CN105327327A - Medicine for treating acute cholecystitis and preparing method thereof - Google Patents

Abstract

The invention discloses a medicine for treating acute cholecystitis and a preparing method thereof. The medicine is mainly prepared from honeysuckle, curcuma, phaseolus calcaratus, artemisia capillaries, scutellaria baicalensis, scandent schefflera stems and leaves, lysimachia christinae hance, liquorice, radix paeoniae alba, American ginseng, pinellia ternata, polygonum cuspidatum, lalang grass rhizome, ricepaper pith, radix gentianae, fructus aurantii, szechwan Chinaberry fruit, bunge cherry seeds, rhizoma atractylodis macrocephalae, corydalis tuber, patrinia scaniosaefolia, paeonia suffruticosa, endothelium corneum gigeriae galli, fructus forsythiae, peach kernels, rhizoma zingiberis and rhizoma anemarrhenae which are matched by weight. The medicine can harmonize the exterior and interior, soothe liver-gallbladder, nourish blood and liver, relieve the middle-warmer and stop pain, and clear heat and promote diuresis, and can become effective quickly and has a good curative effect when used for treating acute cholecystitis, and relapse is avoided.

Description

A kind of medicine for the treatment of acute cholecystitis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of acute cholecystitis and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Acute cholecystitis is because gallbladder cavity pressure raises, make gallbladder wall and mucosa pressurized ischemia, phospholipase acts on the lecithin in bile, produces LYSOLECITHIN SUNLECITHIN A and lodges in by escherichia coli, Klebsiella, streptococcus, staphylococcus etc. the gallbladder disease caused in gallbladder.The traditional Chinese medical science then thinks acute cholecystitis and stagnation of QI due to depression of the liver, and dampness-heat in the liver and gallbladder, accumulates in scorchingly hot, and deficiecny of liver-YIN is relevant.Because western medicine side effect is large, therefore there is great demand to the Chinese medicine of effectively treating acute cholecystitis in people, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment acute cholecystitis, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment acute cholecystitis.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Flos Lonicerae, Radix Curcumae, Semen Phaseoli, Herba Artemisiae Scopariae, Radix Scutellariae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Lysimachiae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Panacis Quinquefolii, the Rhizoma Pinelliae, Rhizoma Polygoni Cuspidati, Rhizoma Imperatae, Medulla Tetrapanacis, Radix Gentianae, Fructus Aurantii, Fructus Toosendan, Semen Pruni, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Herba Patriniae, Cortex Moutan, Endothelium Corneum Gigeriae Galli, Fructus Forsythiae, Semen Persicae, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Radix Isatidis, Caulis Bambusae In Taenia, Radix Rehmanniae medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat acute cholecystitis.Wherein, Flos Lonicerae is selected to be because its nature and flavor are sweet, cold, enter lung, stomach warp, have heat clearing away, the function of removing toxic substances, control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Radix Curcumae is selected to be because its nature and flavor are worked hard, cool, enter the heart, lung, Liver Channel, have circulation of qi promoting solution with, the function of removing heat from blood removing blood stasis with potent drugs, control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Semen Phaseoli is selected to be because the sweet acid of its nature and flavor, flat, enter the heart, small intestine meridian, have diuretic to dehumidify, and blood evacuation of pus, the function of subduing swelling and detoxicating, harnesses the river swollen, beriberi, jaundice, and dysentery, has blood in stool, carbuncle.Herba Artemisiae Scopariae is selected to be because its nature and flavor toil, cool, enter liver, spleen, urinary bladder channel, have the function of clearing away heat-damp and promoting diuresis, control jaundice due to damp-heat, dysuria, pruritus due to wind pathogen skin ulcer scabies.Select Radix Scutellariae to be because its nature and flavor bitter cold, enter cardiopulmonary, gallbladder, large intestine channel, have removing the relative excess fire, except damp and hot, the function of arresting bleeding and miscarriage prevention, controls high fever excessive thirst, cough due to lung-heat.Select Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) to be because its property mildly bitter flavor, temperature, has expelling wind and removing dampness, the function of promoting blood circulation and stopping pain, dispelling the wind and dampness pathogens arthralgia pain, stomachache, injury and bone fracture, traumatic hemorrhage.Herba Lysimachiae is selected to be because its nature and flavor toil, cool, there is heat clearing away, diuresis, antitussive, detumescence, the function of removing toxic substances, subcutaneous ulcer of harnessing the Yellow River, edema, vesical calculus, malaria, lung abscess, cough, spit blood, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, infantile malnutrition ， Jing Epilepsy, carbuncle, skin ulcer tinea, eczema.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Radix Panacis Quinquefolii is selected to be that cool, enter the heart, lung, kidney three warp, useful lung yin, clear asthenic fire, the function of promoting the production of body fluid to quench thirst, control deficiency of the lung chronic cough, lose blood, dry throat and mouth, deficiency-heat is tired of tired because its property sweet and slightly bitter taste.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness, outer subduing inflammation.Select Rhizoma Polygoni Cuspidati to be because its nature and flavor are bitter, flat, dispel the wind, dampness removing, removing blood stasis with potent drugs, the function of stimulating the menstrual flow, dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis ， lumps in the chest and abdomen, anal fistula hematochezia, injury from falling down, scalds, malignant boil tinea disease.Select Rhizoma Imperatae to be sweet because of its nature and flavor, cold, enter lung, stomach, small intestine meridian, have removing heat from blood, hemostasis, heat clearing away, the function of diuresis, controls calentura excessive thirst, spits blood, epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.Medulla Tetrapanacis is selected to be that cool, enter lung, stomach warp, have eliminating the pathogens from the lung, diuresis, the function of lower milk, controls dysuria, gonorrhea, edema, puerpera's galactostasis, blurred vision because its property slightly sweet flavor, nasal obstruction.Select Radix Gentianae to be that cold, enter liver, gallbladder meridian, have eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B because its nature and flavor are bitter, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Fructus Aurantii is selected to be because its nature and flavor toil, cool, enter lung, spleen, large intestine channel, have dispelling the stagnated QI, row expectorant, the function of removing food stagnancy, control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Select Fructus Toosendan to be because its nature and flavor are bitter, cold, poisonous, enter liver, stomach, small intestine meridian, have wet down heat, clearing away liver-fire, pain relieving, the function of parasite killing, controls epigastric pain with cold limbs due to adverseness of heat, hypochondriac pain, colic, abdominal pain due to worm stagnation.Select Semen Pruni to be because its nature and flavor are worked hard sweet, flat, enter spleen, intestine and small intestine warp, have and moisturize, laxation, the therapeutic method to keep the adverse QI flowing downwards, the function of diuretic, controls QI stagnation of the large intestine, dry puckery obstructed, dysuria, extensive abdominal edema, extremity edema, beriberi.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Rhizoma Corydalis is selected to be that temperature, enter liver, stomach warp, invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, the function of pain relieving, controls all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury because its nature and flavor are worked hard.Herba Patriniae is selected to be that flat, enter liver, stomach, large intestine channel, have heat-clearing and toxic substances removing, the function of evacuation of pus removing blood stasis with potent drugs, controls acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain, carbuncle scabies because its nature and flavor are bitter.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle ， Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.Select Endothelium Corneum Gigeriae Galli to be because its nature and flavor are sweet, flat, enter spleen, stomach warp, control stagnant, the function of strengthening the spleen and stomach, control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.Select Fructus Forsythiae to be because its nature and flavor are bitter, cool, enter the heart, liver, gallbladder meridian, have heat clearing away, removing toxic substances, eliminating stagnation, the function of detumescence, controls warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Semen Persicae is selected to be because its property bitter but sweet flavor, flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select Rhizoma Zingiberis to be that heat, enters spleen, stomach, lung meridian because its nature and flavor are pungent, have warming middle-JIAO by cold, the function that recuperating depleted YANG is promoted blood circulation, controls trusted subordinate's cold type of pain, vomits and diarrhoea, cold extremities faint pulse, and cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, and yang deficiency is told, be defeated in battle, hematochezia.The Rhizoma Anemarrhenae is selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Radix Isatidis to be because its nature and flavor are bitter, cold, enter liver, stomach blood system, have heat clearing away, removing toxic substances, the function of removing heat from blood, controls influenza, epidemic encephalitis, encephalitis b, pneumonia, erysipelas, and pyretic toxicity sends out speckle, and coma tells nosebleed, pharyngeal swelling, mumps, acute catarrhal conjunctivitis, skin ulcer rash.Select Caulis Bambusae In Taenia to be because its nature and flavor are sweet, cool, enter stomach, gallbladder meridian, have heat clearing away, removing heat from blood, reduce phlegm, the function of emesis, control dysphoria with smothery sensation vomiting, singultus, expectorant heat syndrome cough is breathed heavily, and spits blood, epistaxis, metrorrhagia, malignant histocytosis, fetal movement ， Jing Epilepsy.Select Radix Rehmanniae to be that cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, the function of promoting the production of body fluid, and controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, and interior-heat is quenched one's thirst because its nature and flavor are sweet, spit blood, epistaxis, sends out speckle dermexanthesis.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight

Flos Lonicerae 10-20 gram, Radix Curcumae 10-20 gram, Semen Phaseoli 5-15 gram, Herba Artemisiae Scopariae 15-25 gram, Radix Scutellariae 10-15 gram, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10-20 gram, Herba Lysimachiae 15-25 gram, Radix Glycyrrhizae 5-10 gram, Radix Paeoniae Alba 10-20 gram, Radix Panacis Quinquefolii 5-15 gram, Rhizoma Pinelliae 10-20 gram, Rhizoma Polygoni Cuspidati 5-15 gram, Rhizoma Imperatae 10-20 gram, Medulla Tetrapanacis 5-15 gram, Radix Gentianae 10-20 gram, Fructus Aurantii 10-20 gram, Fructus Toosendan 5-15 gram, Semen Pruni 7-12 gram, Rhizoma Atractylodis Macrocephalae 10-20 gram, Rhizoma Corydalis 7-12 gram, Herba Patriniae 10-20 gram, Cortex Moutan 10-20 gram, Endothelium Corneum Gigeriae Galli 5-15 gram, Fructus Forsythiae 10-20 gram, Semen Persicae 10-20 gram, Rhizoma Zingiberis 3-9 gram, Rhizoma Anemarrhenae 5-15 gram, Radix Isatidis 10-20 gram, Caulis Bambusae In Taenia 5-15 gram, Radix Rehmanniae 10-20 gram.

Be preferably

Flos Lonicerae 15 grams, Radix Curcumae 15 grams, Semen Phaseoli 10 grams, Herba Artemisiae Scopariae 20 grams, Radix Scutellariae 12 grams, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 15 grams, Herba Lysimachiae 20 grams, 8 grams, Radix Glycyrrhizae, the Radix Paeoniae Alba 15 grams, Radix Panacis Quinquefolii 10 grams, the Rhizoma Pinelliae 15 grams, Rhizoma Polygoni Cuspidati 10 grams, Rhizoma Imperatae 15 grams, Medulla Tetrapanacis 10 grams, Radix Gentianae 15 grams, Fructus Aurantii 15 grams, Fructus Toosendan 10 grams, Semen Pruni 9 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Rhizoma Corydalis 9 grams, Herba Patriniae 15 grams, Cortex Moutan 15 grams, Endothelium Corneum Gigeriae Galli 10 grams, Fructus Forsythiae 15 grams, 15 grams, Semen Persicae, Rhizoma Zingiberis 6 grams, the Rhizoma Anemarrhenae 10 grams, Radix Isatidis 15 grams, Caulis Bambusae In Taenia 10 grams, Radix Rehmanniae 15 grams.

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Flos Lonicerae: sieve removes silt, picks clean impurity;

2, Radix Curcumae: be soaked in water, cleans, pulls solarization out and dry in the air, run through, and section, dries;

3, Semen Phaseoli: get crude drug, removing impurity, the used time smashs to pieces;

4, Herba Artemisiae Scopariae: sieve, picks decontamination, and removing undesirable root, pulverizes, remove spare after sieve;

5, Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;

6, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae): get crude drug, cleans, dries;

7, Herba Lysimachiae: pick clean impurity, sieve dedust bits, dry;

8, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;

9, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;

10, Radix Panacis Quinquefolii: former medicinal clear water spray tide, cover wet cloth, Xia Qiu moistens 2 days, and Winter-Spring moistens 3 days, takes out section, dries;

11, the Rhizoma Pinelliae: pick decontamination, sieve dedust bits;

12, Rhizoma Polygoni Cuspidati: spring and autumn excavates, cutting is dried;

13, Rhizoma Imperatae: pick clean impurity, clean, micro-profit, cutting, dries, clean chip of winnowing with a dustpan;

14, Medulla Tetrapanacis: pick decontamination, section;

15, Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;

16, Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and section, dries;

17, Fructus Toosendan: pick decontamination, cleans, and dries, grating or cleave in two;

18, Semen Pruni: sieve removes spare, wash in a pan clean, pick clean impurity and broken shell, dry, the used time smashs to pieces;

19, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

20, Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

21, Herba Patriniae: get crude drug, removing impurity, with Water spray, slightly dries in the air, and cutting is dry;

22, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;

23, Endothelium Corneum Gigeriae Galli: pick decontamination, rinses and dries;

24, Fructus Forsythiae: pick clean impurity, stranding is opened, except discarding stalk;

25, Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

26, Rhizoma Zingiberis: pick clean impurity, is soaked in water 3-6 hours, pulls out, cuts into slices or dices, dry after moistening;

27, the Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;

28, Radix Isatidis: pick clean impurity, cleans, runs through, and section, dries;

29, Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shakes off ash bits, is kneaded into little group or cutting;

30, Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip.

Two, prepare

1, the Flos Lonicerae after the process of preparing Chinese medicine, Radix Curcumae, Semen Phaseoli, Herba Artemisiae Scopariae, Radix Scutellariae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Lysimachiae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Panacis Quinquefolii, the Rhizoma Pinelliae, Rhizoma Polygoni Cuspidati, Rhizoma Imperatae, Medulla Tetrapanacis, Radix Gentianae, Fructus Aurantii, Fructus Toosendan, Semen Pruni, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Herba Patriniae, Cortex Moutan, Endothelium Corneum Gigeriae Galli, Fructus Forsythiae, Semen Persicae, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Radix Isatidis, Caulis Bambusae In Taenia, Radix Rehmanniae are put into decocting container, add water 8 times amount for the first time, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container;

2, add water the medicinal residues of filtration 6 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;

3, by twice decoction liquor mixing and stirring, 4 doses are divided into take.

In prescription, Herba Artemisiae Scopariae has clearing away heat-damp and promoting diuresis, and the function controlling jaundice due to damp-heat is monarch drug; Radix Bupleuri reconciling superficies and interior, depressed liver-energy dispersing and function of gallbladder promoting, yang invigorating; Fructus Gardeniae has heat clearing away, pathogenic fire purging, removing heat from blood, anti-icteric function, the two is ministerial drug, and three taste medicines play clearing away heat-damp and promoting diuresis, reconciling superficies and interior, depressed liver-energy dispersing and function of gallbladder promoting jointly, yang invigorating, controls the effect of jaundice due to damp-heat, and treatment acute cholecystitis effect is comprehensive, and with clearing away heat-damp and promoting diuresis, depressed liver-energy dispersing and function of gallbladder promoting, yang invigorating is that master can be effected a permanent cure, the Radix Paeoniae Alba has nourishing blood to suppress the hyperactive liver, and in slow, the function of pain relieving is adjuvant drug, and Fructus Toosendan has wet down heat, clearing away liver-fire, the function of pain relieving, for making medicine, is take stopgap measures with all medicines of remainder.

Medicine of the present invention has reconciling superficies and interior, depressed liver-energy dispersing and function of gallbladder promoting, nourishing blood to suppress the hyperactive liver, and pain relieving in slow, the function of clearing away heat-damp and promoting diuresis, is used for the treatment of acute cholecystitis, short treating period, instant effect, non-relapse after healing.

Detailed description of the invention:

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention:

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Taking admixing medical solutions super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, twice daily, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept acute cholecystitis out-patient totally 30 examples for medical treatment.

2, diagnostic criteria

Classical symptom is right hypochondrial region, Nausea and vomiting.There is right hypochondrial region in patient Chang Shouxian, take on back to the right and diffuse, pain is persistence, and paroxysmal is aggravated, and can be attended by Nausea and vomiting.Vomitus is Stomach duodenum content.Later stage performance heating, mostly is low grade fever, and shiver with cold, high heat is not common, early stage many without jaundice, when the concurrent inflammation of bile duct or inflammation cause portal lymph node enlargement, can occur the symptoms such as jaundice.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 7 days, is a course for the treatment of, takes 2 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: acute cholecystitis transference cure, body constitution recovers normal, recovery from illness;

Take a turn for the better: patient's right hypochondrial region, feel sick, the symptom of vomiting alleviates, and heating paresthesia controls, and acute cholecystitis symptom is clearly better, and body constitution is progressively recovered;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy acute cholecystitis patient 33 example of the present invention, effective 26 examples of result, obvious effective rate is 78.79%, and take a turn for the better 5 examples, and improvement rate is 15.15%, and invalid 2 examples, total effective rate is 93.94%.

Claims (3)

1. treat a medicine for acute cholecystitis, it is characterized in that: it is made up of the crude drug in following weight range:

Flos Lonicerae 10-20 gram, Radix Curcumae 10-20 gram, Semen Phaseoli 5-15 gram, Herba Artemisiae Scopariae 15-25 gram, Radix Scutellariae 10-15 gram, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10-20 gram, Herba Lysimachiae 15-25 gram, Radix Glycyrrhizae 5-10 gram, Radix Paeoniae Alba 10-20 gram, Radix Panacis Quinquefolii 5-15 gram, Rhizoma Pinelliae 10-20 gram, Rhizoma Polygoni Cuspidati 5-15 gram, Rhizoma Imperatae 10-20 gram, Medulla Tetrapanacis 5-15 gram, Radix Gentianae 10-20 gram, Fructus Aurantii 10-20 gram, Fructus Toosendan 5-15 gram, Semen Pruni 7-12 gram, Rhizoma Atractylodis Macrocephalae 10-20 gram, Rhizoma Corydalis 7-12 gram, Herba Patriniae 10-20 gram, Cortex Moutan 10-20 gram, Endothelium Corneum Gigeriae Galli 5-15 gram, Fructus Forsythiae 10-20 gram, Semen Persicae 10-20 gram, Rhizoma Zingiberis 3-9 gram, Rhizoma Anemarrhenae 5-15 gram, Radix Isatidis 10-20 gram, Caulis Bambusae In Taenia 5-15 gram, Radix Rehmanniae 10-20 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Flos Lonicerae 15 grams, Radix Curcumae 15 grams, Semen Phaseoli 10 grams, Herba Artemisiae Scopariae 20 grams, Radix Scutellariae 12 grams, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 15 grams, Herba Lysimachiae 20 grams, 8 grams, Radix Glycyrrhizae, the Radix Paeoniae Alba 15 grams, Radix Panacis Quinquefolii 10 grams, the Rhizoma Pinelliae 15 grams, Rhizoma Polygoni Cuspidati 10 grams, Rhizoma Imperatae 15 grams, Medulla Tetrapanacis 10 grams, Radix Gentianae 15 grams, Fructus Aurantii 15 grams, Fructus Toosendan 10 grams, Semen Pruni 9 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Rhizoma Corydalis 9 grams, Herba Patriniae 15 grams, Cortex Moutan 15 grams, Endothelium Corneum Gigeriae Galli 10 grams, Fructus Forsythiae 15 grams, 15 grams, Semen Persicae, Rhizoma Zingiberis 6 grams, the Rhizoma Anemarrhenae 10 grams, Radix Isatidis 15 grams, Caulis Bambusae In Taenia 10 grams, Radix Rehmanniae 15 grams.

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Flos Lonicerae: sieve removes silt, picks clean impurity;

(2) Radix Curcumae: be soaked in water, cleans, pulls solarization out and dry in the air, run through, and section, dries;

(3) Semen Phaseoli: get crude drug, removing impurity, the used time smashs to pieces;

(4) Herba Artemisiae Scopariae: sieve, picks decontamination, and removing undesirable root, pulverizes, remove spare after sieve;

(5) Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;

(6) Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae): get crude drug, cleans, dries;

(7) Herba Lysimachiae: pick clean impurity, sieve dedust bits, dry;

(8) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;

(9) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;

(10) Radix Panacis Quinquefolii: former medicinal clear water spray tide, cover wet cloth, Xia Qiu moistens 2 days, and Winter-Spring moistens 3 days, takes out section, dries;

(11) Rhizoma Pinelliae: pick decontamination, sieve dedust bits;

(12) Rhizoma Polygoni Cuspidati: spring and autumn excavates, cutting, dries;

(13) Rhizoma Imperatae: pick clean impurity, clean, micro-profit, cutting, dries, clean chip of winnowing with a dustpan;

(14) Medulla Tetrapanacis: pick decontamination, section;

(15) Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;

(16) Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and section, dries;

(17) Fructus Toosendan: pick decontamination, cleans, and dries, grating or cleave in two;

(18) Semen Pruni: sieve removes spare, wash in a pan clean, pick clean impurity and broken shell, dry, the used time smashs to pieces;

(19) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

(20) Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

(21) Herba Patriniae: get crude drug, removing impurity, with Water spray, slightly dries in the air, and cutting is dry;

(22) Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;

(23) Endothelium Corneum Gigeriae Galli: pick decontamination, rinses and dries;

(24) Fructus Forsythiae: pick clean impurity, stranding is opened, except discarding stalk;

(25) Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

(26) Rhizoma Zingiberis: pick clean impurity, is soaked in water 3-6 hours, pulls out, cuts into slices or dices, dry after moistening;

(27) Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;

(28) Radix Isatidis: pick clean impurity, cleans, runs through, and section, dries;

(29) Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shakes off ash bits, is kneaded into little group or cutting;

(30) Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;

(2) prepare

(1) Flos Lonicerae after the process of preparing Chinese medicine, Radix Curcumae, Semen Phaseoli, Herba Artemisiae Scopariae, Radix Scutellariae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Lysimachiae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Panacis Quinquefolii, the Rhizoma Pinelliae, Rhizoma Polygoni Cuspidati, Rhizoma Imperatae, Medulla Tetrapanacis, Radix Gentianae, Fructus Aurantii, Fructus Toosendan, Semen Pruni, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Herba Patriniae, Cortex Moutan, Endothelium Corneum Gigeriae Galli, Fructus Forsythiae, Semen Persicae, Rhizoma Zingiberis, the Rhizoma Anemarrhenae, Radix Isatidis, Caulis Bambusae In Taenia, Radix Rehmanniae are put into decocting container, add water 8 times amount, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container;

(2) add water the medicinal residues of filtration 6 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;

(3) by twice decoction liquor mixing and stirring, 4 doses are divided into take.