CN101264220A - Medicaments assembly for tonifying kidney and invigorating spleen, activating blood circulation and removing stasis and preparation thereof - Google Patents
Medicaments assembly for tonifying kidney and invigorating spleen, activating blood circulation and removing stasis and preparation thereof Download PDFInfo
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Abstract
The invention discloses a Chinese herbal medicine composition that reinforces the kidney and strengthens the spleen and the preparation method. The effective components of the invention are extracted from astragalus, angelica sinensis, Radix Polygoni Multiflori Root, lanceolata, dodder, medlar, Red Ginseng, donkey hide gelatin, root of herbaceous peony, Largehead Atractylodes Rhizome, cornus officinalis, anemarrhena, ligustrum lucidum, colla carapacis et plastri testudinis, barrenwort, poria cocos, milettia reticulate and prepared rhizome of rehmanniae. The special medical active components in the invention have the functions of reinforcing the kidney, strengthening the spleen and activating blood circulation to dissipate blood stasis; the medicine composition is clinically used for symptoms such as thrombocytopenia, various anemia, and aplastic anemia.
Description
Technical field:
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to Chinese medicine composition of a kind of kidney and spleen invigorating, blood circulation promoting and blood stasis dispelling and preparation method thereof.
Technical background
Aplastic anemia (AA, be called for short aplastic anemia), be to change, cause marrow hematopoiesis function failure, the disease of main performance occurs being reduced to complete blood cell (erythrocyte, granulocyte, platelet) by bone marrow stem cell, hematopoieticmicroenviron-ment damage and immunologic mechanism that multiple reason causes.
The pathological change of aplastic anemia is mainly the fatization of red bone marrow, and that is to say has the red bone marrow of hemopoietic function to be replaced by fat originally, and the big more then anemia of the quantity of replacement is serious more.According to onset emergency, state of an illness weight, bone marrow destructiveness with lapse to etc., be divided into acute and chronic amphitypy.Investigate through some areas in China, per 100,000 philtrums have 1.87～2.1 people morbidity, and the sickness rate of reporting with Japan is close.Each age group all can be fallen ill, but sees with person between twenty and fifty more, and the male is more than the women.The ratio of acute and chronic type case is 1: 4.6.
Motherland's medical science thinks that primary disease belongs to asthenia, and is deficient, categories such as blood disorder.The traditional Chinese medical science is thought kidney governing bones, and bone is given birth to marrow, and marrow is similar, essence and blood sharing the same origin, and the essence and blood mutual promotion transforms each other.Aplastic anemia is the hemopoietic obstacle that the bone marrow strain causes, and the kidney being the origin of congenital constitution, essence and blood dirty, deficiency of the kidney, then bone marrow does not fill, marrow void then essence and blood can not demutation, but simple the kidney invigorating often the suburb fruit is bad, this is because the spleen kidney has first day after tomorrow of dependence, spleen is a source of generating QI and blood, both so-called congenital taste day after tomorrow, support congenital the day after tomorrow, add with its curative effect of drugs strengthening spleen more obvious in the kidney invigorating.We find also that in clinical drug for invigorating blood circulation and eliminating stasis has the hematopoieticmicroenviron-ment of improvement and regulates immunization, can remove the resistance of the brain stasis of blood and the growth that helps cell both blood stasis do not go, fresh blood is not given birth to.Using kidney and spleen invigorating medicine poor effect and do not having the case of obvious bleeding tendency, adding with drug for invigorating blood circulation and eliminating stasis and often can obtain good curative effect.
The present invention closes clinical many years of experience prescription according to the traditional ancient reef knot, in the side all medicines share have kidney and spleen invigorating, the effect of blood circulation promoting and blood stasis dispelling, played the effect for the treatment of both the principal and secondary aspects of a disease for treatment aplastic anemia.
Summary of the invention:
One of purpose of the present invention provides the Chinese medicine composition of a kind of kidney and spleen invigorating, blood circulation promoting and blood stasis dispelling.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Radix Astragali 100-300 part Radix Angelicae Sinensis 100-300 part Radix Polygoni Multiflori 100-300 part
Radix Codonopsis 100-300 part Semen Cuscutae 100-300 part Fructus Lycii 100-300 part
Radix Ginseng Rubra 100-300 part Colla Corii Asini 100-300 part Radix Paeoniae Alba 100-300 part
Rhizoma Atractylodis Macrocephalae 100-300 part Fructus Corni 100-300 part Rhizoma Anemarrhenae 100-300 part
Fructus Ligustri Lucidi 100-300 part Colla Plastri Testudinis 100-300 part Herba Epimedii 100-300 part
Poria 100-300 part Caulis Spatholobi 100-300 part Radix Rehmanniae Preparata 100-300 part
The active component that preferred following raw materials according is made, curative effect is better:
150 parts of 200 parts of Radix Polygoni Multiflori of 200 parts of Radix Angelicae Sinensis of the Radix Astragali
100 parts of 100 parts of Fructus Lycii of 200 parts of Semen Cuscutae of Radix Codonopsis
150 parts of 150 portions of Radix Paeoniae Albas of 150 parts of Colla Corii Asini of Radix Ginseng Rubra
150 parts of 150 parts of Rhizoma Anemarrhenaes of 150 parts of Fructus Corni of the Rhizoma Atractylodis Macrocephalae
150 parts of 150 parts of Herba Epimedii of 150 parts of Colla Plastri Testudinises of Fructus Ligustri Lucidi
150 parts of Radix Rehmanniae Preparata 100-300 of 200 portions of Caulis Spatholobis of Poria part
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Astragali, Radix Angelicae Sinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) all the other Radix Polygoni Multiflori, Radix Codonopsis, Semen Cuscutae, Fructus Lycii, Radix Ginseng Rubra, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Rhizoma Anemarrhenae, Fructus Ligustri Lucidi, Herba Epimedii, Poria, Caulis Spatholobi, medical materials such as Radix Rehmanniae Preparata add 10 times of decoctings and boil three times, 1 hour for the first time, second, three times 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, Colla Plastri Testudinis stirs to make and dissolves, and concentrating under reduced pressure becomes the thick paste of 1.28～1.32 (80 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has the effect of kidney and spleen invigorating, blood circulation promoting and blood stasis dispelling, be used for clinically aplastic anemia and diseases such as other all kinds anemia, thrombocytopenia.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
1. write out a prescription:
150 parts of 200 parts of Radix Polygoni Multiflori of 200 parts of Radix Angelicae Sinensis of the Radix Astragali
100 parts of 100 parts of Fructus Lycii of 200 parts of Semen Cuscutae of Radix Codonopsis
150 parts of 150 portions of Radix Paeoniae Albas of 150 parts of Colla Corii Asini of Radix Ginseng Rubra
150 parts of 150 parts of Rhizoma Anemarrhenaes of 150 parts of Fructus Corni of the Rhizoma Atractylodis Macrocephalae
150 parts of 150 parts of Herba Epimedii of 150 parts of Colla Plastri Testudinises of Fructus Ligustri Lucidi
150 parts of Radix Rehmanniae Preparata 100-300 of 200 portions of Caulis Spatholobis of Poria part
2. preparation technology
(1) Radix Astragali, Radix Angelicae Sinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) all the other Radix Polygoni Multiflori, Radix Codonopsis, Semen Cuscutae, Fructus Lycii, Radix Ginseng Rubra, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Rhizoma Anemarrhenae, Fructus Ligustri Lucidi, Herba Epimedii, Poria, Caulis Spatholobi, medical materials such as Radix Rehmanniae Preparata add 10 times of decoctings and boil three times, 1 hour for the first time, second, three times 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, Colla Plastri Testudinis stirs to make and dissolves, and concentrating under reduced pressure becomes the thick paste of 1.28～1.32 (80 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription:
150 parts of 200 parts of Radix Polygoni Multiflori of 200 parts of Radix Angelicae Sinensis of the Radix Astragali
100 parts of 100 parts of Fructus Lycii of 200 parts of Semen Cuscutae of Radix Codonopsis
150 parts of 150 portions of Radix Paeoniae Albas of 150 parts of Colla Corii Asini of Radix Ginseng Rubra
150 parts of 150 parts of Rhizoma Anemarrhenaes of 150 parts of Fructus Corni of the Rhizoma Atractylodis Macrocephalae
150 parts of 150 parts of Herba Epimedii of 150 parts of Colla Plastri Testudinises of Fructus Ligustri Lucidi
150 parts of Radix Rehmanniae Preparata 100-300 of 200 portions of Caulis Spatholobis of Poria part
2. preparation technology:
(1) Radix Astragali, Radix Angelicae Sinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) all the other Radix Polygoni Multiflori, Radix Codonopsis, Semen Cuscutae, Fructus Lycii, Radix Ginseng Rubra, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Rhizoma Anemarrhenae, Fructus Ligustri Lucidi, Herba Epimedii, Poria, Caulis Spatholobi, medical materials such as Radix Rehmanniae Preparata add 10 times of decoctings and boil three times, 1 hour for the first time, second, three times 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, Colla Plastri Testudinis stirs to make and dissolves, and concentrating under reduced pressure becomes the thick paste of 1.28～1.32 (80 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
150 parts of 200 parts of Radix Polygoni Multiflori of 200 parts of Radix Angelicae Sinensis of the Radix Astragali
100 parts of 100 parts of Fructus Lycii of 200 parts of Semen Cuscutae of Radix Codonopsis
150 parts of 150 portions of Radix Paeoniae Albas of 150 parts of Colla Corii Asini of Radix Ginseng Rubra
150 parts of 150 parts of Rhizoma Anemarrhenaes of 150 parts of Fructus Corni of the Rhizoma Atractylodis Macrocephalae
150 parts of 150 parts of Herba Epimedii of 150 parts of Colla Plastri Testudinises of Fructus Ligustri Lucidi
150 parts of Radix Rehmanniae Preparata 100-300 of 200 portions of Caulis Spatholobis of Poria part
2. preparation technology:
(1) Radix Astragali, Radix Angelicae Sinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) all the other Radix Polygoni Multiflori, Radix Codonopsis, Semen Cuscutae, Fructus Lycii, Radix Ginseng Rubra, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Rhizoma Anemarrhenae, Fructus Ligustri Lucidi, Herba Epimedii, Poria, Caulis Spatholobi, medical materials such as Radix Rehmanniae Preparata add 10 times of decoctings and boil three times, 1 hour for the first time, second, three times 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, Colla Plastri Testudinis stirs to make and dissolves, and concentrating under reduced pressure becomes the thick paste of 1.28～1.32 (80 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, the Chinese medicine composition of a kind of kidney and spleen invigorating, blood circulation promoting and blood stasis dispelling is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Radix Astragali 100-300 part Radix Angelicae Sinensis 100-300 part Radix Polygoni Multiflori 100-300 part
Radix Codonopsis 100-300 part Semen Cuscutae 100-300 part Fructus Lycii 100-300 part
Radix Ginseng Rubra 100-300 part Colla Corii Asini 100-300 part Radix Paeoniae Alba 100-300 part
Rhizoma Atractylodis Macrocephalae 100-300 part Fructus Corni 100-300 part Rhizoma Anemarrhenae 100-300 part
Fructus Ligustri Lucidi 100-300 part Colla Plastri Testudinis 100-300 part Herba Epimedii 100-300 part
Poria 100-300 part Caulis Spatholobi 100-300 part Radix Rehmanniae Preparata 100-300 part
2, the Chinese medicine composition of a kind of kidney and spleen invigorating according to claim 1, blood circulation promoting and blood stasis dispelling is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
150 parts of 200 parts of Radix Polygoni Multiflori of 200 parts of Radix Angelicae Sinensis of the Radix Astragali
100 parts of 100 parts of Fructus Lycii of 200 parts of Semen Cuscutae of Radix Codonopsis
150 parts of 150 portions of Radix Paeoniae Albas of 150 parts of Colla Corii Asini of Radix Ginseng Rubra
150 parts of 150 parts of Rhizoma Anemarrhenaes of 150 parts of Fructus Corni of the Rhizoma Atractylodis Macrocephalae
150 parts of 150 parts of Herba Epimedii of 150 parts of Colla Plastri Testudinises of Fructus Ligustri Lucidi
150 parts of Radix Rehmanniae Preparata 100-300 of 200 portions of Caulis Spatholobis of Poria part
3, according to the Chinese medicine composition of the described a kind of kidney and spleen invigorating of claim 1-2, blood circulation promoting and blood stasis dispelling, it is characterized in that adopting following method to make:
(1) Radix Astragali, Radix Angelicae Sinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) all the other Radix Polygoni Multiflori, Radix Codonopsis, Semen Cuscutae, Fructus Lycii, Radix Ginseng Rubra, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, the Rhizoma Anemarrhenae, Fructus Ligustri Lucidi, Herba Epimedii, Poria, Caulis Spatholobi, medical materials such as Radix Rehmanniae Preparata add 10 times of decoctings and boil three times, 1 hour for the first time, second, three times 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, Colla Plastri Testudinis stirs to make and dissolves, and concentrating under reduced pressure becomes the thick paste of 1.28～1.32 (80 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4,, it is characterized in that this Chinese medicine composition is an oral formulations according to the Chinese medicine composition of any one described a kind of kidney and spleen invigorating, blood circulation promoting and blood stasis dispelling among the claim 1-3.
5,, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet according to the Chinese medicine composition of the described a kind of kidney and spleen invigorating of claim 3-4, blood circulation promoting and blood stasis dispelling.
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| CN101596255B (en) * | 2009-06-26 | 2011-06-15 | 曹志强 | Chinese medicament for preventing and curing leucemia |
| CN102512615A (en) * | 2011-12-15 | 2012-06-27 | 天长市中医院 | Traditional Chinese medicinal composition used for cancer recovery stage |
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| CN103356944A (en) * | 2013-06-26 | 2013-10-23 | 柳晖 | Chinese medicine composition for treating anemia |
| CN103385975A (en) * | 2013-07-01 | 2013-11-13 | 冯子政 | Traditional Chinese medicine for treating thrombocytopenia |
| CN103505679A (en) * | 2013-08-30 | 2014-01-15 | 杜丽娟 | Drug for treating blood diseases, preparation method, and applications thereof |
| CN104606343A (en) * | 2014-12-12 | 2015-05-13 | 上海市普陀区中心医院 | Spleen invigorating and kidney tonifying traditional Chinese medicine and decoction preparation method |
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| CN101596255B (en) * | 2009-06-26 | 2011-06-15 | 曹志强 | Chinese medicament for preventing and curing leucemia |
| CN102512615B (en) * | 2011-12-15 | 2014-08-06 | 天长市中医院 | Traditional Chinese medicinal composition used for cancer recovery stage |
| CN102512615A (en) * | 2011-12-15 | 2012-06-27 | 天长市中医院 | Traditional Chinese medicinal composition used for cancer recovery stage |
| CN103125935A (en) * | 2013-02-02 | 2013-06-05 | 安徽惠尔普生物科技发展有限责任公司 | Fleece-flower root amino acid oral liquid and preparation method thereof |
| CN103356944A (en) * | 2013-06-26 | 2013-10-23 | 柳晖 | Chinese medicine composition for treating anemia |
| CN103356944B (en) * | 2013-06-26 | 2015-08-05 | 尹爱良 | A kind of Chinese medicine composition for the treatment of anemia |
| CN103385975A (en) * | 2013-07-01 | 2013-11-13 | 冯子政 | Traditional Chinese medicine for treating thrombocytopenia |
| CN103505679A (en) * | 2013-08-30 | 2014-01-15 | 杜丽娟 | Drug for treating blood diseases, preparation method, and applications thereof |
| CN103505679B (en) * | 2013-08-30 | 2015-05-20 | 杜丽娟 | Drug for treating blood diseases, preparation method, and applications thereof |
| CN104606343A (en) * | 2014-12-12 | 2015-05-13 | 上海市普陀区中心医院 | Spleen invigorating and kidney tonifying traditional Chinese medicine and decoction preparation method |
| CN104921111A (en) * | 2015-05-28 | 2015-09-23 | 桐城市佳明农业发展有限公司 | Mushroom duck meat porridge and preparation thereof |
| CN108157563A (en) * | 2018-03-12 | 2018-06-15 | 童国柱 | A kind of kidney and spleen invigorating mountain cornel tea |
| CN114588214A (en) * | 2022-03-15 | 2022-06-07 | 东莞市中医院 | Composition and granules for improving bone marrow suppression after chemotherapy and preparation method |
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Open date: 20080917 |