CN101766783A - Traditional Chinese medicine combination for treating cholecystitis and capsule preparation method thereof - Google Patents

Abstract

The invention discloses traditional Chinese medicine combination for treating cholecystitis and a capsule preparation method thereof; the traditional Chinese medicine combination is formed by nineteen Chinese medicinal crop raw materials, that is, tarragon, radix bupleuri, desmodium, rhubarb, radix curcumae, radix paeoniae alba, fructus aurantii, costus root, green tangerine orange peel, rhizoma cyperi, kumquat leaves, tuckahoe, liquorice, gardenia, plantain seed, bamboo shavings, rhizoma pinellinae praeparata, szechwan Chinaberry fruit and corydalis tuber; the traditional Chinese medicine combination has the efficiency of clearing liver and choleretic action, promoting qi circulation and relieving pain, is used for acute chronic cholecystitis caused by qi depression to blood stasis and liver and gallbladder damp-heat, hydrocholecystis, gall bladder suppuration accumulation and the other gall bladder diseases.

Description

A kind of Chinese medicine drug regimen and capsule preparation method thereof thereof that is used for the treatment of cholecystitis

Technical field

The invention belongs to tcm field, be specifically related to a kind of Chinese medicine drug regimen and capsule preparation method thereof thereof that is used for the treatment of cholecystitis.

Background technology

Cholecystitis is commonly encountered diseases, frequently-occurring disease in clinical.Clinical manifestation is a right hypochondrial region, often after heavy meal, shows effect, and sharp ache, and intermittence increases the weight of. and shoulder diffuses to the right sometimes.And often with heating, nausea and vomiting.Abdominal distention and little diet, even can have jaundice to take place.Cholecystitis belongs to the hypochondriac pain category in the traditional Chinese medical science.On the books in " interior warp ", and spell out, the generation of hypochondriac pain mainly is because the liver and gall pathological changes.Says as " Ling Shu Miraculous Pivot or Divine Axis five pathogenic factors " piece of writing: " evil in liver, then in two sides of body bitterly." " element is asked an opinion piece of writing when hiding the gas method " say: " liver patient, bilateral hypochondriac pain referring to the lateral-lower abdomen.”

The sick position of cholecystitis relates to spleen, nephropathy because of a minute pent-up impairing the liver mainly at liver, gallbladder, stops in the phlegm retention, and blood stasis is stagnated, caused by liver and kidney deficiency etc.And the relation between the liver and gall is very close.Liver and gallbladder be the exterior and the interior mutually, the gallbladder being attached to the liver, have passages through which vital energy circulates each other network belong to.Bile derives from gas after the liver, and full catharsis function by liver can normally be drained and bring into play to bile, if the catharsis malfunction of liver will influence biliary secretion and drainage; Otherwise,, also can influence the catharsis of liver if bile excretion is not smooth.Therefore, liver and gallbladder are closely related on physiological and pathological, and hepatopathy often influences gallbladder, and gallbladder disease is ordinary wave and liver also, and finally then liver and gall are sick together.As dampness-heat in the liver and gallbladder etc.Therefore, the treatment of cholecystitis should be started with from liver,spleen,kidney, adopts depressed liver-energy dispersing and QI regulating, invigorating the spleen to clear away damp pathogen, eliminating blood stasis and smoothing collaterals, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs such as nourishing the liver and kidney.

Preparation of the present invention has the effect of liver heat removing function of gallbladder promoting, promoting the circulation of QI to relieve pain based on Chinese medical theory, is used for gallbladder diseases such as acute and chronic cholecystitis that qi depression to blood stasis, dampness-heat in the liver and gallbladder cause, gallbladder hydrops, gallbladder pus collection.

Summary of the invention

The invention provides a kind of Chinese medicine drug regimen and capsule preparation method thereof thereof that is used for the treatment of cholecystitis, purpose is to select for extensive patients provides new medication, makes things convenient for patient treatment.

The present invention is achieved by the following technical solutions:

A kind of Chinese medicine drug regimen that is used for the treatment of cholecystitis, it is that raw material is made by following parts by weight of Chinese traditional medicine material:

3～15 parts of 10～45 parts of Radix Et Rhizoma Rhei of 5～25 portions of Herba Lysimachiaes of 5～20 parts of Radix Bupleuri of Herba Artemisiae Scopariae

3～20 parts of 5～35 portions of Radix Aucklandiae (Radix Vladimiriae) of 5～45 parts of Fructus Aurantiis of 5～35 portions of Radix Paeoniae Albas of Radix Curcumae

4～25 parts in 5～35 parts of Poria of 5～45 parts of Fructus Fortunellae Margaritae leaves of 5～35 portions of Rhizoma Cyperis of Pericarpium Citri Reticulatae Viride

10～35 parts of 5～36 parts of Caulis Bambusae In Taenia of 5～45 portions of Semen Plantaginiss of 4～30 portions of Fructus Gardeniaes of Radix Glycyrrhizae

5～25 parts of 5～30 parts of Rhizoma Corydalis of 1～15 part of Fructus Toosendan of Rhizoma Pinelliae Preparatum

And the weight portion proportioning of described each Chinese crude drug raw material is:

7 parts of 25 parts of Radix Et Rhizoma Rhei of 12 portions of Herba Lysimachiaes of 10 parts of Radix Bupleuri of Herba Artemisiae Scopariae

7 parts of 13 portions of Radix Aucklandiae (Radix Vladimiriae) of 10 parts of Fructus Aurantiis of 15 portions of Radix Paeoniae Albas of Radix Curcumae

10 parts in 15 parts of Poria of 20 parts of Fructus Fortunellae Margaritae leaves of 15 portions of Rhizoma Cyperis of Pericarpium Citri Reticulatae Viride

20 parts of 12 parts of Caulis Bambusae In Taenia of 15 portions of Semen Plantaginiss of 10 portions of Fructus Gardeniaes of Radix Glycyrrhizae

8 parts of 12 parts of Rhizoma Corydalis of 5 parts of Fructus Toosendans of Rhizoma Pinelliae Preparatum

Described preparation is a capsule.

Described adjuvant includes but not limited to one or more in starch, dextrin, lactose, mannitol, the soluble starch etc.

The preparation method of this drug regimen is:

(1) get Radix Bupleuri, Radix Aucklandiae (Radix Vladimiriae), Fructus Fortunellae Margaritae leaf, Herba Artemisiae Scopariae and be ground into coarse powder, with 20～70% ethanol extractions 2～5 times, each 6～10 times of amounts 2～5 hours, filter, medicinal residues are standby, merging filtrate, reclaim ethanol, be concentrated into the thick paste of relative density 1.05～1.30 (30～80 ℃);

(2) get 15 flavor medicated powder such as Herba Lysimachiae and be broken into coarse powder and merge, decoct with water 2～5 times with above-mentioned medicinal residues, each 6～10 times of amounts 1～3 hour, filtration, collecting decoction is concentrated into the thick paste of relative density 1.05～1.30 (30～80 ℃);

(3) above-mentioned steps (1) (2) gained thick paste is mixed, drying is pulverized, and adds appropriate amount of auxiliary materials, sieves, and granulates, and incapsulates, and makes capsule, promptly.

For beneficial effect of the present invention better is described, we have carried out following experimental study:

Adopt following principal agent for square substantially:

Herba Artemisiae Scopariae 10g Radix Bupleuri 12g Herba Lysimachiae 25g Radix Et Rhizoma Rhei 7g

Radix Curcumae 15g Radix Paeoniae Alba 10g Fructus Aurantii 13g Radix Aucklandiae (Radix Vladimiriae) 7g

Pericarpium Citri Reticulatae Viride 15g Rhizoma Cyperi 20g Fructus Fortunellae Margaritae leaf 15g Poria 10g

Radix Glycyrrhizae 10g Fructus Gardeniae 15g Semen Plantaginis 12g Caulis Bambusae In Taenia 20g

Rhizoma Pinelliae Preparatum 5g Fructus Toosendan 12g Rhizoma Corydalis 8g

One, pharmacodynamic experiment

1 experiment material

This preparation is developed voluntarily by my company, and the water solution dilution is to 2000gL ^-1Standby.XIAOYAN LIDAN PIAN is produced by Shantou, Guangdong three factories of pharmaceutical factory, and lot number 061007 is prepared into aqueous suspension (every milliliter contains crude drug 1g).Animal housing provide (the moving word 14-005 of medical experiment animal quality certification doctor, 14-006).The moving word 14-023 of medical experiment animal environment facility quality certification doctor.METTLERAE240 ten thousand/electronic balance.

2 methods and result

2.1 to the excretory influence of rat bile

Male rat, body weight (180 ± 20) g divides 4 groups at random, fasting 16h before the experiment.Lumbar injection sodium phenobarbital (100mgkg ^-1) anesthesia, cut open the belly, thin drainage tube is inserted common bile duct, and common bile duct is fixed with drainage tube ligation together.After stablizing 20min, measure bile flow in the 30min, oral administration is then collected and is measured bile flow 1 time every 30min, totally 3 times, the results are shown in Table 1.Preparation of the present invention has significant promotion rat bile secretory action, and the bile flow increment rate is 23.1.

Table 1 gallbladder peace mixture is to the influence of rat bile secretory volume (x ± s)

2.2 mice gallbladder weight is influenced

40 male white mouses, body weight 24～28g divides 4 groups at random, fasting 16h before the administration.30min puts to death after the administration, and the extraction gallbladder is weighed, and calculates and respectively organizes gallbladder weight, the results are shown in Table 2.The result shows that preparation of the present invention can quicken the mice gall bladder emptying.

Table 2 preparation of the present invention is to the influence of mice gallbladder weight

3 discuss

Effect experiment shows that preparation of the present invention can significantly promote the bile secretion of anesthetized rat, and quickens the mice gallbladder to biliary Excretion, has the effect of liver heat removing function of gallbladder promoting.

The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.

The specific embodiment

Embodiment 1: medicament composition capsule agent of the present invention

Herba Artemisiae Scopariae 10g Radix Bupleuri 12g Herba Lysimachiae 25g Radix Et Rhizoma Rhei 7g

Radix Curcumae 15g Radix Paeoniae Alba 10g Fructus Aurantii 13g Radix Aucklandiae (Radix Vladimiriae) 7g

Pericarpium Citri Reticulatae Viride 15g Rhizoma Cyperi 20g Fructus Fortunellae Margaritae leaf 15g Poria 10g

Radix Glycyrrhizae 10g Fructus Gardeniae 15g Semen Plantaginis 12g Caulis Bambusae In Taenia 20g

Rhizoma Pinelliae Preparatum 5g Fructus Toosendan 12g Rhizoma Corydalis 8g

(1) get Radix Bupleuri, Radix Aucklandiae (Radix Vladimiriae), Fructus Fortunellae Margaritae leaf, Herba Artemisiae Scopariae and be ground into coarse powder, with 60% alcohol extraction 2 times, each 8 times of amounts 2.5 hours filter, and medicinal residues are standby, and merging filtrate reclaims ethanol, is concentrated into the thick paste of relative density 1.20 (70 ℃);

(2) get 15 flavor medicated powder such as Herba Lysimachiae and be broken into coarse powder and merge, decoct with water 3 times with above-mentioned medicinal residues, each 10 times of amounts 1.5 hours, filtration, collecting decoction is concentrated into the thick paste of relative density 1.25 (70 ℃);

(3) above-mentioned steps (1) (2) gained thick paste is mixed, drying is pulverized, and adds 20g starch, sieves, and granulates, and makes 140 capsules, promptly.

Embodiment 2: medicament composition capsule agent of the present invention

Herba Artemisiae Scopariae 10g Radix Bupleuri 15g Herba Lysimachiae 20g Radix Et Rhizoma Rhei 10g

Radix Curcumae 20g Radix Paeoniae Alba 25g Fructus Aurantii 25g Radix Aucklandiae (Radix Vladimiriae) 12g

Pericarpium Citri Reticulatae Viride 20g Rhizoma Cyperi 10g Fructus Fortunellae Margaritae leaf 15g Poria 17g

Radix Glycyrrhizae 20g Fructus Gardeniae 25g Semen Plantaginis 9g Caulis Bambusae In Taenia 20g

Rhizoma Pinelliae Preparatum 6g Fructus Toosendan 11g Rhizoma Corydalis 17g

(1) get Radix Bupleuri, Radix Aucklandiae (Radix Vladimiriae), Fructus Fortunellae Margaritae leaf, Herba Artemisiae Scopariae and be ground into coarse powder, with 65% ethanol extraction 2 times, 10 times of amounts are 2.5 hours for the first time; Measured 2 hours for 9 times for the second time, filter, medicinal residues are standby, and merging filtrate reclaims ethanol, is concentrated into the thick paste of relative density 1.20 (60 ℃);

(2) get 15 flavor medicated powder such as Herba Lysimachiae and be broken into coarse powder and merge, decoct with water 2 times with above-mentioned medicinal residues, each 10 times of amounts 1.5 hours, filtration, collecting decoction is concentrated into the thick paste of relative density 1.20 (70 ℃);

(3) above-mentioned steps (1) (2) gained thick paste is mixed, drying is pulverized, and adds dextrin 25g, sieves, and granulates, and makes 160 seed lac wafers, promptly.

Embodiment 3: medicament composition capsule agent of the present invention

Herba Artemisiae Scopariae 7g Radix Bupleuri 10g Herba Lysimachiae 15g Radix Et Rhizoma Rhei 7g

Radix Curcumae 20g Radix Paeoniae Alba 15g Fructus Aurantii 10g Radix Aucklandiae (Radix Vladimiriae) 15g

Pericarpium Citri Reticulatae Viride 20g Rhizoma Cyperi 15g Fructus Fortunellae Margaritae leaf 20g Poria 10g

Radix Glycyrrhizae 15g Fructus Gardeniae 20g Semen Plantaginis 15g Caulis Bambusae In Taenia 17g

Rhizoma Pinelliae Preparatum 6g Fructus Toosendan 7g Rhizoma Corydalis 12g

(1) get Radix Bupleuri, Radix Aucklandiae (Radix Vladimiriae), Fructus Fortunellae Margaritae leaf, Herba Artemisiae Scopariae and be ground into coarse powder, with 55% ethanol extraction 2 times, each 8 times of amounts 2.5 hours filter, and medicinal residues are standby, and merging filtrate reclaims ethanol, is concentrated into the thick paste of relative density 1.20 (75 ℃);

(2) get 15 flavor medicated powder such as Herba Lysimachiae and be broken into coarse powder and merge, decoct with water 2 times with above-mentioned medicinal residues, each 10 times of amounts 1.5 hours, filtration, collecting decoction is concentrated into the thick paste of relative density 1.20 (50 ℃);

(3) above-mentioned steps (1) (2) gained thick paste is mixed, drying is pulverized, and adds 10g starch, sieves, and granulates, and makes 72 seed lac wafers, promptly.

Claims (3)

1. Chinese medicine drug regimen that is used for the treatment of cholecystitis is characterized in that it is made up of by the raw material of Chinese medicine of part following unit of weight:

3～15 parts of 10～45 parts of Radix Et Rhizoma Rhei of 5～25 portions of Herba Lysimachiaes of 5～20 parts of Radix Bupleuri of Herba Artemisiae Scopariae

3～20 parts of 5～35 portions of Radix Aucklandiae (Radix Vladimiriae) of 5～45 parts of Fructus Aurantiis of 5～35 portions of Radix Paeoniae Albas of Radix Curcumae

4～25 parts in 5～35 parts of Poria of 5～45 parts of Fructus Fortunellae Margaritae leaves of 5～35 portions of Rhizoma Cyperis of Pericarpium Citri Reticulatae Viride

10～35 parts of 5～36 parts of Caulis Bambusae In Taenia of 5～45 portions of Semen Plantaginiss of 4～30 portions of Fructus Gardeniaes of Radix Glycyrrhizae

5～25 parts of 5～30 parts of Rhizoma Corydalis of 1～15 part of Fructus Toosendan of Rhizoma Pinelliae Preparatum.

2. a kind of Chinese medicine drug regimen that is used for the treatment of cholecystitis according to claim 1 is characterized in that it is made up of by the raw material of Chinese medicine of part following unit of weight:

7 parts of 25 parts of Radix Et Rhizoma Rhei of 12 portions of Herba Lysimachiaes of 10 parts of Radix Bupleuri of Herba Artemisiae Scopariae

7 parts of 13 portions of Radix Aucklandiae (Radix Vladimiriae) of 10 parts of Fructus Aurantiis of 15 portions of Radix Paeoniae Albas of Radix Curcumae

10 parts in 15 parts of Poria of 20 parts of Fructus Fortunellae Margaritae leaves of 15 portions of Rhizoma Cyperis of Pericarpium Citri Reticulatae Viride

20 parts of 12 parts of Caulis Bambusae In Taenia of 15 portions of Semen Plantaginiss of 10 portions of Fructus Gardeniaes of Radix Glycyrrhizae

8 parts of 12 parts of Rhizoma Corydalis of 5 parts of Fructus Toosendans of Rhizoma Pinelliae Preparatum.

3. according to each described a kind of Chinese medicine drug regimen that is used for the treatment of cholecystitis of claim 1-2, its preparation method is:

(1) get Radix Bupleuri, Radix Aucklandiae (Radix Vladimiriae), Fructus Fortunellae Margaritae leaf, Herba Artemisiae Scopariae and be ground into coarse powder, with 20～70% ethanol extractions 2～5 times, each 6～10 times of amounts 2～5 hours, filter, medicinal residues are standby, merging filtrate, reclaim ethanol, be concentrated into the thick paste of relative density 1.05～1.30 (30～80 ℃);

(2) get 15 flavor medicated powder such as Herba Lysimachiae and be broken into coarse powder and merge, decoct with water 2～5 times with above-mentioned medicinal residues, each 6～10 times of amounts 1～3 hour, filtration, collecting decoction is concentrated into the thick paste of relative density 1.05～1.30 (30～80 ℃);

(3) above-mentioned steps (1) (2) gained thick paste is mixed, drying is pulverized, and adds appropriate amount of auxiliary materials, sieves, and granulates, and incapsulates, and makes capsule, promptly.