CN101537099A - Chinese traditional medicine composition for curing chronic nephritis and preparation method thereof - Google Patents
Chinese traditional medicine composition for curing chronic nephritis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese traditional medicine composition for curing chronic nephritis and a preparation method thereof. The Chinese traditional medicine composition is prepared by the following bulk drugs according to proportioning by weight: 10 to 30 parts of astragalus root, 10 to 30 parts of prepared rehmannia root, 10 to 30 parts of tuber fleeceflower, 10 to 20 parts of pilose asiabell root, 10 to 20 parts of white atractylodes rhizome, 10 to 20 parts of ledebouriella root, 10 to 20 parts of achyranthes root, 10 to 20 parts of grifola umbellate, 10 to 20 parts of indian bread, 10 to 20 parts of Chinese yam, 10 to 20 parts of wolfberry fruit and 3 to 10 parts of liquorice. The invention has the effects of tonifying kidney and strengthening spleen, supplementing qi and nourishing yin and clearing damp and promoting diuresis, is used for curing various symptoms such as edema, lumbar aching pain, night sweating, spontaneous perspiratio and fatigue or dizziness and tinnitus, hot palms and soles, fine number of arteries and veins or heavy fine, and the like caused by the chronic nephritis, and also has better therapeutic effect for curing patients with urine protein of long-term indigestion.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of chronic nephritis and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
Chronic nephritis is the one group of immune disease that clinical manifestation is similar, pathological change differs, prognosis is not quite similar that is primary in glomerule that is caused by multiple reason, belong to categories such as motherland's medical science " edema ", " asthenia ", " lumbago ", clinical edema, albuminuria, hematuria, cylinderuria, hypertension and the renal function in various degree of mainly showing as goes down etc.
Because irrational diet and bad life habits constantly rise the prevalence of diseases such as obesity, diabetes, hypertension, hyperlipidemia, metabolic arthritis, and directly caused improving constantly of chronic kidney disease prevalence thus, simultaneously, the abuse of medicine and aged tendency of population have also improved the prevalence of chronic kidney disease.The Epidemiological study result shows that in the world wide, per ten philtrums just have a chronic kidney disease patient.Because the primary disease course of disease is long, the state of an illness is made slow progress mostly, engenders that renal function goes down, and the part conditions of patients can be subjected to some factor affecting and deterioration and develop into uremia rapidly in a short time.
Because the paathogenic factor complexity of chronic nephritis, although the modern medicine development speed is very fast, but up to now, the cause of disease of most of chronic nephritiss is still unclear, at present, to the treatment of chronic nephritis still based on symptomatic treatment, clinical glucocorticoid and the cytotoxic drug mainly selected for use treated, to there being the edema patient to use always with diuretic with mitigation symptoms, to there being hypertensive patient often to be equipped with depressor with stabilizing blood pressure, still there is not effective Therapeutic Method at present both at home and abroad, so that quite a lot of chronic nephritis patient finally develops into uremia and threat to life.
Summary of the invention
One of the object of the invention is to provide a kind of Chinese medicine composition for the treatment of chronic nephritis, said composition has the effect of kidney and spleen invigorating, supplementing QI and nourishing YIN, promoting diuresis to eliminate damp pathogen, be used for the treatment of chronic nephritis, disease is seen edema, ache of the spinal column, spontaneous perspiration anorexia, fatigue and weakness or dizziness and tinnitus, feverish sensation in the palms and soles, deep-thready pulse or count accurately etc. also has better therapeutic effect to the urine protein person that do not disappear for a long time.
Two of the object of the invention is to provide the preparation method of this Chinese medicine composition.
Chronic nephritis belongs to the card of deficiency in origin and excess in superficiality, and void shows that mainly lung, spleen, kidney three dirty differences are deficient, comparatively sees to suffer from a deficiency of the kidney more; The domination of pathogen comprises multiple risk factor, based on damp and hot, blood stasis.Clinical existing edema, the urine protein of having more of chronic nephritis patient, its edema mainly are dirty with lung, spleen, kidney three and three warmers are relevant to the imbalance of water liquid metabolic function, the exopathogen invasion and attack, impairment of purifying and descending function of the lung, cause facial edema or or increase the weight of spleen, kidney two empty caused edema; Insufficiency of the spleen can not fortune then water is wet stores; Suffering from a deficiency of the kidney can not activating QI, also can cause that water is wet to store; Three warmers are the road of water liquid operation, and qiactivity of triple energizer is not normal, and it is dirty directly to have influence on lung, spleen, kidney three; Albumen is the precise and tiny of human body, by spleen biochemistry, hides by kidney envelope, and insufficiency of the spleen then essence from food flowing downward, precise and tiny making a bet, the then instability of kidney QI of suffering from a deficiency of the kidney is precise and tinyly let out down, and albuminuria is due to the spleen kidney two deficiency of five ZANG-organs damage.
The present invention is on clinical treatment experience basis for many years, in conjunction with the modern study achievement, it is basic to cause a disease at chronic nephritis, consolidate with kidney and spleen invigorating, QI invigorating and to be the basic rule of treatment, selectedly have spleen reinforcing, reinforce the kidney, the product of QI invigorating, yin nourishing, use modern preparation technique, be processed into the pure Chinese medicinal preparation of the treatment chronic nephritis that is suitable for wide clinical application.QI invigorating of the present invention consolidates, activating QI to promote diuresis, can recover the metabolism of normal water liquid, and after the clinical application, clinical symptoms such as patient's edema, pharyngalgia, lumbago, dizzy weak, frequent urination at night all have clear improvement, and part patient urine protein reduces gradually.
The Chinese medicine composition of treatment chronic nephritis provided by the invention is characterized in that said composition is to be made by following raw materials by weight proportions:
The Radix Astragali 10～30 weight portion Radix Rehmanniae Preparata 10～30 weight portion Radix Polygoni Multiflori 10～30 weight portions
Radix Codonopsis 10～20 weight portion Rhizoma Atractylodis Macrocephalaes 10～20 weight portion Radix Saposhnikoviaes 10～20 weight portions
Radix Achyranthis Bidentatae 10～20 weight portion Polyporus 10～20 weight portion Poria 10～20 weight portions
Rhizoma Dioscoreae 10～20 weight portion Fructus Lycii 10～20 weight portion Radix Glycyrrhizaes 3～10 weight portions
Further, on the basis that the above-mentioned raw materials medicine is formed, the weight proportion of the crude drug of Chinese medicine composition of the present invention can be adopted as especially:
The Radix Astragali 30 weight portion Radix Rehmanniae Preparata 20 weight portion Radix Polygoni Multiflori 20 weight portions
The Radix Codonopsis 20 weight portion Rhizoma Atractylodis Macrocephalaes 20 weight portion Radix Saposhnikoviaes 20 weight portions
Radix Achyranthis Bidentatae 20 weight portion Polyporus 10 weight portion Poria 10 weight portions
Rhizoma Dioscoreae 10 weight portion Fructus Lycii 10 weight portion Radix Glycyrrhizaes 6 weight portions
The present invention realizes by following preparation method:
(1) get the Radix Astragali, Radix Codonopsis powder is broken into coarse powder, adds 6～10 times of amount 50～95% ethanol, reflux, extract, 2～4 times, each 2～4 hours, extract pure liquid and filter, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.05～1.30 (50～70 ℃), and is standby; Medicinal residues are standby;
(2) get Radix Rehmanniae Preparata, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, Radix Achyranthis Bidentatae, Polyporus, Poria, Rhizoma Dioscoreae, Fructus Lycii, Radix Glycyrrhizae powder and be broken into coarse powder, add step (1) gained medicinal residues, decoct 2～3 times with 8～12 times of water gagings, each 1～3 hour, decocting liquid filters, it is 1.05～1.30 clear paste that filtrate is concentrated into relative density, standby;
(3) get step (1) and step (2) gained clear paste, merge, drying is ground into fine powder;
(4) get step (3) gained dried cream powder, formulation method adds the conventional formulation adjuvant routinely, molding, and packing, check gets product.
The present invention can be processed into acceptable tablet, capsule, the arbitrary dosage form of pill clinically.
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.
Embodiment 1
(1) get Radix Astragali 300g, Radix Codonopsis 200g, be ground into coarse powder, add 10 times of amount 75% ethanol, reflux, extract, 2 hours is extracted pure liquid and is filtered; Medicinal residues add 8 times of amount 75% ethanol, and reflux, extract, 2 hours is extracted pure liquid and filtered; Medicinal residues add 8 times of amount 75% ethanol again, and reflux, extract, 2 hours is extracted pure liquid and filtered, merging filtrate, and decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.20 (55 ℃), and is standby; Medicinal residues are standby;
(2) get Radix Rehmanniae Preparata 200g, Radix Polygoni Multiflori 200g, Rhizoma Atractylodis Macrocephalae 200g, Radix Saposhnikoviae 200g, Radix Achyranthis Bidentatae 200g, Polyporus 100g, Poria 100g, Rhizoma Dioscoreae 100g, Fructus Lycii 100g, Radix Glycyrrhizae 60g, be ground into coarse powder, add step (1) gained medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1 hour, and decocting liquid filters; Medicinal residues add 8 times of water gagings again and decocted 1 hour, and decocting liquid filters, and merging filtrate is concentrated into relative density and is 1.20 clear paste under 70 ℃ of conditions, standby;
(3) get step (1) and step (2) gained clear paste, merge, mix homogeneously, drying is ground into fine powder, and the powder that gets dry extract is standby;
(4) get step (3) gained dried cream powder, add 0.6% magnesium stearate, mix homogeneously, encapsulated, packing, check promptly gets capsule.
Embodiment 2
(1) get Radix Astragali 300g, Radix Codonopsis 200g, be ground into coarse powder, add 8 times of amount 75% ethanol, reflux, extract, 4 hours is extracted pure liquid and is filtered; Medicinal residues add 8 times of amount 75% ethanol, and reflux, extract, 3 hours is extracted pure liquid and filtered; Medicinal residues add 8 times of amount 75% ethanol again, and reflux, extract, 2 hours is extracted pure liquid and filtered, merging filtrate, and decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.10 (55 ℃), and is standby; Medicinal residues are standby;
(2) get Radix Rehmanniae Preparata 200g, Radix Polygoni Multiflori 200g, Rhizoma Atractylodis Macrocephalae 200g, Radix Saposhnikoviae 200g, Radix Achyranthis Bidentatae 200g, Polyporus 100g, Poria 100g, Rhizoma Dioscoreae 100g, Fructus Lycii 100g, Radix Glycyrrhizae 60g, be ground into coarse powder, add step (1) gained medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1 hour, and decocting liquid filters; Medicinal residues add 10 times of water gagings again and decocted 1 hour, and decocting liquid filters, and merging filtrate is concentrated into relative density and is 1.10 clear paste, and is standby;
(3) get step (1) and step (2) gained clear paste, merge, mix homogeneously, spray drying, the powder that gets dry extract, standby;
(4) get step (3) gained dried cream powder, use 75% alcohol granulation, drying, granulate;
(5) get step (4) gained granule, add 0.4% magnesium stearate, mix homogeneously, tabletting, packing, check promptly gets tablet.
Claims (3)
1, the Chinese medicine composition of treatment chronic nephritis is characterized in that said composition is to be made by following raw materials by weight proportions:
The Radix Astragali 10～30 weight portion Radix Rehmanniae Preparata 10～30 weight portion Radix Polygoni Multiflori 10～30 weight portions
Radix Codonopsis 10～20 weight portion Rhizoma Atractylodis Macrocephalaes 10～20 weight portion Radix Saposhnikoviaes 10～20 weight portions
Radix Achyranthis Bidentatae 10～20 weight portion Polyporus 10～20 weight portion Poria 10～20 weight portions
Rhizoma Dioscoreae 10～20 weight portion Fructus Lycii 10～20 weight portion Radix Glycyrrhizaes 3～10 weight portions
2, Chinese medicine composition as claimed in claim 1 is characterized in that said composition is to be made by following raw materials by weight proportions:
The Radix Astragali 30 weight portion Radix Rehmanniae Preparata 20 weight portion Radix Polygoni Multiflori 20 weight portions
The Radix Codonopsis 20 weight portion Rhizoma Atractylodis Macrocephalaes 20 weight portion Radix Saposhnikoviaes 20 weight portions
Radix Achyranthis Bidentatae 20 weight portion Polyporus 10 weight portion Poria 10 weight portions
Rhizoma Dioscoreae 10 weight portion Fructus Lycii 10 weight portion Radix Glycyrrhizaes 6 weight portions
3, the preparation method of Chinese medicine composition as claimed in claim 1 or 2 is characterized in that this method is:
(1) get the Radix Astragali, Radix Codonopsis powder is broken into coarse powder, adds 6～10 times of amount 50～95% ethanol, reflux, extract, 2～4 times, each 2～4 hours, extract pure liquid and filter, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.05～1.30 (50～70 ℃), and is standby; Medicinal residues are standby;
(2) get Radix Rehmanniae Preparata, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, Radix Achyranthis Bidentatae, Polyporus, Poria, Rhizoma Dioscoreae, Fructus Lycii, Radix Glycyrrhizae powder and be broken into coarse powder, add step (1) gained medicinal residues, decoct 2～3 times with 8～12 times of water gagings, each 1～3 hour, decocting liquid filters, it is 1.05～1.30 clear paste that filtrate is concentrated into relative density, standby;
(3) get step (1) and step (2) gained clear paste, merge, drying is ground into fine powder;
(4) get step (3) gained dried cream powder, formulation method adds the conventional formulation adjuvant routinely, molding, and packing, check gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810102449 CN101537099A (en) | 2008-03-21 | 2008-03-21 | Chinese traditional medicine composition for curing chronic nephritis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200810102449 CN101537099A (en) | 2008-03-21 | 2008-03-21 | Chinese traditional medicine composition for curing chronic nephritis and preparation method thereof |
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| CN101537099A true CN101537099A (en) | 2009-09-23 |
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| CN 200810102449 Pending CN101537099A (en) | 2008-03-21 | 2008-03-21 | Chinese traditional medicine composition for curing chronic nephritis and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991799A (en) * | 2010-11-24 | 2011-03-30 | 杨春元 | Medicine for treating nephritis |
| CN102600392A (en) * | 2012-04-09 | 2012-07-25 | 刘凌 | Traditional Chinese medicine enema for treating chronic renal failure |
| CN102614489A (en) * | 2012-04-24 | 2012-08-01 | 潍坊诺达药业有限公司 | Medicinal composition for treating renal edema of livestock and poultry and preparation method for medicinal composition |
| CN103007075A (en) * | 2012-11-21 | 2013-04-03 | 王意谦 | Chinese medicinal composition for treating chronic glomerulo nephritis |
-
2008
- 2008-03-21 CN CN 200810102449 patent/CN101537099A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991799A (en) * | 2010-11-24 | 2011-03-30 | 杨春元 | Medicine for treating nephritis |
| CN102600392A (en) * | 2012-04-09 | 2012-07-25 | 刘凌 | Traditional Chinese medicine enema for treating chronic renal failure |
| CN102600392B (en) * | 2012-04-09 | 2013-08-28 | 赵现波 | Traditional Chinese medicine enema for treating chronic renal failure |
| CN102614489A (en) * | 2012-04-24 | 2012-08-01 | 潍坊诺达药业有限公司 | Medicinal composition for treating renal edema of livestock and poultry and preparation method for medicinal composition |
| CN103007075A (en) * | 2012-11-21 | 2013-04-03 | 王意谦 | Chinese medicinal composition for treating chronic glomerulo nephritis |
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Open date: 20090923 |