CN111000969A - Pharmaceutical composition for treating simple obesity and preparation method thereof - Google Patents
Pharmaceutical composition for treating simple obesity and preparation method thereof Download PDFInfo
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Abstract
The invention provides a pharmaceutical composition for treating simple obesity and a preparation method thereof, and relates to the technical field of medicines. The prepared pharmaceutical composition has quick response and good curative effect, can reduce weight and relieve symptoms, achieves the aim of overall and systemic treatment, and can prevent and treat complications such as diabetes, lipid metabolism disorder, cardiovascular diseases and the like.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a pharmaceutical composition for treating simple obesity and a preparation method thereof.
Background
Obesity is a clinical syndrome, usually referred to as increased subcutaneous and visceral adipose tissue and weight gain in the body, while simple obesity refers to obesity of unknown etiology. The incidence of obesity is increasing year by year worldwide, is closely related to the occurrence of hypertension, diabetes, dyslipidemia, cardiovascular and cerebrovascular diseases and the like, seriously harms human health, and becomes one of public health problems worldwide. Recent researches show that the incidence rate of obesity in China is about 10-15%, the obesity is increased year by year and shows a trend of youthfulness, and the incidence rate of diseases related to the obesity also shows a trend of increasing.
The research on obesity in modern medicine mostly stays in the aspect of pathogenesis, and the treatment means for obesity is limited. The cause of obesity and the influence of obesity on the human body have long been recognized by traditional Chinese medicine. In the general review of the theory of deficiency and excess, Huangdi's classic of internal classic of the medicine, Wen Guiren's disease of Liliang is recorded, phlegm-dampness is considered as the main pathological change of obesity, and the deficiency, excess and excess of the principal pathological feature of obesity. At present, the obesity is rarely researched by the traditional Chinese medicine, and an excellent treatment method and an excellent medicine are not found so far. Although most medical doctors think that the main pathogenesis of obesity is spleen failure and transportation and dampness accumulation and phlegm generation, the diagnosis and treatment of obesity is not unified in the industry, the systemic and integral cognition is lack for the disease of the obesity syndrome, the disease differentiation and the syndrome differentiation are not well combined in the treatment process, the obesity is mechanically divided into the syndrome types of 'phlegm-dampness abundance in the interior', 'spleen deficiency and no circulation', 'skin-kidney yang deficiency', 'qi stagnation and blood stasis' and 'phlegm-blood stasis mutual connection', and the mutual connection and causal and symbiotic relationship among the syndrome types are artificially split, so the treatment is carried out, and the good and durable treatment effect is difficult to achieve clinically.
The ideal obesity drug has the basic requirements of safety, effectiveness, economy, high dependence and little side effect, so far, few weight-losing drugs with satisfactory curative effect exist, and the traditional Chinese medicine has the characteristics of safety, economy, little side effect, multiple targets and the like, and has wide research and development prospects. Chinese patent CN110193071A discloses a bitter cucurbita pepo traditional Chinese medicine composition, a preparation method and an application thereof, comprising: mixing ramulus Cinnamomi, radix Paeoniae alba, bupleuri radix, cortex Magnolia officinalis, fructus Aurantii Immaturus, caulis Bambusae in Taenia, radix Ophiopogonis, herba Agastaches, radix aucklandiae, fructus Amomi, rhizoma Pinelliae, herba Artemisiae Scopariae, semen Persicae, Scutellariae radix, rhizoma Coptidis, rhizoma corydalis and Glycyrrhrizae radix to form a Chinese medicinal mixture; mixing the Chinese medicinal mixture with alcoholic solution, soaking for 1-2 weeks, and filtering to obtain filtrate; adding rhizoma Zingiberis recens and Bulbus Allii into the filtrate, heating and concentrating to obtain Chinese medicinal mixed solution; adding bitter Cucurbita pepo powder into the Chinese medicinal mixture, heating, and stirring. Compared with the prior art, the traditional Chinese medicine composition has special effect for treating constipation and obesity, has no obvious toxic or side effect, no dependence and low cost, is easy to be accepted by patients with intractable and habitual constipation and obesity, and has good market prospect. However, the pharmaceutical composition of the invention is mainly used for treating obesity from the aspect of intestines and stomach, has certain defects in treatment of qi and blood, and cannot achieve the purpose of overall treatment.
Chinese patent CN103800876A discloses a traditional Chinese medicine for treating obesity, which comprises the following raw materials: the medicine is prepared by decocting radix astragali Preparata, radix Codonopsis, rhizoma Atractylodis, Saviae Miltiorrhizae radix, fructus crataegi, radix et rhizoma Rhei, folium Nelumbinis, Sargassum, thallus laminariae, Zingiberis rhizoma, Atractylodis rhizoma, bupleuri radix, pericarpium Citri Tangerinae, rhizoma Acori Graminei, Poria, Alismatis rhizoma, semen Cassiae, pericarpium Arecae and fructus Aurantii Immaturus with 700 ml of water to 200ml in the first preparation, and 500 ml of water to 200ml in the second preparation, twice a day, and taken in the morning and evening. The medicine has the advantages of quick effect, good curative effect, and good compatibility of medicines, thereby achieving the purpose of treating obesity. However, the main effect of the medicine is health care, and the medicine has slow effect for simple obesity patients and is difficult to achieve the purpose of treating the root cause.
Aiming at the problems that the traditional Chinese medicine has slow effect, poor curative effect, difficult overall treatment, easy occurrence of complications and the like when being used for treating obesity, a medicine composition with quick effect and good curative effect is sought, can reduce weight, relieve symptoms, achieve the overall and systemic treatment purpose, and simultaneously can prevent and treat complications such as diabetes, lipid metabolism disorder, cardiovascular disease and the like.
Disclosure of Invention
The pharmaceutical composition prepared by the preparation method can reduce the weight and relieve symptoms, achieves the overall and systemic treatment purpose, and can prevent and treat complications such as diabetes, lipid metabolism disorder, cardiovascular disease and the like.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the invention provides a pharmaceutical composition for treating simple obesity, which is prepared from raw materials including radix bupleuri, radix paeoniae alba, cassia twig, allium macrostemon, rhizoma atractylodis macrocephalae, fructus aurantii immaturus, cortex magnoliae officinalis, pericarpium citri reticulatae, poria cocos, grifola, rhizoma alismatis, rhizoma coptidis, red yeast rice, hawthorn, endothelium corneum gigeriae galli, radix astragali preparata, fried semen brassicae, fructus perillae, fried semen raphani, fructus trichosanthis, radix glycyrrhizae preparata, ginger, fructus ziziphi ju.
Further, the raw materials of the pharmaceutical composition comprise, by weight: 6-15 parts of radix bupleuri, 6-12 parts of radix paeoniae alba, 6-12 parts of cassia twig, 6-15 parts of allium macrostemon, 6-12 parts of rhizoma atractylodis macrocephalae, 6-12 parts of immature bitter orange, 6-12 parts of cortex magnoliae officinalis, 6-12 parts of pericarpium citri reticulatae, 9-15 parts of poria cocos, 9-15 parts of grifola, 10-15 parts of rhizoma alismatis, 6-12 parts of rhizoma coptidis, 6-15 parts of red yeast rice, 9-15 parts of hawthorn, 6-15 parts of endothelium corneum gigeriae galli, 10-20 parts of radix astragali preparata, 6-12 parts of fried semen brassicae alba, 6-12 parts of fructus perillae, 6-12 parts of fried semen raphani, 9-15 parts of fructus trichosanthis, 6-12 parts of radix glycyrrhizae preparata, 6-12 parts of.
Preferably, the raw materials of the pharmaceutical composition comprise, by weight: 8-12 parts of radix bupleuri, 8-10 parts of radix paeoniae alba, 8-10 parts of cassia twig, 8-12 parts of allium macrostemon, 8-10 parts of rhizoma atractylodis macrocephalae, 8-10 parts of immature bitter orange, 8-10 parts of cortex magnoliae officinalis, 8-10 parts of pericarpium citri reticulatae, 10-12 parts of poria cocos, 10-12 parts of grifola, 11-14 parts of rhizoma alismatis, 8-10 parts of rhizoma coptidis, 8-12 parts of red yeast rice, 10-15 parts of hawthorn, 8-12 parts of endothelium corneum gigeriae galli, 12-18 parts of radix astragali preparata, 8-10 parts of fried semen brassicae alba, 8-10 parts of fructus perillae, 8-10 parts of fried semen raphani, 10-12 parts of fructus trichosanthis, 8-10 parts of radix glycyrrhizae preparata, 8-10 parts of.
Still further preferably, the raw materials of the pharmaceutical composition comprise, in parts by weight: 12 parts of radix bupleuri, 10 parts of radix paeoniae alba, 10 parts of cassia twig, 10 parts of allium macrostemon, 10 parts of rhizoma atractylodis macrocephalae, 10 parts of immature bitter orange, 10 parts of mangnolia officinalis, 10 parts of pericarpium citri reticulatae, 10 parts of poria cocos, 10 parts of grifola, 12 parts of rhizoma alismatis, 10 parts of rhizoma coptidis, 10 parts of red yeast rice, 15 parts of hawthorn, 10 parts of endothelium corneum gigeriae galli, 15 parts of radix astragali preparata, 6 parts of fried semen brassicae, 10 parts of fructus perillae, 10 parts of fried semen raphani, 10 parts of fructus trichosanthis, 10 parts of radix glycyrrhiza.
Furthermore, the weight ratio of the cassia twig, the white paeony root, the ginger, the Chinese date and the honey-fried licorice root is 2-4:2-4:2-4:3-5: 2-4.
Preferably, the weight ratio of the cassia twig, the white paeony root, the ginger, the Chinese date and the honey-fried licorice root is 1:1:1: 1.
Furthermore, the weight ratio of the snakegourd fruit, the allium macrostemon, the immature bitter orange, the mangnolia officinalis and the cassia twig is 3-5:2-5:2-4:2-4: 2-4.
Preferably, the weight ratio of the snakegourd fruit to the allium macrostemon to the immature bitter orange to the magnolia officinalis to the cassia twig is 1:1:1: 1.
Furthermore, the weight ratio of the rhizoma atractylodis, the mangnolia officinalis, the dried orange peel, the honey-fried licorice root and the perilla seed is 1-2:1-2:1-2: 1-2.
Preferably, the weight ratio of the rhizoma atractylodis, the mangnolia officinalis, the dried orange peel, the honey-fried licorice root and the perilla seed is 1:1:1: 1.
Furthermore, the weight ratio of the bighead atractylodes rhizome to the poria cocos to the grifola to the rhizoma alismatis to the cassia twig is 6-12:9-15:9-15:10-15: 6-12.
Preferably, the weight ratio of the bighead atractylodes rhizome to the poria cocos to the polyporus umbellatus to the rhizoma alismatis to the cassia twig is 5:5:6: 5.
The invention also provides a preparation method of the pharmaceutical composition, which comprises the following steps: cleaning the raw materials, mixing, soaking in water, pouring out the soaking solution, decocting in water, filtering to obtain filtrate A, decocting in water, filtering to obtain filtrate B, and mixing the filtrates to obtain decoction.
Further, soaking in water at 25 deg.C for 50-55min based on the principle that the water is 2 cm higher than the medicinal plane when the medicinal materials are lightly pressed.
Further, the water is added for decoction, the water is 3-5 cm higher than the medicine plane when the medicinal materials are slightly pressed by the water added for two times, the water is added for decoction for the first time by strong fire for 20-30min after the water is decocted to be boiling, and the water is added for decoction for the second time by strong fire for 10-20min after the water is decocted to be boiling.
Further, the filtration was performed using 200 mesh filter cloth.
The technical effects obtained by the invention are as follows:
1. according to the invention, the cassia twig, the white paeony root, the ginger, the Chinese date and the honey-fried licorice root can coordinate ying and weiqi and promote blood circulation, and simultaneously, the deficiency of heart yang in upper jiao and deficiency-cold of spleen and stomach in middle jiao are considered; the radix bupleuri can dredge shaoyang, and the poria cocos and the grifola can dredge the triple warmer; the snakegourd fruit, the longstamen onion bulb, the immature bitter orange, the officinal magnolia bark and the cassia twig can activate yang and dissipate stagnation, reduce phlegm and promote qi circulation, regulate qi and relieve chest stuffiness, and simultaneously give consideration to the distending feeling of the stomach and the epigastrium in the middle-jiao, the constipation in the lower-jiao, the diarrhea and the blood stasis and phlegm stagnation in the blood system; the red yeast, the hawthorn and the chicken's gizzard-membrane can promote digestion and eliminate stagnation, and the coptis root can remove heat stagnated in the stomach and the intestine to jointly solve the problem of stomach strength; the rhizoma atractylodis, the mangnolia officinalis, the dried orange peel, the honey-fried licorice root and the perilla seed can resolve dampness, activate spleen, regulate qi and harmonize stomach, promote gastrointestinal peristalsis and improve digestion and absorption capacity; atractylodis rhizoma, Poria, Polyporus, Alismatis rhizoma and ramulus Cinnamomi for treating lower energizer by activating yang and inducing diuresis; radix astragali Preparata, Atractylodis rhizoma, radix Glycyrrhizae Preparata and Poria have effects of invigorating qi, invigorating spleen and treating qi system; the red sage root and the root bark of the peony tree are used for promoting blood circulation, removing blood stasis and treating blood system; white mustard seed is specially used for eliminating phlegm-dampness outside skin and striae; through reasonable medicine compatibility, multiple targets act on a human body, and the aim of overall and systemic treatment is achieved together.
2. The invention combines disease differentiation and dialectical differentiation to treat obesity which is a clinical syndrome, accurately grasps the development rule and characteristics of obesity phlegm dampness, integrally treats and relieves shaoyang, reasonably mixes the medicines, and finally prepares the medicine composition which can lighten the weight, relieve the symptoms and prevent and treat complications.
Detailed Description
It should be noted that the raw materials in the present application are all common commercial products, and therefore, the sources thereof are not particularly limited.
Example 1
The raw materials of the pharmaceutical composition for treating simple obesity comprise, by weight: 6 parts of radix bupleuri, 6 parts of radix paeoniae alba, 6 parts of cassia twig, 6 parts of allium macrostemon, 6 parts of rhizoma atractylodis macrocephalae, 6 parts of immature bitter orange, 6 parts of mangnolia officinalis, 6 parts of pericarpium citri reticulatae, 9 parts of poria cocos, 9 parts of grifola, 10 parts of rhizoma alismatis, 6 parts of rhizoma coptidis, 6 parts of red yeast rice, 9 parts of hawthorn, 6 parts of endothelium corneum gigeriae galli, 10 parts of radix astragali preparata, 6 parts of fried semen brassicae, 6 parts of fructus perillae, 6 parts of fried semen raphani, 9 parts of fructus trichosanthis, 6 parts of radix glycyrrhiza.
The preparation method of the pharmaceutical composition comprises the following steps: cleaning the raw materials, mixing, soaking in water at 25 deg.C for 50min, pouring out the soaking solution, decocting in water, filtering to obtain filtrate A, decocting in water, filtering to obtain filtrate B, and mixing the filtrates to obtain decoction.
Wherein, the water adding amount of the water soaking meets the condition that the water is 2 cm higher than the medicine plane when the medicinal materials are lightly pressed, and the principle of soaking the medicinal materials is taken; the water adding amount of the two times of decoction is 3 cm above the medicine plane when the medicinal materials are lightly pressed, the first time of decoction is carried out by using strong fire for decocting till boiling, and then the second time of decoction is carried out by using slow fire for decocting for 10 min; filtration was performed using 200 mesh filter cloth.
Example 2
The raw materials of the pharmaceutical composition for treating simple obesity comprise, by weight: 15 parts of radix bupleuri, 12 parts of radix paeoniae alba, 12 parts of cassia twig, 15 parts of allium macrostemon, 12 parts of rhizoma atractylodis macrocephalae, 12 parts of immature bitter orange, 12 parts of mangnolia officinalis, 12 parts of pericarpium citri reticulatae, 15 parts of poria cocos, 15 parts of grifola, 15 parts of rhizoma alismatis, 12 parts of rhizoma coptidis, 15 parts of red yeast rice, 15 parts of hawthorn, 15 parts of endothelium corneum gigeriae galli, 20 parts of radix astragali preparata, 12 parts of fried semen brassicae, 12 parts of fructus perillae, 12 parts of fried semen raphani, 15 parts of fructus trichosanthis, 12 parts of radix glycyrrhizae.
The preparation method of the pharmaceutical composition comprises the following steps: cleaning the raw materials, mixing, soaking in water at 25 deg.C for 55min, pouring out the soaking solution, decocting in water, filtering to obtain filtrate A, decocting in water, filtering to obtain filtrate B, and mixing the filtrates to obtain decoction.
Wherein, the water adding amount of the water soaking meets the condition that the water is 2 cm higher than the medicine plane when the medicinal materials are lightly pressed, and the principle of soaking the medicinal materials is taken; the water adding amount of the two times of decoction is 5 cm above the medicine plane when the medicinal materials are lightly pressed, the first time of decoction is carried out by strong fire until the materials are boiled, and then the first time of decoction is carried out by slow fire for 30min, and the second time of decoction is carried out by strong fire until the materials are boiled, and then the second time of decoction is carried out by slow fire for 20 min; filtration was performed using 200 mesh filter cloth.
Example 3
The raw materials of the pharmaceutical composition for treating simple obesity comprise, by weight: 12 parts of radix bupleuri, 10 parts of radix paeoniae alba, 10 parts of cassia twig, 10 parts of allium macrostemon, 10 parts of rhizoma atractylodis macrocephalae, 10 parts of immature bitter orange, 10 parts of mangnolia officinalis, 10 parts of pericarpium citri reticulatae, 10 parts of poria cocos, 10 parts of grifola, 12 parts of rhizoma alismatis, 10 parts of rhizoma coptidis, 10 parts of red yeast rice, 15 parts of hawthorn, 10 parts of endothelium corneum gigeriae galli, 15 parts of radix astragali preparata, 6 parts of fried semen brassicae, 10 parts of fructus perillae, 10 parts of fried semen raphani, 10 parts of fructus trichosanthis, 10 parts of radix glycyrrhiza.
The preparation method of the pharmaceutical composition comprises the following steps: cleaning the raw materials, mixing, soaking in water at 25 deg.C for 52min, pouring out the soaking solution, decocting in water, filtering to obtain filtrate A, decocting in water, filtering to obtain filtrate B, and mixing the filtrates to obtain decoction.
Wherein, the water adding amount of the water soaking meets the condition that the water is 2 cm higher than the medicine plane when the medicinal materials are lightly pressed, and the principle of soaking the medicinal materials is taken; the water adding amount of the two times of decoction is 4 cm above the medicine plane when the medicinal materials are lightly pressed, the first time of decoction is carried out by strong fire until the materials are boiled, and then the first time of decoction is carried out by slow fire for 25min, and the second time of decoction is carried out by strong fire until the materials are boiled, and then the second time of decoction is carried out by slow fire for 15 min; filtration was performed using 200 mesh filter cloth.
Example 4
The raw materials of the pharmaceutical composition for treating simple obesity comprise, by weight: 8 parts of radix bupleuri, 8 parts of radix paeoniae alba, 8 parts of cassia twig, 8 parts of allium macrostemon, 8 parts of rhizoma atractylodis macrocephalae, 8 parts of immature bitter orange, 8 parts of mangnolia officinalis, 8 parts of pericarpium citri reticulatae, 10 parts of poria cocos, 10 parts of grifola, 11 parts of rhizoma alismatis, 8 parts of rhizoma coptidis, 8 parts of red yeast rice, 10 parts of hawthorn, 8 parts of endothelium corneum gigeriae galli, 12 parts of radix astragali preparata, 8 parts of fried semen brassicae, 8 parts of fructus perillae, 8 parts of fried semen raphani, 10 parts of fructus trichosanthis, 8 parts of radix glycyrrhiza.
The preparation method of the pharmaceutical composition comprises the following steps: cleaning the raw materials, mixing, soaking in water at 25 deg.C for 50min, pouring out the soaking solution, decocting in water, filtering to obtain filtrate A, decocting in water, filtering to obtain filtrate B, and mixing the filtrates to obtain decoction.
Wherein, the water adding amount of the water soaking meets the condition that the water is 2 cm higher than the medicine plane when the medicinal materials are lightly pressed, and the principle of soaking the medicinal materials is taken; the water adding amount of the two times of decoction is 3 cm above the medicine plane when the medicinal materials are lightly pressed, the first time of decoction is carried out by using strong fire for decocting till boiling, and then the second time of decoction is carried out by using slow fire for decocting for 10 min; filtration was performed using 200 mesh filter cloth.
Example 5
The raw materials of the pharmaceutical composition for treating simple obesity comprise, by weight: 12 parts of radix bupleuri, 10 parts of radix paeoniae alba, 10 parts of cassia twig, 12 parts of allium macrostemon, 10 parts of rhizoma atractylodis macrocephalae, 10 parts of immature bitter orange, 10 parts of mangnolia officinalis, 10 parts of pericarpium citri reticulatae, 12 parts of poria cocos, 12 parts of grifola, 14 parts of rhizoma alismatis, 10 parts of rhizoma coptidis, 12 parts of red yeast rice, 15 parts of hawthorn, 12 parts of endothelium corneum gigeriae galli, 18 parts of radix astragali preparata, 10 parts of fried semen brassicae, 10 parts of fructus perillae, 10 parts of fried semen raphani, 12 parts of fructus trichosanthis, 10 parts of radix glycyrrhiza.
The preparation method of the pharmaceutical composition comprises the following steps: cleaning the raw materials, mixing, soaking in water at 25 deg.C for 55min, pouring out the soaking solution, decocting in water, filtering to obtain filtrate A, decocting in water, filtering to obtain filtrate B, and mixing the filtrates to obtain decoction.
Wherein, the water adding amount of the water soaking meets the condition that the water is 2 cm higher than the medicine plane when the medicinal materials are lightly pressed, and the principle of soaking the medicinal materials is taken; the water adding amount of the two times of decoction is 5 cm above the medicine plane when the medicinal materials are lightly pressed, the first time of decoction is carried out by strong fire until the materials are boiled, and then the first time of decoction is carried out by slow fire for 30min, and the second time of decoction is carried out by strong fire until the materials are boiled, and then the second time of decoction is carried out by slow fire for 20 min; filtration was performed using 200 mesh filter cloth.
Comparative example 1
The difference from the example 3 is only that the raw materials of the pharmaceutical composition comprise, in parts by weight: 4 parts of radix bupleuri, 14 parts of radix paeoniae alba, 4 parts of cassia twig, 16 parts of allium macrostemon, 4 parts of rhizoma atractylodis, 14 parts of rhizoma atractylodis macrocephalae, 4 parts of immature bitter orange, 14 parts of mangnolia officinalis, 4 parts of pericarpium citri reticulatae, 16 parts of poria cocos, 5 parts of grifola, 18 parts of rhizoma alismatis, 4 parts of rhizoma coptidis, 16 parts of red yeast rice, 5 parts of hawthorn, 18 parts of endothelium corneum gigeriae galli, 8 parts of radix astragali preparata, 14 parts of fried semen brassicae, 4 parts of fructus perillae, 14 parts of fried semen raphani, 5 parts of fructus trichosanthis, 14 parts of radix glycyrrhiza.
Comparative example 2
The difference from the example 3 is only that the weight ratio of the cassia twig, the white paeony root, the ginger, the Chinese date and the honey-fried licorice root is 1:5:1:6:1 (the total weight of the five medicinal materials is the same as that of the example 3).
Comparative example 3
The difference from the example 3 is only that the weight ratio of the snakegourd fruit, the allium macrostemon, the immature bitter orange, the officinal magnolia bark and the cassia twig is 2:6:1:5:1 (the total weight of the five medicinal materials is the same as that of the example 3).
Comparative example 4
The difference from the example 3 is that the weight ratio of the rhizoma atractylodis, the magnolia officinalis, the dried orange peel, the honey-fried licorice root and the perilla seed is 0.8:3:0.8:3:0.8 (the total weight of the five medicinal materials is the same as that of the example 3).
Comparative example 5
The difference from the example 3 is only that the weight ratio of the largehead atractylodes rhizome, the Indian buead, the grifola, the oriental waterplantain rhizome and the cassia twig is 5:16:8:16:5 (the total weight of the five medicinal materials is the same as that of the example 3).
Comparative example 6
The difference from the embodiment 3 is only that the preparation method of the traditional Chinese medicine composition comprises the following steps: cleaning the raw materials, mixing, soaking in water at 25 deg.C for 60min, pouring out the soaking solution, decocting in water, filtering to obtain filtrate A, decocting in water, filtering to obtain filtrate B, and mixing the filtrates to obtain decoction.
Wherein, the water adding amount of the water soaking meets the condition that the water is 2 cm higher than the medicine plane when the medicinal materials are lightly pressed, and the principle of soaking the medicinal materials is taken; the water adding amount of the two times of decoction is 4 cm above the medicine plane when the medicinal materials are lightly pressed, the first time of decoction is carried out by using strong fire for decocting till boiling, and then the second time of decoction is carried out by using slow fire for decocting for 22 min; filtration was performed using 200 mesh filter cloth.
The application of the Chinese medicinal composition tests for losing weight, reducing blood fat and reducing blood sugar
Test animals: 120 pure obese SD rats were divided into 12 groups of 10 rats each;
the test method comprises the following steps: each group of rats provided basal feed and had free drinking water, wherein 11 groups of rats were respectively administered with stomach irrigation to the concentrated decoction of the Chinese medicinal composition of examples 1-5 and comparative examples 1-6 (200 mL of the prepared decoction of the Chinese medicinal composition was concentrated 2 times to obtain concentrated decoction), once in the morning and at night, 2mL each time, the remaining group of rats were not administered with the drug, fed normally, and administered with the same amount of distilled water as the positive control group, and the weight of the rats before and after the test was continuously measured after 5 weeks, and the rate of increase in weight and the Lee's index (Lee's index ^ body weight (1/3) × 1000/body length) were calculated, and at the same time, the blood lipids (including Triglyceride (TG), cholesterol (TC) and low-density lipoprotein (LDL)) and blood glucose were measured for each group of rats, and the results were statistically reported in tables 1 and 2, respectively.
Test 1:
TABLE 1
Note: the data in the table are mean values; compared to the control group,: p < 0.05, x: p is less than 0.01.
As can be seen from Table 1, the weight gain rates of examples 1 to 5 and comparative examples 1 to 6 were all reduced compared to the control group, wherein the rate of increase of example 3 was relatively the lowest and the rate of increase of comparative examples 1 to 6 was higher than that of example 3. The Lee's index also follows this rule. Therefore, the pharmaceutical composition can effectively reduce the body weight and the Lee's index of rats, and the change of the drug content and the preparation method can influence the weight-reducing effect of the pharmaceutical composition.
Test 2:
TABLE 2
Examples of the invention | TG(mmol/L) | TC(mmol/L) | HDL(mmol/L) | Blood sugar (mug/L) |
Positive control group | 0.79 | 1.94 | 1.16 | 19.36 |
Example 1 | 0.51* | 1.23* | 1.03* | 5.91* |
Example 2 | 0.50* | 1.20* | 1.02* | 6.03* |
Example 3 | 0.42** | 1.04** | 0.92* | 4.32** |
Example 4 | 0.46* | 1.11* | 0.98* | 5.46* |
Example 5 | 0.48* | 1.12* | 1.00* | 5.59* |
Comparative example 1 | 0.65 | 1.53 | 1.12 | 12.32 |
Comparative example 2 | 0.56 | 1.32 | 1.10 | 10.03 |
Comparative example 3 | 0.53* | 1.28* | 1.08* | 9.31* |
Comparative example 4 | 0.47* | 1.12* | 0.98* | 5.61* |
Comparative example 5 | 0.50* | 1.18* | 1.02* | 6.03* |
Comparative example 6 | 0.45* | 1.09* | 0.94* | 4.87* |
Note: the data in the table are mean values; compared to the control group,: p < 0.05, x: p is less than 0.01.
As shown in Table 2, the blood lipid and blood glucose levels of the rats in examples 1-5 and comparative examples 1-6 are all reduced, wherein the blood lipid and blood glucose reducing ability of the pharmaceutical composition in example 3 is strongest, thereby showing that the pharmaceutical composition can effectively reduce the contents of triglyceride, cholesterol and low density lipoprotein in the blood lipid of the rats, and also can reduce the blood glucose level in the rats, and the changes of the pharmaceutical content and the preparation method influence the blood lipid and blood glucose reducing effects of the pharmaceutical composition.
Finally, it should be noted that the above-mentioned contents are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, and that the simple modifications or equivalent substitutions of the technical solutions of the present invention by those of ordinary skill in the art can be made without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A pharmaceutical composition for treating simple obesity, which is characterized in that: the raw materials comprise radix bupleuri, radix paeoniae alba, cassia twig, allium macrostemon, rhizoma atractylodis macrocephalae, fructus aurantii immaturus, mangnolia officinalis, pericarpium citri reticulatae, poria cocos, grifola, rhizoma alismatis, rhizoma coptidis, red yeast rice, hawthorn, endothelium corneum gigeriae galli, radix astragali preparata, fried semen brassicae, fructus perillae, fried semen raphani, fructus trichosanthis, radix glycyrrhizae preparata, ginger, Chinese date, radix.
2. The pharmaceutical composition of claim 1, wherein: the raw materials comprise the following components in parts by weight: 6-15 parts of radix bupleuri, 6-12 parts of radix paeoniae alba, 6-12 parts of cassia twig, 6-15 parts of allium macrostemon, 6-12 parts of rhizoma atractylodis macrocephalae, 6-12 parts of immature bitter orange, 6-12 parts of cortex magnoliae officinalis, 6-12 parts of pericarpium citri reticulatae, 9-15 parts of poria cocos, 9-15 parts of grifola, 10-15 parts of rhizoma alismatis, 6-12 parts of rhizoma coptidis, 6-15 parts of red yeast rice, 9-15 parts of hawthorn, 6-15 parts of endothelium corneum gigeriae galli, 10-20 parts of radix astragali preparata, 6-12 parts of fried semen brassicae alba, 6-12 parts of fructus perillae, 6-12 parts of fried semen raphani, 9-15 parts of fructus trichosanthis, 6-12 parts of radix glycyrrhizae preparata, 6-12 parts of.
3. The pharmaceutical composition of claim 2, wherein: the raw materials comprise the following components in parts by weight: 8-12 parts of radix bupleuri, 8-10 parts of radix paeoniae alba, 8-10 parts of cassia twig, 8-12 parts of allium macrostemon, 8-10 parts of rhizoma atractylodis, 8-10 parts of bighead atractylodes rhizome, 8-10 parts of immature bitter orange, 8-10 parts of mangnolia officinalis, 8-10 parts of dried orange peel, 10-12 parts of poria cocos, 10-12 parts of grifola, 11-14 parts of rhizoma alismatis, 8-10 parts of rhizoma coptidis, 8-12 parts of red yeast rice,
10-15 parts of hawthorn, 8-12 parts of endothelium corneum gigeriae galli, 12-18 parts of radix astragali preparata, 8-10 parts of fried semen brassicae, 8-10 parts of perilla fruit, 8-10 parts of fried semen raphani, 10-12 parts of snakegourd fruit, 8-10 parts of honey-fried licorice root, 8-10 parts of ginger, 10-12 parts of Chinese date, 8-10 parts of salvia miltiorrhiza and 8-10 parts of cortex moutan.
4. The pharmaceutical composition of claim 1, wherein: the weight ratio of the cassia twig, the white paeony root, the ginger, the Chinese date and the honey-fried licorice root is 2-4:2-4:2-4:3-5: 2-4.
5. The pharmaceutical composition of claim 1, wherein: the weight ratio of the snakegourd fruit to the allium macrostemon to the immature bitter orange to the magnolia officinalis to the cassia twig is 3-5:2-5:2-4:2-4: 2-4.
6. The pharmaceutical composition of claim 1, wherein: the weight ratio of the rhizoma atractylodis, the mangnolia officinalis, the dried orange peel, the honey-fried licorice root and the perilla seed is 1-2:1-2:1-2: 1-2.
7. The pharmaceutical composition of claim 1, wherein: the weight ratio of the bighead atractylodes rhizome to the poria cocos to the grifola to the rhizoma alismatis to the cassia twig is 6-12:9-15:9-15:10-15: 6-12.
8. Use of a pharmaceutical composition according to any one of claims 1 to 7 for the manufacture of a medicament for the treatment of simple obesity.
9. Use according to claim 8, characterized in that: the dosage forms of the medicine comprise decoction, capsules, tablets and pills.
10. Use according to claim 9, characterized in that: the preparation method of the decoction comprises the following steps: cleaning the raw materials, mixing, soaking in water, pouring out the soaking solution, decocting in water, filtering to obtain filtrate A, decocting in water, filtering to obtain filtrate B, and mixing the filtrates to obtain decoction.
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