal cell is often subject to the damage of Treated with Chemotherapeutic Drugs thing, causes a series of digestive tract reaction, generally compared with the morning that bone marrow depression occurs.As: loss of appetite, nausea and vomiting, abdominal pain diarrhea etc. are that taste are become estranged, the performance of disorder in ascending and descending, and Chinese traditional treatment is mainly based on invigorating the spleen and regulating the stomach, sending down the abnormal ascending QI emesis, and medicine has: Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Caulis Bambusae In Taenia etc.2. bone marrow depression: most antitumor drug all can cause bone marrow depression in various degree, and main manifestations is the decline of peripheral blood leucocyte, drops to master with neutrophilic granulocyte, some medicines make platelet decline obviously.When more serious, can granulocyte colony-stimulating factor be given, but bone marrow depression recondition slowly patient add with can shorten after treatment by Chinese herbs hemogram recover time.Medicine: Fructus Ligustri Lucidi, Fructus Corni etc.3. immunosuppressant: the immunoreation calibration ordinary person of late tumor patient is low, and the immune state of most antitumor drug on body has impact in various degree.Tumor, body's immunity state and Drug therapy interphase interaction are very complicated.Medicine inhibits the immunologic function of body while killing off tumor cells, and the latter is again for the diffusion of tumor cell provides condition.So both protected immunologic function and the resistance against diseases of body with Chinese medicine adjustment, there is the growth that inhibit tumor to a certain extent.4. nerve injury: the medicine of some plant bases exists neurotoxicity.As vincristine, paclitaxel, numb limbs and tense tendons, general weakness, knee jerk can be caused low, enteroparalysis, constipation, ataxia etc.Treatment is conventional: Caulis Trachelospermi, Caulis Spatholobi etc.
In order to slow down or eliminate above-mentioned side effect, use Chinese medicine to treat the side effect that chemotherapy causes and achieve certain effect, but still need more effective prescription, fast can meet curative effect, effective percentage is high, the demand that side effect is little.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of novel to be used for the treatment of Chinese medicine composition of the side effect that chemotherapy causes and preparation method thereof, this Chinese medicine composition is adopted to have curative effect to the treatment being used for the treatment of the side effect that chemotherapy causes fast, the advantages such as effective percentage is high, the demand that side effect is little.
In order to solve the problems of the technologies described above; the invention provides a kind of Chinese medicine composition being used for the treatment of the side effect that chemotherapy causes; it comprises: Squama Manis, the Radix Astragali, Radix Curcumae, grape leaf, Radix Ginseng, the Radix Linderae, Rhizoma Polygoni Cuspidati, Calculus Bovis, Thallus Laminariae (Thallus Eckloniae), ear, Radix et Caulis Opuntiae Dillenii, Margarita, Realgar, Stigma Croci, Scolopendra, Herba Solani Lyrati, Radix Trichosanthis, Herba Solani Nigri, Radix Rehmanniae, Herba Verbenae, the Radix Paeoniae Alba, Ganoderma, Rhizoma Sparganii, Fructus Evodiae, Radix Arnebiae (Radix Lithospermi), Herba Andrographis, Colla cornus cervi, Bulbus Tulipae, Daphne giraldii Nitsche, Radix Boehmeriae.
Wherein, the ratio of weight and number of various component is, Squama Manis 10-40 weight portion, Radix Astragali 10-40 weight portion, Radix Curcumae 5-10 weight portion, grape leaf 5-25 weight portion, Radix Ginseng 5-20 weight portion, Radix Linderae 10-20 weight portion, Rhizoma Polygoni Cuspidati 10-20 weight portion, Calculus Bovis 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-30 weight portion, ground ear 10-25 weight portion, Radix et Caulis Opuntiae Dillenii 10-20 weight portion, Margarita 10-15 weight portion, Realgar 5-10 weight portion, Stigma Croci 10-20 weight portion, Scolopendra 10-15 weight portion, Herba Solani Lyrati 10-15 weight portion, Radix Trichosanthis 5-10 weight portion, Herba Solani Nigri 5-10 weight portion, Radix Rehmanniae 10-25 weight portion, Herba Verbenae 10-15 weight portion, Radix Paeoniae Alba 10-25 weight portion, Ganoderma 10-25 weight portion, Rhizoma Sparganii 10-25 weight portion, Fructus Evodiae 10-25 weight portion, Radix Arnebiae (Radix Lithospermi) 10-20 weight portion, Herba Andrographis 10-20 weight portion, Colla cornus cervi 10-25 weight portion, Bulbus Tulipae 10-15 weight portion, Daphne giraldii Nitsche 10-15 weight portion, Radix Boehmeriae 10-15 weight portion.
Wherein, described Chinese medicine composition dosage form can be decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, colloid or syrup.
For solving the problems of the technologies described above, present invention also offers the preparation method of the above-mentioned Chinese medicine composition of different dosage form:
The preparation method of powder: after taking raw material, crude drug is pulverized, sieving, fully powder is made in mixing.
The preparation method of granule: the first step, each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, carry out decoction process 1 ~ 3 hour, decoction liquor is filtered, concentration, obtain the mastic removing moisture, be the ethanol of 65% ~ 75% by adding relative to the determining alcohol of first step mixture quality 3 ~ 5 times in the mastic of acquisition, carry out stirring 20 minutes ~ 40 minutes, cold preservation 1 ~ 2 hour at 0 ~ 4 DEG C, filter, decompression recycling ethanol, obtain and get dry extract, dry, be ground into 20 order ~ 200 object powder, obtain Chinese medicine composition additive granules.
The preparation method of powder: each component in described Chinese medicine composition additive be mixed in proportion, obtains mixture, after being pulverized by crude drug mixture, after first medical material being soaked 2 hours with ethanol, alcohol reflux 2 times, each 2 hours, merging filtrate was also condensed into paste; Filtering residue uses water extraction 2 times again, and first time extracts 2.5 hours, and second time is extracted 1.5 hours, and filter, merging filtrate is also condensed into paste; Merge extractum, finally add appropriate amount of starch and dextrin (or other adjuvant), mix homogeneously, dry, pulverize, be namely prepared into powder.
Decoction preparation method: each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, after crude drug mixture is pulverized, after medical material being soaked 1-2 hour with water, then decoct to boiling with high heat, then use slow fire boiling 30 minutes, filter, filtering residue adds water with slow fire boiling twice, each 1 hour.Merging filtrate, adding ethanol content in ethanol to filtrate after filtrate is concentrated is 70%, filters, filtrate recycling ethanol, and concentrated, filtration, embedding, sterilizing, be namely prepared into oral liquid.
Injection preparation method: each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, after crude drug mixture is pulverized, after medical material being soaked 1-2 hour with water, then decoct to boiling with fire, then decoct 30 minutes with little fire, filter, the little fire of filtering residue decocts twice, each 1 hour.Merging filtrate, adding ethanol content in ethanol to filtrate after filtrate is concentrated is 70%, filters, filtrate recycling ethanol, and concentrated, cold preservation, filtration, fine straining, embedding, sterilizing, be namely prepared into injection.
For solving the problems of the technologies described above, present invention also offers the application of above-mentioned Chinese medicine composition in the medicine of the side effect caused for the preparation for the treatment of chemotherapy.
Beneficial effect of the present invention:
Relative to the medicine being used for the treatment of the side effect that chemotherapy causes of the prior art, the treatment of this Chinese medicine composition to the side effect that chemotherapy causes is adopted to have curative effect fast, the advantages such as effective percentage is high, and side effect is little.
Detailed description of the invention
The invention provides a kind of Chinese medicine composition being used for the treatment of the side effect that chemotherapy causes; it comprises: Squama Manis, the Radix Astragali, Radix Curcumae, grape leaf, Radix Ginseng, the Radix Linderae, Rhizoma Polygoni Cuspidati, Calculus Bovis, Thallus Laminariae (Thallus Eckloniae), ear, Radix et Caulis Opuntiae Dillenii, Margarita, Realgar, Stigma Croci, Scolopendra, Herba Solani Lyrati, Radix Trichosanthis, Herba Solani Nigri, Radix Rehmanniae, Herba Verbenae, the Radix Paeoniae Alba, Ganoderma, Rhizoma Sparganii, Fructus Evodiae, Radix Arnebiae (Radix Lithospermi), Herba Andrographis, Colla cornus cervi, Bulbus Tulipae, Daphne giraldii Nitsche, Radix Boehmeriae.
Squama Manis, nature and flavor are salty, cool, and enter liver, stomach warp, function cures mainly, and the routed carbuncle of detumescence, searches wind active, stimulating milk secretion of stimulating the menstrual flow.Control carbuncle skin ulcer kind, anemofrigid-damp arthralgia, amenorrhea, galactostasis.External is stopped blooding.
The Radix Astragali, warm in nature, sweet in the mouth.Function cures mainly: invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting., chronic diarrhea proctoptosis, spontaneous perspiration, edema weak for the deficiency of vital energy, sub-official prolapsus, chronic nephritis proteinuria, diabetes, open sore part disunion of a specified duration.
Radix Curcumae, acrid in the mouth is bitter, cool.Enter the heart, lung, Liver Channel.Function cures mainly: promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.
Compound leaf grape leaf, sweet in the mouth; Micro-puckery; Cool in nature, another name, ' Zhixueling; Sweet tea, effect: hemostasis; Clearing away summer-heat, cures mainly: traumatic hemorrhage; Prevention heatstroke.
Radix Ginseng, sweet and slightly bitter taste, temperature., spleen, lung meridian.Function cures mainly: strongly invigorating primordial QI, promotes the production of body fluid, calm the nerves Gu de-.Control impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, and frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies.
The Radix Linderae, property is pungent, temperature.Enter spleen, lung, kidney, urinary bladder channel.Function cures mainly: pleasant, dissipating depression of QI, cold expelling, pain relieving.Control QI rising in reverse order chest and abdomen swelling and pain, dyspepsia does not disappear, and food is told in regurgitation, colic of cold type, beriberi, frequent micturition.
Rhizoma Polygoni Cuspidati, nature and flavor are bitter, flat.Function cures mainly: dispel the wind, dampness removing, and removing blood stasis with potent drugs stimulates the menstrual flow.Dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis, hundred abdominal masss are gathered, anal fistula hematochezia.Injury from falling down, scalds, malignant boil tinea disease.
Calculus Bovis, property bitter but sweet flavor is cool.Enter the heart, Liver Channel.Function cures mainly: clear away heart-fire, and reduces phlegm, and function of gallbladder promoting is relieving convulsion.Control calentura coma, delirium, epilepsy is gone mad, and infantile convulsion is twitched, ulcerative gingivitis, and larynx swells, aphtha of the mouth and tongue, carbuncle, furunculosis.
Thallus Laminariae (Thallus Eckloniae), nature and flavor are salty, cold.Function cures mainly: softening and eliminating sputum, and diuretic expels the heat-evil.Control goiter tuberculosis, hernia abdominal mass, edema, beriberi.
Herba Hyperici Japonici, nature and flavor, bitter sweet, cool.Function cures mainly: clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating.Control infectious hepatitis, dysentery, infantile convulsion, infantile malnutrition, throat moth, acute appendicitis, furuncle and phyma, venom.
Radix et Caulis Opuntiae Dillenii, nature and flavor are bitter, cold.Enter the heart, lung, stomach three warp.Function cures mainly: promoting flow of QI and blood, heat-clearing and toxic substances removing.Control heart peratodynia, mass in the abdomen, dysentery, hemorrhoidal bleeding, cough, laryngalgia, lung abscess, acute mastitis, furuncle, burn, snakebite.
Margarita, property sweet-salty, cold.Enter the heart, Liver Channel.Function cures mainly: tranquilizing mind, and yin nourishing relieves dizziness, high fever, infantile convulsions, epilepsy, etc., heat clearing away pendant expectorant, removing nebula improving eyesight, removing toxic substances and promoting granulation.Control palpitation with fear, palpitation with a distress feeling, epilepsy, infantile convulsion is twitched, and dysphoria with smothery sensation is quenched one's thirst, sore throat aphtha, and the raw cataracta of order, skin infection does not close up for a long time.
Realgar, acrid in the mouth is bitter, temperature, poisonous.Enter the heart, liver, stomach warp.Function cures mainly: dampness, dispels the wind, parasite killing, removing toxic substances.Control scabies, tinea alba, carbuncle, acute gangrenous stomatitis, herpes zoster, tetanus, snakeworm Eriocheir sinensis hinders, bromhidrosis, ecthyma, asthma, sore throat, infantile convulsion, hemorrhoid complicated by anal fistula.
Stigma Croci, nature and flavor, sweet, flat.Enter the heart, Liver Channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens.Control troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, and spit blood, typhoid fever is gone mad, and frightened fear in a trance, women's amenorrhea, postnatal blood stasis is suffered from abdominal pain, tumbling and swelling.
Scolopendra, acrid in the mouth, temperature, poisonous.Enter Liver Channel.Function cures mainly: dispel the wind, arresting convulsion, counteracting toxic substances, eliminating stagnation.Control apoplexy, infantile convulsion, tetanus, pertussis, scrofula, tuberculosis, hundred buildup blocks, sore swollen toxin, tinea corporis, bald in vain, anal fistula, scalds.
Herba Solani Lyrati, cold in nature, sweet in the mouth; Slightly poisonous.Function cures mainly: heat-clearing and toxic substances removing, expelling wind and removing dampness, blood stasis dispelling.For jaundice due to damp-heat, headache due to pathogenic wind-heat, leukorrhagia, rheumatic arthritis.
Radix Trichosanthis, sweet in the mouth picric acid is cool.Enter lung, stomach warp.Function cures mainly: promote the production of body fluid, and quenches the thirst, and pathogenic fire reducing is moisturized, evacuation of pus, detumescence.Control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.
Herba Solani Nigri, bitter in the mouth, cold.Function cures mainly: heat clearing away, and removing toxic substances, invigorates blood circulation, detumescence.Control furuncle, carbuncle, erysipelas, osteopatia sprain, chronic tracheitis, acute nephritis.For sore and toxic, skin eczema, dysuria, senile chronic tracheitis, leukorrhagia, prostatitis, dysentery.
Herba Verbenae, bitter in the mouth is cool. enter liver, spleen channel.Function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, inducing diuresis to remove edema.Control fever caused by exogenous pathogens, jaundice due to damp-heat, edema, dysentery, malaria, diphtheria, sore throat, gonorrhea, amenorrhea, hundred abdominal masss, carbuncle sore tumefacting virus, ulcerative gingivitis.
Radix Rehmanniae, sweet-bitter flavor, cold.Enter the heart, liver, kidney channel.Function cures mainly: heat clearing away, and removing heat from blood promotes the production of body fluid.Control epidemic febrile disease impairment of YIN, large hot excessive thirst, crimson tongue, coma, macule, spit blood, epistaxis, asthenia hectic fever due to YIN-deficiency, hemoptysis, quenches one's thirst, constipation, metrorrhagia.
The Radix Paeoniae Alba, bitter in the mouth acid, cool.Enter liver, spleen channel.Function cures mainly: nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
Ganoderma, warm in nature, lightly seasoned.Function cures mainly: strengthening by means of tonics.For brain-strengthening, antiinflammatory, diuresis, kidney tonifying.
Rhizoma Sparganii, bitter in the mouth is pungent, flat.Enter liver.Spleen channel.Function cures mainly: removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving.Control hundred abdominal masss to gather, coagulation of QI-blood, trusted subordinate's pain, the lower swollen pain of the side of body, amenorrhea, postnatal blood stasis is suffered from abdominal pain, traumatic injury.Skin ulcer swells hard.
Fructus Evodiae, acrid in the mouth is bitter, temperature, poisonous.Enter liver, stomach warp.Function cures mainly: warming middle-JIAO, and pain relieving is regulated the flow of vital energy, dampness, and stopping vomiting is against acid regurgitation, and headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, abdominal pain during menstruation, Diarrhoea, vascular hypertension, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.
Radix Arnebiae (Radix Lithospermi), bitter in the mouth, cold.Enter percardium, Liver Channel.Function cures mainly: removing heat from blood, invigorates blood circulation, heat clearing away, removing toxic substances.Control warm macule, jaundice due to damp-heat, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.
Herba Andrographis, bitter in the mouth, cold in nature, nontoxic.Enter the heart, lung two warp.Function cures mainly: heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.
Colla cornus cervi, sweet-salty, temperature.Enter liver, kidney channel.Function cures mainly: enrich blood, benefit essence.Control deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, uterus cold caused by deficiency, metrorrhagia, leukorrhagia.
Bulbus Tulipae, sweet in the mouth, cold, poisonous.Function cures mainly: eliminating stagnation, blood stasis dispelling.Control laryngopharynx swelling and pain, scrofula, carbuncle, skin ulcer swells, and puerperal, the stasis of blood was stagnant.
Daphne giraldii Nitsche, acrid in the mouth is bitter, temperature, slightly poisonous.Function cures mainly: expelling wind and removing dampness, pain relieving dissipating blood stasis.Dispelling the wind and dampness pathogens arthralgia pain, numb limbs and tense tendons, headache, stomachache, traumatic injury.
Radix Boehmeriae is sweet in the mouth, cold, nontoxic.Cure mainly: cough asthma due to stagnation of phlegm, urinary obstruction, urine stranguria with blood, pregnant fetal movement, swelling and pain of anus, proctoptosis is not received, carbuncle on the back from the beginning of, erysipelas, knife injury is lost.
Further preferably, the Chinese medicine composition of the side effect that described chemotherapy causes only is made up of said components.
Wherein, the ratio of weight and number of various component can be preferably: Squama Manis 15-40 weight portion, Radix Astragali 10-40 weight portion, Radix Curcumae 5-10 weight portion, grape leaf 5-20 weight portion, Radix Ginseng 5-15 weight portion, Radix Linderae 10-20 weight portion, Rhizoma Polygoni Cuspidati 10-15 weight portion, Calculus Bovis 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-30 weight portion, ground ear 10-25 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Margarita 10-15 weight portion, Realgar 5-10 weight portion, Stigma Croci 10-15 weight portion, Scolopendra 10-12 weight portion, Herba Solani Lyrati 10-15 weight portion, Radix Trichosanthis 5-10 weight portion, Herba Solani Nigri 5-10 weight portion, Radix Rehmanniae 15-25 weight portion, Herba Verbenae 10-15 weight portion, Radix Paeoniae Alba 10-25 weight portion, Ganoderma 10-15 weight portion, Rhizoma Sparganii 10-25 weight portion, Fructus Evodiae 10-25 weight portion, Radix Arnebiae (Radix Lithospermi) 10-15 weight portion, Herba Andrographis 10-15 weight portion, Colla cornus cervi 10-25 weight portion, Bulbus Tulipae 10-15 weight portion, Daphne giraldii Nitsche 10-15 weight portion, Radix Boehmeriae 10-15 weight portion.
Further, the ratio of weight and number of various component also can be preferably: Squama Manis 20-25 weight portion, Radix Astragali 20-30 weight portion, Radix Curcumae 5-8 weight portion, grape leaf 10-20 weight portion, Radix Ginseng 5-10 weight portion, Radix Linderae 10-15 weight portion, Rhizoma Polygoni Cuspidati 10-15 weight portion, Calculus Bovis 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-30 weight portion, ground ear 10-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Margarita 10-15 weight portion, Realgar 5-10 weight portion, Stigma Croci 10-15 weight portion, Scolopendra 10-12 weight portion, Herba Solani Lyrati 10-12 weight portion, Radix Trichosanthis 5-10 weight portion, Herba Solani Nigri 5-10 weight portion, Radix Rehmanniae 15-20 weight portion, Herba Verbenae 10-15 weight portion, Radix Paeoniae Alba 10-15 weight portion, Ganoderma 10-15 weight portion, Rhizoma Sparganii 10-15 weight portion, Fructus Evodiae 10-15 weight portion, Radix Arnebiae (Radix Lithospermi) 10-15 weight portion, Herba Andrographis 10-15 weight portion, Colla cornus cervi 10-15 weight portion, Bulbus Tulipae 10-15 weight portion, Daphne giraldii Nitsche 10-15 weight portion, Radix Boehmeriae 10-15 weight portion.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
The preparation of embodiment 1 traditional Chinese medicine particle 1 of the present invention
By Squama Manis 20g, Radix Astragali 20g, Radix Curcumae 5g, grape leaf 10g, Radix Ginseng 5g, Radix Linderae 10g, Rhizoma Polygoni Cuspidati 10g, Calculus Bovis 10g, Thallus Laminariae (Thallus Eckloniae) 10g, ear 10g, Radix et Caulis Opuntiae Dillenii 10g, Margarita 10g, Realgar 5g, Stigma Croci 10g, Scolopendra 10g, Herba Solani Lyrati 10g, Radix Trichosanthis g, Herba Solani Nigri 5g, Radix Rehmanniae 15g, Herba Verbenae 10g, Radix Paeoniae Alba 10g, Ganoderma 10g, Rhizoma Sparganii 10g, Fructus Evodiae 10g, Radix Arnebiae (Radix Lithospermi) g, Herba Andrographis 10g, Colla cornus cervi 10g, Bulbus Tulipae 10g, Daphne giraldii Nitsche 10g, Radix Boehmeriae 10g.Mix and pulverize; Add the water relative to mixture quality 2000ml, carry out decoction process 2 hours, decoction liquor is filtered, concentration, obtaining the mastic removing moisture, is the ethanol of 65% ~ 75% by the determining alcohol adding 2000ml in the mastic of acquisition, carry out stirring 30 minutes, cold preservation 1.5 hours at 0 ~ 4 DEG C, filter, decompression recycling ethanol, add appropriate medicinal dextrin mix homogeneously, granulate, dry, be ground into 100 object powder, make granule (every 1g is equivalent to crude drug in whole 2g).
The preparation of embodiment 2 traditional Chinese medicine particle 2 of the present invention
Squama Manis 25g, Radix Astragali 30g, Radix Curcumae 8g, grape leaf 20g, Radix Ginseng 10g, Radix Linderae 15g, Rhizoma Polygoni Cuspidati 15g, Calculus Bovis 15g, Thallus Laminariae (Thallus Eckloniae) 30g, ear 15g, Radix et Caulis Opuntiae Dillenii 15g, Margarita 15g, Realgar 10g, Stigma Croci 15g, Scolopendra 12g, Herba Solani Lyrati 12g, Radix Trichosanthis 10g, Herba Solani Nigri 10g, Radix Rehmanniae 20g, Herba Verbenae 15g, Radix Paeoniae Alba 15g, Ganoderma 15g, Rhizoma Sparganii 15g, Fructus Evodiae 15g, Radix Arnebiae (Radix Lithospermi) 15g, Herba Andrographis 15g, Colla cornus cervi 15g, Bulbus Tulipae 15g, Daphne giraldii Nitsche 15g, Radix Boehmeriae 15g.Mix and pulverize; Add the water relative to mixture quality 1500ml, carry out decoction process 2 hours, decoction liquor is filtered, concentration, obtaining the mastic removing moisture, is the ethanol of 65% ~ 75% by the determining alcohol adding 2000ml in the mastic of acquisition, carry out stirring 30 minutes, cold preservation 1.5 hours at 0 ~ 4 DEG C, filter, decompression recycling ethanol, add appropriate medicinal dextrin mix homogeneously, granulate, dry, be ground into 100 object powder, make granule (every 1g is equivalent to crude drug in whole 2g).
The preparation of embodiment 3 Chinese medicine composition composition injection of the present invention
Squama Manis 22g, Radix Astragali 25g, Radix Curcumae 5g, grape leaf 15g, Radix Ginseng 5g, Radix Linderae 10g, Rhizoma Polygoni Cuspidati 12g, Calculus Bovis 10g, Thallus Laminariae (Thallus Eckloniae) 10g, ear 10g, Radix et Caulis Opuntiae Dillenii 10g, Margarita 10g, Realgar 6g, Stigma Croci 12g, Scolopendra 10g, Herba Solani Lyrati 11g, Radix Trichosanthis 7g, Herba Solani Nigri 8g, Radix Rehmanniae 15g, Herba Verbenae 10g, Radix Paeoniae Alba 12g, Ganoderma 10g, Rhizoma Sparganii 10g, Fructus Evodiae 12g, Radix Arnebiae (Radix Lithospermi) 10g, Herba Andrographis 10g, Colla cornus cervi 13g, Bulbus Tulipae 10g, Daphne giraldii Nitsche 14g, Radix Boehmeriae 10g.Mix and pulverize; After medical material being soaked 2 hours with 3500 water, then decoct to boiling with fire, then decoct 30 minutes with little fire, filter, the little fire of filtering residue decocts twice, each 1 hour.Merging filtrate, adding ethanol content in ethanol to filtrate after filtrate is concentrated is 70%, and filter, filtrate recycling ethanol, be concentrated into every 1ml and be equivalent to crude drug in whole 1g, cold preservation, filtration, fine straining, embedding, sterilizing, be namely prepared into injection.
Embodiment 4 toxicity test
Acute toxicity test
(1) test prepares
A, select Kunming white mice 60, weight is 18-22g (each 30 of male and female)
The process of B, test specimen: get 30g traditional Chinese medicine particle 1 of the present invention, add distilled water 50ml, forming content through grinding, to be that 600mg/ml starches entirely for subsequent use.
(2) oral medication: get Kunming white mice 30 (each 15 of male and female), weight is 18-22g/, every white mice gives sample equal serosity 0.5ml gavage, give altogether twice (interval time is 4 hours), accumulated dose is 1ml, observes 10 days, all healthy existence of white mice, without any toxicity, compare zero difference through anatomic observation hemogram, liver function, each organs and tissues morphology finding with matched group.
(3) injection: get Kunming white mice 30 (each 15 of male and female), weight is 18-22g/, every white mice gives Chinese medicine composition composition injection 0.25ml of the present invention intramuscular injection, give altogether twice (interval time is 4 hours), accumulated dose is 0.5ml.Observe 10 days, all healthy existence of white mice, without any toxicity, compares zero difference through anatomic observation hemogram, liver function, each organs and tissues morphology finding with matched group.
2, accumulation toxicity test
(1) test prepares
A, select rat 6-8 week age 30 (each 15 of male and female);
The process of B, test specimen: get 30g traditional Chinese medicine particle 1 of the present invention, add distilled water 50ml, through grinding to form screened stock, can add the right Sodium Tvlose suspending of 1%, and making content is that the homogenate of 600mg/ml is for subsequent use.
(2) oral medication: get rat 30 (each 15 of male and female), divide three dosage groups, three groups are divided into by the rat of random selecting, often organize 10, (each 5 of male and female), give the sample homogenate gavage of every rat every day 0.4ml, 0.25ml, 0.1ml respectively, observe 30 days, the all healthy existence of rat, without any toxicity, zero difference is compared with matched group, without savings in rat body through anatomic observation hemogram, liver function, each organs and tissues form finding.
The above results illustrates: pharmaceutical preparation of the present invention is safe to the medicine for human clinical, and it is nontoxic, have no side effect, without savings.
The concrete clinical experiment of embodiment 5
This organizes 72 routine patients, is inpatient cases, is diagnosed as malignant tumor through cytology, whole body muscle power scoring (KPS scoring) > 70 points, estimate > June life cycle, routine blood test, Liver and kidney merit, cardiac function are all normal, avoid without obvious chemotherapy.Be divided into two groups at random: observation group 36 example, just control 24 examples, control 12 examples again, wherein male is 23 examples, and women is 13 examples; Age 34-69 year, 49.8 years old mean age.Matched group 36 example, just controls 20 examples, controls 16 examples again, and wherein male is 20 examples, and women is 16 examples; Age 35-71 year, 46.9 years old mean age.The sex of two groups, age, histological type, previously diagnosis and treatment situation and KPS scoring are through statistical procedures (all applying statistic software SPSS 16.0), and there was no significant difference, has comparability.
Two groups of concrete conditions are as following table:
Therapeutic Method: pulmonary carcinoma (be all non-small cell patient, comprise two types: adenocarcinoma, scale cancer) patient, adenocarcinoma patient adopts pemetrexed disodium (Pem) 500mg/m
2intravenous drip the 1st day, cisplatin (DDP) 25mg/m
2intravenous drip 1-3 days.Every 3 weeks repeat once.Scale cancer patient applies gemcitabine (GEM) 1000mg/m
2intravenous drip the 1st, 8 days, cisplatin (DDP) 25mg/m
2intravenous drip 1-3 days.Every 3 weeks repeat.Breast carcinoma (being postoperative adjuvant therapy) adopts CAF scheme: cyclophosphamide (CTX) 500mg/m
2intravenous drip the 1st day, amycin (ADM) 50mg/m
2intravenous drip the 1st day, fluorouracil (5-FU) 500mg/m
2intravenous drip the 1st, 8 days, every 3 weeks repeat.Colon cancer and gastric cancer adopt OLF scheme: oxaliplatin (L-OHP) 85mg/m
2intravenous drip the 1st day, calcium folinate (CF) 200mg/m
2intravenous drip 1-5 days, fluorouracil (5-FU) 350mg/m
2intravenous drip 1-5 days, every 3 weeks repeat.The esophageal carcinoma adopts PF scheme: cisplatin (DDP) 20mg/m
2intravenous drip 1-5 days, calcium folinate (CF) 200mg/m
2intravenous drip 1-5 days, fluorouracil (5-FU) 350mg/m
2intravenous drip 1-5 days, every 3 weeks repeat.Two groups of equal all such scheme combined chemotherapies of patient, and conventional application 5-hydroxytryptamine receptor antagonist emesis, observation group is oral Chinese medicine treatment (traditional Chinese medicine particle 2 after chemotherapy, 0.1g/kg), carry out with chemotherapy simultaneously, be used in conjunction 14 days, stop 7 days, carry out the 2nd oral medication when the 2nd the cycle, chemotherapy started, apply 2 cycles more than.Above patient is all in chemotherapy 2-3 cycle post-evaluation curative effect.
Observation index: short term effect is with reference to RECIST1.0 solid tumor the standard of curative effect evaluation; Toxic and side effects is according to WHO standard, and the change of main detection gastrointestinal symptom, routine blood test, hepatic and renal function change.Result is as following table:
Recent effective percentage:
Therapeutic outcome: short term effect: observation group's focus complete incidence graph and partial rcsponse be totally 24 examples, and effective percentage is 66.7%, matched group is 22 examples, and effective percentage is 61.1%, both no difference of science of statistics.(P＞0.05)
The toxic and side effects incidence rate of chemotherapy: the toxic and side effects incidence rate of two groups sees the following form:
The incidence rate of observation group's Nausea and vomiting, leukopenia, liver function damage is starkly lower than matched group (P < 0.05), the incidence rate of stomatitis and diarrhoea is also lower than matched group, but no difference of science of statistics (P > 0.05).Both kidney merit damages are all rare, no significant difference (P > 0.05).
Therefore medicine is in the malignant tumor chemotherapies such as digestive system tumor, respiratory system tumor, breast carcinoma, can play the effect of auxiliary treatment, reduces chemotherapeutic period untoward reaction, effect of tonifying speen and tonifying kidney.
To improve according to other of further embodiment of the present invention and modification is feasible according to above-mentioned instruction.The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.Thus, will be understood that, within the scope of the appended claims, the present invention can the mode except specifically describing herein implement.
Claims (3)
1. be used for the treatment of a Chinese medicine composition for the side effect that chemotherapy causes, it is characterized in that, consist of the following composition: Squama Manis, the Radix Astragali, Radix Curcumae, grape leaf, Radix Ginseng, the Radix Linderae, Rhizoma Polygoni Cuspidati, Calculus Bovis, Thallus Laminariae (Thallus Eckloniae), ground ear, Radix et Caulis Opuntiae Dillenii, Margarita, Realgar, Stigma Croci, Scolopendra, Herba Solani Lyrati, Radix Trichosanthis, Herba Solani Nigri, Radix Rehmanniae, Herba Verbenae, the Radix Paeoniae Alba, Ganoderma, Rhizoma Sparganii, Fructus Evodiae, Radix Arnebiae (Radix Lithospermi), Herba Andrographis, Colla cornus cervi, Bulbus Tulipae, Daphne giraldii Nitsche, Radix Boehmeriae, wherein, Chinese medicine composition comprises Squama Manis 10-40 weight portion, Radix Astragali 10-40 weight portion, Radix Curcumae 5-10 weight portion, grape leaf 5-25 weight portion, Radix Ginseng 5-20 weight portion, Radix Linderae 10-20 weight portion, Rhizoma Polygoni Cuspidati 10-20 weight portion, Calculus Bovis 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-30 weight portion, ground ear 10-25 weight portion, Radix et Caulis Opuntiae Dillenii 10-20 weight portion, Margarita 10-15 weight portion, Realgar 5-10 weight portion, Stigma Croci 10-20 weight portion, Scolopendra 10-15 weight portion, Herba Solani Lyrati 10-15 weight portion, Radix Trichosanthis 5-10 weight portion, Herba Solani Nigri 5-10 weight portion, Radix Rehmanniae 10-25 weight portion, Herba Verbenae 10-15 weight portion, Radix Paeoniae Alba 10-25 weight portion, Ganoderma 10-25 weight portion, Rhizoma Sparganii 10-25 weight portion, Fructus Evodiae 10-25 weight portion, Radix Arnebiae (Radix Lithospermi) 10-20 weight portion, Herba Andrographis 10-20 weight portion, Colla cornus cervi 10-25 weight portion, Bulbus Tulipae 10-15 weight portion, Daphne giraldii Nitsche 10-15 weight portion, Radix Boehmeriae 10-15 weight portion.
2. Chinese medicine composition as claimed in claim 1, wherein, Chinese medicine composition comprises Squama Manis 15-40 weight portion, Radix Astragali 10-40 weight portion, Radix Curcumae 5-10 weight portion, grape leaf 5-20 weight portion, Radix Ginseng 5-15 weight portion, Radix Linderae 10-20 weight portion, Rhizoma Polygoni Cuspidati 10-15 weight portion, Calculus Bovis 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-30 weight portion, ground ear 10-25 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Margarita 10-15 weight portion, Realgar 5-10 weight portion, Stigma Croci 10-15 weight portion, Scolopendra 10-12 weight portion, Herba Solani Lyrati 10-15 weight portion, Radix Trichosanthis 5-10 weight portion, Herba Solani Nigri 5-10 weight portion, Radix Rehmanniae 15-25 weight portion, Herba Verbenae 10-15 weight portion, Radix Paeoniae Alba 10-25 weight portion, Ganoderma 10-15 weight portion, Rhizoma Sparganii 10-25 weight portion, Fructus Evodiae 10-25 weight portion, Radix Arnebiae (Radix Lithospermi) 10-15 weight portion, Herba Andrographis 10-15 weight portion, Colla cornus cervi 10-25 weight portion, Bulbus Tulipae 10-15 weight portion, Daphne giraldii Nitsche 10-15 weight portion, Radix Boehmeriae 10-15 weight portion.
3. Chinese medicine composition as claimed in claim 1, wherein, Chinese medicine composition comprises Squama Manis 20-25 weight portion, Radix Astragali 20-30 weight portion, Radix Curcumae 5-8 weight portion, grape leaf 10-20 weight portion, Radix Ginseng 5-10 weight portion, Radix Linderae 10-15 weight portion, Rhizoma Polygoni Cuspidati 10-15 weight portion, Calculus Bovis 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-30 weight portion, ground ear 10-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Margarita 10-15 weight portion, Realgar 5-10 weight portion, Stigma Croci 10-15 weight portion, Scolopendra 10-12 weight portion, Herba Solani Lyrati 10-12 weight portion, Radix Trichosanthis 5-10 weight portion, Herba Solani Nigri 5-10 weight portion, Radix Rehmanniae 15-20 weight portion, Herba Verbenae 10-15 weight portion, Radix Paeoniae Alba 10-15 weight portion, Ganoderma 10-15 weight portion, Rhizoma Sparganii 10-15 weight portion, Fructus Evodiae 10-15 weight portion, Radix Arnebiae (Radix Lithospermi) 10-15 weight portion, Herba Andrographis 10-15 weight portion, Colla cornus cervi 10-15 weight portion, Bulbus Tulipae 10-15 weight portion, Daphne giraldii Nitsche 10-15 weight portion, Radix Boehmeriae 10-15 weight portion.
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