CN105560827B - A kind of ointment and preparation method thereof for perimenopausal syndrome conditioning - Google Patents
A kind of ointment and preparation method thereof for perimenopausal syndrome conditioning Download PDFInfo
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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Abstract
The present invention provides a kind of ointment for perimenopausal syndrome conditioning, are made of the raw material of following weight fraction: 10-20 parts of donkey-hide gelatin, 10-20 parts of colla carapacis et plastri testudinis, 5-10 parts of Chinese yam, 5-10 parts of fructus lycii, 5-10 parts of mulberries, 5-8 parts of pueraria lobata, 5-10 parts of rhizoma polygonati, 3-5 parts of cortex cinnamomi, 5-10 parts of Poria cocos, 8-12 parts of semen ziziphi spinosae, 8-12 parts of rhizoma anemarrhenae, 8-12 parts of Radix Glycyrrhizae, 10-40 parts of walnut kernel, 10-40 parts of Semen sesami nigrum, 10-20 parts of rock sugar, 20-60 parts of yellow rice wine.Ointment provided by the invention can effectively improve the spirit and physiological status of climacteric, and improve hectic fever by the conditionings such as enrich blood, the symptoms such as perspiration, palpitaition, uncomfortable in chest, waist neck are ached, anxiety.
Description
Technical field
The present invention relates to medicines and health protection fields, and in particular to a kind of ointment and its system for perimenopausal syndrome conditioning
Preparation Method.
Background technique
Climacteric refers to one period before and after postmenopausal women, since one's mid-40s in 12 months after menopause when
Phase, including from close to menopause appearance endocrine related with menopause, biology and Clinical symptoms to 1 year after last 1 menstruation,
The namely sign of ovarian failure is continued for after last 1 menstruation 1 year, is normal physiological change period.
But women in climacteric due to ovarian failure, internal decrease in estrogen leads to neuroendocrine
The a series of symptoms that adjustment mechanism is unbalance and occurs, such as hectic fever, perspiration, palpitaition, uncomfortable in chest, waist neck are ached, anxiety, referred to as
" perimenopausal syndrome ".Women rushes conception vessel void through disconnected year, kidney qi degradation, kidney essence deficiency, and body is in a kind of special life
Reason state.Due to the deficiency of the kidney yin, sun loses hiding or decline of kidney-YANG, and passages through which vital energy circulates dystrophy, so as to cause visceral dysfunction, therefore kidney deficiency is
It causes a disease originally.Kidney vital essence virtual loss necessarily involves eight arteries and veins, and kidney water deficiency cannot change gas, and cause blood stasis.
Currently, doctor trained in Western medicine uses hormone replacement therapy, climacteric disease is improved by the Estrogen and progestin of supplemented with exogenous
Shape, but hormone replacement therapy clinical and experimental study in the U.S.'s is shown in recent years, continuous joint increase the events of heart attack, cerebral apoplexy,
Breast cancer and pulmonary embolism etc. are risky.According to theory of traditional Chinese medical science and it facts have proved that long-term food and herbal treatment can significantly change
Symptom that is kind or slowing down perimenopausal syndrome, can make numerous women smoothly spend climacteric.
Chinese patent 201510343876.0 discloses a kind of Chinese materia medica preparation for treating perimenopausal syndrome, specific Chinese medicine
Including cooked aconite (be decocted first) 10g, ling magnet (be decocted first) 30g, calcined Dragon's bone (be decocted first) 30g, Rehmannia glutinosa 10g, Fructus Corni 10g, bosom ox
Knee 10g, Fructus Tritici Levis 10g, Schisandra chinensis 6g, radix glycyrrhizae preparata 6g.Cooked aconite, ling magnet, calcined Dragon's bone warm kidney checking exuberance of yang are monarch, radix rehmanniae preparata in side
Huang, Fructus Corni, Schisandra chinensis receive kidney replenishing essence as minister, and Fructus Tritici Levis, radix glycyrrhizae preparata nourishing heart arrest sweating are assistant, and radix achyranthis bidentatae tying-in is to make.Full side is altogether
Play invigorating heart and kidney, the function of guiding fire to origin.
Chinese patent 201510329489.1 discloses a kind of Chinese medicine composition for treating perimenopausal syndrome, by as follows
The Chinese medicine material of parts by weight is made: thizoma curculiginis 10, Cortex Phellodendri 10, HERBA EPIMEDII 15, Morinda officinalis 15, rhizoma anemarrhenae 12, Radix Rehmanniae 30, the fruit of glossy privet
15, Eclipta prostrata 15, Os Draconis 30, raw oyster 30, mother-of-pearl 30, Radix Angelicae Sinensis 20, have nourshing kidney benefiting yin, and effect of sun is helped in kidney tonifying.
Summary of the invention
It is an advantage of the invention to provide a kind of ointment for perimenopausal syndrome conditioning, which can
Fundamentally improve patient's kidney deficiency, while having effects that nourishing yin and nourishing blood, tonifying spleen nourishing the stomach.
It is another object of the present invention to provide the methods for preparing the ointment.
To achieve the goals above, concrete scheme of the invention is as follows:
A kind of ointment for perimenopausal syndrome conditioning, is made of the raw material of following weight fraction:
10-20 parts of donkey-hide gelatin, 10-20 parts of colla carapacis et plastri testudinis, 5-10 parts of Chinese yam, 5-10 parts of fructus lycii, 5-10 parts of mulberries, Pueraria lobota
5-8 parts of root, 5-10 parts of rhizoma polygonati, 3-5 parts of cortex cinnamomi, 5-10 parts of Poria cocos, 8-12 parts of semen ziziphi spinosae, 8-12 parts of rhizoma anemarrhenae, Radix Glycyrrhizae 8-
12 parts, 10-40 parts of walnut kernel, 10-40 parts of Semen sesami nigrum, 10-20 parts of rock sugar, 20-60 parts of yellow rice wine.
Method the present invention also provides preparation for the ointment of perimenopausal syndrome conditioning, comprising the following steps:
(1) it crushes: weighing the donkey-hide gelatin and colla carapacis et plastri testudinis of the number, co-grinding is spare to 80-100 mesh；
(2) prepared by concentrate: weighing the Chinese yam of the number, pueraria lobata, rhizoma polygonati, cortex cinnamomi, Poria cocos, semen ziziphi spinosae, rhizoma anemarrhenae, sweet
The purified water of 8 times of weight is added in grass, and reflowing 2-2.5 hours, filtrate and filter residue was separately recovered in filtering, will be described in recycling
Filter residue is decocted through multi-reflow, is concentrated under reduced pressure into the relative density at 70-75 DEG C after the filtrate repeatedly obtained is mixed and is
1.10-1.20 obtains concentrate；
(3) change glue: the yellow rice wine that the number is added in infusion container is heated to boiling, and the rock sugar of the number is added,
The donkey-hide gelatin and colla carapacis et plastri testudinis crushed in step (1) is added after dissolving it completely in stirring, and is stirred continuously to it and is completely melt, obtains sugared
Glue；
(4) it refines: by the carbohydrate gum liquid obtained in resulting concentrate addition step (3) of step (2), continuing to stir
It mixes, being concentrated into moisture content is 40%-50%；
(5) mixing: weighing fructus lycii, mulberries, walnut kernel, the Semen sesami nigrum of the number, and is added into dense in step (4)
In contracting liquid, heating stirring is uniformly to get the ointment.
A kind of ointment for perimenopausal syndrome conditioning provided by the invention, according to Chinese medicine monarch, minister, is helped, matching of making
5 mechanism, using donkey-hide gelatin, colla carapacis et plastri testudinis as monarch drug in a prescription, with Chinese yam, fructus lycii, mulberries, pueraria lobata, rhizoma polygonati ministerial drug, with cortex cinnamomi, Poria cocos, wild jujube
Benevolence, rhizoma anemarrhenae are adjutant, are to make medicine with Radix Glycyrrhizae, walnut kernel, Semen sesami nigrum.Wherein donkey-hide gelatin, colla carapacis et plastri testudinis main attack nourishing yin and nourishing blood, Chinese yam, Chinese holly
Matrimony vine, mulberries, pueraria lobata, rhizoma polygonati tonifying spleen nourishing the stomach, it is nourishing liver and kidney, it concentrates and reaches the effect of invigorating the spleen and benefiting qi, and cortex cinnamomi, Poria cocos, wild jujube
The effect of benevolence, rhizoma anemarrhenae mends fire supporing yang, eliminating cold to stop pain, clearing damp and promoting diuresis, enhancing monarch drug in a prescription and ministerial drug, the equal taste of Radix Glycyrrhizae, walnut kernel, Semen sesami nigrum
It is sweet mild-natured, have invigorate the spleen and benefit qi, nourishing liver and kidney effect.
The ointment provided through the invention, it is not only convenient to take,
Meanwhile the method provided by the invention for preparing ointment, the effective component in raw material can not only be made maximumlly to be precipitated,
And it is high for the utilization rate of effective component in raw material, the amalgamation between each ingredient is high, and mutually collaboration can play preferably
Effect, the nutritional ingredient in manufactured colla corii asini cake are equally easy to absorb, will not cause to bear to stomach for physically weak crowd.
The present invention is based on 5 mechanism of interior allotment of Chinese medicine, and that invents on the basis of long-term practice is a suitable for enclosing
The donkey-hide gelatin that menopausal woman is taken for a long time, in good taste, convenient to take, significant effect, advantage without side-effects.
Dosage form: for pill or paste.It or can be in powder, granule, tablet, capsule, cream by reprocessing processing
Any one in agent.
Ointment provided by the invention can effectively improve the spirit and physiological status of climacteric, and pass through the conditioning such as enrich blood
Improve hectic fever, the symptoms such as perspiration, palpitaition, uncomfortable in chest, waist neck are ached, anxiety.Generally, it depending on the situation of user, can take daily
7.5-15 gram/times, 2 times a day.
In addition, this product can be used as food long-term use, taken in flu and intermenstrual period pause.
Specific embodiment
Embodiment 1:
For the donkey-hide gelatin of climacteric conditioning, the raw material including following parts by weight: 10 parts of donkey-hide gelatin, 10 parts of colla carapacis et plastri testudinis,
5 parts of Chinese yam, 5 parts of fructus lycii, 5 parts of mulberries, 5 parts of pueraria lobata, 5 parts of rhizoma polygonati, 3 parts of cortex cinnamomi, 5 parts of Poria cocos, 8 parts of semen ziziphi spinosae, 8 parts of rhizoma anemarrhenae,
8 parts of Radix Glycyrrhizae, 15 parts of walnut, 15 parts of Semen sesami nigrum, 10 parts of rock sugar, 30 parts of yellow rice wine.
The preparation method of donkey-hide gelatin, comprising the following steps:
(1) it crushes: weighing 10 parts of donkey-hide gelatin, 10 parts of colla carapacis et plastri testudinis, be crushed to 80-100 mesh with pulverizer, it is spare.
(2) prepared by concentrate: weigh 5 parts of Chinese yam, 5 parts of pueraria lobata, and 5 parts of rhizoma polygonati, 3 parts of cortex cinnamomi, 5 parts of Poria cocos, 8 parts of semen ziziphi spinosae,
8 parts of rhizoma anemarrhenae, 8 parts of Radix Glycyrrhizae, the purified water of 8 times of weight is added, reflowing 2 hours, filtered to get filtrate a；It is added just in filter residue
The purified water of 3 times of weight of beginning medicinal material, reflowing 2 hours, filtered to get filtrate b；3 times of initial medicinal material amounts are added in filtrate slag
Purified water, reflowing 1 hour, filtered to get filtrate c；Filtrate a, b, c are mixed, are concentrated under reduced pressure, until the phase of mixed liquor
It is 1.10-1.20 (70-75 DEG C) to density, obtains concentrate.
(3) change glue.30 parts of yellow rice wine is added in the container of infusion to be heated to boiling, 10 portions of rock sugar are added, stirring makes it
It dissolves.The donkey-hide gelatin and colla carapacis et plastri testudinis crushed in (1) is added, and is stirred continuously to it and is completely melt, obtains carbohydrate gum liquid.
(4) it refines.Concentrate obtained by step (2) is added to the carbohydrate gum liquid of step (3), continues to stir, is concentrated into moisture and contains
Amount is in 40%-50%.
(5) mixing.5 parts of fructus lycii are weighed, 5 parts of mulberries, 15 parts of walnut, 15 parts of Semen sesami nigrum, is added into step (4)
In concentrate, and heating stirring is uniformly to get donkey-hide gelatin.
Embodiment 2:
For the donkey-hide gelatin of climacteric conditioning, the raw material including following parts by weight: 15 parts of donkey-hide gelatin, 15 parts of colla carapacis et plastri testudinis,
8 parts of Chinese yam, 8 parts of fructus lycii, 8 parts of mulberries, 8 parts of pueraria lobata, 8 parts of rhizoma polygonati, 4 parts of cortex cinnamomi, 6 parts of Poria cocos, 10 parts of semen ziziphi spinosae, rhizoma anemarrhenae 10
Part, 10 parts of Radix Glycyrrhizae, 25 parts of walnut, 25 parts of Semen sesami nigrum, 15 parts of rock sugar, 40 parts of yellow rice wine.
The preparation method of donkey-hide gelatin of the present invention, comprising the following steps:
(1) it crushes: weighing 15 parts of donkey-hide gelatin, 15 parts of colla carapacis et plastri testudinis, be crushed to 80-100 mesh with pulverizer, it is spare.
(2) prepared by concentrate: weigh 8 parts of Chinese yam, 8 parts of pueraria lobata, and 8 parts of rhizoma polygonati, 4 parts of cortex cinnamomi, 6 parts of Poria cocos, 10 parts of semen ziziphi spinosae,
10 parts of rhizoma anemarrhenae, 10 parts of Radix Glycyrrhizae, the purified water of 8 times of weight is added, reflowing 2 hours, filtered to get filtrate a；It is added in filter residue
The purified water of 3 times of weight of initial medicinal material, reflowing 2 hours, filtered to get filtrate b；3 times of initial medicinal material amounts are added in filtrate slag
Purified water, reflowing 1 hour, filtered to get filtrate c；Filtrate a, b, c are mixed, are concentrated under reduced pressure, until mixed liquor
Relative density is 1.10-1.20 (70-75 DEG C), obtains concentrate.
(3) change glue.40 parts of yellow rice wine is added in the container of infusion to be heated to boiling, 15 portions of rock sugar are added, stirring makes it
It dissolves.The donkey-hide gelatin and colla carapacis et plastri testudinis crushed in (1) is added, and is stirred continuously to it and is completely melt, obtains carbohydrate gum liquid.
(4) it refines.Concentrate obtained by step (2) is added to the carbohydrate gum liquid of step (3), continues to stir, is concentrated into moisture and contains
Amount is in 40%-50%.
(5) mixing.8 parts of fructus lycii are weighed, 8 parts of mulberries, 25 parts of walnut, 25 parts of Semen sesami nigrum, is added into step (4)
In concentrate, and heating stirring is uniformly to get donkey-hide gelatin.
Experimental example:
The sample prepared using embodiment 2, in Shanghai City, there are out 60 45-60 years old menstruation irregularis in institute of traditional Chinese medicine
Sweat, hectic fever, vexed, palpitaition, uncomfortable in chest, out of strength, insomnia, failure of memory, waist neck aches, anxiety, osteoporosis, fluctuation of blood pressure etc.
The women of different degrees of symptom, continuously takes 3 months, obtains different degrees of improvement.
Detection method: interrogation is felt the pulse, the Indexs measures such as estradiol, estriol, follicle-stimulating hormone.
As the result is shown: recovery from illness 25 improves 30, and invalid 5, total effective rate 91.6%.
More than, although the description of several embodiments of the invention, but these embodiments are intended only as example proposition
, it is not intended to limit the scope of the present invention.For these new embodiments, can be implemented with various other ways,
In the range of not departing from the gist of the invention, it is able to carry out various omissions, displacement and change.These embodiments and its change
Shape while being contained in scope and spirit of the present invention, is also contained in the invention recorded in claims and its impartial model
In enclosing.
Claims (5)
1. a kind of ointment for perimenopausal syndrome conditioning, which is characterized in that be prepared from the following raw materials in parts by weight:
It is 10-20 parts of donkey-hide gelatin, 10-20 parts of colla carapacis et plastri testudinis, 5-10 parts of Chinese yam, 5-10 parts of fructus lycii, 5-10 parts of mulberries, 5-8 parts of pueraria lobata, yellow
It is 5-10 parts smart, 3-5 parts of cortex cinnamomi, 5-10 parts of Poria cocos, 8-12 parts of semen ziziphi spinosae, 8-12 parts of rhizoma anemarrhenae, 8-12 parts of Radix Glycyrrhizae, walnut kernel 10-40
Part, 10-40 parts of Semen sesami nigrum, 10-20 parts of rock sugar, 20-60 parts of yellow rice wine.
2. a kind of ointment for perimenopausal syndrome conditioning according to claim 1, which is characterized in that by following heavy
The raw material of amount number is made:
12-18 parts of donkey-hide gelatin, 13-17 parts of colla carapacis et plastri testudinis, 6-8 parts of Chinese yam, 6-9 parts of fructus lycii, 7-9 parts of mulberries, 6-8 parts of pueraria lobata, rhizoma polygonati
7-10 parts, 3-4 parts of cortex cinnamomi, 6-8 parts of Poria cocos, 9-11 parts of semen ziziphi spinosae, 9-11 parts of rhizoma anemarrhenae, 9-10 parts of Radix Glycyrrhizae, 20-30 parts of walnut kernel,
20-30 parts of Semen sesami nigrum, 13-17 parts of rock sugar, 30-45 parts of yellow rice wine.
3. a kind of ointment for perimenopausal syndrome conditioning according to claim 1, which is characterized in that by following heavy
The raw material of amount number is made:
15 parts of donkey-hide gelatin, 18 parts of colla carapacis et plastri testudinis, 7 parts of Chinese yam, 8 parts of fructus lycii, 8 parts of mulberries, 7 parts of pueraria lobata, 9 parts of rhizoma polygonati, 4 parts of cortex cinnamomi, Fu
7 parts of Siberian cocklebur, 10 parts of semen ziziphi spinosae, 10 parts of rhizoma anemarrhenae, 10 parts of Radix Glycyrrhizae, 25 parts of walnut kernel, 25 parts of Semen sesami nigrum, 15 parts of rock sugar, 40 parts of yellow rice wine.
4. the preparation method of the ointment according to claim 1-3 for perimenopausal syndrome conditioning, special
Sign is, comprising the following steps:
(1) it crushes: weighing the donkey-hide gelatin and colla carapacis et plastri testudinis of the number, co-grinding is spare to 80-100 mesh；
(2) prepared by concentrate: weighing Chinese yam, pueraria lobata, rhizoma polygonati, cortex cinnamomi, Poria cocos, semen ziziphi spinosae, rhizoma anemarrhenae, the Radix Glycyrrhizae of the number, adds
Enter the purified water of 8 times of weight, reflowing 2-2.5 hours, filtrate and filter residue was separately recovered in filtering, and the filter residue of recycling is passed through
Multi-reflow decocts, and it is 1.10-1.20 that the relative density at 70-75 DEG C is concentrated under reduced pressure into after the filtrate repeatedly obtained is mixed,
Obtain concentrate；
(3) change glue: the yellow rice wine that the number is added in infusion container is heated to boiling, and the rock sugar of the number is added, stirring
The donkey-hide gelatin and colla carapacis et plastri testudinis crushed in step (1) is added after dissolving it completely, and is stirred continuously to it and is completely melt, obtains carbohydrate gum
Liquid；
(4) it refines: by the carbohydrate gum liquid obtained in resulting concentrate addition step (3) of step (2), continuing to stir, it is dense
Being reduced to moisture content is 40%-50%；
(5) mixing: the concentrate for weighing fructus lycii, mulberries, walnut kernel, the Semen sesami nigrum of the number, and being added into step (4)
In, heating stirring is uniformly to get the ointment.
5. the preparation method of the ointment according to claim 4 for perimenopausal syndrome conditioning, which is characterized in that
In step (2), filtrate and filter residue is separately recovered in filtering, and the filter residue of recycling is decocted through multi-reflow, is specifically included:
The filtrate of recycling is initial filtrate, and the medicinal material gross weight for preparing the initial filtrate is added in the filter residue of recycling
The purified water of 3 times of amount, reflowing 2-2.5 hours, filters to obtain second level filtrate, while being equally added again in the filter residue of recycling
The purified water of 3 times of amounts, reflowing 1-1.5 hours, filters to obtain three-level filtrate.
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| CN108378189A (en) * | 2018-01-04 | 2018-08-10 | 白洋 | A kind of colla corii asini candy and preparation method thereof with Chinese herbal ointment formula tanning |
| CN109221994A (en) * | 2018-09-20 | 2019-01-18 | 山东皇菴堂药业有限公司 | A kind of phoenix nest luxuriant growth |
| CN111249394A (en) * | 2020-03-24 | 2020-06-09 | 马毅 | Honey refining paste for treating climacteric syndrome of women and preparation method and application thereof |
| CN114010736B (en) * | 2021-12-24 | 2023-06-02 | 中国人民解放军空军军医大学 | Application of traditional Chinese medicine composition in preparation of medicine for improving anxiety, depression and insomnia caused by non-alcoholic fatty liver |
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