CN101961469B - Traditional Chinese medicine for treating infantile anorexia due to insufficiency of spleen-qi and stomach-qi and preparation method thereof - Google Patents
Traditional Chinese medicine for treating infantile anorexia due to insufficiency of spleen-qi and stomach-qi and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating infantile anorexia due to insufficiency of spleen-qi and stomach-qi and a preparation method thereof. The medicament is characterized by being an oral preparation processed from the following Chinese medicinal materials in part by weight: 3 to 15 parts of codonopsis pilosula, 1 to 5 parts of deep-fried largehead atractylodes rhizome, 3 to 15 parts of Indian buead, 3 to 15 parts of dioscorea opposita thumb, 3 to 15 parts of coix seed, 3 to 9 parts of charred hawthorn fruit, 3 to 15 parts of malt, 1 to 5 parts of officinal magnolia bark and 1 to 5 parts of roasted liquoric root. The medicament can be prepared into any common oral formulation such as tablets, capsules, particles, oral liquid, syrup and the like. The Traditional Chinese medicine has the effects of invigorating the spleen, excreting dampness, regulating the middle warmer and waking stomach and is suitable for treating the infantile anorexia due to the insufficiency of the spleen-qi and stomach-qi.
Description
One, technical field
The present invention relates to a kind of herbal mixture and processing method thereof, exactly is a kind of Chinese medicine for the treatment of the spleen and stomach in children qi-deficiency type apositia and preparation method thereof.
Two, background technology
Infantile anorexia is the clinical one group of common digestive functional disturbance disease of department of pediatrics, be to be reduced to cardinal symptom at longer loss of appetite or disappearance, appetite, be common disease among the children's now, can also see sometimes to be mainly in 1-6 year child by card such as hyperhidrosis is arranged, easy to catch cold.Be characterized in that children's there is no tangible organic pathology and changes, tangible anorexia performance is just arranged aspect diet, promptly ingesta is lacked appetite, even a kind of symptom of refusing to eat, like that with voracity food forms significantly contrast.The medicine of treatment infantile anorexia is more, Western medicine such as gastric enzyme mixture, yeast tablet, motilium etc.; Chinese patent medicine such as granule containing ginseng, Siberian cocklebur, lagehead atractylodes, helping digestion of baby Zhibao Dan, health youngster's instant granule for curing etc.But still there is certain drawback in these medicines at aspects such as cure rate, treatment means and medical expenses, still lack the comparatively ideal Chinese medicine preparation of real effectively treatment infantile anorexia at present.
Three, summary of the invention
The Chinese medicine that the purpose of this invention is to provide a kind of eutherapeutic treatment the spleen and stomach in children qi-deficiency type apositia.Technical problem to be solved is to confirm its biological activity after selecting required Chinese herb compound compatibility.
The Chinese medicine of this treatment the spleen and stomach in children qi-deficiency type apositia is characterized in the oral formulations of being made by following parts by weight of Chinese traditional medicine material: Radix Codonopsis 3-15 part, Rhizoma Atractylodis Macrocephalae preparata 1-5 part, Poria 3-15 part, RHIIZOMA DIOSCOREAE frOm Henan of China 3-15 part, Semen Coicis 3-15 part, Fructus Crataegi (parched to brown) 3-9 part, Fructus Hordei Germinatus 3-15 part, CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China 1-5 part, Radix Glycyrrhizae Preparata 1-5 part.
Preferably: Radix Codonopsis 8-10 part, Rhizoma Atractylodis Macrocephalae preparata 2-4 part, Poria 8-10 part, RHIIZOMA DIOSCOREAE frOm Henan of China 8-10 part, Semen Coicis 8-10 part, Fructus Crataegi (parched to brown) 5-7 part, Fructus Hordei Germinatus 8-10 part, CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China 2-4 part, Radix Glycyrrhizae Preparata 2-4 part.
Best: 9 parts of Radix Codonopsis, 3 parts of Rhizoma Atractylodis Macrocephalae preparatas, 9 parts in Poria, 9 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, 9 parts of Semen Coiciss, 6 parts of Fructus Crataegi (parched to brown)s, 9 parts in Fructus Hordei Germinatus, 3 parts of CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China, 3 parts of Radix Glycyrrhizae Preparatas.
Experiment shows, the available adjuvant that pharmaceutically allows processes any oral formulations in the pharmaceutics with known method after above-mentioned herbal mixture material being processed into the former medicine that is rich in active component, as dosage forms such as tablet, capsule, granule, oral liquid, syrups.Preferred particulates agent, oral liquid and syrup.
This preparation method of Chinese medicine comprises the preparation of former medicine and the processing of preparation, and described former medicine preparation is undertaken by following process: measure CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China by proportioning and add 65～75% (mass percentage concentration, down together) alcohol reflux, extracting solution filters, and gets the alcohol extraction filtrate for later use; Measure Radix Codonopsis, Rhizoma Atractylodis Macrocephalae preparata, Poria, RHIIZOMA DIOSCOREAE frOm Henan of China, Semen Coicis, Fructus Crataegi (parched to brown), Fructus Hordei Germinatus, Radix Glycyrrhizae Preparata and CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China medicinal residues by proportioning and decoct with water, decocting liquid filters, filtrate simmer down to clear paste, clear paste is put and is added ethanol after cold and make and contain the alcohol amount and reach 50-60%, stir evenly, leave standstill, filter; Filtrate and above-mentioned alcohol extraction filtrate merge, and reclaim ethanol, are concentrated into thick paste, and thick paste promptly is the former medicine that is rich in active component.
Described preparation processing promptly is that former medicine is prepared into any oral formulations in the pharmaceutics according to a conventional method with the adjuvant that pharmaceutically allows, as make peroral dosage forms such as tablet, capsule, granule, oral liquid, syrup, be preferably granule, oral liquid, syrup.
In described compatibility of drugs:
Radix Codonopsis: sweet, flat.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat disappears and drinks.
Rhizoma Atractylodis Macrocephalae preparata: bitter, sweet, warm.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dry temperature diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Poria: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.
RHIIZOMA DIOSCOREAE frOm Henan of China: hot, warm.Return the stomach warp.The circulation of qi promoting warming middle-JIAO helps digestion, pain relieving.Be used for the chest and diaphragm distension, coldness and pain in the epigastrium, diet does not disappear.
Semen Coicis: sweet, light, cool.Return spleen, stomach, lung meridian.The spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, clearing away heat and discharging pus.Be used for edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, acute appendicitis, verruca plana.
Fructus Crataegi (parched to brown): sour, sweet, tepor.Return spleen, stomach, Liver Channel.Digestion-promoting spleen-invigorating, the circulation of qi promoting dissipating blood stasis.Be used for meat stagnation, gastral cavilty distension, dysentery stomachache, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.It is stagnant to be used to eat meat, and dysentery is not well.
Fructus Hordei Germinatus: sweet, flat.Return spleen, stomach warp.Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite moves back newborn relieving distension.Be used for food stagnation and do not disappear, gastral cavity abdomen stomachache, insufficiency of the spleen lack of appetite, milk smoulders, distending pain of the breast, women's ablactation.
CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China: bitter, hot, warm.Return spleen, stomach, lung, large intestine channel.Expectorant, the therapeutic method to keep the adverse QI flowing downwards are removed full under the dampness.Be used for the humidity hysteresis damaging the spleen and stomach, gastral cavity Pi vomits and diarrhoea, stagnation of QI due to dyspepsia, and abdominal distention constipation, phlegm retention is breathed with cough.
Radix Glycyrrhizae Preparata: sweet, flat.GUIXIN, lung, spleen, stomach warp.Spleen reinforcing stomach function regulating, Yiqi and vein recovery.Be used for weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Medicine of the present invention have the spleen invigorating eliminating dampness by diuresis and in the wake up effect of stomach, cure mainly deficiency of spleen-QI and stomach-QI, lack of appetite is the pool just, the cough of breathing hard, lassitude of the limbs and weakness.
Below further specify the beneficial effect of medicine of the present invention by the pharmacodynamics test of medicine of the present invention.
1, to the fatigue proof influence of mice with spleen deficiency
The large, medium and small dosage group of medicine of the present invention (18g crude drug/kg, 9g crude drug/kg, 4.5g crude drug/kg, be equivalent to 18,9,4.5 times of clinical consumption respectively), by statistics credit analyse and model group relatively, big or middle dosage group swimming time rise appreciably (P＜0.05).Middle dosage group and granule containing ginseng, Siberian cocklebur, lagehead atractylodes group be there was no significant difference (P＞0.05) relatively, illustrates that medicine of the present invention can strengthen the fatigue proof ability of mice.Crude drug promptly is the crude drug Chinese crude drug, down together.
2, to the influence of mice with spleen deficiency hypoxia-bearing capability
The large, medium and small dosage group of medicine of the present invention (18g crude drug/kg, 9g crude drug/kg, 4.5g crude drug/kg, be equivalent to 18,9,4.5 times of clinical consumption respectively), by statistics credit analyse and model group relatively, with model group relatively, each dosage group mice hypoxia endurance time rise appreciably (P＜0.05).Middle dosage group and granule containing ginseng, Siberian cocklebur, lagehead atractylodes group be there was no significant difference (P＞0.05) relatively, illustrates that medicine of the present invention can strengthen the ability of mice anoxia enduring.
3, to the influence of mice with spleen deficiency peritoneal macrophage phagocytic function
The large, medium and small dosage group of medicine of the present invention (18g crude drug/kg, 9g crude drug/kg, 4.5g crude drug/kg, be equivalent to 18,9,4.5 times of clinical consumption respectively), credit is analysed with model group and is compared by statistics, compare with model group, each dosage group Turnover of Mouse Peritoneal Macrophages is engulfed the CRBC percentage rate and is all obviously increased (p＜0.05); Middle dosage group and granule containing ginseng, Siberian cocklebur, lagehead atractylodes group be there was no significant difference (P＞0.05) relatively, illustrates that medicine of the present invention can strengthen the vigor of engulfing of mice with spleen deficiency macrophage.
4, to the influence of mouse small intestine propulsion functions
The large, medium and small dosage group of medicine of the present invention (18g crude drug/kg, 9g crude drug/kg, 4.5g crude drug/kg, be equivalent to 18,9,4.5 times of clinical consumption respectively), credit is analysed by statistics, compares with the normal saline group, and each dosage group mouse small intestine progradation is (P＜0.05) obviously.Middle dosage group and granule containing ginseng, Siberian cocklebur, lagehead atractylodes group be there was no significant difference (P＞0.05) relatively, illustrates that ginseng medicine of the present invention has the function that promotes the mice enterokinesia.
Experiment 1,2,3,4 promptings medicine of the present invention can and promote enterokinesia by health invigorating, improves fuselage state and gastroenteritic power function and reaches facilitating digestion, promotes the effect of appetite.
Four, the specific embodiment
(1) preparation of former medicine
1, gets 9 parts of Radix Codonopsis, 3 parts of Rhizoma Atractylodis Macrocephalae preparatas, 9 parts in Poria, 9 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, 9 parts of Semen Coiciss, 6 parts of Fructus Crataegi (parched to brown)s, 9 parts in Fructus Hordei Germinatus, 3 parts of CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China, 3 parts of Radix Glycyrrhizae Preparatas.
Concrete preparation process is as follows:
Get Cortex Magnoliae Officinalis by proportioning and add 10 times of amount 70% alcohol reflux 3 times, each 1.5 hours, merge extractive liquid,, extracting solution filters, and gets the alcohol extraction filtrate for later use;
Get Radix Codonopsis, Rhizoma Atractylodis Macrocephalae preparata, Poria, RHIIZOMA DIOSCOREAE frOm Henan of China, Semen Coicis, Fructus Crataegi (parched to brown), Fructus Hordei Germinatus, Radix Glycyrrhizae Preparata and CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China medicinal residues by proportioning and add 12 times of water gagings decoctions 2 times, each 2 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.15-1.20 (80 ℃ of heat is surveyed), put cold, adding ethanol makes and contains alcohol amount and reach 50%, stir evenly, left standstill 24 hours, incline and get supernatant, filter, filtrate and above-mentioned Cortex Magnoliae Officinalis alcohol extraction filtrate merge, and reclaim ethanol, and being concentrated into relative density is the thick paste of 1.30-1.35 (80 ℃ of heat are surveyed).Oven dry is ground into fine powder, is prepared into corresponding oral formulations through adding adjuvant.
(2) processing of preparation
2, granule
Get fine drug powder 300g of the present invention and 700g Icing Sugar mixing,, make soft material, cross 40 mesh sieves and granulate, dried 1 hour for 60 ℃ with 80% ethanol moistening, with 40 mesh sieve granulate,, make granule, be distributed into 100 bags.
3, oral liquid
Getting fine drug powder 300g of the present invention, 200g Icing Sugar, 5g sorbic acid adds and is settled to after entry stirs
1000ml transfers pH value to 5.5, and coarse filtration, fine straining are packed in aseptic, clean, exsiccant dactylethrae or the suitable container, seal.Make oral liquid.
4, syrup
Get fine drug powder 300g of the present invention and add water-solubleization, add 600g simple syrup, stone acid antimony potassium 0.1g, ethyl hydroxybenzoate 0.1g,
Add and be settled to 1000ml after entry stirs, in pack into aseptic, clean, exsiccant dactylethrae or the suitable container, sealing.
Make syrup.
5, capsule
Get fine drug powder 150g of the present invention and mix,, make soft material, cross 40 mesh sieves and granulate, dried 1 hour for 60 ℃ with 85% ethanol moistening with 250g starch, encapsulated with 40 mesh sieve granulate, make 1000 of capsules.
6, tablet
Get fine drug powder 150g of the present invention and mix,, make soft material, cross 40 mesh sieves and granulate, dried 1 hour for 60 ℃,, add 5g magnesium stearate, 5g Pulvis Talci mixing, tabletting with 40 mesh sieve granulate with 85% ethanol moistening with the 350g Icing Sugar.Make 1000.
Claims (9)
1. Chinese medicine for the treatment of the spleen and stomach in children qi-deficiency type apositia is characterized in that: the oral formulations of being made by following parts by weight of Chinese traditional medicine material: Radix Codonopsis 3-15 part, Rhizoma Atractylodis Macrocephalae preparata 1-5 part, Poria 3-15 part, RHIIZOMA DIOSCOREAE frOm Henan of China 3-15 part, Semen Coicis 3-15 part, Fructus Crataegi (parched to brown) 3-9 part, Fructus Hordei Germinatus 3-15 part, CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China 1-5 part, Radix Glycyrrhizae Preparata 1-5 part.
2. the Chinese medicine of treatment the spleen and stomach in children qi-deficiency type apositia according to claim 1 is characterized in that being: Radix Codonopsis 8-10 part, Rhizoma Atractylodis Macrocephalae preparata 2-4 part, Poria 8-10 part, RHIIZOMA DIOSCOREAE frOm Henan of China 8-10 part, Semen Coicis 8-10 part, Fructus Crataegi (parched to brown) 5-7 part, Fructus Hordei Germinatus 8-10 part, CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China 2-4 part, Radix Glycyrrhizae Preparata 2-4 part.
3. the Chinese medicine of treatment the spleen and stomach in children qi-deficiency type apositia according to claim 2 is characterized in that: 9 parts of Radix Codonopsis, 3 parts of Rhizoma Atractylodis Macrocephalae preparatas, 9 parts in Poria, 9 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, 9 parts of Semen Coiciss, 6 parts of Fructus Crataegi (parched to brown)s, 9 parts in Fructus Hordei Germinatus, 3 parts of CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China, 3 parts of Radix Glycyrrhizae Preparatas.
4. according to the Chinese medicine of claim 1 or 2 or 3 described treatment the spleen and stomach in children qi-deficiency type apositia, it is characterized in that described preparation is a granule.
5. according to the Chinese medicine of claim 1 or 2 or 3 described treatment the spleen and stomach in children qi-deficiency type apositia, it is characterized in that described preparation is an oral liquid.
6. according to the Chinese medicine of claim 1 or 2 or 3 described treatment the spleen and stomach in children qi-deficiency type apositia, it is characterized in that described preparation is a syrup.
7. according to the Chinese medicine of claim 1 or 2 or 3 described treatment the spleen and stomach in children qi-deficiency type apositia, it is characterized in that described preparation is a capsule.
8. according to the Chinese medicine of claim 1 or 2 or 3 described treatment the spleen and stomach in children qi-deficiency type apositia, it is characterized in that described preparation is a tablet.
9. the preparation method of Chinese medicine of treatment the spleen and stomach in children qi-deficiency type apositia as claimed in claim 1, comprise the preparation of former medicine and the processing of preparation, it is characterized in that: described former medicine preparation is undertaken by following process: measure Cortex Magnoliae Officinalis by proportioning and add 65～75% alcohol reflux, extracting solution filters, and gets the alcohol extraction filtrate for later use; Measure Radix Codonopsis, Rhizoma Atractylodis Macrocephalae preparata, Poria, RHIIZOMA DIOSCOREAE frOm Henan of China, Semen Coicis, Fructus Crataegi (parched to brown), Fructus Hordei Germinatus, Radix Glycyrrhizae Preparata and CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China medicinal residues by proportioning and decoct with water, decocting liquid filters, filtrate simmer down to clear paste, clear paste is put and is added ethanol after cold and make and contain the alcohol amount and reach 50-60%, stir evenly, leave standstill, filter; Filtrate and above-mentioned Cortex Magnoliae Officinalis alcohol extraction filtrate merge, and reclaim ethanol, are concentrated into thick paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102949696A CN101961469B (en) | 2010-09-25 | 2010-09-25 | Traditional Chinese medicine for treating infantile anorexia due to insufficiency of spleen-qi and stomach-qi and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102949696A CN101961469B (en) | 2010-09-25 | 2010-09-25 | Traditional Chinese medicine for treating infantile anorexia due to insufficiency of spleen-qi and stomach-qi and preparation method thereof |
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| CN101961469A CN101961469A (en) | 2011-02-02 |
| CN101961469B true CN101961469B (en) | 2011-09-14 |
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| CN102743655B (en) * | 2012-07-13 | 2013-08-21 | 朱秀平 | Traditional Chinese medicine for treating infantile anorexia |
| CN112891481A (en) * | 2019-12-04 | 2021-06-04 | 易小佳 | Traditional Chinese medicine bag for infant spleen-tonifying stomach-waking bathing |
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| CN1096453A (en) * | 1993-06-15 | 1994-12-21 | 马英丽 | Antidiarrheal digestant for baby |
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