CN1736449A - Powder for climacteric syndrome and its preparing process - Google Patents
Powder for climacteric syndrome and its preparing process Download PDFInfo
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- CN1736449A CN1736449A CN 200510031982 CN200510031982A CN1736449A CN 1736449 A CN1736449 A CN 1736449A CN 200510031982 CN200510031982 CN 200510031982 CN 200510031982 A CN200510031982 A CN 200510031982A CN 1736449 A CN1736449 A CN 1736449A
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- poria
- climacteric
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Abstract
Disclosed is a powder for treating climacteric syndrome and its preparing process, wherein the compositions (by weight ratio) include prepared rehmannia root, tortoise shell, deglued antler powder, epimeddium, Chinese angelica root each 6-9%, rhizoma dioscoreae, motherwort each 10-14%, schisandra fruit, bark of peony root, Chinese mugwort leaf and alisol each 3-7%, poria cocos, amomum fruit each 7-10%, donkey-hide gelatin 1-4%, oryzanol 0.05-0.09%, and vitamin B6 0.01-0.05%.
Description
Technical field:
The present invention relates to a kind of Chinese medicine granules and preparation technology's method thereof, relate in particular to climacteric relaxation grain and preparation method thereof.
Background technology:
Granule is a kind of pharmaceutical dosage form commonly used, according to the relevant laws and regulations of China's drug control, changes dosage form and manages as new drug research.The original dosage form of this product is a tablet, has listed the national drug standards in.
The easypro sheet of existing climacteric is that the medicine composition is the Chinese medicinal tablet of Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Herba Leonuri (four systems), Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis, Poria, Fructus Amomi, Colla Corii Asini, oryzanol, vitamin B6, it is with part pulverizing medicinal materials in the prescription, all the other medicinal material extract, concentrated back add aforementioned medical material fine powder mixing, granulation, drying, tabletting, promptly, the easypro sheet of climacteric is used for the treatment of the caused menoxenia of climacteric obstacle, dizziness, cardiopalmus, insomnia disease.
The onset of the easypro sheet of existing climacteric is fast not as granule.
Summary of the invention:
The purpose of this invention is to provide a kind of can effectively control and ensure drug quality, the treatment onset is faster, be used for the treatment of the caused menoxenia of climacteric obstacle, dizzy, Chinese medicine preparation of cardiopalmus, insomnia disease and preparation method thereof, overcome the above-mentioned drawback of prior art, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
Technical solution of the present invention is a kind of climacteric relaxation grain, it is the caused menoxenia of a kind of treatment climacteric obstacle, dizzy, the Chinese patent medicine of cardiopalmus, insomnia disease, it be the medicine composition be Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis each 7.33%, Rhizoma Dioscoreae, Herba Leonuri (four systems) each 12.21%, Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis each 4.88%, Poria, Fructus Amomi each 8.43%, Colla Corii Asini 2.45%, oryzanol 0.07%, the granule of vitamin B6 0.03%.
The preparation method of climacteric relaxation grain:
(1) get it filled thing constituent and percentage by weight thereof is: Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis each 6～9%, Rhizoma Dioscoreae, Herba Leonuri (four systems) each 10～14%, Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis each 3～7%, Poria, Fructus Amomi each 7～10%, Colla Corii Asini 1～4%, oryzanol 0.05～0.09%, vitamin B6 0.01～0.05%;
(2) in the medicine of (1), get Fructus Amomi, 20% Poria, mix, be ground into the fine powder of 40～200 mesh sieves, sieve, standby;
(3) in the medicine of (1), get Radix Angelicae Sinensis, Cortex Moutan, Fructus Schisandrae Chinensis powder and be broken into coarse powder, according to the percolation under fluid extract and the extractum item (" appendix IO of Chinese pharmacopoeia), make solvent with 70% ethanol, slowly percolation is collected diacolation liquid recycling ethanol to becoming the thick paste shape till the colourless or little yellow of the liquid of filtering;
(4) with eight flavors of residue Poria and all the other Herba Leonuris etc. in (1), decoct with water and extract 1～3 time, add the water of 5～20 times of amounts at every turn, decocted each 1～3 hour; Optimised process adds 10 times of water gagings for the first time and decocted 2 hours for decocting with water 2 times, adds 8 times of water gagings for the second time and decocts 1.5 hours;
(5) decocting liquid that repeatedly decocts gained in (4) is merged, filter;
(6) with the filtrate of (5) gained, add Colla Corii Asini, stir and make dissolving, be evaporated to the thick paste that relative density is 1.1～1.4 (50～60 ℃) below 60 ℃; Best for being concentrated into the thick paste that relative density is 1.2～1.3 (50～60 ℃);
(7) with oryzanol, vitamin B6 mixing in appropriate amount of auxiliary materials and above-mentioned (2) gained fine powder, above-mentioned (1);
(8) thick paste with (6) gained adds in the mixed powder of (7) gained, and mixing is granulated, drying, promptly.
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of climacteric relaxation grain, it is the caused menoxenia of a kind of treatment climacteric obstacle, dizzy, the Chinese patent medicine of cardiopalmus, insomnia disease, it is that the medicine composition is the granule of Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Herba Leonuri (four systems), Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis, Poria, Fructus Amomi, Colla Corii Asini, oryzanol, vitamin B6.
A kind of optimum implementation of climacteric relaxation grain preparation method:
(1) get it filled thing constituent and optimum weight percentage ratio thereof is: Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis each 7.33%, Rhizoma Dioscoreae, Herba Leonuri (four systems) each 12.21%, Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis each 4.88%, Poria, Fructus Amomi each 8.43%, Colla Corii Asini 2.45%, oryzanol 0.07%, vitamin B6 0.03%;
(2) in the above medicine, get Fructus Amomi, 20% Poria, mix, be ground into fine powder; Radix Angelicae Sinensis, Cortex Moutan, Fructus Schisandrae Chinensis powder are broken into coarse powder, according to the percolation under fluid extract and the extractum item (" appendix IO of Chinese pharmacopoeia), make solvent with 70% ethanol, and slowly percolation is till the colourless or little yellow of the liquid of filtering, and diacolation liquid recycling ethanol is to becoming the thick paste shape; Eight flavors such as remaining Poria and all the other Herba Leonuris decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate adds Colla Corii Asini, stirs and makes dissolving, is concentrated into the thick paste shape under 60 ℃; Mixing fine powders, oryzanol, vitamin B6 and the appropriate amount of auxiliary materials mixing of getting Fructus Amomi and Poria are even, and above-mentioned thick paste is added in the mixed powder, and mixing is made granule, promptly.
Advantage of the present invention is: powder for climacteric syndrome can be brought into play rapid-action characteristics behind the drug administration fully, is used for the treatment of The caused irregular menstruation of climacteric obstacle, dizziness, palpitaition, insomnia disease can satisfy the clinical treatment needs better.
Claims (3)
1, a kind of climacteric relaxation grain, it is a kind of climacteric menoxenia of causing of obstacle that is used for the treatment of, dizzy, the Chinese medicine granules of cardiopalmus, insomnia disease, it is characterized in that it be medicine composition and percentage by weight thereof be Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis each 6～9%, Rhizoma Dioscoreae, Herba Leonuri (four systems) each 10～14%, Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis each 3～7%, Poria, Fructus Amomi each 7～10%, Colla Corii Asini 1～4%, oryzanol 0.05～0.09%, vitamin B
60.01～0.05% granule.
2, a kind of preparation method of climacteric relaxation grain is characterized in that:
(1) get it filled thing constituent and percentage by weight thereof is: Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis each 6～9%, Rhizoma Dioscoreae, Herba Leonuri (four systems) each 10～14%, Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis each 3～7%, Poria, Fructus Amomi each 7～10%, Colla Corii Asini 1～4%, oryzanol 0.05～0.09%, vitamin B
60.01～0.05%;
(2) in the medicine of (1), get Fructus Amomi, 20% Poria, mix, be ground into the fine powder of 40～200 mesh sieves, sieve, standby;
(3) in the medicine of (1), get Radix Angelicae Sinensis, Cortex Moutan, Fructus Schisandrae Chinensis powder and be broken into coarse powder, according to the percolation under fluid extract and the extractum item (" Chinese pharmacopoeia appendix I O), make solvent with 70% ethanol, slowly percolation is collected diacolation liquid recycling ethanol to becoming the thick paste shape till the colourless or little yellow of the liquid of filtering;
(4) with eight flavors of residue Poria and all the other Herba Leonuris etc. in (1), decoct with water and extract 1～3 time, add the water of 5～20 times of amounts at every turn, decocted each 1～3 hour; Optimised process adds 10 times of water gagings for the first time and decocted 2 hours for decocting with water 2 times, adds 8 times of water gagings for the second time and decocts 1.5 hours;
(5) decocting liquid that repeatedly decocts gained in (4) is merged, filter;
(6) with the filtrate of (5) gained, add Colla Corii Asini, stir and make dissolving, be evaporated to the thick paste that relative density is 1.1～1.4 (50～60 ℃) below 60 ℃; Best for being concentrated into the thick paste that relative density is 1.2～1.3 (50～60 ℃);
(7) with oryzanol, vitamin B in appropriate amount of auxiliary materials and above-mentioned (2) gained fine powder, above-mentioned (1)
6Mixing;
(8) thick paste with (6) gained adds in the mixed powder of (7) gained, and mixing is granulated, drying, promptly.
3, climacteric relaxation grain according to claim 1, the optimum weight percentage ratio that it is characterized in that its medicine constituent be Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis each 7.33%, Rhizoma Dioscoreae, Herba Leonuri (four systems) each 12.21%, Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis each 4.88%, Poria, Fructus Amomi each 8.43%, Colla Corii Asini 2.45%, oryzanol 0.07%, vitamin B
60.03%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510031982 CN1736449A (en) | 2005-08-08 | 2005-08-08 | Powder for climacteric syndrome and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510031982 CN1736449A (en) | 2005-08-08 | 2005-08-08 | Powder for climacteric syndrome and its preparing process |
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| CN1736449A true CN1736449A (en) | 2006-02-22 |
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| CN 200510031982 Pending CN1736449A (en) | 2005-08-08 | 2005-08-08 | Powder for climacteric syndrome and its preparing process |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884640A (en) * | 2010-07-01 | 2010-11-17 | 北京世纪博康医药科技有限公司 | Application of oryzanol |
| CN102847075A (en) * | 2012-09-27 | 2013-01-02 | 郭秀翠 | Medicine composition for treating insomnia |
| CN105560827A (en) * | 2015-12-25 | 2016-05-11 | 东阿阿胶股份有限公司 | Ointment for conditioning perimenopausal syndromes and preparation method thereof |
| CN105769879A (en) * | 2016-03-15 | 2016-07-20 | 山东仁和堂药业有限公司 | Medicinal preparation for calming and helping sleep and preparation method thereof |
-
2005
- 2005-08-08 CN CN 200510031982 patent/CN1736449A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884640A (en) * | 2010-07-01 | 2010-11-17 | 北京世纪博康医药科技有限公司 | Application of oryzanol |
| CN101884640B (en) * | 2010-07-01 | 2012-04-18 | 北京世纪博康医药科技有限公司 | Application of oryzanol |
| CN102847075A (en) * | 2012-09-27 | 2013-01-02 | 郭秀翠 | Medicine composition for treating insomnia |
| CN105560827A (en) * | 2015-12-25 | 2016-05-11 | 东阿阿胶股份有限公司 | Ointment for conditioning perimenopausal syndromes and preparation method thereof |
| CN105560827B (en) * | 2015-12-25 | 2019-03-15 | 东阿阿胶股份有限公司 | A kind of ointment and preparation method thereof for perimenopausal syndrome conditioning |
| CN105769879A (en) * | 2016-03-15 | 2016-07-20 | 山东仁和堂药业有限公司 | Medicinal preparation for calming and helping sleep and preparation method thereof |
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Effective date of registration: 20060310 Address after: Xinqiao village, Mawangdui Township, Changsha City, Hunan Applicant after: Shi Yu Address before: No. seven, 20 Mile Road, Chenzhou, Hunan, Chenzhou, Hunan, China Applicant before: Huang Kaiqi |
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